ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cardiac myofibril assembly (GO:0055003)	5.40715500
2	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	5.23557218
3	sarcomere organization (GO:0045214)	5.03143232
4	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	4.85315054
5	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.76892420
6	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.72648773
7	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.59132313
8	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	4.58310196
9	myofibril assembly (GO:0030239)	4.47666233
10	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.37584271
11	cardiac muscle hypertrophy (GO:0003300)	4.35341319
12	cell communication by electrical coupling (GO:0010644)	4.30255404
13	cell communication involved in cardiac conduction (GO:0086065)	4.17024978
14	cardiac muscle contraction (GO:0060048)	4.12152440
15	striated muscle hypertrophy (GO:0014897)	4.11189655
16	regulation of sarcomere organization (GO:0060297)	4.08127603
17	ventricular cardiac muscle cell action potential (GO:0086005)	4.03795350
18	detection of calcium ion (GO:0005513)	3.91366967
19	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.75418612
20	regulation of actin filament-based movement (GO:1903115)	3.74934812
21	regulation of membrane repolarization (GO:0060306)	3.72050574
22	cardiac muscle cell development (GO:0055013)	3.67853326
23	actomyosin structure organization (GO:0031032)	3.55562499
24	positive regulation of action potential (GO:0045760)	3.53432612
25	cardiac muscle tissue morphogenesis (GO:0055008)	3.53257089
26	muscle hypertrophy (GO:0014896)	3.52593024
27	regulation of cardioblast differentiation (GO:0051890)	3.51249227
28	cardiac cell development (GO:0055006)	3.46990220
29	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.44756943
30	actin-myosin filament sliding (GO:0033275)	3.44543263
31	muscle filament sliding (GO:0030049)	3.44543263
32	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.42786227
33	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	3.38537499
34	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.37086814
35	relaxation of cardiac muscle (GO:0055119)	3.37013912
36	cardiac conduction (GO:0061337)	3.36409898
37	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.35802052
38	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.34588094
39	muscle hypertrophy in response to stress (GO:0003299)	3.34588094
40	cardiac muscle adaptation (GO:0014887)	3.34588094
41	adult heart development (GO:0007512)	3.34445169
42	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.31219938
43	pyrimidine nucleobase catabolic process (GO:0006208)	3.31139899
44	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.30096653
45	plasma membrane repair (GO:0001778)	3.30045168
46	regulation of cell communication by electrical coupling (GO:0010649)	3.29555912
47	regulation of striated muscle contraction (GO:0006942)	3.25475910
48	heart trabecula formation (GO:0060347)	3.22489948
49	cardiac muscle cell action potential (GO:0086001)	3.20673746
50	regulation of relaxation of muscle (GO:1901077)	3.20624637
51	atrial septum morphogenesis (GO:0060413)	3.16929564
52	regulation of the force of heart contraction (GO:0002026)	3.16212519
53	regulation of cardiac muscle contraction (GO:0055117)	3.16110283
54	muscle tissue morphogenesis (GO:0060415)	3.15731923
55	cardiac chamber formation (GO:0003207)	3.14756855
56	regulation of heart rate by cardiac conduction (GO:0086091)	3.14755208
57	actin-mediated cell contraction (GO:0070252)	3.11597124
58	cardiac muscle cell action potential involved in contraction (GO:0086002)	3.08378411
59	striated muscle contraction (GO:0006941)	3.06330783
60	regulation of cardiac muscle cell contraction (GO:0086004)	3.06145552
61	regulation of ATPase activity (GO:0043462)	3.00961405
62	regulation of ATP catabolic process (GO:1903289)	3.00961405
63	regulation of heart rate (GO:0002027)	2.98762754
64	response to epinephrine (GO:0071871)	2.98638697
65	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.95611562
66	cellular response to epinephrine stimulus (GO:0071872)	2.94165584
67	membrane repolarization during action potential (GO:0086011)	2.92984657
68	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.90846934
69	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.89738411
70	response to inactivity (GO:0014854)	2.89199945
71	positive regulation of sodium ion transport (GO:0010765)	2.88433142
72	regulation of skeletal muscle contraction (GO:0014819)	2.86542551
73	negative regulation of protein localization to cell surface (GO:2000009)	2.84799413
74	carnitine shuttle (GO:0006853)	2.84116742
75	positive regulation of heart rate (GO:0010460)	2.83165148
76	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.77818416
77	regulation of calcium ion transmembrane transport (GO:1903169)	2.77028852
78	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.77028852
