SORBS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.40715500
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.23557218
3sarcomere organization (GO:0045214)5.03143232
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.85315054
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.76892420
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.72648773
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.59132313
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.58310196
9myofibril assembly (GO:0030239)4.47666233
10negative regulation of potassium ion transmembrane transport (GO:1901380)4.37584271
11cardiac muscle hypertrophy (GO:0003300)4.35341319
12cell communication by electrical coupling (GO:0010644)4.30255404
13cell communication involved in cardiac conduction (GO:0086065)4.17024978
14cardiac muscle contraction (GO:0060048)4.12152440
15striated muscle hypertrophy (GO:0014897)4.11189655
16regulation of sarcomere organization (GO:0060297)4.08127603
17ventricular cardiac muscle cell action potential (GO:0086005)4.03795350
18detection of calcium ion (GO:0005513)3.91366967
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.75418612
20regulation of actin filament-based movement (GO:1903115)3.74934812
21regulation of membrane repolarization (GO:0060306)3.72050574
22cardiac muscle cell development (GO:0055013)3.67853326
23actomyosin structure organization (GO:0031032)3.55562499
24positive regulation of action potential (GO:0045760)3.53432612
25cardiac muscle tissue morphogenesis (GO:0055008)3.53257089
26muscle hypertrophy (GO:0014896)3.52593024
27regulation of cardioblast differentiation (GO:0051890)3.51249227
28cardiac cell development (GO:0055006)3.46990220
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44756943
30actin-myosin filament sliding (GO:0033275)3.44543263
31muscle filament sliding (GO:0030049)3.44543263
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.42786227
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.38537499
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37086814
35relaxation of cardiac muscle (GO:0055119)3.37013912
36cardiac conduction (GO:0061337)3.36409898
37sarcoplasmic reticulum calcium ion transport (GO:0070296)3.35802052
38cardiac muscle hypertrophy in response to stress (GO:0014898)3.34588094
39muscle hypertrophy in response to stress (GO:0003299)3.34588094
40cardiac muscle adaptation (GO:0014887)3.34588094
41adult heart development (GO:0007512)3.34445169
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.31219938
43pyrimidine nucleobase catabolic process (GO:0006208)3.31139899
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.30096653
45plasma membrane repair (GO:0001778)3.30045168
46regulation of cell communication by electrical coupling (GO:0010649)3.29555912
47regulation of striated muscle contraction (GO:0006942)3.25475910
48heart trabecula formation (GO:0060347)3.22489948
49cardiac muscle cell action potential (GO:0086001)3.20673746
50regulation of relaxation of muscle (GO:1901077)3.20624637
51atrial septum morphogenesis (GO:0060413)3.16929564
52regulation of the force of heart contraction (GO:0002026)3.16212519
53regulation of cardiac muscle contraction (GO:0055117)3.16110283
54muscle tissue morphogenesis (GO:0060415)3.15731923
55cardiac chamber formation (GO:0003207)3.14756855
56regulation of heart rate by cardiac conduction (GO:0086091)3.14755208
57actin-mediated cell contraction (GO:0070252)3.11597124
58cardiac muscle cell action potential involved in contraction (GO:0086002)3.08378411
59striated muscle contraction (GO:0006941)3.06330783
60regulation of cardiac muscle cell contraction (GO:0086004)3.06145552
61regulation of ATPase activity (GO:0043462)3.00961405
62regulation of ATP catabolic process (GO:1903289)3.00961405
63regulation of heart rate (GO:0002027)2.98762754
64response to epinephrine (GO:0071871)2.98638697
65positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.95611562
66cellular response to epinephrine stimulus (GO:0071872)2.94165584
67membrane repolarization during action potential (GO:0086011)2.92984657
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90846934
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89738411
70response to inactivity (GO:0014854)2.89199945
71positive regulation of sodium ion transport (GO:0010765)2.88433142
72regulation of skeletal muscle contraction (GO:0014819)2.86542551
73negative regulation of protein localization to cell surface (GO:2000009)2.84799413
74carnitine shuttle (GO:0006853)2.84116742
75positive regulation of heart rate (GO:0010460)2.83165148
76response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77818416
77regulation of calcium ion transmembrane transport (GO:1903169)2.77028852
78regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77028852
79negative regulation of heart rate (GO:0010459)2.76190052
80nucleobase catabolic process (GO:0046113)2.75895827
81regulation of heart contraction (GO:0008016)2.73933076
82negative regulation of potassium ion transport (GO:0043267)2.73125935
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.71956709
84heart process (GO:0003015)2.71466925
85heart contraction (GO:0060047)2.71466925
86tricarboxylic acid cycle (GO:0006099)2.69979263
87positive regulation of heart contraction (GO:0045823)2.68387943
88positive regulation of cardiac muscle hypertrophy (GO:0010613)2.68174609
89positive regulation of muscle hypertrophy (GO:0014742)2.68174609
90positive regulation of cation channel activity (GO:2001259)2.66447892
91regulation of action potential (GO:0098900)2.64344397
92positive regulation of ATPase activity (GO:0032781)2.63386124
93positive regulation of ATP catabolic process (GO:1903291)2.63386124
94striated muscle cell development (GO:0055002)2.61869619
95regulation of potassium ion transmembrane transport (GO:1901379)2.60261106
96response to caffeine (GO:0031000)2.59587836
97axonal fasciculation (GO:0007413)2.59549319
98cardiac muscle tissue development (GO:0048738)2.56961741
99regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56172144
100regulation of potassium ion transmembrane transporter activity (GO:1901016)2.56099133
101neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55711771
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55387583
103cardiac right ventricle morphogenesis (GO:0003215)2.55140590
104adrenergic receptor signaling pathway (GO:0071875)2.54600688
105vocalization behavior (GO:0071625)2.54101901
106cardiac ventricle formation (GO:0003211)2.53694379
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.53672709
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52663954
109dendritic spine morphogenesis (GO:0060997)2.52228673
110multicellular organismal signaling (GO:0035637)2.52007502
111positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51695705
112positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49680115
113relaxation of muscle (GO:0090075)2.49234377
114actin filament-based movement (GO:0030048)2.48755100
115ventricular cardiac muscle cell development (GO:0055015)2.46617057
116regulation of glutamate receptor signaling pathway (GO:1900449)2.46306511
117regulation of voltage-gated calcium channel activity (GO:1901385)2.46003255
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.44025721
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.43504779
120fatty acid transmembrane transport (GO:1902001)2.43484517
121positive regulation of potassium ion transport (GO:0043268)2.42927308
122negative regulation of striated muscle cell apoptotic process (GO:0010664)2.42853249
123venous blood vessel morphogenesis (GO:0048845)2.42280900
124positive regulation of cardiac muscle tissue growth (GO:0055023)2.41077028
125cell junction maintenance (GO:0034331)2.41023245
126membrane repolarization (GO:0086009)2.39859737
127regulation of cation channel activity (GO:2001257)2.38673615
128activation of protein kinase A activity (GO:0034199)2.38185108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54200321
2GBX2_23144817_ChIP-Seq_PC3_Human3.05315531
3* EP300_21415370_ChIP-Seq_HL-1_Mouse2.63313861
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44539110
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34310080
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14165669
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11472835
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11472835
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11252475
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07444114
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06177497
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.05433882
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99939642
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95158532
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.93301969
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93099364
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92272577
18DROSHA_22980978_ChIP-Seq_HELA_Human1.88843642
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87124899
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78553894
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77936615
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.72253578
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.66469564
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65693690
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.64939668
