SOD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)5.20135446
2lysine metabolic process (GO:0006553)5.20135446
3drug transmembrane transport (GO:0006855)4.84122585
4urate metabolic process (GO:0046415)4.81718798
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.51310908
6cell migration involved in heart development (GO:0060973)4.42621390
7valine metabolic process (GO:0006573)4.22036638
8epoxygenase P450 pathway (GO:0019373)4.21299065
9protein heterotrimerization (GO:0070208)4.09374689
10barbed-end actin filament capping (GO:0051016)4.07442261
11homocysteine metabolic process (GO:0050667)4.04446604
12drug transport (GO:0015893)4.03242020
13fatty acid beta-oxidation (GO:0006635)4.01994212
14glyoxylate metabolic process (GO:0046487)3.98181497
15aminoglycoside antibiotic metabolic process (GO:0030647)3.96974568
16cysteine metabolic process (GO:0006534)3.95497602
17quaternary ammonium group transport (GO:0015697)3.89686620
18organic cation transport (GO:0015695)3.87461570
19tricarboxylic acid metabolic process (GO:0072350)3.86275919
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82029071
21virion attachment to host cell (GO:0019062)3.81464718
22adhesion of symbiont to host cell (GO:0044650)3.81464718
23vascular endothelial growth factor signaling pathway (GO:0038084)3.81152922
24branched-chain amino acid metabolic process (GO:0009081)3.76873582
25response to mercury ion (GO:0046689)3.76122911
26low-density lipoprotein particle clearance (GO:0034383)3.74390393
27fatty acid oxidation (GO:0019395)3.69304616
28lipid oxidation (GO:0034440)3.62867956
29short-chain fatty acid metabolic process (GO:0046459)3.62558597
30phosphate ion transport (GO:0006817)3.59981897
312-oxoglutarate metabolic process (GO:0006103)3.55709708
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53614554
33L-phenylalanine metabolic process (GO:0006558)3.53614554
34adhesion of symbiont to host (GO:0044406)3.49712428
35positive regulation of endothelial cell apoptotic process (GO:2000353)3.48874708
36cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.48516110
37collagen fibril organization (GO:0030199)3.47444180
38L-phenylalanine catabolic process (GO:0006559)3.43065677
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43065677
40biotin metabolic process (GO:0006768)3.42971910
41negative regulation of smooth muscle cell migration (GO:0014912)3.42838273
42amino-acid betaine transport (GO:0015838)3.41172738
43carnitine transport (GO:0015879)3.41172738
44retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39580723
45fatty acid catabolic process (GO:0009062)3.38897236
46aspartate family amino acid catabolic process (GO:0009068)3.38561911
47triglyceride catabolic process (GO:0019433)3.38117364
48ovulation from ovarian follicle (GO:0001542)3.34671139
49amino-acid betaine metabolic process (GO:0006577)3.32994323
50drug catabolic process (GO:0042737)3.32791776
51branched-chain amino acid catabolic process (GO:0009083)3.32383516
52blood vessel maturation (GO:0001955)3.30900960
53metanephric tubule development (GO:0072170)3.30626341
54metanephric nephron tubule development (GO:0072234)3.30626341
55acetyl-CoA metabolic process (GO:0006084)3.27889116
56alpha-linolenic acid metabolic process (GO:0036109)3.27118236
57endocrine hormone secretion (GO:0060986)3.25868528
58exogenous drug catabolic process (GO:0042738)3.24608725
59carnitine metabolic process (GO:0009437)3.24396423
60sulfur amino acid catabolic process (GO:0000098)3.23352871
61phosphate ion transmembrane transport (GO:0035435)3.22600688
62keratan sulfate catabolic process (GO:0042340)3.21214291
63aromatic amino acid family catabolic process (GO:0009074)3.15224059
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14125849
65atrioventricular valve morphogenesis (GO:0003181)3.12109181
66metanephric nephron epithelium development (GO:0072243)3.10870376
67bone trabecula formation (GO:0060346)3.06959494
68neutral lipid catabolic process (GO:0046461)3.05893121
69acylglycerol catabolic process (GO:0046464)3.05893121
70cellular modified amino acid catabolic process (GO:0042219)3.05616565
71endocardial cushion development (GO:0003197)3.03588944
72positive regulation of receptor recycling (GO:0001921)3.03347225
73positive regulation of fatty acid oxidation (GO:0046321)3.03315300
74opsonization (GO:0008228)3.02940223
75metanephric mesenchyme development (GO:0072075)3.01371362
76toxin metabolic process (GO:0009404)3.01349182
77monocarboxylic acid catabolic process (GO:0072329)3.01010416
78negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.00510347
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.96947563
80glomerular filtration (GO:0003094)2.96920251
81stress fiber assembly (GO:0043149)2.95814931
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.94490760
83regulation of integrin-mediated signaling pathway (GO:2001044)2.94115514
84apoptotic cell clearance (GO:0043277)2.94075523
85regulation of extracellular matrix disassembly (GO:0010715)2.94025962
86surfactant homeostasis (GO:0043129)2.93458822
87type B pancreatic cell proliferation (GO:0044342)2.90786398
88negative regulation of cartilage development (GO:0061037)2.89685314
89NADH metabolic process (GO:0006734)2.88047066
90cellular response to vitamin (GO:0071295)2.87966334
91indole-containing compound catabolic process (GO:0042436)2.86809347
92indolalkylamine catabolic process (GO:0046218)2.86809347
93tryptophan catabolic process (GO:0006569)2.86809347
