SOS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.57536511
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.12790289
3negative regulation of cell killing (GO:0031342)4.11948416
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11948416
5histone H3-K36 demethylation (GO:0070544)3.91444878
6macrophage activation involved in immune response (GO:0002281)3.70503627
7definitive hemopoiesis (GO:0060216)3.68594550
8regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.56566434
9regulation of B cell receptor signaling pathway (GO:0050855)3.54682772
10detection of external biotic stimulus (GO:0098581)3.48997464
11regulation of gamma-delta T cell activation (GO:0046643)3.48462220
12microglial cell activation (GO:0001774)3.47519686
13regulation of interferon-beta biosynthetic process (GO:0045357)3.36930662
14detection of other organism (GO:0098543)3.35660613
15macrophage activation (GO:0042116)3.29781996
16regulation of gamma-delta T cell differentiation (GO:0045586)3.29708901
17positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.25070452
18regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.25070452
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13173101
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.13173101
21regulation of translation, ncRNA-mediated (GO:0045974)3.13173101
22response to peptidoglycan (GO:0032494)3.12879413
23histone H3-K4 trimethylation (GO:0080182)3.11629476
24cytoplasmic mRNA processing body assembly (GO:0033962)3.06644553
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06305700
26response to host immune response (GO:0052572)3.06305700
27positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03746606
28phosphatidylinositol dephosphorylation (GO:0046856)3.03371384
29cellular extravasation (GO:0045123)3.02480448
30regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.01809999
31detection of biotic stimulus (GO:0009595)2.99609629
32positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93931155
33response to host (GO:0075136)2.93749293
34response to host defenses (GO:0052200)2.93749293
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93749293
36positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.91348664
37regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.91348664
38cellular response to ethanol (GO:0071361)2.91171964
39positive regulation of mRNA catabolic process (GO:0061014)2.85717364
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84123398
41dendritic cell migration (GO:0036336)2.82725629
42germinal center formation (GO:0002467)2.81276097
43T-helper cell differentiation (GO:0042093)2.80770326
44CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.80770326
45response to interleukin-15 (GO:0070672)2.79365617
46interferon-gamma production (GO:0032609)2.79023460
47dendritic cell chemotaxis (GO:0002407)2.77472046
48production of molecular mediator involved in inflammatory response (GO:0002532)2.77167497
49detection of bacterium (GO:0016045)2.75871695
50neutrophil activation (GO:0042119)2.74799130
51negative regulation of phagocytosis (GO:0050765)2.74456249
52somite development (GO:0061053)2.73199862
53B cell receptor signaling pathway (GO:0050853)2.72885005
54antigen processing and presentation of endogenous antigen (GO:0019883)2.72778358
55phospholipid dephosphorylation (GO:0046839)2.72692165
56neural tube formation (GO:0001841)2.70960608
57eye photoreceptor cell differentiation (GO:0001754)2.70731486
58photoreceptor cell differentiation (GO:0046530)2.70731486
59negative regulation of lymphocyte mediated immunity (GO:0002707)2.69874385
60regulation of somitogenesis (GO:0014807)2.69575898
61myeloid leukocyte mediated immunity (GO:0002444)2.68709008
62regulation of relaxation of muscle (GO:1901077)2.68649112
63macroautophagy (GO:0016236)2.67042954
64myelin maintenance (GO:0043217)2.66748009
65prostate gland growth (GO:0060736)2.65879760
66import into cell (GO:0098657)2.65267883
67negative regulation of neurotransmitter secretion (GO:0046929)2.64677937
68regulation of necroptotic process (GO:0060544)2.64251608
69regulation of DNA endoreduplication (GO:0032875)2.63155504
70regulation of mRNA catabolic process (GO:0061013)2.62494900
71positive regulation of histone deacetylation (GO:0031065)2.62097920
72cellular response to epinephrine stimulus (GO:0071872)2.61177820
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60506025
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60143727
75negative regulation of interleukin-12 production (GO:0032695)2.59303676
76negative regulation of T cell mediated immunity (GO:0002710)2.59151918
77phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.58707734
78muscle filament sliding (GO:0030049)2.58569983
79actin-myosin filament sliding (GO:0033275)2.58569983
80hepatocyte apoptotic process (GO:0097284)2.56079981
81sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54781333
82retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53541497
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51464602
84negative regulation of T-helper cell differentiation (GO:0045623)2.51464602
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.51308074
86activated T cell proliferation (GO:0050798)2.49254835
87negative regulation of erythrocyte differentiation (GO:0045647)2.49113900
88leukocyte migration involved in inflammatory response (GO:0002523)2.47625221
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46367790
