ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	5.50189935
2	L-phenylalanine catabolic process (GO:0006559)	4.71747670
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.71747670
4	exogenous drug catabolic process (GO:0042738)	4.70674678
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.65973079
6	L-phenylalanine metabolic process (GO:0006558)	4.65973079
7	L-serine metabolic process (GO:0006563)	4.59833748
8	serine family amino acid biosynthetic process (GO:0009070)	4.58027728
9	epoxygenase P450 pathway (GO:0019373)	4.51247115
10	omega-hydroxylase P450 pathway (GO:0097267)	4.50353057
11	drug catabolic process (GO:0042737)	4.41224621
12	glycine metabolic process (GO:0006544)	4.26949295
13	serine family amino acid catabolic process (GO:0009071)	4.01261245
14	serine family amino acid metabolic process (GO:0009069)	3.88402285
15	urea metabolic process (GO:0019627)	3.86792707
16	cellular glucuronidation (GO:0052695)	3.80245009
17	uronic acid metabolic process (GO:0006063)	3.79086118
18	glucuronate metabolic process (GO:0019585)	3.79086118
19	ribosome assembly (GO:0042255)	3.75240100
20	bile acid biosynthetic process (GO:0006699)	3.74701019
21	aromatic amino acid family catabolic process (GO:0009074)	3.70561902
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.62489603
23	oxidative demethylation (GO:0070989)	3.58859702
24	aldehyde catabolic process (GO:0046185)	3.56752533
25	regulation of fibrinolysis (GO:0051917)	3.54289221
26	tetrahydrofolate metabolic process (GO:0046653)	3.51779367
27	ethanol oxidation (GO:0006069)	3.50344214
28	S-adenosylmethionine metabolic process (GO:0046500)	3.45029608
29	nitrogen cycle metabolic process (GO:0071941)	3.44101299
30	urea cycle (GO:0000050)	3.43764340
31	ethanol metabolic process (GO:0006067)	3.42320612
32	imidazole-containing compound metabolic process (GO:0052803)	3.42071112
33	branched-chain amino acid catabolic process (GO:0009083)	3.41193200
34	folic acid-containing compound metabolic process (GO:0006760)	3.40655453
35	L-methionine salvage (GO:0071267)	3.36704157
36	L-methionine biosynthetic process (GO:0071265)	3.36704157
37	amino acid salvage (GO:0043102)	3.36704157
38	drug metabolic process (GO:0017144)	3.32876599
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.31344094
40	cysteine metabolic process (GO:0006534)	3.29815610
41	rRNA modification (GO:0000154)	3.28932923
42	cellular ketone body metabolic process (GO:0046950)	3.27722178
43	pteridine-containing compound metabolic process (GO:0042558)	3.26457358
44	pteridine-containing compound biosynthetic process (GO:0042559)	3.21408382
45	regulation of protein activation cascade (GO:2000257)	3.20964491
46	proline metabolic process (GO:0006560)	3.19271295
47	purine nucleobase biosynthetic process (GO:0009113)	3.12677142
48	sulfur amino acid biosynthetic process (GO:0000097)	3.09272814
49	alpha-amino acid catabolic process (GO:1901606)	3.08495124
50	folic acid-containing compound biosynthetic process (GO:0009396)	3.08149360
51	fibrinolysis (GO:0042730)	3.02036891
52	complement activation, alternative pathway (GO:0006957)	3.00101348
53	bile acid metabolic process (GO:0008206)	2.98336275
54	nucleobase biosynthetic process (GO:0046112)	2.97617563
55	rRNA methylation (GO:0031167)	2.96436306
56	regulation of complement activation (GO:0030449)	2.94177946
57	peptidyl-glutamic acid carboxylation (GO:0017187)	2.92517029
58	protein carboxylation (GO:0018214)	2.92517029
59	negative regulation of fibrinolysis (GO:0051918)	2.91348293
60	ketone body metabolic process (GO:1902224)	2.91317473
61	ATP synthesis coupled proton transport (GO:0015986)	2.91097025
62	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.91097025
63	branched-chain amino acid metabolic process (GO:0009081)	2.90761002
64	methionine metabolic process (GO:0006555)	2.90628107
65	transcription from mitochondrial promoter (GO:0006390)	2.89660394
66	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.88650280
67	glutamate metabolic process (GO:0006536)	2.88159006
68	amino-acid betaine metabolic process (GO:0006577)	2.85793030
69	regulation of mitochondrial translation (GO:0070129)	2.83086720
70	blood coagulation, intrinsic pathway (GO:0007597)	2.82671025
71	cellular amino acid catabolic process (GO:0009063)	2.82211013
72	methionine biosynthetic process (GO:0009086)	2.81216545
73	phenylpropanoid metabolic process (GO:0009698)	2.80946032
74	tryptophan catabolic process (GO:0006569)	2.80618997
75	indole-containing compound catabolic process (GO:0042436)	2.80618997
76	indolalkylamine catabolic process (GO:0046218)	2.80618997
77	proteasome assembly (GO:0043248)	2.80485689
78	ribosomal small subunit biogenesis (GO:0042274)	2.80377570
79	establishment of integrated proviral latency (GO:0075713)	2.80144753
80	IMP biosynthetic process (GO:0006188)	2.80090617
81	oxaloacetate metabolic process (GO:0006107)	2.78667278
82	pseudouridine synthesis (GO:0001522)	2.77228059
83	folic acid metabolic process (GO:0046655)	2.75764055
84	primary alcohol catabolic process (GO:0034310)	2.73978653
85	heme transport (GO:0015886)	2.72959853
86	sulfur amino acid catabolic process (GO:0000098)	2.72783185
87	aspartate family amino acid biosynthetic process (GO:0009067)	2.72730652
88	alpha-amino acid biosynthetic process (GO:1901607)	2.72286487
89	biotin metabolic process (GO:0006768)	2.72244238
90	chaperone-mediated protein transport (GO:0072321)	2.71883130
91	homocysteine metabolic process (GO:0050667)	2.71786532
92	nucleobase-containing small molecule interconversion (GO:0015949)	2.71674431
93	tyrosine metabolic process (GO:0006570)	2.68938870
94	cellular aldehyde metabolic process (GO:0006081)	2.68715551
95	sulfur amino acid metabolic process (GO:0000096)	2.68307172
96	DNA strand elongation involved in DNA replication (GO:0006271)	2.66139492
97	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.65772797
98	CENP-A containing nucleosome assembly (GO:0034080)	2.65166121
99	chromatin remodeling at centromere (GO:0031055)	2.64165354
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63996394

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.58481813
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.13495366
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.06459859
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.02179856
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.93905591
6	AR_21909140_ChIP-Seq_LNCAP_Human	3.70459784
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.19969295
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.10863303
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02476436
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.98553735
11	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.81030816
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.80004469
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.72726077
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.68285859
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65550248
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.62994104
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.62604512
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.54382557
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51004063
20	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.45535804
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.30647680
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.25233675
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.19181475
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.14507272
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.12874019
26	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.07390198
27	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.05411458
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.97095540
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.95297765
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91855666
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.91204090
32	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.84818843
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.84364305
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84325798
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83999178
36	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.83681821
37	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.83608677
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.82991548
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82626433
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81836514
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.80743407
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79590095
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78947111
