SORCS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.08480153
2synaptic vesicle maturation (GO:0016188)5.53080702
3neuron cell-cell adhesion (GO:0007158)5.51003429
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.37618433
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21171768
6protein localization to synapse (GO:0035418)5.15491481
7glutamate receptor signaling pathway (GO:0007215)5.04532453
8presynaptic membrane assembly (GO:0097105)4.99423368
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.97680914
10neuronal action potential propagation (GO:0019227)4.93282545
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.92896133
12postsynaptic membrane organization (GO:0001941)4.68819613
13regulation of glutamate receptor signaling pathway (GO:1900449)4.57647277
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.55005481
15presynaptic membrane organization (GO:0097090)4.53639061
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.40970740
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39205903
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.36772063
19synaptic vesicle exocytosis (GO:0016079)4.35300843
20cerebellar granule cell differentiation (GO:0021707)4.34511459
21startle response (GO:0001964)4.31111442
22neuron recognition (GO:0008038)4.28938552
23neuron-neuron synaptic transmission (GO:0007270)4.28161038
24synaptic transmission, glutamatergic (GO:0035249)4.27981198
25auditory behavior (GO:0031223)4.22442461
26cellular potassium ion homeostasis (GO:0030007)4.18476664
27sodium ion export (GO:0071436)4.16074441
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.99724361
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.98974543
30response to histamine (GO:0034776)3.98083300
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.98057502
32positive regulation of synapse assembly (GO:0051965)3.93070047
33regulation of glutamate secretion (GO:0014048)3.88016294
34dendritic spine morphogenesis (GO:0060997)3.84836145
35transmission of nerve impulse (GO:0019226)3.82718347
36L-amino acid import (GO:0043092)3.80645530
37regulation of postsynaptic membrane potential (GO:0060078)3.78811759
38behavioral fear response (GO:0001662)3.74262006
39behavioral defense response (GO:0002209)3.74262006
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71278333
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71214887
42neurotransmitter-gated ion channel clustering (GO:0072578)3.69840437
43exploration behavior (GO:0035640)3.67181843
44axonal fasciculation (GO:0007413)3.62136616
45long-term memory (GO:0007616)3.60616113
46regulation of synaptic vesicle exocytosis (GO:2000300)3.59996399
47regulation of neuronal synaptic plasticity (GO:0048168)3.57684087
48positive regulation of membrane potential (GO:0045838)3.55677389
49mechanosensory behavior (GO:0007638)3.53758963
50regulation of synapse structural plasticity (GO:0051823)3.52699625
51locomotory exploration behavior (GO:0035641)3.51209830
52cell communication by electrical coupling (GO:0010644)3.49317004
53fear response (GO:0042596)3.48458906
54righting reflex (GO:0060013)3.48012490
55amino acid import (GO:0043090)3.39643888
56regulation of synaptic vesicle transport (GO:1902803)3.39016598
57long-term synaptic potentiation (GO:0060291)3.38385180
58positive regulation of dendritic spine development (GO:0060999)3.37829848
59membrane depolarization during action potential (GO:0086010)3.35326927
60positive regulation of synapse maturation (GO:0090129)3.33744905
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.31970373
62serotonin receptor signaling pathway (GO:0007210)3.30842492
63response to auditory stimulus (GO:0010996)3.30831687
64synaptic vesicle endocytosis (GO:0048488)3.30522959
65regulation of dendritic spine morphogenesis (GO:0061001)3.29870220
66positive regulation of neurotransmitter secretion (GO:0001956)3.29379734
67pyrimidine nucleobase catabolic process (GO:0006208)3.28564451
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.27812572
69neuronal ion channel clustering (GO:0045161)3.27800486
70neurotransmitter secretion (GO:0007269)3.26837255
71regulation of synapse assembly (GO:0051963)3.24337728
72cellular sodium ion homeostasis (GO:0006883)3.23477396
73layer formation in cerebral cortex (GO:0021819)3.23325052
74* learning (GO:0007612)3.22064116
75dendritic spine organization (GO:0097061)3.20821580
76regulation of synaptic plasticity (GO:0048167)3.18776320
77cerebral cortex radially oriented cell migration (GO:0021799)3.18676629
78regulation of female receptivity (GO:0045924)3.17236347
79potassium ion import (GO:0010107)3.17164998
80female mating behavior (GO:0060180)3.16581828
81axon ensheathment in central nervous system (GO:0032291)3.16095492
