SOHLH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.45641362
2synaptic vesicle docking involved in exocytosis (GO:0016081)9.23810777
3positive regulation of meiosis (GO:0045836)8.62382974
4synaptic vesicle maturation (GO:0016188)8.52195046
5glutamate secretion (GO:0014047)8.43378923
6positive regulation of meiotic cell cycle (GO:0051446)8.06021019
7meiotic nuclear division (GO:0007126)7.56323590
8chromosome organization involved in meiosis (GO:0070192)7.49718052
9synaptic vesicle exocytosis (GO:0016079)7.39551558
10gene silencing by RNA (GO:0031047)7.05903798
11regulation of short-term neuronal synaptic plasticity (GO:0048172)7.02881818
12regulation of synaptic vesicle exocytosis (GO:2000300)6.80476720
13sex differentiation (GO:0007548)6.76294828
14positive regulation of male gonad development (GO:2000020)6.65675764
15DNA methylation (GO:0006306)6.51529988
16DNA alkylation (GO:0006305)6.51529988
17negative regulation of meiosis (GO:0045835)6.41024298
18male meiosis I (GO:0007141)6.33721169
19oocyte development (GO:0048599)6.03976643
20regulation of synaptic vesicle transport (GO:1902803)5.95793302
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91777761
22meiotic chromosome segregation (GO:0045132)5.91472430
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.89089220
24neurotransmitter secretion (GO:0007269)5.83873036
25regulation of male gonad development (GO:2000018)5.78281021
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.56304392
27regulation of neuronal synaptic plasticity (GO:0048168)5.45828256
28meiotic cell cycle process (GO:1903046)5.32950846
29meiosis I (GO:0007127)5.31767276
30reciprocal DNA recombination (GO:0035825)5.24921741
31reciprocal meiotic recombination (GO:0007131)5.24921741
32regulation of meiosis (GO:0040020)5.23059398
33cellular potassium ion homeostasis (GO:0030007)5.22978416
34heterochromatin organization (GO:0070828)5.21791802
35gene silencing (GO:0016458)5.09323298
36positive regulation of dendritic spine morphogenesis (GO:0061003)5.03906823
37positive regulation of dendritic spine development (GO:0060999)5.01815143
38male sex determination (GO:0030238)4.99344917
39nuclear pore organization (GO:0006999)4.98851767
40* oogenesis (GO:0048477)4.96422819
41nuclear pore complex assembly (GO:0051292)4.93085071
42DNA methylation or demethylation (GO:0044728)4.88525068
43positive regulation of translational initiation (GO:0045948)4.85708712
44L-amino acid import (GO:0043092)4.84572672
45sex determination (GO:0007530)4.83199471
46regulation of long-term neuronal synaptic plasticity (GO:0048169)4.81132895
47locomotory exploration behavior (GO:0035641)4.78677581
48positive regulation of synapse maturation (GO:0090129)4.77700041
49exploration behavior (GO:0035640)4.76667683
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65578989
51neuronal action potential propagation (GO:0019227)4.59718210
52attachment of spindle microtubules to kinetochore (GO:0008608)4.56026779
53mitotic chromosome condensation (GO:0007076)4.55711809
54DNA synthesis involved in DNA repair (GO:0000731)4.53922751
55neurotransmitter transport (GO:0006836)4.52883987
56sodium ion export (GO:0071436)4.50552243
57germ cell migration (GO:0008354)4.49335310
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.46449105
59regulation of glutamate receptor signaling pathway (GO:1900449)4.38139983
60central nervous system myelination (GO:0022010)4.36612580
61axon ensheathment in central nervous system (GO:0032291)4.36612580
62regulation of synaptic plasticity (GO:0048167)4.34911065
63oocyte maturation (GO:0001556)4.31413066
64regulation of voltage-gated calcium channel activity (GO:1901385)4.27173178
65regulation of dendritic spine morphogenesis (GO:0061001)4.26988956
66protein localization to synapse (GO:0035418)4.24960030
67ionotropic glutamate receptor signaling pathway (GO:0035235)4.20460274
68sister chromatid cohesion (GO:0007062)4.20190043
69regulation of neurotransmitter secretion (GO:0046928)4.19400144
70regulation of meiotic cell cycle (GO:0051445)4.19305200
71* female gamete generation (GO:0007292)4.19223056
72gonadal mesoderm development (GO:0007506)4.17393934
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16508971
74histone H4-K12 acetylation (GO:0043983)4.16470177
75vocalization behavior (GO:0071625)4.15325688
76synaptic transmission, glutamatergic (GO:0035249)4.13090046
77amino acid import (GO:0043090)4.12079036
78resolution of meiotic recombination intermediates (GO:0000712)4.09504644
79regulation of neurotransmitter levels (GO:0001505)4.08356673
80negative regulation of dendrite morphogenesis (GO:0050774)4.08280796
81regulation of dendritic spine development (GO:0060998)4.05474869
82cerebellar granule cell differentiation (GO:0021707)3.99438990
83positive regulation of membrane potential (GO:0045838)3.98969391
84synaptic vesicle endocytosis (GO:0048488)3.95606677
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95498544
86positive regulation of neurotransmitter secretion (GO:0001956)3.93490372
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92644967
88regulation of synapse structural plasticity (GO:0051823)3.91849588
89neuronal ion channel clustering (GO:0045161)3.91839034
90DNA modification (GO:0006304)3.91200396
91positive regulation of neurotransmitter transport (GO:0051590)3.87261032
92synapsis (GO:0007129)3.86193002
93positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83389247
94negative regulation of meiotic cell cycle (GO:0051447)3.77074534
95peptidyl-lysine dimethylation (GO:0018027)3.74600491
96regulation of neurotransmitter transport (GO:0051588)3.73141090
97neuromuscular process controlling balance (GO:0050885)3.73084670
98dendritic spine morphogenesis (GO:0060997)3.71117269
99neuron-neuron synaptic transmission (GO:0007270)3.70067781
100gamma-aminobutyric acid signaling pathway (GO:0007214)3.69577717
101regulation of synapse maturation (GO:0090128)3.68920571
102cerebellar Purkinje cell differentiation (GO:0021702)3.68531507
103regulation of ARF protein signal transduction (GO:0032012)3.66411312
104phosphorelay signal transduction system (GO:0000160)3.65063345
105regulation of female receptivity (GO:0045924)3.64634447
106regulation of vesicle fusion (GO:0031338)3.63519043
107potassium ion homeostasis (GO:0055075)3.63318495
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63058067
109regulation of postsynaptic membrane potential (GO:0060078)3.60920482
110pore complex assembly (GO:0046931)3.60194373
111potassium ion import (GO:0010107)3.59209531
112meiotic cell cycle (GO:0051321)3.57659782
113positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.57203391
114* germ cell development (GO:0007281)3.56934061
115gamma-aminobutyric acid transport (GO:0015812)3.55622463
116transmission of nerve impulse (GO:0019226)3.51476548