26SMAD4_21799915_ChIP-Seq_A2780_Human1.61919727
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61422216
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.61389432
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57298411
30TAF15_26573619_Chip-Seq_HEK293_Human1.56559060
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54998651
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54590618
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52709307
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52276507
35AR_21572438_ChIP-Seq_LNCaP_Human1.47898602
36AHR_22903824_ChIP-Seq_MCF-7_Human1.46520454
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41794927
38FUS_26573619_Chip-Seq_HEK293_Human1.41344926
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.40309124
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40143305
41REST_21632747_ChIP-Seq_MESCs_Mouse1.39441997
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39238565
43ZNF274_21170338_ChIP-Seq_K562_Hela1.38903887
44* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38274588
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.38056400
46* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37663489
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.37342786
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.37323889
49RNF2_27304074_Chip-Seq_NSC_Mouse1.36732438
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35809571
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35368013
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34717849
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33986769
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32027745
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31921870
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.31803010
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30858132
58BCAT_22108803_ChIP-Seq_LS180_Human1.29452827
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27687169
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27312351
61P300_19829295_ChIP-Seq_ESCs_Human1.25460153
62* STAT3_23295773_ChIP-Seq_U87_Human1.24444102
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.23985132
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.23985132
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23249940
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22345698
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21555953
68TP53_16413492_ChIP-PET_HCT116_Human1.21480176
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21017869
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18638022
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.18474969
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.17996057
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17861693
74* AR_19668381_ChIP-Seq_PC3_Human1.16803492
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16344695
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16122228
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16015445
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15134737
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14504731
80SMAD4_21741376_ChIP-Seq_HESCs_Human1.13910617
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12450013
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.10813759
83AR_25329375_ChIP-Seq_VCAP_Human1.09902215
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.09755443
85TCF4_23295773_ChIP-Seq_U87_Human1.09423498
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09347431
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09330688
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08521498
89* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07972447
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.07875259
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07564514
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07217337
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.06974753
94TP53_18474530_ChIP-ChIP_U2OS_Human1.06284940
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05867265
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05667752
97* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05224733
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05224733
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04734510
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03413068
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02193682
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.01158898
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98262753
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98038625
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97188018
