ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.86150976
2	nuclear pore organization (GO:0006999)	6.19086540
3	DNA replication checkpoint (GO:0000076)	5.40725873
4	regulation of translational fidelity (GO:0006450)	5.22791575
5	pore complex assembly (GO:0046931)	5.19053978
6	protoporphyrinogen IX metabolic process (GO:0046501)	4.76820371
7	gas transport (GO:0015669)	4.74290497
8	regulation of histone H3-K4 methylation (GO:0051569)	4.71742795
9	oxygen transport (GO:0015671)	4.67147215
10	diterpenoid biosynthetic process (GO:0016102)	4.64294139
11	DNA unwinding involved in DNA replication (GO:0006268)	4.63990248
12	DNA topological change (GO:0006265)	4.53411622
13	terpenoid biosynthetic process (GO:0016114)	4.48802581
14	regulation of histone H3-K27 methylation (GO:0061085)	4.46332415
15	mitotic sister chromatid segregation (GO:0000070)	4.41728240
16	DNA replication initiation (GO:0006270)	4.34280678
17	sister chromatid segregation (GO:0000819)	4.32830019
18	mitotic nuclear envelope disassembly (GO:0007077)	4.32105205
19	synapsis (GO:0007129)	4.31544069
20	tRNA aminoacylation for protein translation (GO:0006418)	4.15790924
21	formation of translation preinitiation complex (GO:0001731)	4.10589770
22	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.02592354
23	tRNA aminoacylation (GO:0043039)	3.99786626
24	amino acid activation (GO:0043038)	3.99786626
25	membrane disassembly (GO:0030397)	3.99776110
26	nuclear envelope disassembly (GO:0051081)	3.99776110
27	erythrocyte maturation (GO:0043249)	3.99736794
28	oxidative phosphorylation (GO:0006119)	3.99092873
29	resolution of meiotic recombination intermediates (GO:0000712)	3.98738534
30	DNA strand elongation involved in DNA replication (GO:0006271)	3.97355088
31	vitamin A metabolic process (GO:0006776)	3.96240636
32	DNA strand elongation (GO:0022616)	3.87593133
33	folic acid-containing compound biosynthetic process (GO:0009396)	3.86748410
34	regulation of RNA export from nucleus (GO:0046831)	3.85611992
35	purine nucleobase biosynthetic process (GO:0009113)	3.74508468
36	isoprenoid biosynthetic process (GO:0008299)	3.68001486
37	microtubule depolymerization (GO:0007019)	3.60953821
38	meiotic chromosome segregation (GO:0045132)	3.60494891
39	regulation of translational elongation (GO:0006448)	3.54241397
40	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.50699126
41	telomere maintenance via semi-conservative replication (GO:0032201)	3.46787448
42	intra-S DNA damage checkpoint (GO:0031573)	3.44858242
43	positive regulation of histone H3-K4 methylation (GO:0051571)	3.44718475
44	IMP biosynthetic process (GO:0006188)	3.37634961
45	homocysteine metabolic process (GO:0050667)	3.37626485
46	nucleobase biosynthetic process (GO:0046112)	3.27702713
47	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.26985340
48	oxaloacetate metabolic process (GO:0006107)	3.25837431
49	proline biosynthetic process (GO:0006561)	3.25293088
50	proteasome assembly (GO:0043248)	3.24834201
51	definitive hemopoiesis (GO:0060216)	3.24591837
52	tetrahydrofolate metabolic process (GO:0046653)	3.19336528
53	mitotic recombination (GO:0006312)	3.16441760
54	chromosome segregation (GO:0007059)	3.13970610
55	succinate metabolic process (GO:0006105)	3.13072827
56	COPI coating of Golgi vesicle (GO:0048205)	3.12887446
57	Golgi transport vesicle coating (GO:0048200)	3.12887446
58	telomere maintenance via recombination (GO:0000722)	3.11418156
59	regulation of histone methylation (GO:0031060)	3.11211871
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.11077223
61	creatine metabolic process (GO:0006600)	3.10605474
62	IMP metabolic process (GO:0046040)	3.08447638
63	regulation of mitotic spindle organization (GO:0060236)	3.05747115
64	DNA methylation involved in gamete generation (GO:0043046)	3.04031672
65	protein localization to kinetochore (GO:0034501)	3.03256668
66	mismatch repair (GO:0006298)	2.98517887
67	mitotic chromosome condensation (GO:0007076)	2.96015817
68	protein export from nucleus (GO:0006611)	2.95758830
69	negative regulation of erythrocyte differentiation (GO:0045647)	2.92549760
70	regulation of nucleobase-containing compound transport (GO:0032239)	2.88257002
71	response to vitamin A (GO:0033189)	2.86111006
72	nuclear envelope organization (GO:0006998)	2.85485449
73	kinetochore organization (GO:0051383)	2.83404305