117dendritic spine organization (GO:0097061)3.50007078
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.48964278
119long-term memory (GO:0007616)3.45548764
120neurotransmitter-gated ion channel clustering (GO:0072578)3.44625218
121protein K6-linked ubiquitination (GO:0085020)3.41628958
122histone H4-K5 acetylation (GO:0043981)3.40611580
123histone H4-K8 acetylation (GO:0043982)3.40611580
124histone H3-K9 methylation (GO:0051567)3.35158154
125regulation of double-strand break repair via homologous recombination (GO:0010569)3.34612084
126regulation of synaptic transmission (GO:0050804)3.34030744
127glutamate receptor signaling pathway (GO:0007215)3.33721244
128sleep (GO:0030431)3.33018778
129postsynaptic membrane organization (GO:0001941)3.31275608
130DNA replication checkpoint (GO:0000076)3.29614544
131membrane depolarization (GO:0051899)3.26819040
132long-term synaptic potentiation (GO:0060291)3.25932152
133neuromuscular synaptic transmission (GO:0007274)3.25755347
134negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.22711818
135DNA replication-dependent nucleosome organization (GO:0034723)3.19727347
136DNA replication-dependent nucleosome assembly (GO:0006335)3.19727347
137negative regulation of inclusion body assembly (GO:0090084)3.19127870
138layer formation in cerebral cortex (GO:0021819)3.18004532
139membrane depolarization during action potential (GO:0086010)3.16537218
140regulation of exocytosis (GO:0017157)3.16520826
141vesicle docking involved in exocytosis (GO:0006904)3.15871174
142synaptic transmission (GO:0007268)3.15358986
143calcium ion-dependent exocytosis (GO:0017156)3.14475092
144mitotic spindle assembly checkpoint (GO:0007094)3.14330215
145dicarboxylic acid transport (GO:0006835)3.14175558
146acidic amino acid transport (GO:0015800)3.12928565
147acid secretion (GO:0046717)3.12710354
148positive regulation of dendrite development (GO:1900006)3.12626403
149chromatin assembly (GO:0031497)3.12008428
150Sertoli cell development (GO:0060009)3.11228947
151synaptic vesicle transport (GO:0048489)3.10282511
152establishment of synaptic vesicle localization (GO:0097480)3.10282511
153negative regulation of nuclear division (GO:0051784)3.08528843
154snRNA metabolic process (GO:0016073)3.07312049
155female mating behavior (GO:0060180)3.07103868
156spindle assembly checkpoint (GO:0071173)3.04895710
157behavioral defense response (GO:0002209)3.04582272
158behavioral fear response (GO:0001662)3.04582272
159cell communication by electrical coupling (GO:0010644)3.04092479
160vesicle docking (GO:0048278)3.03818230
161neuromuscular process controlling posture (GO:0050884)3.03592336
162negative regulation of chromosome segregation (GO:0051985)3.02803755
163* male gamete generation (GO:0048232)3.01929672
164* spermatogenesis (GO:0007283)3.01789040
165mitotic spindle checkpoint (GO:0071174)2.99535758
166macroautophagy (GO:0016236)2.99370955
167kinetochore assembly (GO:0051382)2.96968427
168regulation of histone H3-K9 methylation (GO:0051570)2.96214843
169negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95924498
170negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95924498
171negative regulation of sister chromatid segregation (GO:0033046)2.95924498
172negative regulation of mitotic sister chromatid separation (GO:2000816)2.95924498
173regulation of double-strand break repair (GO:2000779)2.94345608
174snRNA processing (GO:0016180)2.93596748
175chromosome organization (GO:0051276)2.93118693
176regulation of RNA export from nucleus (GO:0046831)2.92672727
177kinetochore organization (GO:0051383)2.88961385
178regulation of chromosome segregation (GO:0051983)2.87064117
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86834113
180inner cell mass cell proliferation (GO:0001833)2.84351328
181regulation of gene silencing by RNA (GO:0060966)2.83986436
182regulation of posttranscriptional gene silencing (GO:0060147)2.83986436
183regulation of gene silencing by miRNA (GO:0060964)2.83986436
184* gamete generation (GO:0007276)2.83271311
185DNA packaging (GO:0006323)2.82723683
186regulation of gene expression, epigenetic (GO:0040029)2.80356268
187mitotic G1 DNA damage checkpoint (GO:0031571)2.79627552
188mitotic sister chromatid cohesion (GO:0007064)2.79508108
189spindle checkpoint (GO:0031577)2.76888902
190pre-miRNA processing (GO:0031054)2.74932409
191regulation of protein polyubiquitination (GO:1902914)2.74621674
192histone H3-K9 modification (GO:0061647)2.74096108
193regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73990919
194piRNA metabolic process (GO:0034587)16.6977333
195DNA methylation involved in gamete generation (GO:0043046)13.5083825
196regulation of meiosis I (GO:0060631)13.3475872
197synaptonemal complex assembly (GO:0007130)11.1311889
198synaptonemal complex organization (GO:0070193)10.1574757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.47985645
2EZH2_22144423_ChIP-Seq_EOC_Human6.18474080
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.30327661
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.57947347
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.92850717
6HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.69882603
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.63394692
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.63394692
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.63394692
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.47899985
11REST_21632747_ChIP-Seq_MESCs_Mouse3.46372720
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.34606617
13RARB_27405468_Chip-Seq_BRAIN_Mouse3.33363016
14STAT6_21828071_ChIP-Seq_BEAS2B_Human3.29084498
15JARID2_20064375_ChIP-Seq_MESCs_Mouse3.26030443
16JARID2_20075857_ChIP-Seq_MESCs_Mouse3.09265957
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07552215
18DROSHA_22980978_ChIP-Seq_HELA_Human3.06932571
19AR_21909140_ChIP-Seq_LNCAP_Human3.03734434
20E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02797687
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.00654723
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse3.00612682
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.98124449
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.91081409
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.89147923
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87486384
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87486384
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.79799675
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.77389398
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70644283
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.70392686
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.69706878
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.69474219