94cell proliferation involved in metanephros development (GO:0072203)2.86755201
95renal filtration (GO:0097205)2.86309826
96fatty acid transmembrane transport (GO:1902001)2.84268219
97drug metabolic process (GO:0017144)2.83917931
98response to phenylpropanoid (GO:0080184)2.83575149
99endothelial cell chemotaxis (GO:0035767)2.83156123
100dermatan sulfate metabolic process (GO:0030205)2.82944946
101metanephric epithelium development (GO:0072207)2.82356881
102regulation of sequestering of triglyceride (GO:0010889)2.81822158
103peptidyl-glutamic acid carboxylation (GO:0017187)2.79958107
104protein carboxylation (GO:0018214)2.79958107
105extracellular fibril organization (GO:0043206)2.79043047
106response to growth hormone (GO:0060416)2.78700702
107kidney mesenchyme development (GO:0072074)2.78515198
108renal absorption (GO:0070293)2.77393208
109serine family amino acid catabolic process (GO:0009071)2.77338712
110regulation of cholesterol homeostasis (GO:2000188)2.76002333
111planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74533761
112cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74206299
113regulation of plasminogen activation (GO:0010755)2.72649782
114regulation of fatty acid oxidation (GO:0046320)2.71133265
115endodermal cell differentiation (GO:0035987)2.70572306
116cellular ketone body metabolic process (GO:0046950)2.69961770
117NADP metabolic process (GO:0006739)2.69826973
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.69551942
119axon extension involved in axon guidance (GO:0048846)2.69551942
120tryptophan metabolic process (GO:0006568)2.68900459
121oxaloacetate metabolic process (GO:0006107)2.68263801
122protein localization to cell surface (GO:0034394)2.67215090
123excretion (GO:0007588)2.66172669
124skin morphogenesis (GO:0043589)2.65985932
125peptide catabolic process (GO:0043171)2.64912632
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64706495
127dermatan sulfate biosynthetic process (GO:0030208)2.64611314
128carnitine transmembrane transport (GO:1902603)2.64433785
129regulation of fatty acid beta-oxidation (GO:0031998)2.63884141
130carnitine shuttle (GO:0006853)2.62605756
131adherens junction assembly (GO:0034333)2.62432001
132sulfur compound catabolic process (GO:0044273)2.61882368
133sequestering of extracellular ligand from receptor (GO:0035581)2.61779530
134collagen metabolic process (GO:0032963)2.61277833
135response to lead ion (GO:0010288)2.60138752
136embryo implantation (GO:0007566)2.59892259
137carboxylic acid catabolic process (GO:0046395)2.59605439
138organic acid catabolic process (GO:0016054)2.59605439
139cell-substrate junction assembly (GO:0007044)2.59186701
140kynurenine metabolic process (GO:0070189)2.58541193
141ethanol oxidation (GO:0006069)2.57938208
142extracellular matrix assembly (GO:0085029)2.57934344
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.57786540
144fibril organization (GO:0097435)2.57529514
145endothelial cell morphogenesis (GO:0001886)2.57492117
146basement membrane organization (GO:0071711)2.56720609
147extracellular matrix organization (GO:0030198)2.56328498
148vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55563532
149extracellular structure organization (GO:0043062)2.55270425
150tooth mineralization (GO:0034505)2.55014921
151growth hormone secretion (GO:0030252)2.53947030
152glycosaminoglycan catabolic process (GO:0006027)2.51297854
153glomerular basement membrane development (GO:0032836)2.50803418
154desmosome organization (GO:0002934)2.50544581
155positive regulation of pseudopodium assembly (GO:0031274)2.48778515
156extracellular matrix disassembly (GO:0022617)2.48310979
157cell proliferation involved in kidney development (GO:0072111)2.47991270
158multicellular organismal macromolecule metabolic process (GO:0044259)2.47519224
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46583729
160negative regulation of chondrocyte differentiation (GO:0032331)2.46351906
161epithelial cell-cell adhesion (GO:0090136)2.45965849
162smooth muscle tissue development (GO:0048745)2.45913689
163protein retention in ER lumen (GO:0006621)2.44044571
164collagen catabolic process (GO:0030574)2.43882918
165UV protection (GO:0009650)2.43545084
166regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40498545
167multicellular organismal metabolic process (GO:0044236)2.39691148
168transcytosis (GO:0045056)2.38054892
169chondroitin sulfate catabolic process (GO:0030207)2.35945468
170cellular response to nutrient (GO:0031670)2.35622989
171cell-substrate adherens junction assembly (GO:0007045)2.34736954
172focal adhesion assembly (GO:0048041)2.34736954
173chondrocyte proliferation (GO:0035988)2.31801395
174cGMP-mediated signaling (GO:0019934)2.31604476
175negative regulation of fatty acid transport (GO:2000192)2.31538464
176regulation of smooth muscle cell migration (GO:0014910)2.29735918
177negative regulation of smooth muscle cell proliferation (GO:0048662)2.28951733
178negative regulation of homotypic cell-cell adhesion (GO:0034111)2.28434051
179cAMP biosynthetic process (GO:0006171)2.27958390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.67735819
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.94960030
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.82817895
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.93251804
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.90495517
6CLOCK_20551151_ChIP-Seq_293T_Human3.81922597
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.29683879