82central nervous system myelination (GO:0022010)3.16095492
83glutamate secretion (GO:0014047)3.15214096
84central nervous system projection neuron axonogenesis (GO:0021952)3.15008759
85regulation of neuron projection regeneration (GO:0070570)3.14405323
86regulation of axon regeneration (GO:0048679)3.14405323
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13913376
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12917099
89synapse assembly (GO:0007416)3.12859128
90membrane depolarization (GO:0051899)3.12273512
91regulation of protein kinase A signaling (GO:0010738)3.11074739
92synaptic transmission, dopaminergic (GO:0001963)3.10812096
93regulation of dendritic spine development (GO:0060998)3.10441927
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08195188
95regulation of synaptic transmission, GABAergic (GO:0032228)3.06349870
96positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06314451
97potassium ion homeostasis (GO:0055075)3.06297115
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04267793
99regulation of vesicle fusion (GO:0031338)3.03694520
100cell migration in hindbrain (GO:0021535)3.02963103
101gamma-aminobutyric acid transport (GO:0015812)3.01983435
102detection of calcium ion (GO:0005513)3.01553919
103regulation of neurotransmitter levels (GO:0001505)3.01250249
104neurotransmitter transport (GO:0006836)2.98717386
105behavioral response to cocaine (GO:0048148)2.97882721
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97720144
107dendrite morphogenesis (GO:0048813)2.96874139
108neuronal action potential (GO:0019228)2.96870349
109regulation of synapse maturation (GO:0090128)2.96826143
110regulation of voltage-gated calcium channel activity (GO:1901385)2.95944258
111adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.95477958
112intraspecies interaction between organisms (GO:0051703)2.95145977
113social behavior (GO:0035176)2.95145977
114membrane assembly (GO:0071709)2.92117416
115negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91222828
116regulation of synapse organization (GO:0050807)2.91028425
117regulation of neurotransmitter secretion (GO:0046928)2.90752631
118neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.90679512
119regulation of respiratory system process (GO:0044065)2.89076921
120neuron remodeling (GO:0016322)2.87226876
121response to cocaine (GO:0042220)2.86216412
122negative regulation of amino acid transport (GO:0051956)2.84454125
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84287038
124cell communication involved in cardiac conduction (GO:0086065)2.83531571
125adult walking behavior (GO:0007628)2.83256691
126protein localization to cilium (GO:0061512)2.83202127
127cell differentiation in hindbrain (GO:0021533)2.82909905
128associative learning (GO:0008306)2.82414604
129regulation of pigment cell differentiation (GO:0050932)2.82389189
130neuromuscular process controlling balance (GO:0050885)2.81693990
131cochlea development (GO:0090102)2.80983286
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.80379191
133dendrite development (GO:0016358)2.79403230
134central nervous system neuron axonogenesis (GO:0021955)2.78822724
135synaptic transmission (GO:0007268)2.78093245
136positive regulation of neurotransmitter transport (GO:0051590)2.77911594
137negative regulation of dendrite development (GO:2000171)2.76711382
138* learning or memory (GO:0007611)2.76405854
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75330383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.59931549
2GBX2_23144817_ChIP-Seq_PC3_Human4.34581652
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31706921
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14949641
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99430693
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.78701431
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.73011342
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67462689
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62249535
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60053634
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60053634
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.54826808
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50272274
14* TAF15_26573619_Chip-Seq_HEK293_Human2.49352989
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41669461
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.37010097
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30602692
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27468605
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19808603
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17777225
