SORCS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.52615778
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.29153242
3vocalization behavior (GO:0071625)5.11941077
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.92871922
5synaptic vesicle maturation (GO:0016188)4.80534431
6pyrimidine nucleobase catabolic process (GO:0006208)4.80305677
7locomotory exploration behavior (GO:0035641)4.75238552
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64380237
9neuronal action potential propagation (GO:0019227)4.63911080
10protein localization to synapse (GO:0035418)4.56223648
11synaptic vesicle exocytosis (GO:0016079)4.41587624
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35013347
13presynaptic membrane assembly (GO:0097105)4.34039633
14regulation of synaptic vesicle exocytosis (GO:2000300)4.24138495
15regulation of glutamate receptor signaling pathway (GO:1900449)4.21716794
16axon ensheathment in central nervous system (GO:0032291)4.21549441
17central nervous system myelination (GO:0022010)4.21549441
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.18885952
19dendritic spine morphogenesis (GO:0060997)4.14441940
20neurotransmitter-gated ion channel clustering (GO:0072578)4.12176727
21neuron recognition (GO:0008038)4.09719175
22presynaptic membrane organization (GO:0097090)4.09096534
23glutamate secretion (GO:0014047)3.98588176
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.97671940
25transmission of nerve impulse (GO:0019226)3.95712814
26exploration behavior (GO:0035640)3.91041883
27layer formation in cerebral cortex (GO:0021819)3.90883722
28regulation of neuronal synaptic plasticity (GO:0048168)3.84844681
29nucleobase catabolic process (GO:0046113)3.79511524
30neuron-neuron synaptic transmission (GO:0007270)3.77584369
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77056169
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.75910089
33glutamate receptor signaling pathway (GO:0007215)3.75195841
34gamma-aminobutyric acid transport (GO:0015812)3.71324023
35synaptic transmission, glutamatergic (GO:0035249)3.67725005
36neurotransmitter secretion (GO:0007269)3.66936642
37postsynaptic membrane organization (GO:0001941)3.66057935
38regulation of synapse structural plasticity (GO:0051823)3.64990919
39axonal fasciculation (GO:0007413)3.64697138
40retinal ganglion cell axon guidance (GO:0031290)3.62263068
41neuronal stem cell maintenance (GO:0097150)3.61671341
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.53422710
43startle response (GO:0001964)3.51685856
44regulation of synaptic vesicle transport (GO:1902803)3.50895903
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50724679
46positive regulation of membrane potential (GO:0045838)3.43084556
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.42386216
48cell migration in hindbrain (GO:0021535)3.40252445
49central nervous system projection neuron axonogenesis (GO:0021952)3.39692321
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38587622
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35254164
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.33560420
53regulation of postsynaptic membrane potential (GO:0060078)3.30260718
54regulation of dendritic spine morphogenesis (GO:0061001)3.30014157
55neuronal ion channel clustering (GO:0045161)3.26702048
56tongue development (GO:0043586)3.25598233
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25409293
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24417273
59membrane hyperpolarization (GO:0060081)3.24262092
60prepulse inhibition (GO:0060134)3.23868681
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23125448
62long-term synaptic potentiation (GO:0060291)3.22548672
63synapse assembly (GO:0007416)3.20754085
64auditory behavior (GO:0031223)3.20511122
65adult walking behavior (GO:0007628)3.19904427
66establishment of mitochondrion localization (GO:0051654)3.18342115
67cerebral cortex radially oriented cell migration (GO:0021799)3.16851045
68negative regulation of neurotransmitter transport (GO:0051589)3.16069935
69neurotransmitter transport (GO:0006836)3.15339887
70neuromuscular synaptic transmission (GO:0007274)3.15104347
71innervation (GO:0060384)3.12943718
72behavioral response to cocaine (GO:0048148)3.12695871
73long-term memory (GO:0007616)3.12514770
74enteric nervous system development (GO:0048484)3.09426243
75positive regulation of synapse assembly (GO:0051965)3.09298614
76L-amino acid import (GO:0043092)3.07877260
77mechanosensory behavior (GO:0007638)3.06461990
78cerebellar granule cell differentiation (GO:0021707)3.06196274
79regulation of synaptic plasticity (GO:0048167)3.05444139
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.04993728
81negative regulation of oligodendrocyte differentiation (GO:0048715)3.03894226
82dendrite morphogenesis (GO:0048813)3.03374706
83response to histamine (GO:0034776)3.02961550
84cochlea development (GO:0090102)3.02149120