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.28614182
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.17314272
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.16226475
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.10389668
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.62013257
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30880153
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14834085
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.14354939
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11034966
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.10742616
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05406533
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00186507
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94453178
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76107668
22CJUN_26792858_Chip-Seq_BT549_Human1.67712749
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67660315
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.58176017
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54848093
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50189851
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46178016
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46047900
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.44750868
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.43156995
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.43156995
32KDM2B_26808549_Chip-Seq_K562_Human1.43033724
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40770607
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40703243
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40636836
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39550796
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39550796
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35410800
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34867234
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.33121449
41LXR_22292898_ChIP-Seq_THP-1_Human1.32507142
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31753107
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31363319
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29087131
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.28376535
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26600429
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26017077
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.23704876
49* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21973448
50GATA1_22025678_ChIP-Seq_K562_Human1.21289481
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21072792
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21007585
53CTCF_27219007_Chip-Seq_Bcells_Human1.20154251
54SA1_22415368_ChIP-Seq_MEFs_Mouse1.18721575
55RACK7_27058665_Chip-Seq_MCF-7_Human1.18441932
56SOX2_20726797_ChIP-Seq_SW620_Human1.17910604
57KDM2B_26808549_Chip-Seq_DND41_Human1.17349095
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.14512934
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14502945
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13469150
61* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10691671
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09706396
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09636161
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.09490907
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08824468
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07936240
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07694603
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07072009
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.06801017
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05970681
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.04605154
72SMC4_20622854_ChIP-Seq_HELA_Human1.04560694
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04477337
74TP53_23651856_ChIP-Seq_MEFs_Mouse1.04439423
75* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04216914
76* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04079379
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03738295
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03649166
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.03260628
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02933710
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02894771
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02701100
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02637364
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02621822
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.01378055
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00200256
87* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98830913
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98566316
89P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98214530
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.97521858
91SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96763220
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95914695
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95368892
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95368892
95SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94189377
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93563079
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.93510685
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93483617
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.91455728
100DROSHA_22980978_ChIP-Seq_HELA_Human0.91259937
101* EZH2_27294783_Chip-Seq_ESCs_Mouse0.91136098
102TP53_22127205_ChIP-Seq_IMR90_Human0.91026633
103STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90856057
104* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90685151
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90214207
106MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90109101
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89697832
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88527018
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87853261
110ZNF263_19887448_ChIP-Seq_K562_Human0.87538128
111* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87517267
112SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86342253
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85251107
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84419245
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84152601
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.83167355
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83010982
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82976756
119* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82592024
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81515680
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81361356
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80933487
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80316296
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79815163
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76706660
126ATF3_27146783_Chip-Seq_COLON_Human0.76632364
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76014346
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75907920
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75883563
130TP53_20018659_ChIP-ChIP_R1E_Mouse0.75455041
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75279304
132GATA4_25053715_ChIP-Seq_YYC3_Human0.73607755
133RXR_22108803_ChIP-Seq_LS180_Human0.71959950
134HNF4A_19822575_ChIP-Seq_HepG2_Human0.71370083
135BRD4_25478319_ChIP-Seq_HGPS_Human0.70245764
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69979718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.64314963
2MP0001958_emphysema4.59996917
3MP0005275_abnormal_skin_tensile4.51363948
4MP0003705_abnormal_hypodermis_morpholog4.25932503
5MP0005360_urolithiasis4.05838836
6MP0005503_abnormal_tendon_morphology3.83256551
7MP0003279_aneurysm3.35358686
8MP0002139_abnormal_hepatobiliary_system3.12546824
9MP0009384_cardiac_valve_regurgitation2.92233857
10MP0005332_abnormal_amino_acid2.47548553
11MP0002254_reproductive_system_inflammat2.36855914
12MP0005670_abnormal_white_adipose2.31215480
13MP0002138_abnormal_hepatobiliary_system2.17875212
14MP0004272_abnormal_basement_membrane2.06633420
15MP0010368_abnormal_lymphatic_system1.96533640
16MP0004019_abnormal_vitamin_homeostasis1.95885295
17MP0002295_abnormal_pulmonary_circulatio1.91981677
18MP0008875_abnormal_xenobiotic_pharmacok1.89995334
19MP0003195_calcinosis1.88597073
20MP0009643_abnormal_urine_homeostasis1.84427434
21MP0005365_abnormal_bile_salt1.81142132
22MP0003252_abnormal_bile_duct1.72975228
23MP0004043_abnormal_pH_regulation1.69636091
24MP0005666_abnormal_adipose_tissue1.68859213
25MP0003191_abnormal_cellular_cholesterol1.67926356
26MP0001756_abnormal_urination1.63547347
27MP0001879_abnormal_lymphatic_vessel1.53711512
28MP0010329_abnormal_lipoprotein_level1.47031782
29MP0010234_abnormal_vibrissa_follicle1.46469782
30MP0009780_abnormal_chondrocyte_physiolo1.45414613
31MP0002108_abnormal_muscle_morphology1.43583159
32MP0006054_spinal_hemorrhage1.42104743
33MP0002060_abnormal_skin_morphology1.40644484
34MP0001765_abnormal_ion_homeostasis1.39093015
35MP0004130_abnormal_muscle_cell1.37505420
36MP0004858_abnormal_nervous_system1.36795639
37MP0005085_abnormal_gallbladder_physiolo1.34460780
38MP0005375_adipose_tissue_phenotype1.33803647
39MP0003566_abnormal_cell_adhesion1.31691861
40MP0000751_myopathy1.31628663
41MP0002136_abnormal_kidney_physiology1.30681862
42MP0003186_abnormal_redox_activity1.27757956
43MP0000013_abnormal_adipose_tissue1.27607717
44MP0010030_abnormal_orbit_morphology1.24780420
45MP0002168_other_aberrant_phenotype1.23299101
46MP0005508_abnormal_skeleton_morphology1.16720065
47MP0005636_abnormal_mineral_homeostasis1.16672005
48MP0005058_abnormal_lysosome_morphology1.13186618
49MP0002837_dystrophic_cardiac_calcinosis1.10689688
50MP0002118_abnormal_lipid_homeostasis1.09262935
51MP0005584_abnormal_enzyme/coenzyme_acti1.08385807
52MP0001542_abnormal_bone_strength1.07645380
53MP0005319_abnormal_enzyme/_coenzyme1.06984457
54MP0004185_abnormal_adipocyte_glucose1.05691640
55MP0005595_abnormal_vascular_smooth1.04327005
56MP0003329_amyloid_beta_deposits1.02355034
57MP0005409_darkened_coat_color1.02151470
58MP0005023_abnormal_wound_healing1.01152694
59MP0000003_abnormal_adipose_tissue1.00658539
60MP0000343_altered_response_to0.99375021
61MP0002971_abnormal_brown_adipose0.99320030
62MP0003011_delayed_dark_adaptation0.98496512
63MP0002876_abnormal_thyroid_physiology0.97697643
64MP0002896_abnormal_bone_mineralization0.97487881
65MP0005623_abnormal_meninges_morphology0.95356720
66MP0001849_ear_inflammation0.94662837
67MP0000681_abnormal_thyroid_gland0.94253236
68MP0003300_gastrointestinal_ulcer0.94165234
69MP0000230_abnormal_systemic_arterial0.93526010
70MP0001348_abnormal_lacrimal_gland0.91244777
71MP0003828_pulmonary_edema0.90837286
72MP0000759_abnormal_skeletal_muscle0.90403200
73MP0005388_respiratory_system_phenotype0.89194314
74MP0002133_abnormal_respiratory_system0.89194314
75MP0003950_abnormal_plasma_membrane0.89184545
76MP0002249_abnormal_larynx_morphology0.89051264
77MP0002998_abnormal_bone_remodeling0.88037614
78MP0000767_abnormal_smooth_muscle0.86672641
79MP0009115_abnormal_fat_cell0.86228192
80MP0000609_abnormal_liver_physiology0.85821776
81MP0002970_abnormal_white_adipose0.85796743
82MP0004087_abnormal_muscle_fiber0.85374203
83MP0008775_abnormal_heart_ventricle0.83177751
84MP0005165_increased_susceptibility_to0.81873439
85MP0000538_abnormal_urinary_bladder0.81631741
86MP0004883_abnormal_blood_vessel0.81271938
87MP0001299_abnormal_eye_distance/0.80206314
88MP0009840_abnormal_foam_cell0.79016458
89MP0003806_abnormal_nucleotide_metabolis0.78592114
90MP0000163_abnormal_cartilage_morphology0.78288364
91MP0001661_extended_life_span0.77600079
92MP0003045_fibrosis0.77340273
93MP0006138_congestive_heart_failure0.75944278
94MP0008961_abnormal_basal_metabolism0.75198974
95MP0002972_abnormal_cardiac_muscle0.74667323
96MP0000750_abnormal_muscle_regeneration0.74426661
97MP0009764_decreased_sensitivity_to0.74420852
98MP0005164_abnormal_response_to0.74373942
99MP0002115_abnormal_skeleton_extremities0.74236726
100MP0002877_abnormal_melanocyte_morpholog0.74169040
101MP0004036_abnormal_muscle_relaxation0.74002614
102MP0001177_atelectasis0.73862614
103MP0005369_muscle_phenotype0.72976962
104MP0001614_abnormal_blood_vessel0.72915697
105MP0000249_abnormal_blood_vessel0.72861614
106MP0000749_muscle_degeneration0.72646630
107MP0005084_abnormal_gallbladder_morpholo0.71838609
108MP0003091_abnormal_cell_migration0.71660344
109MP0000762_abnormal_tongue_morphology0.70918027
110MP0002135_abnormal_kidney_morphology0.70819876
111MP0004782_abnormal_surfactant_physiolog0.69799225
112MP0002796_impaired_skin_barrier0.69311950
113MP0001243_abnormal_dermal_layer0.68270815
114MP0005330_cardiomyopathy0.68140355
115MP0002113_abnormal_skeleton_development0.67606871
116MP0005257_abnormal_intraocular_pressure0.67419809
117MP0000858_altered_metastatic_potential0.67258708
118* MP0005390_skeleton_phenotype0.66758506
119MP0000604_amyloidosis0.66253104
120MP0005377_hearing/vestibular/ear_phenot0.66219877
121MP0003878_abnormal_ear_physiology0.66219877
122MP0001881_abnormal_mammary_gland0.64627032
123MP0003795_abnormal_bone_structure0.64365055
124MP0003448_altered_tumor_morphology0.64230697
125MP0004084_abnormal_cardiac_muscle0.64212227
126MP0005167_abnormal_blood-brain_barrier0.64139679
127MP0000747_muscle_weakness0.63063389
128MP0001544_abnormal_cardiovascular_syste0.62750188
129MP0005385_cardiovascular_system_phenoty0.62750188
130MP0003646_muscle_fatigue0.62746992
131MP0003115_abnormal_respiratory_system0.62188104
132MP0000534_abnormal_ureter_morphology0.62050794
133MP0005501_abnormal_skin_physiology0.62029917
134* MP0001533_abnormal_skeleton_physiology0.61675349
135MP0002128_abnormal_blood_circulation0.61428987
136MP0005535_abnormal_body_temperature0.61413833
137MP0005620_abnormal_muscle_contractility0.60265711
138MP0003959_abnormal_lean_body0.58650346
139* MP0002933_joint_inflammation0.57980653

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.24341822
2Premature rupture of membranes (HP:0001788)5.30517905
3Hyperglycinuria (HP:0003108)4.00879956
4Gout (HP:0001997)3.90303666
5Aortic aneurysm (HP:0004942)3.89523607
6Increased circulating renin level (HP:0000848)3.87983604
7Hyperactive renin-angiotensin system (HP:0000841)3.77896271
8Hypokalemic alkalosis (HP:0001949)3.75485831
9Soft skin (HP:0000977)3.56792442
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.53399120
11Broad metatarsal (HP:0001783)3.42332546
12Metabolic alkalosis (HP:0200114)3.41181862
13Abnormality of serine family amino acid metabolism (HP:0010894)3.35314354
14Abnormality of glycine metabolism (HP:0010895)3.35314354
15Aortic dissection (HP:0002647)3.28587723
16Bladder diverticulum (HP:0000015)3.18313566
17Abnormality of skeletal muscle fiber size (HP:0012084)3.17638981
18Abnormal urine output (HP:0012590)3.16272488
19Peritonitis (HP:0002586)3.15724557
20Abnormality of chloride homeostasis (HP:0011422)3.15601812
21Abnormality of complement system (HP:0005339)3.14630678
22Renal salt wasting (HP:0000127)3.09466332
23Polyuria (HP:0000103)3.09124862
24Vascular tortuosity (HP:0004948)3.06821461
25Systemic lupus erythematosus (HP:0002725)3.06330366
26Oligomenorrhea (HP:0000876)3.05390608
27Ketoacidosis (HP:0001993)3.04402453
28Proximal tubulopathy (HP:0000114)3.04249010
29Hypomagnesemia (HP:0002917)3.03910088
30Increased purine levels (HP:0004368)2.98038364
31Hyperuricemia (HP:0002149)2.98038364
32Hydroxyprolinuria (HP:0003080)2.98004905
33Abnormality of proline metabolism (HP:0010907)2.98004905
34Abnormality of purine metabolism (HP:0004352)2.97088575
35Abnormality of renal excretion (HP:0011036)2.94954772
36Ankle contracture (HP:0006466)2.92789401
37Ketosis (HP:0001946)2.89489020
38Pulmonary artery stenosis (HP:0004415)2.85945112
39Cardiovascular calcification (HP:0011915)2.85676523
40Abnormality of fatty-acid metabolism (HP:0004359)2.85076877
41Acanthosis nigricans (HP:0000956)2.84918759
42Mildly elevated creatine phosphokinase (HP:0008180)2.82489398