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.45301855
91T cell differentiation involved in immune response (GO:0002292)2.44248843
92alpha-beta T cell differentiation involved in immune response (GO:0002293)2.44248843
93alpha-beta T cell activation involved in immune response (GO:0002287)2.44248843
94granulocyte activation (GO:0036230)2.43477571
95regulation of macrophage cytokine production (GO:0010935)2.43383488
96superoxide anion generation (GO:0042554)2.43174008
97negative regulation of Rho protein signal transduction (GO:0035024)2.42420460
98cellular response to interleukin-15 (GO:0071350)2.42123318
99peptidyl-lysine trimethylation (GO:0018023)2.42071935
100establishment of protein localization to Golgi (GO:0072600)2.40523263
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.39712814
102protein targeting to Golgi (GO:0000042)2.37186885
103mitotic sister chromatid cohesion (GO:0007064)2.36250753
104growth hormone receptor signaling pathway (GO:0060396)2.35765848
105myofibril assembly (GO:0030239)2.35071211
106actin-mediated cell contraction (GO:0070252)2.33704562
107response to epinephrine (GO:0071871)2.33336415
108negative regulation of myoblast differentiation (GO:0045662)2.32829131
109regulation of establishment of cell polarity (GO:2000114)2.31971191
110myeloid cell activation involved in immune response (GO:0002275)2.31006506
111actin filament-based movement (GO:0030048)2.29953472
112nerve growth factor signaling pathway (GO:0038180)2.29859448
113response to muramyl dipeptide (GO:0032495)2.29660854
114antigen processing and presentation via MHC class Ib (GO:0002475)2.29080607
115positive regulation of toll-like receptor signaling pathway (GO:0034123)2.28241530
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28087063
117response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.27727532
118interkinetic nuclear migration (GO:0022027)2.27289341
119regulation of germinal center formation (GO:0002634)2.26793373
120B cell homeostasis (GO:0001782)2.26505089
121megakaryocyte development (GO:0035855)2.26433779
122embryonic camera-type eye morphogenesis (GO:0048596)2.26160097
123positive T cell selection (GO:0043368)2.25923598
124positive regulation of Rap GTPase activity (GO:0032854)2.25091127
125embryonic hemopoiesis (GO:0035162)2.24864875
126neutrophil chemotaxis (GO:0030593)2.22772966
127I-kappaB phosphorylation (GO:0007252)2.22449479
128positive regulation of gamma-delta T cell activation (GO:0046645)2.22439298
129positive regulation of microtubule polymerization (GO:0031116)2.22282753
130negative regulation of granulocyte differentiation (GO:0030853)2.22184269
131leukocyte aggregation (GO:0070486)2.21712986
132skeletal muscle adaptation (GO:0043501)2.21712358
133neutrophil mediated immunity (GO:0002446)2.21112130
134histone H3-K4 methylation (GO:0051568)2.20874472
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.18421395
136neutrophil activation involved in immune response (GO:0002283)2.17954277
137neutrophil migration (GO:1990266)2.17947939
138skeletal muscle contraction (GO:0003009)2.17892794
139negative regulation of leukocyte mediated immunity (GO:0002704)2.17377904
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17273676
141cyclic nucleotide catabolic process (GO:0009214)2.16988046
142cellular response to growth hormone stimulus (GO:0071378)2.16802831
143muscle atrophy (GO:0014889)2.15401126
144response to lipoprotein particle (GO:0055094)2.14694756
145type B pancreatic cell development (GO:0003323)2.14415957
146modulation by symbiont of host defense response (GO:0052031)2.14301472
147modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14301472
148modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.14301472
149positive regulation by organism of defense response of other organism involved in symbiotic interact2.14301472
150modulation by symbiont of host immune response (GO:0052553)2.14301472
151positive regulation by symbiont of host defense response (GO:0052509)2.14301472
152interleukin-1-mediated signaling pathway (GO:0070498)2.14000379
153G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.12951876
154striated muscle atrophy (GO:0014891)2.12350940
155positive regulation of cellular amide metabolic process (GO:0034250)2.11609709
156peripheral nervous system axon ensheathment (GO:0032292)2.10433853
157myelination in peripheral nervous system (GO:0022011)2.10433853
158daunorubicin metabolic process (GO:0044597)2.09449819
159polyketide metabolic process (GO:0030638)2.09449819
160doxorubicin metabolic process (GO:0044598)2.09449819
161G-protein coupled receptor internalization (GO:0002031)2.09426388
162positive regulation of p38MAPK cascade (GO:1900745)2.05687777
163regulation of protein polyubiquitination (GO:1902914)2.04722288
164positive regulation of granulocyte differentiation (GO:0030854)2.04570975
165cell morphogenesis involved in neuron differentiation (GO:0048667)2.04410439
166CD4-positive, alpha-beta T cell activation (GO:0035710)2.04042169
167tyrosine phosphorylation of STAT protein (GO:0007260)2.01765846
168myelin assembly (GO:0032288)2.00856963
169negative regulation of B cell proliferation (GO:0030889)2.00472405
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021101.99787675
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)1.99787675
172histone lysine methylation (GO:0034968)1.99223701
173regulation of sarcomere organization (GO:0060297)1.98657338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13537955