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14899809
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10515285
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08977233
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.08098823
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03883959
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01178316
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99389703
28P300_19829295_ChIP-Seq_ESCs_Human1.93211180
29IGF1R_20145208_ChIP-Seq_DFB_Human1.91801686
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91714857
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.91581882
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80635192
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.80543896
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79104604
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75326345
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.74603808
37FUS_26573619_Chip-Seq_HEK293_Human1.73527127
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72144942
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71066467
40* RARB_27405468_Chip-Seq_BRAIN_Mouse1.70680427
41ZNF274_21170338_ChIP-Seq_K562_Hela1.69393881
42AR_21572438_ChIP-Seq_LNCaP_Human1.60462148
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57870068
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57477598
45RNF2_27304074_Chip-Seq_NSC_Mouse1.56410632
46VDR_22108803_ChIP-Seq_LS180_Human1.55315065
47* DROSHA_22980978_ChIP-Seq_HELA_Human1.50697935
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47495042
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.46864231
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.41162196
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37652989
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.36867521
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35986945
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.34241238
55* AR_25329375_ChIP-Seq_VCAP_Human1.33990706
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33843096
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30362085
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28006966
59LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27506680
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27173894
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.27068978
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22532058
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22044189
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20879290
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19846421
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19652312
67ER_23166858_ChIP-Seq_MCF-7_Human1.19489724
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19205431
69AR_19668381_ChIP-Seq_PC3_Human1.18541454
70* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18279754
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.17977826
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17500057
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.16751651
74* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16255878
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15169322
76* JUN_21703547_ChIP-Seq_K562_Human1.14466838
77* TP53_18474530_ChIP-ChIP_U2OS_Human1.14135180
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14129774
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11311584
80* STAT3_23295773_ChIP-Seq_U87_Human1.10842963
81P53_22387025_ChIP-Seq_ESCs_Mouse1.09654328
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09269271
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08172725
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.07839674
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.06388451
86* TCF4_23295773_ChIP-Seq_U87_Human1.06042377
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05623177
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05404347
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.04814221
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04398576
91* KDM2B_26808549_Chip-Seq_REH_Human1.03029792
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02995378
93EWS_26573619_Chip-Seq_HEK293_Human1.00780190
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.00612782
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98884938
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98088045
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.97881118
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97547885
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97547885
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97402597
101ERG_21242973_ChIP-ChIP_JURKAT_Human0.96981024