106* RUNX2_22187159_ChIP-Seq_PCA_Human0.96169444
107* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94333522
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93965247
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93965247
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93709049
111VDR_22108803_ChIP-Seq_LS180_Human0.92814585
112* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92536214
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91575912
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89792203
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.89170322
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88622588
117IGF1R_20145208_ChIP-Seq_DFB_Human0.87421203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.22801352
2MP0004084_abnormal_cardiac_muscle4.15966073
3MP0004215_abnormal_myocardial_fiber3.91095907
4MP0000751_myopathy3.52849216
5MP0004036_abnormal_muscle_relaxation3.11555535
6MP0005330_cardiomyopathy2.77588302
7MP0003137_abnormal_impulse_conducting2.59045653
8MP0004859_abnormal_synaptic_plasticity2.55427853
9MP0002972_abnormal_cardiac_muscle2.54322006
10MP0009780_abnormal_chondrocyte_physiolo2.52287995
11MP0000749_muscle_degeneration2.42354478
12MP0003646_muscle_fatigue2.38897888
13MP0004085_abnormal_heartbeat2.38016217
14MP0004145_abnormal_muscle_electrophysio2.31759434
15MP0005620_abnormal_muscle_contractility2.27435700
16MP0008775_abnormal_heart_ventricle2.24860839
17MP0004087_abnormal_muscle_fiber2.03285288
18MP0004484_altered_response_of1.94781498
19MP0006138_congestive_heart_failure1.93383854
20MP0003880_abnormal_central_pattern1.84385343
21MP0005385_cardiovascular_system_phenoty1.83194004
22MP0001544_abnormal_cardiovascular_syste1.83194004
23MP0010630_abnormal_cardiac_muscle1.81234214
24MP0002127_abnormal_cardiovascular_syste1.76903339
25MP0003635_abnormal_synaptic_transmissio1.71833905
26MP0004510_myositis1.69906351
27MP0002909_abnormal_adrenal_gland1.69370732
28MP0004270_analgesia1.66156113
29MP0002106_abnormal_muscle_physiology1.58479659
30MP0002269_muscular_atrophy1.56044980
31MP0005670_abnormal_white_adipose1.54346151
32MP0003122_maternal_imprinting1.49681916
33MP0004233_abnormal_muscle_weight1.49351242
34MP0004130_abnormal_muscle_cell1.46826954
35MP0002638_abnormal_pupillary_reflex1.39123145
36MP0005369_muscle_phenotype1.39004540
37MP0000750_abnormal_muscle_regeneration1.38692826
38MP0002063_abnormal_learning/memory/cond1.35481279
39MP0000013_abnormal_adipose_tissue1.34340794
40MP0004272_abnormal_basement_membrane1.33789696
41MP0002234_abnormal_pharynx_morphology1.31292828
42MP0002822_catalepsy1.31245365
43MP0010368_abnormal_lymphatic_system1.30114293
44MP0009745_abnormal_behavioral_response1.29248844
45MP0003136_yellow_coat_color1.21111334
46MP0003828_pulmonary_edema1.20963271
47MP0005623_abnormal_meninges_morphology1.17824176
48MP0001486_abnormal_startle_reflex1.16182832
49MP0000566_synostosis1.15034953
50MP0009384_cardiac_valve_regurgitation1.14137444
51MP0001529_abnormal_vocalization1.13973491
52MP0000747_muscle_weakness1.13456512
53MP0002572_abnormal_emotion/affect_behav1.11315851
54MP0006072_abnormal_retinal_apoptosis1.10775199
55MP0003879_abnormal_hair_cell1.09968884
56MP0000759_abnormal_skeletal_muscle1.07780007
57MP0002064_seizures1.07531915
58MP0005551_abnormal_eye_electrophysiolog1.05958637
59MP0003787_abnormal_imprinting1.04811218
60MP0002734_abnormal_mechanical_nocicepti1.03659360
61MP0002102_abnormal_ear_morphology0.99664398
62MP0004043_abnormal_pH_regulation0.99371873
63MP0010386_abnormal_urinary_bladder0.99089823
64MP0005253_abnormal_eye_physiology0.98945311
65MP0003283_abnormal_digestive_organ0.98849942
66MP0002272_abnormal_nervous_system0.97217743
67MP0009046_muscle_twitch0.96700293
68MP0002653_abnormal_ependyma_morphology0.93898414
69MP0005423_abnormal_somatic_nervous0.93551934
70MP0002876_abnormal_thyroid_physiology0.92640976
71MP0005646_abnormal_pituitary_gland0.92274406
72MP0000230_abnormal_systemic_arterial0.90859375
73MP0004133_heterotaxia0.90275208
74MP0004924_abnormal_behavior0.89126512
75MP0005386_behavior/neurological_phenoty0.89126512
76MP0002735_abnormal_chemical_nociception0.88986367
77MP0005187_abnormal_penis_morphology0.87528582
78MP0003252_abnormal_bile_duct0.85611447
79MP0001968_abnormal_touch/_nociception0.85266464
80MP0003567_abnormal_fetal_cardiomyocyte0.83941885
81MP0000266_abnormal_heart_morphology0.83600263
82MP0003221_abnormal_cardiomyocyte_apopto0.83419460
83MP0002067_abnormal_sensory_capabilities0.83305062
84MP0000778_abnormal_nervous_system0.83140069
85MP0003195_calcinosis0.82649882
86MP0003011_delayed_dark_adaptation0.81442714
87MP0000955_abnormal_spinal_cord0.80682476
88MP0005084_abnormal_gallbladder_morpholo0.80353870
