SORT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.17574761
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16332918
3locomotory exploration behavior (GO:0035641)5.01270371
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81155637
5vocalization behavior (GO:0071625)4.54424743
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53406920
7synaptic vesicle exocytosis (GO:0016079)4.33144180
8glutamate secretion (GO:0014047)4.29831724
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.25684705
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25444946
11regulation of synaptic vesicle exocytosis (GO:2000300)4.11596066
12regulation of glutamate receptor signaling pathway (GO:1900449)4.09766278
13regulation of neuronal synaptic plasticity (GO:0048168)4.05169662
14axon ensheathment in central nervous system (GO:0032291)4.01868447
15central nervous system myelination (GO:0022010)4.01868447
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.97786535
17cellular potassium ion homeostasis (GO:0030007)3.95153943
18regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91112544
19neuronal action potential propagation (GO:0019227)3.88994793
20dendritic spine morphogenesis (GO:0060997)3.88793704
21regulation of synapse structural plasticity (GO:0051823)3.87904410
22sodium ion export (GO:0071436)3.80385573
23layer formation in cerebral cortex (GO:0021819)3.78495830
24exploration behavior (GO:0035640)3.70161433
25protein localization to synapse (GO:0035418)3.68189476
26regulation of synaptic vesicle transport (GO:1902803)3.65515999
27activation of protein kinase A activity (GO:0034199)3.54465958
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48826079
29cerebellar granule cell differentiation (GO:0021707)3.46078692
30glutamate receptor signaling pathway (GO:0007215)3.45554384
31synaptic transmission, glutamatergic (GO:0035249)3.45551024
32long-term memory (GO:0007616)3.43470880
33proline transport (GO:0015824)3.42015292
34neurotransmitter secretion (GO:0007269)3.40766690
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37804241
36regulation of dendritic spine morphogenesis (GO:0061001)3.33033460
37glycine transport (GO:0015816)3.30936371
38neuron cell-cell adhesion (GO:0007158)3.29936489
39cell communication involved in cardiac conduction (GO:0086065)3.28660000
40L-amino acid import (GO:0043092)3.28110396
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27010290
42neuron-neuron synaptic transmission (GO:0007270)3.24694643
43regulation of synaptic plasticity (GO:0048167)3.23051749
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22006378
45neurotransmitter-gated ion channel clustering (GO:0072578)3.21977525
46neuromuscular process controlling balance (GO:0050885)3.21325946
47dendritic spine organization (GO:0097061)3.16875771
48regulation of ARF protein signal transduction (GO:0032012)3.14626775
49regulation of postsynaptic membrane potential (GO:0060078)3.09716611
50positive regulation of membrane potential (GO:0045838)3.08893167
51neuron recognition (GO:0008038)3.08085476
52G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03377273
53negative regulation of dendrite morphogenesis (GO:0050774)3.01120125
54potassium ion import (GO:0010107)2.98684772
55cell communication by electrical coupling (GO:0010644)2.98484302
56axonal fasciculation (GO:0007413)2.98321212
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96441325
58melanin biosynthetic process (GO:0042438)2.96360358
59cellular sodium ion homeostasis (GO:0006883)2.95237894
60long-term synaptic potentiation (GO:0060291)2.93903424
61positive regulation of synapse maturation (GO:0090129)2.88103188
62response to auditory stimulus (GO:0010996)2.88090439
63gamma-aminobutyric acid transport (GO:0015812)2.86878081
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.85846274
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84905621
66vesicle transport along microtubule (GO:0047496)2.83320616
67dendrite morphogenesis (GO:0048813)2.82880159
68neuronal ion channel clustering (GO:0045161)2.81967997
69membrane hyperpolarization (GO:0060081)2.80965991
70establishment of nucleus localization (GO:0040023)2.80028684
71auditory behavior (GO:0031223)2.79611307
72chemosensory behavior (GO:0007635)2.79328030
73regulation of dendritic spine development (GO:0060998)2.79318013
74neurotransmitter transport (GO:0006836)2.78914344
75transmission of nerve impulse (GO:0019226)2.78566469
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.78370408
77gamma-aminobutyric acid signaling pathway (GO:0007214)2.77397273
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76265051
79potassium ion homeostasis (GO:0055075)2.76127712
80regulation of clathrin-mediated endocytosis (GO:2000369)2.75397137
81regulation of neurotransmitter secretion (GO:0046928)2.75219614
82mating behavior (GO:0007617)2.74685682