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96137076
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95942417
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95890738
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95735160
106SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95488593
107RING1B_27294783_Chip-Seq_NPCs_Mouse0.94534295
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93706326
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.93046365
110* TP53_20018659_ChIP-ChIP_R1E_Mouse0.93044936
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92995483
112* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92678342
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.92633389
114SOX9_26525672_Chip-Seq_HEART_Mouse0.92485705
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92025028
116P300_18555785_Chip-Seq_ESCs_Mouse0.91564603
117SOX2_18555785_Chip-Seq_ESCs_Mouse0.90921421
118TAL1_26923725_Chip-Seq_HPCs_Mouse0.90371640
119* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90292120
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90148499
121* TP53_16413492_ChIP-PET_HCT116_Human0.90010141
122BCAT_22108803_ChIP-Seq_LS180_Human0.89803956
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89665828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.14262174
2MP0004859_abnormal_synaptic_plasticity4.88735602
3MP0003635_abnormal_synaptic_transmissio3.77517563
4MP0009745_abnormal_behavioral_response3.42221573
5MP0001968_abnormal_touch/_nociception3.14426793
6MP0002063_abnormal_learning/memory/cond3.07970137
7MP0002064_seizures2.95015434
8MP0004270_analgesia2.94466967
9MP0001188_hyperpigmentation2.90908326
10MP0002736_abnormal_nociception_after2.86058112
11MP0002572_abnormal_emotion/affect_behav2.77744315
12MP0006276_abnormal_autonomic_nervous2.68677374
13MP0002272_abnormal_nervous_system2.59259359
14MP0001501_abnormal_sleep_pattern2.56215583
15MP0002735_abnormal_chemical_nociception2.54028169
16MP0001486_abnormal_startle_reflex2.49153201
17MP0009046_muscle_twitch2.45576702
18MP0009379_abnormal_foot_pigmentation2.23643235
19MP0002734_abnormal_mechanical_nocicepti2.20776400
20MP0001440_abnormal_grooming_behavior2.20465122
21MP0005423_abnormal_somatic_nervous2.17815766
22MP0005409_darkened_coat_color2.11674466
23MP0002067_abnormal_sensory_capabilities2.05524372
24MP0002822_catalepsy2.00712010
25MP0001529_abnormal_vocalization1.99885925
26MP0002184_abnormal_innervation1.98260237
27MP0000778_abnormal_nervous_system1.97288086
28MP0006292_abnormal_olfactory_placode1.88735647
29MP0001970_abnormal_pain_threshold1.87548365
30MP0002733_abnormal_thermal_nociception1.84706990
31MP0002557_abnormal_social/conspecific_i1.82888195
32MP0003879_abnormal_hair_cell1.76618591
33MP0005645_abnormal_hypothalamus_physiol1.70455452
34MP0001984_abnormal_olfaction1.55432748
35MP0003121_genomic_imprinting1.53227597
36MP0003329_amyloid_beta_deposits1.52722173
37MP0002876_abnormal_thyroid_physiology1.51274020
38MP0004142_abnormal_muscle_tone1.50870519
39MP0001905_abnormal_dopamine_level1.49563327
40MP0003123_paternal_imprinting1.46986063
41MP0003136_yellow_coat_color1.44427878
42MP0004924_abnormal_behavior1.44117361
43MP0005386_behavior/neurological_phenoty1.44117361
44MP0005187_abnormal_penis_morphology1.42644854
45MP0000015_abnormal_ear_pigmentation1.40872000
46MP0008569_lethality_at_weaning1.38053536
47MP0005646_abnormal_pituitary_gland1.37024448
48MP0010386_abnormal_urinary_bladder1.33742231
49MP0002837_dystrophic_cardiac_calcinosis1.33380910
50MP0003122_maternal_imprinting1.30521487
51MP0002882_abnormal_neuron_morphology1.27701784
52MP0002066_abnormal_motor_capabilities/c1.27508211
53MP0004742_abnormal_vestibular_system1.24880634
54MP0000955_abnormal_spinal_cord1.22556933
55MP0003787_abnormal_imprinting1.22391133
56MP0001502_abnormal_circadian_rhythm1.20350051
57MP0002102_abnormal_ear_morphology1.20145937
58MP0004811_abnormal_neuron_physiology1.19654095
59MP0002909_abnormal_adrenal_gland1.12260643
60MP0005377_hearing/vestibular/ear_phenot1.11290812
61MP0003878_abnormal_ear_physiology1.11290812
62MP0003690_abnormal_glial_cell1.09635844
63MP0004145_abnormal_muscle_electrophysio1.06666473
64MP0001963_abnormal_hearing_physiology1.05367846
65MP0000631_abnormal_neuroendocrine_gland1.04858496
66MP0005248_abnormal_Harderian_gland1.03466715
67MP0005551_abnormal_eye_electrophysiolog1.03415607
68MP0005174_abnormal_tail_pigmentation1.02765229
69MP0005171_absent_coat_pigmentation1.01302400
70MP0000566_synostosis1.00180015
71MP0000579_abnormal_nail_morphology0.94274534
72MP0005394_taste/olfaction_phenotype0.94033219
73MP0005499_abnormal_olfactory_system0.94033219
74MP0002152_abnormal_brain_morphology0.93630763