89MP0002108_abnormal_muscle_morphology0.79932331
90MP0005085_abnormal_gallbladder_physiolo0.79576425
91MP0003045_fibrosis0.79070027
92MP0006276_abnormal_autonomic_nervous0.78921804
93MP0002184_abnormal_innervation0.78030151
94MP0004885_abnormal_endolymph0.77520333
95MP0001440_abnormal_grooming_behavior0.77481209
96MP0001485_abnormal_pinna_reflex0.75445492
97MP0001984_abnormal_olfaction0.75189027
98MP0005165_increased_susceptibility_to0.75044991
99MP0003950_abnormal_plasma_membrane0.72082861
100MP0002882_abnormal_neuron_morphology0.71580990
101MP0001299_abnormal_eye_distance/0.71126685
102MP0002078_abnormal_glucose_homeostasis0.70799165
103MP0003937_abnormal_limbs/digits/tail_de0.68682273
104MP0001944_abnormal_pancreas_morphology0.68296587
105MP0008569_lethality_at_weaning0.68013003
106MP0000631_abnormal_neuroendocrine_gland0.67528464
107MP0002557_abnormal_social/conspecific_i0.67525922
108MP0002752_abnormal_somatic_nervous0.67431945
109MP0001879_abnormal_lymphatic_vessel0.66600784
110MP0008961_abnormal_basal_metabolism0.65287989
111MP0000569_abnormal_digit_pigmentation0.64447830
112MP0002896_abnormal_bone_mineralization0.64354404
113MP0005595_abnormal_vascular_smooth0.64093035
114MP0004142_abnormal_muscle_tone0.64025262
115MP0005365_abnormal_bile_salt0.63930119
116MP0000026_abnormal_inner_ear0.63683731
117MP0001502_abnormal_circadian_rhythm0.63128775
118MP0000462_abnormal_digestive_system0.61382511
119MP0003279_aneurysm0.61176687
120MP0002928_abnormal_bile_duct0.60587299
121MP0008004_abnormal_stomach_pH0.59805059
122MP0001970_abnormal_pain_threshold0.59597231
123MP0002090_abnormal_vision0.58996369
124MP0000003_abnormal_adipose_tissue0.58912969
125MP0005248_abnormal_Harderian_gland0.57958519
126MP0002693_abnormal_pancreas_physiology0.56853730
127MP0003633_abnormal_nervous_system0.55946177

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.37711279
2Atrial fibrillation (HP:0005110)5.45370116
3Syncope (HP:0001279)5.24360826
4Primary atrial arrhythmia (HP:0001692)5.10902502
5Right ventricular cardiomyopathy (HP:0011663)4.89371131
6Supraventricular tachycardia (HP:0004755)4.81758181
7Ventricular tachycardia (HP:0004756)4.80045777
8Supraventricular arrhythmia (HP:0005115)4.75222405
9Calf muscle hypertrophy (HP:0008981)4.58558836
10Prolonged QT interval (HP:0001657)4.50367476
11Abnormality of the calf musculature (HP:0001430)4.45490091
12Muscle hypertrophy of the lower extremities (HP:0008968)4.15600537
13Abnormality of the left ventricular outflow tract (HP:0011103)4.12172759
14Subaortic stenosis (HP:0001682)4.12172759
15Ventricular arrhythmia (HP:0004308)3.90270099
16Lipoatrophy (HP:0100578)3.88275977
17Exercise-induced myalgia (HP:0003738)3.74800591
18Muscle fiber splitting (HP:0003555)3.67707520
19Bundle branch block (HP:0011710)3.64297521
20Ventricular fibrillation (HP:0001663)3.52775581
21Exercise-induced muscle cramps (HP:0003710)3.43701354
22Abnormal EKG (HP:0003115)3.35833340
23Hyperinsulinemic hypoglycemia (HP:0000825)3.34092163
24Hyporeflexia of lower limbs (HP:0002600)3.33150822
25Focal motor seizures (HP:0011153)3.28222868
26Dilated cardiomyopathy (HP:0001644)3.24581359
27Hypoglycemic coma (HP:0001325)3.21226562
28Palpitations (HP:0001962)3.14012592
29Heart block (HP:0012722)3.01495391
30Ketoacidosis (HP:0001993)2.95747662
31Atrioventricular block (HP:0001678)2.91099093
32EMG: myopathic abnormalities (HP:0003458)2.90701752
33Hypoplastic ischia (HP:0003175)2.80664375
34Abnormal atrioventricular conduction (HP:0005150)2.77367773
35Left ventricular hypertrophy (HP:0001712)2.77217092
36Asymmetric septal hypertrophy (HP:0001670)2.70342132
37Hypoglycemic seizures (HP:0002173)2.69110036
38Myoglobinuria (HP:0002913)2.60571157
39Hyperglycemia (HP:0003074)2.56855953
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54252048
41Abnormality of the ischium (HP:0003174)2.54150772
42Pancreatic islet-cell hyperplasia (HP:0004510)2.43379059
43Hyperventilation (HP:0002883)2.28324618
44Pheochromocytoma (HP:0002666)2.25986734
45Myotonia (HP:0002486)2.19972014
46Dysmetric saccades (HP:0000641)2.16661730
47Focal seizures (HP:0007359)2.16130073
48Epileptic encephalopathy (HP:0200134)2.12850754
49Central scotoma (HP:0000603)2.11050969
50Hypoplastic left heart (HP:0004383)2.06391296
51Bradycardia (HP:0001662)2.06008309
52Insulin-resistant diabetes mellitus (HP:0000831)2.04965478
53Symptomatic seizures (HP:0011145)2.00191136
54Decreased circulating renin level (HP:0003351)1.98532663
55Mildly elevated creatine phosphokinase (HP:0008180)1.94844046
56Steppage gait (HP:0003376)1.94285600
57Lymphangioma (HP:0100764)1.93608919
58Gait imbalance (HP:0002141)1.92806249
59Medial flaring of the eyebrow (HP:0010747)1.89907297
60Large for gestational age (HP:0001520)1.88862502