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69132877
35EGR1_19374776_ChIP-ChIP_THP-1_Human2.66224770
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61987577
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.55444322
38MYCN_18555785_ChIP-Seq_MESCs_Mouse2.54884964
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49652591
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47591778
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44453291
42EED_16625203_ChIP-ChIP_MESCs_Mouse2.30234379
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29585915
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25955509
45NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23953145
46ZFX_18555785_ChIP-Seq_MESCs_Mouse2.11880795
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.11112777
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.08320751
49SALL1_21062744_ChIP-ChIP_HESCs_Human2.02322537
50RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01862964
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99943314
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99942413
53RNF2_27304074_Chip-Seq_NSC_Mouse1.89568182
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86648537
55KDM5A_27292631_Chip-Seq_BREAST_Human1.82613472
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77056546
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75458092
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.71583289
59KDM2B_26808549_Chip-Seq_K562_Human1.66459640
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63115528
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60993198
62RUNX1_26923725_Chip-Seq_HPCs_Mouse1.59474617
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57947530
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56677755
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55671463
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55260517
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53570175
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52587164
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.50949493
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46452333
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.45470718
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45153467
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44861368
74CTCF_27219007_Chip-Seq_Bcells_Human1.43981752
75XRN2_22483619_ChIP-Seq_HELA_Human1.43287891
76ZNF263_19887448_ChIP-Seq_K562_Human1.42976487
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42482455
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38894341
79DCP1A_22483619_ChIP-Seq_HELA_Human1.38335056
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37957640
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34228237
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33108355
83GBX2_23144817_ChIP-Seq_PC3_Human1.32684327
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28380536
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.28227699
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25427200
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25106989
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23834340
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23402593
90OCT4_19829295_ChIP-Seq_ESCs_Human1.22749395
91* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22251031
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20684114
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19013473
94GATA1_22025678_ChIP-Seq_K562_Human1.18711589
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18413132
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16650193
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14750771
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12823546
99CHD1_26751641_Chip-Seq_LNCaP_Human1.12675696
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.11017848
101GABP_19822575_ChIP-Seq_HepG2_Human1.10814840
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10802003
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08589705
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07338812
105* SMC4_20622854_ChIP-Seq_HELA_Human1.07093854
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06849914
107AR_21572438_ChIP-Seq_LNCaP_Human1.05000322
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03156806
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02979320
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.02697572
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02369922
112KLF4_19829295_ChIP-Seq_ESCs_Human1.02025939
113TCF7_22412390_ChIP-Seq_EML_Mouse1.00955733
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00399840
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99890774
116REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99325987
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98996621
118AR_19668381_ChIP-Seq_PC3_Human0.98714966
119* LXR_22292898_ChIP-Seq_THP-1_Human0.98544682
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.98295582
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97443978
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96802861
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.96416169
124* P68_20966046_ChIP-Seq_HELA_Human0.95812982
125MYC_18940864_ChIP-ChIP_HL60_Human0.95611333
126TTF2_22483619_ChIP-Seq_HELA_Human0.95413233
127MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94638373
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93708229
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93263378
130DPY_21335234_ChIP-Seq_ESCs_Mouse0.89543573
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87867070
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87604108
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87093971
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86903051
135FUS_26573619_Chip-Seq_HEK293_Human0.86498929
136GABP_17652178_ChIP-ChIP_JURKAT_Human0.86428571
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84859724
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84859724
139VDR_23849224_ChIP-Seq_CD4+_Human0.84372087
140HOXB7_26014856_ChIP-Seq_BT474_Human0.83442586
141TFEB_21752829_ChIP-Seq_HELA_Human0.83323315
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83267678
143ETS1_20019798_ChIP-Seq_JURKAT_Human0.83024155
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83009227
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82525582
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82304807
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.81324888
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80487641
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80101272
150ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79991889
151THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79890698
152CLOCK_20551151_ChIP-Seq_293T_Human0.79234681
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79000480
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78801775
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78433124
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77737694
157CIITA_25753668_ChIP-Seq_RAJI_Human0.77541966
158* SOX2_21211035_ChIP-Seq_LN229_Gbm0.77512623
159SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77285799
160CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77152855
161EGR1_19032775_ChIP-ChIP_M12_Human0.76880487
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76708400
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76608173
164CREB1_26743006_Chip-Seq_LNCaP_Human0.76555209
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76402067
166KDM2B_26808549_Chip-Seq_DND41_Human0.76373227
167SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.76357140
168TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.76183572
169CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76039096
170SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.75309697
171RUNX1_27514584_Chip-Seq_MCF-7_Human0.75231820
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74220590
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74169529
174TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73598641
175RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73558426
176MYC_19915707_ChIP-ChIP_AK7_Human0.73490885
177MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73150175
178HTT_18923047_ChIP-ChIP_STHdh_Human0.72642146
179ATF3_27146783_Chip-Seq_COLON_Human0.72395947
180GATA3_21867929_ChIP-Seq_TH1_Mouse0.72294333
181SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.72210342
182TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72118825
183ETV1_20927104_ChIP-Seq_GIST48_Human0.69600755
184MYC_27129775_Chip-Seq_CORNEA_Mouse0.68347088
185NOTCH1_21737748_ChIP-Seq_TLL_Human0.67980907
186* TET1_21451524_ChIP-Seq_MESCs_Mouse0.67953389
187IGF1R_20145208_ChIP-Seq_DFB_Human0.67759625
188TAF15_26573619_Chip-Seq_HEK293_Human0.67270292
189SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.67137277
190CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.66963831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.21556109
2MP0004859_abnormal_synaptic_plasticity7.19821810
3MP0003880_abnormal_central_pattern5.84329191
4MP0004270_analgesia4.31861223
5MP0002009_preneoplasia4.26597829
6MP0003635_abnormal_synaptic_transmissio4.21319732
7* MP0002210_abnormal_sex_determination3.99851946
8MP0002064_seizures3.87873508
9MP0003786_premature_aging3.87724470
10MP0000537_abnormal_urethra_morphology3.64848589
11MP0009745_abnormal_behavioral_response3.54151645
12MP0005423_abnormal_somatic_nervous3.43191809
13* MP0001929_abnormal_gametogenesis3.32927814
14MP0002063_abnormal_learning/memory/cond3.28999086
15* MP0001145_abnormal_male_reproductive3.28562558
16MP0002272_abnormal_nervous_system3.10741580
17MP0001486_abnormal_startle_reflex3.04848676
18MP0003123_paternal_imprinting3.04435866
19MP0001968_abnormal_touch/_nociception3.03694921
20MP0002734_abnormal_mechanical_nocicepti2.92168855
21* MP0000653_abnormal_sex_gland2.87338213
22MP0009046_muscle_twitch2.78675552
23MP0002572_abnormal_emotion/affect_behav2.70353315
24MP0003698_abnormal_male_reproductive2.63747655
25MP0003315_abnormal_perineum_morphology2.57799815
26MP0010094_abnormal_chromosome_stability2.57658208
27MP0002736_abnormal_nociception_after2.43274492
28MP0001501_abnormal_sleep_pattern2.39565103
29MP0008058_abnormal_DNA_repair2.38544653
30MP0008569_lethality_at_weaning2.27476336
31MP0003111_abnormal_nucleus_morphology2.24348323
32MP0003329_amyloid_beta_deposits2.22257475
33MP0008057_abnormal_DNA_replication2.16943625
34MP0002735_abnormal_chemical_nociception2.07471264
35MP0008877_abnormal_DNA_methylation10.6686958
36MP0001970_abnormal_pain_threshold1.92947708
37MP0004957_abnormal_blastocyst_morpholog1.89330260
38MP0003878_abnormal_ear_physiology1.87756722
39MP0005377_hearing/vestibular/ear_phenot1.87756722
40MP0002733_abnormal_thermal_nociception1.83621724
41MP0003077_abnormal_cell_cycle1.79059242
42MP0002067_abnormal_sensory_capabilities1.78070986
43MP0003121_genomic_imprinting1.76138026
44MP0004811_abnormal_neuron_physiology1.75626121
45MP0003690_abnormal_glial_cell1.73309891
46MP0005646_abnormal_pituitary_gland1.70062065
47MP0004145_abnormal_muscle_electrophysio1.69328190
48MP0002166_altered_tumor_susceptibility1.69170171
49MP0009780_abnormal_chondrocyte_physiolo1.67278040
50MP0000920_abnormal_myelination1.60800973
51MP0003633_abnormal_nervous_system1.59959891
52MP0002557_abnormal_social/conspecific_i1.58249951
53MP0001440_abnormal_grooming_behavior1.55685893
54MP0004885_abnormal_endolymph1.51339433
55MP0001502_abnormal_circadian_rhythm1.51204119
56MP0002066_abnormal_motor_capabilities/c1.50634212
57MP0003787_abnormal_imprinting1.48274476
58MP0002161_abnormal_fertility/fecundity1.48049911
59MP0005647_abnormal_sex_gland1.46074277
60MP0002006_tumorigenesis1.45321262
61MP0002882_abnormal_neuron_morphology1.43264394
62MP0001119_abnormal_female_reproductive1.42804037
63MP0006276_abnormal_autonomic_nervous1.42667909
64MP0003693_abnormal_embryo_hatching1.41426326
65MP0010307_abnormal_tumor_latency1.39426224
66MP0001730_embryonic_growth_arrest1.36830457
67MP0000778_abnormal_nervous_system1.34037869
68MP0001177_atelectasis1.34009994
69MP0005623_abnormal_meninges_morphology1.32947336
70MP0003631_nervous_system_phenotype1.29648758
71MP0000955_abnormal_spinal_cord1.28785257
72MP0008007_abnormal_cellular_replicative1.25084821
73MP0001905_abnormal_dopamine_level1.21537127
74MP0004924_abnormal_behavior1.21448423
75MP0005386_behavior/neurological_phenoty1.21448423
76MP0004808_abnormal_hematopoietic_stem1.21405489
77MP0002229_neurodegeneration1.20225845
78MP0003936_abnormal_reproductive_system1.18444510
79MP0004742_abnormal_vestibular_system1.15693801
80MP0005551_abnormal_eye_electrophysiolog1.15465559
81MP0001963_abnormal_hearing_physiology1.14397045
82MP0005076_abnormal_cell_differentiation1.12813005
83MP0002184_abnormal_innervation1.10835288
84MP0001346_abnormal_lacrimal_gland1.10768406
85MP0002160_abnormal_reproductive_system1.10447436
86MP0004036_abnormal_muscle_relaxation1.09861284
87MP0004147_increased_porphyrin_level1.07349769
88MP0001984_abnormal_olfaction1.06986242
89MP0003075_altered_response_to1.04161339
90MP0003890_abnormal_embryonic-extraembry1.03668554
91MP0002822_catalepsy1.03113887
92MP0000350_abnormal_cell_proliferation1.02754176
93MP0000604_amyloidosis1.02180305
94MP0001661_extended_life_span1.02036593
95MP0010352_gastrointestinal_tract_polyps1.01693569
96MP0002152_abnormal_brain_morphology0.99633768
97MP0003699_abnormal_female_reproductive0.96848905