75MP0000026_abnormal_inner_ear0.93622280
76MP0001986_abnormal_taste_sensitivity0.91925792
77MP0005379_endocrine/exocrine_gland_phen0.91477755
78MP0002229_neurodegeneration0.90343629
79MP0003119_abnormal_digestive_system0.90134354
80MP0002752_abnormal_somatic_nervous0.89492705
81MP0004885_abnormal_endolymph0.87090158
82MP0000534_abnormal_ureter_morphology0.86944714
83MP0003633_abnormal_nervous_system0.85979957
84MP0002638_abnormal_pupillary_reflex0.85150639
85MP0000751_myopathy0.84774454
86MP0003861_abnormal_nervous_system0.83923415
87MP0002069_abnormal_eating/drinking_beha0.83052857
88MP0001485_abnormal_pinna_reflex0.82644599
89MP0002653_abnormal_ependyma_morphology0.80241859
90MP0000569_abnormal_digit_pigmentation0.78802346
91MP0001299_abnormal_eye_distance/0.78369772
92MP0001664_abnormal_digestion0.78341703
93MP0009780_abnormal_chondrocyte_physiolo0.78045054
94MP0002163_abnormal_gland_morphology0.76114979
95MP0003631_nervous_system_phenotype0.75617847
96MP0002234_abnormal_pharynx_morphology0.74938309
97MP0005535_abnormal_body_temperature0.74513553
98MP0004133_heterotaxia0.74316963
99MP0008877_abnormal_DNA_methylation0.73696036
100MP0003938_abnormal_ear_development0.73552774
101MP0004858_abnormal_nervous_system0.70811584
102MP0000681_abnormal_thyroid_gland0.70342252
103MP0003137_abnormal_impulse_conducting0.70179153
104MP0008874_decreased_physiological_sensi0.70163812
105MP0005253_abnormal_eye_physiology0.69470983
106MP0004484_altered_response_of0.67218706
107MP0003283_abnormal_digestive_organ0.67217135
108MP0005595_abnormal_vascular_smooth0.64359091
109MP0004043_abnormal_pH_regulation0.62801656
110MP0004085_abnormal_heartbeat0.61920799
111MP0008872_abnormal_physiological_respon0.58728576
112MP0000604_amyloidosis0.57459034
113MP0010769_abnormal_survival0.56797682
114MP0000920_abnormal_myelination0.56663777
115MP0008789_abnormal_olfactory_epithelium0.55928900
116MP0004510_myositis0.55306728
117MP0008260_abnormal_autophagy0.54651983
118MP0002751_abnormal_autonomic_nervous0.53732663
119MP0006072_abnormal_retinal_apoptosis0.52714107
120MP0001177_atelectasis0.50340212
121MP0003634_abnormal_glial_cell0.49560324
122MP0003632_abnormal_nervous_system0.49356366
123MP0002095_abnormal_skin_pigmentation0.49274207

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.92044217
2Focal seizures (HP:0007359)5.59081752
3Atonic seizures (HP:0010819)5.00666717
4Febrile seizures (HP:0002373)4.96926422
5Visual hallucinations (HP:0002367)4.84812954
6Hyperventilation (HP:0002883)4.81602377
7Absence seizures (HP:0002121)4.79141286
8Epileptic encephalopathy (HP:0200134)4.67648434
9Dialeptic seizures (HP:0011146)4.55104441
10Myokymia (HP:0002411)3.78365890
11Broad-based gait (HP:0002136)3.73213698
12Limb dystonia (HP:0002451)3.52771055
13Generalized tonic-clonic seizures (HP:0002069)3.43484895
14Progressive inability to walk (HP:0002505)3.25746587
15Amblyopia (HP:0000646)3.24940647
16Gaze-evoked nystagmus (HP:0000640)3.05400063
17Progressive cerebellar ataxia (HP:0002073)3.03971685
18Excessive salivation (HP:0003781)2.96809330
19Drooling (HP:0002307)2.96809330
20Absent speech (HP:0001344)2.90745812
21Acute necrotizing encephalopathy (HP:0006965)2.81112520
22Inability to walk (HP:0002540)2.78679403
23Hemiparesis (HP:0001269)2.77304998
24Anxiety (HP:0000739)2.76875515
25Ankle clonus (HP:0011448)2.71009428
26Protruding tongue (HP:0010808)2.65711197
27Postural instability (HP:0002172)2.62197678
28Truncal ataxia (HP:0002078)2.61092667
29Cerebral inclusion bodies (HP:0100314)2.57354492
30Supranuclear gaze palsy (HP:0000605)2.49893064
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.49852883
32Absent/shortened dynein arms (HP:0200106)2.49852883
33Fair hair (HP:0002286)2.49691992
34Hemiplegia (HP:0002301)2.49210209
35Impaired vibration sensation in the lower limbs (HP:0002166)2.48038673
36Spastic gait (HP:0002064)2.47288104
37Poor eye contact (HP:0000817)2.47052803
38Abnormal mitochondria in muscle tissue (HP:0008316)2.44821217
39Mitochondrial inheritance (HP:0001427)2.44017996
40Aplasia of the phalanges of the hand (HP:0009802)2.43661932
41Aplasia involving bones of the extremities (HP:0009825)2.43661932
42Aplasia involving bones of the upper limbs (HP:0009823)2.43661932
43Hypothermia (HP:0002045)2.43395282
44Progressive macrocephaly (HP:0004481)2.42615192
45Polyphagia (HP:0002591)2.42510801
46Neurofibrillary tangles (HP:0002185)2.41801915
47Gait imbalance (HP:0002141)2.39477874
48Medial flaring of the eyebrow (HP:0010747)2.38728009
49Abnormality of the corticospinal tract (HP:0002492)2.34586686
50Intention tremor (HP:0002080)2.34037268
51Enlarged penis (HP:0000040)2.33888667
52Dysmetria (HP:0001310)2.32323456
53Esotropia (HP:0000565)2.31902482