61Abnormality of the pancreatic islet cells (HP:0006476)1.88534424
62Abnormality of endocrine pancreas physiology (HP:0012093)1.88534424
63Sudden cardiac death (HP:0001645)1.88185178
64Ketosis (HP:0001946)1.86611883
65Drooling (HP:0002307)1.85761291
66Palmoplantar keratoderma (HP:0000982)1.85117218
67Broad-based gait (HP:0002136)1.84205651
68Neuroendocrine neoplasm (HP:0100634)1.82926077
69Difficulty running (HP:0009046)1.81972109
70Rimmed vacuoles (HP:0003805)1.78310460
71Visual hallucinations (HP:0002367)1.78174411
72Atonic seizures (HP:0010819)1.76525764
73Progressive cerebellar ataxia (HP:0002073)1.76310909
74Agitation (HP:0000713)1.71804735
75Congenital primary aphakia (HP:0007707)1.70989851
76Late onset (HP:0003584)1.70551923
77Nephronophthisis (HP:0000090)1.69585111
78Abnormality of the aortic arch (HP:0012303)1.69543598
79Pancreatic fibrosis (HP:0100732)1.69247453
80True hermaphroditism (HP:0010459)1.69206124
81Limited hip movement (HP:0008800)1.69098239
82Myokymia (HP:0002411)1.68934291
83Increased connective tissue (HP:0009025)1.68238287
84Neoplasm of the adrenal gland (HP:0100631)1.68018074
85Abnormality of the foot musculature (HP:0001436)1.67768392
86Increased variability in muscle fiber diameter (HP:0003557)1.67647055
87Hip contracture (HP:0003273)1.67539764
88Febrile seizures (HP:0002373)1.67283863
89Epileptiform EEG discharges (HP:0011182)1.67186078
90Skin nodule (HP:0200036)1.66498026
91Double outlet right ventricle (HP:0001719)1.66376659
92Congenital malformation of the right heart (HP:0011723)1.66376659
93Congestive heart failure (HP:0001635)1.66033896
94Patent foramen ovale (HP:0001655)1.65945073
95Poor eye contact (HP:0000817)1.64212848
96Generalized tonic-clonic seizures (HP:0002069)1.63756592
97EMG: neuropathic changes (HP:0003445)1.63624104
98Type 1 muscle fiber predominance (HP:0003803)1.63339831
99Vitreoretinal degeneration (HP:0000655)1.63179160
100Genital tract atresia (HP:0001827)1.61969089
101Hypoplastic heart (HP:0001961)1.61805986
102Abnormality of the pubic bones (HP:0003172)1.61538913
103Abnormality of the labia minora (HP:0012880)1.60806329
104EEG with generalized epileptiform discharges (HP:0011198)1.60228455
105Vaginal atresia (HP:0000148)1.59850843
106Excessive salivation (HP:0003781)1.59520890
107Lower limb amyotrophy (HP:0007210)1.58506416
108Anxiety (HP:0000739)1.58179608
109Neoplasm of the heart (HP:0100544)1.57591133
110Centrally nucleated skeletal muscle fibers (HP:0003687)1.56634971
111Muscular dystrophy (HP:0003560)1.56318400
112Neck muscle weakness (HP:0000467)1.55152439
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54798637
114Absence seizures (HP:0002121)1.53427761
115Pulmonary artery stenosis (HP:0004415)1.53274681
116Distal lower limb amyotrophy (HP:0008944)1.53242386
117Difficulty climbing stairs (HP:0003551)1.52980075
118Scanning speech (HP:0002168)1.52548774
119Impaired social interactions (HP:0000735)1.52417404
120Abnormal social behavior (HP:0012433)1.52417404
121Nephrogenic diabetes insipidus (HP:0009806)1.52058445
122Pachygyria (HP:0001302)1.51499589
123Hepatoblastoma (HP:0002884)1.50425539
124Distal lower limb muscle weakness (HP:0009053)1.50128712
125Aneurysm (HP:0002617)1.49536332
126Labial hypoplasia (HP:0000066)1.48072700
127Abnormality of the renal medulla (HP:0100957)1.46584294
128Blue irides (HP:0000635)1.42561012
129Poor coordination (HP:0002370)1.42410778
130Exotropia (HP:0000577)1.42251282
131Abnormal pancreas size (HP:0012094)1.41129973
132Preauricular pit (HP:0004467)1.40940305
133Periauricular skin pits (HP:0100277)1.40940305
134Action tremor (HP:0002345)1.39979020
135Congenital sensorineural hearing impairment (HP:0008527)1.37479595
136Polyphagia (HP:0002591)1.36850395
137Aplasia of the musculature (HP:0100854)1.35804857
138Pancreatic cysts (HP:0001737)1.34735076
139Maternal diabetes (HP:0009800)1.34674506
140Transposition of the great arteries (HP:0001669)1.33969704
141Abnormal connection of the cardiac segments (HP:0011545)1.33969704
142Abnormal ventriculo-arterial connection (HP:0011563)1.33969704
143Occipital encephalocele (HP:0002085)1.32388346
144Hypsarrhythmia (HP:0002521)1.31411337
145Hemiparesis (HP:0001269)1.31286380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.40215941
2OBSCN3.35734160
3EPHA42.93687986
4MYLK2.82238404
5NTRK32.76220640
6DMPK2.65619597
7PHKG12.22587629
8PHKG22.22587629
9MAP4K22.15177847
10LMTK22.05172535
11MAP3K41.91790532
12TTN1.86928322
13PAK31.84146766
14PIK3CA1.78804759
15EPHA31.67235114
16CASK1.62137227
17AKT31.60876829
18CDC42BPA1.59122687
19STK241.47852425
20MAP2K71.46148716
21PRKD31.46052716
22WNK41.45908322
23MUSK1.41334603
24SIK11.37010230
25DAPK21.36567816
26CAMK2D1.35001775
27MARK11.31836627
