SOGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.66923541
2nucleobase catabolic process (GO:0046113)5.54921757
3behavioral response to nicotine (GO:0035095)4.71248346
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62281817
5protein localization to synapse (GO:0035418)4.55757871
6vocalization behavior (GO:0071625)4.51953751
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46792537
8neuron recognition (GO:0008038)4.44782355
9synaptic vesicle exocytosis (GO:0016079)4.41102283
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39906680
11presynaptic membrane assembly (GO:0097105)4.31774449
12neuronal action potential propagation (GO:0019227)4.26053100
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25451071
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.25216652
15presynaptic membrane organization (GO:0097090)4.15287950
16cell migration in hindbrain (GO:0021535)4.08752611
17glutamate receptor signaling pathway (GO:0007215)4.01274418
18regulation of synaptic vesicle exocytosis (GO:2000300)3.98515626
19axonal fasciculation (GO:0007413)3.98345891
20glutamate secretion (GO:0014047)3.96598843
21synaptic vesicle maturation (GO:0016188)3.94628178
22regulation of glutamate receptor signaling pathway (GO:1900449)3.92921963
23layer formation in cerebral cortex (GO:0021819)3.85849563
24locomotory exploration behavior (GO:0035641)3.81115988
25dendritic spine morphogenesis (GO:0060997)3.80186794
26synaptic transmission, glutamatergic (GO:0035249)3.75748770
27postsynaptic membrane organization (GO:0001941)3.73590981
28transmission of nerve impulse (GO:0019226)3.62820949
29central nervous system myelination (GO:0022010)3.58996897
30axon ensheathment in central nervous system (GO:0032291)3.58996897
31neuron-neuron synaptic transmission (GO:0007270)3.58330218
32spinal cord development (GO:0021510)3.55009542
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.54073396
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51953983
35dendrite morphogenesis (GO:0048813)3.50678578
36regulation of synaptic vesicle transport (GO:1902803)3.50059425
37exploration behavior (GO:0035640)3.49288539
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48833106
39calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.43643356
40establishment of mitochondrion localization (GO:0051654)3.42684169
41neurotransmitter-gated ion channel clustering (GO:0072578)3.41927611
42regulation of neuronal synaptic plasticity (GO:0048168)3.39399026
43neuromuscular synaptic transmission (GO:0007274)3.39178824
44retinal ganglion cell axon guidance (GO:0031290)3.37379733
45positive regulation of synapse assembly (GO:0051965)3.34795396
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.32388621
47central nervous system projection neuron axonogenesis (GO:0021952)3.30305130
48cerebral cortex radially oriented cell migration (GO:0021799)3.28527380
49ganglion development (GO:0061548)3.26563778
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25873811
51neurotransmitter secretion (GO:0007269)3.25682374
52gamma-aminobutyric acid transport (GO:0015812)3.25317467
53axon extension (GO:0048675)3.24447787
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23267945
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21584844
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19452963
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18683805
58regulation of synapse maturation (GO:0090128)3.18188080
59pyrimidine nucleobase catabolic process (GO:0006208)3.17336077
60synapse assembly (GO:0007416)3.16472195
61regulation of respiratory system process (GO:0044065)3.13690060
62positive regulation of membrane potential (GO:0045838)3.13502170
63regulation of synapse structural plasticity (GO:0051823)3.10979086
64regulation of postsynaptic membrane potential (GO:0060078)3.10946881
65establishment of nucleus localization (GO:0040023)3.10245156
66mating behavior (GO:0007617)3.09957482
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09455746
68sympathetic nervous system development (GO:0048485)3.08987884
69synaptic vesicle endocytosis (GO:0048488)3.08309144
70regulation of dendritic spine morphogenesis (GO:0061001)3.08141596
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05895425
72neuronal ion channel clustering (GO:0045161)3.05215300
73cerebellar Purkinje cell differentiation (GO:0021702)3.05115651
74cerebellar granule cell differentiation (GO:0021707)3.04878193
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.04829927
76negative regulation of neurotransmitter transport (GO:0051589)3.04548934
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.03122697