74	ribosomal large subunit biogenesis (GO:0042273)	2.81883200
75	ATP synthesis coupled proton transport (GO:0015986)	2.81076857
76	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.81076857
77	protein-cofactor linkage (GO:0018065)	2.72124894
78	protein localization to chromosome, centromeric region (GO:0071459)	2.70778111
79	DNA catabolic process, exonucleolytic (GO:0000738)	2.69774264
80	negative regulation of chromosome segregation (GO:0051985)	2.69751006
81	mitotic spindle checkpoint (GO:0071174)	2.69515101
82	positive regulation of histone methylation (GO:0031062)	2.69392232
83	mRNA transport (GO:0051028)	2.69154317
84	regulation of centriole replication (GO:0046599)	2.67361734
85	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.67225925
86	negative regulation of sister chromatid segregation (GO:0033046)	2.67225925
87	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.67225925
88	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.67225925
89	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.67225925
90	iron ion import (GO:0097286)	2.66853494
91	sensory perception of smell (GO:0007608)	2.66793589
92	regulation of chromosome segregation (GO:0051983)	2.65548171
93	mitotic spindle assembly checkpoint (GO:0007094)	2.65062069
94	erythrocyte development (GO:0048821)	2.64757514
95	spindle assembly checkpoint (GO:0071173)	2.62598604
96	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.61516458
97	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.61516458
98	viral mRNA export from host cell nucleus (GO:0046784)	2.60253429
99	microtubule polymerization or depolymerization (GO:0031109)	2.59878124
100	granulocyte differentiation (GO:0030851)	2.58684435

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.02843942
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.84684432
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.82837856
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.39976082
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.13794344
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09048932
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.08163681
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.06833755
9	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.91862954
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.74790822
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.72279510
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72016721
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.70622004
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.54707172
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.42317009
16	NCOR1_26117541_ChIP-Seq_K562_Human	2.37908839
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.34749977
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.32011033
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.30475975
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28217421
21	GATA1_19941826_ChIP-Seq_K562_Human	2.26783310
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.23736026
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21202223
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.16648149
25	VDR_23849224_ChIP-Seq_CD4+_Human	2.15362877
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.15054686
27	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.13751026
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.07911653
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.99320175
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98191068
31	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.96802168
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.95390292
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.95051740
34	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.94952047
35	GATA1_22025678_ChIP-Seq_K562_Human	1.91575606
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.90624779
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.90360899
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.85280448
39	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.84050282
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.83627409
41	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.80318263
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.73502591