85neuromuscular process controlling balance (GO:0050885)2.99447423
86synapse organization (GO:0050808)2.99363641
87cranial nerve development (GO:0021545)2.99235874
88behavioral defense response (GO:0002209)2.97502289
89behavioral fear response (GO:0001662)2.97502289
90regulation of dendritic spine development (GO:0060998)2.96884018
91response to auditory stimulus (GO:0010996)2.95858776
92proline transport (GO:0015824)2.94375836
93mating behavior (GO:0007617)2.92336920
94ensheathment of neurons (GO:0007272)2.92092210
95axon ensheathment (GO:0008366)2.92092210
96myelination (GO:0042552)2.92018904
97glycine transport (GO:0015816)2.91796495
98establishment of nucleus localization (GO:0040023)2.91731121
99central nervous system neuron axonogenesis (GO:0021955)2.90956645
100regulation of neurotransmitter levels (GO:0001505)2.90909412
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88728137
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.88705992
103membrane depolarization (GO:0051899)2.88614277
104regulation of synaptic transmission, GABAergic (GO:0032228)2.88388134
105regulation of voltage-gated calcium channel activity (GO:1901385)2.87728426
106cerebellar Purkinje cell differentiation (GO:0021702)2.87697960
107negative regulation of neurotransmitter secretion (GO:0046929)2.87027127
108regulation of neurotransmitter secretion (GO:0046928)2.86223903
109behavioral response to nicotine (GO:0035095)2.85934527
110regulation of glutamate secretion (GO:0014048)2.85623808
111positive regulation of synapse maturation (GO:0090129)2.85456401
112retinal cone cell development (GO:0046549)2.85119172
113learning (GO:0007612)2.84958417
114long-chain fatty acid biosynthetic process (GO:0042759)2.84645414
115positive regulation of dendritic spine development (GO:0060999)2.84470760
116activation of protein kinase A activity (GO:0034199)2.84014830
117striatum development (GO:0021756)2.83818272
118cellular potassium ion homeostasis (GO:0030007)2.83757561
119regulation of respiratory system process (GO:0044065)2.80675960
120regulation of synapse assembly (GO:0051963)2.80314640
121nonmotile primary cilium assembly (GO:0035058)2.79679714
122neuromuscular process controlling posture (GO:0050884)2.76354323
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75234125
124neuromuscular process (GO:0050905)2.74405676
125neuron projection extension involved in neuron projection guidance (GO:1902284)2.72984997
126axon extension involved in axon guidance (GO:0048846)2.72984997
127positive regulation of synaptic transmission (GO:0050806)2.72931393
128fear response (GO:0042596)2.72404051
129sodium ion export (GO:0071436)2.72133358
130forebrain neuron differentiation (GO:0021879)2.70520696
131cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70436829
132regulation of development, heterochronic (GO:0040034)2.70045860
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68405857
134mitochondrion transport along microtubule (GO:0047497)2.68405857
135regulation of respiratory gaseous exchange (GO:0043576)2.66420530
136neuron fate determination (GO:0048664)2.66303980
137membrane depolarization during action potential (GO:0086010)2.66031124
138regulation of timing of cell differentiation (GO:0048505)2.65348043
139C4-dicarboxylate transport (GO:0015740)2.58901479
140synaptic vesicle endocytosis (GO:0048488)2.58204558
141negative regulation of glial cell differentiation (GO:0045686)2.57309448
142suckling behavior (GO:0001967)2.57019843
143cell communication by electrical coupling (GO:0010644)2.55817112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37051152
2GBX2_23144817_ChIP-Seq_PC3_Human3.82068337
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12192077
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07072995
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06724177
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71050152
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71050152
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.70871285
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62322402
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58019517
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56357296
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54211230
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44971520
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.42826734
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39379294
16AR_21572438_ChIP-Seq_LNCaP_Human2.33598474
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22588952
18* TAF15_26573619_Chip-Seq_HEK293_Human2.21759094
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.20472434
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.18284009
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18026528
22DROSHA_22980978_ChIP-Seq_HELA_Human2.14070996
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09437989