78hippocampus development (GO:0021766)3.02685791
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02561282
80adult walking behavior (GO:0007628)3.00772454
81regulation of vesicle fusion (GO:0031338)3.00505877
82positive regulation of synapse maturation (GO:0090129)3.00223378
83long-term memory (GO:0007616)2.99650458
84innervation (GO:0060384)2.96942155
85positive regulation of dendritic spine development (GO:0060999)2.96860047
86regulation of feeding behavior (GO:0060259)2.96573347
87regulation of neurotransmitter secretion (GO:0046928)2.96035880
88neuron migration (GO:0001764)2.95459725
89olfactory bulb development (GO:0021772)2.94706256
90membrane depolarization during action potential (GO:0086010)2.93540943
91auditory behavior (GO:0031223)2.92559744
92dendrite development (GO:0016358)2.91830979
93negative regulation of microtubule polymerization (GO:0031115)2.91509226
94regulation of respiratory gaseous exchange (GO:0043576)2.91007196
95neurotransmitter transport (GO:0006836)2.90674432
96negative regulation of dendrite development (GO:2000171)2.90363179
97membrane hyperpolarization (GO:0060081)2.88752883
98membrane depolarization (GO:0051899)2.87759585
99response to auditory stimulus (GO:0010996)2.84769452
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.84115382
101establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83842506
102mitochondrion transport along microtubule (GO:0047497)2.83842506
103regulation of synaptic plasticity (GO:0048167)2.83419620
104regulation of axon guidance (GO:1902667)2.82941247
105long-chain fatty acid biosynthetic process (GO:0042759)2.82471487
106regulation of synapse assembly (GO:0051963)2.82211160
107membrane assembly (GO:0071709)2.82157388
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81992996
109axonogenesis (GO:0007409)2.81874335
110long-term synaptic potentiation (GO:0060291)2.80986409
111synaptic transmission, cholinergic (GO:0007271)2.80948271
112central nervous system neuron axonogenesis (GO:0021955)2.80087020
113forebrain neuron differentiation (GO:0021879)2.79055656
114mechanosensory behavior (GO:0007638)2.79011002
115regulation of dendritic spine development (GO:0060998)2.78711423
116neuronal action potential (GO:0019228)2.77889186
117startle response (GO:0001964)2.77860664
118nonmotile primary cilium assembly (GO:0035058)2.77802766
119synapse organization (GO:0050808)2.77769836
120proline transport (GO:0015824)2.77354898
121learning (GO:0007612)2.76111498
122atrial cardiac muscle cell action potential (GO:0086014)2.76051859
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.75595147
124neurofilament cytoskeleton organization (GO:0060052)2.73389579
125substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72854266
126substrate-independent telencephalic tangential migration (GO:0021826)2.72854266
127regulation of axon extension involved in axon guidance (GO:0048841)2.72526784
128axon cargo transport (GO:0008088)2.71962583
129protein polyglutamylation (GO:0018095)2.71913421
130negative regulation of axonogenesis (GO:0050771)2.71236693
131heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.68597146
132behavioral response to ethanol (GO:0048149)2.68454117
133behavioral defense response (GO:0002209)2.67643301
134behavioral fear response (GO:0001662)2.67643301
135homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.64737562
136neuron projection extension (GO:1990138)2.62651518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86509369
2GBX2_23144817_ChIP-Seq_PC3_Human4.00044795
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12484402
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04135338
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90799072
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.76120673
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62607280
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61536184
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61536184
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52082479
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50806351
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49319993
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46277672
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.43302680
15REST_21632747_ChIP-Seq_MESCs_Mouse2.41218748
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31653330
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31571114
18TAF15_26573619_Chip-Seq_HEK293_Human2.29445903
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.28467285