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70369338
44	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.70099490
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66452193
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.66142145
47	CIITA_25753668_ChIP-Seq_RAJI_Human	1.65268683
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.64674458
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57337865
50	GATA2_19941826_ChIP-Seq_K562_Human	1.54269625
51	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.52654586
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.45145666
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43832841
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40638363
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40166220
56	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37213730
57	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34172041
58	VDR_22108803_ChIP-Seq_LS180_Human	1.31996480
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30083310
60	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.29733894
61	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.29321350
62	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29043624
63	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.28962539
64	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.28878614
65	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.24553989
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.22953209
67	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.22200210
68	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21098927
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19269836
70	AR_21909140_ChIP-Seq_LNCAP_Human	1.18104509
71	SPI1_23127762_ChIP-Seq_K562_Human	1.12465860
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.11641332
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07752151
74	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.05171085
75	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04012267
76	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.03417310
77	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.00126049
78	TFEB_21752829_ChIP-Seq_HELA_Human	0.98951781
79	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96693951
80	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.95433858
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94953449
82	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92755842
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.91767955
84	PHF8_20622853_ChIP-Seq_HELA_Human	0.90885884
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.90541013
86	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.86614759
87	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.86240168
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85810555
89	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85097448
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.83915879
91	SCL_19346495_ChIP-Seq_HPC-7_Human	0.83313778
92	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.82390630
93	MYC_22102868_ChIP-Seq_BL_Human	0.81202270
94	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.80740154
95	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.79211635
96	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.76778500
97	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.75684327
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.75616849
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.75327077
100	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.75111194

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.24881717
2	MP0008058_abnormal_DNA_repair	4.15542824
3	MP0008995_early_reproductive_senescence	4.13848123
4	MP0004957_abnormal_blastocyst_morpholog	4.04566856
5	MP0010094_abnormal_chromosome_stability	3.86156099
6	MP0003693_abnormal_embryo_hatching	3.60435588
7	MP0003111_abnormal_nucleus_morphology	3.55927178
8	MP0003656_abnormal_erythrocyte_physiolo	3.31951912
9	MP0009697_abnormal_copulation	3.10578121
10	MP0008057_abnormal_DNA_replication	3.06425179
11	MP0003786_premature_aging	2.74839545
12	MP0008932_abnormal_embryonic_tissue	2.72699092
13	MP0003077_abnormal_cell_cycle	2.40408365
14	MP0000678_abnormal_parathyroid_gland	2.36616822
15	MP0005451_abnormal_body_composition	2.30894468
16	MP0000372_irregular_coat_pigmentation	2.26047842