43Dilatation of the ascending aorta (HP:0005111)2.78385577
44Arterial tortuosity (HP:0005116)2.76836459
45Vertebral compression fractures (HP:0002953)2.75664604
46Slender build (HP:0001533)2.75577464
47Cerebral aneurysm (HP:0004944)2.70925552
48Distal lower limb muscle weakness (HP:0009053)2.69625748
49Increased connective tissue (HP:0009025)2.67194148
50Abnormality of renin-angiotensin system (HP:0000847)2.64016765
51Hyperaldosteronism (HP:0000859)2.63726213
52Xanthomatosis (HP:0000991)2.62486905
53Generalized aminoaciduria (HP:0002909)2.60309526
54Overgrowth (HP:0001548)2.56550037
55Joint laxity (HP:0001388)2.55067145
56Abnormality of magnesium homeostasis (HP:0004921)2.54279653
57Aortic valve stenosis (HP:0001650)2.53514815
58Neonatal short-limb short stature (HP:0008921)2.52156768
59Asymmetric septal hypertrophy (HP:0001670)2.50904939
60Shallow orbits (HP:0000586)2.50552263
61Atrophic scars (HP:0001075)2.49703600
62Obstructive sleep apnea (HP:0002870)2.48369287
63Wrist flexion contracture (HP:0001239)2.48235972
64Aortic regurgitation (HP:0001659)2.45103278
65Mitral regurgitation (HP:0001653)2.44498768
66Emphysema (HP:0002097)2.43094468
67Mitral stenosis (HP:0001718)2.41620329
68Follicular hyperkeratosis (HP:0007502)2.41065233
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.40061180
70Osteolytic defects of the hand bones (HP:0009699)2.40061180
71Alkalosis (HP:0001948)2.39041777
72Spinal rigidity (HP:0003306)2.37341014
73Blue sclerae (HP:0000592)2.36930830
74Thin bony cortex (HP:0002753)2.34104775
75Polydipsia (HP:0001959)2.31645230
76Abnormal drinking behavior (HP:0030082)2.31645230
77Hyperammonemia (HP:0001987)2.30527565
78Biconcave vertebral bodies (HP:0004586)2.28184707
79Wormian bones (HP:0002645)2.27163075
80Tetany (HP:0001281)2.25129396
81Fragile skin (HP:0001030)2.24461185
82Coronal craniosynostosis (HP:0004440)2.23607447
83Type 1 muscle fiber predominance (HP:0003803)2.23441306
84Hyperglycinemia (HP:0002154)2.23223259
85Dysostosis multiplex (HP:0000943)2.22179014
86Ectopia lentis (HP:0001083)2.20868426
87Cervical subluxation (HP:0003308)2.19944263
88Vascular calcification (HP:0004934)2.19708743
89Aneurysm (HP:0002617)2.18331594
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14888074
91Dicarboxylic aciduria (HP:0003215)2.14888074
92Urinary glycosaminoglycan excretion (HP:0003541)2.14691951
93Mucopolysacchariduria (HP:0008155)2.14691951
94Ovoid vertebral bodies (HP:0003300)2.14627648
95Deep venous thrombosis (HP:0002625)2.12937216
96Spondylolisthesis (HP:0003302)2.12892066
97Mitral valve prolapse (HP:0001634)2.10825854
98Bronchomalacia (HP:0002780)2.10671963
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08820583
100Abnormality of polysaccharide metabolism (HP:0011012)2.08820583
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08820583
102Nephrolithiasis (HP:0000787)2.07919946
103Polycythemia (HP:0001901)2.07693289
104Chondrocalcinosis (HP:0000934)2.04138336
105Hypokalemia (HP:0002900)2.03179983
106Hypoglycemic coma (HP:0001325)2.02905124
107Hypertriglyceridemia (HP:0002155)2.02426540
108Joint stiffness (HP:0001387)2.02236504
109Delayed CNS myelination (HP:0002188)2.00176453
110Lymphangioma (HP:0100764)1.99685281
111Abnormality of nucleobase metabolism (HP:0010932)1.98598715
112Abnormality of the acetabulum (HP:0003170)1.97926965
113Elbow flexion contracture (HP:0002987)1.97759038
114Persistence of primary teeth (HP:0006335)1.97270395
115Right ventricular cardiomyopathy (HP:0011663)1.96782164
116Rectal prolapse (HP:0002035)1.96298192
117Short nail (HP:0001799)1.95182550
118Muscle fiber splitting (HP:0003555)1.94814079
119Generalized amyotrophy (HP:0003700)1.92359611
120Hyperextensible skin (HP:0000974)1.92346452
121Abnormal delivery (HP:0001787)1.92001001
122Renal tubular acidosis (HP:0001947)1.91581768
123Complement deficiency (HP:0004431)1.90555467
124Nuclear cataract (HP:0100018)1.90112128
125Hypoventilation (HP:0002791)1.90018368
126Round ear (HP:0100830)1.89503015
127Wide anterior fontanel (HP:0000260)1.89239988
128Increased variability in muscle fiber diameter (HP:0003557)1.89223639
129Infantile muscular hypotonia (HP:0008947)1.88282335
130Coxa vara (HP:0002812)1.87956634
131Abnormality of Sharpey fibers (HP:0100685)1.87682368
132Turricephaly (HP:0000262)1.86837693
133Distal lower limb amyotrophy (HP:0008944)1.86811679
134Bowel diverticulosis (HP:0005222)1.86462906
135Genu recurvatum (HP:0002816)1.86323256
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86012207
137Hypercalciuria (HP:0002150)1.85507067
138Abnormality of dentin (HP:0010299)1.85431249
139Natal tooth (HP:0000695)1.83660715
140Achilles tendon contracture (HP:0001771)1.82778256
141Abnormality of potassium homeostasis (HP:0011042)1.82059653
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81311692
143Advanced eruption of teeth (HP:0006288)1.81040535
144Ulnar deviation of the wrist (HP:0003049)1.80026050
145Bone cyst (HP:0012062)1.79958502
146Bradycardia (HP:0001662)1.79250237
147Osteoarthritis (HP:0002758)1.78758965
148Abnormal cartilage morphology (HP:0002763)1.77791237
149Hypoplasia of the iris (HP:0007676)1.77733395
150Sparse lateral eyebrow (HP:0005338)1.77415985
151Hand muscle atrophy (HP:0009130)1.77115459
152Beaking of vertebral bodies (HP:0004568)1.76872002
153Skin nodule (HP:0200036)1.76747477
154Long toe (HP:0010511)1.76287709
155Striae distensae (HP:0001065)1.75401503
156Venous abnormality (HP:0002624)1.75238639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.39109977