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08189184
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.05989077
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02260070
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82825490
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77633990
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77589735
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.77184031
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75567991
32* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72317262
33* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68042464
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65597517
35SMAD4_21799915_ChIP-Seq_A2780_Human1.65440550
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.65101035
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61907314
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61807271
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61044959
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60311934
41P300_19829295_ChIP-Seq_ESCs_Human1.55440702
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53418484
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53012510
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42864864
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42505103
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42497162
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.41405080
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41110348
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.39280254
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37221956
51ZNF274_21170338_ChIP-Seq_K562_Hela1.35299523
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.33561208
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29914235
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29573485
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28888512
56SOX9_26525672_Chip-Seq_HEART_Mouse1.28666152
57STAT3_23295773_ChIP-Seq_U87_Human1.28578881
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28006008
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.26693974
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26314649
61* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26307854
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.25583274
63EWS_26573619_Chip-Seq_HEK293_Human1.24307377
64* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22307208
65ER_23166858_ChIP-Seq_MCF-7_Human1.22197498
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.21702128
67* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21214923
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20036937
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19164310
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18174352
71IGF1R_20145208_ChIP-Seq_DFB_Human1.18009345
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17848882
73AR_25329375_ChIP-Seq_VCAP_Human1.16999232
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.15704296
75* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15654187
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15567788
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15497729
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.15321276
79* FUS_26573619_Chip-Seq_HEK293_Human1.15263506
80VDR_22108803_ChIP-Seq_LS180_Human1.13642986
81* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13063531
82AHR_22903824_ChIP-Seq_MCF-7_Human1.12790751
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.12311293
84* TCF4_23295773_ChIP-Seq_U87_Human1.11825266
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11762723
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09068550
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08957037
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.07871364
89* AR_19668381_ChIP-Seq_PC3_Human1.07766284
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07271033
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06958329
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06932783
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06748486
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.06085165
95* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05880149
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05815642
97TP53_16413492_ChIP-PET_HCT116_Human1.05658383
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03948507
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03568536
100RUNX2_22187159_ChIP-Seq_PCA_Human1.03245534
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02798007
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01294910
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00082890
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99969637
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99931471
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98517791
