SOST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of biomineral tissue development (GO:0070168)9.61458119
2cell aggregation (GO:0098743)9.59141977
3cartilage condensation (GO:0001502)9.59141977
4hypotonic response (GO:0006971)7.92223116
5positive regulation of epidermal cell differentiation (GO:0045606)7.89774813
6keratan sulfate biosynthetic process (GO:0018146)7.43033059
7thrombin receptor signaling pathway (GO:0070493)7.36167632
8extracellular matrix assembly (GO:0085029)6.94317995
9cyclooxygenase pathway (GO:0019371)6.78813055
10positive regulation of receptor internalization (GO:0002092)6.63033378
11keratan sulfate metabolic process (GO:0042339)6.48750286
12decidualization (GO:0046697)6.48651426
13regulation of alkaline phosphatase activity (GO:0010692)6.05630035
14regulation of bone remodeling (GO:0046850)6.02656183
15tonic smooth muscle contraction (GO:0014820)6.00548969
16regulation of bone mineralization (GO:0030500)5.75458850
17cGMP-mediated signaling (GO:0019934)5.67220342
18galactose catabolic process (GO:0019388)5.57697163
19heme transport (GO:0015886)5.55209219
20chondrocyte development (GO:0002063)5.43481328
21regulation of biomineral tissue development (GO:0070167)5.42594144
22* ossification (GO:0001503)5.36470491
23relaxation of smooth muscle (GO:0044557)5.19019794
24positive regulation of epidermis development (GO:0045684)5.16655925
25phosphate ion transmembrane transport (GO:0035435)4.99977473
26cellular response to vitamin D (GO:0071305)4.99648179
27embryonic process involved in female pregnancy (GO:0060136)4.97187737
28sulfur compound catabolic process (GO:0044273)4.96835501
29cellular response to vitamin (GO:0071295)4.91882542
30bone development (GO:0060348)4.79462734
31prostaglandin biosynthetic process (GO:0001516)4.71227506
32prostanoid biosynthetic process (GO:0046457)4.71227506
33embryonic viscerocranium morphogenesis (GO:0048703)4.69125205
34sequestering of extracellular ligand from receptor (GO:0035581)4.55785554
35regulation of receptor internalization (GO:0002090)4.55536966
36prostanoid metabolic process (GO:0006692)4.48961506
37prostaglandin metabolic process (GO:0006693)4.48961506
38bone resorption (GO:0045453)4.42047071
39skeletal system development (GO:0001501)4.37423451
40protein heterotrimerization (GO:0070208)4.32077522
41negative regulation of smooth muscle contraction (GO:0045986)4.25749622
42regulation of G0 to G1 transition (GO:0070316)4.25129656
43lymphangiogenesis (GO:0001946)4.25103128
44phosphate ion transport (GO:0006817)4.18272854
45positive regulation of cardiac muscle cell differentiation (GO:2000727)4.16326671
46positive regulation of collagen biosynthetic process (GO:0032967)4.13679834
47regulation of sarcomere organization (GO:0060297)4.09069532
48response to folic acid (GO:0051593)4.08300686
49collagen fibril organization (GO:0030199)4.05787172
50regulation of tissue remodeling (GO:0034103)4.05518928
51glycosaminoglycan catabolic process (GO:0006027)4.01167486
52ovulation (GO:0030728)3.99708769
53cartilage morphogenesis (GO:0060536)3.99214910
54platelet dense granule organization (GO:0060155)3.93833257
55cartilage development (GO:0051216)3.93761570
56hematopoietic stem cell differentiation (GO:0060218)3.93281849
57positive regulation of collagen metabolic process (GO:0010714)3.92070481
58import into cell (GO:0098657)3.88796726
59cellular response to osmotic stress (GO:0071470)3.87632066
60substrate-dependent cell migration (GO:0006929)3.82185289
61regulation of acrosome reaction (GO:0060046)3.81093197
62cardiac muscle cell development (GO:0055013)3.77756902
63* negative regulation of ossification (GO:0030279)3.76313495
64regulation of epidermal cell differentiation (GO:0045604)3.72037391
65regulation of skeletal muscle contraction (GO:0014819)3.71415834
66positive regulation of protein homodimerization activity (GO:0090073)3.69049924
67tissue remodeling (GO:0048771)3.67845049
68fusion of sperm to egg plasma membrane (GO:0007342)3.64200488
69aminoglycan catabolic process (GO:0006026)3.59045251
70collagen metabolic process (GO:0032963)3.59043686
71negative regulation of glycogen biosynthetic process (GO:0045719)3.58706051
72glomerular visceral epithelial cell development (GO:0072015)3.58449381
73iron coordination entity transport (GO:1901678)3.57803347
74cardiac cell development (GO:0055006)3.56670655
75heart field specification (GO:0003128)3.56079501
76secondary heart field specification (GO:0003139)3.56079501
77cellular response to ATP (GO:0071318)3.55781210
78collagen catabolic process (GO:0030574)3.54858892
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.54296053
80renal filtration (GO:0097205)3.53675866
81iron ion import (GO:0097286)3.52058082
82multicellular organismal macromolecule metabolic process (GO:0044259)3.51955951
83glomerular filtration (GO:0003094)3.49894895
84anion homeostasis (GO:0055081)3.49237253
85urate metabolic process (GO:0046415)3.48449090
86fibroblast migration (GO:0010761)3.45733177
87epithelial cell differentiation involved in kidney development (GO:0035850)3.44052674
88glomerular basement membrane development (GO:0032836)3.39869473
89mitochondrial genome maintenance (GO:0000002)3.39406353
90complement activation, alternative pathway (GO:0006957)3.39361982
91vasculature development (GO:0001944)3.38138092
92response to gravity (GO:0009629)3.38127519
93negative regulation of JNK cascade (GO:0046329)3.37292384
94regulation of collagen biosynthetic process (GO:0032965)3.36230838
95germinal center formation (GO:0002467)3.35889137
96positive regulation of receptor-mediated endocytosis (GO:0048260)3.35427990
97multicellular organismal metabolic process (GO:0044236)3.35010056
98multicellular organismal catabolic process (GO:0044243)3.32815831
99plasma membrane repair (GO:0001778)3.31439671
100mesodermal cell differentiation (GO:0048333)3.31179994
101positive regulation of Rho protein signal transduction (GO:0035025)3.29569259
102apoptotic cell clearance (GO:0043277)3.29545901
103vascular endothelial growth factor signaling pathway (GO:0038084)3.28817309
104response to vitamin D (GO:0033280)3.27923594
105cellular response to fluid shear stress (GO:0071498)3.27097862