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.70175828
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39446634
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51529604
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34707988
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23810233
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18804620
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17575200
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.12715995
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08819824
11IRF8_22096565_ChIP-ChIP_GC-B_Human1.98575868
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.94947933
13SCL_19346495_ChIP-Seq_HPC-7_Human1.94822045
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94173357
15RUNX_20019798_ChIP-Seq_JUKART_Human1.93005141
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.82226832
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81045725
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.72373842
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70279089
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67351271
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66331946
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.65499693
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64269506
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62710299
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62016527
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58248020
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58239623
28VDR_24787735_ChIP-Seq_THP-1_Human1.57497561
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.57114191
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54341685
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52654697
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48884140
33GATA1_22025678_ChIP-Seq_K562_Human1.45666958
34AHR_22903824_ChIP-Seq_MCF-7_Human1.41948128
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40891544
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.40723464
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.40365030
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39776968
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.38256007
40AR_21572438_ChIP-Seq_LNCaP_Human1.37657243
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.37215082
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35564616
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.34650869
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31871033
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31830886
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.29436643
47TP53_16413492_ChIP-PET_HCT116_Human1.28196205
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27797622
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.27044294
50ER_23166858_ChIP-Seq_MCF-7_Human1.26320441
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.25116835
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.24929471
53* PU_27001747_Chip-Seq_BMDM_Mouse1.23530772
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23381589
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21661229
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21661229
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21139245
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19573457
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18830815
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18422566
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18202644
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16324267
63STAT3_23295773_ChIP-Seq_U87_Human1.15992609
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.12804807
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12677062
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.12261817
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11741911
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11603684
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10696689
70* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09478996
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09453349
72SPI1_23127762_ChIP-Seq_K562_Human1.09308195
73TCF4_23295773_ChIP-Seq_U87_Human1.08886194
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08579847
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08481826
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.08470363
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.07773090
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.07715198
79P53_22387025_ChIP-Seq_ESCs_Mouse1.07256196
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07222970
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.06878346
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06871096
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06871096
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.05515379
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05173570
86SMAD4_21799915_ChIP-Seq_A2780_Human1.04813765
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04734504
88ZFX_18555785_Chip-Seq_ESCs_Mouse1.03608921
89P300_18555785_Chip-Seq_ESCs_Mouse1.03571437
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01931795
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01916566
92GATA3_27048872_Chip-Seq_THYMUS_Human1.01771142
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00891281