28MAP2K41.27987543
29TIE11.26357181
30MAP3K91.26064946
31LIMK11.25033191
32LATS11.24854437
33KSR11.21715780
34PAK61.20158181
35PNCK1.19504848
36PTK2B1.19279915
37CAMK2A1.18249615
38PKN21.17117983
39STK381.11171258
40ZAK1.10944043
41PDK41.10273657
42PDK31.10273657
43FER1.08131737
44FRK1.05528349
45DYRK21.05429398
46ROCK11.03571086
47CAMK11.01671507
48SGK21.01641861
49PRKCE1.00299161
50RIPK10.97836653
51PLK20.95539785
52STK38L0.92145855
53PDGFRA0.90384945
54UHMK10.86955418
55PRKD10.85540869
56BMPR1B0.83439379
57MINK10.82759031
58SGK4940.82727608
59SGK2230.82727608
60NTRK20.82627027
61STK110.80313407
62PINK10.80112031
63CAMK2B0.80000790
64CDK50.79491747
65KSR20.78097559
66PRKAA10.77787174
67CAMK1G0.77518851
68FGFR20.77340400
69MAPK130.77189280
70MAP3K60.77072806
71EPHB20.76794701
72CAMK40.76128791
73NTRK10.75978254
74DDR20.75851627
75SGK30.75714884
76ERBB30.75220143
77WNK10.74714135
78MAP3K70.74371731
79BCR0.73781270
80MAP3K20.72977768
81CAMKK10.72506273
82MARK20.72437285
83SGK10.70299044
84CAMKK20.69298696
85MAPK120.69177527
86TRIB30.68161191
87PRKAA20.66964386
88RET0.66920265
89PTK20.66207431
90MAP3K50.64162367
91PDK20.63743975
92FLT30.63220806
93DAPK30.63106447
94CAMK1D0.59010851
95NUAK10.59001408
96DYRK1A0.58880880
97MAP3K120.57060185
98CAMK2G0.56899115
99STK390.55710302
100PRKCH0.55413252
101STK30.55290794
102GRK10.53049690
103NLK0.51842474
104ILK0.51297212
105DYRK1B0.50732489
106TNIK0.50710169
107WNK30.50042631
108CSNK1G20.49617003
109PRKACG0.49493034
110PRKCG0.49490681
111PRKACA0.49097851
112ROCK20.48835463
113TRIM280.47064879
114MAPKAPK30.46691874
115MAPK150.45816049
116SIK30.44928471
117PKN10.44562155
118MAP2K10.44341203
119NEK90.44164026
120PRKCZ0.43382491
121GRK70.43081625
122PRKG10.42652484
123TRPM70.42333786
124DAPK10.41943351
125PRKACB0.41206562
126RPS6KA30.40819274
127DYRK30.39340471
128OXSR10.37173336
129CSNK1G10.37170668

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.98532979
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.73492612
3Cardiac muscle contraction_Homo sapiens_hsa042602.64312509
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58244081
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28252496
6Insulin secretion_Homo sapiens_hsa049112.13659129
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02326235
8Nicotine addiction_Homo sapiens_hsa050331.90166712
9Circadian entrainment_Homo sapiens_hsa047131.88469178
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86070928
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.72270902
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64926561
13Amphetamine addiction_Homo sapiens_hsa050311.61093060
14Long-term potentiation_Homo sapiens_hsa047201.54128540
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53267008
16GABAergic synapse_Homo sapiens_hsa047271.52929905
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49852827
18cGMP-PKG signaling pathway_Homo sapiens_hsa040221.48384385
19Glutamatergic synapse_Homo sapiens_hsa047241.46245534
20Olfactory transduction_Homo sapiens_hsa047401.45447255
21Morphine addiction_Homo sapiens_hsa050321.43206630
22Type II diabetes mellitus_Homo sapiens_hsa049301.42211194
23Renin secretion_Homo sapiens_hsa049241.41194986
24Oxytocin signaling pathway_Homo sapiens_hsa049211.41131898
25Dopaminergic synapse_Homo sapiens_hsa047281.32112261
26Calcium signaling pathway_Homo sapiens_hsa040201.32068714
27Taste transduction_Homo sapiens_hsa047421.31679971
28Fatty acid degradation_Homo sapiens_hsa000711.29318954
29Cholinergic synapse_Homo sapiens_hsa047251.24560890
30Salivary secretion_Homo sapiens_hsa049701.22800679
31Glucagon signaling pathway_Homo sapiens_hsa049221.19641415
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.18795697
33Propanoate metabolism_Homo sapiens_hsa006401.17953659
34Gastric acid secretion_Homo sapiens_hsa049711.17668650
35cAMP signaling pathway_Homo sapiens_hsa040241.17473380
36Cocaine addiction_Homo sapiens_hsa050301.16561624
37Phenylalanine metabolism_Homo sapiens_hsa003601.15053712
38Synaptic vesicle cycle_Homo sapiens_hsa047211.09481180
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08741661
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08407807
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06233231
42Fatty acid metabolism_Homo sapiens_hsa012121.04543147
43Linoleic acid metabolism_Homo sapiens_hsa005911.04313128
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03165556
45Butanoate metabolism_Homo sapiens_hsa006501.02256696
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99519839
47Serotonergic synapse_Homo sapiens_hsa047260.99113043
48Circadian rhythm_Homo sapiens_hsa047100.96007451
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94078205