106cell morphogenesis involved in neuron differentiation (GO:0048667)3.25554797
107osteoblast differentiation (GO:0001649)3.23564527
108positive regulation of muscle hypertrophy (GO:0014742)3.23049116
109positive regulation of cardiac muscle hypertrophy (GO:0010613)3.23049116
110drug transmembrane transport (GO:0006855)3.23018381
111regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.20399859
112regulation of germinal center formation (GO:0002634)3.19524463
113positive regulation of blood vessel endothelial cell migration (GO:0043536)3.19078556
114relaxation of muscle (GO:0090075)3.18857918
115retina vasculature morphogenesis in camera-type eye (GO:0061299)3.15640287
116plasma membrane fusion (GO:0045026)3.14599375
117biomineral tissue development (GO:0031214)3.13949834
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13739623
119mitochondrion distribution (GO:0048311)3.12456878
120adhesion of symbiont to host cell (GO:0044650)3.11599243
121virion attachment to host cell (GO:0019062)3.11599243
122glomerular epithelial cell development (GO:0072310)3.10754785
123negative regulation of muscle contraction (GO:0045932)3.09103533
124smooth muscle contraction (GO:0006939)3.06458673
125negative regulation of protein autophosphorylation (GO:0031953)3.04567985
126negative regulation of stress-activated MAPK cascade (GO:0032873)3.04527323
127negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.04527323
128low-density lipoprotein particle clearance (GO:0034383)3.02769570
129cell adhesion mediated by integrin (GO:0033627)3.01700308
130chondrocyte proliferation (GO:0035988)3.01355904
131regulation of smooth muscle contraction (GO:0006940)3.00515473
132positive regulation of phosphatase activity (GO:0010922)3.00303524
133axon extension involved in axon guidance (GO:0048846)3.00135169
134neuron projection extension involved in neuron projection guidance (GO:1902284)3.00135169
135regulation of collagen metabolic process (GO:0010712)3.00040929
136negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.99885658
137transcytosis (GO:0045056)2.96768535
138regulation of transforming growth factor beta2 production (GO:0032909)2.94231855
139skin morphogenesis (GO:0043589)2.92938448
140bone mineralization (GO:0030282)2.92323325
141regulation of glomerular filtration (GO:0003093)2.92022814
142phagocytosis, recognition (GO:0006910)2.91890870
143cellular response to antibiotic (GO:0071236)2.91305882
144galactose metabolic process (GO:0006012)2.91176710
145stress fiber assembly (GO:0043149)2.88886681
146negative regulation of hormone biosynthetic process (GO:0032353)2.87514393
147positive regulation of cell-substrate adhesion (GO:0010811)2.87293074
148glycosaminoglycan biosynthetic process (GO:0006024)2.87223868
149mesenchymal-epithelial cell signaling (GO:0060638)2.85027745
150cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84078095
151positive regulation of prostaglandin secretion (GO:0032308)2.83958876
152aminoglycan biosynthetic process (GO:0006023)2.83324572
153branching involved in salivary gland morphogenesis (GO:0060445)2.82769415
154protein localization to cell surface (GO:0034394)2.77173124
155alpha-linolenic acid metabolic process (GO:0036109)2.75766126
156positive regulation of heat generation (GO:0031652)2.75461949
157regulation of Golgi to plasma membrane protein transport (GO:0042996)2.74817000
158extracellular matrix disassembly (GO:0022617)2.74007268
159platelet aggregation (GO:0070527)2.73311589
160response to phenylpropanoid (GO:0080184)2.72977423
161cellular response to nutrient (GO:0031670)2.72229281
162regulation of muscle contraction (GO:0006937)2.68381636
163cardiac myofibril assembly (GO:0055003)2.68125488
164positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.61567835
165smooth muscle tissue development (GO:0048745)2.58593529
166cell-substrate junction assembly (GO:0007044)2.58165421
167chronic inflammatory response (GO:0002544)2.57927441
168replacement ossification (GO:0036075)2.53017575
169endochondral ossification (GO:0001958)2.53017575
170endothelial cell morphogenesis (GO:0001886)2.51739866
171extracellular matrix organization (GO:0030198)2.51429297
172regulation of fever generation (GO:0031620)2.50361512
173extracellular structure organization (GO:0043062)2.50331828
174substrate adhesion-dependent cell spreading (GO:0034446)2.49186164
175cardiac muscle cell proliferation (GO:0060038)2.49010088
176positive regulation of wound healing (GO:0090303)2.48849879
177regulation of muscle system process (GO:0090257)2.48783292
178positive regulation of cellular response to insulin stimulus (GO:1900078)2.48758063
179brown fat cell differentiation (GO:0050873)2.47841605
180cellular sodium ion homeostasis (GO:0006883)2.47578942
181regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45960010
182cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44244059
183cell migration involved in sprouting angiogenesis (GO:0002042)2.44179048
184establishment of nucleus localization (GO:0040023)2.44160991
185keratan sulfate catabolic process (GO:0042340)17.2830790
186trivalent inorganic anion homeostasis (GO:0072506)13.1103466
187phosphate ion homeostasis (GO:0055062)13.1103466
188negative regulation of bone mineralization (GO:0030502)10.5514759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.36391370
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.52590458
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24900960
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.18032912
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.05516913
6CLOCK_20551151_ChIP-Seq_293T_Human2.82747194
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.62012703
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.58561094
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57883987
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.46612590
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.45928421
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45525259
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.43386496
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.39799195
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35960787