98MP0001485_abnormal_pinna_reflex0.96495309
99MP0008932_abnormal_embryonic_tissue0.95113836
100MP0003634_abnormal_glial_cell0.94689379
101MP0004185_abnormal_adipocyte_glucose0.94533527
102MP0004197_abnormal_fetal_growth/weight/0.94350518
103MP0010386_abnormal_urinary_bladder0.93412283
104MP0008874_decreased_physiological_sensi0.93330782
105MP0003122_maternal_imprinting0.87466889
106MP0003183_abnormal_peptide_metabolism0.87422470
107MP0001986_abnormal_taste_sensitivity0.84182482
108MP0010234_abnormal_vibrissa_follicle0.83999337
109MP0002085_abnormal_embryonic_tissue0.83154143
110MP0005167_abnormal_blood-brain_barrier0.80478853
111MP0001915_intracranial_hemorrhage0.79120482
112MP0000569_abnormal_digit_pigmentation0.79044230
113MP0000538_abnormal_urinary_bladder0.77944017
114MP0000427_abnormal_hair_cycle0.77038856
115MP0001919_abnormal_reproductive_system0.75938162
116MP0001697_abnormal_embryo_size0.75294600
117MP0002084_abnormal_developmental_patter0.74889568
118MP0001672_abnormal_embryogenesis/_devel0.74742631
119MP0005380_embryogenesis_phenotype0.74742631
120MP0005410_abnormal_fertilization0.73404682
121MP0009672_abnormal_birth_weight0.72691618
122MP0003172_abnormal_lysosome_physiology0.70730676
123MP0002638_abnormal_pupillary_reflex0.70628329
124MP0002019_abnormal_tumor_incidence0.70002813
125MP0005535_abnormal_body_temperature0.69679350
126MP0003984_embryonic_growth_retardation0.68548383
127MP0002752_abnormal_somatic_nervous0.68354613
128MP0003646_muscle_fatigue0.67517093
129MP0002069_abnormal_eating/drinking_beha0.65939992
130MP0003938_abnormal_ear_development0.65541353
131MP0001727_abnormal_embryo_implantation0.64522540
132MP0008872_abnormal_physiological_respon0.64418413
133MP0002088_abnormal_embryonic_growth/wei0.64175632
134MP0005645_abnormal_hypothalamus_physiol0.62496398
135MP0004233_abnormal_muscle_weight0.61653059
136MP0002102_abnormal_ear_morphology0.61540138
137MP0003937_abnormal_limbs/digits/tail_de0.61145553
138MP0003115_abnormal_respiratory_system0.60636496
139MP0005389_reproductive_system_phenotype0.60085019
140MP0001188_hyperpigmentation0.59820146
141MP0000026_abnormal_inner_ear0.59683753
142MP0002080_prenatal_lethality0.58687064
143MP0003879_abnormal_hair_cell0.58329805
144MP0000313_abnormal_cell_death0.57934027
145MP0003718_maternal_effect0.57757090
146MP0002086_abnormal_extraembryonic_tissu0.57578733
147MP0003283_abnormal_digestive_organ0.56655222
148MP0000747_muscle_weakness0.56006435
149MP0004130_abnormal_muscle_cell0.54865739
150MP0006072_abnormal_retinal_apoptosis0.54758360
151MP0005166_decreased_susceptibility_to0.54089880
152MP0009278_abnormal_bone_marrow0.53471720
153MP0010678_abnormal_skin_adnexa0.52951322
154MP0003221_abnormal_cardiomyocyte_apopto0.51377936
155MP0005248_abnormal_Harderian_gland0.50253115
156MP0002873_normal_phenotype0.49856411
157MP0002169_no_abnormal_phenotype0.48122267
158MP0003956_abnormal_body_size0.47493037
159MP0009703_decreased_birth_body0.47282190
160MP0000631_abnormal_neuroendocrine_gland0.47020815
161MP0003705_abnormal_hypodermis_morpholog0.46849461
162MP0002139_abnormal_hepatobiliary_system0.46799713
163MP0003195_calcinosis0.46766042
164MP0003137_abnormal_impulse_conducting0.46316274
165MP0002697_abnormal_eye_size0.46067996
166MP0000751_myopathy0.45976564
167MP0003567_abnormal_fetal_cardiomyocyte0.45965979
168MP0000383_abnormal_hair_follicle0.45108080
169MP0010769_abnormal_survival0.44965413
170MP0001943_abnormal_respiration0.44608968
171MP0004043_abnormal_pH_regulation0.44520036
172MP0005395_other_phenotype0.43969759
173MP0000639_abnormal_adrenal_gland0.43628777
174MP0005171_absent_coat_pigmentation0.43442248
175MP0003045_fibrosis0.43267985
176MP0000579_abnormal_nail_morphology0.43014221
177MP0006292_abnormal_olfactory_placode0.42711186
178MP0000428_abnormal_craniofacial_morphol0.41406136
179MP0003119_abnormal_digestive_system0.40846912
180MP0005408_hypopigmentation0.40412428
181MP0003632_abnormal_nervous_system0.38821407
182MP0005621_abnormal_cell_physiology0.38555085
183MP0004084_abnormal_cardiac_muscle0.38066258
184MP0003861_abnormal_nervous_system0.38038599
185MP0000534_abnormal_ureter_morphology0.37447313
186MP0005666_abnormal_adipose_tissue0.37388128
187MP0003942_abnormal_urinary_system0.37200809

Predicted human phenotypes

RankGene SetZ-score
1Abnormal spermatogenesis (HP:0008669)9.89812835
2Gonadotropin excess (HP:0000837)9.66976340
3Myokymia (HP:0002411)8.12177604
4Focal motor seizures (HP:0011153)6.98622678
5Focal seizures (HP:0007359)6.25796401
6Action tremor (HP:0002345)5.87116276
7Prostate neoplasm (HP:0100787)5.80857660
8Atonic seizures (HP:0010819)5.63279193
9Febrile seizures (HP:0002373)5.54592013
10Testicular atrophy (HP:0000029)5.29581917
11Epileptic encephalopathy (HP:0200134)5.20378301
12Supranuclear gaze palsy (HP:0000605)4.89796536
13Male pseudohermaphroditism (HP:0000037)4.72033326
14Ankle clonus (HP:0011448)4.68227818
15Diplopia (HP:0000651)4.65406231
16Abnormality of binocular vision (HP:0011514)4.65406231
17Testicular neoplasm (HP:0010788)4.50787224
18Male infertility (HP:0003251)4.50697444
19Visual hallucinations (HP:0002367)4.36659445
20Impaired vibration sensation in the lower limbs (HP:0002166)4.25014657
21Spastic gait (HP:0002064)4.24978711
22Urinary bladder sphincter dysfunction (HP:0002839)4.17308761
23Abnormality of the lower motor neuron (HP:0002366)4.13399798
24Gonadal dysgenesis (HP:0000133)4.07637481
2511 pairs of ribs (HP:0000878)4.07250887
26Annular pancreas (HP:0001734)4.01508599
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.91991870
28Degeneration of the lateral corticospinal tracts (HP:0002314)3.91991870
29Abnormality of male internal genitalia (HP:0000022)3.91074041
30Facial hemangioma (HP:0000329)3.83409531
31Neurofibrillary tangles (HP:0002185)3.82846949
32Generalized tonic-clonic seizures (HP:0002069)3.82211474
33Abnormality of the corticospinal tract (HP:0002492)3.69576058
34Hand muscle atrophy (HP:0009130)3.63726534
35Abnormal eating behavior (HP:0100738)3.60023959
36Urinary urgency (HP:0000012)3.58654103
37Absence seizures (HP:0002121)3.56749710
38Torticollis (HP:0000473)3.54970942
39Progressive cerebellar ataxia (HP:0002073)3.52628153
40Dysmetria (HP:0001310)3.37192433
41Tetraplegia (HP:0002445)3.36433203
42Delusions (HP:0000746)3.35089972
43Postural instability (HP:0002172)3.33171306
44Dialeptic seizures (HP:0011146)3.26852782
45Papilledema (HP:0001085)3.26748580
46Status epilepticus (HP:0002133)3.25855419
47Poor eye contact (HP:0000817)3.25220301
48Metaphyseal cupping (HP:0003021)3.22568609
49Intention tremor (HP:0002080)3.22432211
50Truncal ataxia (HP:0002078)3.18164293
51Papillary thyroid carcinoma (HP:0002895)3.15983795
52Neuronal loss in central nervous system (HP:0002529)3.08183296
53Calf muscle hypertrophy (HP:0008981)3.06135472