17	MP0008007_abnormal_cellular_replicative	2.22944369
18	MP0004145_abnormal_muscle_electrophysio	2.16103684
19	MP0006036_abnormal_mitochondrial_physio	2.09708905
20	MP0003718_maternal_effect	2.04725512
21	MP0006035_abnormal_mitochondrial_morpho	2.01700159
22	MP0005083_abnormal_biliary_tract	1.92197623
23	MP0003221_abnormal_cardiomyocyte_apopto	1.70299279
24	MP0001730_embryonic_growth_arrest	1.54290384
25	MP0002132_abnormal_respiratory_system	1.53390702
26	MP0000350_abnormal_cell_proliferation	1.50775058
27	MP0005397_hematopoietic_system_phenotyp	1.47155514
28	MP0001545_abnormal_hematopoietic_system	1.47155514
29	MP0004233_abnormal_muscle_weight	1.46914825
30	MP0002009_preneoplasia	1.45050767
31	MP0001697_abnormal_embryo_size	1.44939224
32	MP0003186_abnormal_redox_activity	1.44728561
33	MP0001929_abnormal_gametogenesis	1.39867222
34	MP0000313_abnormal_cell_death	1.39784765
35	MP0010307_abnormal_tumor_latency	1.36190577
36	MP0001529_abnormal_vocalization	1.33302649
37	MP0002396_abnormal_hematopoietic_system	1.31917501
38	MP0002080_prenatal_lethality	1.29590397
39	MP0002210_abnormal_sex_determination	1.27490917
40	MP0005636_abnormal_mineral_homeostasis	1.25242653
41	MP0000703_abnormal_thymus_morphology	1.22842273
42	MP0001661_extended_life_span	1.20075912
43	MP0001727_abnormal_embryo_implantation	1.19187935
44	MP0001672_abnormal_embryogenesis/_devel	1.18039619
45	MP0005380_embryogenesis_phenotype	1.18039619
46	MP0003959_abnormal_lean_body	1.15380950
47	MP0003806_abnormal_nucleotide_metabolis	1.14511253
48	MP0005408_hypopigmentation	1.11294138
49	MP0003984_embryonic_growth_retardation	1.07040248
50	MP0002019_abnormal_tumor_incidence	1.06856865
51	MP0002139_abnormal_hepatobiliary_system	1.06706931
52	MP0008775_abnormal_heart_ventricle	1.03392242
53	MP0002086_abnormal_extraembryonic_tissu	1.02830859
54	MP0002088_abnormal_embryonic_growth/wei	1.01860628
55	MP0002722_abnormal_immune_system	1.01432734
56	MP0006276_abnormal_autonomic_nervous	1.01167251
57	MP0003698_abnormal_male_reproductive	0.98308547
58	MP0000647_abnormal_sebaceous_gland	0.97385852
59	MP0001764_abnormal_homeostasis	0.96721548
60	MP0003567_abnormal_fetal_cardiomyocyte	0.93727303
61	MP0002269_muscular_atrophy	0.93521699
62	MP0002398_abnormal_bone_marrow	0.93470116
63	MP0000358_abnormal_cell_content/	0.92630948
64	MP0000653_abnormal_sex_gland	0.92459649
65	MP0001145_abnormal_male_reproductive	0.91719610
66	MP0006292_abnormal_olfactory_placode	0.89737710
67	MP0009278_abnormal_bone_marrow	0.86839095
68	MP0000689_abnormal_spleen_morphology	0.86766399
69	MP0004134_abnormal_chest_morphology	0.84929031
70	MP0005645_abnormal_hypothalamus_physiol	0.82300471
71	MP0005410_abnormal_fertilization	0.81904988
72	MP0002084_abnormal_developmental_patter	0.80637074
73	MP0005171_absent_coat_pigmentation	0.80510787
74	MP0000609_abnormal_liver_physiology	0.80186337
75	MP0004197_abnormal_fetal_growth/weight/	0.80113346
76	MP0003646_muscle_fatigue	0.79381685
77	MP0001502_abnormal_circadian_rhythm	0.77944490
78	MP0003699_abnormal_female_reproductive	0.76984465
79	MP0001873_stomach_inflammation	0.76026356
80	MP0002877_abnormal_melanocyte_morpholog	0.75964162
81	MP0004084_abnormal_cardiac_muscle	0.75748960
82	MP0002161_abnormal_fertility/fecundity	0.74132844
83	MP0002085_abnormal_embryonic_tissue	0.72830685
84	MP0008770_decreased_survivor_rate	0.72430613
85	MP0008877_abnormal_DNA_methylation	0.71918084
86	MP0003890_abnormal_embryonic-extraembry	0.70958952
87	MP0004043_abnormal_pH_regulation	0.70756445
88	MP0002095_abnormal_skin_pigmentation	0.69769165
89	MP0002429_abnormal_blood_cell	0.67043257
90	MP0005332_abnormal_amino_acid	0.66606574
91	MP0001119_abnormal_female_reproductive	0.64544666
92	MP0009703_decreased_birth_body	0.64488246
93	MP0005187_abnormal_penis_morphology	0.62712952
94	MP0005535_abnormal_body_temperature	0.62296959
95	MP0004808_abnormal_hematopoietic_stem	0.62287397
96	MP0002970_abnormal_white_adipose	0.62118677
97	MP0009333_abnormal_splenocyte_physiolog	0.61998727
98	MP0005266_abnormal_metabolism	0.60958169
99	MP0003385_abnormal_body_wall	0.60440042
100	MP0000598_abnormal_liver_morphology	0.59796440

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	7.11953612
2	Cholecystitis (HP:0001082)	7.11953612
3	Truncus arteriosus (HP:0001660)	5.88722188
4	Reticulocytosis (HP:0001923)	5.09221923