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35228252
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.22566366
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21673558
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.20398434
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.14186676
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12896678
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12896678
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12896678
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06717252
25CEBPB_26923725_Chip-Seq_MESODERM_Mouse2.06370299
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05947145
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02457453
28EZH2_22144423_ChIP-Seq_EOC_Human1.99040891
29P300_19829295_ChIP-Seq_ESCs_Human1.98252214
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97401268
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94908042
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87121604
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78642950
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76887133
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76209700
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70236651
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69033937
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68778638
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67812781
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67812781
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67056025
42CJUN_26792858_Chip-Seq_BT549_Human1.66498627
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65357846
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.65182401
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64715719
46CBP_20019798_ChIP-Seq_JUKART_Human1.64715719
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64056692
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.63698075
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.63491958
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60125645
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58091663
52HTT_18923047_ChIP-ChIP_STHdh_Human1.57620733
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56500511
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55298136
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.54561397
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.54561397
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54521583
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.54239163
59SMAD4_21799915_ChIP-Seq_A2780_Human1.52264092
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51390360
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50611552
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.49840629
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48352387
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47458871
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.42321545
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41790614
67TP53_18474530_ChIP-ChIP_U2OS_Human1.41377164
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39735477
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39575343
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39548440
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37245480
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36586872
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34702961
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34201237
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.33707576
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33548652
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.31617887
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.30187739
79* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29560239
80BRD4_25478319_ChIP-Seq_HGPS_Human1.28596177
81RXR_22108803_ChIP-Seq_LS180_Human1.26430724
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25064751
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25027008
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24012216
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23813939
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.22702934
87* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22082718
88KDM2B_26808549_Chip-Seq_K562_Human1.21106168
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20336950
90* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20009616
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19616198
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.18311448
93ZNF263_19887448_ChIP-Seq_K562_Human1.18238293
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18197238
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17922912
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.16815394
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16631879
98TP53_16413492_ChIP-PET_HCT116_Human1.15729273
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15564412
100SOX2_20726797_ChIP-Seq_SW620_Human1.15135274
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14735568
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14166063
103* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13214860
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13055995
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13055995
106STAT3_23295773_ChIP-Seq_U87_Human1.12887254
107* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12442130
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11769190
109CDX2_22108803_ChIP-Seq_LS180_Human1.11366781
110* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11353406
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10758195
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09845618
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09800517
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.09517462
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08717233
116DROSHA_22980978_ChIP-Seq_HELA_Human1.08117759
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.08086507
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07500362