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.98443504
108TP53_18474530_ChIP-ChIP_U2OS_Human0.98439173
109BCAT_22108803_ChIP-Seq_LS180_Human0.98354261
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.97904366
111* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96898518
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95116257
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95116257
114* JUN_21703547_ChIP-Seq_K562_Human0.93802658
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.92491077
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92064853
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91749342
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88257674
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88120663
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88095858
121* KDM2B_26808549_Chip-Seq_REH_Human0.87620575
122* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87375104
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.86940490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.96205948
2MP0003880_abnormal_central_pattern4.95580082
3MP0003635_abnormal_synaptic_transmissio3.69911338
4MP0004270_analgesia3.59270141
5MP0009745_abnormal_behavioral_response3.23928065
6MP0005423_abnormal_somatic_nervous3.22363777
7MP0002064_seizures3.09950275
8MP0009046_muscle_twitch2.95169882
9MP0002063_abnormal_learning/memory/cond2.92353285
10MP0002822_catalepsy2.89785949
11MP0002272_abnormal_nervous_system2.86903680
12MP0001486_abnormal_startle_reflex2.85957808
13MP0001968_abnormal_touch/_nociception2.82782102
14MP0002572_abnormal_emotion/affect_behav2.69871192
15MP0002734_abnormal_mechanical_nocicepti2.59161356
16MP0005248_abnormal_Harderian_gland2.31757391
17MP0000778_abnormal_nervous_system2.20818112
18MP0000920_abnormal_myelination2.18121344
19MP0000569_abnormal_digit_pigmentation2.10101300
20MP0001501_abnormal_sleep_pattern2.06276390
21MP0002067_abnormal_sensory_capabilities2.03254126
22MP0002638_abnormal_pupillary_reflex2.02833388
23MP0002735_abnormal_chemical_nociception2.02439696
24MP0001440_abnormal_grooming_behavior1.99007932
25MP0001529_abnormal_vocalization1.97064158
26MP0002733_abnormal_thermal_nociception1.96606126
27MP0002736_abnormal_nociception_after1.96445724
28MP0006276_abnormal_autonomic_nervous1.92509762
29MP0001970_abnormal_pain_threshold1.90596662
30MP0002184_abnormal_innervation1.79926849
31MP0002557_abnormal_social/conspecific_i1.79707735
32MP0004885_abnormal_endolymph1.77896723
33MP0006292_abnormal_olfactory_placode1.74657890
34MP0008569_lethality_at_weaning1.74338268
35MP0002653_abnormal_ependyma_morphology1.68088005
36MP0004924_abnormal_behavior1.65510979
37MP0005386_behavior/neurological_phenoty1.65510979
38MP0004742_abnormal_vestibular_system1.62423972
39MP0000955_abnormal_spinal_cord1.59735049
40MP0001984_abnormal_olfaction1.57806438
41MP0004142_abnormal_muscle_tone1.57104797
42MP0002882_abnormal_neuron_morphology1.56759241
43MP0003122_maternal_imprinting1.51941301
44MP0005645_abnormal_hypothalamus_physiol1.51263126
45MP0001905_abnormal_dopamine_level1.50782451
46* MP0003329_amyloid_beta_deposits1.49919598
47MP0003634_abnormal_glial_cell1.48773239
48MP0010030_abnormal_orbit_morphology1.48650283
49MP0000566_synostosis1.47520831
50MP0002938_white_spotting1.46839001
51MP0009780_abnormal_chondrocyte_physiolo1.46757462
52MP0004811_abnormal_neuron_physiology1.46317798
53MP0003121_genomic_imprinting1.45687245
54MP0002066_abnormal_motor_capabilities/c1.45224144
55MP0005187_abnormal_penis_morphology1.45110971
56MP0005551_abnormal_eye_electrophysiolog1.43569758
57MP0005646_abnormal_pituitary_gland1.41461299
58MP0003690_abnormal_glial_cell1.37504074
59MP0004133_heterotaxia1.37377579
60MP0008789_abnormal_olfactory_epithelium1.35450740
61MP0005409_darkened_coat_color1.34055286
62MP0001485_abnormal_pinna_reflex1.32145877
63MP0003879_abnormal_hair_cell1.29837001
64MP0001188_hyperpigmentation1.28220996
65MP0002229_neurodegeneration1.25859437
66MP0001293_anophthalmia1.25276420
67MP0001502_abnormal_circadian_rhythm1.21056857
68MP0003633_abnormal_nervous_system1.20866882
69MP0001346_abnormal_lacrimal_gland1.19705576
70MP0004145_abnormal_muscle_electrophysio1.19653858
71MP0002909_abnormal_adrenal_gland1.19251157
72MP0004858_abnormal_nervous_system1.17107356
73MP0002152_abnormal_brain_morphology1.15934154
74* MP0003631_nervous_system_phenotype1.12690753
75MP0003890_abnormal_embryonic-extraembry1.12610025
76MP0002752_abnormal_somatic_nervous1.07855736
77MP0001963_abnormal_hearing_physiology1.07745545
78MP0002697_abnormal_eye_size1.06386181
79MP0001177_atelectasis1.03365320
80MP0003136_yellow_coat_color1.02901326
81* MP0003632_abnormal_nervous_system1.01394288
82MP0003119_abnormal_digestive_system1.00618641
83MP0003937_abnormal_limbs/digits/tail_de0.99454550
84MP0005623_abnormal_meninges_morphology0.98763779
85MP0002102_abnormal_ear_morphology0.97248508
