SORCS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.60967821
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48028483
3synaptic vesicle maturation (GO:0016188)4.07521592
4layer formation in cerebral cortex (GO:0021819)3.99121368
5central nervous system myelination (GO:0022010)3.97113422
6axon ensheathment in central nervous system (GO:0032291)3.97113422
7vocalization behavior (GO:0071625)3.96504383
8presynaptic membrane organization (GO:0097090)3.91160895
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89987422
10presynaptic membrane assembly (GO:0097105)3.82881355
11pyrimidine nucleobase catabolic process (GO:0006208)3.79541305
12sodium ion export (GO:0071436)3.78706659
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.76036594
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75274913
15regulation of synapse structural plasticity (GO:0051823)3.69801659
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65798312
17cerebellar granule cell differentiation (GO:0021707)3.60361532
18dendritic spine morphogenesis (GO:0060997)3.59466996
19exploration behavior (GO:0035640)3.58368377
20cellular potassium ion homeostasis (GO:0030007)3.54608137
21synaptic vesicle exocytosis (GO:0016079)3.39407008
22regulation of glutamate receptor signaling pathway (GO:1900449)3.37330190
23proline transport (GO:0015824)3.28153707
24protein localization to synapse (GO:0035418)3.25926079
25regulation of neuronal synaptic plasticity (GO:0048168)3.25316222
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24740420
27glutamate secretion (GO:0014047)3.22896245
28positive regulation of synapse assembly (GO:0051965)3.22381059
29auditory behavior (GO:0031223)3.16857512
30cell communication by electrical coupling (GO:0010644)3.14935352
31regulation of synaptic vesicle exocytosis (GO:2000300)3.14708887
32innervation (GO:0060384)3.14272554
33cell-cell junction maintenance (GO:0045217)3.13504044
34axonal fasciculation (GO:0007413)3.11039738
35positive regulation of synapse maturation (GO:0090129)3.09027017
36postsynaptic membrane organization (GO:0001941)3.06997366
37cellular sodium ion homeostasis (GO:0006883)3.06676664
38axon extension (GO:0048675)3.06625455
39nucleobase catabolic process (GO:0046113)3.00879458
40activation of protein kinase A activity (GO:0034199)2.97741187
41dendrite morphogenesis (GO:0048813)2.97458028
42neuron cell-cell adhesion (GO:0007158)2.96850541
43transmission of nerve impulse (GO:0019226)2.95678326
44neurotransmitter-gated ion channel clustering (GO:0072578)2.93282116
45establishment of nucleus localization (GO:0040023)2.92510408
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91453032
47negative regulation of catenin import into nucleus (GO:0035414)2.88490766
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88039615
49membrane assembly (GO:0071709)2.87556218
50response to auditory stimulus (GO:0010996)2.87553805
51ionotropic glutamate receptor signaling pathway (GO:0035235)2.87121732
52neurotransmitter secretion (GO:0007269)2.86289562
53neuron recognition (GO:0008038)2.82850477
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82473079
55peripheral nervous system axon ensheathment (GO:0032292)2.80954972
56myelination in peripheral nervous system (GO:0022011)2.80954972
57regulation of dendritic spine morphogenesis (GO:0061001)2.79476372
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78470679
59cytoskeletal anchoring at plasma membrane (GO:0007016)2.77746035
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75506506
61neuromuscular process controlling balance (GO:0050885)2.74521624
62positive regulation of dendritic spine morphogenesis (GO:0061003)2.73458647
63gamma-aminobutyric acid transport (GO:0015812)2.73373775
64synaptic transmission, glutamatergic (GO:0035249)2.73001129
65prepulse inhibition (GO:0060134)2.70476209
66glutamate receptor signaling pathway (GO:0007215)2.68627508
67regulation of synaptic vesicle transport (GO:1902803)2.66367429
68neuron projection extension (GO:1990138)2.65870610
69positive regulation of dendritic spine development (GO:0060999)2.65774542
70neuronal action potential propagation (GO:0019227)2.64943590
71dendritic spine organization (GO:0097061)2.64380046
72glial cell proliferation (GO:0014009)2.63591707
73regulation of synapse assembly (GO:0051963)2.63191460
74cerebral cortex radially oriented cell migration (GO:0021799)2.62619000
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62502195
76regulation of axon guidance (GO:1902667)2.61807096
77apical protein localization (GO:0045176)2.59472340
78cell migration in hindbrain (GO:0021535)2.59021386
79alanine transport (GO:0032328)2.57700325