79	negative regulation of heart rate (GO:0010459)	2.76190052
80	nucleobase catabolic process (GO:0046113)	2.75895827
81	regulation of heart contraction (GO:0008016)	2.73933076
82	negative regulation of potassium ion transport (GO:0043267)	2.73125935
83	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.71956709
84	heart process (GO:0003015)	2.71466925
85	heart contraction (GO:0060047)	2.71466925
86	tricarboxylic acid cycle (GO:0006099)	2.69979263
87	positive regulation of heart contraction (GO:0045823)	2.68387943
88	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.68174609
89	positive regulation of muscle hypertrophy (GO:0014742)	2.68174609
90	positive regulation of cation channel activity (GO:2001259)	2.66447892
91	regulation of action potential (GO:0098900)	2.64344397
92	positive regulation of ATPase activity (GO:0032781)	2.63386124
93	positive regulation of ATP catabolic process (GO:1903291)	2.63386124
94	striated muscle cell development (GO:0055002)	2.61869619
95	regulation of potassium ion transmembrane transport (GO:1901379)	2.60261106
96	response to caffeine (GO:0031000)	2.59587836
97	axonal fasciculation (GO:0007413)	2.59549319
98	cardiac muscle tissue development (GO:0048738)	2.56961741
99	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.56172144
100	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.56099133
101	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.55711771
102	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.55387583
103	cardiac right ventricle morphogenesis (GO:0003215)	2.55140590
104	adrenergic receptor signaling pathway (GO:0071875)	2.54600688
105	vocalization behavior (GO:0071625)	2.54101901
106	cardiac ventricle formation (GO:0003211)	2.53694379
107	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.53672709
108	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.52663954
109	dendritic spine morphogenesis (GO:0060997)	2.52228673
110	multicellular organismal signaling (GO:0035637)	2.52007502
111	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.51695705
112	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.49680115
113	relaxation of muscle (GO:0090075)	2.49234377
114	actin filament-based movement (GO:0030048)	2.48755100
115	ventricular cardiac muscle cell development (GO:0055015)	2.46617057
116	regulation of glutamate receptor signaling pathway (GO:1900449)	2.46306511
117	regulation of voltage-gated calcium channel activity (GO:1901385)	2.46003255
118	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.44025721
119	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.43504779
120	fatty acid transmembrane transport (GO:1902001)	2.43484517
121	positive regulation of potassium ion transport (GO:0043268)	2.42927308
122	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.42853249
123	venous blood vessel morphogenesis (GO:0048845)	2.42280900
124	positive regulation of cardiac muscle tissue growth (GO:0055023)	2.41077028
125	cell junction maintenance (GO:0034331)	2.41023245
126	membrane repolarization (GO:0086009)	2.39859737
127	regulation of cation channel activity (GO:2001257)	2.38673615
128	activation of protein kinase A activity (GO:0034199)	2.38185108

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.54200321
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.05315531
3	* EP300_21415370_ChIP-Seq_HL-1_Mouse	2.63313861
4	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.44539110
5	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.34310080
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.14165669
7	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.11472835
8	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.11472835
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11252475
10	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.07444114
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.06177497
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.05433882
13	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.99939642
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.95158532
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.93301969
16	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.93099364
17	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.92272577
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.88843642
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.87124899
20	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.78553894
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77936615
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.72253578
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.66469564
24	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.65693690
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64939668
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61919727
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61422216
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.61389432