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00696912
95GATA2_19941826_ChIP-Seq_K562_Human1.00541673
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00526373
97GBX2_23144817_ChIP-Seq_PC3_Human1.00453921
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99943606
99PU1_27457419_Chip-Seq_LIVER_Mouse0.99007211
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98559922
101TP63_23658742_ChIP-Seq_EP156T_Human0.98410503
102* MYB_26560356_Chip-Seq_TH1_Human0.98402229
103RXR_22108803_ChIP-Seq_LS180_Human0.98208001
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97509016
105OCT4_18555785_Chip-Seq_ESCs_Mouse0.97156482
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96824013
107* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95866439
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95780112
109MYB_26560356_Chip-Seq_TH2_Human0.95776921
110EWS_26573619_Chip-Seq_HEK293_Human0.95711829
111CJUN_26792858_Chip-Seq_BT549_Human0.95554694
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95547374
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94608707
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.94326101
115BRD4_25478319_ChIP-Seq_HGPS_Human0.94084657
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.93979092
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93220528
118VDR_24763502_ChIP-Seq_THP-1_Human0.92960422
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92795420
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.92484094
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.92479887
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.92479887
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91752268
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.88119221
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87548920
126TCF7_22412390_ChIP-Seq_EML_Mouse0.87308580
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85814451
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84518173
129GATA1_19941826_ChIP-Seq_K562_Human0.83590604
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83315805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.37479330
2MP0003300_gastrointestinal_ulcer3.26988391
3MP0005171_absent_coat_pigmentation2.91936698
4MP0002009_preneoplasia2.72475090
5MP0005451_abnormal_body_composition2.65901137
6MP0000569_abnormal_digit_pigmentation2.47150718
7MP0002166_altered_tumor_susceptibility2.43150156
8MP0004130_abnormal_muscle_cell2.39642715
9MP0002396_abnormal_hematopoietic_system2.33444154
10MP0003045_fibrosis2.32634671
11MP0002138_abnormal_hepatobiliary_system2.32583464
12MP0003191_abnormal_cellular_cholesterol2.22028496
13MP0002332_abnormal_exercise_endurance2.09251428
14MP0003646_muscle_fatigue2.07230004
15MP0001873_stomach_inflammation2.03880031
16MP0005409_darkened_coat_color1.98185792
17MP0002928_abnormal_bile_duct1.85276011
18MP0002006_tumorigenesis1.84817488
19MP0002877_abnormal_melanocyte_morpholog1.84756515
20MP0001879_abnormal_lymphatic_vessel1.84031193
21MP0003950_abnormal_plasma_membrane1.83822144
22MP0009278_abnormal_bone_marrow1.74182419
23MP0003656_abnormal_erythrocyte_physiolo1.72311406
24MP0000749_muscle_degeneration1.72198568
25MP0000383_abnormal_hair_follicle1.71964277
26MP0001851_eye_inflammation1.70060340
27MP0004883_abnormal_blood_vessel1.68787124
28MP0000920_abnormal_myelination1.61355994
29MP0000733_abnormal_muscle_development1.61078640
30MP0005671_abnormal_response_to1.58392246
31MP0004510_myositis1.58208464
32MP0003828_pulmonary_edema1.58168243
33MP0010678_abnormal_skin_adnexa1.48524562
34MP0010307_abnormal_tumor_latency1.47131281
35MP0009785_altered_susceptibility_to1.47000042
36MP0008260_abnormal_autophagy1.46093496
37MP0008995_early_reproductive_senescence1.43537752
38MP0002971_abnormal_brown_adipose1.40024312
39MP0003091_abnormal_cell_migration1.38618254
40MP0002419_abnormal_innate_immunity1.38135272
41MP0005387_immune_system_phenotype1.37403060
42MP0001790_abnormal_immune_system1.37403060
43MP0003221_abnormal_cardiomyocyte_apopto1.36255900
44MP0004381_abnormal_hair_follicle1.34276463
45MP0004808_abnormal_hematopoietic_stem1.32303033
46MP0004087_abnormal_muscle_fiber1.28125558
47MP0002106_abnormal_muscle_physiology1.27083500
48MP0002452_abnormal_antigen_presenting1.27034771
49MP0005248_abnormal_Harderian_gland1.25565517
50MP0001800_abnormal_humoral_immune1.25323569
51MP0005645_abnormal_hypothalamus_physiol1.23887997
52MP0000465_gastrointestinal_hemorrhage1.23310171
53MP0000751_myopathy1.22805362
54MP0002420_abnormal_adaptive_immunity1.22306298
55MP0003941_abnormal_skin_development1.22189801
56MP0001819_abnormal_immune_cell1.21764183
57MP0002998_abnormal_bone_remodeling1.20907919
58MP0001533_abnormal_skeleton_physiology1.20083911
59MP0005164_abnormal_response_to1.18946227
60MP0002933_joint_inflammation1.18556607
61MP0005058_abnormal_lysosome_morphology1.17281273
62MP0002723_abnormal_immune_serum1.17261537
63MP0001835_abnormal_antigen_presentation1.16729125
64MP0003690_abnormal_glial_cell1.15668579
65MP0002405_respiratory_system_inflammati1.14557295
66MP0010352_gastrointestinal_tract_polyps1.13255083
67MP0009697_abnormal_copulation1.13240627
68MP0002277_abnormal_respiratory_mucosa1.13187655
69MP0005620_abnormal_muscle_contractility1.12988006
70MP0000003_abnormal_adipose_tissue1.11587487
71MP0010234_abnormal_vibrissa_follicle1.11465088
72MP0000759_abnormal_skeletal_muscle1.11375202
73MP0005666_abnormal_adipose_tissue1.11116339
74MP0009115_abnormal_fat_cell1.10757376
75MP0003436_decreased_susceptibility_to1.09108635
76MP0003943_abnormal_hepatobiliary_system1.09060255
77MP0001545_abnormal_hematopoietic_system1.07682711
78MP0005397_hematopoietic_system_phenotyp1.07682711
79MP0006138_congestive_heart_failure1.07396464
80MP0002972_abnormal_cardiac_muscle1.06993953
81MP0005464_abnormal_platelet_physiology1.06290818
82MP0000747_muscle_weakness1.06158063
83MP0004484_altered_response_of1.05982849
84MP0010155_abnormal_intestine_physiology1.05826834
85MP0000613_abnormal_salivary_gland1.05748424
86MP0003724_increased_susceptibility_to1.04157148
87MP0008004_abnormal_stomach_pH1.04149049
88MP0003172_abnormal_lysosome_physiology1.03433484
89MP0004947_skin_inflammation1.03352741
90MP0002269_muscular_atrophy1.03271597
91MP0005166_decreased_susceptibility_to1.01017816
92MP0010630_abnormal_cardiac_muscle1.00850681
93MP0005174_abnormal_tail_pigmentation1.00554825
94MP0005000_abnormal_immune_tolerance0.99355227
95MP0001188_hyperpigmentation0.98666449
96MP0003866_abnormal_defecation0.98172383
97MP0002148_abnormal_hypersensitivity_rea0.97801375
98MP0004145_abnormal_muscle_electrophysio0.97655206
99MP0001845_abnormal_inflammatory_respons0.96753320
100MP0000516_abnormal_urinary_system0.96361841
101MP0005367_renal/urinary_system_phenotyp0.96361841
102MP0000372_irregular_coat_pigmentation0.96297257
103MP0002127_abnormal_cardiovascular_syste0.93889820
104MP0002398_abnormal_bone_marrow0.93889274
105MP0003763_abnormal_thymus_physiology0.93302780
106MP0003303_peritoneal_inflammation0.93209352
107MP0000716_abnormal_immune_system0.92855029
108MP0005646_abnormal_pituitary_gland0.91918792
109MP0000470_abnormal_stomach_morphology0.91514491
110MP0005310_abnormal_salivary_gland0.91469797
111MP0001958_emphysema0.90565320
112MP0008057_abnormal_DNA_replication0.90133199
113MP0000249_abnormal_blood_vessel0.89878066
114MP0005025_abnormal_response_to0.89103760
115MP0002108_abnormal_muscle_morphology0.88651992
116MP0002168_other_aberrant_phenotype0.87992036
117MP0001346_abnormal_lacrimal_gland0.87987218
118MP0004185_abnormal_adipocyte_glucose0.87333457
119MP0003453_abnormal_keratinocyte_physiol0.86929229
120MP0001986_abnormal_taste_sensitivity0.86479686
121MP0002095_abnormal_skin_pigmentation0.85332520
122MP0004084_abnormal_cardiac_muscle0.84658159
123MP0000015_abnormal_ear_pigmentation0.84160935
124MP0003252_abnormal_bile_duct0.83237273
125MP0003121_genomic_imprinting0.83141276
126MP0000703_abnormal_thymus_morphology0.83037107
127MP0003183_abnormal_peptide_metabolism0.82605251
128MP0009764_decreased_sensitivity_to0.81406182
129MP0005375_adipose_tissue_phenotype0.79943210
130MP0004036_abnormal_muscle_relaxation0.79925744
131MP0005076_abnormal_cell_differentiation0.79628540
132MP0000371_diluted_coat_color0.79447765
133MP0003075_altered_response_to0.78780564
134MP0004742_abnormal_vestibular_system0.77949215
135MP0002925_abnormal_cardiovascular_devel0.77376795
136MP0006082_CNS_inflammation0.77168306
137MP0009703_decreased_birth_body0.76772550
138MP0000689_abnormal_spleen_morphology0.75919042
139MP0002722_abnormal_immune_system0.75867951
140MP0000685_abnormal_immune_system0.74340737
141MP0005369_muscle_phenotype0.74292733
142MP0000767_abnormal_smooth_muscle0.74242694

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.74579307
2Exercise-induced myalgia (HP:0003738)3.68454546
3Papillary thyroid carcinoma (HP:0002895)3.32935534
4Macroorchidism (HP:0000053)3.25187935
5Muscle fiber splitting (HP:0003555)3.15850951
6Subacute progressive viral hepatitis (HP:0006572)3.10099584
7Type 1 muscle fiber predominance (HP:0003803)2.86672207
8Abnormality of the nasal septum (HP:0000419)2.82761903
9Lip pit (HP:0100267)2.81233397
10Recurrent gram-negative bacterial infections (HP:0005420)2.78913331
11Gastrointestinal infarctions (HP:0005244)2.75697795
12Acute myeloid leukemia (HP:0004808)2.69009992
13Stomach cancer (HP:0012126)2.68783851
14EMG: myopathic abnormalities (HP:0003458)2.68768283
15Distal arthrogryposis (HP:0005684)2.68622400
16Prostate neoplasm (HP:0100787)2.64500114
17Aqueductal stenosis (HP:0002410)2.57747600
18Volvulus (HP:0002580)2.57243853
19Frequent falls (HP:0002359)2.51481840
20Asymmetric septal hypertrophy (HP:0001670)2.50432370
21Recurrent abscess formation (HP:0002722)2.47704409
22Recurrent skin infections (HP:0001581)2.47640081
23Spinal cord lesions (HP:0100561)2.45153551
24Syringomyelia (HP:0003396)2.45153551
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45135679
26White forelock (HP:0002211)2.44393158
27T lymphocytopenia (HP:0005403)2.43578114
28Chest pain (HP:0100749)2.41684219
29Retrobulbar optic neuritis (HP:0100654)2.40171574
30Optic neuritis (HP:0100653)2.40171574
31Stomatitis (HP:0010280)2.39655976
32Hypoplasia of the iris (HP:0007676)2.34169220
33Keratoconjunctivitis sicca (HP:0001097)2.33856884
34Hematochezia (HP:0002573)2.32982010
35Gingival bleeding (HP:0000225)2.30372475
36Abnormality of T cell number (HP:0011839)2.27709232
37Exercise-induced muscle cramps (HP:0003710)2.27345444
38Abnormality of skeletal muscle fiber size (HP:0012084)2.25833501
39Chronic diarrhea (HP:0002028)2.25608793
40Spontaneous hematomas (HP:0007420)2.24010647
41Bundle branch block (HP:0011710)2.23749540
42Chromsome breakage (HP:0040012)2.23322878
43Asymmetry of the thorax (HP:0001555)2.21938166
44Keratoconjunctivitis (HP:0001096)2.20587795
45Recurrent bacterial skin infections (HP:0005406)2.20392279
46Thyroiditis (HP:0100646)2.20334804