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21863529
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.20532540
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02865566
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97778499
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96195012
25DROSHA_22980978_ChIP-Seq_HELA_Human1.92587691
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91566096
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91522319
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.89220168
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.89098050
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88601020
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88228010
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87530171
33AR_21572438_ChIP-Seq_LNCaP_Human1.84393847
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.78181191
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73728150
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73181991
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69865501
38IGF1R_20145208_ChIP-Seq_DFB_Human1.68151634
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67586656
40P300_19829295_ChIP-Seq_ESCs_Human1.65085571
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61910744
42SMAD4_21799915_ChIP-Seq_A2780_Human1.61318421
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56969210
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55458333
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51727333
46RNF2_27304074_Chip-Seq_NSC_Mouse1.51723341
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51363686
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49501664
49VDR_22108803_ChIP-Seq_LS180_Human1.48162511
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.45154765
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43658780
52ZNF274_21170338_ChIP-Seq_K562_Hela1.42050837
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41671526
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40493688
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.38401412
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36590185
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.30339457
58FUS_26573619_Chip-Seq_HEK293_Human1.27049473
59STAT3_23295773_ChIP-Seq_U87_Human1.24210452
60AR_25329375_ChIP-Seq_VCAP_Human1.23382150
61EWS_26573619_Chip-Seq_HEK293_Human1.23039590
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.22969328
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.22614966
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21693837
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.20853360
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20406545
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19035298
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18241237
69SOX9_26525672_Chip-Seq_HEART_Mouse1.17762555
70ER_23166858_ChIP-Seq_MCF-7_Human1.16756026
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16575586
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15221414
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15111151
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13122876
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12182838
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12003979
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12003979
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.11516861
79TCF4_23295773_ChIP-Seq_U87_Human1.09838575
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09526692
81RUNX2_22187159_ChIP-Seq_PCA_Human1.09248408
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09063778
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07660540
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07098055
85CBP_20019798_ChIP-Seq_JUKART_Human1.07098055
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06282520
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05999875
88AHR_22903824_ChIP-Seq_MCF-7_Human1.05935561
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.04955286
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04898330
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04789089
92AR_19668381_ChIP-Seq_PC3_Human1.03659606
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03213179
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.02395790
95JUN_21703547_ChIP-Seq_K562_Human1.02286120
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.00841818
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.00730449
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00270991
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00036250