2TRIB34.18029859
3WNK43.94241445
4BCKDK3.87629094
5WNK33.43604108
6TESK13.41376602
7TIE12.88579580
8OXSR12.83156200
9EPHA22.70598033
10TGFBR22.69008949
11PDK32.26820113
12PDK42.26820113
13LATS22.24443933
14FGFR42.13442237
15PDGFRA2.12848990
16DDR22.01018322
17SIK12.00897324
18MAP3K61.87727271
19CDC42BPA1.81457980
20TTN1.81214845
21EPHB11.77996523
22GRK51.74658661
23STK38L1.72382858
24PDK21.70377129
25EPHB21.69188692
26FER1.67579413
27CAMK1D1.57847639
28RIPK11.56508667
29MYLK1.55725582
30LIMK11.52464960
31MST1R1.45031247
32STK391.41805316
33PKN21.37355394
34EPHA31.30261428
35PTK2B1.28753832
36MAPK151.22463195
37NEK91.15472065
38MAP3K31.14092831
39CAMK1G1.14023584
40LRRK21.08872955
41MET1.06925481
42PTK21.06129127
43PTK61.04664728
44MAPK71.03880346
45GRK10.98729475
46PAK40.96427991
47RPS6KA20.95205377
48LMTK20.94387797
49PRPF4B0.93917590
50PAK30.91239973
51LATS10.91136752
52ICK0.89752499
53ARAF0.87542602
54EEF2K0.85516988
55MAP2K10.84674354
56WNK10.84518578
57PRKAA20.81561499
58MARK20.81163910
59ADRBK10.81162281
60ZAP700.76820264
61BMX0.76048067
62PINK10.75236643
63KDR0.75143488
64MAP2K30.74963827
65ABL20.74127567
66NTRK10.73758178
67GSK3A0.71719843
68CAMK10.71645927
69TGFBR10.70275578
70HIPK20.69835812
71SMG10.69202804
72PRKG20.67819236
73CSK0.67499647
74PRKD10.66470656
75MAPK40.66180875
76TRPM70.66178774
77STK380.64506898
78PRKCH0.64410663
79JAK10.64361059
80INSRR0.63836395
81NEK10.63714171
82PAK20.62949795
83PRKD20.61551930
84ROCK20.60811273
85TYK20.60285076
86MAP3K70.59281429
87FLT30.59207570
88PRKD30.58248864
89PDPK10.58000482
90SGK4940.56455636
91SGK2230.56455636
92PHKG10.55009462
93PHKG20.55009462
94FGFR30.53243203
95MAPK120.53014434
96RPS6KC10.52788249
97RPS6KL10.52788249
98DMPK0.51112889
99GRK60.49989012
100MAP3K130.49902386
101TAOK10.49398593
102TBK10.49125287
103FGFR10.48919545
104CAMK2G0.48886107
105PDGFRB0.48863917
106KIT0.48039417
107MAPK110.48022208
108ROCK10.46063406
109JAK20.46005768
110ILK0.43710488
111RPS6KA40.42338696
112PIM20.41665579
113MAPKAPK20.41607782
114MOS0.41525331
115MAPKAPK30.41284899
116IRAK10.40678027
117MTOR0.40499330
118PIK3CG0.39725818
119RPS6KA60.37018067
120PRKAA10.36497339
121FGFR20.36252898
122KSR20.34324678
123PRKACG0.34222148
124IGF1R0.33469913
125SRC0.33128184
126SGK30.33102358
127CDK60.33083990
128INSR0.32646573
129RET0.32367425
130JAK30.32361690
131DAPK30.32028813
132MAP2K20.31895256
133TAOK20.30227383
134MAP3K10.30189494
135PAK10.27794434
136NLK0.27635442
137MAPK30.26616355
138CAMK2D0.25435596

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.12543354
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.11707653
3Fatty acid degradation_Homo sapiens_hsa000712.89949232
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67697957
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62841599
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.60245854
7Butanoate metabolism_Homo sapiens_hsa006502.54191814
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50672087
9PPAR signaling pathway_Homo sapiens_hsa033202.47438199
10Fatty acid metabolism_Homo sapiens_hsa012122.47396340
11Tryptophan metabolism_Homo sapiens_hsa003802.36337045
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.35721556
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18473462
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11873896
15Pyruvate metabolism_Homo sapiens_hsa006202.09629669
16Peroxisome_Homo sapiens_hsa041462.04844912
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.97841115
18Nitrogen metabolism_Homo sapiens_hsa009101.88917100
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85239195
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.82423242
21beta-Alanine metabolism_Homo sapiens_hsa004101.74232841
22Carbon metabolism_Homo sapiens_hsa012001.58598905
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57633727
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55444767
25Protein digestion and absorption_Homo sapiens_hsa049741.52645159
26Vitamin digestion and absorption_Homo sapiens_hsa049771.51782665
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.44720315
28Bile secretion_Homo sapiens_hsa049761.43570324
29Arginine biosynthesis_Homo sapiens_hsa002201.41081759
30ECM-receptor interaction_Homo sapiens_hsa045121.39783628
31Prion diseases_Homo sapiens_hsa050201.35033019
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33418542
33Complement and coagulation cascades_Homo sapiens_hsa046101.32070214
34Starch and sucrose metabolism_Homo sapiens_hsa005001.25109502
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23480194
36Notch signaling pathway_Homo sapiens_hsa043301.22860363
37Caffeine metabolism_Homo sapiens_hsa002321.18947505
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18047909
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.16750837
40Sulfur metabolism_Homo sapiens_hsa009201.12674375
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11514146
42Chemical carcinogenesis_Homo sapiens_hsa052041.11490064
43Glutathione metabolism_Homo sapiens_hsa004801.10637841
44Glycerolipid metabolism_Homo sapiens_hsa005611.09172242
45Arginine and proline metabolism_Homo sapiens_hsa003301.07481276
46Fatty acid elongation_Homo sapiens_hsa000621.06789154
47Lysine degradation_Homo sapiens_hsa003101.04461927
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.01887866
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99062500
50Phenylalanine metabolism_Homo sapiens_hsa003600.99043595
