SORD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.86880039
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.86880039
3L-phenylalanine metabolic process (GO:0006558)6.66766651
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.66766651
5aromatic amino acid family catabolic process (GO:0009074)6.35295367
6indole-containing compound catabolic process (GO:0042436)5.89658360
7indolalkylamine catabolic process (GO:0046218)5.89658360
8tryptophan catabolic process (GO:0006569)5.89658360
9glyoxylate metabolic process (GO:0046487)5.69687296
10cysteine metabolic process (GO:0006534)5.61449085
11kynurenine metabolic process (GO:0070189)5.61373935
12tryptophan metabolic process (GO:0006568)5.54091699
13serine family amino acid catabolic process (GO:0009071)5.46047021
14epoxygenase P450 pathway (GO:0019373)5.36779455
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30604578
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.29711801
17bile acid biosynthetic process (GO:0006699)5.29414738
18urea cycle (GO:0000050)5.27737113
19urea metabolic process (GO:0019627)5.27737113
20sulfur amino acid catabolic process (GO:0000098)5.22290272
21amino-acid betaine metabolic process (GO:0006577)5.15893252
22lysine metabolic process (GO:0006553)5.14277705
23lysine catabolic process (GO:0006554)5.14277705
24homocysteine metabolic process (GO:0050667)5.08643682
25alpha-linolenic acid metabolic process (GO:0036109)5.02764779
26omega-hydroxylase P450 pathway (GO:0097267)4.94247253
27nitrogen cycle metabolic process (GO:0071941)4.88630546
28L-serine metabolic process (GO:0006563)4.77868703
29aromatic amino acid family metabolic process (GO:0009072)4.77634009
30glycine metabolic process (GO:0006544)4.68272128
31high-density lipoprotein particle remodeling (GO:0034375)4.62215174
32serine family amino acid metabolic process (GO:0009069)4.59647597
33negative regulation of fibrinolysis (GO:0051918)4.57231666
34bile acid metabolic process (GO:0008206)4.54971484
35alpha-amino acid catabolic process (GO:1901606)4.53197671
36complement activation, alternative pathway (GO:0006957)4.52688529
37regulation of protein activation cascade (GO:2000257)4.49542838
38urate metabolic process (GO:0046415)4.46058054
39protein carboxylation (GO:0018214)4.43595583
40peptidyl-glutamic acid carboxylation (GO:0017187)4.43595583
41drug transmembrane transport (GO:0006855)4.40251658
42serine family amino acid biosynthetic process (GO:0009070)4.37040078
43regulation of triglyceride catabolic process (GO:0010896)4.34693035
44fibrinolysis (GO:0042730)4.34580163
45regulation of fibrinolysis (GO:0051917)4.34451466
46proline metabolic process (GO:0006560)4.32927624
47ethanol metabolic process (GO:0006067)4.29514769
48cellular amino acid catabolic process (GO:0009063)4.22905179
49regulation of complement activation (GO:0030449)4.22748134
50drug catabolic process (GO:0042737)4.19750720
51tyrosine metabolic process (GO:0006570)4.18142903
52negative regulation of sterol transport (GO:0032372)4.14196033
53negative regulation of cholesterol transport (GO:0032375)4.14196033
54proline biosynthetic process (GO:0006561)4.12605622
55blood coagulation, intrinsic pathway (GO:0007597)4.11067010
56indolalkylamine metabolic process (GO:0006586)4.10855450
57cellular ketone body metabolic process (GO:0046950)4.08600319
58regulation of cholesterol esterification (GO:0010872)4.06074244
59amine catabolic process (GO:0009310)4.04668885
60cellular biogenic amine catabolic process (GO:0042402)4.04668885
61carnitine metabolic process (GO:0009437)4.03169222
62very-low-density lipoprotein particle assembly (GO:0034379)4.02313400
63benzene-containing compound metabolic process (GO:0042537)3.98982014
64reverse cholesterol transport (GO:0043691)3.98593735
65plasma lipoprotein particle remodeling (GO:0034369)3.96624261
66protein-lipid complex remodeling (GO:0034368)3.96624261
67macromolecular complex remodeling (GO:0034367)3.96624261
68bile acid and bile salt transport (GO:0015721)3.95012842
69triglyceride homeostasis (GO:0070328)3.92717309
70acylglycerol homeostasis (GO:0055090)3.92717309
71cellular modified amino acid catabolic process (GO:0042219)3.92296940
72aspartate family amino acid catabolic process (GO:0009068)3.89152142
73coenzyme catabolic process (GO:0009109)3.88283165
74organic cation transport (GO:0015695)3.86523762
75ethanol oxidation (GO:0006069)3.86334414
76drug transport (GO:0015893)3.85583286
77glutamate metabolic process (GO:0006536)3.82763352
78carboxylic acid catabolic process (GO:0046395)3.81969994
79organic acid catabolic process (GO:0016054)3.81969994
80cellular glucuronidation (GO:0052695)3.81859071
81short-chain fatty acid metabolic process (GO:0046459)3.76787739
82exogenous drug catabolic process (GO:0042738)3.76574910
832-oxoglutarate metabolic process (GO:0006103)3.75103222
84arginine metabolic process (GO:0006525)3.69662662
85plasma lipoprotein particle clearance (GO:0034381)3.67705981
86fatty acid beta-oxidation (GO:0006635)3.66879599
87phospholipid efflux (GO:0033700)3.66150814
88acetyl-CoA metabolic process (GO:0006084)3.65341118
89regulation of plasminogen activation (GO:0010755)3.65011766
90imidazole-containing compound metabolic process (GO:0052803)3.64646175