29	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.57298411
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.56559060
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54998651
32	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.54590618
33	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.52709307
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52276507
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.47898602
36	AHR_22903824_ChIP-Seq_MCF-7_Human	1.46520454
37	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.41794927
38	FUS_26573619_Chip-Seq_HEK293_Human	1.41344926
39	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.40309124
40	* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40143305
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39441997
42	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.39238565
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38903887
44	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.38274588
45	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.38056400
46	* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.37663489
47	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.37342786
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37323889
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36732438
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35809571
51	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35368013
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34717849
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33986769
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.32027745
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31921870
56	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.31803010
57	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.30858132
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.29452827
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27687169
60	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.27312351
61	P300_19829295_ChIP-Seq_ESCs_Human	1.25460153
62	* STAT3_23295773_ChIP-Seq_U87_Human	1.24444102
63	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.23985132
64	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.23985132
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23249940
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22345698
67	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.21555953
68	TP53_16413492_ChIP-PET_HCT116_Human	1.21480176
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21017869
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18638022
71	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.18474969
72	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.17996057
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17861693
74	* AR_19668381_ChIP-Seq_PC3_Human	1.16803492
75	* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.16344695
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16122228
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16015445
78	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15134737
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14504731
80	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.13910617
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12450013
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10813759
83	AR_25329375_ChIP-Seq_VCAP_Human	1.09902215
84	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.09755443
85	TCF4_23295773_ChIP-Seq_U87_Human	1.09423498
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09347431
87	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.09330688
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08521498
89	* MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.07972447
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07875259
91	* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.07564514
92	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.07217337
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06974753
94	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06284940
95	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.05867265
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05667752
97	* NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05224733
98	* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05224733
99	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.04734510
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03413068
101	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02193682
102	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.01158898
103	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.98262753
104	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98038625
105	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97188018
106	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.96169444
107	* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94333522
108	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93965247
109	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93965247
110	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93709049
111	VDR_22108803_ChIP-Seq_LS180_Human	0.92814585
112	* FOXA2_19822575_ChIP-Seq_HepG2_Human	0.92536214
113	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91575912
114	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.89792203
115	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.89170322
116	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88622588
117	IGF1R_20145208_ChIP-Seq_DFB_Human	0.87421203

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.22801352
2	MP0004084_abnormal_cardiac_muscle	4.15966073
3	MP0004215_abnormal_myocardial_fiber	3.91095907
4	MP0000751_myopathy	3.52849216
5	MP0004036_abnormal_muscle_relaxation	3.11555535
6	MP0005330_cardiomyopathy	2.77588302
7	MP0003137_abnormal_impulse_conducting	2.59045653
8	MP0004859_abnormal_synaptic_plasticity	2.55427853
9	MP0002972_abnormal_cardiac_muscle	2.54322006
10	MP0009780_abnormal_chondrocyte_physiolo	2.52287995
11	MP0000749_muscle_degeneration	2.42354478
12	MP0003646_muscle_fatigue	2.38897888
13	MP0004085_abnormal_heartbeat	2.38016217
14	MP0004145_abnormal_muscle_electrophysio	2.31759434
15	MP0005620_abnormal_muscle_contractility	2.27435700
16	MP0008775_abnormal_heart_ventricle	2.24860839
17	MP0004087_abnormal_muscle_fiber	2.03285288
18	MP0004484_altered_response_of	1.94781498
19	MP0006138_congestive_heart_failure	1.93383854
20	MP0003880_abnormal_central_pattern	1.84385343
21	MP0001544_abnormal_cardiovascular_syste	1.83194004
22	MP0005385_cardiovascular_system_phenoty	1.83194004
23	MP0010630_abnormal_cardiac_muscle	1.81234214
24	MP0002127_abnormal_cardiovascular_syste	1.76903339
25	MP0003635_abnormal_synaptic_transmissio	1.71833905
26	MP0004510_myositis	1.69906351
27	MP0002909_abnormal_adrenal_gland	1.69370732
28	MP0004270_analgesia	1.66156113
29	MP0002106_abnormal_muscle_physiology	1.58479659
30	MP0002269_muscular_atrophy	1.56044980
31	MP0005670_abnormal_white_adipose	1.54346151
32	MP0003122_maternal_imprinting	1.49681916
33	MP0004233_abnormal_muscle_weight	1.49351242
34	MP0004130_abnormal_muscle_cell	1.46826954
35	MP0002638_abnormal_pupillary_reflex	1.39123145
36	MP0005369_muscle_phenotype	1.39004540
37	MP0000750_abnormal_muscle_regeneration	1.38692826
38	MP0002063_abnormal_learning/memory/cond	1.35481279
39	MP0000013_abnormal_adipose_tissue	1.34340794
40	MP0004272_abnormal_basement_membrane	1.33789696
41	MP0002234_abnormal_pharynx_morphology	1.31292828
42	MP0002822_catalepsy	1.31245365
43	MP0010368_abnormal_lymphatic_system	1.30114293
44	MP0009745_abnormal_behavioral_response	1.29248844
45	MP0003136_yellow_coat_color	1.21111334
46	MP0003828_pulmonary_edema	1.20963271
47	MP0005623_abnormal_meninges_morphology	1.17824176
48	MP0001486_abnormal_startle_reflex	1.16182832
49	MP0000566_synostosis	1.15034953
50	MP0009384_cardiac_valve_regurgitation	1.14137444
51	MP0001529_abnormal_vocalization	1.13973491
52	MP0000747_muscle_weakness	1.13456512
53	MP0002572_abnormal_emotion/affect_behav	1.11315851
54	MP0006072_abnormal_retinal_apoptosis	1.10775199
55	MP0003879_abnormal_hair_cell	1.09968884
56	MP0000759_abnormal_skeletal_muscle	1.07780007
57	MP0002064_seizures	1.07531915
58	MP0005551_abnormal_eye_electrophysiolog	1.05958637
59	MP0003787_abnormal_imprinting	1.04811218
60	MP0002734_abnormal_mechanical_nocicepti	1.03659360
61	MP0002102_abnormal_ear_morphology	0.99664398
62	MP0004043_abnormal_pH_regulation	0.99371873
63	MP0010386_abnormal_urinary_bladder	0.99089823
64	MP0005253_abnormal_eye_physiology	0.98945311
65	MP0003283_abnormal_digestive_organ	0.98849942
66	MP0002272_abnormal_nervous_system	0.97217743
67	MP0009046_muscle_twitch	0.96700293
68	MP0002653_abnormal_ependyma_morphology	0.93898414
69	MP0005423_abnormal_somatic_nervous	0.93551934
70	MP0002876_abnormal_thyroid_physiology	0.92640976
71	MP0005646_abnormal_pituitary_gland	0.92274406
72	MP0000230_abnormal_systemic_arterial	0.90859375
73	MP0004133_heterotaxia	0.90275208
74	MP0004924_abnormal_behavior	0.89126512
75	MP0005386_behavior/neurological_phenoty	0.89126512
76	MP0002735_abnormal_chemical_nociception	0.88986367
77	MP0005187_abnormal_penis_morphology	0.87528582
78	MP0003252_abnormal_bile_duct	0.85611447
79	MP0001968_abnormal_touch/_nociception	0.85266464
80	MP0003567_abnormal_fetal_cardiomyocyte	0.83941885
81	MP0000266_abnormal_heart_morphology	0.83600263
82	MP0003221_abnormal_cardiomyocyte_apopto	0.83419460
83	MP0002067_abnormal_sensory_capabilities	0.83305062
84	MP0000778_abnormal_nervous_system	0.83140069
85	MP0003195_calcinosis	0.82649882
86	MP0003011_delayed_dark_adaptation	0.81442714
87	MP0000955_abnormal_spinal_cord	0.80682476
88	MP0005084_abnormal_gallbladder_morpholo	0.80353870
89	MP0002108_abnormal_muscle_morphology	0.79932331
90	MP0005085_abnormal_gallbladder_physiolo	0.79576425
91	MP0003045_fibrosis	0.79070027
92	MP0006276_abnormal_autonomic_nervous	0.78921804
93	MP0002184_abnormal_innervation	0.78030151
94	MP0004885_abnormal_endolymph	0.77520333
95	MP0001440_abnormal_grooming_behavior	0.77481209
96	MP0001485_abnormal_pinna_reflex	0.75445492
97	MP0001984_abnormal_olfaction	0.75189027
98	MP0005165_increased_susceptibility_to	0.75044991
99	MP0003950_abnormal_plasma_membrane	0.72082861
100	MP0002882_abnormal_neuron_morphology	0.71580990
101	MP0001299_abnormal_eye_distance/	0.71126685
102	MP0002078_abnormal_glucose_homeostasis	0.70799165
103	MP0003937_abnormal_limbs/digits/tail_de	0.68682273
104	MP0001944_abnormal_pancreas_morphology	0.68296587
105	MP0008569_lethality_at_weaning	0.68013003
106	MP0000631_abnormal_neuroendocrine_gland	0.67528464
107	MP0002557_abnormal_social/conspecific_i	0.67525922
108	MP0002752_abnormal_somatic_nervous	0.67431945
109	MP0001879_abnormal_lymphatic_vessel	0.66600784
110	MP0008961_abnormal_basal_metabolism	0.65287989
111	MP0000569_abnormal_digit_pigmentation	0.64447830
112	MP0002896_abnormal_bone_mineralization	0.64354404
113	MP0005595_abnormal_vascular_smooth	0.64093035
114	MP0004142_abnormal_muscle_tone	0.64025262
115	MP0005365_abnormal_bile_salt	0.63930119
116	MP0000026_abnormal_inner_ear	0.63683731
117	MP0001502_abnormal_circadian_rhythm	0.63128775
118	MP0000462_abnormal_digestive_system	0.61382511
119	MP0003279_aneurysm	0.61176687
120	MP0002928_abnormal_bile_duct	0.60587299
121	MP0008004_abnormal_stomach_pH	0.59805059
122	MP0001970_abnormal_pain_threshold	0.59597231
123	MP0002090_abnormal_vision	0.58996369
124	MP0000003_abnormal_adipose_tissue	0.58912969
125	MP0005248_abnormal_Harderian_gland	0.57958519
126	MP0002693_abnormal_pancreas_physiology	0.56853730
127	MP0003633_abnormal_nervous_system	0.55946177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sudden death (HP:0001699)	7.37711279
2	Atrial fibrillation (HP:0005110)	5.45370116
3	Syncope (HP:0001279)	5.24360826
4	Primary atrial arrhythmia (HP:0001692)	5.10902502
5	Right ventricular cardiomyopathy (HP:0011663)	4.89371131
6	Supraventricular tachycardia (HP:0004755)	4.81758181
7	Ventricular tachycardia (HP:0004756)	4.80045777
8	Supraventricular arrhythmia (HP:0005115)	4.75222405
9	Calf muscle hypertrophy (HP:0008981)	4.58558836
10	Prolonged QT interval (HP:0001657)	4.50367476
11	Abnormality of the calf musculature (HP:0001430)	4.45490091
12	Muscle hypertrophy of the lower extremities (HP:0008968)	4.15600537
13	Abnormality of the left ventricular outflow tract (HP:0011103)	4.12172759
14	Subaortic stenosis (HP:0001682)	4.12172759
15	Ventricular arrhythmia (HP:0004308)	3.90270099
16	Lipoatrophy (HP:0100578)	3.88275977
17	Exercise-induced myalgia (HP:0003738)	3.74800591
18	Muscle fiber splitting (HP:0003555)	3.67707520
19	Bundle branch block (HP:0011710)	3.64297521
20	Ventricular fibrillation (HP:0001663)	3.52775581
21	Exercise-induced muscle cramps (HP:0003710)	3.43701354
22	Abnormal EKG (HP:0003115)	3.35833340
23	Hyperinsulinemic hypoglycemia (HP:0000825)	3.34092163
24	Hyporeflexia of lower limbs (HP:0002600)	3.33150822
25	Focal motor seizures (HP:0011153)	3.28222868
26	Dilated cardiomyopathy (HP:0001644)	3.24581359
27	Hypoglycemic coma (HP:0001325)	3.21226562
28	Palpitations (HP:0001962)	3.14012592
29	Heart block (HP:0012722)	3.01495391
30	Ketoacidosis (HP:0001993)	2.95747662
31	Atrioventricular block (HP:0001678)	2.91099093
32	EMG: myopathic abnormalities (HP:0003458)	2.90701752
33	Hypoplastic ischia (HP:0003175)	2.80664375
34	Abnormal atrioventricular conduction (HP:0005150)	2.77367773
35	Left ventricular hypertrophy (HP:0001712)	2.77217092
36	Asymmetric septal hypertrophy (HP:0001670)	2.70342132
37	Hypoglycemic seizures (HP:0002173)	2.69110036
38	Myoglobinuria (HP:0002913)	2.60571157
39	Hyperglycemia (HP:0003074)	2.56855953
40	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.54252048
41	Abnormality of the ischium (HP:0003174)	2.54150772
42	Pancreatic islet-cell hyperplasia (HP:0004510)	2.43379059
43	Hyperventilation (HP:0002883)	2.28324618
44	Pheochromocytoma (HP:0002666)	2.25986734
45	Myotonia (HP:0002486)	2.19972014
46	Dysmetric saccades (HP:0000641)	2.16661730
47	Focal seizures (HP:0007359)	2.16130073
48	Epileptic encephalopathy (HP:0200134)	2.12850754
49	Central scotoma (HP:0000603)	2.11050969
50	Hypoplastic left heart (HP:0004383)	2.06391296
51	Bradycardia (HP:0001662)	2.06008309
52	Insulin-resistant diabetes mellitus (HP:0000831)	2.04965478
53	Symptomatic seizures (HP:0011145)	2.00191136
54	Decreased circulating renin level (HP:0003351)	1.98532663
55	Mildly elevated creatine phosphokinase (HP:0008180)	1.94844046
56	Steppage gait (HP:0003376)	1.94285600
57	Lymphangioma (HP:0100764)	1.93608919
58	Gait imbalance (HP:0002141)	1.92806249
59	Medial flaring of the eyebrow (HP:0010747)	1.89907297
60	Large for gestational age (HP:0001520)	1.88862502
61	Abnormality of endocrine pancreas physiology (HP:0012093)	1.88534424
62	Abnormality of the pancreatic islet cells (HP:0006476)	1.88534424