5	Ankyloglossia (HP:0010296)	4.26723611
6	Abnormal hemoglobin (HP:0011902)	4.22705064
7	Abnormality of reticulocytes (HP:0004312)	4.20760907
8	Polycythemia (HP:0001901)	4.19349865
9	Hyperthyroidism (HP:0000836)	4.17179768
10	Abnormality of glycolysis (HP:0004366)	3.96237807
11	Cortical dysplasia (HP:0002539)	3.87897322
12	Increased serum pyruvate (HP:0003542)	3.82461965
13	Homocystinuria (HP:0002156)	3.80925301
14	Abnormality of homocysteine metabolism (HP:0010919)	3.80925301
15	Upper limb muscle weakness (HP:0003484)	3.77522779
16	Birth length less than 3rd percentile (HP:0003561)	3.76495132
17	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.69542545
18	Bowel incontinence (HP:0002607)	3.67719491
19	Cholelithiasis (HP:0001081)	3.63078188
20	Abnormal large intestine physiology (HP:0012700)	3.50157459
21	Chromsome breakage (HP:0040012)	3.35561814
22	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.32347751
23	Seborrheic dermatitis (HP:0001051)	3.31549538
24	Abnormal gallbladder morphology (HP:0012437)	3.30464622
25	Hypertensive crisis (HP:0100735)	3.25178427
26	Abnormality of oral frenula (HP:0000190)	3.15839953
27	Peripheral hypomyelination (HP:0007182)	3.05762441
28	Ileus (HP:0002595)	3.02984090
29	Poikilocytosis (HP:0004447)	2.94489049
30	Abnormality of cochlea (HP:0000375)	2.85847866
31	Acute myeloid leukemia (HP:0004808)	2.81803840
32	Nonimmune hydrops fetalis (HP:0001790)	2.80533286
33	Hyperbilirubinemia (HP:0002904)	2.75105314
34	Orthostatic hypotension (HP:0001278)	2.69410866
35	Hypoparathyroidism (HP:0000829)	2.68561597
36	Pallor (HP:0000980)	2.59523456
37	Abnormality of the gallbladder (HP:0005264)	2.54244702
38	Atelectasis (HP:0100750)	2.49571101
39	Abnormality of the tricuspid valve (HP:0001702)	2.44963394
40	Duplicated collecting system (HP:0000081)	2.43424702
41	Tinnitus (HP:0000360)	2.41848200
42	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.35058233
43	Reticulocytopenia (HP:0001896)	2.34009873
44	Myelodysplasia (HP:0002863)	2.30502196
45	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.28588247
46	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.27554288
47	Morphological abnormality of the inner ear (HP:0011390)	2.25442166
48	Combined immunodeficiency (HP:0005387)	2.22121709
49	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.16179662
50	Abnormality of the renal collecting system (HP:0004742)	2.11177258
51	Aplastic anemia (HP:0001915)	2.11100479
52	Increased nuchal translucency (HP:0010880)	2.07115323
53	Flat cornea (HP:0007720)	2.03851609
54	Severe combined immunodeficiency (HP:0004430)	2.01515278
55	Acanthocytosis (HP:0001927)	2.00222312
56	Small intestinal stenosis (HP:0012848)	1.95591456
57	Duodenal stenosis (HP:0100867)	1.95591456
58	Abnormally folded helix (HP:0008544)	1.95225138
59	Abnormality of DNA repair (HP:0003254)	1.92106837
60	Sandal gap (HP:0001852)	1.91509431
61	Abnormality of the labia minora (HP:0012880)	1.87953142
62	Granulocytopenia (HP:0001913)	1.85902328
63	Obsessive-compulsive behavior (HP:0000722)	1.82266799
64	Overlapping toe (HP:0001845)	1.80724132
65	Delayed myelination (HP:0012448)	1.79528167
66	Adenoma sebaceum (HP:0009720)	1.79500755
67	Angiofibromas (HP:0010615)	1.79500755
68	Autoamputation (HP:0001218)	1.78697459
69	Abnormality of the preputium (HP:0100587)	1.76362438
70	Limb hypertonia (HP:0002509)	1.75416014
71	Abnormal lung lobation (HP:0002101)	1.75062339
72	Progressive external ophthalmoplegia (HP:0000590)	1.72579713
73	Increased serum lactate (HP:0002151)	1.72542502
74	Cortical visual impairment (HP:0100704)	1.71813506
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71291839
76	Abnormality of the pons (HP:0007361)	1.71055493
77	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69835930
78	Acute encephalopathy (HP:0006846)	1.68806212
79	Abnormal number of erythroid precursors (HP:0012131)	1.67328219
80	Palpitations (HP:0001962)	1.65710219
81	Attention deficit hyperactivity disorder (HP:0007018)	1.64489021
82	Insomnia (HP:0100785)	1.61744870
83	Cheekbone underdevelopment (HP:0010669)	1.61464801
84	Abnormality of the anterior horn cell (HP:0006802)	1.60747662
85	Degeneration of anterior horn cells (HP:0002398)	1.60747662
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.59518187
87	Acute necrotizing encephalopathy (HP:0006965)	1.57789241