50Alzheimers disease_Homo sapiens_hsa050100.93714819
51GnRH signaling pathway_Homo sapiens_hsa049120.88733846
52Pancreatic secretion_Homo sapiens_hsa049720.88193355
53Gap junction_Homo sapiens_hsa045400.87569965
54Tyrosine metabolism_Homo sapiens_hsa003500.87534686
55Insulin resistance_Homo sapiens_hsa049310.86871599
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86408718
57beta-Alanine metabolism_Homo sapiens_hsa004100.85864131
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.85138424
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84848496
60Nitrogen metabolism_Homo sapiens_hsa009100.83507652
61Retinol metabolism_Homo sapiens_hsa008300.83375660
62Caffeine metabolism_Homo sapiens_hsa002320.82159312
63Phototransduction_Homo sapiens_hsa047440.81674257
64Focal adhesion_Homo sapiens_hsa045100.81594991
65Oxidative phosphorylation_Homo sapiens_hsa001900.81481650
66Complement and coagulation cascades_Homo sapiens_hsa046100.80823803
67Long-term depression_Homo sapiens_hsa047300.80401040
68Melanogenesis_Homo sapiens_hsa049160.80241917
69Axon guidance_Homo sapiens_hsa043600.79937762
70Arginine biosynthesis_Homo sapiens_hsa002200.79374991
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77971655
72Parkinsons disease_Homo sapiens_hsa050120.76759106
73Adherens junction_Homo sapiens_hsa045200.76298592
74Dorso-ventral axis formation_Homo sapiens_hsa043200.76148877
75Ovarian steroidogenesis_Homo sapiens_hsa049130.75822076
76Insulin signaling pathway_Homo sapiens_hsa049100.75316783
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74650719
78Steroid biosynthesis_Homo sapiens_hsa001000.74644289
79Estrogen signaling pathway_Homo sapiens_hsa049150.73380744
80Chemical carcinogenesis_Homo sapiens_hsa052040.73122740
81Tight junction_Homo sapiens_hsa045300.72901250
82Hippo signaling pathway_Homo sapiens_hsa043900.72742747
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72046781
84Hedgehog signaling pathway_Homo sapiens_hsa043400.71981808
85Histidine metabolism_Homo sapiens_hsa003400.71328880
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70605557
87Bile secretion_Homo sapiens_hsa049760.69280196
88ECM-receptor interaction_Homo sapiens_hsa045120.67813880
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65348355
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64408964
91Lysine degradation_Homo sapiens_hsa003100.63727312
92Arginine and proline metabolism_Homo sapiens_hsa003300.63427912
93Tryptophan metabolism_Homo sapiens_hsa003800.63228817
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62636249
95ABC transporters_Homo sapiens_hsa020100.62148418
96Carbon metabolism_Homo sapiens_hsa012000.61747253
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61405180
98Pyruvate metabolism_Homo sapiens_hsa006200.61294264
99Starch and sucrose metabolism_Homo sapiens_hsa005000.61038865
100Basal cell carcinoma_Homo sapiens_hsa052170.59666531
101Peroxisome_Homo sapiens_hsa041460.59609411
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59319002
103Protein digestion and absorption_Homo sapiens_hsa049740.58470685
104AMPK signaling pathway_Homo sapiens_hsa041520.56499431
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56385158
106Regulation of autophagy_Homo sapiens_hsa041400.55830246
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55717211
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51210728
109PPAR signaling pathway_Homo sapiens_hsa033200.50185540
110Glioma_Homo sapiens_hsa052140.49903867
111Fat digestion and absorption_Homo sapiens_hsa049750.49810809
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49185610
113Sulfur metabolism_Homo sapiens_hsa009200.49152633
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49152177
115Vibrio cholerae infection_Homo sapiens_hsa051100.49055435
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49015455
117Viral myocarditis_Homo sapiens_hsa054160.48886970
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47578835
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47537117
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47533052
121ErbB signaling pathway_Homo sapiens_hsa040120.47309452
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.46633801
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45824914
124Huntingtons disease_Homo sapiens_hsa050160.44137099
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43718199
126Fatty acid elongation_Homo sapiens_hsa000620.40675519
127MAPK signaling pathway_Homo sapiens_hsa040100.40244995
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40010011
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.39921679
130Wnt signaling pathway_Homo sapiens_hsa043100.39854556

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