86MP0005171_absent_coat_pigmentation0.96673986
87MP0005391_vision/eye_phenotype0.96198653
88MP0000751_myopathy0.93909578
89MP0002233_abnormal_nose_morphology0.93662536
90MP0000631_abnormal_neuroendocrine_gland0.93295189
91MP0000049_abnormal_middle_ear0.91219457
92MP0003787_abnormal_imprinting0.90180456
93MP0001299_abnormal_eye_distance/0.89467117
94MP0001286_abnormal_eye_development0.87238290
95MP0003942_abnormal_urinary_system0.85051633
96MP0002069_abnormal_eating/drinking_beha0.84746822
97MP0000026_abnormal_inner_ear0.81477387
98MP0004085_abnormal_heartbeat0.81042586
99MP0000579_abnormal_nail_morphology0.80318680
100MP0001324_abnormal_eye_pigmentation0.78903940
101MP0003385_abnormal_body_wall0.78227351
102MP0002249_abnormal_larynx_morphology0.77753413
103MP0008874_decreased_physiological_sensi0.76106029
104MP0000013_abnormal_adipose_tissue0.75921555
105MP0006072_abnormal_retinal_apoptosis0.75813749
106MP0005174_abnormal_tail_pigmentation0.75736536
107MP0000647_abnormal_sebaceous_gland0.73700412
108MP0002090_abnormal_vision0.71257906
109MP0002081_perinatal_lethality0.71147301
110MP0001943_abnormal_respiration0.71138555
111MP0005253_abnormal_eye_physiology0.70015923
112MP0003861_abnormal_nervous_system0.69596931
113MP0005195_abnormal_posterior_eye0.69548162
114MP0003938_abnormal_ear_development0.67914631
115MP0008872_abnormal_physiological_respon0.66652539
116MP0003137_abnormal_impulse_conducting0.64394630
117MP0002751_abnormal_autonomic_nervous0.63387866
118MP0000747_muscle_weakness0.60454447
119MP0001664_abnormal_digestion0.58625659
120MP0004043_abnormal_pH_regulation0.57522332
121MP0005394_taste/olfaction_phenotype0.56313807
122MP0005499_abnormal_olfactory_system0.56313807
123MP0010770_preweaning_lethality0.55828456
124MP0002082_postnatal_lethality0.55828456
125MP0010769_abnormal_survival0.53645747
126MP0005535_abnormal_body_temperature0.53409471
127MP0003283_abnormal_digestive_organ0.53147067
128MP0000462_abnormal_digestive_system0.52991879
129MP0000534_abnormal_ureter_morphology0.51876587
130MP0010386_abnormal_urinary_bladder0.50764723
131MP0002837_dystrophic_cardiac_calcinosis0.50640084

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.01029941
2Myokymia (HP:0002411)5.76210516
3Focal seizures (HP:0007359)5.18112594
4Atonic seizures (HP:0010819)4.57165092
5Insidious onset (HP:0003587)4.31982573
6Termporal pattern (HP:0011008)4.31982573
7Epileptic encephalopathy (HP:0200134)4.31232243
8Action tremor (HP:0002345)4.11846406
9Visual hallucinations (HP:0002367)3.72009325
10Febrile seizures (HP:0002373)3.70682249
11Absence seizures (HP:0002121)3.68410118
12Neurofibrillary tangles (HP:0002185)3.65766034
13Supranuclear gaze palsy (HP:0000605)3.51218220
14Ankle clonus (HP:0011448)3.48211722
15Dialeptic seizures (HP:0011146)3.45803973
16Hyperventilation (HP:0002883)3.45537271
17Broad-based gait (HP:0002136)3.41619545
18Generalized tonic-clonic seizures (HP:0002069)3.31251749
19Progressive cerebellar ataxia (HP:0002073)3.30927695
20Peripheral hypomyelination (HP:0007182)3.27584916
21Ulnar claw (HP:0001178)3.23751247
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.14271469
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.14271469
24Cerebral inclusion bodies (HP:0100314)3.11043227
25Abnormality of the corticospinal tract (HP:0002492)3.10027651
26Septo-optic dysplasia (HP:0100842)3.08443071
27Poor eye contact (HP:0000817)3.01691045
28Progressive inability to walk (HP:0002505)2.93787834
29Oligodactyly (HP:0012165)2.92855622
30Spastic gait (HP:0002064)2.90372854
31Dysmetria (HP:0001310)2.87549185
32Truncal ataxia (HP:0002078)2.84379609
33Onion bulb formation (HP:0003383)2.81886137
34Impaired social interactions (HP:0000735)2.81440026
35Abnormal social behavior (HP:0012433)2.81440026
36Scanning speech (HP:0002168)2.80807486
37Oligodactyly (hands) (HP:0001180)2.80233592
38Gaze-evoked nystagmus (HP:0000640)2.78384548
39Drooling (HP:0002307)2.74644253
40Excessive salivation (HP:0003781)2.74644253
41Absent speech (HP:0001344)2.74329009
42Dysdiadochokinesis (HP:0002075)2.73982244
43Hemiparesis (HP:0001269)2.61655204
44Optic nerve hypoplasia (HP:0000609)2.59981994
45Vitreoretinal degeneration (HP:0000655)2.57271404
46Intestinal atresia (HP:0011100)2.53880203
47True hermaphroditism (HP:0010459)2.53618355
48Esophageal atresia (HP:0002032)2.52849985
49Short 4th metacarpal (HP:0010044)2.48855721
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48855721
51Impaired vibration sensation in the lower limbs (HP:0002166)2.46882769
52Sensory axonal neuropathy (HP:0003390)2.46270546
53Genital tract atresia (HP:0001827)2.46018735
54Anxiety (HP:0000739)2.44221777
55Depression (HP:0000716)2.44054322
56Abnormal eating behavior (HP:0100738)2.43018475
57Amblyopia (HP:0000646)2.42259350
58Segmental peripheral demyelination/remyelination (HP:0003481)2.41888927
59Vaginal atresia (HP:0000148)2.41201462
60Pheochromocytoma (HP:0002666)2.40849703