88	Abnormality of chromosome stability (HP:0003220)	1.57765112
89	Pancytopenia (HP:0001876)	1.57493949
90	Increased hepatocellular lipid droplets (HP:0006565)	1.57450103
91	Premature ovarian failure (HP:0008209)	1.57265494
92	Termporal pattern (HP:0011008)	1.54723303
93	Insidious onset (HP:0003587)	1.54723303
94	Horseshoe kidney (HP:0000085)	1.54005335
95	Fatigue (HP:0012378)	1.53904449
96	Neuroendocrine neoplasm (HP:0100634)	1.53110573
97	Macrocytic anemia (HP:0001972)	1.53091328
98	Pheochromocytoma (HP:0002666)	1.52953543
99	Delusions (HP:0000746)	1.52701453
100	Dysmetric saccades (HP:0000641)	1.52324692

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK4	4.40773518
2	EIF2AK1	4.39310150
3	TTK	3.41321744
4	KSR2	3.29356632
5	BMPR2	3.06062204
6	CLK1	3.01593473
7	SRPK1	2.67218931
8	CDC7	2.66321857
9	BRSK2	2.61182147
10	BUB1	2.45919635
11	RAF1	2.44344556
12	NTRK3	2.41392729
13	CCNB1	2.40076351
14	TSSK6	2.19544184
15	MAP3K2	2.18432458
16	PLK4	2.13294392
17	WEE1	2.13043490
18	KSR1	2.12833592
19	EEF2K	2.02229092
20	NEK1	1.82134385
21	EIF2AK3	1.74199470
22	MAP3K4	1.61217546
23	NME1	1.53104602
24	PBK	1.46416635
25	SCYL2	1.37612641
26	MST4	1.34633617
27	BRSK1	1.28631623
28	BMX	1.23216934
29	ATR	1.20433927
30	EPHA3	1.20393768
31	WNK4	1.19268641
32	PLK3	1.16227565
33	PDK2	1.15772758
34	NEK2	1.15264519
35	BCR	1.10300713
36	MAP3K8	1.09071314
37	CHEK2	1.01864449
38	TRPM7	0.99354939
39	PASK	0.91847283
40	CHEK1	0.87122191
41	TEC	0.83915681
42	TAOK3	0.83012524
43	MATK	0.82756289
44	JAK2	0.81637323
45	TRIM28	0.81141232
46	RPS6KB2	0.76732600
47	ATM	0.76323781
48	PIK3CG	0.75714766
49	PLK1	0.73958218
50	TNIK	0.73700701
51	MAP4K2	0.72700674
52	RPS6KA4	0.72463491
53	MAPKAPK3	0.72315537
54	JAK3	0.69559129
55	MKNK1	0.69546113
56	PINK1	0.69108069
57	CDK1	0.68245085
58	ALK	0.63885552
59	PIM1	0.62788837
60	BTK	0.62646736
61	CDK2	0.62371926
62	MAP2K1	0.62307564
63	MAPKAPK5	0.62246248
64	STK4	0.61959239
65	WNK1	0.57901574
66	AURKB	0.56320442
67	PAK1	0.54969918
68	STK3	0.53598256
69	PLK2	0.52790733
70	CSNK2A2	0.52439237
71	MARK3	0.52314236
72	DYRK3	0.52245031
73	SIK3	0.51599411
74	YES1	0.49116532
75	MAP3K6	0.48516911
76	ERBB3	0.48452934
77	RET	0.46476589
78	NTRK1	0.46314207
79	ZAK	0.45325375
80	CSNK1E	0.43789860
81	CSNK2A1	0.43727962
82	MAP3K1	0.42367055
83	RPS6KA5	0.41702448
84	EPHB1	0.41510817
85	TESK2	0.39184879
86	EIF2AK2	0.36141738
87	ICK	0.36075738
88	STK10	0.35651922
89	BRD4	0.33964914
90	BLK	0.33580419
91	PTK6	0.33398786
92	CDK12	0.32968784
93	PRKAA1	0.29593306
94	STK16	0.25330708
95	SYK	0.25092501
96	AKT2	0.24077083
97	GSK3B	0.22895003
98	CDK7	0.21945653
99	ITK	0.21652092
100	ERBB2	0.21445040

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.65117544
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.08817212
3	DNA replication_Homo sapiens_hsa03030	3.41656312
4	Mismatch repair_Homo sapiens_hsa03430	3.38352276
5	One carbon pool by folate_Homo sapiens_hsa00670	3.19402153
6	Homologous recombination_Homo sapiens_hsa03440	2.68684472
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.59318300
8	RNA transport_Homo sapiens_hsa03013	2.51308143
9	Spliceosome_Homo sapiens_hsa03040	2.46619737
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.36200971
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.16206964
12	Basal transcription factors_Homo sapiens_hsa03022	2.06935813
13	Cell cycle_Homo sapiens_hsa04110	2.05492685
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.04880029
15	Proteasome_Homo sapiens_hsa03050	2.01416235
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00604197
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95366416
18	Pyruvate metabolism_Homo sapiens_hsa00620	1.89797307
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.84418580
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.74242424
21	mRNA surveillance pathway_Homo sapiens_hsa03015	1.62280754
22	Ribosome_Homo sapiens_hsa03010	1.60925902
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.59503618
24	Protein export_Homo sapiens_hsa03060	1.56309705
25	Carbon metabolism_Homo sapiens_hsa01200	1.54891835
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.54497973
27	RNA degradation_Homo sapiens_hsa03018	1.48360427
28	Base excision repair_Homo sapiens_hsa03410	1.41988246
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41252357
30	RNA polymerase_Homo sapiens_hsa03020	1.38757084