119* RXR_22158963_ChIP-Seq_LIVER_Mouse1.07179023
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06848281
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06665955
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06296830
123AHR_22903824_ChIP-Seq_MCF-7_Human1.06250759
124P53_22387025_ChIP-Seq_ESCs_Mouse1.06186390
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.05710504
126ER_23166858_ChIP-Seq_MCF-7_Human1.05424503
127ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04736319
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04379163
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03800352
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.03788203
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03474724
132* TP63_23658742_ChIP-Seq_EP156T_Human1.03416577
133* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03340634
134FLI1_27457419_Chip-Seq_LIVER_Mouse1.03078799
135GBX2_23144817_ChIP-Seq_PC3_Human1.02792039
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01840754
137* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01104381
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01061484
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01003797
140HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00909045
141MYC_19829295_ChIP-Seq_ESCs_Human1.00077301
142RACK7_27058665_Chip-Seq_MCF-7_Human0.98796052
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.97280013
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97020640
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.96930272
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96620350
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96451681
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96337706
149FLI1_21867929_ChIP-Seq_TH2_Mouse0.96111712
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95742603
151GATA1_22025678_ChIP-Seq_K562_Human0.95662562
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.95335249
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.94444160
154* RNF2_27304074_Chip-Seq_ESCs_Mouse0.94017934
155TAF15_26573619_Chip-Seq_HEK293_Human0.93801219
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93696508
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93665500
158TP53_22127205_ChIP-Seq_IMR90_Human0.93478310
159* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92948650
160* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92948650
161DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91955416
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91863859
163* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91284469
164ATF3_27146783_Chip-Seq_COLON_Human0.90678337
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.90543768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.44019240
2MP0004185_abnormal_adipocyte_glucose4.91488570
3MP0008438_abnormal_cutaneous_collagen4.52311124
4MP0010386_abnormal_urinary_bladder3.88999226
5MP0003195_calcinosis3.69912484
6MP0004147_increased_porphyrin_level3.53596512
7MP0005666_abnormal_adipose_tissue3.29263922
8MP0005275_abnormal_skin_tensile3.21207813
9MP0002837_dystrophic_cardiac_calcinosis3.20785523
10MP0000751_myopathy3.00828955
11MP0002089_abnormal_postnatal_growth/wei2.96053028
12MP0008004_abnormal_stomach_pH2.81523515
13* MP0002109_abnormal_limb_morphology2.80925226
14* MP0001542_abnormal_bone_strength2.70476967
15MP0000569_abnormal_digit_pigmentation2.66814459
16MP0004036_abnormal_muscle_relaxation2.63960408
17MP0005084_abnormal_gallbladder_morpholo2.61966147
18MP0004272_abnormal_basement_membrane2.58877110
19MP0010368_abnormal_lymphatic_system2.54836496
20MP0000462_abnormal_digestive_system2.54312320
21MP0003718_maternal_effect2.46736644
22MP0005375_adipose_tissue_phenotype2.45318800
23MP0001958_emphysema2.38643273
24MP0000013_abnormal_adipose_tissue2.38309238
25MP0003045_fibrosis2.33054250
26MP0004019_abnormal_vitamin_homeostasis2.32795591
27MP0000750_abnormal_muscle_regeneration2.30994276
28MP0003705_abnormal_hypodermis_morpholog2.24906958
29MP0005503_abnormal_tendon_morphology2.19582635
30MP0005330_cardiomyopathy2.16283806
31MP0004084_abnormal_cardiac_muscle2.08275066
32MP0005623_abnormal_meninges_morphology2.07688828
33MP0003566_abnormal_cell_adhesion2.06177630
34MP0010352_gastrointestinal_tract_polyps2.02692968
35MP0003935_abnormal_craniofacial_develop1.99258288
36MP0005620_abnormal_muscle_contractility1.98410846
37MP0003279_aneurysm1.97739199
38MP0003303_peritoneal_inflammation1.82358133
39MP0000432_abnormal_head_morphology1.80373154
40MP0000230_abnormal_systemic_arterial1.79840782
41MP0005365_abnormal_bile_salt1.66428915
42MP0002933_joint_inflammation1.64763372
43MP0001756_abnormal_urination1.63140471
44MP0002116_abnormal_craniofacial_bone1.62414442
45MP0002295_abnormal_pulmonary_circulatio1.61857044
46MP0001664_abnormal_digestion1.59947547
47MP0000538_abnormal_urinary_bladder1.55208581
48MP0002896_abnormal_bone_mineralization1.54014384
49MP0003183_abnormal_peptide_metabolism1.47976881
50MP0006138_congestive_heart_failure1.46438471
51MP0005023_abnormal_wound_healing1.43321851
52* MP0002998_abnormal_bone_remodeling1.43291004
53MP0000003_abnormal_adipose_tissue1.43057588
54MP0002233_abnormal_nose_morphology1.39938830
55MP0004484_altered_response_of1.37689779
56MP0001666_abnormal_nutrient_absorption1.36836239
57MP0001879_abnormal_lymphatic_vessel1.35865785
58MP0004087_abnormal_muscle_fiber1.34190958
59MP0005164_abnormal_response_to1.31598498
60MP0004130_abnormal_muscle_cell1.28022688
61MP0004215_abnormal_myocardial_fiber1.24307963
62MP0004885_abnormal_endolymph1.23967452
63MP0006054_spinal_hemorrhage1.22674180
64MP0001533_abnormal_skeleton_physiology1.21919248
65MP0000537_abnormal_urethra_morphology1.20433036
66MP0002114_abnormal_axial_skeleton1.18051914
67MP0002932_abnormal_joint_morphology1.17890295
68MP0002972_abnormal_cardiac_muscle1.14621571
69MP0005076_abnormal_cell_differentiation1.14521573
70MP0002108_abnormal_muscle_morphology1.14326287
71MP0002168_other_aberrant_phenotype1.10885661
72MP0001727_abnormal_embryo_implantation1.10723095
73MP0003091_abnormal_cell_migration1.09935250
74MP0009780_abnormal_chondrocyte_physiolo1.07150960