61Urinary bladder sphincter dysfunction (HP:0002839)2.40674534
62Mutism (HP:0002300)2.38966701
63Pancreatic fibrosis (HP:0100732)2.38298327
64Intention tremor (HP:0002080)2.38110459
65Medial flaring of the eyebrow (HP:0010747)2.37210852
66Congenital primary aphakia (HP:0007707)2.36746035
67Rib fusion (HP:0000902)2.35861979
68Urinary urgency (HP:0000012)2.34047750
69Hammertoe (HP:0001765)2.31307637
70Megalencephaly (HP:0001355)2.31093819
71Lower limb muscle weakness (HP:0007340)2.30086941
72Akinesia (HP:0002304)2.29273487
73Anophthalmia (HP:0000528)2.28467979
74Blue irides (HP:0000635)2.26934490
75Abnormality of the diencephalon (HP:0010662)2.26666226
76Postural instability (HP:0002172)2.26553627
77Chronic hepatic failure (HP:0100626)2.25836544
78Split foot (HP:0001839)2.25161620
79Limb dystonia (HP:0002451)2.23879354
80Pancreatic cysts (HP:0001737)2.22480202
81Nephronophthisis (HP:0000090)2.22234150
82Inability to walk (HP:0002540)2.21271111
83Renal dysplasia (HP:0000110)2.20718321
84Gastrointestinal atresia (HP:0002589)2.20616122
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19738390
86Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18787628
87Abnormality of the 4th metacarpal (HP:0010012)2.17775283
88Postural tremor (HP:0002174)2.16869416
89Generalized myoclonic seizures (HP:0002123)2.16572336
90Hepatoblastoma (HP:0002884)2.15352756
91Epileptiform EEG discharges (HP:0011182)2.13605319
92Nephrogenic diabetes insipidus (HP:0009806)2.12185112
93EEG with generalized epileptiform discharges (HP:0011198)2.10040400
94Steppage gait (HP:0003376)2.08776714
95Torticollis (HP:0000473)2.07803984
96Cutaneous finger syndactyly (HP:0010554)2.07234522
97Diplopia (HP:0000651)2.07194119
98Abnormality of binocular vision (HP:0011514)2.07194119
99Molar tooth sign on MRI (HP:0002419)2.06686001
100Abnormality of midbrain morphology (HP:0002418)2.06686001
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06549292
102Abnormality of the labia minora (HP:0012880)2.03613831
103Postaxial hand polydactyly (HP:0001162)2.02778878
104Abnormality of the aortic arch (HP:0012303)2.02174263
105Agitation (HP:0000713)2.01871338
106Renal hypoplasia (HP:0000089)2.01259256
107Thickened helices (HP:0000391)2.00624583
108Neuroendocrine neoplasm (HP:0100634)2.00237615
109Hypsarrhythmia (HP:0002521)1.99149529
110Genetic anticipation (HP:0003743)1.98708135
111Hemivertebrae (HP:0002937)1.97987706
112Clumsiness (HP:0002312)1.97573955
113Polyphagia (HP:0002591)1.97347725
114Fetal akinesia sequence (HP:0001989)1.97165549
115Cortical dysplasia (HP:0002539)1.97121877
116Decreased motor nerve conduction velocity (HP:0003431)1.95034940
117Specific learning disability (HP:0001328)1.94969459
118Abnormal auditory evoked potentials (HP:0006958)1.91711306
119Papilledema (HP:0001085)1.90230944
120Broad foot (HP:0001769)1.90075533
121Poor coordination (HP:0002370)1.89898895
122Stereotypic behavior (HP:0000733)1.89224921
123Absent septum pellucidum (HP:0001331)1.89143131
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.88300323
125Clonus (HP:0002169)1.88074444
126Gait ataxia (HP:0002066)1.87216484
127Lissencephaly (HP:0001339)1.86238674
128Abnormality of salivation (HP:0100755)1.85670410
129Widely spaced teeth (HP:0000687)1.85178545
130Occipital encephalocele (HP:0002085)1.81667343
131Cutaneous syndactyly (HP:0012725)1.80747600
132Aqueductal stenosis (HP:0002410)1.80162713
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.79840769
134Bowel incontinence (HP:0002607)1.79643602
135Retinal dysplasia (HP:0007973)1.79049076
136Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78215056
137Focal dystonia (HP:0004373)1.77647415
138Sclerocornea (HP:0000647)1.76541911
139Preaxial foot polydactyly (HP:0001841)1.76471661
140Midline defect of the nose (HP:0004122)1.76390590
141Aplasia involving bones of the upper limbs (HP:0009823)1.76227533
142Aplasia of the phalanges of the hand (HP:0009802)1.76227533
143Aplasia involving bones of the extremities (HP:0009825)1.76227533
144Growth hormone deficiency (HP:0000824)1.75598463
145Hemiplegia (HP:0002301)1.75377242
146Spastic tetraplegia (HP:0002510)1.73466549
147Gait imbalance (HP:0002141)1.73127031
148Neuronal loss in central nervous system (HP:0002529)1.72876888
149Esotropia (HP:0000565)1.72415373
150Foot dorsiflexor weakness (HP:0009027)1.70669264
151Postaxial foot polydactyly (HP:0001830)1.70586721
152Anencephaly (HP:0002323)1.70228898
153Impaired smooth pursuit (HP:0007772)1.69801986
154Shawl scrotum (HP:0000049)1.68963377
155Colon cancer (HP:0003003)1.68673877
156Supernumerary spleens (HP:0009799)1.68403798
157Cystic liver disease (HP:0006706)1.67685862
158Short tibia (HP:0005736)1.67525225
159Chorioretinal coloboma (HP:0000567)1.65960439
160Preaxial hand polydactyly (HP:0001177)1.65043365
161Synostosis involving the elbow (HP:0003938)1.65033684
162Humeroradial synostosis (HP:0003041)1.65033684
163Abnormality of the renal medulla (HP:0100957)1.65024486
164Narrow forehead (HP:0000341)1.64686822
165Hyperglycinemia (HP:0002154)1.64207223
166Abnormality of the septum pellucidum (HP:0007375)1.63934383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.88445632
2NTRK33.87723468
3CASK3.10463192
4MARK12.90220493
5MAP3K92.81434774
6MAP3K42.55936126
7STK392.47548136
8MAP4K22.45332796
9NTRK12.20949496
10TNIK2.19831357
11OXSR12.15677827
12NTRK22.09823365
13MAP2K72.08302002
14PAK62.07227664
15MINK11.95417363
16PNCK1.91477546
17DAPK21.82375289
18DYRK21.72938095
19CDK191.69477112
20UHMK11.68723033
21MAP3K121.62343247
22EPHB21.53282037
23CDK51.47867271
24KSR21.47852407
25PINK11.46497364
26PRPF4B1.45539628
27MAP2K41.41383287
28RIPK41.41189288
29PLK21.35653345
30KSR11.33733481
31MAPK131.33328135
32MKNK21.29146333
33TYRO31.29101644
34FES1.22294697
35PKN11.21919280
36BCR1.18714338
37MUSK1.17823022
38WNK41.16847285
39BMPR1B1.11382034
40SGK2231.11239551
41SGK4941.11239551
42CAMK2A1.11151246
43CAMKK11.10262334
44PAK31.08446684
45PRKD31.06733762
46MKNK11.05205809
47CAMKK21.03656261
48CSNK1G21.03615740
49FRK1.03511506
50WNK11.03474753
51FGFR21.03436411
52CAMK2B0.97886475
53CDK140.95985407
54PHKG10.95623456
55PHKG20.95623456
56GRK50.95518116
57SIK20.93320213
58MAP3K20.92796173
59PRKCG0.92667304
60ERBB40.92214368
61CDK180.91585438
62CDK150.90622381
63NEK60.90301329
64ROCK20.89536804
65MAPKAPK50.88128186
66ARAF0.82824377
67MARK20.82328693
68CAMK1G0.81639612
69STK110.79666042
70CDK11A0.77419224
71BMPR20.77215589
72STK380.76866965
73INSRR0.76305252
74PRKCE0.76071025
75MAPK150.75932936
76CSNK1G30.74090947
77CAMK2D0.73847541
78PLK40.73389130
79EPHA30.72477403
80FGR0.71612761
81EPHB10.70019434
82CSNK1A1L0.67723460
83DAPK10.67698337
84SGK10.67277802
85DYRK1B0.66465505
86DYRK1A0.66285438
87CAMK10.64525483
88PRKCH0.64075138
89WNK30.61142961
90ERBB20.60721974
91ERBB30.60353829
92LIMK10.58593699
93CAMK2G0.58301316
94IRAK20.58192946
95ICK0.57661627
96CDK30.57529826
97FYN0.57399962
98MAP3K130.57006843
99SGK30.55632142
100CCNB10.55094351
101RET0.53853730
102OBSCN0.52654955
103MAP3K100.50340718
104LATS20.49776297
105PDPK10.49422339
106TSSK60.48790591
107RPS6KA30.48601704
108SGK20.47369048
109PRKCZ0.47215035
110CSNK1G10.46693759
111DYRK30.46509984
112CAMK40.45990707
113PTK2B0.45708315
114DDR20.44589883
115MAPK100.44246823
116STK38L0.43577223
117MOS0.42942180
118AKT30.42539782
119CSNK1D0.42350743
120ADRBK10.41905046
121PRKACB0.40919352
122BRD40.39763291
123TRIM280.39735395
124RAF10.39121597
125GRK70.38780441
126ADRBK20.38698769
127ROCK10.38170025
128CDC42BPA0.36004339
129PRKCQ0.35894583
130PRKACA0.35894305
131CSNK1E0.33970666
132PRKG10.32397443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50097180
2GABAergic synapse_Homo sapiens_hsa047272.90179170
3Synaptic vesicle cycle_Homo sapiens_hsa047212.86045145
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66141505
5Glutamatergic synapse_Homo sapiens_hsa047242.59616074
6Morphine addiction_Homo sapiens_hsa050322.56497363
7Circadian entrainment_Homo sapiens_hsa047132.43782734
8Olfactory transduction_Homo sapiens_hsa047402.26642667
9Long-term potentiation_Homo sapiens_hsa047202.12281073
10Amphetamine addiction_Homo sapiens_hsa050312.08710456
11Dopaminergic synapse_Homo sapiens_hsa047282.07331172
12Serotonergic synapse_Homo sapiens_hsa047262.03848707
13Salivary secretion_Homo sapiens_hsa049701.97580174
14Long-term depression_Homo sapiens_hsa047301.86661504
15Cholinergic synapse_Homo sapiens_hsa047251.86466599
16Basal cell carcinoma_Homo sapiens_hsa052171.81368817
17Cocaine addiction_Homo sapiens_hsa050301.80571720
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78831341
19Taste transduction_Homo sapiens_hsa047421.76872008
20Gastric acid secretion_Homo sapiens_hsa049711.72031720
21Renin secretion_Homo sapiens_hsa049241.70542455
22Insulin secretion_Homo sapiens_hsa049111.67766832
23Axon guidance_Homo sapiens_hsa043601.65713355
24Collecting duct acid secretion_Homo sapiens_hsa049661.54916542
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49324951
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48567565
27Oxytocin signaling pathway_Homo sapiens_hsa049211.47541330
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47094762
29Phototransduction_Homo sapiens_hsa047441.42355835
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41142849
31Gap junction_Homo sapiens_hsa045401.40000291
32Calcium signaling pathway_Homo sapiens_hsa040201.39687746
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27845032
34Hippo signaling pathway_Homo sapiens_hsa043901.24354489
35GnRH signaling pathway_Homo sapiens_hsa049121.21029860
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18278456
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17117708
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16053257
39Vibrio cholerae infection_Homo sapiens_hsa051101.14250648
40Cardiac muscle contraction_Homo sapiens_hsa042601.13367095