31	Parkinsons disease_Homo sapiens_hsa05012	1.36261351
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.30872594
33	Olfactory transduction_Homo sapiens_hsa04740	1.21593568
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.20706599
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.20231360
36	Propanoate metabolism_Homo sapiens_hsa00640	1.18347647
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13532690
38	Acute myeloid leukemia_Homo sapiens_hsa05221	1.11121067
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10422727
40	Oocyte meiosis_Homo sapiens_hsa04114	1.09479576
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.05205212
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.03759621
43	Huntingtons disease_Homo sapiens_hsa05016	1.02012423
44	Butanoate metabolism_Homo sapiens_hsa00650	1.00284628
45	Thyroid cancer_Homo sapiens_hsa05216	0.98037002
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.94188230
47	Type II diabetes mellitus_Homo sapiens_hsa04930	0.93461015
48	Purine metabolism_Homo sapiens_hsa00230	0.92707451
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90203029
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82069646
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81187343
52	mTOR signaling pathway_Homo sapiens_hsa04150	0.77994838
53	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.77753364
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75624943
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74943031
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72104530
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.71955759
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67761871
59	Alzheimers disease_Homo sapiens_hsa05010	0.65293141
60	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.62723007
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.59114705
62	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.57377705
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.56764465
64	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55260969
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55027306
66	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.53517785
67	Metabolic pathways_Homo sapiens_hsa01100	0.43112340
68	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.42599305
69	Fatty acid elongation_Homo sapiens_hsa00062	0.42515575
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41967443
71	Pancreatic cancer_Homo sapiens_hsa05212	0.41709284
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.41515146
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.39298686
74	ErbB signaling pathway_Homo sapiens_hsa04012	0.39043932
75	Hepatitis B_Homo sapiens_hsa05161	0.38247376
76	Measles_Homo sapiens_hsa05162	0.36749283
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36255657
78	Insulin signaling pathway_Homo sapiens_hsa04910	0.36128538
79	Shigellosis_Homo sapiens_hsa05131	0.34630092
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.32888092
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31598646
82	Renal cell carcinoma_Homo sapiens_hsa05211	0.31335323
83	Glutathione metabolism_Homo sapiens_hsa00480	0.30495257
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.28450154
85	Nicotine addiction_Homo sapiens_hsa05033	0.27997819
86	Non-small cell lung cancer_Homo sapiens_hsa05223	0.27692397
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26671870
88	p53 signaling pathway_Homo sapiens_hsa04115	0.25201287
89	Colorectal cancer_Homo sapiens_hsa05210	0.24189400
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23421694
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.19029737
92	Herpes simplex infection_Homo sapiens_hsa05168	0.16278841
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15401327
94	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.14400784
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.10861695
96	Prion diseases_Homo sapiens_hsa05020	0.10393905
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.06924685
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.06455497
99	Taste transduction_Homo sapiens_hsa04742	0.06139275
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.05899763

SOD1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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