91biotin metabolic process (GO:0006768)3.60789360
92fatty acid oxidation (GO:0019395)3.60259386
93monocarboxylic acid catabolic process (GO:0072329)3.54964922
94aldehyde catabolic process (GO:0046185)3.54570238
95fatty acid catabolic process (GO:0009062)3.54311861
96heme transport (GO:0015886)3.53450604
97response to mercury ion (GO:0046689)3.53126759
98lipid oxidation (GO:0034440)3.52707004
99positive regulation of triglyceride lipase activity (GO:0061365)3.52319776
100positive regulation of lipoprotein lipase activity (GO:0051006)3.52319776
101ketone body metabolic process (GO:1902224)3.51764306
102oxidative demethylation (GO:0070989)3.50344532
103valine metabolic process (GO:0006573)3.48393429
104phenylpropanoid metabolic process (GO:0009698)3.46395764
105regulation of bile acid biosynthetic process (GO:0070857)3.44291386
106cholesterol homeostasis (GO:0042632)3.43312844
107cofactor catabolic process (GO:0051187)3.42068602
108pyridine nucleotide biosynthetic process (GO:0019363)3.41672938
109nicotinamide nucleotide biosynthetic process (GO:0019359)3.41672938
110uronic acid metabolic process (GO:0006063)3.40748534
111glucuronate metabolic process (GO:0019585)3.40748534
112drug metabolic process (GO:0017144)3.39472039
113sterol homeostasis (GO:0055092)3.38741187
114primary alcohol catabolic process (GO:0034310)3.35206423
115folic acid-containing compound metabolic process (GO:0006760)3.31687721
116glutamine family amino acid biosynthetic process (GO:0009084)3.29951355
117tetrahydrofolate metabolic process (GO:0046653)3.27713766
118oxaloacetate metabolic process (GO:0006107)3.27268365
119plasma lipoprotein particle assembly (GO:0034377)3.19868492
120regulation of translational fidelity (GO:0006450)3.11105111
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.08482913
122negative regulation of hemostasis (GO:1900047)3.06322356
123negative regulation of blood coagulation (GO:0030195)3.06322356
124cholesterol efflux (GO:0033344)3.04749248
125cellular aldehyde metabolic process (GO:0006081)3.00145783
126S-adenosylmethionine metabolic process (GO:0046500)2.98914549
127branched-chain amino acid catabolic process (GO:0009083)2.98715646
128negative regulation of lipase activity (GO:0060192)2.96485944
129intestinal cholesterol absorption (GO:0030299)2.95459120
130NADH metabolic process (GO:0006734)2.94551301
131folic acid metabolic process (GO:0046655)2.94543745
132alpha-amino acid biosynthetic process (GO:1901607)2.94145134
133pteridine-containing compound metabolic process (GO:0042558)2.91186162
134negative regulation of fatty acid biosynthetic process (GO:0045717)2.88309577
135protein activation cascade (GO:0072376)2.87071401
136regulation of cholesterol biosynthetic process (GO:0045540)2.85471709
137positive regulation of cellular amine metabolic process (GO:0033240)2.83545958
138negative regulation of coagulation (GO:0050819)2.78736734
139primary alcohol metabolic process (GO:0034308)2.78643444
140negative regulation of wound healing (GO:0061045)2.76629431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.30825653
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.42586230
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.15012048
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.59966423
5E2F7_22180533_ChIP-Seq_HELA_Human4.77901732
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.60927961
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56778077
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37008107
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.82982107
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.41838410
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97269499
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.95747105
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63259921
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29940025
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28141048
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.25495155
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18738242
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17611015
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17044722
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4198535
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97209382
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94197840
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91716604
24ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88853519
25CHD1_26751641_Chip-Seq_LNCaP_Human1.81499428
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79067864
27XRN2_22483619_ChIP-Seq_HELA_Human1.78489066
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76460847
29* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74857721
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67014844
31DCP1A_22483619_ChIP-Seq_HELA_Human1.62465606
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55919107
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54044067
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51163053
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.48282330
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.43622906