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99780581
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99032053
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98821611
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98666738
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98358377
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98219022
106IRF1_19129219_ChIP-ChIP_H3396_Human0.97177017
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96281434
108TAL1_26923725_Chip-Seq_HPCs_Mouse0.95340587
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94660750
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91781459
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.90269514
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90064720
113TP53_18474530_ChIP-ChIP_U2OS_Human0.89982256
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89436402
115KDM2B_26808549_Chip-Seq_REH_Human0.88980506
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88952023
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87874062
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.87379796
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87193392
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.86392717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.89957404
2MP0004859_abnormal_synaptic_plasticity4.52500977
3MP0004270_analgesia3.76602699
4MP0003635_abnormal_synaptic_transmissio3.37059969
5MP0005423_abnormal_somatic_nervous3.30988457
6MP0001968_abnormal_touch/_nociception2.94613759
7MP0009745_abnormal_behavioral_response2.80205525
8MP0002063_abnormal_learning/memory/cond2.78842026
9MP0002735_abnormal_chemical_nociception2.76737018
10MP0002734_abnormal_mechanical_nocicepti2.72143313
11MP0002064_seizures2.65608264
12MP0006276_abnormal_autonomic_nervous2.59381283
13MP0009046_muscle_twitch2.58228533
14MP0000778_abnormal_nervous_system2.58195637
15MP0002272_abnormal_nervous_system2.50090881
16MP0002572_abnormal_emotion/affect_behav2.49295324
17MP0001486_abnormal_startle_reflex2.44711492
18MP0003121_genomic_imprinting2.44277935
19MP0002736_abnormal_nociception_after2.39331754
20MP0002733_abnormal_thermal_nociception2.24441971
21MP0002184_abnormal_innervation2.15392698
22MP0001970_abnormal_pain_threshold2.04332582
23MP0001440_abnormal_grooming_behavior2.03626307
24MP0002067_abnormal_sensory_capabilities2.00786321
25MP0001984_abnormal_olfaction1.93444156
26MP0001529_abnormal_vocalization1.85594671
27MP0002822_catalepsy1.81953031
28MP0002557_abnormal_social/conspecific_i1.76051815
29MP0004858_abnormal_nervous_system1.73155831
30MP0005645_abnormal_hypothalamus_physiol1.72884892
31MP0000955_abnormal_spinal_cord1.71716294
32MP0003329_amyloid_beta_deposits1.68553077
33MP0005386_behavior/neurological_phenoty1.65406188
34MP0004924_abnormal_behavior1.65406188
35MP0001501_abnormal_sleep_pattern1.63394021
36MP0001188_hyperpigmentation1.61532962
37MP0002882_abnormal_neuron_morphology1.61087124
38MP0002653_abnormal_ependyma_morphology1.60669287
39MP0004742_abnormal_vestibular_system1.60428018
40MP0004142_abnormal_muscle_tone1.58825457
41MP0004811_abnormal_neuron_physiology1.55400307
42MP0001905_abnormal_dopamine_level1.54727638
43MP0004885_abnormal_endolymph1.51214774
44MP0004133_heterotaxia1.40521892
45MP0005646_abnormal_pituitary_gland1.40341265
46MP0008569_lethality_at_weaning1.39957178
47MP0002066_abnormal_motor_capabilities/c1.37148361
48MP0003787_abnormal_imprinting1.34502370
49MP0001485_abnormal_pinna_reflex1.31319849
50MP0005551_abnormal_eye_electrophysiolog1.29523990
51MP0003123_paternal_imprinting1.25174088
52MP0001502_abnormal_circadian_rhythm1.25140013
53MP0000920_abnormal_myelination1.24540461
54MP0002752_abnormal_somatic_nervous1.22990447
55MP0002152_abnormal_brain_morphology1.22219540
56MP0005394_taste/olfaction_phenotype1.19688844
57MP0005499_abnormal_olfactory_system1.19688844
58MP0002229_neurodegeneration1.18375852
59MP0001986_abnormal_taste_sensitivity1.18078091
60MP0003122_maternal_imprinting1.17264600
61MP0010386_abnormal_urinary_bladder1.16775991
62MP0009780_abnormal_chondrocyte_physiolo1.16684796
63MP0008877_abnormal_DNA_methylation1.14716209
64MP0003634_abnormal_glial_cell1.13915675
65MP0000631_abnormal_neuroendocrine_gland1.13832379
66MP0001963_abnormal_hearing_physiology1.11806317
67MP0005409_darkened_coat_color1.11455980
68MP0002751_abnormal_autonomic_nervous1.08455891
69MP0003890_abnormal_embryonic-extraembry1.07629346
70MP0003879_abnormal_hair_cell1.06817031
71MP0003633_abnormal_nervous_system1.04994641
72MP0002909_abnormal_adrenal_gland1.04370406
73MP0002638_abnormal_pupillary_reflex1.01547369
74MP0008789_abnormal_olfactory_epithelium1.00692364
75MP0005187_abnormal_penis_morphology1.00275162
76MP0003631_nervous_system_phenotype1.00065452
77MP0006292_abnormal_olfactory_placode0.98830628
78MP0006072_abnormal_retinal_apoptosis0.97216298
79MP0004145_abnormal_muscle_electrophysio0.96368495
80MP0002102_abnormal_ear_morphology0.96361569
81MP0005171_absent_coat_pigmentation0.95488622
82MP0000026_abnormal_inner_ear0.93772486
83MP0002234_abnormal_pharynx_morphology0.91826589
84MP0003283_abnormal_digestive_organ0.90849279
85MP0003937_abnormal_limbs/digits/tail_de0.89557336
86MP0003119_abnormal_digestive_system0.88090895
87MP0003861_abnormal_nervous_system0.88059805
88MP0002081_perinatal_lethality0.84305778
89MP0003632_abnormal_nervous_system0.84258464
90MP0003136_yellow_coat_color0.83657635
91MP0002069_abnormal_eating/drinking_beha0.82835261
92MP0003938_abnormal_ear_development0.81260367
93MP0002233_abnormal_nose_morphology0.80334510
94MP0002837_dystrophic_cardiac_calcinosis0.78476615
95MP0003755_abnormal_palate_morphology0.76399189
96MP0003942_abnormal_urinary_system0.75822101
97MP0003137_abnormal_impulse_conducting0.75164967
98MP0004085_abnormal_heartbeat0.74879721
99MP0000751_myopathy0.74334041
100MP0005391_vision/eye_phenotype0.74131954
101MP0001299_abnormal_eye_distance/0.73345925
102MP0000534_abnormal_ureter_morphology0.72003407
103MP0005248_abnormal_Harderian_gland0.71441750
104MP0001293_anophthalmia0.69850106
105MP0005253_abnormal_eye_physiology0.69055356
106MP0010769_abnormal_survival0.68092868
107MP0000516_abnormal_urinary_system0.67328988
108MP0003690_abnormal_glial_cell0.66245777
109MP0005195_abnormal_posterior_eye0.65649016
110MP0001664_abnormal_digestion0.64555482
111MP0001943_abnormal_respiration0.63116412
112MP0009379_abnormal_foot_pigmentation0.63046148
113MP0001177_atelectasis0.61592908
114MP0000537_abnormal_urethra_morphology0.58955835
115MP0003183_abnormal_peptide_metabolism0.58452511
116MP0000013_abnormal_adipose_tissue0.56679765
117MP0010770_preweaning_lethality0.56024146
118MP0002082_postnatal_lethality0.56024146
119MP0000569_abnormal_digit_pigmentation0.55778609
120MP0008874_decreased_physiological_sensi0.55298574
121MP0000604_amyloidosis0.55249487
122MP0000049_abnormal_middle_ear0.54208914

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.84202571
2Myokymia (HP:0002411)5.44412418
3Focal seizures (HP:0007359)4.49792778
4Epileptic encephalopathy (HP:0200134)4.38178050
5Atonic seizures (HP:0010819)4.06699841
6Febrile seizures (HP:0002373)3.78465687
7Supranuclear gaze palsy (HP:0000605)3.75644274
8Progressive cerebellar ataxia (HP:0002073)3.69566188
9Hyperventilation (HP:0002883)3.57474152
10Neurofibrillary tangles (HP:0002185)3.39203216
11Limb dystonia (HP:0002451)3.35623449
12Visual hallucinations (HP:0002367)3.31530764
13Absence seizures (HP:0002121)3.27574658
14Abnormality of the corticospinal tract (HP:0002492)3.26286711
15Broad-based gait (HP:0002136)3.20914292
16Action tremor (HP:0002345)3.13958130
17Dialeptic seizures (HP:0011146)3.09230544
18Ankle clonus (HP:0011448)3.04803532
19Termporal pattern (HP:0011008)3.00916754
20Insidious onset (HP:0003587)3.00916754
21Cerebral inclusion bodies (HP:0100314)2.98744662
22Generalized tonic-clonic seizures (HP:0002069)2.97592243
23Hepatoblastoma (HP:0002884)2.97193139
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.96700607
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96700607
26Drooling (HP:0002307)2.93604750
27Excessive salivation (HP:0003781)2.93604750
28Amblyopia (HP:0000646)2.87545043
29Abnormality of the labia minora (HP:0012880)2.84498621
30Cortical dysplasia (HP:0002539)2.77190240
31Pachygyria (HP:0001302)2.77089087
32Truncal ataxia (HP:0002078)2.71680514
33Spastic gait (HP:0002064)2.70061351
34Gaze-evoked nystagmus (HP:0000640)2.58331097
35Progressive inability to walk (HP:0002505)2.55571872
36Epileptiform EEG discharges (HP:0011182)2.54544957
37Retinal dysplasia (HP:0007973)2.54424548
38Gait imbalance (HP:0002141)2.54209168
39Dysmetria (HP:0001310)2.54198207
40Polyphagia (HP:0002591)2.51928398
41Pheochromocytoma (HP:0002666)2.51800420
42Hemiparesis (HP:0001269)2.50678784
43EEG with generalized epileptiform discharges (HP:0011198)2.48140701
44Abnormal eating behavior (HP:0100738)2.46850946
45Absent speech (HP:0001344)2.44864928
46Poor eye contact (HP:0000817)2.37099797
47Mutism (HP:0002300)2.35281635
48Urinary bladder sphincter dysfunction (HP:0002839)2.33949013
49Hypsarrhythmia (HP:0002521)2.32595636
50Intestinal atresia (HP:0011100)2.32069878
51Nephronophthisis (HP:0000090)2.29437443
52Shawl scrotum (HP:0000049)2.28123353
53Dysdiadochokinesis (HP:0002075)2.27642721
54Specific learning disability (HP:0001328)2.26941025
55Short 4th metacarpal (HP:0010044)2.26571950
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26571950
57Anxiety (HP:0000739)2.26040375
58Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25661766
59Hypoplasia of the brainstem (HP:0002365)2.25661766
60Scanning speech (HP:0002168)2.25573210
61Poor suck (HP:0002033)2.24214769
62Impaired vibration sensation in the lower limbs (HP:0002166)2.24179669
63Ulnar claw (HP:0001178)2.23716003
64Narrow forehead (HP:0000341)2.22450811
65Agitation (HP:0000713)2.22438559
66Neuroendocrine neoplasm (HP:0100634)2.21902729
67Peripheral hypomyelination (HP:0007182)2.20645457
68Megalencephaly (HP:0001355)2.20574758
69Urinary urgency (HP:0000012)2.19502357
70Abnormal hair whorl (HP:0010721)2.17108233
71Akinesia (HP:0002304)2.15380688
72Lower limb muscle weakness (HP:0007340)2.14491738
73Abnormality of salivation (HP:0100755)2.13193687
74Inability to walk (HP:0002540)2.13056281
75Thickened helices (HP:0000391)2.11289685
76Molar tooth sign on MRI (HP:0002419)2.09808674
77Abnormality of midbrain morphology (HP:0002418)2.09808674
78Medial flaring of the eyebrow (HP:0010747)2.07626801
79Depression (HP:0000716)2.05238456
80Fetal akinesia sequence (HP:0001989)2.04869464
81Impaired social interactions (HP:0000735)2.03801615
82Abnormal social behavior (HP:0012433)2.03801615
83Pancreatic fibrosis (HP:0100732)2.03656711
84Exotropia (HP:0000577)2.03594682
85Chronic hepatic failure (HP:0100626)2.02950065
86Genital tract atresia (HP:0001827)2.02805006
87Oligodactyly (hands) (HP:0001180)2.01948977
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.01024436
89Absent/shortened dynein arms (HP:0200106)2.01024436
90Hypoplasia of the corpus callosum (HP:0002079)2.00011269
91Hypothermia (HP:0002045)1.99958301
92Vaginal atresia (HP:0000148)1.99432450
93Spastic tetraplegia (HP:0002510)1.99420505
94Sensory axonal neuropathy (HP:0003390)1.99153800
95Blue irides (HP:0000635)1.98782303
96Congenital primary aphakia (HP:0007707)1.98010565
97High anterior hairline (HP:0009890)1.96931280
98Esotropia (HP:0000565)1.96164045
99Type II lissencephaly (HP:0007260)1.95385771
100Cutaneous finger syndactyly (HP:0010554)1.95198925
101Amyotrophic lateral sclerosis (HP:0007354)1.95073465
102Protruding tongue (HP:0010808)1.93083435
103Abnormality of the 4th metacarpal (HP:0010012)1.91854475
104Hypoventilation (HP:0002791)1.90782020
105Lissencephaly (HP:0001339)1.90530514
106Hip dysplasia (HP:0001385)1.89393669
107Poor coordination (HP:0002370)1.89189939
108Abnormality of the renal medulla (HP:0100957)1.88385009
109True hermaphroditism (HP:0010459)1.87359691
110Abnormality of binocular vision (HP:0011514)1.87223781
111Diplopia (HP:0000651)1.87223781
112Nephrogenic diabetes insipidus (HP:0009806)1.86851540
113Pancreatic cysts (HP:0001737)1.86293929
114Aqueductal stenosis (HP:0002410)1.84358750
115Failure to thrive in infancy (HP:0001531)1.83977695
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83124012
117Renal hypoplasia (HP:0000089)1.83079288
118Hyperthyroidism (HP:0000836)1.82548402
119Abnormal ciliary motility (HP:0012262)1.81730815
120Septo-optic dysplasia (HP:0100842)1.81679836
121Vitreoretinal degeneration (HP:0000655)1.81461385
122Genetic anticipation (HP:0003743)1.81320406
123Optic nerve hypoplasia (HP:0000609)1.80881490
124Widely spaced teeth (HP:0000687)1.79710066
125Stereotypic behavior (HP:0000733)1.78279534
126Cutaneous syndactyly (HP:0012725)1.78251794
127Generalized myoclonic seizures (HP:0002123)1.77500743
128Volvulus (HP:0002580)1.75765049
129Intention tremor (HP:0002080)1.75397382
130Neoplasm of the adrenal cortex (HP:0100641)1.75371317
131Tented upper lip vermilion (HP:0010804)1.74275741
132Morphological abnormality of the pyramidal tract (HP:0002062)1.74254708
133Postaxial hand polydactyly (HP:0001162)1.72995817
134Gastroesophageal reflux (HP:0002020)1.71469107
135Sleep apnea (HP:0010535)1.71389612
136Micropenis (HP:0000054)1.70949169
137Abnormality of the lower motor neuron (HP:0002366)1.70070630
138Intellectual disability, severe (HP:0010864)1.69462476
139Torticollis (HP:0000473)1.69341221
140Aplasia involving bones of the extremities (HP:0009825)1.67305526
141Aplasia of the phalanges of the hand (HP:0009802)1.67305526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.33327364
2NTRK33.79715113
3CASK3.67411002
4EPHA43.19374597
5MAP3K42.59440104
6MAP3K92.52388887
7TNIK2.41245803
8MAP2K72.39624251
9MINK12.37498738
10NTRK22.27602617
11MAPK132.23249234
12PNCK2.20372878
13NTRK11.94084803
14PAK61.83945876
15STK391.77703281
16PHKG21.71758341
17PHKG11.71758341
18EPHB21.68272389
19EPHA31.57904979
20OXSR11.55861505
21UHMK11.54991426
22DAPK21.48550757
23CDK51.42967246
24DYRK21.40585116
25MAP4K21.39407636
26CCNB11.34826273
27PRPF4B1.32637364
28PINK11.32371980
29MAP2K41.32053415
30FRK1.29708504
31PLK21.29080391
32KSR11.27402988
33SIK21.26804423
34MAP3K121.25364908
35ARAF1.23891524
36GRK51.23345985
37SGK2231.23051952
38SGK4941.23051952
39BCR1.22604414
40CDK191.19575144
41CSNK1G21.19191046
42CAMK2B1.15772597
43PRKD31.13590356
44PKN11.11608275
45PRKCG1.10154786
46KSR21.10060477
47CAMK2A1.09954697
48CAMK1D1.06585535
49ZAK1.02750083
50TRIM281.01783638
51CSNK1G30.98526310
52LIMK10.96789575
53DYRK1B0.94460730
54DYRK1A0.89950495
55FGR0.89413677
56CDK140.89317813
57RIPK40.87179834
58FES0.87168922
59LATS20.87039569
60PAK30.86653202
61CDK180.85679764
62WNK30.83094267
63BMPR1B0.82534129
64CDK150.81525841
65CSNK1A1L0.81361550
66CAMK2D0.78817385
67MKNK20.78330249
68WNK40.76604240
69PRKCE0.76393899
70ROCK20.73803101
71LATS10.73572045
72TAOK10.72953153
73WNK10.72302424
74MARK20.71486204
75CDK11A0.71291346
76IRAK20.69732311
77MAP3K20.68686982
78DAPK10.68639775
79SGK20.68462112
80NME10.65095923
81STK110.64414130
82CAMKK10.64215476
83CSNK1G10.64090861
84MUSK0.63639620
85BMPR20.61025365
86STK160.60231996
87CAMK2G0.60148128
88BRAF0.59344134
89CAMKK20.58768151
90TYRO30.58234871
91CSNK1E0.58166387
92RET0.56235182
93PRKCZ0.55949934
94FGFR20.54629100
95SGK10.54099343
96MAPKAPK50.54041724
97PTK2B0.53708619
98SRPK10.53648234
99SIK30.53374815
100NUAK10.53294199
101ADRBK20.52686744
102LMTK20.52199547
103RPS6KA20.51877369
104ERBB30.50742728
105GRK70.49853460
106CSNK1D0.49769334
107DYRK30.49746316
108ADRBK10.49327361
109CAMK40.47089370
110NEK60.47059421
111PRKG10.46229234
112AKT30.44551744
113FER0.43662919
114PRKAA10.43329666
115CAMK10.43308670
116CAMK1G0.43087211
117CDK30.41576297
118FYN0.41203059
119PRKCH0.40903867
120PRKACA0.40545931
121INSRR0.40455911
122SGK30.38313992
123GSK3B0.37677917
124CSNK1A10.37630024
125PRKDC0.37046358
126RPS6KA30.36940985
127PIM20.35578989
128BRD40.35285910
129ERBB20.34418528
130MAPK90.33616375
131GRK10.31649635
132STK38L0.30370743

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77374512
2Synaptic vesicle cycle_Homo sapiens_hsa047212.91520689
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75449163
4GABAergic synapse_Homo sapiens_hsa047272.68636505
5Glutamatergic synapse_Homo sapiens_hsa047242.62769539
6Circadian entrainment_Homo sapiens_hsa047132.53556844
7Morphine addiction_Homo sapiens_hsa050322.50112182
8Olfactory transduction_Homo sapiens_hsa047402.47714560
9Taste transduction_Homo sapiens_hsa047422.26368748
10Dopaminergic synapse_Homo sapiens_hsa047282.21033094
11Long-term potentiation_Homo sapiens_hsa047202.17406955
12Serotonergic synapse_Homo sapiens_hsa047262.15136132
13Amphetamine addiction_Homo sapiens_hsa050312.13335702
14Salivary secretion_Homo sapiens_hsa049701.89773429
15Cholinergic synapse_Homo sapiens_hsa047251.89285719
16Axon guidance_Homo sapiens_hsa043601.88483498
17Insulin secretion_Homo sapiens_hsa049111.88118229
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82734826
19Long-term depression_Homo sapiens_hsa047301.81120195
20Cocaine addiction_Homo sapiens_hsa050301.73360447
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69005155
22Collecting duct acid secretion_Homo sapiens_hsa049661.61640407
23Renin secretion_Homo sapiens_hsa049241.59190425
24Gastric acid secretion_Homo sapiens_hsa049711.53491473
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48882201
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47085350
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46492747
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45728264
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42319510
30Oxytocin signaling pathway_Homo sapiens_hsa049211.40855896
31Phototransduction_Homo sapiens_hsa047441.40657931
32Gap junction_Homo sapiens_hsa045401.38747366
33Calcium signaling pathway_Homo sapiens_hsa040201.38444207
34Oxidative phosphorylation_Homo sapiens_hsa001901.28556342
35Cardiac muscle contraction_Homo sapiens_hsa042601.25104392
36GnRH signaling pathway_Homo sapiens_hsa049121.20754732
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20438892
38Alzheimers disease_Homo sapiens_hsa050101.17287701
39Hippo signaling pathway_Homo sapiens_hsa043901.14861609
40cAMP signaling pathway_Homo sapiens_hsa040241.10576865
41ErbB signaling pathway_Homo sapiens_hsa040121.09634081
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08738570