54Agitation (HP:0000713)2.29007096
55Abnormality of binocular vision (HP:0011514)2.28800531
56Diplopia (HP:0000651)2.28800531
57Retinal dysplasia (HP:0007973)2.28574766
58Abnormal eating behavior (HP:0100738)2.27979265
59Torticollis (HP:0000473)2.27790426
60Optic disc pallor (HP:0000543)2.26776167
61Megalencephaly (HP:0001355)2.25757581
62Urinary bladder sphincter dysfunction (HP:0002839)2.24782008
63Scanning speech (HP:0002168)2.24619614
64Dysdiadochokinesis (HP:0002075)2.24592307
65Delusions (HP:0000746)2.23839347
66Depression (HP:0000716)2.23513968
67Psychosis (HP:0000709)2.21751540
68Epileptiform EEG discharges (HP:0011182)2.19980566
69Cutaneous finger syndactyly (HP:0010554)2.19153038
70Blue irides (HP:0000635)2.18477465
71Spastic tetraparesis (HP:0001285)2.18364863
72Generalized hypopigmentation of hair (HP:0011358)2.16851959
73Urinary urgency (HP:0000012)2.16640114
74Chronic otitis media (HP:0000389)2.16581384
75Abnormal hair whorl (HP:0010721)2.16200307
76Congenital primary aphakia (HP:0007707)2.15896182
77Increased hepatocellular lipid droplets (HP:0006565)2.15889904
78Abnormality of salivation (HP:0100755)2.13871330
79Thyroid-stimulating hormone excess (HP:0002925)2.13479878
80Action tremor (HP:0002345)2.13440136
81Abnormal ciliary motility (HP:0012262)2.11805542
82Impaired social interactions (HP:0000735)2.10244284
83Abnormal social behavior (HP:0012433)2.10244284
84Renal Fanconi syndrome (HP:0001994)2.06178980
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05850764
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05032189
87Abnormality of the lower motor neuron (HP:0002366)2.04747562
88Increased circulating renin level (HP:0000848)2.04015205
89Gonadotropin excess (HP:0000837)2.02343998
90Inappropriate behavior (HP:0000719)2.01698131
91Poor suck (HP:0002033)2.01079811
92Hydroureter (HP:0000072)2.00823368
93Thickened helices (HP:0000391)1.99829662
94Nephrogenic diabetes insipidus (HP:0009806)1.99491067
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.99190946
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99190946
97Generalized myoclonic seizures (HP:0002123)1.98894162
98Intellectual disability, severe (HP:0010864)1.96438184
99Testicular atrophy (HP:0000029)1.96279011
100Palpebral edema (HP:0100540)1.95010395
101Papilledema (HP:0001085)1.94465520
102Lower limb muscle weakness (HP:0007340)1.93483531
103Abnormal respiratory epithelium morphology (HP:0012253)1.93395386
104Abnormal respiratory motile cilium morphology (HP:0005938)1.93395386
105Hepatocellular necrosis (HP:0001404)1.93298516
106Heterochromia iridis (HP:0001100)1.93228941
107Acute encephalopathy (HP:0006846)1.91118036
108Fetal akinesia sequence (HP:0001989)1.90486722
109Akinesia (HP:0002304)1.90413434
110Split foot (HP:0001839)1.90253334
111Status epilepticus (HP:0002133)1.89586501
112Mutism (HP:0002300)1.89224877
113EEG with generalized epileptiform discharges (HP:0011198)1.88196277
114Spastic tetraplegia (HP:0002510)1.88066534
115Amyotrophic lateral sclerosis (HP:0007354)1.87859103
116Obstructive sleep apnea (HP:0002870)1.85275274
117Increased CSF lactate (HP:0002490)1.84510239
118Cortical visual impairment (HP:0100704)1.83667520
119Impaired smooth pursuit (HP:0007772)1.83061756
120Morphological abnormality of the pyramidal tract (HP:0002062)1.82885416
121Peripheral hypomyelination (HP:0007182)1.82318528
122Turricephaly (HP:0000262)1.81748580
123Exotropia (HP:0000577)1.78921556
124Stereotypic behavior (HP:0000733)1.78860264
125Cutaneous syndactyly (HP:0012725)1.77792181
126Hypoplasia of the corpus callosum (HP:0002079)1.77111689
127Apathy (HP:0000741)1.76477821
1283-Methylglutaconic aciduria (HP:0003535)1.76445826
129Hypsarrhythmia (HP:0002521)1.74542325
130Prolonged QT interval (HP:0001657)1.74391194
131Nonprogressive disorder (HP:0003680)1.72944067
132Sleep apnea (HP:0010535)1.72223469
133Genital tract atresia (HP:0001827)1.70921131
134Decreased circulating renin level (HP:0003351)1.69856291
135Type II lissencephaly (HP:0007260)1.69624648
136Aplasia/Hypoplasia of the lens (HP:0008063)1.69440075
137Vaginal atresia (HP:0000148)1.69299972
138Bradykinesia (HP:0002067)1.69229481
139Genetic anticipation (HP:0003743)1.68905557
140Abnormal respiratory motile cilium physiology (HP:0012261)1.68679210
141Nuclear cataract (HP:0100018)1.68669247
142Clonus (HP:0002169)1.68299610
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68152797
144Syncope (HP:0001279)1.67374582
145Impaired vibratory sensation (HP:0002495)1.66429071
146Macroorchidism (HP:0000053)1.63911439
147CNS hypomyelination (HP:0003429)1.62851146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.57207885
2NTRK34.36938039
3CASK4.24147347
4RIPK43.75351882
5MAP3K123.46382014
6TNIK3.42964824
7MAP2K73.31115578
8MAP3K42.50436344
9BMPR22.16591502
10MINK12.12630259
11FES2.08271701
12MARK12.07313892
13PNCK2.05127241
14MUSK1.96382375
15PLK21.84488164
16MAP3K91.83468318
17MAP2K41.80283199
18GRK51.70158953
19NTRK21.66642614
20MAPK131.62471466
21INSRR1.58445487
22NME11.54415249
23EPHB11.53105923
24CDK191.48276246
25PRPF4B1.41795186
26SIK21.41550542
27LATS21.41502440
28DAPK11.31542428
29ARAF1.29961798
30TYRO31.29864786
31GRK71.29656812
32PRKD31.28450950
33SIK31.27796668
34CAMK2A1.27733417
35CAMK2B1.27653402
36KSR11.19184464
37CDK51.17951331
38DAPK21.17911958
39PTK2B1.11051990
40FGR1.08178850
41UHMK11.03145414
42STK161.02321556
43PRKCG1.00488576
44FER0.97902920
45ADRBK20.95190327
46MKNK20.92155429
47NTRK10.91613955
48MAP3K130.88081201
49ICK0.86608589
50CAMK40.85417867
51DYRK1A0.85139635
52CAMKK20.84162207
53CAMK10.83854814
54BCR0.81665048
55SGK30.78484182
56PRKCE0.77468542
57WNK30.74106604
58OXSR10.73817489
59PAK60.73561664
60CAMK2D0.72369640
61FRK0.71811981
62PLK40.70920094
63PRKCH0.70607513
64MAP4K20.69948702
65PAK30.69091183
66EPHA30.68480834
67FGFR20.68311506
68YES10.64060980
69RAF10.62293448
70BRAF0.59037884
71CDK140.58854249
72CSNK1G20.58379872
73KSR20.58137439
74CDK180.56385963
75GRK60.56370758
76ADRBK10.55545942
77TNK20.54703933
78CAMK2G0.53893564
79AKT30.53498244
80PDK10.51923874
81CAMK1G0.50608610
82CDK30.49561848
83CDK150.49473821
84MAP3K60.49208283
85TLK10.49152480
86SYK0.48251071
87BMPR1B0.48006469
88RPS6KA30.47594275
89RET0.46972200
90SGK10.46848949
91TRIM280.46410975
92PRKD20.46066910
93STK380.45854928
94STK110.45676663
95CDK11A0.44992321
96PRKACA0.44366018
97CAMKK10.43109691
98PINK10.41761169
99CDK80.41559617
100DMPK0.41308923
101WNK10.39631319
102PKN10.39570448
103PKN20.37929952
104MAPK40.37529082
105ROCK20.37128528
106FYN0.37113488
107MAP3K10.33993034
108CCNB10.33519615
109MARK20.32445605
110PRKG10.32128866
111MAPK120.31898844
112CSNK1E0.31388269
113DYRK20.30420133
114SGK2230.30111876
115SGK4940.30111876
116CSNK1G30.29295303
117NEK60.29249584
118PRKCZ0.29193483
119PRKCA0.29078740
120SGK20.27987892
121PRKCQ0.27935222
122MOS0.27331411
123MAPK80.27178530
124RPS6KA20.27028043
125GSK3B0.25745978
126PRKCB0.25634788
127PHKG10.24755193
128PHKG20.24755193
129MAPK100.23447855
130CSNK1A10.23233143

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.87949129
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.16125244
3Glutamatergic synapse_Homo sapiens_hsa047242.78249003
4Long-term potentiation_Homo sapiens_hsa047202.76280730
5Morphine addiction_Homo sapiens_hsa050322.74796612
6Synaptic vesicle cycle_Homo sapiens_hsa047212.74606159
7GABAergic synapse_Homo sapiens_hsa047272.72932057
8Circadian entrainment_Homo sapiens_hsa047132.63078556
9Amphetamine addiction_Homo sapiens_hsa050312.46971546
10Taste transduction_Homo sapiens_hsa047422.43853768
11Collecting duct acid secretion_Homo sapiens_hsa049662.29592440
12Serotonergic synapse_Homo sapiens_hsa047262.26481688
13Olfactory transduction_Homo sapiens_hsa047402.26244434
14Oxidative phosphorylation_Homo sapiens_hsa001902.25233051
15Salivary secretion_Homo sapiens_hsa049702.17587773
16Dopaminergic synapse_Homo sapiens_hsa047282.12164847
17Long-term depression_Homo sapiens_hsa047302.03453699
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87900715
19Calcium signaling pathway_Homo sapiens_hsa040201.85299054
20Renin secretion_Homo sapiens_hsa049241.81613428
21Alzheimers disease_Homo sapiens_hsa050101.79699645
22Phototransduction_Homo sapiens_hsa047441.79399990
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63904717
24Insulin secretion_Homo sapiens_hsa049111.62805668
25Cholinergic synapse_Homo sapiens_hsa047251.62257421
26Gastric acid secretion_Homo sapiens_hsa049711.53937340
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52931864
28Oxytocin signaling pathway_Homo sapiens_hsa049211.50469887
29Parkinsons disease_Homo sapiens_hsa050121.48680497
30Cardiac muscle contraction_Homo sapiens_hsa042601.43630975
31Vibrio cholerae infection_Homo sapiens_hsa051101.38142392
32Cocaine addiction_Homo sapiens_hsa050301.34801483
33Axon guidance_Homo sapiens_hsa043601.26575065
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23494580
35GnRH signaling pathway_Homo sapiens_hsa049121.22552507
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19117846
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17547926
38cAMP signaling pathway_Homo sapiens_hsa040241.15675138
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14845500
40Huntingtons disease_Homo sapiens_hsa050161.11863916
41Gap junction_Homo sapiens_hsa045401.11522340
42Bile secretion_Homo sapiens_hsa049761.04019723
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01406030