80L-amino acid import (GO:0043092)2.56898065
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56886731
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.55615238
83mating behavior (GO:0007617)2.55605615
84negative regulation of sodium ion transport (GO:0010766)2.54970151
85potassium ion import (GO:0010107)2.53816874
86regulation of synaptic plasticity (GO:0048167)2.52395429
87synapse assembly (GO:0007416)2.51043940
88retinal ganglion cell axon guidance (GO:0031290)2.50630232
89potassium ion homeostasis (GO:0055075)2.50553951
90long-term memory (GO:0007616)2.50099456
91spinal cord development (GO:0021510)2.49071723
92cerebellar Purkinje cell differentiation (GO:0021702)2.48944110
93negative regulation of axonogenesis (GO:0050771)2.48370530
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47672023
95startle response (GO:0001964)2.46665630
96regulation of neurotransmitter secretion (GO:0046928)2.45673159
97short-term memory (GO:0007614)2.45465758
98neuron-neuron synaptic transmission (GO:0007270)2.45388294
99regulation of synapse organization (GO:0050807)2.44972834
100cell differentiation in hindbrain (GO:0021533)2.44672656
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.44492685
102neuromuscular junction development (GO:0007528)2.44178738
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43888545
104synapse organization (GO:0050808)2.43557999
105amino acid import (GO:0043090)2.43082386
106regulation of respiratory system process (GO:0044065)2.43051614
107positive regulation of vesicle fusion (GO:0031340)2.42835994
108positive regulation of gastrulation (GO:2000543)2.41564596
109neurotransmitter transport (GO:0006836)2.41042799
110cell junction maintenance (GO:0034331)2.39509422
111long-term synaptic potentiation (GO:0060291)2.38429030
112gonadal mesoderm development (GO:0007506)2.38334252
113regulation of postsynaptic membrane potential (GO:0060078)2.37905056
114glycine transport (GO:0015816)2.37437776
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.36082279
116plasma membrane repair (GO:0001778)2.35603794
117synaptic vesicle endocytosis (GO:0048488)2.35084328
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34881682
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.34583215
120axon extension involved in axon guidance (GO:0048846)2.34583215
121negative regulation of fatty acid transport (GO:2000192)2.34381836
122protein heterotrimerization (GO:0070208)2.33550432
123neuronal ion channel clustering (GO:0045161)2.33264545
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.32772125
125regulation of vesicle fusion (GO:0031338)2.32406388
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31394078
127positive regulation of axon extension (GO:0045773)2.30962920
128ovulation cycle (GO:0042698)2.30902462
129neuromuscular synaptic transmission (GO:0007274)2.29185037
130central nervous system projection neuron axonogenesis (GO:0021952)2.28968043
131myoblast fusion (GO:0007520)2.27804648
132mechanosensory behavior (GO:0007638)2.26853150
133regulation of axon extension involved in axon guidance (GO:0048841)2.26736484
134stress fiber assembly (GO:0043149)2.25299667
135membrane repolarization (GO:0086009)2.25050339
136regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24984947
137membrane depolarization during action potential (GO:0086010)2.24907694
138regulation of dendritic spine development (GO:0060998)2.24280693
139regulation of synapse maturation (GO:0090128)2.24218669
140dermatan sulfate biosynthetic process (GO:0030208)2.24092091
141camera-type eye morphogenesis (GO:0048593)2.23877569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44170135
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88980188
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71440427
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69401937
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69401937
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64923467
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50682346
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44532110
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43733499
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.40187611
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.39192021
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36645215
13DROSHA_22980978_ChIP-Seq_HELA_Human2.36285184
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35339405
15GBX2_23144817_ChIP-Seq_PC3_Human2.34636061
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.33995683
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.26276833
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21692201
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13007078
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08373451
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03089351
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.02962783
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02847970
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99327563
25AR_21572438_ChIP-Seq_LNCaP_Human1.94133329
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92223681
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86127635
28REST_21632747_ChIP-Seq_MESCs_Mouse1.63725833
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59152686
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57796909
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56629368
32KDM2B_26808549_Chip-Seq_K562_Human1.54555376
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54398178
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54139023
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53396261
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52728964
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52269515
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.52128077
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49705179
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48782005
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48738829
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44912561
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42311103
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.40032867
45RNF2_27304074_Chip-Seq_NSC_Mouse1.34905565
46* REST_18959480_ChIP-ChIP_MESCs_Mouse1.32462995
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.32297619
48AHR_22903824_ChIP-Seq_MCF-7_Human1.32045677
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31754269
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29494023
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28722830
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28204284
53* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27660861
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.25888958
55* AR_19668381_ChIP-Seq_PC3_Human1.25335625
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.23726134
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22154658
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21607325
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19318603
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18111937
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16685417
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.16405866
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.16218863
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16004655
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15965297
66* EP300_21415370_ChIP-Seq_HL-1_Mouse1.15358028
67CTCF_27219007_Chip-Seq_Bcells_Human1.15276078
68SMAD4_21799915_ChIP-Seq_A2780_Human1.14993913
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14818848
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14601721
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13367048
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11113717
73* TP53_16413492_ChIP-PET_HCT116_Human1.10472626
74TP53_18474530_ChIP-ChIP_U2OS_Human1.09307109
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08842377
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08736533
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07669630
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.07614847
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.07509432
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07388861
81* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06514910
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05238558
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04227932
84ZNF274_21170338_ChIP-Seq_K562_Hela1.02573176
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.02327971
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.98561405
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.98127353
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.97758934
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94950075
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94690943
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.94188842
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.93483584
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93320240
94* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92699589
95AR_25329375_ChIP-Seq_VCAP_Human0.91609003
96* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90891666
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90866848
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90866848
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90794540
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90750491
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90260794
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90207386
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90020896
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89471131
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.88878628
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88360000
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87503062
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85934537
109* GATA1_26923725_Chip-Seq_HPCs_Mouse0.85586682
110* STAT3_23295773_ChIP-Seq_U87_Human0.85549305
111RXR_22108803_ChIP-Seq_LS180_Human0.85511488
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85267181
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84770506
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83889526
115KDM2B_26808549_Chip-Seq_DND41_Human0.83329376
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83064291
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82520277
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82374639
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81604847
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78595160
121* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78370741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.63646165
2MP0003635_abnormal_synaptic_transmissio2.81079416
3MP0004270_analgesia2.75579756
4MP0008438_abnormal_cutaneous_collagen2.75462158
5MP0000566_synostosis2.74504256
6MP0009780_abnormal_chondrocyte_physiolo2.60457472
7MP0005623_abnormal_meninges_morphology2.39925279
8MP0002063_abnormal_learning/memory/cond2.24206352
9MP0005503_abnormal_tendon_morphology2.24154553
10MP0003880_abnormal_central_pattern2.19417466
11MP0000751_myopathy2.06543624
12MP0004858_abnormal_nervous_system2.04122542
13MP0009745_abnormal_behavioral_response2.00985416
14MP0005423_abnormal_somatic_nervous1.92131781
15MP0005275_abnormal_skin_tensile1.84983942
16MP0002909_abnormal_adrenal_gland1.83263732
17MP0002822_catalepsy1.82964533
18MP0002064_seizures1.78808055
19MP0002572_abnormal_emotion/affect_behav1.76208265
20MP0001486_abnormal_startle_reflex1.75635226
21MP0003283_abnormal_digestive_organ1.74967786
22MP0004272_abnormal_basement_membrane1.73843561
23MP0002734_abnormal_mechanical_nocicepti1.68691165
24MP0010030_abnormal_orbit_morphology1.67961460
25MP0003705_abnormal_hypodermis_morpholog1.66458904
26MP0000013_abnormal_adipose_tissue1.65402974
27MP0003122_maternal_imprinting1.64216114
28MP0003279_aneurysm1.61445503
29MP0001299_abnormal_eye_distance/1.54888586
30MP0001958_emphysema1.53957825
31MP0000778_abnormal_nervous_system1.52913892
32MP0004742_abnormal_vestibular_system1.52884168
33MP0004885_abnormal_endolymph1.51816382
34MP0004233_abnormal_muscle_weight1.49882965
35MP0009046_muscle_twitch1.49585041
36MP0001968_abnormal_touch/_nociception1.45653686
37MP0000534_abnormal_ureter_morphology1.45126779
38MP0002735_abnormal_chemical_nociception1.44781287
39MP0008569_lethality_at_weaning1.40706467
40MP0009384_cardiac_valve_regurgitation1.38674050
41MP0005377_hearing/vestibular/ear_phenot1.34222915
42MP0003878_abnormal_ear_physiology1.34222915
43MP0005257_abnormal_intraocular_pressure1.33202118
44MP0002184_abnormal_innervation1.32788023
45MP0000026_abnormal_inner_ear1.30924519
46MP0000569_abnormal_digit_pigmentation1.28734519
47MP0002108_abnormal_muscle_morphology1.28388860
48MP0002557_abnormal_social/conspecific_i1.28288700
49MP0003385_abnormal_body_wall1.28174098
50MP0006276_abnormal_autonomic_nervous1.27737169
51MP0003329_amyloid_beta_deposits1.25652262
52MP0009379_abnormal_foot_pigmentation1.24949347
53MP0000579_abnormal_nail_morphology1.23516070
54MP0003136_yellow_coat_color1.23501130
55MP0002272_abnormal_nervous_system1.22925574
56MP0008961_abnormal_basal_metabolism1.21985505
57MP0000733_abnormal_muscle_development1.21710494
58MP0004811_abnormal_neuron_physiology1.20001639
59MP0000955_abnormal_spinal_cord1.19411705
60MP0002234_abnormal_pharynx_morphology1.19312192
61MP0001440_abnormal_grooming_behavior1.18080004
62MP0003942_abnormal_urinary_system1.16802347
63MP0003115_abnormal_respiratory_system1.16068883
64MP0005248_abnormal_Harderian_gland1.15116535
65MP0002752_abnormal_somatic_nervous1.12782558
66MP0003938_abnormal_ear_development1.11295823
67MP0002653_abnormal_ependyma_morphology1.11091032
68MP0001485_abnormal_pinna_reflex1.10923991
69MP0001177_atelectasis1.10754426
70MP0002882_abnormal_neuron_morphology1.10711445
71MP0001963_abnormal_hearing_physiology1.09433060
72MP0001502_abnormal_circadian_rhythm1.08734153
73MP0002733_abnormal_thermal_nociception1.08075080
74MP0002067_abnormal_sensory_capabilities1.06247807
75MP0001984_abnormal_olfaction1.05131498
76MP0003123_paternal_imprinting1.03463047
77MP0005508_abnormal_skeleton_morphology1.02727780
78MP0003045_fibrosis1.02690986
79MP0001348_abnormal_lacrimal_gland1.02181734
80MP0001970_abnormal_pain_threshold1.01959182
81MP0004133_heterotaxia1.01873851
82MP0000537_abnormal_urethra_morphology1.01353917
83MP0003091_abnormal_cell_migration1.00176768
84MP0002697_abnormal_eye_size0.99957978
85MP0006292_abnormal_olfactory_placode0.99932691
86MP0005646_abnormal_pituitary_gland0.99625310
87MP0002089_abnormal_postnatal_growth/wei0.99067335
88MP0009250_abnormal_appendicular_skeleto0.98148435
89MP0002152_abnormal_brain_morphology0.96760080
90MP0002090_abnormal_vision0.96696708
91MP0002736_abnormal_nociception_after0.96676287
92MP0001501_abnormal_sleep_pattern0.96275363
93MP0003634_abnormal_glial_cell0.95050939
94MP0000920_abnormal_myelination0.94591368
95MP0000428_abnormal_craniofacial_morphol0.94386093
96MP0003879_abnormal_hair_cell0.93337726
97MP0003787_abnormal_imprinting0.92734608
98MP0000631_abnormal_neuroendocrine_gland0.92130206
99MP0004145_abnormal_muscle_electrophysio0.91769637
100MP0002249_abnormal_larynx_morphology0.89996417
101MP0003632_abnormal_nervous_system0.89371092
102MP0003121_genomic_imprinting0.89113134
103MP0005409_darkened_coat_color0.88651673
104MP0004134_abnormal_chest_morphology0.88585706
105MP0002066_abnormal_motor_capabilities/c0.88121327
106MP0005386_behavior/neurological_phenoty0.84744528
107MP0004924_abnormal_behavior0.84744528
108MP0003631_nervous_system_phenotype0.84591528
109MP0002896_abnormal_bone_mineralization0.84538744
110MP0001905_abnormal_dopamine_level0.84501778
111MP0005394_taste/olfaction_phenotype0.83818361
112MP0005499_abnormal_olfactory_system0.83818361
113MP0002932_abnormal_joint_morphology0.83556370
114MP0001529_abnormal_vocalization0.83375880
115MP0003119_abnormal_digestive_system0.82817661
116MP0001293_anophthalmia0.82120529
117MP0001346_abnormal_lacrimal_gland0.79046335
118MP0003633_abnormal_nervous_system0.78925737
119MP0000049_abnormal_middle_ear0.77241284
120MP0002233_abnormal_nose_morphology0.76979244
121MP0003861_abnormal_nervous_system0.76486774
122MP0003755_abnormal_palate_morphology0.76169163
123MP0002116_abnormal_craniofacial_bone0.75861789
124MP0000003_abnormal_adipose_tissue0.75677759
125MP0001943_abnormal_respiration0.75590923
126MP0005551_abnormal_eye_electrophysiolog0.73732874
127MP0003137_abnormal_impulse_conducting0.73435066
128MP0000750_abnormal_muscle_regeneration0.73329417
129MP0005645_abnormal_hypothalamus_physiol0.73062662

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.87399705
2Premature rupture of membranes (HP:0001788)3.36445340
3Shallow orbits (HP:0000586)3.24111211
4Myokymia (HP:0002411)3.17712146
5Atrophic scars (HP:0001075)2.99113964
6Fetal akinesia sequence (HP:0001989)2.97297637
7Focal motor seizures (HP:0011153)2.89879765
8Cerebral aneurysm (HP:0004944)2.77788283
9Megalencephaly (HP:0001355)2.70338851
10Bladder diverticulum (HP:0000015)2.66499439
11Focal seizures (HP:0007359)2.65583487
12Type 1 muscle fiber predominance (HP:0003803)2.65235142
13Ankle contracture (HP:0006466)2.64786189
14Aplasia involving bones of the upper limbs (HP:0009823)2.61898966
15Aplasia of the phalanges of the hand (HP:0009802)2.61898966
16Aplasia involving bones of the extremities (HP:0009825)2.61898966
17Mildly elevated creatine phosphokinase (HP:0008180)2.58108760
18Broad metatarsal (HP:0001783)2.53821581
19Abnormality of binocular vision (HP:0011514)2.51990927
20Diplopia (HP:0000651)2.51990927
21Fragile skin (HP:0001030)2.40822984
22Vitreoretinal degeneration (HP:0000655)2.38787565
23Febrile seizures (HP:0002373)2.37414003
24Increased variability in muscle fiber diameter (HP:0003557)2.36201553
25Dilatation of the ascending aorta (HP:0005111)2.33977793
26Cutaneous finger syndactyly (HP:0010554)2.33233629
27Overgrowth (HP:0001548)2.32571243
28Abnormal eating behavior (HP:0100738)2.31466046
29Aortic dissection (HP:0002647)2.30726144
30Abnormality of dentin (HP:0010299)2.29039651
31Ankyloglossia (HP:0010296)2.27883736
32Lower limb amyotrophy (HP:0007210)2.25995224
33Coronal craniosynostosis (HP:0004440)2.21968534
34Annular pancreas (HP:0001734)2.20100039
35Supranuclear gaze palsy (HP:0000605)2.15858869
36Action tremor (HP:0002345)2.15464468
37Genu recurvatum (HP:0002816)2.15064962
38Epileptic encephalopathy (HP:0200134)2.14759649
39Neoplasm of the heart (HP:0100544)2.14758893
40Atonic seizures (HP:0010819)2.14340534
41Wide anterior fontanel (HP:0000260)2.13908063
42Sleep apnea (HP:0010535)2.13585885
43Cutaneous syndactyly (HP:0012725)2.11520550
44Akinesia (HP:0002304)2.11372049
45Hypoventilation (HP:0002791)2.09413183
46Abnormality of skeletal muscle fiber size (HP:0012084)2.07842943
47Buphthalmos (HP:0000557)2.07669884
48Bowel diverticulosis (HP:0005222)2.06956627
49Slender build (HP:0001533)2.04447649
50Neonatal short-limb short stature (HP:0008921)2.02966272
51Mild short stature (HP:0003502)2.01270239
52Bronchomalacia (HP:0002780)2.00811470
53Mitral valve prolapse (HP:0001634)2.00623091
54Abnormality of the ischium (HP:0003174)2.00501339
55Narrow nasal bridge (HP:0000446)2.00103666
56Pointed chin (HP:0000307)2.00094931
57Visual hallucinations (HP:0002367)1.99546782
58Popliteal pterygium (HP:0009756)1.96425119
59Torticollis (HP:0000473)1.95573978
60Distal upper limb amyotrophy (HP:0007149)1.94550599
61Upper limb amyotrophy (HP:0009129)1.94550599
62Generalized tonic-clonic seizures (HP:0002069)1.93288498
63Abnormality of the diencephalon (HP:0010662)1.92365724
64Round ear (HP:0100830)1.92154848
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92059475
66Short 4th metacarpal (HP:0010044)1.92059475
67Abnormality of oral frenula (HP:0000190)1.90718629
68Follicular hyperkeratosis (HP:0007502)1.90189964
69Deviation of the hallux (HP:0010051)1.90058018
70Hemiplegia (HP:0002301)1.89022492
71Hyperacusis (HP:0010780)1.88753199
72Depression (HP:0000716)1.87810187
73Thin ribs (HP:0000883)1.86944722
74Spinal rigidity (HP:0003306)1.86581624
75Renal duplication (HP:0000075)1.85086287
76Insomnia (HP:0100785)1.84760078
77Limb dystonia (HP:0002451)1.83936814
78Arterial tortuosity (HP:0005116)1.83105832
79Split foot (HP:0001839)1.82961837
80Hallux valgus (HP:0001822)1.82933760
81Turricephaly (HP:0000262)1.81796655
82Hyperextensible skin (HP:0000974)1.81784788
83Morphological abnormality of the middle ear (HP:0008609)1.81552198
84Ulnar bowing (HP:0003031)1.81416358
85Hypoplastic ischia (HP:0003175)1.80824836
86Vascular tortuosity (HP:0004948)1.79953846
87Soft skin (HP:0000977)1.79648785
88Pterygium (HP:0001059)1.79139152
89Abnormality of the aortic arch (HP:0012303)1.77812918
90Hemiparesis (HP:0001269)1.77804559
91Infantile muscular hypotonia (HP:0008947)1.77305251
92Flat cornea (HP:0007720)1.76107502
93Septo-optic dysplasia (HP:0100842)1.75729507
94Neurofibrillary tangles (HP:0002185)1.75627373
95Ulnar claw (HP:0001178)1.74518302
96Cerebral inclusion bodies (HP:0100314)1.74383673
97Spastic gait (HP:0002064)1.73644280
98Enlarged penis (HP:0000040)1.73144882
99Ankle clonus (HP:0011448)1.72982023
100Striae distensae (HP:0001065)1.72973872
101Macroorchidism (HP:0000053)1.72615156
102Overriding aorta (HP:0002623)1.71425822
103Hammertoe (HP:0001765)1.70582153
104Progressive cerebellar ataxia (HP:0002073)1.70155496
105Polyphagia (HP:0002591)1.69438283
106Renovascular hypertension (HP:0100817)1.68536884
107Hypercortisolism (HP:0001578)1.67127308
108Amblyopia (HP:0000646)1.67028960
109Trigonocephaly (HP:0000243)1.64665870
110Wrist flexion contracture (HP:0001239)1.64192695
111Aqueductal stenosis (HP:0002410)1.63807635
112Hypoplasia of the iris (HP:0007676)1.63474590
113Aortic aneurysm (HP:0004942)1.63303500
114Truncal ataxia (HP:0002078)1.62435204
115Distal lower limb amyotrophy (HP:0008944)1.62402778
116Drooling (HP:0002307)1.61680364
117Scapular winging (HP:0003691)1.60820076
118Limited hip movement (HP:0008800)1.59653108
119Vertebral arch anomaly (HP:0008438)1.59648028
120Megalocornea (HP:0000485)1.59458874
121Hypoplastic nipples (HP:0002557)1.59260739
122Hepatoblastoma (HP:0002884)1.59060135
123Tracheomalacia (HP:0002779)1.58232431
124Difficulty running (HP:0009046)1.58190391
125Congenital glaucoma (HP:0001087)1.56937490
126Abnormality of the lower motor neuron (HP:0002366)1.55482741
127Abnormality of the corticospinal tract (HP:0002492)1.55409050
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54395982
129Papilledema (HP:0001085)1.54246937
130Elfin facies (HP:0004428)1.53709611
131Broad ribs (HP:0000885)1.53695225
132Alacrima (HP:0000522)1.53522755
133Mitral regurgitation (HP:0001653)1.51920043
134Genetic anticipation (HP:0003743)1.51625312
135Obstructive sleep apnea (HP:0002870)1.50903128
136Joint laxity (HP:0001388)1.50785407
137Bowed forearm bones (HP:0003956)1.50548093
138Bowing of the arm (HP:0006488)1.50548093
139Abnormality of the 4th metacarpal (HP:0010012)1.50423514
140Focal dystonia (HP:0004373)1.49483348
141Dysmetria (HP:0001310)1.47983144
142Broad long bones (HP:0005622)1.47264428
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.45220101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.50119216
2NTRK33.06083773
3PRKD32.79495509
4TRIB32.74309864
5MAP3K92.74135309
6MARK12.47476447
7PNCK2.45710035
8MAPK152.23472450
9NTRK22.20767334
10PAK62.10691552
11DDR21.92372117
12RIPK11.89921809
13NTRK11.81412913
14LATS21.80864923
15PDGFRA1.79373862
16LMTK21.79099473
17CAMKK11.77410698
18MINK11.75561682
19MAP3K41.74970807
20KSR21.74086425
21DAPK21.73144801
22TYRO31.70480714
23KSR11.64454482
24MOS1.58451185
25LATS11.52657515
26EPHB21.44128781
27PKN21.37906436
28ICK1.32696980
29PAK31.31004796
30PHKG11.29711228
31PHKG21.29711228
32SIK21.28665537
33MAP3K21.28504621
34STK381.24505219
35CDK51.24279158
36DYRK21.23519809
37MAP3K101.15290404
38TNIK1.12116261
39MUSK1.11286814
40CDK151.07459368
41CDK181.04875540
42MARK21.04716375
43DMPK1.04250751
44PKN11.03515545
45SIK11.03377812
46CDK141.01995311
47MAPK131.01671104
48CDK191.01466014
49INSRR0.99998607
50UHMK10.99516318
51PINK10.99058756
52PRKCH0.97723458
53RET0.97462310
54EEF2K0.96885580
55BMX0.95465329
56MAP2K10.95003665
57CDK11A0.93112669
58TTN0.91389063
59CAMK2B0.89077243
60PRPF4B0.87911385
61TAOK10.87906528
62PLK20.85961310
63MAP2K70.85043770
64PTK20.84477882
65FGFR20.84318607
66CAMK1G0.84062936
67EPHA30.83992266
68ROCK10.82729100
69PTK2B0.81169363
70SGK30.78056107
71CDC42BPA0.77925628
72FER0.77752662
73ERBB20.77539514
74FGFR10.73726006
75ROCK20.73532753
76PRKCG0.69654161
77SGK2230.68324922
78SGK4940.68324922
79ALK0.66642949
80PTK60.65498366
81PDGFRB0.65365942
82DYRK1A0.65313564
83SGK20.64751671
84CAMK2A0.63583940
85MAP2K40.63387710
86BCR0.61261517
87MAP3K70.61063166
88WNK30.60170217
89PRKD20.59963596
90CAMK2G0.59431316
91EPHA20.57560021
92DYRK1B0.57170808
93STK110.56405437
94ERBB30.55240449
95MET0.55061373
96MAPKAPK50.54912424
97SCYL20.54126854
98PAK20.53774724
99PRKCZ0.53311913
100CAMK10.51464914
101RPS6KA20.50564572
102WNK40.49941402
103NEK60.49452684
104SGK10.49327272
105FYN0.49286316
106CAMK40.48496735
107DAPK10.48483583
108MTOR0.48108051
109RPS6KA30.47510900
110ILK0.47337438
111WNK10.44741468
112CSNK1G20.44197881
113FES0.42531658
114MAPK100.41753334
115CASK0.41031060
116ERBB40.40490399
117CDK30.40051835
118GRK50.39826134
119MAPK120.39821289
120PRKD10.39695464
121SRC0.39016602
122ERN10.37739845
123CAMK2D0.37639694
124ARAF0.35852633
125EPHB10.33053803

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.27983859
2Circadian entrainment_Homo sapiens_hsa047132.09303557
3Olfactory transduction_Homo sapiens_hsa047402.07974778
4GABAergic synapse_Homo sapiens_hsa047271.97537453
5Synaptic vesicle cycle_Homo sapiens_hsa047211.92333101
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83535551
7Glutamatergic synapse_Homo sapiens_hsa047241.79991649
8Salivary secretion_Homo sapiens_hsa049701.79887984
9Morphine addiction_Homo sapiens_hsa050321.79481324
10Insulin secretion_Homo sapiens_hsa049111.77748625
11Long-term potentiation_Homo sapiens_hsa047201.75599318
12Amphetamine addiction_Homo sapiens_hsa050311.73033791
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68370837
14Gastric acid secretion_Homo sapiens_hsa049711.68350016
15Cocaine addiction_Homo sapiens_hsa050301.64546469
16Dilated cardiomyopathy_Homo sapiens_hsa054141.62583268
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62379257
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61781172
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61125346
20Cholinergic synapse_Homo sapiens_hsa047251.59867044
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56118387
22Dopaminergic synapse_Homo sapiens_hsa047281.53799242
23Axon guidance_Homo sapiens_hsa043601.51039584
24Renin secretion_Homo sapiens_hsa049241.48848218
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47909777
26Gap junction_Homo sapiens_hsa045401.44764024
27Glioma_Homo sapiens_hsa052141.43466571
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42614992
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42083144
30GnRH signaling pathway_Homo sapiens_hsa049121.37079369
31Melanogenesis_Homo sapiens_hsa049161.33619824
32ECM-receptor interaction_Homo sapiens_hsa045121.30792182
33Estrogen signaling pathway_Homo sapiens_hsa049151.28847026
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25429181
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24712088
36Calcium signaling pathway_Homo sapiens_hsa040201.21732226
37cAMP signaling pathway_Homo sapiens_hsa040241.18583632
38Basal cell carcinoma_Homo sapiens_hsa052171.17720956
39Hedgehog signaling pathway_Homo sapiens_hsa043401.17281632
40Prion diseases_Homo sapiens_hsa050201.16919341
41Notch signaling pathway_Homo sapiens_hsa043301.16496849
42Long-term depression_Homo sapiens_hsa047301.14779289
43Focal adhesion_Homo sapiens_hsa045101.14218111
44Bile secretion_Homo sapiens_hsa049761.14030711
45Dorso-ventral axis formation_Homo sapiens_hsa043201.10178681
46ErbB signaling pathway_Homo sapiens_hsa040121.09888540
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08476515
48Hippo signaling pathway_Homo sapiens_hsa043901.06655431
49Serotonergic synapse_Homo sapiens_hsa047261.04334547
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02400044
51Endometrial cancer_Homo sapiens_hsa052131.02342237
52Taste transduction_Homo sapiens_hsa047421.00777902
53Proteoglycans in cancer_Homo sapiens_hsa052051.00684391
54Wnt signaling pathway_Homo sapiens_hsa043100.99458707
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.98046535
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96960742
57Type II diabetes mellitus_Homo sapiens_hsa049300.96563258
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96012716
59Nitrogen metabolism_Homo sapiens_hsa009100.94893062
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90997343
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.90394648
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89987006
63Thyroid hormone synthesis_Homo sapiens_hsa049180.89721010
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83855068
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83497802
66Rap1 signaling pathway_Homo sapiens_hsa040150.81147451
67Amoebiasis_Homo sapiens_hsa051460.80927162
68mTOR signaling pathway_Homo sapiens_hsa041500.80727499
69Protein digestion and absorption_Homo sapiens_hsa049740.80042699
70Non-small cell lung cancer_Homo sapiens_hsa052230.78121674
71Bladder cancer_Homo sapiens_hsa052190.77899003
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.77616574
73Adherens junction_Homo sapiens_hsa045200.75736480
74Colorectal cancer_Homo sapiens_hsa052100.75525637
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75433776
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74696159
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73953580
78MAPK signaling pathway_Homo sapiens_hsa040100.73351478
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73306273
80Tight junction_Homo sapiens_hsa045300.70751348
81Choline metabolism in cancer_Homo sapiens_hsa052310.70719820
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70713169
83Renal cell carcinoma_Homo sapiens_hsa052110.70251290
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70196930
85Fatty acid biosynthesis_Homo sapiens_hsa000610.70095780
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70074015
87Pancreatic secretion_Homo sapiens_hsa049720.69927222
88Chronic myeloid leukemia_Homo sapiens_hsa052200.69645277
89Circadian rhythm_Homo sapiens_hsa047100.69381384
90VEGF signaling pathway_Homo sapiens_hsa043700.66820414
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66259081
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62322329
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62305357
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62139687
95Glucagon signaling pathway_Homo sapiens_hsa049220.61903867
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.61431092
97Ras signaling pathway_Homo sapiens_hsa040140.60888275
98Oocyte meiosis_Homo sapiens_hsa041140.60704665
99Histidine metabolism_Homo sapiens_hsa003400.60019344
100Insulin signaling pathway_Homo sapiens_hsa049100.59433536
101Cardiac muscle contraction_Homo sapiens_hsa042600.58505670
102Ovarian steroidogenesis_Homo sapiens_hsa049130.58263680
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56506065
104Arginine and proline metabolism_Homo sapiens_hsa003300.56388197
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56267464
106Endocytosis_Homo sapiens_hsa041440.55982439
107MicroRNAs in cancer_Homo sapiens_hsa052060.55420282
108Phototransduction_Homo sapiens_hsa047440.54125128
109Pathways in cancer_Homo sapiens_hsa052000.52001880
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48291993
111Alcoholism_Homo sapiens_hsa050340.47868959
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45267537
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42093472
114Arginine biosynthesis_Homo sapiens_hsa002200.40070531
115Vitamin B6 metabolism_Homo sapiens_hsa007500.38281837

Most similar genes based on co-expression Upload to Enrichr

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