63	Sudden cardiac death (HP:0001645)	1.88185178
64	Ketosis (HP:0001946)	1.86611883
65	Drooling (HP:0002307)	1.85761291
66	Palmoplantar keratoderma (HP:0000982)	1.85117218
67	Broad-based gait (HP:0002136)	1.84205651
68	Neuroendocrine neoplasm (HP:0100634)	1.82926077
69	Difficulty running (HP:0009046)	1.81972109
70	Rimmed vacuoles (HP:0003805)	1.78310460
71	Visual hallucinations (HP:0002367)	1.78174411
72	Atonic seizures (HP:0010819)	1.76525764
73	Progressive cerebellar ataxia (HP:0002073)	1.76310909
74	Agitation (HP:0000713)	1.71804735
75	Congenital primary aphakia (HP:0007707)	1.70989851
76	Late onset (HP:0003584)	1.70551923
77	Nephronophthisis (HP:0000090)	1.69585111
78	Abnormality of the aortic arch (HP:0012303)	1.69543598
79	Pancreatic fibrosis (HP:0100732)	1.69247453
80	True hermaphroditism (HP:0010459)	1.69206124
81	Limited hip movement (HP:0008800)	1.69098239
82	Myokymia (HP:0002411)	1.68934291
83	Increased connective tissue (HP:0009025)	1.68238287
84	Neoplasm of the adrenal gland (HP:0100631)	1.68018074
85	Abnormality of the foot musculature (HP:0001436)	1.67768392
86	Increased variability in muscle fiber diameter (HP:0003557)	1.67647055
87	Hip contracture (HP:0003273)	1.67539764
88	Febrile seizures (HP:0002373)	1.67283863
89	Epileptiform EEG discharges (HP:0011182)	1.67186078
90	Skin nodule (HP:0200036)	1.66498026
91	Double outlet right ventricle (HP:0001719)	1.66376659
92	Congenital malformation of the right heart (HP:0011723)	1.66376659
93	Congestive heart failure (HP:0001635)	1.66033896
94	Patent foramen ovale (HP:0001655)	1.65945073
95	Poor eye contact (HP:0000817)	1.64212848
96	Generalized tonic-clonic seizures (HP:0002069)	1.63756592
97	EMG: neuropathic changes (HP:0003445)	1.63624104
98	Type 1 muscle fiber predominance (HP:0003803)	1.63339831
99	Vitreoretinal degeneration (HP:0000655)	1.63179160
100	Genital tract atresia (HP:0001827)	1.61969089
101	Hypoplastic heart (HP:0001961)	1.61805986
102	Abnormality of the pubic bones (HP:0003172)	1.61538913
103	Abnormality of the labia minora (HP:0012880)	1.60806329
104	EEG with generalized epileptiform discharges (HP:0011198)	1.60228455
105	Vaginal atresia (HP:0000148)	1.59850843
106	Excessive salivation (HP:0003781)	1.59520890
107	Lower limb amyotrophy (HP:0007210)	1.58506416
108	Anxiety (HP:0000739)	1.58179608
109	Neoplasm of the heart (HP:0100544)	1.57591133
110	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.56634971
111	Muscular dystrophy (HP:0003560)	1.56318400
112	Neck muscle weakness (HP:0000467)	1.55152439
113	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.54798637
114	Absence seizures (HP:0002121)	1.53427761
115	Pulmonary artery stenosis (HP:0004415)	1.53274681
116	Distal lower limb amyotrophy (HP:0008944)	1.53242386
117	Difficulty climbing stairs (HP:0003551)	1.52980075
118	Scanning speech (HP:0002168)	1.52548774
119	Impaired social interactions (HP:0000735)	1.52417404
120	Abnormal social behavior (HP:0012433)	1.52417404
121	Nephrogenic diabetes insipidus (HP:0009806)	1.52058445
122	Pachygyria (HP:0001302)	1.51499589
123	Hepatoblastoma (HP:0002884)	1.50425539
124	Distal lower limb muscle weakness (HP:0009053)	1.50128712
125	Aneurysm (HP:0002617)	1.49536332
126	Labial hypoplasia (HP:0000066)	1.48072700
127	Abnormality of the renal medulla (HP:0100957)	1.46584294
128	Blue irides (HP:0000635)	1.42561012
129	Poor coordination (HP:0002370)	1.42410778
130	Exotropia (HP:0000577)	1.42251282
131	Abnormal pancreas size (HP:0012094)	1.41129973
132	Periauricular skin pits (HP:0100277)	1.40940305
133	Preauricular pit (HP:0004467)	1.40940305
134	Action tremor (HP:0002345)	1.39979020
135	Congenital sensorineural hearing impairment (HP:0008527)	1.37479595
136	Polyphagia (HP:0002591)	1.36850395
137	Aplasia of the musculature (HP:0100854)	1.35804857
138	Pancreatic cysts (HP:0001737)	1.34735076
139	Maternal diabetes (HP:0009800)	1.34674506
140	Transposition of the great arteries (HP:0001669)	1.33969704
141	Abnormal connection of the cardiac segments (HP:0011545)	1.33969704
142	Abnormal ventriculo-arterial connection (HP:0011563)	1.33969704
143	Occipital encephalocele (HP:0002085)	1.32388346
144	Hypsarrhythmia (HP:0002521)	1.31411337
145	Hemiparesis (HP:0001269)	1.31286380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	3.40215941
2	OBSCN	3.35734160
3	EPHA4	2.93687986
4	MYLK	2.82238404
5	NTRK3	2.76220640
6	DMPK	2.65619597
7	PHKG2	2.22587629
8	PHKG1	2.22587629
9	MAP4K2	2.15177847
10	LMTK2	2.05172535
11	MAP3K4	1.91790532
12	TTN	1.86928322
13	PAK3	1.84146766
14	PIK3CA	1.78804759
15	EPHA3	1.67235114
16	CASK	1.62137227
17	AKT3	1.60876829
18	CDC42BPA	1.59122687
19	STK24	1.47852425
20	MAP2K7	1.46148716
21	PRKD3	1.46052716
22	WNK4	1.45908322
23	MUSK	1.41334603
24	SIK1	1.37010230
25	DAPK2	1.36567816
26	CAMK2D	1.35001775
27	MARK1	1.31836627
28	MAP2K4	1.27987543
29	TIE1	1.26357181
30	MAP3K9	1.26064946
31	LIMK1	1.25033191
32	LATS1	1.24854437
33	KSR1	1.21715780
34	PAK6	1.20158181