44Melanogenesis_Homo sapiens_hsa049160.99838805
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97814002
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96273421
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94804726
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91979254
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90933040
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.87289676
51African trypanosomiasis_Homo sapiens_hsa051430.86802284
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84640672
53Nitrogen metabolism_Homo sapiens_hsa009100.83132950
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81775620
55Rheumatoid arthritis_Homo sapiens_hsa053230.80928257
56Pancreatic secretion_Homo sapiens_hsa049720.78315198
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78011321
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77729034
59Vitamin B6 metabolism_Homo sapiens_hsa007500.76686428
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74356445
61Type I diabetes mellitus_Homo sapiens_hsa049400.74085981
62Circadian rhythm_Homo sapiens_hsa047100.72249248
63Estrogen signaling pathway_Homo sapiens_hsa049150.71568577
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69011991
65ErbB signaling pathway_Homo sapiens_hsa040120.68727953
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67826815
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66081295
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64885072
69Glioma_Homo sapiens_hsa052140.62840970
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60806625
71Choline metabolism in cancer_Homo sapiens_hsa052310.59884035
72Oocyte meiosis_Homo sapiens_hsa041140.59069173
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57801620
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57248902
75Ras signaling pathway_Homo sapiens_hsa040140.56078017
76MAPK signaling pathway_Homo sapiens_hsa040100.55347693
77Wnt signaling pathway_Homo sapiens_hsa043100.52516506
78Alcoholism_Homo sapiens_hsa050340.49354560
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.49288458
80Hedgehog signaling pathway_Homo sapiens_hsa043400.47909413
81Endometrial cancer_Homo sapiens_hsa052130.47808890
82Thyroid hormone synthesis_Homo sapiens_hsa049180.47696016
83Protein digestion and absorption_Homo sapiens_hsa049740.45357600
84Hippo signaling pathway_Homo sapiens_hsa043900.43459333
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41788209
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41626831
87Phagosome_Homo sapiens_hsa041450.41239887
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40852514
89VEGF signaling pathway_Homo sapiens_hsa043700.40703228
90Protein export_Homo sapiens_hsa030600.39301560
91Fatty acid biosynthesis_Homo sapiens_hsa000610.38201702
92Butanoate metabolism_Homo sapiens_hsa006500.37843741
93Type II diabetes mellitus_Homo sapiens_hsa049300.37745254
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.36306565
95Dilated cardiomyopathy_Homo sapiens_hsa054140.36015148
96Rap1 signaling pathway_Homo sapiens_hsa040150.35356172
97Inositol phosphate metabolism_Homo sapiens_hsa005620.34176808
98Melanoma_Homo sapiens_hsa052180.30817899
99Renal cell carcinoma_Homo sapiens_hsa052110.28523415
100Regulation of autophagy_Homo sapiens_hsa041400.26873444
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25718548
102Ovarian steroidogenesis_Homo sapiens_hsa049130.25641848
103Basal cell carcinoma_Homo sapiens_hsa052170.24648891
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24566648
105Tight junction_Homo sapiens_hsa045300.24524249
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24045733
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24004191
108mTOR signaling pathway_Homo sapiens_hsa041500.23412549
109Sphingolipid metabolism_Homo sapiens_hsa006000.22894290
110Glucagon signaling pathway_Homo sapiens_hsa049220.22617074
111Dorso-ventral axis formation_Homo sapiens_hsa043200.22333871
112Mineral absorption_Homo sapiens_hsa049780.20509154
113Endocytosis_Homo sapiens_hsa041440.20399942
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20323931
115Chemokine signaling pathway_Homo sapiens_hsa040620.18602980
116Salmonella infection_Homo sapiens_hsa051320.17304075
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17070714
118Ether lipid metabolism_Homo sapiens_hsa005650.16637038
119Prion diseases_Homo sapiens_hsa050200.16241747
120Tuberculosis_Homo sapiens_hsa051520.16111628
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.15775708
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12011768
123Autoimmune thyroid disease_Homo sapiens_hsa053200.09800170

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