43Vibrio cholerae infection_Homo sapiens_hsa051101.06204260
44Melanogenesis_Homo sapiens_hsa049161.06015018
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01945984
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01149115
47Estrogen signaling pathway_Homo sapiens_hsa049151.00667280
48Basal cell carcinoma_Homo sapiens_hsa052170.98934507
49Parkinsons disease_Homo sapiens_hsa050120.98840006
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97375695
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94945148
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.92052534
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91738055
54Type II diabetes mellitus_Homo sapiens_hsa049300.90615219
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87824669
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86133006
57Dorso-ventral axis formation_Homo sapiens_hsa043200.85158767
58Glioma_Homo sapiens_hsa052140.82399278
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.81304826
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78803437
61Ether lipid metabolism_Homo sapiens_hsa005650.77915883
62Pancreatic secretion_Homo sapiens_hsa049720.77183632
63Alcoholism_Homo sapiens_hsa050340.75688522
64Ras signaling pathway_Homo sapiens_hsa040140.74959644
65Protein export_Homo sapiens_hsa030600.74642293
66Choline metabolism in cancer_Homo sapiens_hsa052310.72952407
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72337210
68Huntingtons disease_Homo sapiens_hsa050160.69209400
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68241946
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68112278
71Renal cell carcinoma_Homo sapiens_hsa052110.65883773
72Steroid biosynthesis_Homo sapiens_hsa001000.65708552
73MAPK signaling pathway_Homo sapiens_hsa040100.65106981
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64040612
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63487667
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.63227577
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62509906
78Wnt signaling pathway_Homo sapiens_hsa043100.61470809
79Oocyte meiosis_Homo sapiens_hsa041140.60949770
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59926748
81AMPK signaling pathway_Homo sapiens_hsa041520.56874187
82Lysine degradation_Homo sapiens_hsa003100.56717912
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56343999
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55690892
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55464788
86Hedgehog signaling pathway_Homo sapiens_hsa043400.53526295
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53501476
88Thyroid hormone synthesis_Homo sapiens_hsa049180.52892526
89Rap1 signaling pathway_Homo sapiens_hsa040150.51038692
90Dilated cardiomyopathy_Homo sapiens_hsa054140.50265151
91Tight junction_Homo sapiens_hsa045300.49877968
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48054801
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.46608132
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.46559731
95mRNA surveillance pathway_Homo sapiens_hsa030150.45972167
96Ovarian steroidogenesis_Homo sapiens_hsa049130.45518526
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44286271
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43665363
99Endometrial cancer_Homo sapiens_hsa052130.43501838
100Basal transcription factors_Homo sapiens_hsa030220.43213228
101Fatty acid elongation_Homo sapiens_hsa000620.42586263
102Prion diseases_Homo sapiens_hsa050200.41700899
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41107477
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41067874
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39862411
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39645593
107VEGF signaling pathway_Homo sapiens_hsa043700.39272667
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38984337
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38280984
110Endocytosis_Homo sapiens_hsa041440.38133562
111Fatty acid biosynthesis_Homo sapiens_hsa000610.37272497
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36150741
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34826070
114Butanoate metabolism_Homo sapiens_hsa006500.34582556
115Melanoma_Homo sapiens_hsa052180.33023664
116Sphingolipid metabolism_Homo sapiens_hsa006000.32859818
117Circadian rhythm_Homo sapiens_hsa047100.32432926
118Regulation of autophagy_Homo sapiens_hsa041400.32126470
119Colorectal cancer_Homo sapiens_hsa052100.31566686
120Phagosome_Homo sapiens_hsa041450.31190929

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