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74396733
84postsynaptic membrane organization (GO:0001941)2.73321111
85synaptic vesicle endocytosis (GO:0048488)2.72600710
86myelin maintenance (GO:0043217)2.72274008
87cerebellar Purkinje cell differentiation (GO:0021702)2.72240522
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71908347
89innervation (GO:0060384)2.71270416
90membrane depolarization (GO:0051899)2.70858727
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.70418253
92regulation of vesicle fusion (GO:0031338)2.70254527
93suckling behavior (GO:0001967)2.69647475
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68752786
95long term synaptic depression (GO:0060292)2.66718737
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.64958533
97positive regulation of neurotransmitter secretion (GO:0001956)2.64101470
98membrane depolarization during action potential (GO:0086010)2.63063981
99regulation of voltage-gated calcium channel activity (GO:1901385)2.61899562
100regulation of neurotransmitter levels (GO:0001505)2.59740264
101cellular response to catecholamine stimulus (GO:0071870)2.59212731
102cellular response to monoamine stimulus (GO:0071868)2.59212731
103positive regulation of dendritic spine development (GO:0060999)2.58720365
104positive regulation of synaptic transmission (GO:0050806)2.58550230
105prepulse inhibition (GO:0060134)2.58376578
106regulation of synaptic transmission (GO:0050804)2.58034749
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57361063
108regulation of neurotransmitter transport (GO:0051588)2.56486743
109positive regulation of neurotransmitter transport (GO:0051590)2.55710238
110adult walking behavior (GO:0007628)2.54590311
111amino acid import (GO:0043090)2.53613627
112learning (GO:0007612)2.53470675
113neuromuscular process (GO:0050905)2.53468806
114melanin metabolic process (GO:0006582)2.53363479
115astrocyte development (GO:0014002)2.50764759
116myelination (GO:0042552)2.50235141
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47818168
118embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46209598
119regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.45190576
120ensheathment of neurons (GO:0007272)2.44804109
121axon ensheathment (GO:0008366)2.44804109
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.44310275
123neurotransmitter uptake (GO:0001504)2.41143199
124myelination in peripheral nervous system (GO:0022011)2.40855980
125peripheral nervous system axon ensheathment (GO:0032292)2.40855980
126clathrin coat assembly (GO:0048268)2.40107914
127detection of calcium ion (GO:0005513)2.40022654
128cerebellar Purkinje cell layer development (GO:0021680)2.39587362
129regulation of cell communication by electrical coupling (GO:0010649)2.38056469
130response to catecholamine (GO:0071869)2.36381522
131response to monoamine (GO:0071867)2.36381522
132long-chain fatty acid biosynthetic process (GO:0042759)2.35137866
133presynaptic membrane organization (GO:0097090)2.34372575
134regulation of synapse maturation (GO:0090128)2.31550259
135regulation of early endosome to late endosome transport (GO:2000641)2.30744406
136presynaptic membrane assembly (GO:0097105)2.27676737
137positive regulation of dendrite development (GO:1900006)2.26701195
138positive regulation of glucose transport (GO:0010828)2.24760371
139acidic amino acid transport (GO:0015800)2.24636483
140membrane assembly (GO:0071709)2.21553657
141positive regulation of glucose import (GO:0046326)2.21205041
142positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.21061132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85157489
2GBX2_23144817_ChIP-Seq_PC3_Human2.88099068
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80711672
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78953427
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64223042
6DROSHA_22980978_ChIP-Seq_HELA_Human2.59819088
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.52150674
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51469321
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51469321
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43540813
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37737162
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35677442
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35136238
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26793744
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23203038
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.18831928
17REST_21632747_ChIP-Seq_MESCs_Mouse2.18410037
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.07134430
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05923407
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.03355355
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.02158648
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98755432