54Cerebral hypomyelination (HP:0006808)3.02868560
55Impaired vibratory sensation (HP:0002495)3.00988075
56Focal dystonia (HP:0004373)3.00523304
57Limb dystonia (HP:0002451)2.99374706
58Obstructive sleep apnea (HP:0002870)2.98706972
59Amblyopia (HP:0000646)2.96303742
60Depression (HP:0000716)2.96090089
61Infertility (HP:0000789)2.93305623
62Cerebral inclusion bodies (HP:0100314)2.92587855
63Anxiety (HP:0000739)2.92450101
64Chromsome breakage (HP:0040012)2.92108854
65Lower limb muscle weakness (HP:0007340)2.88432128
66Distal upper limb amyotrophy (HP:0007149)2.86891329
67Upper limb amyotrophy (HP:0009129)2.86891329
68Clonus (HP:0002169)2.85748558
69Mutism (HP:0002300)2.77393424
70Apathy (HP:0000741)2.75034078
71Bradykinesia (HP:0002067)2.74748790
72Craniofacial dystonia (HP:0012179)2.73581760
73Duplicated collecting system (HP:0000081)2.73205324
74Capillary hemangiomas (HP:0005306)2.72575947
75Hemiplegia (HP:0002301)2.72084555
76Abnormal sex determination (HP:0012244)2.71594585
77Sex reversal (HP:0012245)2.71594585
78Muscle hypertrophy of the lower extremities (HP:0008968)2.70017829
79Peripheral hypomyelination (HP:0007182)2.69539233
80Epileptiform EEG discharges (HP:0011182)2.68254494
81Ankle contracture (HP:0006466)2.63530242
82Bundle branch block (HP:0011710)2.60155103
83Abnormality of the axillary hair (HP:0100134)2.59566108
84Abnormality of secondary sexual hair (HP:0009888)2.59566108
85Hypoplasia of the uterus (HP:0000013)2.59059887
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54001916
87Abnormality of the fingertips (HP:0001211)2.52330614
88Shoulder girdle muscle weakness (HP:0003547)2.51546335
89Abnormal social behavior (HP:0012433)2.51435417
90Impaired social interactions (HP:0000735)2.51435417
91Impaired smooth pursuit (HP:0007772)2.50572391
92Ventricular fibrillation (HP:0001663)2.48672498
93Diminished motivation (HP:0000745)2.48054460
94Abnormality of the aortic arch (HP:0012303)2.44790115
95Spontaneous abortion (HP:0005268)2.42707692
96Akinesia (HP:0002304)2.41678354
97Dysdiadochokinesis (HP:0002075)2.41426302
98Ectopic kidney (HP:0000086)2.39868358
99Overriding aorta (HP:0002623)2.39416486
100Missing ribs (HP:0000921)2.38440199
101Spastic tetraparesis (HP:0001285)2.37507582
102Hemiparesis (HP:0001269)2.35537355
103Abnormality of the renal collecting system (HP:0004742)2.29620781
104Dysphonia (HP:0001618)2.29223197
105Abnormality of saccadic eye movements (HP:0000570)2.28455913
106Morphological abnormality of the pyramidal tract (HP:0002062)2.27830394
107Abnormality of ocular smooth pursuit (HP:0000617)2.27543134
108Primary amenorrhea (HP:0000786)2.27363550
109Fibular hypoplasia (HP:0003038)2.27183096
110Abnormality of the musculature of the hand (HP:0001421)2.26720544
111Spinal canal stenosis (HP:0003416)2.25468689
112Sleep apnea (HP:0010535)2.24984847
113EEG with generalized epileptiform discharges (HP:0011198)2.22930519
114Rectal prolapse (HP:0002035)2.20054816
115Limb-girdle muscle weakness (HP:0003325)2.19759953
116Stereotypic behavior (HP:0000733)2.19099983
117Colon cancer (HP:0003003)2.18580235
118Abnormality of the labia minora (HP:0012880)2.18472109
119Pelvic girdle muscle weakness (HP:0003749)2.17039603
120Choreoathetosis (HP:0001266)2.15571985
121Rigidity (HP:0002063)2.14809308
122Amyotrophic lateral sclerosis (HP:0007354)2.14084631
123Gaze-evoked nystagmus (HP:0000640)2.13046286
124Aplasia/hypoplasia of the uterus (HP:0008684)2.10366413
125Renovascular hypertension (HP:0100817)2.09333741
126Incomplete penetrance (HP:0003829)2.08638616
127Germ cell neoplasia (HP:0100728)2.08137330
128Fasciculations (HP:0002380)2.06891123
129Oligodactyly (hands) (HP:0001180)2.06707757
130Astrocytoma (HP:0009592)2.05191451
131Abnormality of the astrocytes (HP:0100707)2.05191451
132Abnormality of the prostate (HP:0008775)2.04643264
133Hypsarrhythmia (HP:0002521)2.03473701
134Bulbar palsy (HP:0001283)2.02545290
135Slow saccadic eye movements (HP:0000514)2.02350468
136Heart block (HP:0012722)2.00333756
137Azoospermia (HP:0000027)12.0533423
138Insomnia (HP:0100785)1.99345246
139Increased nuchal translucency (HP:0010880)1.98840459
140Absent thumb (HP:0009777)1.98337813
141Oligodactyly (HP:0012165)1.95667069
142Hypoplastic iliac wings (HP:0002866)1.95282971
143Scanning speech (HP:0002168)1.95261402
144Abnormality of the periventricular white matter (HP:0002518)1.92643396
145Overlapping toe (HP:0001845)1.92035798
146Hyperpituitarism (HP:0010514)1.91615488
147Dementia (HP:0000726)1.91602244
148Sandal gap (HP:0001852)1.91211824
149Narrow palate (HP:0000189)1.90909238
150Lower limb asymmetry (HP:0100559)1.89936569
151Cutaneous melanoma (HP:0012056)1.88606180
152Increased circulating renin level (HP:0000848)1.88528690
153Heterotopia (HP:0002282)1.88402113
154Premature ovarian failure (HP:0008209)1.88325180
155Secondary amenorrhea (HP:0000869)1.86969418
156Memory impairment (HP:0002354)1.86700965
157Ureteral duplication (HP:0000073)1.85891122
158Impulsivity (HP:0100710)1.85857587
159Absent hair (HP:0002298)1.85216975
160CNS hypomyelination (HP:0003429)1.85147016
161Megalencephaly (HP:0001355)1.83779796
162Congenital stationary night blindness (HP:0007642)1.83659217
163Abnormality of the hip-girdle musculature (HP:0001445)1.82395993
164Abnormality of the musculature of the pelvis (HP:0001469)1.82395993
165Glioma (HP:0009733)1.82185525
166Abnormality of the calcaneus (HP:0008364)1.81787994
167Rimmed vacuoles (HP:0003805)1.81753639
168Spinal muscular atrophy (HP:0007269)1.80283276
169Bronchomalacia (HP:0002780)1.79665736
170Breast hypoplasia (HP:0003187)1.78809946
171Gait ataxia (HP:0002066)1.78646229
172Thyroid carcinoma (HP:0002890)1.77722214
173Rhabdomyosarcoma (HP:0002859)1.77715775
174Proximal placement of thumb (HP:0009623)1.76319389
175Abnormal atrioventricular conduction (HP:0005150)1.75717075
176Upper motor neuron abnormality (HP:0002127)1.74937952
177Female pseudohermaphroditism (HP:0010458)1.74804927
178Abnormality of chromosome stability (HP:0003220)1.74592783
179Split foot (HP:0001839)1.74269057
180Aplasia of the phalanges of the hand (HP:0009802)1.74017638
181Aplasia involving bones of the extremities (HP:0009825)1.74017638
182Aplasia involving bones of the upper limbs (HP:0009823)1.74017638
183Ependymoma (HP:0002888)1.71253058
184Thin ribs (HP:0000883)1.71006786
185Tongue fasciculations (HP:0001308)1.70323421
186Short 4th metacarpal (HP:0010044)1.69594060
187Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69594060
188Relative macrocephaly (HP:0004482)1.68708298
189Long eyelashes (HP:0000527)1.66929147
190Aplasia/Hypoplasia of the fibula (HP:0006492)1.65656414
191Hyperacusis (HP:0010780)1.64507616
192Polycystic ovaries (HP:0000147)1.64423054
193Gynecomastia (HP:0000771)1.63772689
194Neoplasm of striated muscle (HP:0009728)1.63671487