47Recurrent cutaneous fungal infections (HP:0011370)2.18874118
48Chronic mucocutaneous candidiasis (HP:0002728)2.18874118
49Peritonitis (HP:0002586)2.16994465
50Abnormality of the renal collecting system (HP:0004742)2.16426113
51Submucous cleft hard palate (HP:0000176)2.16102077
52Abnormality of incisor morphology (HP:0011063)2.15912289
53Congenital sensorineural hearing impairment (HP:0008527)2.14947295
54Spondylolisthesis (HP:0003302)2.14000925
55Increased variability in muscle fiber diameter (HP:0003557)2.13341732
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12970676
57Viral hepatitis (HP:0006562)2.12079781
58Eczematoid dermatitis (HP:0000976)2.10707441
59Patchy hypopigmentation of hair (HP:0011365)2.09499608
60Hypothermia (HP:0002045)2.08570011
61Abnormality of the calf musculature (HP:0001430)2.07583405
62Recurrent fungal infections (HP:0002841)2.05927397
63Facial diplegia (HP:0001349)2.05915527
64Hyporeflexia of lower limbs (HP:0002600)2.04083477
65Obstructive lung disease (HP:0006536)2.00426672
66Chronic obstructive pulmonary disease (HP:0006510)2.00426672
67Stenosis of the external auditory canal (HP:0000402)1.99844495
68EMG: neuropathic changes (HP:0003445)1.99224997
69Abnormal delayed hypersensitivity skin test (HP:0002963)1.98409638
70Thyroid carcinoma (HP:0002890)1.97876640
71Hypoplastic ischia (HP:0003175)1.97830426
72Neck muscle weakness (HP:0000467)1.97364114
73Long clavicles (HP:0000890)1.97299171
74Transitional cell carcinoma of the bladder (HP:0006740)1.96984655
75Increased connective tissue (HP:0009025)1.95691808
76Mediastinal lymphadenopathy (HP:0100721)1.95687610
77Papilledema (HP:0001085)1.95565196
78Absent frontal sinuses (HP:0002688)1.94635849
79Difficulty running (HP:0009046)1.94379859
80Premature skin wrinkling (HP:0100678)1.93926058
81Aplasia cutis congenita (HP:0001057)1.93506333
82Hyperkalemia (HP:0002153)1.93504515
83Mask-like facies (HP:0000298)1.93147936
84Subaortic stenosis (HP:0001682)1.92508359
85Abnormality of the left ventricular outflow tract (HP:0011103)1.92508359
86Muscle hypertrophy of the lower extremities (HP:0008968)1.90145442
87Bladder neoplasm (HP:0009725)1.88974304
88Bladder carcinoma (HP:0002862)1.88974304
89Fatigue (HP:0012378)1.88561799
90Tapered finger (HP:0001182)1.87170441
91Increased CSF protein (HP:0002922)1.87022690
92Vasculitis (HP:0002633)1.86443940
93Sudden death (HP:0001699)1.85356890
94Prolonged bleeding time (HP:0003010)1.85010589
95Hemoptysis (HP:0002105)1.84889582
96Orchitis (HP:0100796)1.84352297
97Truncal obesity (HP:0001956)1.83235335
98Long eyelashes (HP:0000527)1.82411554
99Thick eyebrow (HP:0000574)1.82017315
100Ectopic kidney (HP:0000086)1.81710234
101Cranial hyperostosis (HP:0004437)1.80723948
102Ectropion (HP:0000656)1.80714106
103Insulin-resistant diabetes mellitus (HP:0000831)1.80003130
104Abnormality of the endocardium (HP:0004306)1.78967440
105Overgrowth (HP:0001548)1.78424276
106Meningitis (HP:0001287)1.76671836
107Curly hair (HP:0002212)1.76145767
108Nemaline bodies (HP:0003798)1.75826086
109Ulnar deviation of the wrist (HP:0003049)1.75504085
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75263478
111Midline defect of the nose (HP:0004122)1.75050190
112Periodontitis (HP:0000704)1.74450461
113Abnormality of polysaccharide metabolism (HP:0011012)1.74351615
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74351615
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74351615
116Muscle fiber inclusion bodies (HP:0100299)1.73810555
117Abnormality of the frontal sinuses (HP:0002687)1.72921339
118Bell-shaped thorax (HP:0001591)1.72700003
119Thick nail (HP:0001805)1.72165164
120Abnormality of the prostate (HP:0008775)1.71169031
121Areflexia of lower limbs (HP:0002522)1.70996579
122Fair hair (HP:0002286)1.70680318
123Recurrent viral infections (HP:0004429)1.70668949
124Abnormality of the hepatic vasculature (HP:0006707)1.70480254
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.70122847
126Weak cry (HP:0001612)1.69839430
127Portal hypertension (HP:0001409)1.68946298
128Neoplasm of the tracheobronchial system (HP:0100552)1.68940207
129Abnormality of macrophages (HP:0004311)1.68925151
130Ventricular fibrillation (HP:0001663)1.68451198
131Blue irides (HP:0000635)1.67744603
132Gingivitis (HP:0000230)1.67654475
133Myositis (HP:0100614)1.66845590
134Supernumerary ribs (HP:0005815)1.66659942
135Cupped ear (HP:0000378)1.66090985
136Amyloidosis (HP:0011034)1.65623031
137Synophrys (HP:0000664)1.65555689
138Pulmonary infiltrates (HP:0002113)1.65419653
139Slow saccadic eye movements (HP:0000514)1.65240380
140Microvesicular hepatic steatosis (HP:0001414)1.64570827
141Ventricular tachycardia (HP:0004756)1.64525932
142Thickened calvaria (HP:0002684)1.64295849
143Episodic fever (HP:0001954)1.63454144
144Calf muscle hypertrophy (HP:0008981)1.63039214
145Ventricular arrhythmia (HP:0004308)1.62468875
146Widely spaced teeth (HP:0000687)1.62355041
147Osteolytic defects of the hand bones (HP:0009699)1.62067790
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.62067790
149Hypochromic microcytic anemia (HP:0004840)1.61970214
150Epistaxis (HP:0000421)1.61856350
151Arterial tortuosity (HP:0005116)1.61783926
152Acute lymphatic leukemia (HP:0006721)1.61472592
153Persistence of primary teeth (HP:0006335)1.61058557
154Abnormality of cochlea (HP:0000375)1.60967470
155Encephalitis (HP:0002383)1.60760109
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60404580
157Urticaria (HP:0001025)1.60372526
158Elevated erythrocyte sedimentation rate (HP:0003565)1.60143698
159Distal lower limb amyotrophy (HP:0008944)1.59852953
160Prominent nose (HP:0000448)1.59414002
161Duplicated collecting system (HP:0000081)1.59409451
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58357828
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58259251
164Broad face (HP:0000283)1.57229590
165Arterial thrombosis (HP:0004420)1.55415926
166Neoplasm of the adrenal cortex (HP:0100641)1.55303910
167Osteomyelitis (HP:0002754)1.55028717
168Distal lower limb muscle weakness (HP:0009053)1.53260592
169Enlarged penis (HP:0000040)1.52363836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.89180286
2NUAK12.79052471
3INSRR2.68680410
4RIPK42.58257866
5LATS12.47352635
6CAMK1D2.33260791
7CAMK1G2.32419780
8TIE12.30781291
9CDK122.05809598
10FGFR21.98686813
11PRPF4B1.98269423
12IRAK41.93785063
13DMPK1.90952509
14TGFBR21.84987947
15STK31.82059316
16MAP3K21.80816206
17EPHB11.78303461
18TEC1.67201646
19IRAK31.66893441
20ERBB31.66143498
21TAOK31.49604253
22PIK3CG1.48079021
23WNK11.47331179
24STK391.46765283
25SGK31.42176525
26TXK1.42061651
27IRAK21.42018241
28MAP3K141.35010812
29JAK11.33994223
30BRD41.32905556
31SGK21.31314330
32STK241.31306383
33ZAP701.30947879
34PLK41.30752330
35GRK71.29271733
36MAP3K31.27717991
37EPHA31.27013281
38ACVR1B1.25379938
39ZAK1.24279820
40TRPM71.24262830
41IKBKE1.23350248
42MAP3K61.22928009
43EIF2AK21.22721472
44FGFR31.17827413
45PRKAA21.16615265
46MARK21.12599432
47KSR21.11337925
48MAP3K11.10643553
49STK101.09923392
50KIT1.09464534
51CDK61.08833437
52PHKG21.08812720
53PHKG11.08812720
54PTK2B1.06869102
55AKT31.06753663
56CHUK1.06628283
57TAOK11.05322254
58MAP3K131.04982304
59SYK1.04437806
60MAPK121.04120648
61FGR1.01854082
62CAMKK21.01239404
63GRK61.01201219
64KSR10.99288060
65ITK0.98804784
66MAPKAPK50.98675377
67TTN0.98290892
68RIPK10.97838851
69CDK90.93458364
70OBSCN0.93114329
71SGK4940.92511075
72SGK2230.92511075
73MKNK20.92127654
74MKNK10.91288726
75MAP2K40.88776117
76JAK30.88291928
77MAP2K30.87058162
78IKBKB0.85938448
79MARK30.85378412
80CAMK40.85308178
81CLK10.82593217
82TYK20.80922737
83PDK10.80918239
84MELK0.79866031
85BTK0.79820388
86HIPK20.79691302
87RET0.77327868
88STK40.77169536
89CSK0.76676575
90PRKCH0.75939743
91NEK90.75134319
92BMPR20.74150639
93LMTK20.71295886
94PKN10.70963565
95GRK10.70519829
96TBK10.70135509
97OXSR10.67975866
98PRKD20.67294335
99MAP3K100.66644148
100MAPK70.63825568
101CSNK1A1L0.63722087
102LYN0.62271822
103HCK0.62162903
104PTK60.61524181
105BLK0.61232724
106CDK30.58642772
107PDPK10.58139010
108PRKCQ0.58030112
109SGK10.57608950
110PIM10.57451614
111STK380.57336826
112WNK40.57290968
113PIK3CA0.56612419
114PINK10.56211945
115IRAK10.55521385
116TNK20.54988240
117GSK3A0.54293188
118BMX0.54035630
119CSF1R0.53714104
120ERN10.52269257
121LCK0.51688443
122MAPKAPK20.51539107
123FES0.51105854
124DAPK20.50481458
125MTOR0.50224063
126MUSK0.49902780
127NLK0.49436129
128DYRK1B0.48647711
129YES10.48004696
130PRKAA10.47522844
131RAF10.46931363
132MAP4K10.46751172
133ABL10.46392033
134MAP3K70.46133703
135STK110.45172066
136JAK20.45018567
137CDC42BPA0.44358162
138PDGFRB0.43896080
139ALK0.43005949
140MAP3K50.42974200
141NEK60.42963196
142FER0.42370532
143ERBB20.41327740

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040641.96898309
2Osteoclast differentiation_Homo sapiens_hsa043801.77927538
3Leishmaniasis_Homo sapiens_hsa051401.68862062
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.67925498
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62103796
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.60756343
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55482321
8Lysine degradation_Homo sapiens_hsa003101.55329526
9Small cell lung cancer_Homo sapiens_hsa052221.51959847
10Toxoplasmosis_Homo sapiens_hsa051451.49404676
11Measles_Homo sapiens_hsa051621.47637347
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46355532
13Staphylococcus aureus infection_Homo sapiens_hsa051501.44400368
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40996727
15Inositol phosphate metabolism_Homo sapiens_hsa005621.40619853
16TNF signaling pathway_Homo sapiens_hsa046681.39838395
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.38978321
18Sphingolipid metabolism_Homo sapiens_hsa006001.34803556
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27743530
20Platelet activation_Homo sapiens_hsa046111.27303656
21Viral myocarditis_Homo sapiens_hsa054161.26051477
22Adherens junction_Homo sapiens_hsa045201.24854801
23Pancreatic cancer_Homo sapiens_hsa052121.24045070
24Herpes simplex infection_Homo sapiens_hsa051681.23444943
25Hematopoietic cell lineage_Homo sapiens_hsa046401.22057700
26* B cell receptor signaling pathway_Homo sapiens_hsa046621.21913442
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20112646
28* Chemokine signaling pathway_Homo sapiens_hsa040621.16934086
29* Jak-STAT signaling pathway_Homo sapiens_hsa046301.15957426
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.15617289
31Allograft rejection_Homo sapiens_hsa053301.12908428
32* Prostate cancer_Homo sapiens_hsa052151.12164315
33VEGF signaling pathway_Homo sapiens_hsa043701.09380334
34Ovarian steroidogenesis_Homo sapiens_hsa049131.08890815
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07129693
36* Chronic myeloid leukemia_Homo sapiens_hsa052201.06618269
37* Hepatitis C_Homo sapiens_hsa051601.04675355
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04498712
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04079597
40Fanconi anemia pathway_Homo sapiens_hsa034601.03808226
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03432763
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02405773
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.01481638
44Long-term potentiation_Homo sapiens_hsa047201.00861449
45* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00482473
46Dilated cardiomyopathy_Homo sapiens_hsa054141.00125154
47Autoimmune thyroid disease_Homo sapiens_hsa053200.99985925
48Asthma_Homo sapiens_hsa053100.99474417
49Influenza A_Homo sapiens_hsa051640.99326914
50Hepatitis B_Homo sapiens_hsa051610.99115133
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.99073403
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97849090
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97399179
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97205563
55Renin secretion_Homo sapiens_hsa049240.97149381
56* GnRH signaling pathway_Homo sapiens_hsa049120.96955741
57Type II diabetes mellitus_Homo sapiens_hsa049300.96126261
58Legionellosis_Homo sapiens_hsa051340.95253222
59* FoxO signaling pathway_Homo sapiens_hsa040680.95234761
60mTOR signaling pathway_Homo sapiens_hsa041500.94485453
61* Insulin signaling pathway_Homo sapiens_hsa049100.94041184
62* Acute myeloid leukemia_Homo sapiens_hsa052210.93658774
63Notch signaling pathway_Homo sapiens_hsa043300.92551524
64ECM-receptor interaction_Homo sapiens_hsa045120.90889553
65Apoptosis_Homo sapiens_hsa042100.90698574
66* Focal adhesion_Homo sapiens_hsa045100.90527950
67Non-homologous end-joining_Homo sapiens_hsa034500.88402703
68* Dorso-ventral axis formation_Homo sapiens_hsa043200.87661021
69* MicroRNAs in cancer_Homo sapiens_hsa052060.87006328
70ABC transporters_Homo sapiens_hsa020100.85622938
71* MAPK signaling pathway_Homo sapiens_hsa040100.85224622
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84521122
73* Renal cell carcinoma_Homo sapiens_hsa052110.82947054
74* Choline metabolism in cancer_Homo sapiens_hsa052310.82437359
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82404546
76* ErbB signaling pathway_Homo sapiens_hsa040120.82130437
77Oxytocin signaling pathway_Homo sapiens_hsa049210.81892831
78* Glioma_Homo sapiens_hsa052140.81538066
79* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81215370
80Ether lipid metabolism_Homo sapiens_hsa005650.80856089
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80410513
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80317341
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79728824
84* T cell receptor signaling pathway_Homo sapiens_hsa046600.79528335
85* Prolactin signaling pathway_Homo sapiens_hsa049170.79028046
86Insulin resistance_Homo sapiens_hsa049310.78932403
87Graft-versus-host disease_Homo sapiens_hsa053320.78476390
88* Pathways in cancer_Homo sapiens_hsa052000.78398318
89Malaria_Homo sapiens_hsa051440.78336828
90* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76414842
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76207984
92Primary immunodeficiency_Homo sapiens_hsa053400.73423840
93HTLV-I infection_Homo sapiens_hsa051660.73350872
94* Estrogen signaling pathway_Homo sapiens_hsa049150.72873624
95Tuberculosis_Homo sapiens_hsa051520.71296054
96AMPK signaling pathway_Homo sapiens_hsa041520.69568858
97Cholinergic synapse_Homo sapiens_hsa047250.69294144
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68546798
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67260479
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66771237
101Long-term depression_Homo sapiens_hsa047300.66672025
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66160503
103* Endometrial cancer_Homo sapiens_hsa052130.65893216
104* Neurotrophin signaling pathway_Homo sapiens_hsa047220.65820780
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65087930
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.64824629
107HIF-1 signaling pathway_Homo sapiens_hsa040660.64284111
108Glucagon signaling pathway_Homo sapiens_hsa049220.63868417
109* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63646574
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63590042
111Phagosome_Homo sapiens_hsa041450.63573953
112* Ras signaling pathway_Homo sapiens_hsa040140.62585812
113* Proteoglycans in cancer_Homo sapiens_hsa052050.62463299
114Amoebiasis_Homo sapiens_hsa051460.62227139
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61228801
116cAMP signaling pathway_Homo sapiens_hsa040240.60885920
117Axon guidance_Homo sapiens_hsa043600.60709739
118* Non-small cell lung cancer_Homo sapiens_hsa052230.59538408
119* Phospholipase D signaling pathway_Homo sapiens_hsa040720.59280598
120Circadian rhythm_Homo sapiens_hsa047100.58976331
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58394089
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58177083
123Colorectal cancer_Homo sapiens_hsa052100.57210962
124Pertussis_Homo sapiens_hsa051330.56805192
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56280312
126Viral carcinogenesis_Homo sapiens_hsa052030.55765188
127Rap1 signaling pathway_Homo sapiens_hsa040150.55696384
128Gastric acid secretion_Homo sapiens_hsa049710.55583467
129Pancreatic secretion_Homo sapiens_hsa049720.55446936
130African trypanosomiasis_Homo sapiens_hsa051430.52720560
131Endocytosis_Homo sapiens_hsa041440.52561947

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