75MP0003646_muscle_fatigue1.06382088
76MP0001765_abnormal_ion_homeostasis1.03365087
77MP0002332_abnormal_exercise_endurance1.02962835
78* MP0002115_abnormal_skeleton_extremities1.02399994
79MP0001544_abnormal_cardiovascular_syste1.01846408
80MP0005385_cardiovascular_system_phenoty1.01846408
81MP0005381_digestive/alimentary_phenotyp1.01397472
82MP0000767_abnormal_smooth_muscle0.99333769
83MP0008775_abnormal_heart_ventricle0.98677144
84MP0003942_abnormal_urinary_system0.97495199
85MP0000749_muscle_degeneration0.96924691
86MP0000163_abnormal_cartilage_morphology0.94294704
87MP0001270_distended_abdomen0.91260657
88MP0010630_abnormal_cardiac_muscle0.90939770
89MP0009384_cardiac_valve_regurgitation0.88358432
90MP0009115_abnormal_fat_cell0.87266850
91MP0005390_skeleton_phenotype0.86695803
92MP0004145_abnormal_muscle_electrophysio0.86427847
93MP0004510_myositis0.86211987
94MP0005257_abnormal_intraocular_pressure0.86020687
95MP0005595_abnormal_vascular_smooth0.85257125
96MP0003385_abnormal_body_wall0.84793391
97MP0009250_abnormal_appendicular_skeleto0.82242630
98MP0002111_abnormal_tail_morphology0.81939677
99MP0005166_decreased_susceptibility_to0.81718868
100MP0004085_abnormal_heartbeat0.80982578
101MP0003828_pulmonary_edema0.80882682
102MP0003950_abnormal_plasma_membrane0.78897086
103MP0003300_gastrointestinal_ulcer0.78180099
104MP0002254_reproductive_system_inflammat0.76525165
105* MP0003795_abnormal_bone_structure0.76377503
106MP0004134_abnormal_chest_morphology0.76140779
107MP0001177_atelectasis0.75833189
108MP0005085_abnormal_gallbladder_physiolo0.75683365
109MP0005187_abnormal_penis_morphology0.75409874
110MP0001614_abnormal_blood_vessel0.75377063
111MP0003137_abnormal_impulse_conducting0.74934053
112MP0010030_abnormal_orbit_morphology0.74385429
113MP0002396_abnormal_hematopoietic_system0.74163391
114MP0002419_abnormal_innate_immunity0.74079749
115MP0002163_abnormal_gland_morphology0.73978370
116MP0005369_muscle_phenotype0.72439948
117MP0000534_abnormal_ureter_morphology0.72402295
118MP0002128_abnormal_blood_circulation0.72175708
119MP0005508_abnormal_skeleton_morphology0.71002015
120MP0002282_abnormal_trachea_morphology0.70905982
121MP0002060_abnormal_skin_morphology0.69832373
122MP0002106_abnormal_muscle_physiology0.69691629
123* MP0002113_abnormal_skeleton_development0.68821629
124MP0010234_abnormal_vibrissa_follicle0.68473549
125MP0005174_abnormal_tail_pigmentation0.68071281
126MP0001299_abnormal_eye_distance/0.67543688
127MP0002177_abnormal_outer_ear0.66416018
128MP0003283_abnormal_digestive_organ0.66164546
129MP0000733_abnormal_muscle_development0.66040660
130MP0002736_abnormal_nociception_after0.65254723
131MP0000604_amyloidosis0.63839760
132MP0005395_other_phenotype0.62750166
133MP0003868_abnormal_feces_composition0.62196761
134MP0004883_abnormal_blood_vessel0.59811648
135MP0005636_abnormal_mineral_homeostasis0.59031040
136MP0000026_abnormal_inner_ear0.58943377
137MP0000358_abnormal_cell_content/0.48200788
138MP0002249_abnormal_larynx_morphology0.46893025
139MP0002877_abnormal_melanocyte_morpholog0.46268035
140MP0003959_abnormal_lean_body0.44653261
141MP0001731_abnormal_postnatal_growth0.44466894
142MP0000428_abnormal_craniofacial_morphol0.44357965
143MP0001963_abnormal_hearing_physiology0.43295794
144MP0002876_abnormal_thyroid_physiology0.42852157
145MP0003755_abnormal_palate_morphology0.42757775
146MP0000681_abnormal_thyroid_gland0.42704961
147MP0004924_abnormal_behavior0.41759530
148MP0005386_behavior/neurological_phenoty0.41759530
149MP0003937_abnormal_limbs/digits/tail_de0.40966016
150MP0001919_abnormal_reproductive_system0.40682531
151MP0000465_gastrointestinal_hemorrhage0.40348176
152MP0005377_hearing/vestibular/ear_phenot0.39783691
153MP0003878_abnormal_ear_physiology0.39783691
154MP0001286_abnormal_eye_development0.37330116
155MP0003941_abnormal_skin_development0.35810276
156MP0005621_abnormal_cell_physiology0.34065999
157MP0001502_abnormal_circadian_rhythm0.32194352
158MP0000685_abnormal_immune_system0.31889092
159MP0000579_abnormal_nail_morphology0.31641075

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)9.31863202
2* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)8.10433243
3Enlarged epiphyses (HP:0010580)7.11704802
4Rickets (HP:0002748)7.03007136
5Mild short stature (HP:0003502)7.02203610
6Irregular vertebral endplates (HP:0003301)6.97953622
7Osteomalacia (HP:0002749)6.76345384
8Spinal cord compression (HP:0002176)6.59804608
9* Abnormality of the vertebral endplates (HP:0005106)5.76340529
10Hypophosphatemia (HP:0002148)5.46279482
11Genu varum (HP:0002970)5.32039491
12Aortic regurgitation (HP:0001659)5.08520432
13Spondylolisthesis (HP:0003302)4.75502232
14Protrusio acetabuli (HP:0003179)4.54995960
15* Craniofacial hyperostosis (HP:0004493)4.51615974
16Ulnar bowing (HP:0003031)4.29876594
17* Abnormality of calcium-phosphate metabolism (HP:0100530)4.29521952
18Aneurysm (HP:0002617)4.29339455
19* Facial diplegia (HP:0001349)4.26127411
20Premature rupture of membranes (HP:0001788)4.15271433
21Ankle contracture (HP:0006466)4.13804596
22Metaphyseal irregularity (HP:0003025)4.11843124
23* Cranial hyperostosis (HP:0004437)4.04847407
24Coxa vara (HP:0002812)3.97594880
25Small epiphyses (HP:0010585)3.88714187
26Type 1 muscle fiber predominance (HP:0003803)3.81860967
27Abnormality of Sharpey fibers (HP:0100685)3.68875095
28Short middle phalanx of finger (HP:0005819)3.64408498
29Metaphyseal cupping (HP:0003021)3.64100529
30Bicuspid aortic valve (HP:0001647)3.55755680
31Cerebral aneurysm (HP:0004944)3.52150538
32Osteolytic defects of the hand bones (HP:0009699)3.40974853
33Osteolytic defects of the phalanges of the hand (HP:0009771)3.40974853
34Neoplasm of the heart (HP:0100544)3.31128850
35Broad metatarsal (HP:0001783)3.26235074
36Radial bowing (HP:0002986)3.25500304
37Abnormality of the epiphysis of the femoral head (HP:0010574)3.24409735
38Muscle fiber splitting (HP:0003555)3.23795371
39Arthropathy (HP:0003040)3.23640202
40Abnormality of the frontal sinuses (HP:0002687)3.21980491
41Wormian bones (HP:0002645)3.16341136
42Scapular winging (HP:0003691)3.15176012
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.12868255
44Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.02867385
45Abnormality of femoral epiphyses (HP:0006499)3.02867385
46Abnormality of the femoral head (HP:0003368)2.96629358
47Wrist flexion contracture (HP:0001239)2.94472867
48Abnormality of the calcaneus (HP:0008364)2.92786638
49Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.82124921
50Bowed forearm bones (HP:0003956)2.81883618
51Bowing of the arm (HP:0006488)2.81883618
52Increased connective tissue (HP:0009025)2.80996627
53Shallow orbits (HP:0000586)2.79822439
54Hyporeflexia of lower limbs (HP:0002600)2.74247778
55Abnormality of the 4th metacarpal (HP:0010012)2.73567287
56Round ear (HP:0100830)2.71211045
57Tibial bowing (HP:0002982)2.69086647
58Spinal canal stenosis (HP:0003416)2.68343635
59Malnutrition (HP:0004395)2.67592417
60Mitral valve prolapse (HP:0001634)2.67177345
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66974296
62Short 4th metacarpal (HP:0010044)2.66974296
63Facial shape deformation (HP:0011334)2.66732375
64Potter facies (HP:0002009)2.66732375
65Knee flexion contracture (HP:0006380)2.66631963
66Abnormality of the acetabulum (HP:0003170)2.62601439
67Persistence of primary teeth (HP:0006335)2.61614525
68Gastrointestinal dysmotility (HP:0002579)2.60307653
69Short hallux (HP:0010109)2.58278655
70Complement deficiency (HP:0004431)2.57045177
71* Increased density of long bones (HP:0006392)2.55913245
72Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.55704258
73Dilatation of the ascending aorta (HP:0005111)2.54370170
74Soft skin (HP:0000977)2.50374632
75Abnormality of the middle phalanges of the hand (HP:0009833)2.49693446
76Growth hormone excess (HP:0000845)2.48098598
77Hip contracture (HP:0003273)2.47895102
78Carpal bone hypoplasia (HP:0001498)2.43014177
79Flared iliac wings (HP:0002869)2.42672051
80Bladder diverticulum (HP:0000015)2.41430487
81Camptodactyly of toe (HP:0001836)2.40118207
82Arterial tortuosity (HP:0005116)2.40011124
83Absent frontal sinuses (HP:0002688)2.38857318
84Calcaneovalgus deformity (HP:0001848)2.36506737
85Stroke (HP:0001297)2.34900187
86Aplasia/Hypoplasia of the hallux (HP:0008362)2.32843481
87Peritonitis (HP:0002586)2.30034147
88Right ventricular cardiomyopathy (HP:0011663)2.29239159
89Ulnar deviation of the wrist (HP:0003049)2.29150553
90Bone pain (HP:0002653)2.27999188
91Elbow flexion contracture (HP:0002987)2.23207970
92Testicular atrophy (HP:0000029)2.21702868
93Femoral bowing (HP:0002980)2.20925228
94Abnormality of abdominal situs (HP:0011620)2.20638588
95Abdominal situs inversus (HP:0003363)2.20638588
96Distal arthrogryposis (HP:0005684)2.20428293
97Deformed tarsal bones (HP:0008119)2.19973693
98Waddling gait (HP:0002515)2.18774563
99Atrophic scars (HP:0001075)2.18640509
100Abnormal cartilage morphology (HP:0002763)2.16641030
101Tarsal synostosis (HP:0008368)2.14320276
102Vascular tortuosity (HP:0004948)2.14295155
103Ventricular tachycardia (HP:0004756)2.11775801
104Long toe (HP:0010511)2.10052828
105Broad phalanges of the hand (HP:0009768)2.08982357
106Abnormal urine phosphate concentration (HP:0012599)2.06799633
107Hypercalcemia (HP:0003072)2.04867106
108Mixed hearing impairment (HP:0000410)2.01948101
109Stridor (HP:0010307)2.01671831
110Increased variability in muscle fiber diameter (HP:0003557)2.00041089
111Metaphyseal dysplasia (HP:0100255)11.7159242
112Aortic aneurysm (HP:0004942)10.9709130
113* Broad ribs (HP:0000885)1.99823197
114Atrioventricular block (HP:0001678)1.99553377
115Broad phalanx (HP:0006009)1.98113987
116Fragile skin (HP:0001030)1.97711493
117Cervical subluxation (HP:0003308)1.96872721
118Broad finger (HP:0001500)1.95982689
119Lipoatrophy (HP:0100578)1.95776739
120Cardiovascular calcification (HP:0011915)1.94926017
121Limited hip movement (HP:0008800)1.92397579
122Synostosis involving bones of the lower limbs (HP:0009138)1.91175553
123Synostosis involving bones of the feet (HP:0009140)1.91175553
124Hypophosphatemic rickets (HP:0004912)1.90876257
125Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89916836
126Abnormality of complement system (HP:0005339)1.88771870
127Mesomelia (HP:0003027)1.88063451
128Broad long bones (HP:0005622)1.88009234
129Myotonia (HP:0002486)1.87675160
130Increased mean platelet volume (HP:0011877)1.86248234
131Lymphangioma (HP:0100764)1.85309336
132Vascular calcification (HP:0004934)1.84311270
133Blue sclerae (HP:0000592)1.84282719
134Flexion contracture of toe (HP:0005830)1.81513447
135Joint contractures involving the joints of the feet (HP:0100492)1.81513447
136Abnormality of the calf musculature (HP:0001430)1.79836810
137Wide anterior fontanel (HP:0000260)1.79583148
138Spinal rigidity (HP:0003306)1.79561278
139Broad distal phalanx of finger (HP:0009836)1.78179599
140Infantile muscular hypotonia (HP:0008947)1.76938392
141Abnormality of the 2nd finger (HP:0004100)1.76480586
142Hyperextensible skin (HP:0000974)1.74523065
143Spastic diplegia (HP:0001264)1.74188912
144Beaking of vertebral bodies (HP:0004568)1.73236360
145Seborrheic dermatitis (HP:0001051)1.73140389
146Chondrocalcinosis (HP:0000934)1.72155830
147Bowel diverticulosis (HP:0005222)1.72067593
148Platyspondyly (HP:0000926)1.71377989
149Abnormality of dentin (HP:0010299)1.70270703
150Osteoarthritis (HP:0002758)1.70196252
151Prominent supraorbital ridges (HP:0000336)1.70044497
152Cupped ribs (HP:0000887)1.69990195
153Delayed closure of the anterior fontanelle (HP:0001476)1.68928253
154Abnormality of the intervertebral disk (HP:0005108)1.68040199
155Syringomyelia (HP:0003396)1.67748322
156Spinal cord lesions (HP:0100561)1.67748322
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66965632
158* Elevated alkaline phosphatase (HP:0003155)1.66800361
159Delayed epiphyseal ossification (HP:0002663)1.64272001
160Short distal phalanx of finger (HP:0009882)1.64131565
161Abnormality of the fibula (HP:0002991)1.63387875
162Renal tubular dysfunction (HP:0000124)1.58201349
163Abnormality of primary teeth (HP:0006481)1.49486054
164* Abnormality of alkaline phosphatase activity (HP:0004379)1.45762360
165Limited elbow extension (HP:0001377)1.45283352
166Hypoplasia of the odontoid process (HP:0003311)1.38842874
167* Abnormal enzyme/coenzyme activity (HP:0012379)1.38543075
168Split foot (HP:0001839)1.33034698
169Short middle phalanx of the 5th finger (HP:0004220)1.32211554
170Narrow palate (HP:0000189)1.29320405
171Absent hand (HP:0004050)1.25799047
172Coronal craniosynostosis (HP:0004440)1.25523080
173Ovoid vertebral bodies (HP:0003300)1.22096537
174Flattened epiphyses (HP:0003071)1.20135432
175Abnormality of the wing of the ilium (HP:0011867)1.17120005
176Delayed eruption of teeth (HP:0000684)1.15147064
177Adactyly (HP:0009776)1.14124963
178Ridged nail (HP:0001807)1.13861018
179Short femoral neck (HP:0100864)1.13626273
180Abnormality of the phalanges of the 2nd finger (HP:0009541)1.11749704
181Xerostomia (HP:0000217)1.11221629
182Delayed cranial suture closure (HP:0000270)1.07881683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.69866795
2DMPK4.81777287
3NTRK23.82687254
4MST1R3.80743119
5MAPK73.61587257
6PIK3CG3.48341754
7TNIK3.43397094
8PNCK3.40381684
9NLK3.40164236
10PAK23.05759761
11DDR22.50565917
12CCNB12.44211857
13MET2.42670213
14TRIB32.23676903
15MST42.21216498
16LATS12.13886108
17MYLK10.4928683
18MAP3K91.83283566
19CDK81.69429030
20TIE11.65994019
21NUAK11.58908879
22SGK21.49682157
23STK241.47227945
24LATS21.44998597
25LMTK21.42526164
26ARAF1.40885788
27CDC42BPA1.39779452
28PDGFRA1.39076696
29AKT31.34639537
30EIF2AK31.33822871
31RIPK11.25650981
32RAF11.22049384
33ROCK11.16944509
34CASK1.15128979
35PKN21.15094880
36ILK1.13228725
37CDK31.11686083
38EPHB21.09194418
39EEF2K1.08851791
40MAP3K131.07419410
41DAPK31.04518542
42TESK11.04155853
43SIK11.03599280
44TAOK31.02880324
45CAMK2G1.02158979
46MAP3K61.02004536
47TAF10.97560024
48PAK10.96183419
49EPHA30.93680442
50GSK3A0.93379952
51MAP3K20.90623266
52FRK0.89547400
53SGK4940.88780908
54SGK2230.88780908
55TGFBR20.87348616
56STK38L0.86760469
57PRKG20.85950039
58WNK40.85605027
59MAP3K40.84494361
60MATK0.84253877
61PIK3CA0.79462686
62STK100.79072343
63SGK30.77751926
64KIT0.77107302
65CAMK1D0.77074051
66CSNK1A1L0.70564646
67MAPK40.70495775
68PRKCH0.69100287
69MAP3K120.67661335
70LIMK10.66131069
71PKN10.65383836
72PIM10.64349934
73PAK30.63387190
74PTK60.61345920
75PTK2B0.61261015
76FGFR20.61133675
77MAP3K100.61057405
78KSR20.60842643
79ROCK20.60608263
80NTRK10.59388684
81RPS6KA20.59003870
82CSNK1G10.58882596
83FGFR30.58424022
84MAPKAPK30.58361822
85FER0.57470758
86ERN10.57217198
87PRKCE0.54973967
88CDK90.52982952
89IGF1R0.49920300
90CAMK1G0.49294819
91PTK20.49266603
92MAPK100.49232609
93STK390.48444408
94MAP2K10.47179724
95PHKG10.46630928
96PHKG20.46630928
97MAPK140.46391197
98RET0.46142627
99PLK20.45917912
100CSK0.45702290
101LRRK20.44098552
102PDK40.43165761
103PDK30.43165761
104PRKD30.42248047
105PAK40.42136417
106PRKCQ0.41830329
107FYN0.40644255
108SCYL20.37300930
109STK380.36303480
110PRKACB0.35669081
111STK30.35529174
112CDK50.34823232
113TYRO30.33847117
114CAMK10.33598162
115MAPKAPK20.33551677
116NEK90.32151508
117PDK10.31250433
118PDGFRB0.31080932
119KDR0.30865183
120WNK10.30424920
121PRKAA20.30328138
122TEC0.30199876
123EIF2AK10.29505390
124EPHB10.29428918
125MTOR0.28990561
126YES10.28247345
127MAPK90.27654849
128PRKD10.27471827
129MAP3K70.27369374
130TGFBR10.26943516
131TRPM70.25815304
132FLT30.25681489
133MAPK30.25562520
134MAPK120.24553380
135ABL10.24219177
136ERBB40.24049665
137RPS6KC10.23818675
138RPS6KL10.23818675
139NEK10.23315798
140PDPK10.23251925
141CHUK0.21368750
142INSR0.20476511
143MAPKAPK50.20384790
144SRC0.20088751
145MOS0.20005170
146BCKDK0.19482197
147PDK20.17965319
148PRKAA10.16738226
149PAK60.15819276
150MELK0.15520272
151BMX0.15145663
152RPS6KA60.15142997
153TAOK10.14975369
154FGFR10.14553047
155PRKG10.13983222

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.46448790
2Focal adhesion_Homo sapiens_hsa045103.44183602
3Collecting duct acid secretion_Homo sapiens_hsa049663.42415141
4Vascular smooth muscle contraction_Homo sapiens_hsa042703.39188276
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.37219397
6Dilated cardiomyopathy_Homo sapiens_hsa054142.89131575
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.86652905
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.49653149
9Rheumatoid arthritis_Homo sapiens_hsa053232.37033106
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.35503501
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.33378599
12Protein digestion and absorption_Homo sapiens_hsa049742.32880653
13Platelet activation_Homo sapiens_hsa046111.86647669
14Vibrio cholerae infection_Homo sapiens_hsa051101.80354014
15cGMP-PKG signaling pathway_Homo sapiens_hsa040221.78193219
16Proteoglycans in cancer_Homo sapiens_hsa052051.74198913
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.64043357
18Fatty acid metabolism_Homo sapiens_hsa012121.58574710
19Gastric acid secretion_Homo sapiens_hsa049711.58042901
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57623881
21Oxytocin signaling pathway_Homo sapiens_hsa049211.57469790
22Amoebiasis_Homo sapiens_hsa051461.57467400
23PPAR signaling pathway_Homo sapiens_hsa033201.52981468
24Small cell lung cancer_Homo sapiens_hsa052221.49410213
25Prolactin signaling pathway_Homo sapiens_hsa049171.44191570
26Tight junction_Homo sapiens_hsa045301.38074689
27Fatty acid degradation_Homo sapiens_hsa000711.37262040
28Hedgehog signaling pathway_Homo sapiens_hsa043401.35836872
29Fatty acid biosynthesis_Homo sapiens_hsa000611.31546120
30Lysosome_Homo sapiens_hsa041421.31319733
31Colorectal cancer_Homo sapiens_hsa052101.27220475
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25712610
33Phagosome_Homo sapiens_hsa041451.24715598
34Osteoclast differentiation_Homo sapiens_hsa043801.23953773
35Ovarian steroidogenesis_Homo sapiens_hsa049131.22667505
36Propanoate metabolism_Homo sapiens_hsa006401.22483160
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19461478
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17789887
39Circadian rhythm_Homo sapiens_hsa047101.16618463
40Bile secretion_Homo sapiens_hsa049761.16120240
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.11912226
42Arachidonic acid metabolism_Homo sapiens_hsa005901.11461497
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10717819
44MicroRNAs in cancer_Homo sapiens_hsa052061.07622413