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.77995450
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.76741653
46	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.71084513
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.69356721
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.66062924
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.60580130
50	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.57033322
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.54483693
52	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.54231828
53	CHD1_26751641_Chip-Seq_LNCaP_Human	1.51433864
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.51355122
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49552811
56	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49510506
57	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45128755
58	ZNF263_19887448_ChIP-Seq_K562_Human	1.44908710
59	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34618930
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34426502
61	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.34113499
62	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33772631
63	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.33348169
64	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.33048533
65	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.24433086
66	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.23161379
67	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.20851160
68	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.18530092
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.17164770
70	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.16192792
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12761387
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.11009424
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10324001
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.10281019
75	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.09066846
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07543628
77	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03925175
78	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.03181428
79	ELF5_23300383_ChIP-Seq_T47D_Human	1.01323543
80	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.00708632
81	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99637439
82	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97296813
83	TFEB_21752829_ChIP-Seq_HELA_Human	0.96363083
84	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.95073834
85	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.94848535
86	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.93653013
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92831756
88	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.91808082
89	IGF1R_20145208_ChIP-Seq_DFB_Human	0.90890893
90	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.89889157
91	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.88172786
92	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.85583137
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.84380802
94	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.82540926
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.81939161
96	GATA6_25053715_ChIP-Seq_YYC3_Human	0.81844146
97	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.80721548
98	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.80384585
99	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.78263061
100	IRF1_19129219_ChIP-ChIP_H3396_Human	0.76322232

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.24518356
2	MP0008875_abnormal_xenobiotic_pharmacok	4.47400258
3	MP0003806_abnormal_nucleotide_metabolis	4.19795293
4	MP0005085_abnormal_gallbladder_physiolo	3.93030094
5	MP0005360_urolithiasis	3.75607946
6	MP0005365_abnormal_bile_salt	3.55649941
7	MP0009697_abnormal_copulation	3.43796125
8	MP0003693_abnormal_embryo_hatching	3.29466892
9	MP0003195_calcinosis	3.00095989
10	MP0010094_abnormal_chromosome_stability	2.95087196
11	MP0001666_abnormal_nutrient_absorption	2.70026942
12	MP0004957_abnormal_blastocyst_morpholog	2.68055968
13	MP0003941_abnormal_skin_development	2.67601354
14	MP0008058_abnormal_DNA_repair	2.52395914
15	MP0003718_maternal_effect	2.39978189
16	MP0001764_abnormal_homeostasis	2.35445473
17	MP0003111_abnormal_nucleus_morphology	2.31755047
18	MP0005332_abnormal_amino_acid	2.25831280
19	MP0003186_abnormal_redox_activity	2.16180238
20	MP0003077_abnormal_cell_cycle	2.16169097
21	MP0010234_abnormal_vibrissa_follicle	1.99267382
22	MP0003252_abnormal_bile_duct	1.96063959
23	MP0006036_abnormal_mitochondrial_physio	1.90094866
24	MP0003868_abnormal_feces_composition	1.88066045
25	MP0002138_abnormal_hepatobiliary_system	1.85044312
26	MP0008007_abnormal_cellular_replicative	1.69826045
27	MP0003011_delayed_dark_adaptation	1.68966300
28	MP0008057_abnormal_DNA_replication	1.61600932
29	MP0005408_hypopigmentation	1.61014206
30	MP0008932_abnormal_embryonic_tissue	1.58305416
31	MP0002796_impaired_skin_barrier	1.54307123
32	MP0003315_abnormal_perineum_morphology	1.53971002
33	MP0010329_abnormal_lipoprotein_level	1.49501696
34	MP0006035_abnormal_mitochondrial_morpho	1.45008560
35	MP0002132_abnormal_respiratory_system	1.38994838
36	MP0004019_abnormal_vitamin_homeostasis	1.38586558
37	MP0001730_embryonic_growth_arrest	1.37522848
38	MP0000609_abnormal_liver_physiology	1.34261468
39	MP0002876_abnormal_thyroid_physiology	1.33271007
40	MP0003656_abnormal_erythrocyte_physiolo	1.27423044
41	MP0005395_other_phenotype	1.23923834
42	MP0005636_abnormal_mineral_homeostasis	1.22392817
43	MP0001661_extended_life_span	1.21165615
44	MP0003786_premature_aging	1.19613476
45	MP0005319_abnormal_enzyme/_coenzyme	1.14709654
46	MP0001188_hyperpigmentation	1.12403375
47	MP0005501_abnormal_skin_physiology	1.11687108
48	MP0005451_abnormal_body_composition	1.10675696
49	MP0005220_abnormal_exocrine_pancreas	1.07882133
50	MP0005647_abnormal_sex_gland	1.05286949
51	MP0000350_abnormal_cell_proliferation	1.04228579
52	MP0004858_abnormal_nervous_system	0.97214400
53	MP0002166_altered_tumor_susceptibility	0.95714441
54	MP0002090_abnormal_vision	0.95368050
55	MP0009643_abnormal_urine_homeostasis	0.91761137
56	MP0002118_abnormal_lipid_homeostasis	0.91547185
57	MP0003890_abnormal_embryonic-extraembry	0.89501208
58	MP0008789_abnormal_olfactory_epithelium	0.88440602
59	MP0000537_abnormal_urethra_morphology	0.87557175
60	MP0003123_paternal_imprinting	0.87235451
61	MP0005187_abnormal_penis_morphology	0.86752688
62	MP0000598_abnormal_liver_morphology	0.85849466
63	MP0000358_abnormal_cell_content/	0.83358121
64	MP0002160_abnormal_reproductive_system	0.82170603
65	MP0005410_abnormal_fertilization	0.81560714
66	MP0001697_abnormal_embryo_size	0.80171430
67	MP0009672_abnormal_birth_weight	0.79991308
68	MP0001881_abnormal_mammary_gland	0.78953737
69	MP0002080_prenatal_lethality	0.77903548
70	MP0001672_abnormal_embryogenesis/_devel	0.77828647
71	MP0005380_embryogenesis_phenotype	0.77828647
72	MP0005376_homeostasis/metabolism_phenot	0.76948609
73	MP0001929_abnormal_gametogenesis	0.76254890
74	MP0000372_irregular_coat_pigmentation	0.75109702
75	MP0001919_abnormal_reproductive_system	0.73329669
76	MP0000313_abnormal_cell_death	0.72203233
77	MP0005584_abnormal_enzyme/coenzyme_acti	0.72115419
78	MP0000678_abnormal_parathyroid_gland	0.66224426
79	MP0005499_abnormal_olfactory_system	0.64862521
80	MP0005394_taste/olfaction_phenotype	0.64862521
81	MP0006072_abnormal_retinal_apoptosis	0.64313710
82	MP0003984_embryonic_growth_retardation	0.62694273
83	MP0002006_tumorigenesis	0.62197539
84	MP0001853_heart_inflammation	0.62106461
85	MP0002088_abnormal_embryonic_growth/wei	0.61847162
86	MP0002163_abnormal_gland_morphology	0.61684608
87	MP0001145_abnormal_male_reproductive	0.59088379
88	MP0008872_abnormal_physiological_respon	0.58670295
89	MP0000653_abnormal_sex_gland	0.57738483
90	MP0005266_abnormal_metabolism	0.57463709
91	MP0001727_abnormal_embryo_implantation	0.56920987
92	MP0002019_abnormal_tumor_incidence	0.56490988
93	MP0009642_abnormal_blood_homeostasis	0.56100967
94	MP0004043_abnormal_pH_regulation	0.56068367
95	MP0004782_abnormal_surfactant_physiolog	0.55101909
96	MP0004264_abnormal_extraembryonic_tissu	0.54832681
97	MP0002938_white_spotting	0.54604132
98	MP0005084_abnormal_gallbladder_morpholo	0.52995601
99	MP0005389_reproductive_system_phenotype	0.52798736
100	MP0002084_abnormal_developmental_patter	0.52407628

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.72942373
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.64116549
3	Prolonged partial thromboplastin time (HP:0003645)	5.25417610
4	Hypobetalipoproteinemia (HP:0003563)	4.54118245
5	Hyperglycinemia (HP:0002154)	4.18171155
6	Abnormality of methionine metabolism (HP:0010901)	4.13239733
7	Deep venous thrombosis (HP:0002625)	4.12594166
8	Abnormality of glycine metabolism (HP:0010895)	4.10844909
9	Abnormality of serine family amino acid metabolism (HP:0010894)	4.10844909
10	Intrahepatic cholestasis (HP:0001406)	3.82965950
11	Hyperglycinuria (HP:0003108)	3.79026877
12	Acute encephalopathy (HP:0006846)	3.56023164
13	Abnormality of serum amino acid levels (HP:0003112)	3.55836993
14	Reduced antithrombin III activity (HP:0001976)	3.36438855
15	Complement deficiency (HP:0004431)	3.27809961
16	Cerebral edema (HP:0002181)	3.26740668
17	Hyperammonemia (HP:0001987)	3.20800900
18	Conjugated hyperbilirubinemia (HP:0002908)	3.16110765
19	Generalized aminoaciduria (HP:0002909)	3.12634827
20	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.08760571
21	Delayed CNS myelination (HP:0002188)	3.03225030
22	Acute necrotizing encephalopathy (HP:0006965)	2.96860349
23	Abnormality of glycolysis (HP:0004366)	2.92934431
24	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.92578198
25	Increased serum pyruvate (HP:0003542)	2.92486942
26	Abnormality of pyrimidine metabolism (HP:0004353)	2.85562466
27	Lethargy (HP:0001254)	2.81194558
28	Abnormality of the intrinsic pathway (HP:0010989)	2.79239842
29	Lipid accumulation in hepatocytes (HP:0006561)	2.78686019
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74904323
31	Megaloblastic anemia (HP:0001889)	2.61993695
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.61465353
33	Abnormality of alanine metabolism (HP:0010916)	2.61465353
34	Hyperalaninemia (HP:0003348)	2.61465353
35	Metabolic acidosis (HP:0001942)	2.60214186
36	Gout (HP:0001997)	2.55618166
37	Hypolipoproteinemia (HP:0010981)	2.54132034
38	Hypoglycemic coma (HP:0001325)	2.50014383
39	Abnormality of complement system (HP:0005339)	2.49723583
40	Fat malabsorption (HP:0002630)	2.47567307
41	Renal Fanconi syndrome (HP:0001994)	2.46080083
42	Mitochondrial inheritance (HP:0001427)	2.45247267
43	Ketosis (HP:0001946)	2.44556751
44	Increased CSF lactate (HP:0002490)	2.44351431
45	Hepatic necrosis (HP:0002605)	2.42729706
46	Increased hepatocellular lipid droplets (HP:0006565)	2.42115320
47	Increased serum lactate (HP:0002151)	2.41035313
48	Multiple enchondromatosis (HP:0005701)	2.38377485
49	Methylmalonic acidemia (HP:0002912)	2.34240789
50	Hyperphosphaturia (HP:0003109)	2.31122271
51	Progressive macrocephaly (HP:0004481)	2.30990030
52	Steatorrhea (HP:0002570)	2.28634929
53	Hepatocellular necrosis (HP:0001404)	2.28218425
54	Abnormality of urine glucose concentration (HP:0011016)	2.27858360
55	Glycosuria (HP:0003076)	2.27858360
56	Macrocytic anemia (HP:0001972)	2.26739810
57	Abnormality of vitamin metabolism (HP:0100508)	2.25739237
58	Joint hemorrhage (HP:0005261)	2.22988222
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.19888297
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.19888297
61	Lactic acidosis (HP:0003128)	2.18774921
62	3-Methylglutaconic aciduria (HP:0003535)	2.10722549
63	Hyperbilirubinemia (HP:0002904)	2.03495973
64	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.00734923
65	Dicarboxylic aciduria (HP:0003215)	2.00734923
66	Spontaneous abortion (HP:0005268)	1.98921667
67	Abnormality of fatty-acid metabolism (HP:0004359)	1.98897297
68	Ketoacidosis (HP:0001993)	1.98593527
69	Abnormality of nucleobase metabolism (HP:0010932)	1.97430150
70	Proximal tubulopathy (HP:0000114)	1.93353212
71	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.92251838
72	Microvesicular hepatic steatosis (HP:0001414)	1.91928476
73	Sparse eyelashes (HP:0000653)	1.90037013
74	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.89153148
75	Rickets (HP:0002748)	1.87095537
76	Abnormal urine phosphate concentration (HP:0012599)	1.84738336
77	Azoospermia (HP:0000027)	1.83697134
78	Neoplasm of the adrenal gland (HP:0100631)	1.80679556
79	Vomiting (HP:0002013)	1.80413201
80	Methylmalonic aciduria (HP:0012120)	1.78967170
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.78698061
82	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.76952550
83	Abnormality of the preputium (HP:0100587)	1.76865286
84	Abnormal number of erythroid precursors (HP:0012131)	1.75898207
85	Abnormality of renal resorption (HP:0011038)	1.75763188
86	Chromsome breakage (HP:0040012)	1.75131501
87	Pancytopenia (HP:0001876)	1.73179442
88	Testicular atrophy (HP:0000029)	1.70680015
89	Hypoplasia of the uterus (HP:0000013)	1.70271338
90	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.69122518
91	Abnormal spermatogenesis (HP:0008669)	1.68999236
92	Respiratory difficulties (HP:0002880)	1.68083083
93	Respiratory failure (HP:0002878)	1.67987314
94	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.67955945
95	Abnormal protein N-linked glycosylation (HP:0012347)	1.67955945
96	Abnormal protein glycosylation (HP:0012346)	1.67955945
97	Abnormal glycosylation (HP:0012345)	1.67955945
98	Abnormal tarsal ossification (HP:0008369)	1.67470055
99	Type I transferrin isoform profile (HP:0003642)	1.67373156
100	Hepatocellular carcinoma (HP:0001402)	1.66898517

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.78030695
2	BUB1	3.59676217
3	EIF2AK1	3.55658947
4	NEK1	3.38667786
5	EIF2AK3	3.00398169
6	NME2	2.99410390
7	TSSK6	2.97230557
8	PBK	2.92080785
9	MST4	2.78793806
10	TAF1	2.77932757
11	AKT3	2.66859676
12	TTK	2.60217186
13	CDC7	2.44289972
14	SRPK1	2.33381804
15	PLK4	2.26764448
16	WEE1	2.11557524
17	BRSK2	2.01374840
18	STK16	1.98702886
19	SMG1	1.90722244
20	EPHA2	1.87854046
21	PLK3	1.73303525
22	ZAK	1.62822722
23	MKNK2	1.61731904
24	NUAK1	1.52019621
25	PRKD3	1.51428521
26	STK24	1.43425101
27	MKNK1	1.39249288
28	EEF2K	1.38996739
29	VRK1	1.30963341
30	NME1	1.29016877
31	STK39	1.25669944
32	PLK1	1.19939159
33	BRAF	1.17597452
34	CDK7	1.13606966
35	PDK2	1.06114626
36	BRSK1	1.03771767
37	EIF2AK2	1.02994643
38	AURKB	0.98147036
39	BCKDK	0.96918030
40	DYRK3	0.94253626
41	RPS6KB2	0.88442581
42	BMPR1B	0.87757762
43	PASK	0.84291012
44	RPS6KA4	0.83667517
45	NEK2	0.82424535
46	GRK1	0.82120167
47	STK3	0.81593817
48	CHEK2	0.81541494
49	CAMK1D	0.81392308
50	MAP3K9	0.78304505
51	ATR	0.76951886
52	MAP3K8	0.76905499
53	TRIM28	0.74606238
54	DAPK1	0.72109482
55	STK38L	0.71797886
56	CSNK1G1	0.70734540
57	AURKA	0.68798416
58	SCYL2	0.68555655
59	CSNK1G3	0.67576906
60	LATS2	0.66317097
61	CSNK2A2	0.66312864
62	WNK4	0.65972526
63	STK4	0.65206170
64	ARAF	0.64551620
65	CSNK1A1L	0.63390828
66	IRAK3	0.62417268
67	WNK3	0.61391126
68	CHEK1	0.56385497
69	PAK4	0.56282845
70	CSNK2A1	0.55908148
71	MST1R	0.55150778
72	ILK	0.52978591
73	CSNK1E	0.52941968
74	ATM	0.52508840
75	ALK	0.51279959
76	PIM2	0.50836377
77	PRKCI	0.50422695
78	TGFBR1	0.49523128
79	CCNB1	0.46396174
80	LATS1	0.46010214
81	NEK9	0.44696135
82	ERBB3	0.43755134
83	MAPKAPK3	0.40163138
84	STK10	0.39013240
85	DYRK2	0.36314025
86	MAP4K2	0.34960936
87	ERBB4	0.33810753
88	MELK	0.32966942
89	CDK8	0.32434967
90	BCR	0.31739331
91	MAP3K12	0.31328801
92	RPS6KA5	0.29808264
93	MAPKAPK5	0.29791308
94	CDK1	0.29152924
95	MYLK	0.27642473
96	CSNK1A1	0.27156643
97	CDK9	0.26689722
98	AKT2	0.26543876
99	NLK	0.26205041
100	CAMK1G	0.25920014

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.02483663
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.83325677
3	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.56651823
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.56578818
5	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.49585237
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.47492027
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.23799150
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.20756958
9	Retinol metabolism_Homo sapiens_hsa00830	2.15445160
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.09204846
11	Phenylalanine metabolism_Homo sapiens_hsa00360	2.03219874
12	Chemical carcinogenesis_Homo sapiens_hsa05204	2.01089855
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.00156029
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98549435
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.97198901
16	Fatty acid degradation_Homo sapiens_hsa00071	1.96904948
17	One carbon pool by folate_Homo sapiens_hsa00670	1.95029715
18	Proteasome_Homo sapiens_hsa03050	1.94660168
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.94106313
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.88927661
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.88302342
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.83864159
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.81247182
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.76983041
25	Ribosome_Homo sapiens_hsa03010	1.70903238
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69386073
27	Propanoate metabolism_Homo sapiens_hsa00640	1.66625524
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64584180
29	DNA replication_Homo sapiens_hsa03030	1.64484131
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64072798
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.61969454
32	Butanoate metabolism_Homo sapiens_hsa00650	1.60232171
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.59782885
34	Complement and coagulation cascades_Homo sapiens_hsa04610	1.45561169
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.45277255
36	Mismatch repair_Homo sapiens_hsa03430	1.42100346
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40804193
38	Histidine metabolism_Homo sapiens_hsa00340	1.40356048
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.39846257
40	Carbon metabolism_Homo sapiens_hsa01200	1.39111832
41	RNA polymerase_Homo sapiens_hsa03020	1.36733939
42	Peroxisome_Homo sapiens_hsa04146	1.32467721
43	Arginine and proline metabolism_Homo sapiens_hsa00330	1.32374947
44	Sulfur metabolism_Homo sapiens_hsa00920	1.31421823
45	Protein export_Homo sapiens_hsa03060	1.25145226
46	beta-Alanine metabolism_Homo sapiens_hsa00410	1.23893532
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.21729161
48	Base excision repair_Homo sapiens_hsa03410	1.18507260
49	Sulfur relay system_Homo sapiens_hsa04122	1.15298469
50	Oxidative phosphorylation_Homo sapiens_hsa00190	1.11879987
51	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10908233
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08560601
53	Fatty acid metabolism_Homo sapiens_hsa01212	1.08427064
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.08094371
55	Glutathione metabolism_Homo sapiens_hsa00480	1.07482419
56	Fatty acid elongation_Homo sapiens_hsa00062	1.02429643
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94831571
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.93647340
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93212512
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92821558
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.92648187
62	Parkinsons disease_Homo sapiens_hsa05012	0.92332879
63	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.92078113
64	Homologous recombination_Homo sapiens_hsa03440	0.90743138
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.90681008
66	RNA transport_Homo sapiens_hsa03013	0.89907620
67	Metabolic pathways_Homo sapiens_hsa01100	0.84210087
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84139080
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83395499
70	Spliceosome_Homo sapiens_hsa03040	0.83295534
71	Folate biosynthesis_Homo sapiens_hsa00790	0.82234274
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78229457
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.76930382
74	Huntingtons disease_Homo sapiens_hsa05016	0.74419472
75	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68768696
76	Bile secretion_Homo sapiens_hsa04976	0.65837811
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.65175181
78	Basal transcription factors_Homo sapiens_hsa03022	0.61759086
79	Pentose phosphate pathway_Homo sapiens_hsa00030	0.61568408
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.58870002
81	RNA degradation_Homo sapiens_hsa03018	0.58514009
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57771396
83	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56309097
84	Purine metabolism_Homo sapiens_hsa00230	0.54632469
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50730725
86	Cell cycle_Homo sapiens_hsa04110	0.49286913
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48535661
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47490016
89	Mineral absorption_Homo sapiens_hsa04978	0.44347914
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43911238
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43851732
92	Alzheimers disease_Homo sapiens_hsa05010	0.41851913
93	Lysine degradation_Homo sapiens_hsa00310	0.35915319
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.31526718
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.25070938
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23407751
97	p53 signaling pathway_Homo sapiens_hsa04115	0.19905714
98	Renin-angiotensin system_Homo sapiens_hsa04614	0.15514289
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.09085416
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.07707948

SORD2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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