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97726167
52Pertussis_Homo sapiens_hsa051330.96995869
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94373561
54Fatty acid biosynthesis_Homo sapiens_hsa000610.90570688
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88963423
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.88807467
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85320497
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83646397
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82361683
60Histidine metabolism_Homo sapiens_hsa003400.82307154
61Focal adhesion_Homo sapiens_hsa045100.81850648
62Renin secretion_Homo sapiens_hsa049240.81745867
63Biosynthesis of amino acids_Homo sapiens_hsa012300.80849556
64Tight junction_Homo sapiens_hsa045300.79409009
65Tyrosine metabolism_Homo sapiens_hsa003500.79078669
66Selenocompound metabolism_Homo sapiens_hsa004500.78734163
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78716562
68Melanogenesis_Homo sapiens_hsa049160.78696443
69Axon guidance_Homo sapiens_hsa043600.78148561
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77878159
71Lysosome_Homo sapiens_hsa041420.72287458
72Other glycan degradation_Homo sapiens_hsa005110.71698024
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70714146
74GnRH signaling pathway_Homo sapiens_hsa049120.70618228
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69517211
76Acute myeloid leukemia_Homo sapiens_hsa052210.67732954
77Retinol metabolism_Homo sapiens_hsa008300.67693867
78Pathways in cancer_Homo sapiens_hsa052000.67681029
79Insulin resistance_Homo sapiens_hsa049310.66270473
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.66194979
81Basal cell carcinoma_Homo sapiens_hsa052170.64672624
82Small cell lung cancer_Homo sapiens_hsa052220.63516671
83TGF-beta signaling pathway_Homo sapiens_hsa043500.63329780
84Gap junction_Homo sapiens_hsa045400.62740353
85Estrogen signaling pathway_Homo sapiens_hsa049150.62279903
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61290242
87Mineral absorption_Homo sapiens_hsa049780.60970714
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60752631
89Malaria_Homo sapiens_hsa051440.60646091
90Melanoma_Homo sapiens_hsa052180.59582442
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59180796
92Rap1 signaling pathway_Homo sapiens_hsa040150.59080676
93Endocytosis_Homo sapiens_hsa041440.58997335
94Fat digestion and absorption_Homo sapiens_hsa049750.57448744
95Pentose phosphate pathway_Homo sapiens_hsa000300.57112299
96Chronic myeloid leukemia_Homo sapiens_hsa052200.56460160
97Folate biosynthesis_Homo sapiens_hsa007900.55714358
98Staphylococcus aureus infection_Homo sapiens_hsa051500.55496582
99Renal cell carcinoma_Homo sapiens_hsa052110.53813738
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51626373
101VEGF signaling pathway_Homo sapiens_hsa043700.51506437
102Hepatitis C_Homo sapiens_hsa051600.50280740
103AMPK signaling pathway_Homo sapiens_hsa041520.49998821
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48851387
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47776700
106Ras signaling pathway_Homo sapiens_hsa040140.47687017
107Toxoplasmosis_Homo sapiens_hsa051450.47273512
108Prostate cancer_Homo sapiens_hsa052150.47165155
109Phagosome_Homo sapiens_hsa041450.46763640
110TNF signaling pathway_Homo sapiens_hsa046680.46614680
111Fructose and mannose metabolism_Homo sapiens_hsa000510.46430751
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45157353
113Platelet activation_Homo sapiens_hsa046110.45078802
114Amoebiasis_Homo sapiens_hsa051460.45045880
115Thyroid hormone synthesis_Homo sapiens_hsa049180.44165615
116cAMP signaling pathway_Homo sapiens_hsa040240.43267074
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42415333
118Renin-angiotensin system_Homo sapiens_hsa046140.42239098
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.41839555
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39439595
121Thyroid cancer_Homo sapiens_hsa052160.38952746
122Prolactin signaling pathway_Homo sapiens_hsa049170.38569401
123Sulfur relay system_Homo sapiens_hsa041220.36513180
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35247355
125Proteoglycans in cancer_Homo sapiens_hsa052050.34845684
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.34492519
127Ovarian steroidogenesis_Homo sapiens_hsa049130.34004541
128Bladder cancer_Homo sapiens_hsa052190.32614993
129Arachidonic acid metabolism_Homo sapiens_hsa005900.32495843
130ABC transporters_Homo sapiens_hsa020100.31107295
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30731984
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29806782
133Collecting duct acid secretion_Homo sapiens_hsa049660.29378070
134Metabolic pathways_Homo sapiens_hsa011000.28642149
135Dilated cardiomyopathy_Homo sapiens_hsa054140.28376556
136Galactose metabolism_Homo sapiens_hsa000520.25443387
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24066979
138Glucagon signaling pathway_Homo sapiens_hsa049220.23086830
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19921185
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.19659791
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.18802851
142Insulin signaling pathway_Homo sapiens_hsa049100.17588545
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17136408
144Adherens junction_Homo sapiens_hsa045200.14904051

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