35	PNCK	1.19504848
36	PTK2B	1.19279915
37	CAMK2A	1.18249615
38	PKN2	1.17117983
39	STK38	1.11171258
40	ZAK	1.10944043
41	PDK3	1.10273657
42	PDK4	1.10273657
43	FER	1.08131737
44	FRK	1.05528349
45	DYRK2	1.05429398
46	ROCK1	1.03571086
47	CAMK1	1.01671507
48	SGK2	1.01641861
49	PRKCE	1.00299161
50	RIPK1	0.97836653
51	PLK2	0.95539785
52	STK38L	0.92145855
53	PDGFRA	0.90384945
54	UHMK1	0.86955418
55	PRKD1	0.85540869
56	BMPR1B	0.83439379
57	MINK1	0.82759031
58	SGK223	0.82727608
59	SGK494	0.82727608
60	NTRK2	0.82627027
61	STK11	0.80313407
62	PINK1	0.80112031
63	CAMK2B	0.80000790
64	CDK5	0.79491747
65	KSR2	0.78097559
66	PRKAA1	0.77787174
67	CAMK1G	0.77518851
68	FGFR2	0.77340400
69	MAPK13	0.77189280
70	MAP3K6	0.77072806
71	EPHB2	0.76794701
72	CAMK4	0.76128791
73	NTRK1	0.75978254
74	DDR2	0.75851627
75	SGK3	0.75714884
76	ERBB3	0.75220143
77	WNK1	0.74714135
78	MAP3K7	0.74371731
79	BCR	0.73781270
80	MAP3K2	0.72977768
81	CAMKK1	0.72506273
82	MARK2	0.72437285
83	SGK1	0.70299044
84	CAMKK2	0.69298696
85	MAPK12	0.69177527
86	TRIB3	0.68161191
87	PRKAA2	0.66964386
88	RET	0.66920265
89	PTK2	0.66207431
90	MAP3K5	0.64162367
91	PDK2	0.63743975
92	FLT3	0.63220806
93	DAPK3	0.63106447
94	CAMK1D	0.59010851
95	NUAK1	0.59001408
96	DYRK1A	0.58880880
97	MAP3K12	0.57060185
98	CAMK2G	0.56899115
99	STK39	0.55710302
100	PRKCH	0.55413252
101	STK3	0.55290794
102	GRK1	0.53049690
103	NLK	0.51842474
104	ILK	0.51297212
105	DYRK1B	0.50732489
106	TNIK	0.50710169
107	WNK3	0.50042631
108	CSNK1G2	0.49617003
109	PRKACG	0.49493034
110	PRKCG	0.49490681
111	PRKACA	0.49097851
112	ROCK2	0.48835463
113	TRIM28	0.47064879
114	MAPKAPK3	0.46691874
115	MAPK15	0.45816049
116	SIK3	0.44928471
117	PKN1	0.44562155
118	MAP2K1	0.44341203
119	NEK9	0.44164026
120	PRKCZ	0.43382491
121	GRK7	0.43081625
122	PRKG1	0.42652484
123	TRPM7	0.42333786
124	DAPK1	0.41943351
125	PRKACB	0.41206562
126	RPS6KA3	0.40819274
127	DYRK3	0.39340471
128	OXSR1	0.37173336
129	CSNK1G1	0.37170668

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.98532979
2	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.73492612
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.64312509
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.58244081
5	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.28252496
6	Insulin secretion_Homo sapiens_hsa04911	2.13659129
7	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.02326235
8	Nicotine addiction_Homo sapiens_hsa05033	1.90166712
9	Circadian entrainment_Homo sapiens_hsa04713	1.88469178
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.86070928
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72270902
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.64926561
13	Amphetamine addiction_Homo sapiens_hsa05031	1.61093060
14	Long-term potentiation_Homo sapiens_hsa04720	1.54128540
15	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.53267008
16	GABAergic synapse_Homo sapiens_hsa04727	1.52929905
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.49852827
18	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.48384385
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.46245534
20	Olfactory transduction_Homo sapiens_hsa04740	1.45447255
21	Morphine addiction_Homo sapiens_hsa05032	1.43206630
22	Type II diabetes mellitus_Homo sapiens_hsa04930	1.42211194
23	Renin secretion_Homo sapiens_hsa04924	1.41194986
24	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.41131898
25	Dopaminergic synapse_Homo sapiens_hsa04728	1.32112261
26	Calcium signaling pathway_Homo sapiens_hsa04020	1.32068714
27	Taste transduction_Homo sapiens_hsa04742	1.31679971
28	Fatty acid degradation_Homo sapiens_hsa00071	1.29318954
29	Cholinergic synapse_Homo sapiens_hsa04725	1.24560890
30	Salivary secretion_Homo sapiens_hsa04970	1.22800679
31	Glucagon signaling pathway_Homo sapiens_hsa04922	1.19641415
32	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.18795697
33	Propanoate metabolism_Homo sapiens_hsa00640	1.17953659
34	Gastric acid secretion_Homo sapiens_hsa04971	1.17668650
35	cAMP signaling pathway_Homo sapiens_hsa04024	1.17473380
36	Cocaine addiction_Homo sapiens_hsa05030	1.16561624
37	Phenylalanine metabolism_Homo sapiens_hsa00360	1.15053712
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09481180
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.08741661
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08407807
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06233231
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.04543147
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04313128
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03165556
45	Butanoate metabolism_Homo sapiens_hsa00650	1.02256696
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.99519839
47	Serotonergic synapse_Homo sapiens_hsa04726	0.99113043
48	Circadian rhythm_Homo sapiens_hsa04710	0.96007451
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94078205
50	Alzheimers disease_Homo sapiens_hsa05010	0.93714819
51	GnRH signaling pathway_Homo sapiens_hsa04912	0.88733846
52	Pancreatic secretion_Homo sapiens_hsa04972	0.88193355
53	Gap junction_Homo sapiens_hsa04540	0.87569965
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.87534686
55	Insulin resistance_Homo sapiens_hsa04931	0.86871599
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.86408718
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85864131
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85138424
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84848496
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.83507652
61	Retinol metabolism_Homo sapiens_hsa00830	0.83375660
62	Caffeine metabolism_Homo sapiens_hsa00232	0.82159312
63	Phototransduction_Homo sapiens_hsa04744	0.81674257
64	Focal adhesion_Homo sapiens_hsa04510	0.81594991
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.81481650
66	Complement and coagulation cascades_Homo sapiens_hsa04610	0.80823803
67	Long-term depression_Homo sapiens_hsa04730	0.80401040
68	Melanogenesis_Homo sapiens_hsa04916	0.80241917
69	Axon guidance_Homo sapiens_hsa04360	0.79937762
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.79374991
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.77971655
72	Parkinsons disease_Homo sapiens_hsa05012	0.76759106
73	Adherens junction_Homo sapiens_hsa04520	0.76298592
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76148877
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75822076
76	Insulin signaling pathway_Homo sapiens_hsa04910	0.75316783
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74650719
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.74644289
79	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73380744
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73122740
81	Tight junction_Homo sapiens_hsa04530	0.72901250
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.72742747
83	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.72046781
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71981808
85	Histidine metabolism_Homo sapiens_hsa00340	0.71328880
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70605557
87	Bile secretion_Homo sapiens_hsa04976	0.69280196
88	ECM-receptor interaction_Homo sapiens_hsa04512	0.67813880
89	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65348355
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.64408964
91	Lysine degradation_Homo sapiens_hsa00310	0.63727312
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63427912
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.63228817
94	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62636249
95	ABC transporters_Homo sapiens_hsa02010	0.62148418
96	Carbon metabolism_Homo sapiens_hsa01200	0.61747253
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61405180
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.61294264
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.61038865
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.59666531
101	Peroxisome_Homo sapiens_hsa04146	0.59609411
102	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.59319002
103	Protein digestion and absorption_Homo sapiens_hsa04974	0.58470685
104	AMPK signaling pathway_Homo sapiens_hsa04152	0.56499431
105	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56385158
106	Regulation of autophagy_Homo sapiens_hsa04140	0.55830246
107	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55717211
108	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51210728
109	PPAR signaling pathway_Homo sapiens_hsa03320	0.50185540
110	Glioma_Homo sapiens_hsa05214	0.49903867
111	Fat digestion and absorption_Homo sapiens_hsa04975	0.49810809
112	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.49185610
113	Sulfur metabolism_Homo sapiens_hsa00920	0.49152633
114	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49152177
115	Vibrio cholerae infection_Homo sapiens_hsa05110	0.49055435
116	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49015455
117	Viral myocarditis_Homo sapiens_hsa05416	0.48886970
118	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47578835
119	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47537117
120	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47533052
121	ErbB signaling pathway_Homo sapiens_hsa04012	0.47309452
122	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.46633801
123	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45824914
124	Huntingtons disease_Homo sapiens_hsa05016	0.44137099
125	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43718199
126	Fatty acid elongation_Homo sapiens_hsa00062	0.40675519
127	MAPK signaling pathway_Homo sapiens_hsa04010	0.40244995
128	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40010011
129	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39921679
130	Wnt signaling pathway_Homo sapiens_hsa04310	0.39854556

SORBS2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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