195Abnormal lung lobation (HP:0002101)1.61942722
196Muscle fibrillation (HP:0010546)1.61302332
197Low anterior hairline (HP:0000294)1.59904388
198Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59677892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.48536533
2CDK126.07169192
3ACVR1B5.51697660
4TNK24.91514137
5CDC74.81277692
6PAK64.04005893
7DAPK24.03783835
8NTRK33.75956055
9TESK23.56357109
10UHMK12.79648041
11PRKD32.74412714
12BRD42.64980887
13CAMKK12.51569907
14CDK72.45803101
15FER2.44657221
16CDK192.34184680
17MAP3K42.23956458
18MINK12.13190036
19RIPK42.11674022
20NEK22.05767647
21TYRO31.94978793
22GRK51.94667779
23ARAF1.89673700
24NTRK21.85591402
25PNCK1.79477745
26DAPK11.78737740
27EEF2K1.68851333
28PINK11.67312703
29CDK91.61622713
30CAMK11.55353258
31WEE11.52546823
32MAP3K131.47937035
33MAP3K111.47262979
34CDK51.40849371
35PKN21.38437026
36STK38L1.36930270
37PLK11.36727692
38ICK1.29327014
39CHEK11.29310606
40ATR1.27176847
41CDK41.27009919
42CDC42BPA1.24409259
43PRKCG1.24246600
44SCYL21.22528090
45MAP3K61.22113617
46CAMK2B1.20233151
47MELK1.18976953
48LATS11.18163887
49PDK31.16018985
50PDK41.16018985
51KSR21.15948542
52STK381.15642921
53PRPF4B1.15202346
54SIK21.14492925
55ATM1.11653526
56RIPK11.11094232
57CDK81.09887229
58TRIB31.08400809
59MAP3K21.07478086
60BRSK21.07246735
61MKNK21.07243970
62NEK61.07182314
63PAK31.06585392
64CDK151.05622744
65MARK21.03469865
66SGK2231.02110845
67SGK4941.02110845
68TTK1.01818964
69CDK11A1.01616908
70STK31.00664546
71CDK181.00473462
72MTOR1.00144411
73PRKCH0.99876030
74GRK10.98669216
75WNK30.96854057
76BRAF0.96596756
77BMPR20.96501714
78CAMK2A0.96452311
79OXSR10.94160574
80CHEK20.92053633
81CDK140.91216075
82TGFBR10.88187554
83MAP3K90.87884949
84CAMK2G0.87343727
85STK110.82778908
86BRSK10.80845491
87KSR10.80839947
88CASK0.80434975
89MET0.80383299
90CAMK1G0.79324260
91AURKA0.79025738
92PDGFRA0.78351998
93CSNK1A1L0.77317513
94MAPK120.75732900
95SGK10.75063868
96DYRK30.73030603
97PDK10.72272306
98DYRK1A0.71866015
99CDK10.71273101
100CDK20.71161203
101LATS20.67059492
102WNK10.66585171
103PDPK10.66136173
104PLK20.65589711
105CAMK1D0.65583374
106MAPK100.65467165
107PDK20.64878461
108DAPK30.64574351
109PHKG20.64564072
110PHKG10.64564072
111CAMK40.64427337
112PBK0.63988416
113LMTK20.63463968
114RET0.62593193
115PLK40.60659611
116SGK20.60386878
117CSNK1G10.59914693
118STK240.59837146
119NTRK10.59788448
120AURKB0.59504771
121PKN10.59079440
122MKNK10.58302247
123PASK0.58249326
124PTK60.57322282
125PAK40.56485806
126CCNB10.56163035
127FLT30.54604769
128RPS6KA30.52284057
129CAMKK20.51283108
130PRKDC0.50938019
131PLK30.50937431
132LIMK10.49824739
133MAP2K40.49408298
134MAP3K120.49231332
135PRKCZ0.48093228
136CAMK2D0.46253871
137CSNK1G20.44787779
138SGK30.44537157
139BMPR1B0.44505013
140NEK10.43499608
141CSNK1G30.43310779
142MAPK80.42830284
143MAP3K100.42149662
144GSK3B0.41410465
145RPS6KB10.40357892
146PRKG20.40254711
147CSNK1E0.38848472
148MAPK140.37192348
149MAP3K10.37015562
150PTK2B0.35594089
151RAF10.34959208
152PRKCA0.34913422
153MARK30.34785863
154SRPK10.33872383
155PDGFRB0.33696154
156AKT10.33560657
157FYN0.33222141
158CDK60.33031967
159IRAK20.29941314
160CSNK1D0.29064732
161MOS0.28847420
162MAP2K60.28305003
163RPS6KB20.28220982
164STK40.27831242
165ALK0.27656262
166MAPK130.27211307
167FES0.26334155
168MAP3K30.25960399
169PRKACA0.24498853
170MAP2K20.24355979
171PRKG10.23720312
172MARK10.22565221
173PTK20.22281149
174PRKCB0.20925698
175ROCK10.20593525
176TESK10.20457353
177BMX0.20348328
178ERBB20.20084442

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.59206279
2Basal transcription factors_Homo sapiens_hsa030225.16511538
3Synaptic vesicle cycle_Homo sapiens_hsa047214.41889167
4Nicotine addiction_Homo sapiens_hsa050334.38394894
5Cell cycle_Homo sapiens_hsa041103.24754217
6RNA transport_Homo sapiens_hsa030133.20970799
7mRNA surveillance pathway_Homo sapiens_hsa030153.07843271
8RNA polymerase_Homo sapiens_hsa030203.03266619
9Dorso-ventral axis formation_Homo sapiens_hsa043202.98083851
10Homologous recombination_Homo sapiens_hsa034402.96833348
11Amphetamine addiction_Homo sapiens_hsa050312.91321601
12Circadian entrainment_Homo sapiens_hsa047132.81388800
13Morphine addiction_Homo sapiens_hsa050322.79041074
14Insulin secretion_Homo sapiens_hsa049112.75229923
15GABAergic synapse_Homo sapiens_hsa047272.74783261
16DNA replication_Homo sapiens_hsa030302.71006198
17Mismatch repair_Homo sapiens_hsa034302.64379663
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58467787
19Glutamatergic synapse_Homo sapiens_hsa047242.56756438
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42276462
21Oocyte meiosis_Homo sapiens_hsa041142.27241811
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.21334644
23Gastric acid secretion_Homo sapiens_hsa049712.19373300
24Dopaminergic synapse_Homo sapiens_hsa047282.18741025
25Nucleotide excision repair_Homo sapiens_hsa034202.16324473
26Aldosterone synthesis and secretion_Homo sapiens_hsa049252.09206773
27Spliceosome_Homo sapiens_hsa030401.99643070
28Lysine degradation_Homo sapiens_hsa003101.95817536
29Fanconi anemia pathway_Homo sapiens_hsa034601.92941651
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91562638
31Salivary secretion_Homo sapiens_hsa049701.90901966
32Cocaine addiction_Homo sapiens_hsa050301.90889618
33Cholinergic synapse_Homo sapiens_hsa047251.88650532
34Vitamin B6 metabolism_Homo sapiens_hsa007501.83724070
35Selenocompound metabolism_Homo sapiens_hsa004501.81578195
36Calcium signaling pathway_Homo sapiens_hsa040201.80731313
37Oxytocin signaling pathway_Homo sapiens_hsa049211.79723351
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70423828
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69465691
40RNA degradation_Homo sapiens_hsa030181.68381746
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.65662008
42Non-homologous end-joining_Homo sapiens_hsa034501.63022244
43One carbon pool by folate_Homo sapiens_hsa006701.61263956
44TGF-beta signaling pathway_Homo sapiens_hsa043501.52805957
45Base excision repair_Homo sapiens_hsa034101.51144452
46Renin secretion_Homo sapiens_hsa049241.47474113
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47430512
48cAMP signaling pathway_Homo sapiens_hsa040241.45455026
49Phototransduction_Homo sapiens_hsa047441.45218516
50Olfactory transduction_Homo sapiens_hsa047401.39740110
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37294494
52GnRH signaling pathway_Homo sapiens_hsa049121.36578636
53Fatty acid biosynthesis_Homo sapiens_hsa000611.30089392
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29757908
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28884077
56Herpes simplex infection_Homo sapiens_hsa051681.27057116
57Proteasome_Homo sapiens_hsa030501.26046528
58Small cell lung cancer_Homo sapiens_hsa052221.21560049
59Taste transduction_Homo sapiens_hsa047421.19800573
60Collecting duct acid secretion_Homo sapiens_hsa049661.19576385
61Thyroid cancer_Homo sapiens_hsa052161.18552237
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17249278
63Long-term depression_Homo sapiens_hsa047301.16042289
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.14456200
65Serotonergic synapse_Homo sapiens_hsa047261.13661675
66Pyrimidine metabolism_Homo sapiens_hsa002401.09043187
67Melanogenesis_Homo sapiens_hsa049161.04905673
68Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03741221
69Epstein-Barr virus infection_Homo sapiens_hsa051691.01403592
70Cardiac muscle contraction_Homo sapiens_hsa042601.00926754
71Prostate cancer_Homo sapiens_hsa052150.99771883
72Pancreatic secretion_Homo sapiens_hsa049720.96138584
73Gap junction_Homo sapiens_hsa045400.94581456
74p53 signaling pathway_Homo sapiens_hsa041150.94049012
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92005401
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90831028
77Hippo signaling pathway_Homo sapiens_hsa043900.89310258
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88092489
79HTLV-I infection_Homo sapiens_hsa051660.87983669
80Linoleic acid metabolism_Homo sapiens_hsa005910.85931430
81MicroRNAs in cancer_Homo sapiens_hsa052060.85399095
82Pancreatic cancer_Homo sapiens_hsa052120.82150494
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80602158
84Notch signaling pathway_Homo sapiens_hsa043300.78394238
85Prion diseases_Homo sapiens_hsa050200.78261865
86Tight junction_Homo sapiens_hsa045300.78004863
87ECM-receptor interaction_Homo sapiens_hsa045120.77484771
88Adherens junction_Homo sapiens_hsa045200.73326603
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.72751673
90MAPK signaling pathway_Homo sapiens_hsa040100.72095978
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70697198
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69892447
93Purine metabolism_Homo sapiens_hsa002300.68971967
94Colorectal cancer_Homo sapiens_hsa052100.68676678
95Vitamin digestion and absorption_Homo sapiens_hsa049770.67959502
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67862714
97Thyroid hormone synthesis_Homo sapiens_hsa049180.67536188
98Endocytosis_Homo sapiens_hsa041440.66525534
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66377357
100Rap1 signaling pathway_Homo sapiens_hsa040150.65510120
101Bile secretion_Homo sapiens_hsa049760.64540280
102Type II diabetes mellitus_Homo sapiens_hsa049300.60610935
103mTOR signaling pathway_Homo sapiens_hsa041500.60500660
104Ras signaling pathway_Homo sapiens_hsa040140.60185286
105Vibrio cholerae infection_Homo sapiens_hsa051100.58119466
106Renal cell carcinoma_Homo sapiens_hsa052110.55799999
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55227612
108Folate biosynthesis_Homo sapiens_hsa007900.54419765
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53663684
110Viral carcinogenesis_Homo sapiens_hsa052030.53326008
111FoxO signaling pathway_Homo sapiens_hsa040680.53154247
112Influenza A_Homo sapiens_hsa051640.52884538
113Histidine metabolism_Homo sapiens_hsa003400.52133785
114Pathways in cancer_Homo sapiens_hsa052000.51622742
115Arginine and proline metabolism_Homo sapiens_hsa003300.51300046
116Hedgehog signaling pathway_Homo sapiens_hsa043400.51220395
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50438631
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50388771
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50160696
120Amoebiasis_Homo sapiens_hsa051460.49611979
121Mineral absorption_Homo sapiens_hsa049780.49116643
122Non-small cell lung cancer_Homo sapiens_hsa052230.48926020
123Glioma_Homo sapiens_hsa052140.48766557
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48345402
125Focal adhesion_Homo sapiens_hsa045100.48307958
126Ether lipid metabolism_Homo sapiens_hsa005650.48306744
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48064602
128Fatty acid metabolism_Homo sapiens_hsa012120.47268683
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46983068
130Glycerolipid metabolism_Homo sapiens_hsa005610.46459864
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.45015073
132Regulation of autophagy_Homo sapiens_hsa041400.42661653
133Dilated cardiomyopathy_Homo sapiens_hsa054140.42298388
134Prolactin signaling pathway_Homo sapiens_hsa049170.41966702
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41922366
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41721607
137Chronic myeloid leukemia_Homo sapiens_hsa052200.41612680
138Wnt signaling pathway_Homo sapiens_hsa043100.40489988
139Fatty acid degradation_Homo sapiens_hsa000710.38407347
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.37764837
141beta-Alanine metabolism_Homo sapiens_hsa004100.36129430
142Axon guidance_Homo sapiens_hsa043600.35986229
143Pentose phosphate pathway_Homo sapiens_hsa000300.35095396
144Endometrial cancer_Homo sapiens_hsa052130.34271082
145Basal cell carcinoma_Homo sapiens_hsa052170.32510335
146Alcoholism_Homo sapiens_hsa050340.32305489
147Alzheimers disease_Homo sapiens_hsa050100.31413354
148Estrogen signaling pathway_Homo sapiens_hsa049150.31322049
149Sulfur relay system_Homo sapiens_hsa041220.31176794
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30113614
151VEGF signaling pathway_Homo sapiens_hsa043700.29990412
152ErbB signaling pathway_Homo sapiens_hsa040120.29167985
153Fat digestion and absorption_Homo sapiens_hsa049750.27925987
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.27706861
155Toxoplasmosis_Homo sapiens_hsa051450.26578935
156Inositol phosphate metabolism_Homo sapiens_hsa005620.25808548
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.24676475
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24225211
159Biosynthesis of amino acids_Homo sapiens_hsa012300.24050988
160Arginine biosynthesis_Homo sapiens_hsa002200.23477912
161Circadian rhythm_Homo sapiens_hsa047100.22500834
162AMPK signaling pathway_Homo sapiens_hsa041520.22099921
163Choline metabolism in cancer_Homo sapiens_hsa052310.21531496
164Insulin signaling pathway_Homo sapiens_hsa049100.21414519
165Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20932526
166Renin-angiotensin system_Homo sapiens_hsa046140.20657810
167Long-term potentiation_Homo sapiens_hsa047200.19189499
168Proteoglycans in cancer_Homo sapiens_hsa052050.18793937
169Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18289801
170Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15867189
171Neurotrophin signaling pathway_Homo sapiens_hsa047220.14685958
172Glucagon signaling pathway_Homo sapiens_hsa049220.14153630
173Antigen processing and presentation_Homo sapiens_hsa046120.13625673
174African trypanosomiasis_Homo sapiens_hsa051430.12696827

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