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05544785
46ABC transporters_Homo sapiens_hsa020101.04672768
47VEGF signaling pathway_Homo sapiens_hsa043701.04336934
48Adherens junction_Homo sapiens_hsa045201.03376172
49Prion diseases_Homo sapiens_hsa050201.00420685
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.97435971
51Renin secretion_Homo sapiens_hsa049240.97005026
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96181098
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.96093037
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96080330
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95893241
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95129177
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94581142
58Bladder cancer_Homo sapiens_hsa052190.91490560
59Pancreatic secretion_Homo sapiens_hsa049720.90068062
60Insulin resistance_Homo sapiens_hsa049310.89177841
61Hippo signaling pathway_Homo sapiens_hsa043900.89149062
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88329687
63Complement and coagulation cascades_Homo sapiens_hsa046100.87476043
64TGF-beta signaling pathway_Homo sapiens_hsa043500.85259721
65Estrogen signaling pathway_Homo sapiens_hsa049150.82032501
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81906816
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80032823
68AMPK signaling pathway_Homo sapiens_hsa041520.78001095
69Synaptic vesicle cycle_Homo sapiens_hsa047210.77534146
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77097761
71Glucagon signaling pathway_Homo sapiens_hsa049220.74628859
72GnRH signaling pathway_Homo sapiens_hsa049120.73484143
73Chemokine signaling pathway_Homo sapiens_hsa040620.72723331
74Cardiac muscle contraction_Homo sapiens_hsa042600.72434082
75Insulin secretion_Homo sapiens_hsa049110.70792955
76Melanogenesis_Homo sapiens_hsa049160.70605215
77Thyroid cancer_Homo sapiens_hsa052160.70562981
78Basal cell carcinoma_Homo sapiens_hsa052170.70153031
79Ras signaling pathway_Homo sapiens_hsa040140.68166947
80ErbB signaling pathway_Homo sapiens_hsa040120.68103262
81Rap1 signaling pathway_Homo sapiens_hsa040150.67702978
82Insulin signaling pathway_Homo sapiens_hsa049100.67673438
83Viral myocarditis_Homo sapiens_hsa054160.67075818
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65495989
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.64735250
86Gap junction_Homo sapiens_hsa045400.64510479
87cAMP signaling pathway_Homo sapiens_hsa040240.64455900
88Melanoma_Homo sapiens_hsa052180.63121699
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63070473
90Hematopoietic cell lineage_Homo sapiens_hsa046400.62947373
91Chronic myeloid leukemia_Homo sapiens_hsa052200.62809714
92Calcium signaling pathway_Homo sapiens_hsa040200.62249797
93Glioma_Homo sapiens_hsa052140.62180972
94Sulfur metabolism_Homo sapiens_hsa009200.61897146
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60379119
96Phenylalanine metabolism_Homo sapiens_hsa003600.59006035
97Nitrogen metabolism_Homo sapiens_hsa009100.58993937
98Pancreatic cancer_Homo sapiens_hsa052120.57991739
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56827374
100Glycerolipid metabolism_Homo sapiens_hsa005610.55761241
101Pyruvate metabolism_Homo sapiens_hsa006200.55375253
102Pathways in cancer_Homo sapiens_hsa052000.55065864
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55031848
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54598815
105Thyroid hormone synthesis_Homo sapiens_hsa049180.50982247
106Salivary secretion_Homo sapiens_hsa049700.49976976
107HIF-1 signaling pathway_Homo sapiens_hsa040660.49945012
108Axon guidance_Homo sapiens_hsa043600.49494073
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49360871
110FoxO signaling pathway_Homo sapiens_hsa040680.49129234
111Dorso-ventral axis formation_Homo sapiens_hsa043200.48927050
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47522496
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47460033
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.47265424
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46346181
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44856581
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44849179
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.43680933
119Carbon metabolism_Homo sapiens_hsa012000.43255736
120Prostate cancer_Homo sapiens_hsa052150.42323577
121Butanoate metabolism_Homo sapiens_hsa006500.42062243
122Lysine degradation_Homo sapiens_hsa003100.40181827
123Endometrial cancer_Homo sapiens_hsa052130.39700918
124Arginine biosynthesis_Homo sapiens_hsa002200.39003898
125Renal cell carcinoma_Homo sapiens_hsa052110.37962214
126* Wnt signaling pathway_Homo sapiens_hsa043100.37791595
127Toxoplasmosis_Homo sapiens_hsa051450.37342203
128Malaria_Homo sapiens_hsa051440.37099406
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35932863
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35284062
131mTOR signaling pathway_Homo sapiens_hsa041500.34415556
132Non-small cell lung cancer_Homo sapiens_hsa052230.34075549
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33860413
134Cholinergic synapse_Homo sapiens_hsa047250.32777842
135MAPK signaling pathway_Homo sapiens_hsa040100.31417085
136Acute myeloid leukemia_Homo sapiens_hsa052210.31129732
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28977543
138Endocytosis_Homo sapiens_hsa041440.28210629
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26285613
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25238009
141Tuberculosis_Homo sapiens_hsa051520.24919795
142Inositol phosphate metabolism_Homo sapiens_hsa005620.22773527
143Sphingolipid metabolism_Homo sapiens_hsa006000.19624916
144Renin-angiotensin system_Homo sapiens_hsa046140.18670676
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17982852
146Hepatitis B_Homo sapiens_hsa051610.16984163
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.16014217
148Starch and sucrose metabolism_Homo sapiens_hsa005000.15799349
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.15374127
150HTLV-I infection_Homo sapiens_hsa051660.13642393

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