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96981739
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.93548194
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78860206
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.77674955
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76103913
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75277775
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68542249
30AR_21572438_ChIP-Seq_LNCaP_Human1.63914642
31CLOCK_20551151_ChIP-Seq_293T_Human1.63021205
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55354417
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53379905
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47050949
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46253376
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.45715969
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42125134
38WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41509347
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.41040860
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40066621
41SMAD4_21799915_ChIP-Seq_A2780_Human1.39919710
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39072539
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36480297
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36281945
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34818157
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34136099
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29893191
48* KDM2B_26808549_Chip-Seq_K562_Human1.29822218
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27089419
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.26597218
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26505453
52AHR_22903824_ChIP-Seq_MCF-7_Human1.26197632
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.22202528
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21971890
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.21391371
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.20357665
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.20357665
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19668691
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19589607
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17594027
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16657095
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16360894
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.15610459
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14717417
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14585573
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14471036
67AR_19668381_ChIP-Seq_PC3_Human1.14230428
68ZNF274_21170338_ChIP-Seq_K562_Hela1.14058313
69STAT3_23295773_ChIP-Seq_U87_Human1.12374228
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12031858
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.11830102
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10776212
73AR_25329375_ChIP-Seq_VCAP_Human1.09991898
74TP53_16413492_ChIP-PET_HCT116_Human1.09718969
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09339600
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08816119
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08544812
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08279008
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.07560225
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06353851
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05388190
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04871976
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04297110
84RXR_22108803_ChIP-Seq_LS180_Human1.03797318
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.03128228
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.02984682
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02738460
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02535387
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.02256564
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01879244
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01271282
92TAF15_26573619_Chip-Seq_HEK293_Human1.00492077
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.99425168
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99354464
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99232467
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99103837
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99092294
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99037837
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98881691
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.98693051
101TCF4_23295773_ChIP-Seq_U87_Human0.98306360
102P300_19829295_ChIP-Seq_ESCs_Human0.97504327
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97099890
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96530733
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96282470
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.95713947
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.95210008
108WT1_19549856_ChIP-ChIP_CCG9911_Human0.94858119
109TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93878119
110P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93376510
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93089307
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.92163512
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91132674
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91132674
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88885728
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88882787
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.87913248
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.87466082
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86525018
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86392962
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85930663
122* MITF_21258399_ChIP-Seq_MELANOMA_Human0.83501713
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.83131421
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82876826
125* RUNX2_22187159_ChIP-Seq_PCA_Human0.82850199
126* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82524397
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82438435
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81533838
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.81117696
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81046260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58987593
2MP0003880_abnormal_central_pattern4.13992367
3MP0003635_abnormal_synaptic_transmissio3.86351591
4MP0004270_analgesia3.76165871
5MP0002063_abnormal_learning/memory/cond3.08544241
6MP0009745_abnormal_behavioral_response3.01762101
7MP0002064_seizures2.88512849
8MP0009780_abnormal_chondrocyte_physiolo2.77529798
9MP0002822_catalepsy2.74786563
10MP0009046_muscle_twitch2.49538038
11MP0001486_abnormal_startle_reflex2.46764088
12MP0002572_abnormal_emotion/affect_behav2.43202456
13MP0002272_abnormal_nervous_system2.38351876
14MP0001501_abnormal_sleep_pattern2.25548879
15MP0001968_abnormal_touch/_nociception2.21619973
16MP0003329_amyloid_beta_deposits2.19912560
17MP0002734_abnormal_mechanical_nocicepti2.17992027
18MP0002909_abnormal_adrenal_gland2.09482779
19MP0005423_abnormal_somatic_nervous2.03271079
20MP0003705_abnormal_hypodermis_morpholog1.93806283
21MP0004858_abnormal_nervous_system1.91094685
22MP0008569_lethality_at_weaning1.83927064
23MP0004885_abnormal_endolymph1.80115469
24MP0003690_abnormal_glial_cell1.78905661
25MP0002877_abnormal_melanocyte_morpholog1.78208775
26MP0001440_abnormal_grooming_behavior1.76327687
27MP0001970_abnormal_pain_threshold1.62744809
28MP0003136_yellow_coat_color1.62706143
29MP0003633_abnormal_nervous_system1.61890158
30MP0010234_abnormal_vibrissa_follicle1.61496420
31MP0002733_abnormal_thermal_nociception1.60322696
32MP0002736_abnormal_nociception_after1.58299449
33MP0005257_abnormal_intraocular_pressure1.57627324
34MP0002067_abnormal_sensory_capabilities1.57028797
35MP0004811_abnormal_neuron_physiology1.55505989
36MP0000778_abnormal_nervous_system1.50135257
37MP0002735_abnormal_chemical_nociception1.49206573
38MP0000920_abnormal_myelination1.48700608
39MP0003122_maternal_imprinting1.48568741
40MP0003075_altered_response_to1.48207975
41MP0004924_abnormal_behavior1.46963034
42MP0005386_behavior/neurological_phenoty1.46963034
43MP0002557_abnormal_social/conspecific_i1.46591908
44MP0000013_abnormal_adipose_tissue1.43054660
45MP0004130_abnormal_muscle_cell1.40336332
46MP0001958_emphysema1.39816404
47MP0003123_paternal_imprinting1.33131840
48MP0003879_abnormal_hair_cell1.33007215
49* MP0000955_abnormal_spinal_cord1.32884636
50MP0005646_abnormal_pituitary_gland1.32010930
51MP0008961_abnormal_basal_metabolism1.29376453
52MP0002066_abnormal_motor_capabilities/c1.29047180
53MP0003631_nervous_system_phenotype1.28973079
54MP0002184_abnormal_innervation1.27433420
55MP0000749_muscle_degeneration1.27404860
56MP0001177_atelectasis1.26522866
57MP0005645_abnormal_hypothalamus_physiol1.26415946
58* MP0002882_abnormal_neuron_morphology1.24756571
59MP0005167_abnormal_blood-brain_barrier1.24467118
60MP0003283_abnormal_digestive_organ1.23988944
61MP0005408_hypopigmentation1.21004519
62MP0002837_dystrophic_cardiac_calcinosis1.18757715
63MP0008438_abnormal_cutaneous_collagen1.16256185
64MP0000751_myopathy1.13501323
65MP0004084_abnormal_cardiac_muscle1.13163921
66MP0003634_abnormal_glial_cell1.12798112
67MP0004043_abnormal_pH_regulation1.12408666
68MP0000569_abnormal_digit_pigmentation1.10418999
69MP0000604_amyloidosis1.08772940
70MP0001502_abnormal_circadian_rhythm1.07629155
71MP0005535_abnormal_body_temperature1.05861065
72MP0006138_congestive_heart_failure1.05752796
73MP0004272_abnormal_basement_membrane1.05224890
74MP0001984_abnormal_olfaction1.04750792
75MP0003566_abnormal_cell_adhesion1.03258946
76MP0004185_abnormal_adipocyte_glucose1.03081865
77MP0002090_abnormal_vision1.02614440
78MP0002229_neurodegeneration1.00243908
79MP0004145_abnormal_muscle_electrophysio0.99659737
80MP0004087_abnormal_muscle_fiber0.99042174
81MP0005171_absent_coat_pigmentation0.98766015
82MP0003172_abnormal_lysosome_physiology0.96594619
83MP0010386_abnormal_urinary_bladder0.95112999
84MP0002152_abnormal_brain_morphology0.94457827
85MP0000003_abnormal_adipose_tissue0.94362955
86MP0002069_abnormal_eating/drinking_beha0.93153581
87MP0002971_abnormal_brown_adipose0.91793681
88MP0003045_fibrosis0.90198410
89MP0003632_abnormal_nervous_system0.89569035
90MP0005248_abnormal_Harderian_gland0.88986238
91MP0002269_muscular_atrophy0.88906067
92MP0003787_abnormal_imprinting0.87742210
93MP0005375_adipose_tissue_phenotype0.86805425
94MP0002089_abnormal_postnatal_growth/wei0.86175881
95MP0001485_abnormal_pinna_reflex0.85253524
96MP0000534_abnormal_ureter_morphology0.84214666
97MP0008874_decreased_physiological_sensi0.83475332
98MP0002896_abnormal_bone_mineralization0.82135633
99MP0004742_abnormal_vestibular_system0.81585304
100MP0001664_abnormal_digestion0.81218487
101MP0000372_irregular_coat_pigmentation0.81007754
102MP0005377_hearing/vestibular/ear_phenot0.80658208
103MP0003878_abnormal_ear_physiology0.80658208
104MP0005666_abnormal_adipose_tissue0.80054752
105MP0004085_abnormal_heartbeat0.79712945
106MP0004484_altered_response_of0.79528756
107MP0001529_abnormal_vocalization0.79180085
108MP0005670_abnormal_white_adipose0.79133491
109MP0005551_abnormal_eye_electrophysiolog0.77914595
110MP0000015_abnormal_ear_pigmentation0.77347783
111MP0003091_abnormal_cell_migration0.74765532
112MP0001905_abnormal_dopamine_level0.72810181
113MP0003183_abnormal_peptide_metabolism0.71633542
114MP0008872_abnormal_physiological_respon0.71496969
115MP0001299_abnormal_eye_distance/0.70579711
116MP0001963_abnormal_hearing_physiology0.70085767
117MP0000462_abnormal_digestive_system0.69879347
118MP0001765_abnormal_ion_homeostasis0.68636951
119MP0005409_darkened_coat_color0.68216037
120MP0005620_abnormal_muscle_contractility0.67434922
121MP0010630_abnormal_cardiac_muscle0.67283713
122MP0000747_muscle_weakness0.66759408
123MP0003950_abnormal_plasma_membrane0.66060323
124MP0005623_abnormal_meninges_morphology0.64196975
125MP0004142_abnormal_muscle_tone0.64086222
126MP0002234_abnormal_pharynx_morphology0.63443630
127MP0004036_abnormal_muscle_relaxation0.63392981
128MP0004510_myositis0.62857464
129MP0004215_abnormal_myocardial_fiber0.62290510
130MP0004233_abnormal_muscle_weight0.60273995

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.44830876
2Myokymia (HP:0002411)6.18995497
3Focal seizures (HP:0007359)4.80267199
4Visual hallucinations (HP:0002367)4.30809584
5Supranuclear gaze palsy (HP:0000605)4.18209827
6Action tremor (HP:0002345)4.17807719
7Neurofibrillary tangles (HP:0002185)3.93042036
8Cerebral inclusion bodies (HP:0100314)3.72209027
9Epileptic encephalopathy (HP:0200134)3.68914485
10Ankle clonus (HP:0011448)3.45140422
11Atonic seizures (HP:0010819)3.28887819
12Papilledema (HP:0001085)3.25297328
13Progressive cerebellar ataxia (HP:0002073)3.15510106
14Generalized tonic-clonic seizures (HP:0002069)3.14811216
15Intention tremor (HP:0002080)3.13938437
16Absence seizures (HP:0002121)3.13433614
17Dysmetria (HP:0001310)3.12686353
18Insidious onset (HP:0003587)3.12380514
19Termporal pattern (HP:0011008)3.12380514
20Impaired vibration sensation in the lower limbs (HP:0002166)3.09485133
21Depression (HP:0000716)3.03238472
22Poor eye contact (HP:0000817)2.99137614
23Dialeptic seizures (HP:0011146)2.94258752
24Urinary bladder sphincter dysfunction (HP:0002839)2.92332554
25Postural instability (HP:0002172)2.90741390
26Abnormal social behavior (HP:0012433)2.84280039
27Impaired social interactions (HP:0000735)2.84280039
28Cerebral aneurysm (HP:0004944)2.83844569
29Febrile seizures (HP:0002373)2.83086662
30Dysdiadochokinesis (HP:0002075)2.82090021
31Broad-based gait (HP:0002136)2.80564342
32Hyporeflexia of lower limbs (HP:0002600)2.75501679
33Abnormal eating behavior (HP:0100738)2.73507685
34Urinary urgency (HP:0000012)2.73032813
35Arterial tortuosity (HP:0005116)2.69274444
36Obstructive sleep apnea (HP:0002870)2.65530597
37Spastic gait (HP:0002064)2.65179223
38Truncal ataxia (HP:0002078)2.63382212
39Gaze-evoked nystagmus (HP:0000640)2.63258383
40Megalencephaly (HP:0001355)2.63110660
41Anxiety (HP:0000739)2.61254804
42Mutism (HP:0002300)2.59059718
43Akinesia (HP:0002304)2.56263507
44Hemiplegia (HP:0002301)2.50889982
45Vascular tortuosity (HP:0004948)2.50691652
46Lower limb muscle weakness (HP:0007340)2.49827261
47Protrusio acetabuli (HP:0003179)2.49692393
48Abnormality of the corticospinal tract (HP:0002492)2.47455385
49Hypoplasia of the iris (HP:0007676)2.46841747
50Ventricular fibrillation (HP:0001663)2.45990212
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43152480
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.43152480
53Amblyopia (HP:0000646)2.41700543
54Torticollis (HP:0000473)2.40373244
55Neuronal loss in central nervous system (HP:0002529)2.35779190
56Excessive salivation (HP:0003781)2.29150309
57Drooling (HP:0002307)2.29150309
58Stereotypic behavior (HP:0000733)2.26959712
59Scanning speech (HP:0002168)2.25946846
60Hemiparesis (HP:0001269)2.25154371
61Impaired smooth pursuit (HP:0007772)2.23188983
62Insomnia (HP:0100785)2.20631130
63Hyperventilation (HP:0002883)2.20329545
64Aplasia involving bones of the extremities (HP:0009825)2.19139745
65Aplasia involving bones of the upper limbs (HP:0009823)2.19139745
66Aplasia of the phalanges of the hand (HP:0009802)2.19139745
67Bundle branch block (HP:0011710)2.17616273
68Focal dystonia (HP:0004373)2.17062155
69Blue irides (HP:0000635)2.15841980
70Ocular albinism (HP:0001107)2.15361243
71Bradykinesia (HP:0002067)2.14453891
72Sudden death (HP:0001699)2.14219881
73Diplopia (HP:0000651)2.13827899
74Abnormality of binocular vision (HP:0011514)2.13827899
75Rapidly progressive (HP:0003678)2.13376351
76Hammertoe (HP:0001765)2.11153826
77Abnormality of the lower motor neuron (HP:0002366)2.10250093
78Resting tremor (HP:0002322)2.10024746
79Genetic anticipation (HP:0003743)2.09512467
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06044246
81Peripheral hypomyelination (HP:0007182)2.05537412
82Decreased motor nerve conduction velocity (HP:0003431)2.04966020
83Annular pancreas (HP:0001734)2.04903243
84Increased circulating renin level (HP:0000848)2.04171411
85Heterochromia iridis (HP:0001100)2.03349279
86Epileptiform EEG discharges (HP:0011182)2.02901498
87Pheochromocytoma (HP:0002666)2.01829321
88Impaired vibratory sensation (HP:0002495)2.01402088
89Abnormality of the periventricular white matter (HP:0002518)2.01234398
90Ankyloglossia (HP:0010296)1.99235623
91Difficulty running (HP:0009046)1.98432949
92Dysmetric saccades (HP:0000641)1.98158763
93Foot dorsiflexor weakness (HP:0009027)1.96202436
94Hypopigmentation of the fundus (HP:0007894)1.94828973
95Iris hypopigmentation (HP:0007730)1.94687600
96EEG with generalized epileptiform discharges (HP:0011198)1.93844440
97Hyperacusis (HP:0010780)1.93141586
98Gait ataxia (HP:0002066)1.92239992
99Clonus (HP:0002169)1.92062038
100Lower limb amyotrophy (HP:0007210)1.90986325
101Upper limb amyotrophy (HP:0009129)1.90012382
102Distal upper limb amyotrophy (HP:0007149)1.90012382
103Craniofacial dystonia (HP:0012179)1.89997129
104Macroorchidism (HP:0000053)1.88611300
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88379172
106Abnormality of ocular smooth pursuit (HP:0000617)1.87961575
107Spastic tetraparesis (HP:0001285)1.86534115
108Heart block (HP:0012722)1.86498859
109Bronchomalacia (HP:0002780)1.86349648
110Lower limb asymmetry (HP:0100559)1.85184870
111Hypsarrhythmia (HP:0002521)1.85104981
112Abnormal atrioventricular conduction (HP:0005150)1.84583227
113Pointed chin (HP:0000307)1.83895720
114Rigidity (HP:0002063)1.81490223
115Tetraplegia (HP:0002445)1.81252466
116Apathy (HP:0000741)1.81001770
117Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79819778
118Fetal akinesia sequence (HP:0001989)1.79552177
119Buphthalmos (HP:0000557)1.79504489
120Abnormality of the foot musculature (HP:0001436)1.78811277
121Abnormality of saccadic eye movements (HP:0000570)1.78752722
122Alacrima (HP:0000522)1.77079489
123Atrioventricular block (HP:0001678)1.76982808
124Turricephaly (HP:0000262)1.76743270
125Shallow orbits (HP:0000586)1.75532379
126White forelock (HP:0002211)1.74435396
127Abnormal EKG (HP:0003115)1.74266634
128Clumsiness (HP:0002312)1.73637825
129Agitation (HP:0000713)1.72679270
130Prolonged QT interval (HP:0001657)1.72490304
131Hand muscle atrophy (HP:0009130)1.72100307
132Abnormality of the left ventricular outflow tract (HP:0011103)1.71976559
133Subaortic stenosis (HP:0001682)1.71976559
134Incomplete penetrance (HP:0003829)1.71648804
135Progressive inability to walk (HP:0002505)1.71112014
136Vertebral arch anomaly (HP:0008438)1.70634123
137Muscle fiber splitting (HP:0003555)1.70213125
138Increased variability in muscle fiber diameter (HP:0003557)1.70193096
139Exercise-induced myalgia (HP:0003738)1.70169011
140Frequent falls (HP:0002359)1.70063981
141Onion bulb formation (HP:0003383)1.70001399
142Premature rupture of membranes (HP:0001788)1.69964110
143Mild short stature (HP:0003502)1.69814834
144Aqueductal stenosis (HP:0002410)1.68318461
145Inappropriate behavior (HP:0000719)1.66115008
146Hyperparathyroidism (HP:0000843)1.64930636
147Mitral stenosis (HP:0001718)1.64803995
148Skin nodule (HP:0200036)1.63846818
149Bowel incontinence (HP:0002607)1.63388429
150Ulnar bowing (HP:0003031)1.62872167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.44309928
2NTRK33.76684951
3MAP3K93.53721638
4PRKD32.95084136
5DAPK22.74888235
6KSR22.61012975
7LATS22.52874355
8PAK62.24339524
9MAP3K42.18534286
10RIPK42.08252278
11MINK12.06475436
12NTRK12.05267554
13CAMKK12.05178422
14MARK11.91143491
15MAP3K21.70878023
16NTRK21.56610431
17LMTK21.54188579
18CAMK1G1.53832657
19KSR11.53687538
20CDK51.52101001
21MAP2K41.44221717
22MAP2K71.36012651
23STK391.30370821
24DAPK11.27148517
25TYRO31.23781381
26MAP3K131.22047555
27TRIB31.21874580
28FGFR41.21320168
29RIPK11.21006201
30OXSR11.19532358
31STK381.15631811
32FGFR21.15189698
33TTN1.14403688
34UHMK11.13416276
35CAMK1D1.10935593
36FES1.09250156
37PRKCH1.06962428
38CDK121.05551657
39CAMKK21.05278754
40FGFR31.05152957
41PTK2B1.05057589
42RET1.03506271
43SGK4941.02208928
44SGK2231.02208928
45MAP3K121.01922950
46PRPF4B0.99389137
47EEF2K0.98965526
48GRK50.98025663
49PDPK10.96424227
50CAMK2G0.95607546
51CAMK10.94967002
52CDK190.93702851
53PHKG10.93568490
54PHKG20.93568490
55STK110.91684607
56CAMK2B0.90991533
57DMPK0.90475179
58PDK10.89769525
59PTK20.88764264
60MAPK100.85360168
61SIK20.85041435
62ARAF0.84769482
63LATS10.84359632
64CAMK2A0.82618494
65PNCK0.82155912
66PAK30.81902388
67MAP3K10.81232539
68TAOK10.79883271
69MARK20.79328836
70MST1R0.77733742
71PLK20.77180651
72FER0.76034771
73SGK30.74712606
74LIMK10.74164617
75PRKCG0.73419207
76SGK10.71870748
77PDGFRB0.71644761
78PKN20.70550352
79TNIK0.70373281
80MAPK120.69860339
81FGR0.69735940
82MAPK130.69721313
83WNK10.69568025
84MUSK0.69192364
85ALK0.67992105
86RAF10.67866980
87CDK150.66186318
88ROCK10.66020036
89ERBB20.65027573
90PINK10.64942566
91CDK180.64787867
92CDK140.64167129
93PIK3CA0.63739010
94SCYL20.63488187
95WNK40.61970180
96MOS0.61814871
97MAP3K70.61001326
98DDR20.59363155
99SGK20.59174965
100CAMK2D0.58586879
101BMX0.58557758
102MTOR0.58347404
103FYN0.57083933
104FRK0.57011964
105OBSCN0.56819073
106PDGFRA0.54626449
107CDK11A0.53289698
108CASK0.52708111
109DYRK1A0.52514678
110MAP2K10.52356929
111PAK20.52215032
112NEK60.51663503
113ICK0.51557350
114MAPKAPK50.49717753
115RPS6KA30.48607175
116MET0.48453378
117CDC42BPA0.48064583
118PRKCZ0.47520194
119PRKCE0.47382951
120PRKAA20.46601517
121CSNK1G20.46163816
122MAP3K60.45905032
123ROCK20.44600052
124RPS6KB10.43673460
125PRKAA10.43622515
126PRKD10.42084139
127DAPK30.41996094

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.52922946
2Synaptic vesicle cycle_Homo sapiens_hsa047212.41976663
3Long-term potentiation_Homo sapiens_hsa047202.38983335
4Circadian entrainment_Homo sapiens_hsa047132.38399695
5Olfactory transduction_Homo sapiens_hsa047402.34270186
6Salivary secretion_Homo sapiens_hsa049702.22414405
7Glutamatergic synapse_Homo sapiens_hsa047242.21535766
8GABAergic synapse_Homo sapiens_hsa047272.17443748
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16221344
10Morphine addiction_Homo sapiens_hsa050322.09624500
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08777532
12Amphetamine addiction_Homo sapiens_hsa050312.08029938
13Gastric acid secretion_Homo sapiens_hsa049712.02271322
14Insulin secretion_Homo sapiens_hsa049111.90928651
15Nitrogen metabolism_Homo sapiens_hsa009101.87360671
16Dopaminergic synapse_Homo sapiens_hsa047281.83963499
17Renin secretion_Homo sapiens_hsa049241.78477557
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74773420
19Cholinergic synapse_Homo sapiens_hsa047251.72819130
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66792073
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63058711
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56298323
23Oxytocin signaling pathway_Homo sapiens_hsa049211.52968716
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50596126
25Long-term depression_Homo sapiens_hsa047301.45887388
26Cocaine addiction_Homo sapiens_hsa050301.44456681
27Calcium signaling pathway_Homo sapiens_hsa040201.38235069
28GnRH signaling pathway_Homo sapiens_hsa049121.37703168
29Type II diabetes mellitus_Homo sapiens_hsa049301.34394419
30Taste transduction_Homo sapiens_hsa047421.33847915
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31160018
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28453599
33cAMP signaling pathway_Homo sapiens_hsa040241.27847464
34Gap junction_Homo sapiens_hsa045401.25289744
35Serotonergic synapse_Homo sapiens_hsa047261.24556047
36Estrogen signaling pathway_Homo sapiens_hsa049151.21265690
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21175471
38Glioma_Homo sapiens_hsa052141.16322342
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15308137
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12560437
41Pancreatic secretion_Homo sapiens_hsa049721.12170289
42Melanogenesis_Homo sapiens_hsa049161.10626965
43Histidine metabolism_Homo sapiens_hsa003401.08700023
44Vitamin B6 metabolism_Homo sapiens_hsa007501.07742733
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.03905124
46Thyroid hormone synthesis_Homo sapiens_hsa049181.03037160
47Axon guidance_Homo sapiens_hsa043601.02025085
48Adherens junction_Homo sapiens_hsa045201.01954583
49Dorso-ventral axis formation_Homo sapiens_hsa043201.00873493
50ErbB signaling pathway_Homo sapiens_hsa040120.99279000
51Collecting duct acid secretion_Homo sapiens_hsa049660.98181216
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.93011826
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92329675
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91777375
55ECM-receptor interaction_Homo sapiens_hsa045120.91249571
56Vibrio cholerae infection_Homo sapiens_hsa051100.90848842
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89273967
58Fatty acid biosynthesis_Homo sapiens_hsa000610.88649351
59Focal adhesion_Homo sapiens_hsa045100.88037957
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87067100
61VEGF signaling pathway_Homo sapiens_hsa043700.81338262
62PPAR signaling pathway_Homo sapiens_hsa033200.80352216
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79414306
64Dilated cardiomyopathy_Homo sapiens_hsa054140.78296518
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77372656
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77158020
67Choline metabolism in cancer_Homo sapiens_hsa052310.73722009
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72323198
69Arginine biosynthesis_Homo sapiens_hsa002200.72240101
70Circadian rhythm_Homo sapiens_hsa047100.70097019
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.69665534
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68990621
73Protein digestion and absorption_Homo sapiens_hsa049740.67537911
74Endocytosis_Homo sapiens_hsa041440.67074159
75Glucagon signaling pathway_Homo sapiens_hsa049220.66654164
76Inositol phosphate metabolism_Homo sapiens_hsa005620.65924070
77Arginine and proline metabolism_Homo sapiens_hsa003300.65461259
78Rap1 signaling pathway_Homo sapiens_hsa040150.65387216
79mTOR signaling pathway_Homo sapiens_hsa041500.64951602
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64312297
81Proteoglycans in cancer_Homo sapiens_hsa052050.63658554
82Renal cell carcinoma_Homo sapiens_hsa052110.63654927
83Oocyte meiosis_Homo sapiens_hsa041140.63306118
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.62707839
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.60412524
86Bile secretion_Homo sapiens_hsa049760.60066885
87MAPK signaling pathway_Homo sapiens_hsa040100.59887274
88* Neurotrophin signaling pathway_Homo sapiens_hsa047220.59549162
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58066347
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57981461
91Amoebiasis_Homo sapiens_hsa051460.57900110
92Cardiac muscle contraction_Homo sapiens_hsa042600.57822109
93beta-Alanine metabolism_Homo sapiens_hsa004100.56788476
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56667708
95Ras signaling pathway_Homo sapiens_hsa040140.56389281
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55753219
97Fatty acid metabolism_Homo sapiens_hsa012120.55650508
98Insulin signaling pathway_Homo sapiens_hsa049100.55198261
99Hippo signaling pathway_Homo sapiens_hsa043900.54195968
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52572904
101Tight junction_Homo sapiens_hsa045300.52483709
102Non-small cell lung cancer_Homo sapiens_hsa052230.52333939
103Mineral absorption_Homo sapiens_hsa049780.50623034
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49703228
105Endometrial cancer_Homo sapiens_hsa052130.49593085
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47686775
107Glycerolipid metabolism_Homo sapiens_hsa005610.47519178
108Prion diseases_Homo sapiens_hsa050200.45793476
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44786738
110AMPK signaling pathway_Homo sapiens_hsa041520.44438265
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.41570357
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41324739
113Phototransduction_Homo sapiens_hsa047440.41061895
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.40531670
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40350116
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40084346
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40003903
118Chemokine signaling pathway_Homo sapiens_hsa040620.39761628
119Platelet activation_Homo sapiens_hsa046110.39689585
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37094576
121Ovarian steroidogenesis_Homo sapiens_hsa049130.36754803
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35819445
123Wnt signaling pathway_Homo sapiens_hsa043100.34799910
124Insulin resistance_Homo sapiens_hsa049310.34490386

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