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43096890
38ZNF263_19887448_ChIP-Seq_K562_Human1.39544264
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37361622
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35732908
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34746536
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33134949
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.33013655
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31932413
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.29677032
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28143360
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27758555
48GATA6_25053715_ChIP-Seq_YYC3_Human1.27218260
49KDM5A_27292631_Chip-Seq_BREAST_Human1.25998547
50GABP_19822575_ChIP-Seq_HepG2_Human1.25643704
51TTF2_22483619_ChIP-Seq_HELA_Human1.25424922
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23050728
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21970533
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21359283
55HTT_18923047_ChIP-ChIP_STHdh_Human1.18827973
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18290470
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17153905
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16685875
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16345935
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15407454
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15148750
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14805192
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.12635994
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.12536383
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11558888
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10560696
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.09974315
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08151387
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.05615408
70RACK7_27058665_Chip-Seq_MCF-7_Human1.05391412
71* SOX17_20123909_ChIP-Seq_XEN_Mouse1.04648950
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02831999
73AR_21909140_ChIP-Seq_LNCAP_Human1.02619062
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00800640
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99821965
76NANOG_21062744_ChIP-ChIP_HESCs_Human0.99497145
77GATA1_22025678_ChIP-Seq_K562_Human0.98744473
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97237521
79GATA4_25053715_ChIP-Seq_YYC3_Human0.97091399
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96746508
81STAT1_17558387_ChIP-Seq_HELA_Human0.96505857
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96319378
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93409275
84MYC_22102868_ChIP-Seq_BL_Human0.93320955
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91836910
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91473311
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91366954
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91206918
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90981162
90TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90057140
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89895405
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89636493
93RARB_24833708_ChIP-Seq_LIVER_Mouse0.89431625
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89079631
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88331727
96CLOCK_20551151_ChIP-Seq_293T_Human0.88055794
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.87328647
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87277312
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86917767
100ATF3_27146783_Chip-Seq_COLON_Human0.86159162
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86042352
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85715811
103FOXP3_21729870_ChIP-Seq_TREG_Human0.85624464
104CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85122695
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83543309
106P53_21459846_ChIP-Seq_SAOS-2_Human0.83419567
107SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81508110
108GATA3_21867929_ChIP-Seq_CD8_Mouse0.80288294
109ERG_20517297_ChIP-Seq_VCAP_Human0.77576399
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.77446428
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77429772
112* TET1_21451524_ChIP-Seq_MESCs_Mouse0.75901075
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75682540
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74585308
115BCOR_27268052_Chip-Seq_Bcells_Human0.74309496
116FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73797361
117JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73390674
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73058704
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72003923
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71339136
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.71065235
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70582096
123CEBPB_22108803_ChIP-Seq_LS180_Human0.70470904
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.69905357
125AR_20517297_ChIP-Seq_VCAP_Human0.69245415
126SPI1_26923725_Chip-Seq_HPCs_Mouse0.68099583
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66276084
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66080277
129CREB1_15753290_ChIP-ChIP_HEK293T_Human0.66035882
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65944308
131* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.65623532
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.65275544
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64040652
134RARG_19884340_ChIP-ChIP_MEFs_Mouse0.63038049
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62628698
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62233651
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62181667
138MYC_19915707_ChIP-ChIP_AK7_Human0.62132507
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61654444
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61639392
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.61499495
142BCL6_27268052_Chip-Seq_Bcells_Human0.60836529
143* RAC3_21632823_ChIP-Seq_H3396_Human0.60647797
144* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60531763
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.60375695
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.59215098
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.59109731
148SOX2_21211035_ChIP-Seq_LN229_Human0.58562416
149TAF2_19829295_ChIP-Seq_ESCs_Human0.58460257
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.58098594
151FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.57610536
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56548764
153FLI1_21867929_ChIP-Seq_CD8_Mouse0.55934417
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.55263205
155NANOG_20526341_ChIP-Seq_ESCs_Human0.54368741
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.54231142
157GATA3_21867929_ChIP-Seq_TH1_Mouse0.54159178
158MYC_18358816_ChIP-ChIP_MESCs_Mouse0.54108692
159P300_27268052_Chip-Seq_Bcells_Human0.54058873
160CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.53982398
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.53784590
162PHF8_20622854_ChIP-Seq_HELA_Human0.53246490
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53025401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.65285580
2MP0005360_urolithiasis7.34263094
3MP0005085_abnormal_gallbladder_physiolo5.79079934
4MP0005365_abnormal_bile_salt5.68719301
5MP0008875_abnormal_xenobiotic_pharmacok4.94149228
6MP0003806_abnormal_nucleotide_metabolis3.96014040
7MP0003252_abnormal_bile_duct3.49122876
8MP0009840_abnormal_foam_cell3.29817956
9MP0010329_abnormal_lipoprotein_level3.20994271
10MP0005332_abnormal_amino_acid3.19525618
11MP0003195_calcinosis2.98623014
12MP0004019_abnormal_vitamin_homeostasis2.80075128
13MP0005410_abnormal_fertilization2.73118659
14MP0010234_abnormal_vibrissa_follicle2.58452078
15MP0005083_abnormal_biliary_tract2.54532493
16MP0001666_abnormal_nutrient_absorption2.43699286
17MP0003693_abnormal_embryo_hatching2.26010622
18MP0003191_abnormal_cellular_cholesterol2.10794827
19MP0000609_abnormal_liver_physiology2.04750196
20MP0003941_abnormal_skin_development2.01302736
21MP0005319_abnormal_enzyme/_coenzyme1.97578958
22MP0002118_abnormal_lipid_homeostasis1.96358575
23MP0002138_abnormal_hepatobiliary_system1.95914025
24MP0004957_abnormal_blastocyst_morpholog1.91135078
25MP0003111_abnormal_nucleus_morphology1.83915504
26MP0010094_abnormal_chromosome_stability1.76873034
27MP0009643_abnormal_urine_homeostasis1.75246001
28MP0005451_abnormal_body_composition1.68442009
29MP0000537_abnormal_urethra_morphology1.66509484
30* MP0001764_abnormal_homeostasis1.64912199
31MP0000566_synostosis1.64229422
32MP0003186_abnormal_redox_activity1.62167012
33MP0003868_abnormal_feces_composition1.60154361
34MP0005584_abnormal_enzyme/coenzyme_acti1.54285047
35MP0004858_abnormal_nervous_system1.53660887
36MP0005670_abnormal_white_adipose1.53501105
37MP0005636_abnormal_mineral_homeostasis1.48486302
38MP0003077_abnormal_cell_cycle1.44926556
39MP0003315_abnormal_perineum_morphology1.44808983
40MP0001730_embryonic_growth_arrest1.43840830
41MP0003656_abnormal_erythrocyte_physiolo1.38333303
42MP0009697_abnormal_copulation1.34454331
43MP0006036_abnormal_mitochondrial_physio1.30984646
44MP0003011_delayed_dark_adaptation1.24449545
45MP0005647_abnormal_sex_gland1.23839036
46MP0000598_abnormal_liver_morphology1.21876436
47MP0008932_abnormal_embryonic_tissue1.16161652
48MP0003123_paternal_imprinting1.15920424
49MP0001756_abnormal_urination1.15759008
50MP0008007_abnormal_cellular_replicative1.15022941
51MP0005187_abnormal_penis_morphology1.12238399
52MP0005501_abnormal_skin_physiology1.11138242
53MP0008058_abnormal_DNA_repair1.09478127
54MP0004043_abnormal_pH_regulation1.07005694
55MP0002009_preneoplasia1.04562057
56MP0004233_abnormal_muscle_weight0.98648262
57MP0008469_abnormal_protein_level0.96399031
58MP0009764_decreased_sensitivity_to0.95092496
59MP0002876_abnormal_thyroid_physiology0.92745673
60MP0001929_abnormal_gametogenesis0.91906100
61MP0009642_abnormal_blood_homeostasis0.91831293
62MP0003718_maternal_effect0.91658317
63MP0002136_abnormal_kidney_physiology0.91490492
64MP0005084_abnormal_gallbladder_morpholo0.90392044
65MP0003698_abnormal_male_reproductive0.89953460
66MP0001765_abnormal_ion_homeostasis0.89763901
67MP0001661_extended_life_span0.89252632
68MP0005380_embryogenesis_phenotype0.88992852
69MP0001672_abnormal_embryogenesis/_devel0.88992852
70MP0006035_abnormal_mitochondrial_morpho0.88704734
71MP0009763_increased_sensitivity_to0.87729234
72MP0002249_abnormal_larynx_morphology0.87078938
73MP0000350_abnormal_cell_proliferation0.85664057
74MP0004185_abnormal_adipocyte_glucose0.85549222
75MP0001915_intracranial_hemorrhage0.84225330
76MP0008057_abnormal_DNA_replication0.83631983
77MP0003984_embryonic_growth_retardation0.82813522
78MP0002080_prenatal_lethality0.82728656
79MP0002166_altered_tumor_susceptibility0.81216717
80MP0002088_abnormal_embryonic_growth/wei0.80281278
81MP0001697_abnormal_embryo_size0.78652582
82MP0000604_amyloidosis0.77007625
83MP0002697_abnormal_eye_size0.75850821
84MP0002090_abnormal_vision0.75558326
85MP0001881_abnormal_mammary_gland0.75172056
86MP0005408_hypopigmentation0.74776479
87MP0003705_abnormal_hypodermis_morpholog0.73725014
88MP0005058_abnormal_lysosome_morphology0.71579752
89MP0002089_abnormal_postnatal_growth/wei0.71443526
90MP0005076_abnormal_cell_differentiation0.71081241
91MP0010352_gastrointestinal_tract_polyps0.70944926
92MP0000681_abnormal_thyroid_gland0.70163874
93MP0002086_abnormal_extraembryonic_tissu0.70117672
94* MP0005376_homeostasis/metabolism_phenot0.69394446
95MP0003566_abnormal_cell_adhesion0.69065236
96MP0002971_abnormal_brown_adipose0.68903723
97MP0004130_abnormal_muscle_cell0.68298695
98MP0009765_abnormal_xenobiotic_induced0.67994009
99MP0005220_abnormal_exocrine_pancreas0.67361650
100MP0005395_other_phenotype0.67156754
101MP0005266_abnormal_metabolism0.66540195
102MP0002078_abnormal_glucose_homeostasis0.66162279
103MP0005535_abnormal_body_temperature0.65111376
104MP0001216_abnormal_epidermal_layer0.64982340
105MP0005666_abnormal_adipose_tissue0.63505885
106MP0002084_abnormal_developmental_patter0.63254934
107MP0005334_abnormal_fat_pad0.61688203
108MP0003453_abnormal_keratinocyte_physiol0.60172239
109MP0002161_abnormal_fertility/fecundity0.60061902
110MP0000627_abnormal_mammary_gland0.59905036
111MP0009703_decreased_birth_body0.59810267
112MP0000467_abnormal_esophagus_morphology0.59717343
113MP0002085_abnormal_embryonic_tissue0.58992898
114MP0003646_muscle_fatigue0.58961182
115MP0010368_abnormal_lymphatic_system0.58949954
116MP0004197_abnormal_fetal_growth/weight/0.57303392
117MP0002111_abnormal_tail_morphology0.57182028
118MP0005464_abnormal_platelet_physiology0.55474091
119MP0002098_abnormal_vibrissa_morphology0.55008404
120MP0002254_reproductive_system_inflammat0.52053085
121MP0004147_increased_porphyrin_level0.51675855
122MP0008260_abnormal_autophagy0.51497824
123MP0002132_abnormal_respiratory_system0.48135500
124MP0001145_abnormal_male_reproductive0.45683529
125MP0003638_abnormal_response/metabolism_0.45085302
126MP0002928_abnormal_bile_duct0.44448356
127MP0002210_abnormal_sex_determination0.44029704
128MP0000653_abnormal_sex_gland0.43148136
129MP0004264_abnormal_extraembryonic_tissu0.41864428
130MP0003953_abnormal_hormone_level0.41621979
131MP0009115_abnormal_fat_cell0.41601027
132MP0009672_abnormal_birth_weight0.41444214
133MP0003329_amyloid_beta_deposits0.41346681
134MP0000230_abnormal_systemic_arterial0.40917079
135MP0002135_abnormal_kidney_morphology0.40903095
136MP0004782_abnormal_surfactant_physiolog0.40608473
137MP0008873_increased_physiological_sensi0.39742042
138MP0003878_abnormal_ear_physiology0.36792137
139MP0005377_hearing/vestibular/ear_phenot0.36792137
140MP0001853_heart_inflammation0.36303730
141MP0009053_abnormal_anal_canal0.36043464
142MP0005075_abnormal_melanosome_morpholog0.35974722
143MP0005448_abnormal_energy_balance0.35244224
144MP0002796_impaired_skin_barrier0.34985896
145MP0002269_muscular_atrophy0.34795965
146MP0002168_other_aberrant_phenotype0.34785579
147MP0003724_increased_susceptibility_to0.34498044
148MP0000358_abnormal_cell_content/0.34201515
149MP0001845_abnormal_inflammatory_respons0.33850506
150MP0002970_abnormal_white_adipose0.31716372
151MP0008872_abnormal_physiological_respon0.30537119

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46590161
2Intrahepatic cholestasis (HP:0001406)6.02937423
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.81729732
4Deep venous thrombosis (HP:0002625)5.76177600
5Xanthomatosis (HP:0000991)5.50990143
6Hypobetalipoproteinemia (HP:0003563)5.31366870
7Prolonged partial thromboplastin time (HP:0003645)5.28888760
8Hyperglycinuria (HP:0003108)5.05100964
9Hyperglycinemia (HP:0002154)4.92129246
10Hyperlipoproteinemia (HP:0010980)4.79763430
11Abnormality of glycine metabolism (HP:0010895)4.65549094
12Abnormality of serine family amino acid metabolism (HP:0010894)4.65549094
13Hyperammonemia (HP:0001987)4.60464976
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39250257
15Ketosis (HP:0001946)4.27706552
16Complement deficiency (HP:0004431)4.24210941
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12528446
18Hypolipoproteinemia (HP:0010981)4.12077901
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.08718280
20Gout (HP:0001997)3.99205544
21Abnormality of fatty-acid metabolism (HP:0004359)3.85981874
22Joint hemorrhage (HP:0005261)3.82830906
23Abnormality of methionine metabolism (HP:0010901)3.75169610
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73613111
25Hypoalphalipoproteinemia (HP:0003233)3.69209544
26Abnormality of pyrimidine metabolism (HP:0004353)3.64909606
27Epidermoid cyst (HP:0200040)3.62928469
28Fat malabsorption (HP:0002630)3.52241716
29Abnormality of serum amino acid levels (HP:0003112)3.47629817
30Hypoglycemic coma (HP:0001325)3.45493269
31Abnormality of nucleobase metabolism (HP:0010932)3.40767845
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38919915
33Abnormality of the common coagulation pathway (HP:0010990)3.38841932
34Abnormality of purine metabolism (HP:0004352)3.28696965
35Hypercholesterolemia (HP:0003124)3.23975303
36Abnormality of glycolysis (HP:0004366)3.21329465
37Dicarboxylic aciduria (HP:0003215)3.13020337
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.13020337
39Abnormality of the intrinsic pathway (HP:0010989)3.11175833
40Abnormality of complement system (HP:0005339)3.07489643
41Conjugated hyperbilirubinemia (HP:0002908)3.07373382
42Hyperbilirubinemia (HP:0002904)3.05767780
43Ketoacidosis (HP:0001993)3.03403682
44Proximal tubulopathy (HP:0000114)2.99446327
45Delayed CNS myelination (HP:0002188)2.98058104
46Lethargy (HP:0001254)2.97660810
47Increased serum pyruvate (HP:0003542)2.96726021
48Metabolic acidosis (HP:0001942)2.95323419
49Vascular calcification (HP:0004934)2.83302000
50Reduced antithrombin III activity (HP:0001976)2.81894575
51Generalized aminoaciduria (HP:0002909)2.81425765
52Increased purine levels (HP:0004368)2.78308810
53Hyperuricemia (HP:0002149)2.78308810
54Bifid scrotum (HP:0000048)2.66693304
55Steatorrhea (HP:0002570)2.66412057
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62328892
57Alkalosis (HP:0001948)2.52292621
58Malnutrition (HP:0004395)2.52175275
59Hepatocellular carcinoma (HP:0001402)2.51111664
60Spontaneous abortion (HP:0005268)2.50857315
61Absent/shortened dynein arms (HP:0200106)2.47642845
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.47642845
63Irritability (HP:0000737)2.46454918
64Cardiovascular calcification (HP:0011915)2.46372746
65Neonatal hypoglycemia (HP:0001998)2.44223781
66Multiple enchondromatosis (HP:0005701)2.40544203
67Cerebral edema (HP:0002181)2.38155971
68Myocardial infarction (HP:0001658)2.37592779
69Acanthocytosis (HP:0001927)2.34848563
70Glycosuria (HP:0003076)2.31389637
71Abnormality of urine glucose concentration (HP:0011016)2.31389637
72Vomiting (HP:0002013)2.28962235
73Systemic lupus erythematosus (HP:0002725)2.25221410
74Abnormal gallbladder physiology (HP:0012438)2.22289673
75Cholecystitis (HP:0001082)2.22289673
76Nausea (HP:0002018)2.21566935
77Brushfield spots (HP:0001088)2.21295905
78Pancreatitis (HP:0001733)2.20120929
79Spastic diplegia (HP:0001264)2.14812776
80Abnormality of the Achilles tendon (HP:0005109)2.09749850
81Renal cortical cysts (HP:0000803)2.04080491
82Abnormal tarsal ossification (HP:0008369)2.03674389
83Neonatal onset (HP:0003623)2.03088840
84Enlarged kidneys (HP:0000105)2.01509933
85Skin nodule (HP:0200036)1.99118682
86Abnormality of proline metabolism (HP:0010907)1.99028686
87Hydroxyprolinuria (HP:0003080)1.99028686
88Abnormality of the gallbladder (HP:0005264)1.98325919
89Cholelithiasis (HP:0001081)1.98220964
90Poikilocytosis (HP:0004447)1.97043200
91Hypochromic microcytic anemia (HP:0004840)1.96851456
92Abnormal gallbladder morphology (HP:0012437)1.96298152
93Late onset (HP:0003584)1.96264464
94Sensorimotor neuropathy (HP:0007141)1.96013258
95Reticulocytosis (HP:0001923)1.95017457
96Glomerulonephritis (HP:0000099)1.94300976
97Hemorrhage of the eye (HP:0011885)1.92622097
98Goiter (HP:0000853)1.91575909
99Abnormal cartilage morphology (HP:0002763)1.91506758
100Osteomalacia (HP:0002749)1.91256755
101Back pain (HP:0003418)1.90227686
102Rickets (HP:0002748)1.89009696
103Abnormal enzyme/coenzyme activity (HP:0012379)1.88706925
104Chronic bronchitis (HP:0004469)1.87820405
105Recurrent gram-negative bacterial infections (HP:0005420)1.87121150
106Esophageal varix (HP:0002040)1.86979972
107Thrombophlebitis (HP:0004418)1.86517809
108Nephritis (HP:0000123)1.84480048
109Elevated hepatic transaminases (HP:0002910)1.83809483
110Seborrheic dermatitis (HP:0001051)1.82777363
111Abnormality of vitamin metabolism (HP:0100508)1.82693904
112Pili torti (HP:0003777)1.79379869
113Opisthotonus (HP:0002179)1.78728024
114Megaloblastic anemia (HP:0001889)1.77601480
115Abnormality of transition element cation homeostasis (HP:0011030)1.76983737
116Menorrhagia (HP:0000132)1.76818742
117Hypertriglyceridemia (HP:0002155)1.76716530
118Abnormal hair laboratory examination (HP:0003328)1.75719098
119Elevated alkaline phosphatase (HP:0003155)1.73157306
120Right ventricular cardiomyopathy (HP:0011663)1.72295620
121Spastic paraparesis (HP:0002313)1.67840940
122Paraparesis (HP:0002385)1.67163253
123Abnormality of carpal bone ossification (HP:0006257)1.66834402
124Flat acetabular roof (HP:0003180)1.66830823
125Microvesicular hepatic steatosis (HP:0001414)1.61329799
126Abnormality of alkaline phosphatase activity (HP:0004379)1.60042901
127Pseudobulbar signs (HP:0002200)1.56811803
128Hyperphosphaturia (HP:0003109)1.55936538
129Hypoglycemic seizures (HP:0002173)1.54990898
130Hypophosphatemic rickets (HP:0004912)1.53577850
131Asymmetry of the thorax (HP:0001555)1.53055899
132Azoospermia (HP:0000027)1.51348937
133Abnormality of reticulocytes (HP:0004312)1.50778164
134Mitral stenosis (HP:0001718)1.50398434
135Advanced eruption of teeth (HP:0006288)1.50166705
136Abnormality of the gastric mucosa (HP:0004295)1.49960751
137Lower limb hyperreflexia (HP:0002395)1.49408266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.07054304
2PDK45.81016718
3PDK35.81016718
4PDK23.87939852
5EEF2K3.70020316
6SMG13.07907810
7PBK2.87621291
8FGFR42.83224576
9WNK42.49540210
10ERN12.45475328
11VRK22.42021771
12TSSK62.38556289
13CAMK1D2.19225008
14SIK12.01738636
15TAF11.96465439
16CDC71.90936324
17SRPK11.90592178
18PINK11.90147984
19SCYL21.87810600
20CDK121.85531824
21WNK31.79426139
22TESK11.76024886
23TAOK31.71658700
24WEE11.68546446
25MST1R1.58730872
26STK38L1.56115417
27ICK1.55464555
28CAMK1G1.51636358
29STK161.48376500
30CDK71.47493931
31EIF2AK11.37643708
32TRIB31.37190315
33RPS6KB21.36698149
34EPHA21.33230326
35MST41.29582905
36MAPK111.28962545
37NME11.28208025
38NEK21.26720340
39INSRR1.24365033
40NEK91.21002849
41BRSK11.19759869
42MAP2K31.19696279
43NME21.19615808
44MAP3K31.19355102
45ERBB41.15333931
46LATS21.13977657
47PAK41.10632895
48BUB11.10548215
49NEK11.08622471
50OXSR11.06733077
51FLT31.06648648
52KDR1.06469046
53DYRK1B1.05445947
54TYK21.04869390
55MAPKAPK31.04842259
56PKN21.01965852
57ABL21.01925254
58STK381.00988034
59TIE11.00365665
60STK390.99114179
61IRAK30.95593987
62PIK3CG0.95226588
63PLK30.94098227
64AKT30.90576103
65DYRK30.89770856
66MAP2K60.89600192
67PRKD30.80476281
68MKNK10.79442529
69CHEK20.79331584
70BRSK20.78924609
71ATR0.78902679
72STK30.78647706
73PRKAA10.77676559
74PLK10.77622023
75FRK0.73853070
76MAP2K40.73806292
77AURKB0.73634982
78TBK10.73521369
79PRKAA20.72470504
80FER0.70612739
81PDK10.70259592
82CDK40.70214870
83TTK0.68463254
84LATS10.67934724
85MAP3K80.67751569
86MAP3K110.67589689
87CSNK1E0.66581246
88EIF2AK20.66332937
89MAPK150.66309421
90GRK60.65071369
91PLK40.64448318
92PAK20.64048700
93MAPK40.63991754
94PDPK10.63531667
95CHEK10.62369359
96VRK10.60850045
97AURKA0.60161642
98EIF2AK30.59276166
99CDK80.59188780
100ALK0.58654524
101PASK0.58648071
102ILK0.58571506
103LMTK20.56250549
104CSNK2A20.55530949
105JAK20.54815773
106PTK60.52594143
107PIM20.51323323
108CDK60.51265248
109ACVR1B0.50941075
110MKNK20.50288713
111DMPK0.49800407
112PRKCZ0.49265912
113AKT20.49237462
114IRAK10.48125094
115CDK10.47956477
116PTK2B0.47679726
117MET0.46761654
118ATM0.46638882
119PRKACG0.44697631
120MAP3K50.44371700
121LRRK20.43581118
122CDK20.43420782
123MAPKAPK50.42991354
124MAP3K20.42375914
125ZAP700.40344337
126PIM10.39636429
127FGFR10.39334700
128TAOK20.39097097
129MAP2K20.38418691
130TGFBR20.38244055
131CSF1R0.38129618
132CCNB10.37927176
133RPS6KB10.36663351
134MAP3K70.36507932
135DAPK10.36313058
136MTOR0.35511815
137GSK3A0.35384098
138ERBB20.35287207
139RAF10.32372525
140STK240.31064856
141CAMK2G0.30898321
142SGK30.30691688
143STK40.30662223
144PNCK0.30379707
145IRAK20.30230783
146CDK90.29295080
147MAPK120.29098951
148PRKDC0.28735385
149MAP4K10.28255824
150KIT0.28209846
151BRD40.27501559
152MYLK0.27444180
153ZAK0.23710584
154CSNK2A10.22198440
155PRKCG0.21260606
156TESK20.21030187
157JAK10.19375544
158MAP3K100.19192560
159IKBKE0.18964852
160SGK20.18556412

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84594835
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24115616
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03022780
4Nitrogen metabolism_Homo sapiens_hsa009102.83174090
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82565244
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63078213
7Arginine biosynthesis_Homo sapiens_hsa002202.61180666
8Fatty acid degradation_Homo sapiens_hsa000712.61076039
9Tryptophan metabolism_Homo sapiens_hsa003802.50530264
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44018159
11Propanoate metabolism_Homo sapiens_hsa006402.41161185
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32687776
13Complement and coagulation cascades_Homo sapiens_hsa046102.18840010
14* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17795244
15Butanoate metabolism_Homo sapiens_hsa006502.15598999
16Peroxisome_Homo sapiens_hsa041462.13106934
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01182731
18Vitamin B6 metabolism_Homo sapiens_hsa007501.93392184
19PPAR signaling pathway_Homo sapiens_hsa033201.92006239
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87050619
21Fatty acid metabolism_Homo sapiens_hsa012121.86386533
22Selenocompound metabolism_Homo sapiens_hsa004501.86118109
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85256246
24Chemical carcinogenesis_Homo sapiens_hsa052041.81845383
25Pyruvate metabolism_Homo sapiens_hsa006201.80814415
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.80663182
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78962000
28beta-Alanine metabolism_Homo sapiens_hsa004101.77717282
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.70710453
30Histidine metabolism_Homo sapiens_hsa003401.69479268
31Caffeine metabolism_Homo sapiens_hsa002321.69270026
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.59802597
33Retinol metabolism_Homo sapiens_hsa008301.57964416
34Carbon metabolism_Homo sapiens_hsa012001.50250672
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48872882
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48127957
37Folate biosynthesis_Homo sapiens_hsa007901.44905117
38Biosynthesis of amino acids_Homo sapiens_hsa012301.41210049
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37029137
40Bile secretion_Homo sapiens_hsa049761.36739237
41Phenylalanine metabolism_Homo sapiens_hsa003601.34521400
42Staphylococcus aureus infection_Homo sapiens_hsa051501.29658242
43Vitamin digestion and absorption_Homo sapiens_hsa049771.28319942
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.27026386
45Sulfur metabolism_Homo sapiens_hsa009201.26487939
46Starch and sucrose metabolism_Homo sapiens_hsa005001.25893722
47Fat digestion and absorption_Homo sapiens_hsa049751.21250186
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19271801
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16807440
50Fatty acid elongation_Homo sapiens_hsa000621.13362831
51Tyrosine metabolism_Homo sapiens_hsa003501.11983395
52ABC transporters_Homo sapiens_hsa020101.11454021
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10152122
54Pentose phosphate pathway_Homo sapiens_hsa000301.09855502
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07995810
56Sulfur relay system_Homo sapiens_hsa041221.07581442
57DNA replication_Homo sapiens_hsa030301.04130743
58Arginine and proline metabolism_Homo sapiens_hsa003301.03917711
59Glutathione metabolism_Homo sapiens_hsa004801.03735050
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99454617
61Glycerolipid metabolism_Homo sapiens_hsa005610.97551905
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87911513
63Steroid biosynthesis_Homo sapiens_hsa001000.84748758
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80807007
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.80114266
66Mismatch repair_Homo sapiens_hsa034300.73338762
67One carbon pool by folate_Homo sapiens_hsa006700.72422975
68Lysine degradation_Homo sapiens_hsa003100.70442436
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66744087
70Base excision repair_Homo sapiens_hsa034100.66395798
71Fatty acid biosynthesis_Homo sapiens_hsa000610.65825374
72* Metabolic pathways_Homo sapiens_hsa011000.62621712
73Spliceosome_Homo sapiens_hsa030400.53621132
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51974217
75RNA transport_Homo sapiens_hsa030130.51495731
76* Fructose and mannose metabolism_Homo sapiens_hsa000510.48314150
77Linoleic acid metabolism_Homo sapiens_hsa005910.45841834
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.44893545
79Nucleotide excision repair_Homo sapiens_hsa034200.43710264
80Galactose metabolism_Homo sapiens_hsa000520.43043749
81Ribosome_Homo sapiens_hsa030100.40911956
82Thyroid cancer_Homo sapiens_hsa052160.40551866
83RNA polymerase_Homo sapiens_hsa030200.40098472
84Non-homologous end-joining_Homo sapiens_hsa034500.36860576
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33427401
86Regulation of autophagy_Homo sapiens_hsa041400.29676611
87Cell cycle_Homo sapiens_hsa041100.29035492
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.24765202
89N-Glycan biosynthesis_Homo sapiens_hsa005100.23814206
90Sphingolipid metabolism_Homo sapiens_hsa006000.23384465
91Thyroid hormone synthesis_Homo sapiens_hsa049180.23185864
92mRNA surveillance pathway_Homo sapiens_hsa030150.22870530
93Glucagon signaling pathway_Homo sapiens_hsa049220.21493948
94Pyrimidine metabolism_Homo sapiens_hsa002400.19976920
95Renin-angiotensin system_Homo sapiens_hsa046140.18940002
96Insulin resistance_Homo sapiens_hsa049310.16554819
97Prostate cancer_Homo sapiens_hsa052150.15105427
98Arachidonic acid metabolism_Homo sapiens_hsa005900.13973301
99Proteasome_Homo sapiens_hsa030500.11950172
100Homologous recombination_Homo sapiens_hsa034400.08312561
101AMPK signaling pathway_Homo sapiens_hsa041520.07212508
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.06649006
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06408839
104Mineral absorption_Homo sapiens_hsa049780.05454448
105Prion diseases_Homo sapiens_hsa050200.03654791
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02250667
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02009244
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.2021115
109Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1739178
110Legionellosis_Homo sapiens_hsa05134-0.1680986
111Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1502070
112Lysosome_Homo sapiens_hsa04142-0.1489133
113Insulin signaling pathway_Homo sapiens_hsa04910-0.1439126
114Protein digestion and absorption_Homo sapiens_hsa04974-0.0935642
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0920518
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0178067
117Purine metabolism_Homo sapiens_hsa00230-0.0119475
118Other glycan degradation_Homo sapiens_hsa00511-0.0041279

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