41cAMP signaling pathway_Homo sapiens_hsa040241.12239682
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11114082
43Dorso-ventral axis formation_Homo sapiens_hsa043201.10104283
44Propanoate metabolism_Homo sapiens_hsa006401.09583603
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04512999
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03054544
47ErbB signaling pathway_Homo sapiens_hsa040121.02485548
48Melanogenesis_Homo sapiens_hsa049161.01221827
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99952202
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99314865
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.99047714
52Estrogen signaling pathway_Homo sapiens_hsa049150.95646945
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91312092
54Circadian rhythm_Homo sapiens_hsa047100.90976354
55Glioma_Homo sapiens_hsa052140.90092153
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88455900
57Ether lipid metabolism_Homo sapiens_hsa005650.87935664
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.87768520
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87316291
60Dilated cardiomyopathy_Homo sapiens_hsa054140.87014886
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85602990
62Type II diabetes mellitus_Homo sapiens_hsa049300.84719460
63Pancreatic secretion_Homo sapiens_hsa049720.76111832
64Alzheimers disease_Homo sapiens_hsa050100.72671695
65Ras signaling pathway_Homo sapiens_hsa040140.72432982
66Oxidative phosphorylation_Homo sapiens_hsa001900.71882053
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69539887
68MAPK signaling pathway_Homo sapiens_hsa040100.69487804
69Renal cell carcinoma_Homo sapiens_hsa052110.66624104
70Steroid biosynthesis_Homo sapiens_hsa001000.66518536
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65934891
72Thyroid hormone synthesis_Homo sapiens_hsa049180.65709234
73Butanoate metabolism_Homo sapiens_hsa006500.65488661
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65015335
75Choline metabolism in cancer_Homo sapiens_hsa052310.64886364
76Oocyte meiosis_Homo sapiens_hsa041140.63321275
77Nitrogen metabolism_Homo sapiens_hsa009100.62597555
78Alcoholism_Homo sapiens_hsa050340.61756556
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.61316328
80Fatty acid elongation_Homo sapiens_hsa000620.61062781
81Prion diseases_Homo sapiens_hsa050200.59354131
82Ovarian steroidogenesis_Homo sapiens_hsa049130.58743824
83Type I diabetes mellitus_Homo sapiens_hsa049400.57552974
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56560616
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56507888
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55978669
87Parkinsons disease_Homo sapiens_hsa050120.55160162
88Wnt signaling pathway_Homo sapiens_hsa043100.53961498
89Hedgehog signaling pathway_Homo sapiens_hsa043400.53945844
90Fanconi anemia pathway_Homo sapiens_hsa034600.53155053
91Rap1 signaling pathway_Homo sapiens_hsa040150.52148583
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.50440063
93Huntingtons disease_Homo sapiens_hsa050160.48961554
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48134249
95Endocytosis_Homo sapiens_hsa041440.46708173
96Tight junction_Homo sapiens_hsa045300.46645241
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43678229
98Endometrial cancer_Homo sapiens_hsa052130.43447035
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43286057
100TGF-beta signaling pathway_Homo sapiens_hsa043500.42607455
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41939959
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41877994
103Bile secretion_Homo sapiens_hsa049760.41786275
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41297700
105Fatty acid metabolism_Homo sapiens_hsa012120.40969479
106Vitamin B6 metabolism_Homo sapiens_hsa007500.40744928
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40091199
108Inositol phosphate metabolism_Homo sapiens_hsa005620.39425786
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38979936
110Rheumatoid arthritis_Homo sapiens_hsa053230.38281834
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.37754099
112Colorectal cancer_Homo sapiens_hsa052100.36042532
113African trypanosomiasis_Homo sapiens_hsa051430.35348738
114Notch signaling pathway_Homo sapiens_hsa043300.33715074
115Protein export_Homo sapiens_hsa030600.32823064
116Chemokine signaling pathway_Homo sapiens_hsa040620.31379015
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31095709
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31050129
119VEGF signaling pathway_Homo sapiens_hsa043700.30875562
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29991296
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.28630626
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.28435895
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28006308

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »