SOS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.65446172
2startle response (GO:0001964)5.48119668
3cellular protein complex localization (GO:0034629)5.24459487
4negative regulation of axon guidance (GO:1902668)5.04025282
5nuclear pore organization (GO:0006999)4.63289090
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.59007295
7regulation of axon guidance (GO:1902667)4.51999712
8protein localization to microtubule (GO:0035372)4.51487574
9pore complex assembly (GO:0046931)4.27966462
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03070076
11epithelial cell differentiation involved in kidney development (GO:0035850)3.98156673
12negative regulation of glycogen metabolic process (GO:0070874)3.92814332
13neuron cell-cell adhesion (GO:0007158)3.82136615
14pyrimidine nucleobase catabolic process (GO:0006208)3.78329191
15localization within membrane (GO:0051668)3.74049556
16synaptic vesicle maturation (GO:0016188)3.71654388
17synaptic transmission, glutamatergic (GO:0035249)3.65858482
18vocalization behavior (GO:0071625)3.49874768
19negative regulation of erythrocyte differentiation (GO:0045647)3.47652090
20glomerulus development (GO:0032835)3.43568287
21embryonic process involved in female pregnancy (GO:0060136)3.41484886
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.34482411
23glutamate receptor signaling pathway (GO:0007215)3.30955447
24histone H3-K36 demethylation (GO:0070544)3.30883893
25positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29783546
26eye photoreceptor cell differentiation (GO:0001754)3.28371835
27photoreceptor cell differentiation (GO:0046530)3.28371835
28regulation of axon extension involved in axon guidance (GO:0048841)3.25981858
29cytoplasmic microtubule organization (GO:0031122)3.22615903
30neuron recognition (GO:0008038)3.14775922
31definitive hemopoiesis (GO:0060216)3.14206229
32nucleus localization (GO:0051647)3.11850933
33dendrite morphogenesis (GO:0048813)3.08842760
34regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.07882778
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.05556764
36regulation of histone H3-K27 methylation (GO:0061085)3.05234142
37histone H3-K4 trimethylation (GO:0080182)3.04565624
38axonal fasciculation (GO:0007413)3.04385329
39cell migration in hindbrain (GO:0021535)2.99691133
40gamma-aminobutyric acid transport (GO:0015812)2.98600840
41cerebral cortex radially oriented cell migration (GO:0021799)2.94181928
42nucleobase catabolic process (GO:0046113)2.92745450
43neuron-neuron synaptic transmission (GO:0007270)2.92264161
44glutamate secretion (GO:0014047)2.92180741
45protein localization to microtubule cytoskeleton (GO:0072698)2.89297222
46positive regulation of gamma-delta T cell activation (GO:0046645)2.86538395
47regulation of synaptic vesicle exocytosis (GO:2000300)2.84956818
48nerve growth factor signaling pathway (GO:0038180)2.84678042
49regulation of RNA export from nucleus (GO:0046831)2.83540933
50protein complex localization (GO:0031503)2.83156718
51positive regulation of microtubule polymerization (GO:0031116)2.82801286
52synaptic vesicle endocytosis (GO:0048488)2.82561653
53interkinetic nuclear migration (GO:0022027)2.82476804
54presynaptic membrane assembly (GO:0097105)2.82237764
55protein localization to cytoskeleton (GO:0044380)2.81840510
56locomotory exploration behavior (GO:0035641)2.80462669
57regulation of sensory perception (GO:0051931)2.80042989
58regulation of sensory perception of pain (GO:0051930)2.80042989
59positive regulation of glycogen metabolic process (GO:0070875)2.79827081
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79107168
61monoubiquitinated protein deubiquitination (GO:0035520)2.78580200
62corticosteroid receptor signaling pathway (GO:0031958)2.78409966
63synaptic vesicle docking involved in exocytosis (GO:0016081)2.77892856
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76566590
65presynaptic membrane organization (GO:0097090)2.75963326
66behavioral response to cocaine (GO:0048148)2.74605322
67cerebellar Purkinje cell differentiation (GO:0021702)2.74035438
68neurotransmitter secretion (GO:0007269)2.73799829
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73554311
70layer formation in cerebral cortex (GO:0021819)2.72531153
71axon extension involved in axon guidance (GO:0048846)2.71685305
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.71685305
73neurotransmitter-gated ion channel clustering (GO:0072578)2.70659120
74establishment of nucleus localization (GO:0040023)2.67977369
75regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67891343
76neuromuscular junction development (GO:0007528)2.66803948
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66684797
78histone H3-K9 demethylation (GO:0033169)2.66508793
79response to interleukin-15 (GO:0070672)2.66502114
80negative regulation of neurotransmitter secretion (GO:0046929)2.66390091
81hypotonic response (GO:0006971)2.65861681
82ganglion development (GO:0061548)2.65730034
83NLS-bearing protein import into nucleus (GO:0006607)2.63137268
84establishment of mitochondrion localization (GO:0051654)2.61902991
85negative regulation of dendrite morphogenesis (GO:0050774)2.61737756
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61577496
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60562618
88carnitine shuttle (GO:0006853)2.59195429
89cytoplasmic mRNA processing body assembly (GO:0033962)2.58269165
90exploration behavior (GO:0035640)2.58006157
91axon extension (GO:0048675)2.57986482
92regulation of neuronal synaptic plasticity (GO:0048168)2.57980668
93stem cell division (GO:0017145)2.57601438
94regulation of glutamate receptor signaling pathway (GO:1900449)2.56912678
95histone lysine demethylation (GO:0070076)2.56121684
96peptidyl-threonine phosphorylation (GO:0018107)2.55828106
97dendritic spine morphogenesis (GO:0060997)2.55157979
98regulation of NFAT protein import into nucleus (GO:0051532)2.54050143
99regulation of glomerular filtration (GO:0003093)2.53243035
100cell differentiation involved in kidney development (GO:0061005)2.51840635
101cerebellar granule cell differentiation (GO:0021707)2.49658739
102pericardium development (GO:0060039)2.49521173
103regulation of nucleobase-containing compound transport (GO:0032239)2.48625728
104coronary vasculature morphogenesis (GO:0060977)2.47883416
105embryonic camera-type eye morphogenesis (GO:0048596)2.47829076
106neuromuscular process (GO:0050905)2.46584907
107synapse organization (GO:0050808)2.46401916
108regulation of synaptic vesicle transport (GO:1902803)2.45570408
109neuronal action potential propagation (GO:0019227)2.45270253
110regulation of transforming growth factor beta2 production (GO:0032909)2.44714215
111lipid translocation (GO:0034204)2.44362279
112phospholipid translocation (GO:0045332)2.44362279
113negative regulation of axonogenesis (GO:0050771)2.44291481
114peptidyl-threonine modification (GO:0018210)2.43569170
115histone demethylation (GO:0016577)2.42884822
116glucocorticoid receptor signaling pathway (GO:0042921)2.41794660
117negative regulation of dendrite development (GO:2000171)2.41150674
118postsynaptic membrane organization (GO:0001941)2.40497132
119protein localization to synapse (GO:0035418)2.39938082
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39776939
121proximal/distal pattern formation (GO:0009954)2.37619868
122synapse assembly (GO:0007416)2.37495404
123positive regulation of pseudopodium assembly (GO:0031274)2.36849469
124growth hormone receptor signaling pathway (GO:0060396)2.35497920
125peptidyl-lysine trimethylation (GO:0018023)2.35234008
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35212388
127synaptic vesicle exocytosis (GO:0016079)2.34162749
128positive regulation of granulocyte differentiation (GO:0030854)2.33872242
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33176459
130positive regulation of Rap GTPase activity (GO:0032854)2.32712467
131organelle transport along microtubule (GO:0072384)2.31271043
132cerebral cortex cell migration (GO:0021795)2.30714581
133positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29613316
134mitochondrion transport along microtubule (GO:0047497)2.29477501
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29477501
136positive regulation of synapse assembly (GO:0051965)2.28382449
137vesicle transport along microtubule (GO:0047496)2.28110297
138iron ion import (GO:0097286)2.27405113
139mating behavior (GO:0007617)2.27294998
140regulation of gamma-delta T cell differentiation (GO:0045586)2.27157234
141negative regulation of chemotaxis (GO:0050922)2.27119418
142synapsis (GO:0007129)2.26956074
143gastrulation with mouth forming second (GO:0001702)2.24423302
144regulation of establishment of cell polarity (GO:2000114)2.18765890
145cellular response to ethanol (GO:0071361)2.17871253
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.15692017
147artery development (GO:0060840)2.15627348
148embryonic hemopoiesis (GO:0035162)2.14787154
149lymphangiogenesis (GO:0001946)2.12887903
150Golgi to endosome transport (GO:0006895)2.12705856
151clathrin coat assembly (GO:0048268)2.10589689
152fatty acid transmembrane transport (GO:1902001)2.10577235
153regulation of Rap GTPase activity (GO:0032317)2.08714967
154establishment of protein localization to Golgi (GO:0072600)2.08162644
155embryonic foregut morphogenesis (GO:0048617)2.06441832
156mitotic sister chromatid cohesion (GO:0007064)2.06413122
157hepatocyte apoptotic process (GO:0097284)2.05656091
158histone H3-K4 methylation (GO:0051568)2.04431703
159cellular response to fluid shear stress (GO:0071498)2.03724120
160cell adhesion mediated by integrin (GO:0033627)2.03400126
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.02502058
162cellular response to growth hormone stimulus (GO:0071378)2.02309550
163embryonic eye morphogenesis (GO:0048048)2.01739812
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.01333970
165focal adhesion assembly (GO:0048041)2.01031727
166cell-substrate adherens junction assembly (GO:0007045)2.01031727
167cell-substrate junction assembly (GO:0007044)2.00513685
168cellular response to interleukin-15 (GO:0071350)2.00382729
169protein demethylation (GO:0006482)2.00199211
170protein dealkylation (GO:0008214)2.00199211
171positive regulation of insulin receptor signaling pathway (GO:0046628)1.99105344
172negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.98890027
173cellular extravasation (GO:0045123)1.97724683
174low-density lipoprotein particle clearance (GO:0034383)1.96984386
175response to epidermal growth factor (GO:0070849)1.96129234
176positive regulation of dendritic spine morphogenesis (GO:0061003)1.95861453
177positive regulation of extracellular matrix organization (GO:1903055)1.95646965
178regulation of gamma-delta T cell activation (GO:0046643)1.95477192
179regulation of pigment cell differentiation (GO:0050932)1.94287285
180protein targeting to Golgi (GO:0000042)1.92566452
181regulation of erythrocyte differentiation (GO:0045646)1.92408852
182histone lysine methylation (GO:0034968)1.92355263
183negative regulation of fatty acid transport (GO:2000192)1.92254916
184negative regulation of potassium ion transmembrane transport (GO:1901380)1.92182141
185regulation of cholesterol homeostasis (GO:2000188)1.91556222
186striated muscle atrophy (GO:0014891)1.91445159
187regulation of establishment or maintenance of cell polarity (GO:0032878)1.90518908
188labyrinthine layer development (GO:0060711)1.90502193
189regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.89760921
190morphogenesis of an epithelial sheet (GO:0002011)1.88950871
191negative T cell selection (GO:0043383)1.88864166
192regulation of granulocyte differentiation (GO:0030852)1.88766705
193regulation of extracellular matrix disassembly (GO:0010715)1.88236249
194early endosome to late endosome transport (GO:0045022)1.87322118
195pathway-restricted SMAD protein phosphorylation (GO:0060389)1.86518905
196DNA damage induced protein phosphorylation (GO:0006975)1.86289161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16639163
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07640160
3GBX2_23144817_ChIP-Seq_PC3_Human3.56613381
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95106393
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83723230
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.64898565
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59113245
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47996095
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45052319
10TAF15_26573619_Chip-Seq_HEK293_Human2.31936315
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28673409
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17801244
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15182154
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02670838
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02670838
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99034053
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94555084
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87594194
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87063329
20* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85072460
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.83477559
22RUNX_20019798_ChIP-Seq_JUKART_Human1.82606121
23GATA1_22025678_ChIP-Seq_K562_Human1.82327442
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76799280
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76744072
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.74901248
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74891045
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.73866474
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73863559
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70921429
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70707446
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70328875
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69434849
34SMAD4_21799915_ChIP-Seq_A2780_Human1.68796413
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68095761
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64908090
37REST_21632747_ChIP-Seq_MESCs_Mouse1.63525137
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.63522305
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.63058949
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.60980330
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60529099
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.58599577
43* STAT3_23295773_ChIP-Seq_U87_Human1.58180389
44DROSHA_22980978_ChIP-Seq_HELA_Human1.57619276
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.57548520
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57503972
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57472352
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.57098882
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56813311
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.54043059
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.52506423
52P300_19829295_ChIP-Seq_ESCs_Human1.52444251
53* FOXO3_23340844_ChIP-Seq_DLD1_Human1.51533462
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51243574
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50456854
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48531274
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.47111690
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45921847
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44343773
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44228772
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.43519841
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42731659
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.41701202
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.41138214
65* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40520079
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.39975330
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.39324487
68* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39166455
69IGF1R_20145208_ChIP-Seq_DFB_Human1.37842515
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37156882
71AR_21572438_ChIP-Seq_LNCaP_Human1.36028113
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35759484
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.35062622
74* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33863085
75TCF4_23295773_ChIP-Seq_U87_Human1.31995079
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31009798
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.30110143
78AR_25329375_ChIP-Seq_VCAP_Human1.29745113
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28811486
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27932580
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27384721
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27377708
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27377708
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26630099
85* AHR_22903824_ChIP-Seq_MCF-7_Human1.26391233
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26290467
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25923319
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24623709
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24196178
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.23081075
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19517292
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.19169034
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19084563
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19084563
95ER_23166858_ChIP-Seq_MCF-7_Human1.18164260
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17318550
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17174457
98SCL_19346495_ChIP-Seq_HPC-7_Human1.16495240
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15976273
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15862466
101RNF2_27304074_Chip-Seq_NSC_Mouse1.15140633
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14368151
103* RUNX2_22187159_ChIP-Seq_PCA_Human1.14315317
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13146155
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13104611
106* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13041610
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12888486
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12405632
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12238775
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11255486
111VDR_24787735_ChIP-Seq_THP-1_Human1.11064706
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10782625
113* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10428336
114GATA2_19941826_ChIP-Seq_K562_Human1.10378113
115AR_19668381_ChIP-Seq_PC3_Human1.10359738
116TP53_16413492_ChIP-PET_HCT116_Human1.10070449
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09451656
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.08599368
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.08057080
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.07992560
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.07294790
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07015438
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06828461
124BCAT_22108803_ChIP-Seq_LS180_Human1.05211093
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04726616
126SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04223415
127FUS_26573619_Chip-Seq_HEK293_Human1.03900382
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03752725
129STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03561168
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03249156
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03226392
132GATA1_19941826_ChIP-Seq_K562_Human1.02900787
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02875286
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.02857284
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02807445
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02173019
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.01263010
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.00741355
139REST_18959480_ChIP-ChIP_MESCs_Mouse1.00480825
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00408776
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99623407
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.99530456
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.99530456
144RXR_22108803_ChIP-Seq_LS180_Human0.99210028
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99188492
146BRD4_25478319_ChIP-Seq_HGPS_Human0.96965985
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96860456
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96798289
149TCF7_22412390_ChIP-Seq_EML_Mouse0.96570996
150CJUN_26792858_Chip-Seq_BT549_Human0.94636194
151IRF8_27001747_Chip-Seq_BMDM_Mouse0.94071833
152CMYC_18555785_Chip-Seq_ESCs_Mouse0.93741441
153* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93594719
154KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93349556
155CLOCK_20551151_ChIP-Seq_293T_Human0.92659492
156* ISL1_27105846_Chip-Seq_CPCs_Mouse0.91916742
157* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91657977
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.90877724
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.90686205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.43513851
2MP0003787_abnormal_imprinting3.95659664
3MP0003300_gastrointestinal_ulcer3.64221012
4MP0005248_abnormal_Harderian_gland3.50869339
5MP0004859_abnormal_synaptic_plasticity3.33348612
6MP0004270_analgesia3.16664938
7MP0008057_abnormal_DNA_replication3.05418707
8MP0003880_abnormal_central_pattern2.86292639
9MP0002009_preneoplasia2.76310403
10MP0005187_abnormal_penis_morphology2.70740520
11MP0003303_peritoneal_inflammation2.62418352
12MP0004185_abnormal_adipocyte_glucose2.56018679
13MP0003635_abnormal_synaptic_transmissio2.50461433
14MP0002139_abnormal_hepatobiliary_system2.49097206
15MP0005666_abnormal_adipose_tissue2.48670745
16MP0002396_abnormal_hematopoietic_system2.45708572
17MP0005085_abnormal_gallbladder_physiolo2.40658739
18MP0006276_abnormal_autonomic_nervous2.32113366
19MP0002909_abnormal_adrenal_gland2.27214127
20MP0005423_abnormal_somatic_nervous2.25153213
21MP0003705_abnormal_hypodermis_morpholog2.24460336
22MP0003763_abnormal_thymus_physiology2.22979179
23MP0002063_abnormal_learning/memory/cond2.20453688
24MP0008438_abnormal_cutaneous_collagen2.13644501
25MP0004130_abnormal_muscle_cell2.13503352
26MP0004264_abnormal_extraembryonic_tissu2.09287352
27MP0009745_abnormal_behavioral_response2.08663750
28MP0003122_maternal_imprinting2.06586032
29MP0002064_seizures1.98082357
30MP0003868_abnormal_feces_composition1.97229706
31MP0003121_genomic_imprinting1.94928962
32MP0010352_gastrointestinal_tract_polyps1.94346085
33MP0010386_abnormal_urinary_bladder1.93828345
34MP0001486_abnormal_startle_reflex1.90471606
35MP0009115_abnormal_fat_cell1.89626656
36MP0005275_abnormal_skin_tensile1.87932447
37MP0004858_abnormal_nervous_system1.83361964
38MP0004885_abnormal_endolymph1.83354860
39MP0005076_abnormal_cell_differentiation1.82325904
40MP0005375_adipose_tissue_phenotype1.78473821
41MP0000778_abnormal_nervous_system1.75063426
42MP0003566_abnormal_cell_adhesion1.73308121
43MP0003828_pulmonary_edema1.71442611
44MP0005646_abnormal_pituitary_gland1.71200466
45MP0001879_abnormal_lymphatic_vessel1.69484987
46MP0004808_abnormal_hematopoietic_stem1.69378710
47MP0003724_increased_susceptibility_to1.66290355
48MP0001968_abnormal_touch/_nociception1.65168887
49MP0002572_abnormal_emotion/affect_behav1.64820492
50MP0003091_abnormal_cell_migration1.64222548
51MP0009046_muscle_twitch1.63690369
52MP0004134_abnormal_chest_morphology1.61757250
53MP0002184_abnormal_innervation1.60527823
54MP0002734_abnormal_mechanical_nocicepti1.55438131
55MP0002735_abnormal_chemical_nociception1.54686481
56MP0008004_abnormal_stomach_pH1.53911819
57MP0003942_abnormal_urinary_system1.50628867
58MP0006138_congestive_heart_failure1.50507975
59MP0005365_abnormal_bile_salt1.48504363
60MP0001851_eye_inflammation1.47389038
61MP0002272_abnormal_nervous_system1.47332286
62MP0003943_abnormal_hepatobiliary_system1.46568247
63MP0003045_fibrosis1.45647431
64MP0002971_abnormal_brown_adipose1.45498692
65MP0004272_abnormal_basement_membrane1.45067618
66MP0001915_intracranial_hemorrhage1.43973875
67MP0000920_abnormal_myelination1.43880650
68MP0000647_abnormal_sebaceous_gland1.42822337
69MP0009780_abnormal_chondrocyte_physiolo1.39430458
70MP0005670_abnormal_white_adipose1.38932737
71MP0000767_abnormal_smooth_muscle1.38485833
72MP0009672_abnormal_birth_weight1.37313514
73MP0000569_abnormal_digit_pigmentation1.36850568
74MP0002067_abnormal_sensory_capabilities1.35134221
75MP0003183_abnormal_peptide_metabolism1.34091326
76MP0005360_urolithiasis1.33871559
77MP0002166_altered_tumor_susceptibility1.32538383
78MP0009703_decreased_birth_body1.30697153
79MP0004924_abnormal_behavior1.30181638
80MP0005386_behavior/neurological_phenoty1.30181638
81MP0002557_abnormal_social/conspecific_i1.29810845
82MP0000462_abnormal_digestive_system1.28934389
83* MP0010630_abnormal_cardiac_muscle1.28118577
84MP0002736_abnormal_nociception_after1.27602230
85MP0002108_abnormal_muscle_morphology1.27290248
86MP0006054_spinal_hemorrhage1.23915986
87MP0003937_abnormal_limbs/digits/tail_de1.23716996
88MP0010368_abnormal_lymphatic_system1.22513097
89MP0002925_abnormal_cardiovascular_devel1.17926480
90MP0002882_abnormal_neuron_morphology1.17695895
91MP0003385_abnormal_body_wall1.17480819
92MP0003656_abnormal_erythrocyte_physiolo1.17177668
93MP0002168_other_aberrant_phenotype1.16748936
94MP0003879_abnormal_hair_cell1.15693724
95MP0002733_abnormal_thermal_nociception1.15337412
96MP0000538_abnormal_urinary_bladder1.15333271
97MP0004883_abnormal_blood_vessel1.14799280
98MP0003252_abnormal_bile_duct1.14652465
99MP0003195_calcinosis1.14365912
100MP0000566_synostosis1.13861504
101MP0009053_abnormal_anal_canal1.12697037
102MP0004811_abnormal_neuron_physiology1.12401550
103MP0001440_abnormal_grooming_behavior1.11871445
104MP0001177_atelectasis1.11823179
105MP0003941_abnormal_skin_development1.11502179
106MP0005503_abnormal_tendon_morphology1.11118634
107MP0002877_abnormal_melanocyte_morpholog1.07910444
108MP0005451_abnormal_body_composition1.06579260
109MP0000003_abnormal_adipose_tissue1.06223801
110MP0002066_abnormal_motor_capabilities/c1.06152620
111* MP0002152_abnormal_brain_morphology1.05548405
112MP0000465_gastrointestinal_hemorrhage1.04172054
113MP0000955_abnormal_spinal_cord1.02588650
114MP0000537_abnormal_urethra_morphology1.02518128
115* MP0002086_abnormal_extraembryonic_tissu1.02320991
116MP0000428_abnormal_craniofacial_morphol1.01821737
117MP0001188_hyperpigmentation1.01232531
118MP0001958_emphysema1.00737947
119MP0009250_abnormal_appendicular_skeleto0.99798016
120MP0004147_increased_porphyrin_level0.99773291
121MP0005164_abnormal_response_to0.98837568
122MP0000534_abnormal_ureter_morphology0.97339672
123MP0001501_abnormal_sleep_pattern0.97068215
124MP0003279_aneurysm0.95665788
125MP0005171_absent_coat_pigmentation0.95004009
126MP0001970_abnormal_pain_threshold0.94701866
127MP0003115_abnormal_respiratory_system0.94104487
128MP0003861_abnormal_nervous_system0.94060381
129MP0003329_amyloid_beta_deposits0.93106160
130MP0000631_abnormal_neuroendocrine_gland0.92470838
131MP0002089_abnormal_postnatal_growth/wei0.92044881
132MP0000733_abnormal_muscle_development0.90063161
133MP0003984_embryonic_growth_retardation0.89727443
134MP0002088_abnormal_embryonic_growth/wei0.89698535
135MP0004133_heterotaxia0.89667871
136MP0005023_abnormal_wound_healing0.86731603
137MP0000639_abnormal_adrenal_gland0.86058620
138* MP0002128_abnormal_blood_circulation0.85427135
139MP0001666_abnormal_nutrient_absorption0.85238858
140MP0005464_abnormal_platelet_physiology0.84362338
141MP0004484_altered_response_of0.84030976
142MP0000703_abnormal_thymus_morphology0.82082889
143MP0003119_abnormal_digestive_system0.82032423
144* MP0000266_abnormal_heart_morphology0.81825511
145MP0000579_abnormal_nail_morphology0.81797899
146MP0003191_abnormal_cellular_cholesterol0.79735978
147MP0004087_abnormal_muscle_fiber0.77864687
148MP0002069_abnormal_eating/drinking_beha0.77464611
149MP0001984_abnormal_olfaction0.77276620
150* MP0001614_abnormal_blood_vessel0.76914258
151MP0004085_abnormal_heartbeat0.76775015
152MP0000432_abnormal_head_morphology0.75873784
153MP0002405_respiratory_system_inflammati0.75745444
154MP0003866_abnormal_defecation0.75701563
155MP0003221_abnormal_cardiomyocyte_apopto0.75340588
156MP0003890_abnormal_embryonic-extraembry0.74929283
157MP0003453_abnormal_keratinocyte_physiol0.74101305
158MP0010155_abnormal_intestine_physiology0.73913074
159MP0002998_abnormal_bone_remodeling0.73834725
160MP0001835_abnormal_antigen_presentation0.73231557
161MP0003948_abnormal_gas_homeostasis0.73126489
162MP0000383_abnormal_hair_follicle0.72011701
163MP0002896_abnormal_bone_mineralization0.71862971
164MP0005621_abnormal_cell_physiology0.71725260
165MP0004036_abnormal_muscle_relaxation0.71665302
166MP0009697_abnormal_copulation0.71606938
167MP0002752_abnormal_somatic_nervous0.71506652
168MP0010329_abnormal_lipoprotein_level0.71302216
169MP0002082_postnatal_lethality0.70713455
170MP0010770_preweaning_lethality0.70713455
171MP0001919_abnormal_reproductive_system0.69949248
172MP0003690_abnormal_glial_cell0.69925387
173MP0004084_abnormal_cardiac_muscle0.69717689
174MP0001784_abnormal_fluid_regulation0.69281921
175MP0001800_abnormal_humoral_immune0.69249387
176* MP0000249_abnormal_blood_vessel0.69076197
177MP0005334_abnormal_fat_pad0.69064213
178MP0003935_abnormal_craniofacial_develop0.68185329
179MP0002177_abnormal_outer_ear0.67970081
180MP0005623_abnormal_meninges_morphology0.67042737
181MP0005647_abnormal_sex_gland0.66686250
182MP0001299_abnormal_eye_distance/0.65978581

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)6.05217770
2Volvulus (HP:0002580)5.50473151
3Neoplasm of the adrenal cortex (HP:0100641)5.31903327
4Hypochromic microcytic anemia (HP:0004840)5.25552319
5Back pain (HP:0003418)4.25394716
6Stomach cancer (HP:0012126)4.16542191
7Epidermoid cyst (HP:0200040)4.13980155
8Subacute progressive viral hepatitis (HP:0006572)4.04525241
9Papillary thyroid carcinoma (HP:0002895)3.74787141
10Bell-shaped thorax (HP:0001591)3.74777429
11Focal motor seizures (HP:0011153)3.56795553
12Abnormality of the astrocytes (HP:0100707)3.44863837
13Astrocytoma (HP:0009592)3.44863837
14Colon cancer (HP:0003003)3.30213352
15Myelomeningocele (HP:0002475)3.21430854
16Bowel incontinence (HP:0002607)3.09798929
17Arterial tortuosity (HP:0005116)3.05769090
18Abnormal large intestine physiology (HP:0012700)2.96670675
19Glioma (HP:0009733)2.88636429
20Overgrowth (HP:0001548)2.87686468
21Vascular tortuosity (HP:0004948)2.84774807
22Absent frontal sinuses (HP:0002688)2.84103207
23Depressed nasal tip (HP:0000437)2.83154260
24Occipital encephalocele (HP:0002085)2.82948204
25Focal seizures (HP:0007359)2.80556287
26Adrenal hypoplasia (HP:0000835)2.78419155
27Heterotopia (HP:0002282)2.77504666
28Urethral obstruction (HP:0000796)2.73239768
29Drooling (HP:0002307)2.71610748
30Excessive salivation (HP:0003781)2.71610748
31Aortic aneurysm (HP:0004942)2.70751810
32Abnormal umbilical cord blood vessels (HP:0011403)2.67561642
33Single umbilical artery (HP:0001195)2.67561642
34Abnormality of the fetal cardiovascular system (HP:0010948)2.67561642
35Abnormality of the fingertips (HP:0001211)2.64861926
36Insidious onset (HP:0003587)2.55899040
37Termporal pattern (HP:0011008)2.55899040
38Acute myeloid leukemia (HP:0004808)2.52754568
39Narrow palate (HP:0000189)2.52280086
40Broad palm (HP:0001169)2.52162191
41Protruding tongue (HP:0010808)2.51477034
42Thyroid carcinoma (HP:0002890)2.50255621
43Vertebral arch anomaly (HP:0008438)2.50113849
44Action tremor (HP:0002345)2.49969579
45Leiomyosarcoma (HP:0100243)2.43920789
46Uterine leiomyosarcoma (HP:0002891)2.43920789
47Aortic dissection (HP:0002647)2.41570875
48Exotropia (HP:0000577)2.38520536
49Dislocated radial head (HP:0003083)2.35555200
50Hyperventilation (HP:0002883)2.35364244
51Flat acetabular roof (HP:0003180)2.35198883
52Febrile seizures (HP:0002373)2.34592694
53Difficulty running (HP:0009046)2.32619646
54Tented upper lip vermilion (HP:0010804)2.28498000
55Protrusio acetabuli (HP:0003179)2.27651722
56Abnormality of the nasal septum (HP:0000419)2.24612251
57Transitional cell carcinoma of the bladder (HP:0006740)2.22636296
58Epileptic encephalopathy (HP:0200134)2.21340461
59Hepatocellular carcinoma (HP:0001402)2.20221077
60Increased number of teeth (HP:0011069)2.19406182
61Spontaneous hematomas (HP:0007420)2.19230081
62Shawl scrotum (HP:0000049)2.18528005
63Supernumerary ribs (HP:0005815)2.17090660
64Atonic seizures (HP:0010819)2.15592969
65Syringomyelia (HP:0003396)2.15280617
66Spinal cord lesions (HP:0100561)2.15280617
67Long eyelashes (HP:0000527)2.14736679
68Mitral valve prolapse (HP:0001634)2.14096958
69Genetic anticipation (HP:0003743)2.13186496
70Abnormality of the radial head (HP:0003995)2.12461785
71Asymmetry of the thorax (HP:0001555)2.10123449
72Hyperthyroidism (HP:0000836)2.09357442
73Acanthocytosis (HP:0001927)2.09188356
74Neoplasm of the oral cavity (HP:0100649)2.08568173
75Dysmetric saccades (HP:0000641)2.08454781
76Truncal obesity (HP:0001956)2.08239202
77Hypoplastic nipples (HP:0002557)2.05906027
78Thick eyebrow (HP:0000574)2.03925525
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02506272
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01977934
81Neoplasm of the adrenal gland (HP:0100631)2.01680281
82Abnormality of the corticospinal tract (HP:0002492)1.99408089
83Inappropriate behavior (HP:0000719)1.98667668
84Oligodactyly (hands) (HP:0001180)1.98527721
85Progressive cerebellar ataxia (HP:0002073)1.98345807
86Deep philtrum (HP:0002002)1.97811148
87* Coarse hair (HP:0002208)1.97426190
88Scrotal hypoplasia (HP:0000046)1.96966976
89Multiple lipomas (HP:0001012)1.96609352
90Rectal prolapse (HP:0002035)1.95658745
91Bladder neoplasm (HP:0009725)1.95629171
92Bladder carcinoma (HP:0002862)1.95629171
93Tapered finger (HP:0001182)1.95376606
94Myokymia (HP:0002411)1.95091335
95Abnormality of the left ventricular outflow tract (HP:0011103)1.94016802
96Subaortic stenosis (HP:0001682)1.94016802
97Papilledema (HP:0001085)1.93900628
98Abnormality of the ischium (HP:0003174)1.93821235
99Thickened calvaria (HP:0002684)1.93737724
100Absence seizures (HP:0002121)1.93281003
101Medulloblastoma (HP:0002885)1.92467304
102Atelectasis (HP:0100750)1.91977569
103Hypoplasia of the brainstem (HP:0002365)1.91523353
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91523353
105Anophthalmia (HP:0000528)1.89063303
106Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88896035
107Abnormality of salivation (HP:0100755)1.88717582
108Abnormality of the labia minora (HP:0012880)1.88207706
109Renal hypoplasia (HP:0000089)1.86816359
110Arnold-Chiari malformation (HP:0002308)1.86640067
111Macroorchidism (HP:0000053)1.86596501
112Supernumerary bones of the axial skeleton (HP:0009144)1.86401541
113Peritonitis (HP:0002586)1.86086233
114T lymphocytopenia (HP:0005403)1.85836333
115Ulnar claw (HP:0001178)1.84506157
116Cupped ribs (HP:0000887)1.83684024
117Vesicoureteral reflux (HP:0000076)1.83627890
118Aneurysm (HP:0002617)1.82835663
119Neonatal hypoglycemia (HP:0001998)1.82386894
120Ankyloglossia (HP:0010296)1.82359880
121Gingival bleeding (HP:0000225)1.81851526
122Chronic hepatic failure (HP:0100626)1.81534636
123Infantile muscular hypotonia (HP:0008947)1.80949082
124Dialeptic seizures (HP:0011146)1.80719770
125Limb dystonia (HP:0002451)1.80230352
126Urinary bladder sphincter dysfunction (HP:0002839)1.79976712
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78887045
128Flared iliac wings (HP:0002869)1.78505000
129Abnormal foot bone ossification (HP:0010675)1.78312466
130Abnormality of the right ventricle (HP:0001707)1.77747743
131Generalized tonic-clonic seizures (HP:0002069)1.77579427
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77026697
133Low anterior hairline (HP:0000294)1.76017069
134Hypsarrhythmia (HP:0002521)1.75602737
135Delayed closure of the anterior fontanelle (HP:0001476)1.72533883
136Cerebral aneurysm (HP:0004944)1.71617372
137Abnormality of the peritoneum (HP:0002585)1.71113360
138Fibular hypoplasia (HP:0003038)1.71019642
139Limb hypertonia (HP:0002509)1.70415052
140Viral hepatitis (HP:0006562)1.69978586
141Relative macrocephaly (HP:0004482)1.69763420
142Deep venous thrombosis (HP:0002625)1.69382442
143EEG with generalized epileptiform discharges (HP:0011198)1.69003266
144Disproportionate tall stature (HP:0001519)1.68932619
145Epileptiform EEG discharges (HP:0011182)1.67676860
146Abnormality of the wing of the ilium (HP:0011867)1.66967330
147Gastroesophageal reflux (HP:0002020)1.66656885
148Hamartoma (HP:0010566)1.65851892
149Conjugated hyperbilirubinemia (HP:0002908)1.65253423
150Short tibia (HP:0005736)1.65131171
151Broad-based gait (HP:0002136)1.64730178
152Hypoplastic ischia (HP:0003175)1.64479094
153Cutis marmorata (HP:0000965)1.64362085
154Scanning speech (HP:0002168)1.64155161
155Ectopic anus (HP:0004397)1.63539713
156Cutaneous finger syndactyly (HP:0010554)1.63442575
157Abnormality of the frontal sinuses (HP:0002687)1.63296430
158Hypoplastic labia majora (HP:0000059)1.63162879
159Abnormal hair whorl (HP:0010721)1.62675279
160Torticollis (HP:0000473)1.62080572
161Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61934577
162Polycythemia (HP:0001901)1.60573408
163Wide nose (HP:0000445)1.60491108
164Conjunctival telangiectasia (HP:0000524)1.60135910
165Menstrual irregularities (HP:0000858)1.59657447
166Broad ribs (HP:0000885)1.58573176
167Right ventricular cardiomyopathy (HP:0011663)1.58438288
168Large earlobe (HP:0009748)1.56700651
169Neonatal short-limb short stature (HP:0008921)1.55848841
170Abnormality of the aortic arch (HP:0012303)1.55795391
171Abnormality of T cell number (HP:0011839)1.55393421
172Abnormality of incisor morphology (HP:0011063)1.54843444
173Limited elbow extension (HP:0001377)1.54719336
174Fair hair (HP:0002286)1.54359248
175Esophageal varix (HP:0002040)1.54261314
176Abnormality of the common coagulation pathway (HP:0010990)1.53945081
177Atrophic scars (HP:0001075)1.53846703
178Hemorrhage of the eye (HP:0011885)1.52850166
179Increased connective tissue (HP:0009025)1.52567850
180Sandal gap (HP:0001852)1.52467519
181Wide anterior fontanel (HP:0000260)1.51902476
182* Pulmonic stenosis (HP:0001642)1.51563549
183Spondylolisthesis (HP:0003302)1.51128206
184Eczematoid dermatitis (HP:0000976)1.50774950
185Abnormality of the distal phalanx of the thumb (HP:0009617)1.50650964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.57829825
2LATS14.42777985
3NTRK33.57071614
4CDK123.19406460
5CSNK1A1L2.94371820
6MARK12.90294028
7FGFR42.73738561
8CSNK1G32.57607314
9CSNK1G22.42183242
10RIPK12.36501763
11CASK2.13746057
12CSNK1G12.09238262
13JAK11.89867383
14PINK11.87620328
15MAP2K71.86935016
16MAP3K41.83885026
17PNCK1.83098292
18MINK11.74461209
19PIK3CA1.74053588
20NTRK21.70578969
21AKT31.67605621
22NUAK11.63509354
23RIPK41.61323132
24NLK1.61227479
25EEF2K1.60302405
26LATS21.50333539
27MAP2K41.49026251
28EPHA31.45437256
29TYK21.44462808
30INSRR1.44165371
31SGK21.42172375
32PDGFRB1.39874341
33SGK31.37153100
34PRPF4B1.36912953
35MAP3K101.36838271
36TRPM71.34883781
37TYRO31.33305673
38WNK11.26607917
39CAMK1D1.26097938
40SIK21.23408728
41SGK2231.22207047
42SGK4941.22207047
43MAPK131.19994070
44MARK21.17899463
45STK391.16657873
46TRIB31.12202246
47JAK31.10263392
48PLK21.08214664
49BMPR1B1.07518525
50IRAK21.03333764
51MAP3K71.03333097
52CAMK1G1.03280164
53DMPK1.01446363
54MAP2K60.99956328
55KSR20.98209043
56LMTK20.97662338
57NTRK10.97171393
58MELK0.96934215
59PKN20.96348770
60PRKCH0.96039627
61FGFR20.96005915
62DAPK20.94108826
63KSR10.94052759
64CDK60.93334451
65CDC42BPA0.90839839
66MAP3K90.89240585
67FRK0.84829177
68PTK60.84225986
69MAP3K140.84185488
70STK38L0.83795039
71PIK3CG0.82591691
72SIK30.81508929
73PAK60.81230657
74STK240.81208401
75STK30.80941978
76TEC0.78626723
77BCR0.78309699
78DDR20.77363922
79IRAK10.76923444
80ZAP700.76104267
81RET0.73788410
82ALK0.72708083
83MAP3K130.71973188
84HIPK20.71397153
85PDGFRA0.71391917
86CDK50.71045903
87ERBB40.69989136
88ERBB30.69561545
89BTK0.68911860
90PRKAA20.68831254
91MTOR0.68592979
92CSK0.68518559
93BMPR20.68309278
94JAK20.67974537
95EPHB10.66874260
96TTN0.66820487
97BRD40.65883674
98MAP3K10.64270263
99MAP3K60.62781213
100EPHA40.62763218
101ITK0.62159997
102RPS6KB20.60464753
103PKN10.58719626
104MAPK110.58181621
105FGFR10.58013604
106MAPK100.57877848
107ZAK0.56403799
108CSNK1A10.55499304
109GRK50.55441311
110PRKCG0.53890584
111RPS6KB10.53308902
112MAPK120.53138292
113RPS6KA30.53000842
114MAPK70.52855255
115RPS6KA20.51706975
116GRK60.51194179
117PRKD30.51035360
118FER0.50886935
119PRKG10.50788886
120MAP3K20.48548046
121CAMK2A0.48273169
122TAOK20.47567980
123CSNK1D0.47365020
124PLK30.47164881
125SGK10.46566445
126CDK70.46066407
127TGFBR20.45892878
128MAP4K20.45675906
129PDK10.45580161
130CSNK1E0.45488524
131MATK0.45331802
132CDK40.44755525
133DYRK20.44639146
134OXSR10.44032455
135STK380.43875660
136OBSCN0.43669592
137WNK40.43076394
138HCK0.41940842
139CAMK2B0.41531613
140PRKCE0.41502664
141MAP4K10.41283734
142STK110.40551349
143UHMK10.38820666
144YES10.38320148
145LCK0.38249182
146SIK10.38149339
147NEK90.37686139
148FGFR30.37427292
149PRKCB0.37236949
150MAP3K50.36207123
151MKNK20.33647644
152CAMKK10.33385510
153PAK30.33095417
154* GSK3B0.32565755
155NEK60.32563896
156TNIK0.32517553
157PHKG20.32050532
158PHKG10.32050532
159GRK70.31892220

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29336174
2Nitrogen metabolism_Homo sapiens_hsa009102.45080907
3Long-term potentiation_Homo sapiens_hsa047202.14189004
4Glutamatergic synapse_Homo sapiens_hsa047242.10632857
5Circadian entrainment_Homo sapiens_hsa047132.10015700
6Primary bile acid biosynthesis_Homo sapiens_hsa001201.97088069
7Amphetamine addiction_Homo sapiens_hsa050311.96700324
8Cocaine addiction_Homo sapiens_hsa050301.89105527
9GABAergic synapse_Homo sapiens_hsa047271.78845724
10* Endometrial cancer_Homo sapiens_hsa052131.72282570
11* Chronic myeloid leukemia_Homo sapiens_hsa052201.59918780
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58203357
13Taste transduction_Homo sapiens_hsa047421.58163283
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57522631
15* Non-small cell lung cancer_Homo sapiens_hsa052231.56669544
16Basal cell carcinoma_Homo sapiens_hsa052171.53880209
17Axon guidance_Homo sapiens_hsa043601.47831008
18* B cell receptor signaling pathway_Homo sapiens_hsa046621.46362355
19Synaptic vesicle cycle_Homo sapiens_hsa047211.46037721
20* Acute myeloid leukemia_Homo sapiens_hsa052211.45678179
21Pancreatic cancer_Homo sapiens_hsa052121.45335611
22Cholinergic synapse_Homo sapiens_hsa047251.44999112
23Arginine biosynthesis_Homo sapiens_hsa002201.43534013
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42495052
25* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41692824
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38673051
27Morphine addiction_Homo sapiens_hsa050321.37823701
28Dopaminergic synapse_Homo sapiens_hsa047281.36998596
29Insulin secretion_Homo sapiens_hsa049111.35331684
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33371725
31Platelet activation_Homo sapiens_hsa046111.32761843
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31298463
33Butanoate metabolism_Homo sapiens_hsa006501.28762909
34Salivary secretion_Homo sapiens_hsa049701.27589568
35Type II diabetes mellitus_Homo sapiens_hsa049301.25858874
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24865009
37* Focal adhesion_Homo sapiens_hsa045101.23013621
38Thyroid cancer_Homo sapiens_hsa052161.22402768
39* Jak-STAT signaling pathway_Homo sapiens_hsa046301.21145513
40* T cell receptor signaling pathway_Homo sapiens_hsa046601.19589886
41Insulin resistance_Homo sapiens_hsa049311.18854114
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18841074
43* MicroRNAs in cancer_Homo sapiens_hsa052061.17436103
44Serotonergic synapse_Homo sapiens_hsa047261.15615603
45Long-term depression_Homo sapiens_hsa047301.14647381
46* ErbB signaling pathway_Homo sapiens_hsa040121.14572129
47Bile secretion_Homo sapiens_hsa049761.13156768
48ECM-receptor interaction_Homo sapiens_hsa045121.12686533
49Osteoclast differentiation_Homo sapiens_hsa043801.12518822
50Vitamin B6 metabolism_Homo sapiens_hsa007501.09450316
51Notch signaling pathway_Homo sapiens_hsa043301.09122602
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07491788
53Measles_Homo sapiens_hsa051621.07258336
54Hepatitis B_Homo sapiens_hsa051611.05571963
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05565849
56Colorectal cancer_Homo sapiens_hsa052101.04392949
57* GnRH signaling pathway_Homo sapiens_hsa049121.03626574
58Small cell lung cancer_Homo sapiens_hsa052221.03491039
59Olfactory transduction_Homo sapiens_hsa047401.03319490
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.03235021
61* Dorso-ventral axis formation_Homo sapiens_hsa043201.02368097
62Adipocytokine signaling pathway_Homo sapiens_hsa049201.02013290
63Hedgehog signaling pathway_Homo sapiens_hsa043401.01713532
64cAMP signaling pathway_Homo sapiens_hsa040241.00577279
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00481731
66Toxoplasmosis_Homo sapiens_hsa051450.99146654
67TNF signaling pathway_Homo sapiens_hsa046680.98426289
68VEGF signaling pathway_Homo sapiens_hsa043700.97968260
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96594060
70Calcium signaling pathway_Homo sapiens_hsa040200.96543193
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96111347
72Circadian rhythm_Homo sapiens_hsa047100.96095988
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95810223
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95526584
75* Proteoglycans in cancer_Homo sapiens_hsa052050.95331491
76AMPK signaling pathway_Homo sapiens_hsa041520.93822565
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93416500
78* Glioma_Homo sapiens_hsa052140.93392884
79Gastric acid secretion_Homo sapiens_hsa049710.92376049
80Complement and coagulation cascades_Homo sapiens_hsa046100.92254244
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91922654
82Renin secretion_Homo sapiens_hsa049240.89317865
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89311234
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88686536
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88604143
86Influenza A_Homo sapiens_hsa051640.88280825
87Hippo signaling pathway_Homo sapiens_hsa043900.87794593
88* Hepatitis C_Homo sapiens_hsa051600.87660283
89* Estrogen signaling pathway_Homo sapiens_hsa049150.87606497
90Amoebiasis_Homo sapiens_hsa051460.87416243
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86911418
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86909316
93Wnt signaling pathway_Homo sapiens_hsa043100.86589247
94Tryptophan metabolism_Homo sapiens_hsa003800.79445345
95Lysine degradation_Homo sapiens_hsa003100.78908003
96Oxytocin signaling pathway_Homo sapiens_hsa049210.78669596
97* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78515845
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76962195
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.75983908
100* Chemokine signaling pathway_Homo sapiens_hsa040620.75426770
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74398412
102Malaria_Homo sapiens_hsa051440.74003589
103Dilated cardiomyopathy_Homo sapiens_hsa054140.73908430
104TGF-beta signaling pathway_Homo sapiens_hsa043500.73790565
105ABC transporters_Homo sapiens_hsa020100.73262367
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73158060
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72448203
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72262108
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72101202
110Melanogenesis_Homo sapiens_hsa049160.70935031
111* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70182151
112Glucagon signaling pathway_Homo sapiens_hsa049220.70149023
113* Pathways in cancer_Homo sapiens_hsa052000.70015662
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69405164
115HIF-1 signaling pathway_Homo sapiens_hsa040660.68920472
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68817928
117* Phospholipase D signaling pathway_Homo sapiens_hsa040720.67427697
118* Choline metabolism in cancer_Homo sapiens_hsa052310.67411326
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.67370037
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.66631623
121* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63437916
122Renin-angiotensin system_Homo sapiens_hsa046140.62091527
123African trypanosomiasis_Homo sapiens_hsa051430.61566467
124Fatty acid biosynthesis_Homo sapiens_hsa000610.60910204
125Inositol phosphate metabolism_Homo sapiens_hsa005620.59590411
126Glycerolipid metabolism_Homo sapiens_hsa005610.59493777
127* Insulin signaling pathway_Homo sapiens_hsa049100.58539126
128Leishmaniasis_Homo sapiens_hsa051400.58270300
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58130065
130Rap1 signaling pathway_Homo sapiens_hsa040150.58076819
131* MAPK signaling pathway_Homo sapiens_hsa040100.57632959
132* FoxO signaling pathway_Homo sapiens_hsa040680.57360023
133Pancreatic secretion_Homo sapiens_hsa049720.57118902
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.56965360
135PPAR signaling pathway_Homo sapiens_hsa033200.56035192
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55864456
137Hematopoietic cell lineage_Homo sapiens_hsa046400.55401467
138* Ras signaling pathway_Homo sapiens_hsa040140.54710913
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53685058
140* Gap junction_Homo sapiens_hsa045400.53441013
141Prion diseases_Homo sapiens_hsa050200.51706641
142Steroid biosynthesis_Homo sapiens_hsa001000.49074201
143mTOR signaling pathway_Homo sapiens_hsa041500.48619381
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47976982
145* Neurotrophin signaling pathway_Homo sapiens_hsa047220.47916360
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46913801
147Starch and sucrose metabolism_Homo sapiens_hsa005000.46758322
148* Prolactin signaling pathway_Homo sapiens_hsa049170.46696409
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.45898193
150* Renal cell carcinoma_Homo sapiens_hsa052110.45608226
151Adherens junction_Homo sapiens_hsa045200.43749914
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43024205
153* Prostate cancer_Homo sapiens_hsa052150.42907020
154beta-Alanine metabolism_Homo sapiens_hsa004100.42419883
155* Alcoholism_Homo sapiens_hsa050340.42170591
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40694965
157Ovarian steroidogenesis_Homo sapiens_hsa049130.40116303

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »