SOSTDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)9.76050990
2kidney mesenchyme development (GO:0072074)8.37186231
3hemidesmosome assembly (GO:0031581)8.15057806
4lateral sprouting from an epithelium (GO:0060601)7.92690833
5generation of neurons (GO:0048699)7.69755179
6keratinocyte proliferation (GO:0043616)7.64753924
7peripheral nervous system neuron development (GO:0048935)7.25198496
8myoblast migration (GO:0051451)7.02741097
9segment specification (GO:0007379)6.44414146
10proximal/distal pattern formation (GO:0009954)6.11045172
11desmosome organization (GO:0002934)6.07777711
12regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.84530325
13negative regulation of keratinocyte proliferation (GO:0010839)5.76887905
14mesenchymal-epithelial cell signaling (GO:0060638)5.51419821
15organ induction (GO:0001759)5.36534477
16regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.30622565
17regulation of keratinocyte proliferation (GO:0010837)5.14115293
18regulation of transforming growth factor beta2 production (GO:0032909)5.06084923
19planar cell polarity pathway involved in neural tube closure (GO:0090179)5.05735000
20cranial nerve morphogenesis (GO:0021602)5.01483457
21regulation of cardioblast differentiation (GO:0051890)5.01297659
22cellular response to vitamin D (GO:0071305)4.85867186
23embryonic skeletal joint morphogenesis (GO:0060272)4.76461315
24prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.65387646
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.63618689
26regulation of cardioblast proliferation (GO:0003264)4.57819351
27regulation of secondary heart field cardioblast proliferation (GO:0003266)4.57819351
28limb bud formation (GO:0060174)4.46826499
29neuron projection extension involved in neuron projection guidance (GO:1902284)4.46013315
30axon extension involved in axon guidance (GO:0048846)4.46013315
31branching involved in labyrinthine layer morphogenesis (GO:0060670)4.37150966
32metanephric nephron tubule development (GO:0072234)4.23301304
33metanephric tubule development (GO:0072170)4.23301304
34establishment of skin barrier (GO:0061436)4.14935873
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.12220355
36forelimb morphogenesis (GO:0035136)4.08544437
37radial glial cell differentiation (GO:0060019)4.06606019
38mesenchyme morphogenesis (GO:0072132)4.00640939
39exocrine pancreas development (GO:0031017)3.99960511
40short-term memory (GO:0007614)3.96733398
41limb development (GO:0060173)3.94753004
42appendage development (GO:0048736)3.94753004
43regulation of phospholipase A2 activity (GO:0032429)3.90660858
44positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.89755713
45branching involved in salivary gland morphogenesis (GO:0060445)3.89432633
46regulation of heart morphogenesis (GO:2000826)3.87435808
47nephron tubule formation (GO:0072079)3.84174586
48regulation of water loss via skin (GO:0033561)3.83116994
49ribosomal small subunit biogenesis (GO:0042274)3.77046386
50embryonic forelimb morphogenesis (GO:0035115)3.76689275
51metanephric nephron epithelium development (GO:0072243)3.74191320
52metanephric epithelium development (GO:0072207)3.71921396
53thyroid gland development (GO:0030878)3.71768027
54positive regulation of embryonic development (GO:0040019)3.70249426
55negative regulation of kidney development (GO:0090185)3.65764654
56regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.63860412
57cellular response to vitamin (GO:0071295)3.62749498
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60069319
59regulation of organ formation (GO:0003156)3.58580984
60paraxial mesoderm development (GO:0048339)3.57109235
61embryonic digestive tract development (GO:0048566)3.53042855
62cell proliferation involved in metanephros development (GO:0072203)3.50469664
63* hair follicle morphogenesis (GO:0031069)3.49925446
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48009485
65otic vesicle formation (GO:0030916)3.47160037
66negative regulation of catenin import into nucleus (GO:0035414)3.44127409
67mesenchymal cell proliferation (GO:0010463)3.43191296
68embryonic skeletal system morphogenesis (GO:0048704)3.43003364
69digestive tract morphogenesis (GO:0048546)3.42790739
70negative regulation of osteoblast proliferation (GO:0033689)3.40300052
71regulation of apoptotic process involved in morphogenesis (GO:1902337)3.39258711
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38876237
73cell proliferation involved in kidney development (GO:0072111)3.37859683
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37640638
75viral transcription (GO:0019083)3.36057707
76positive regulation of mesonephros development (GO:0061213)3.35425501
77hindlimb morphogenesis (GO:0035137)3.33972782
78neuron fate specification (GO:0048665)3.33265345
79epidermis development (GO:0008544)3.32415271
80regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.30346343
81positive regulation of p38MAPK cascade (GO:1900745)3.29037123
82collecting duct development (GO:0072044)3.26206536
83muscle cell migration (GO:0014812)3.25267532
84craniofacial suture morphogenesis (GO:0097094)3.24874991
85positive regulation of gastrulation (GO:2000543)3.24676119
86somite development (GO:0061053)3.21055782
87maturation of SSU-rRNA (GO:0030490)3.20937235
88positive regulation of vesicle fusion (GO:0031340)3.20172299
89polyol transport (GO:0015791)3.19581639
90developmental induction (GO:0031128)3.19555289
91retinal ganglion cell axon guidance (GO:0031290)3.18800771
92mesenchymal cell development (GO:0014031)3.18555285
93keratinocyte development (GO:0003334)3.17982261
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17869566
95neuron fate determination (GO:0048664)3.16325913
96positive regulation of chondrocyte differentiation (GO:0032332)3.12172989
97renal absorption (GO:0070293)3.11088440
98translational termination (GO:0006415)3.10979410
99outer ear morphogenesis (GO:0042473)3.10965611
100regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.10464009
101skeletal muscle tissue development (GO:0007519)3.09991075
102neural crest cell development (GO:0014032)3.09066558
103middle ear morphogenesis (GO:0042474)3.07949986
104mammary gland epithelial cell differentiation (GO:0060644)3.06759587
105positive regulation of dendritic spine morphogenesis (GO:0061003)3.06461677
106branching involved in prostate gland morphogenesis (GO:0060442)3.05423998
107cell-cell signaling involved in cell fate commitment (GO:0045168)3.04976724
108non-canonical Wnt signaling pathway (GO:0035567)3.02692865
109regulation of establishment of planar polarity (GO:0090175)3.00401613
110regulation of morphogenesis of a branching structure (GO:0060688)2.99612325
111multicellular organismal water homeostasis (GO:0050891)2.97902445
112renal system development (GO:0072001)2.96829010
113peripheral nervous system axon ensheathment (GO:0032292)2.96638011
114myelination in peripheral nervous system (GO:0022011)2.96638011
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.96630713
116somatic stem cell division (GO:0048103)2.96415449
117positive regulation of keratinocyte differentiation (GO:0045618)2.96018812
118mesonephros development (GO:0001823)2.95689538
119sequestering of extracellular ligand from receptor (GO:0035581)2.95204670
120oligosaccharide biosynthetic process (GO:0009312)2.95113576
121keratinization (GO:0031424)2.94428127
122mesenchymal cell differentiation (GO:0048762)2.91841457
123regulation of mesonephros development (GO:0061217)2.91838090
124lung-associated mesenchyme development (GO:0060484)2.91715476
125cochlea morphogenesis (GO:0090103)2.90482963
126aorta morphogenesis (GO:0035909)2.90477239
127pharyngeal system development (GO:0060037)2.90415080
128mammary gland development (GO:0030879)2.90009467
129mesenchyme development (GO:0060485)2.89037786
130embryonic cranial skeleton morphogenesis (GO:0048701)2.88891445
131* hair cycle process (GO:0022405)2.88740117
132* molting cycle process (GO:0022404)2.88740117
133metanephros development (GO:0001656)2.87184753
134organ formation (GO:0048645)2.87005488
135gland morphogenesis (GO:0022612)2.84795636
136urogenital system development (GO:0001655)2.84377369
137neurogenesis (GO:0022008)2.83918094
138keratinocyte differentiation (GO:0030216)2.83746826
139embryonic skeletal system development (GO:0048706)2.80563129
140regulation of keratinocyte differentiation (GO:0045616)2.80380093
141ureteric bud development (GO:0001657)2.80296240
142prostate gland epithelium morphogenesis (GO:0060740)2.80011141
143skeletal system morphogenesis (GO:0048705)2.79538183
144* odontogenesis (GO:0042476)2.79352748
145regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78563433
146one-carbon compound transport (GO:0019755)2.77297783
147cardiac right ventricle morphogenesis (GO:0003215)2.76789083
148embryonic organ morphogenesis (GO:0048562)2.75533506
149nucleobase catabolic process (GO:0046113)2.75239466
150sphingosine metabolic process (GO:0006670)2.73943381
151regulation of heart rate by cardiac conduction (GO:0086091)2.73719873
152regulation of pigment cell differentiation (GO:0050932)2.73572020
153regulation of chemokine-mediated signaling pathway (GO:0070099)2.73129965
154response to vitamin D (GO:0033280)2.72639794
155notochord development (GO:0030903)2.72475142
156digestion (GO:0007586)2.71932353
157glomerular filtration (GO:0003094)2.70703311
158intermediate filament organization (GO:0045109)2.70255578
159regulation of hair follicle development (GO:0051797)2.68126096
160positive regulation of cartilage development (GO:0061036)2.67939467
161cell-substrate junction assembly (GO:0007044)2.67392576
162negative regulation of chondrocyte differentiation (GO:0032331)2.66807031
163regulation of kidney development (GO:0090183)2.66459143
164branch elongation of an epithelium (GO:0060602)2.64268575
165sympathetic nervous system development (GO:0048485)2.63663531
166stem cell development (GO:0048864)2.62424559
167hair cycle (GO:0042633)2.61572001
168molting cycle (GO:0042303)2.61572001
169hair follicle development (GO:0001942)2.59418451
170bone trabecula formation (GO:0060346)2.58902640
171cellular response to cholesterol (GO:0071397)2.56580937
172regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.56319862
173positive regulation of epidermal cell differentiation (GO:0045606)2.55732212
174atrioventricular valve morphogenesis (GO:0003181)2.55059682
175glial cell migration (GO:0008347)2.53076009
176SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.52983040
177lymph vessel development (GO:0001945)2.52431197
178cellular response to sterol (GO:0036315)2.51261530
179protein targeting to ER (GO:0045047)2.49557305
180head development (GO:0060322)2.49528434
181cotranslational protein targeting to membrane (GO:0006613)2.49493769
182heart valve morphogenesis (GO:0003179)2.49319152
183positive regulation of hair follicle development (GO:0051798)2.48995509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.72059172
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.16313109
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.81489331
4AR_21572438_ChIP-Seq_LNCaP_Human2.79002600
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.54523887
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52342307
7FUS_26573619_Chip-Seq_HEK293_Human2.51849575
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47233434
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37919087
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33587664
11IGF1R_20145208_ChIP-Seq_DFB_Human2.32310848
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22117314
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11403427
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11403427
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10823210
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08209819
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08187745
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03252879
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01205487
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.01052134
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98726898
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.93149351
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.90045333
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83161860
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.82774645
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82549282
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.79762688
28RNF2_27304074_Chip-Seq_NSC_Mouse1.79264496
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77826599
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75874935
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74465735
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.73953072
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72692924
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.69177860
35STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.67593576
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66296624
37TP53_18474530_ChIP-ChIP_U2OS_Human1.63591824
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61630770
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59199727
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57869977
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57094305
42* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55909395
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52695732
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.51592186
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49975131
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49163486
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46651090
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42268240
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41489929
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38359585
51RXR_22108803_ChIP-Seq_LS180_Human1.37314311
52BCAT_22108803_ChIP-Seq_LS180_Human1.37220335
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36238441
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.35247408
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34621430
56AHR_22903824_ChIP-Seq_MCF-7_Human1.34538021
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32864598
58CJUN_26792858_Chip-Seq_BT549_Human1.31178506
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.28299607
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.24909939
61TAF15_26573619_Chip-Seq_HEK293_Human1.24260260
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22679023
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19760885
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.19148103
65* EP300_21415370_ChIP-Seq_HL-1_Mouse1.15897500
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15766408
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15766408
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15766408
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.15636236
70TP53_16413492_ChIP-PET_HCT116_Human1.15010098
71SOX9_26525672_Chip-Seq_HEART_Mouse1.13069232
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.12946928
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12568267
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.12011052
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11631543
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11102808
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10668809
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07593457
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.05663801
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04422795
81* SOX2_20726797_ChIP-Seq_SW620_Human1.04267194
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04249125
83VDR_22108803_ChIP-Seq_LS180_Human1.03882912
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03739549
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.03707004
86P300_19829295_ChIP-Seq_ESCs_Human1.02506031
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02403471
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02403471
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02284498
90TP63_23658742_ChIP-Seq_EP156T_Human1.01499674
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01069980
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00655434
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99022227
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99022227
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99003418
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98227227
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.97440588
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.97324874
99TBL1_22424771_ChIP-Seq_293T_Human0.94844245
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94773017
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94704801
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94589406
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94299889
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.94286477
105SMAD4_21799915_ChIP-Seq_A2780_Human0.94128294
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93329446
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93072588
108STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92649805
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92035692
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.91996860
111EZH2_22144423_ChIP-Seq_EOC_Human0.91640811
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.91025305
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90825515
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90010930
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.89902442
116* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89350280
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89310183
118HTT_18923047_ChIP-ChIP_STHdh_Human0.89298720
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89177502
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88939773
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87998604
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86936947
123KLF5_25053715_ChIP-Seq_YYC3_Human0.86746742
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86734642
125TCF4_22108803_ChIP-Seq_LS180_Human0.86335795
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.85909239
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85416773
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84893568
129* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84563849
130GBX2_23144817_ChIP-Seq_PC3_Human0.84373712
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84133706
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.83578777
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83259262
134* AR_25329375_ChIP-Seq_VCAP_Human0.83055551
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82400594
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82400594
137PHF8_20622853_ChIP-Seq_HELA_Human0.81603513
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79501643
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78492146
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77856483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland3.28305001
2MP0002098_abnormal_vibrissa_morphology3.19870859
3MP0004381_abnormal_hair_follicle3.19869421
4MP0003941_abnormal_skin_development3.09756136
5MP0000579_abnormal_nail_morphology3.04703855
6MP0002796_impaired_skin_barrier2.99259491
7MP0004272_abnormal_basement_membrane2.93144667
8MP0004147_increased_porphyrin_level2.89596562
9MP0000762_abnormal_tongue_morphology2.75664006
10MP0008438_abnormal_cutaneous_collagen2.69896915
11MP0002254_reproductive_system_inflammat2.68889632
12MP0000383_abnormal_hair_follicle2.66566033
13MP0000427_abnormal_hair_cycle2.61486266
14MP0000647_abnormal_sebaceous_gland2.55091829
15MP0000537_abnormal_urethra_morphology2.50507222
16MP0001881_abnormal_mammary_gland2.44997631
17MP0002938_white_spotting2.44381570
18MP0002822_catalepsy2.41806457
19MP0010030_abnormal_orbit_morphology2.39413442
20MP0001299_abnormal_eye_distance/2.37721109
21MP0000566_synostosis2.35467524
22MP0002060_abnormal_skin_morphology2.33679699
23MP0002282_abnormal_trachea_morphology2.32235138
24MP0000733_abnormal_muscle_development2.26215450
25MP0003136_yellow_coat_color2.19799584
26MP0009250_abnormal_appendicular_skeleto2.10236607
27MP0010678_abnormal_skin_adnexa2.05003596
28MP0005187_abnormal_penis_morphology2.04601433
29MP0001216_abnormal_epidermal_layer2.02908712
30MP0000377_abnormal_hair_follicle2.02153458
31MP0001666_abnormal_nutrient_absorption2.00260063
32MP0005503_abnormal_tendon_morphology1.98991067
33MP0002932_abnormal_joint_morphology1.97116875
34MP0003705_abnormal_hypodermis_morpholog1.87699601
35MP0005275_abnormal_skin_tensile1.83922192
36MP0002396_abnormal_hematopoietic_system1.82966849
37MP0002249_abnormal_larynx_morphology1.76724768
38MP0000428_abnormal_craniofacial_morphol1.76319522
39MP0002102_abnormal_ear_morphology1.70308501
40MP0002108_abnormal_muscle_morphology1.69051145
41MP0002009_preneoplasia1.68473969
42MP0009384_cardiac_valve_regurgitation1.66966366
43MP0010234_abnormal_vibrissa_follicle1.63013855
44MP0005501_abnormal_skin_physiology1.61163444
45MP0004019_abnormal_vitamin_homeostasis1.56105197
46MP0004742_abnormal_vestibular_system1.55981195
47MP0003718_maternal_effect1.55546896
48MP0001340_abnormal_eyelid_morphology1.55256568
49MP0000467_abnormal_esophagus_morphology1.54968156
50MP0010771_integument_phenotype1.54173687
51MP0000049_abnormal_middle_ear1.53649220
52MP0009053_abnormal_anal_canal1.49884126
53MP0005220_abnormal_exocrine_pancreas1.48443525
54MP0003115_abnormal_respiratory_system1.48245636
55MP0002837_dystrophic_cardiac_calcinosis1.48201081
56MP0005508_abnormal_skeleton_morphology1.46420547
57MP0005451_abnormal_body_composition1.45938559
58MP0003938_abnormal_ear_development1.38494069
59MP0009379_abnormal_foot_pigmentation1.38320791
60MP0008789_abnormal_olfactory_epithelium1.37791143
61MP0000516_abnormal_urinary_system1.36930446
62MP0005367_renal/urinary_system_phenotyp1.36930446
63MP0003011_delayed_dark_adaptation1.33266542
64MP0005171_absent_coat_pigmentation1.32767215
65MP0000538_abnormal_urinary_bladder1.32672003
66MP0003453_abnormal_keratinocyte_physiol1.32487280
67MP0004043_abnormal_pH_regulation1.30616545
68MP0004133_heterotaxia1.29530203
69MP0002184_abnormal_innervation1.26738649
70MP0003119_abnormal_digestive_system1.26391158
71MP0003942_abnormal_urinary_system1.26336402
72MP0001270_distended_abdomen1.24806308
73MP0001849_ear_inflammation1.23008829
74MP0001188_hyperpigmentation1.22800745
75MP0000367_abnormal_coat/_hair1.21343540
76MP0003878_abnormal_ear_physiology1.21292726
77MP0005377_hearing/vestibular/ear_phenot1.21292726
78MP0005248_abnormal_Harderian_gland1.21159498
79MP0003195_calcinosis1.19151287
80MP0003638_abnormal_response/metabolism_1.17981811
81MP0001286_abnormal_eye_development1.17789392
82MP0002233_abnormal_nose_morphology1.17248861
83MP0001191_abnormal_skin_condition1.16493340
84* MP0003755_abnormal_palate_morphology1.16243356
85MP0002114_abnormal_axial_skeleton1.16195115
86MP0002653_abnormal_ependyma_morphology1.14796811
87MP0003937_abnormal_limbs/digits/tail_de1.14612109
88MP0001485_abnormal_pinna_reflex1.14330965
89MP0002177_abnormal_outer_ear1.13597874
90MP0005075_abnormal_melanosome_morpholog1.13349088
91MP0002111_abnormal_tail_morphology1.11930493
92MP0003385_abnormal_body_wall1.11866784
93MP0001243_abnormal_dermal_layer1.09517212
94MP0000163_abnormal_cartilage_morphology1.08946784
95MP0005083_abnormal_biliary_tract1.08894021
96MP0000462_abnormal_digestive_system1.08317072
97MP0002896_abnormal_bone_mineralization1.08067021
98MP0003045_fibrosis1.07693645
99MP0002168_other_aberrant_phenotype1.04611341
100MP0000678_abnormal_parathyroid_gland1.04384037
101MP0003935_abnormal_craniofacial_develop1.03757935
102MP0005499_abnormal_olfactory_system1.03338158
103MP0005394_taste/olfaction_phenotype1.03338158
104MP0004885_abnormal_endolymph1.03226135
105MP0001293_anophthalmia1.03159480
106MP0000955_abnormal_spinal_cord1.02228833
107MP0009931_abnormal_skin_appearance1.00294804
108MP0003566_abnormal_cell_adhesion0.99900629
109* MP0000432_abnormal_head_morphology0.99702545
110MP0000372_irregular_coat_pigmentation0.98538297
111MP0003890_abnormal_embryonic-extraembry0.98387348
112MP0004947_skin_inflammation0.98312369
113MP0000026_abnormal_inner_ear0.97945225
114MP0002115_abnormal_skeleton_extremities0.96299754
115MP0002109_abnormal_limb_morphology0.96131816
116MP0000778_abnormal_nervous_system0.95606694
117MP0001756_abnormal_urination0.92956897
118* MP0002116_abnormal_craniofacial_bone0.89615744
119MP0003300_gastrointestinal_ulcer0.89345446
120MP0001851_eye_inflammation0.87640056
121MP0000613_abnormal_salivary_gland0.86460322
122MP0005388_respiratory_system_phenotype0.85384745
123MP0002133_abnormal_respiratory_system0.85384745
124MP0001984_abnormal_olfaction0.83565070
125* MP0002752_abnormal_somatic_nervous0.83410207
126MP0002085_abnormal_embryonic_tissue0.82892166
127MP0008770_decreased_survivor_rate0.81012266
128MP0002735_abnormal_chemical_nociception0.80369988
129MP0000470_abnormal_stomach_morphology0.78210066
130MP0006072_abnormal_retinal_apoptosis0.77412059
131MP0003861_abnormal_nervous_system0.76178855
132MP0003315_abnormal_perineum_morphology0.75880918
133MP0001661_extended_life_span0.74684457
134MP0009643_abnormal_urine_homeostasis0.71874104
135MP0001177_atelectasis0.70159202
136MP0000534_abnormal_ureter_morphology0.69755155
137MP0002132_abnormal_respiratory_system0.69353308
138MP0002277_abnormal_respiratory_mucosa0.69158273
139MP0003879_abnormal_hair_cell0.68459876
140MP0005197_abnormal_uvea_morphology0.68204500
141MP0000759_abnormal_skeletal_muscle0.67573517
142MP0002697_abnormal_eye_size0.65283868
143MP0009780_abnormal_chondrocyte_physiolo0.64903313
144MP0001879_abnormal_lymphatic_vessel0.64699281
145MP0005395_other_phenotype0.60720126

Predicted human phenotypes

RankGene SetZ-score
1Calcaneovalgus deformity (HP:0001848)7.42848868
2Deformed tarsal bones (HP:0008119)6.59260329
3Down-sloping shoulders (HP:0200021)5.14772837
4Abnormality of the parietal bone (HP:0002696)5.07560230
5Abnormality of the calcaneus (HP:0008364)5.04110522
6Fragile nails (HP:0001808)4.99504695
7Milia (HP:0001056)4.91481361
8Midline defect of the nose (HP:0004122)4.64720667
9Concave nail (HP:0001598)4.30606865
10Nasolacrimal duct obstruction (HP:0000579)4.22019780
11Short middle phalanx of the 5th finger (HP:0004220)3.91237338
12Aplasia cutis congenita (HP:0001057)3.88144497
13Abnormality of the nasal septum (HP:0000419)3.85850056
14Premature rupture of membranes (HP:0001788)3.83519660
15Onycholysis (HP:0001806)3.65539274
16Abnormality of the lacrimal duct (HP:0011481)3.61266142
17Aplasia involving bones of the upper limbs (HP:0009823)3.59023168
18Aplasia of the phalanges of the hand (HP:0009802)3.59023168
19Aplasia involving bones of the extremities (HP:0009825)3.59023168
20Hypotrichosis (HP:0001006)3.56883113
21Aortic dissection (HP:0002647)3.51289036
22Short 4th metacarpal (HP:0010044)3.50092837
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.50092837
24Plantar hyperkeratosis (HP:0007556)3.49619785
25Atrophic scars (HP:0001075)3.41133271
26Hyperaldosteronism (HP:0000859)3.40128353
27Atrioventricular block (HP:0001678)3.31671163
28Abnormality of the nasolacrimal system (HP:0000614)3.25070066
29Humeroradial synostosis (HP:0003041)3.19301338
30Synostosis involving the elbow (HP:0003938)3.19301338
31Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.08934628
32Arterial tortuosity (HP:0005116)3.06987705
33White forelock (HP:0002211)3.00572314
34Metabolic alkalosis (HP:0200114)2.94137926
35Prolonged QT interval (HP:0001657)2.92729741
36Premature skin wrinkling (HP:0100678)2.91789599
37Bladder diverticulum (HP:0000015)2.90253043
38Abnormality of nail color (HP:0100643)2.85784792
39Coronal craniosynostosis (HP:0004440)2.85499535
40Trigonocephaly (HP:0000243)2.84648872
41Abnormality of the middle phalanges of the toes (HP:0010183)2.84221106
42Alacrima (HP:0000522)2.81877467
43Vascular tortuosity (HP:0004948)2.79870273
44Alopecia of scalp (HP:0002293)2.79111281
45Mitral valve prolapse (HP:0001634)2.78279597
46Toxemia of pregnancy (HP:0100603)2.75887253
47Parakeratosis (HP:0001036)2.74929757
48Conical tooth (HP:0000698)2.74881456
49Shallow orbits (HP:0000586)2.73681846
50Hypokalemic alkalosis (HP:0001949)2.66259343
51Patchy hypopigmentation of hair (HP:0011365)2.64812391
52Renal salt wasting (HP:0000127)2.62878449
53Infantile muscular hypotonia (HP:0008947)2.62818755
54Pili torti (HP:0003777)2.62817029
55Sparse scalp hair (HP:0002209)2.62282312
56Fragile skin (HP:0001030)2.60754862
57Premature loss of primary teeth (HP:0006323)2.58458243
58Short 5th finger (HP:0009237)2.57811231
59Sparse lateral eyebrow (HP:0005338)2.55233417
60Acute lymphatic leukemia (HP:0006721)2.54170400
61Atonic seizures (HP:0010819)2.52559533
62Bronchomalacia (HP:0002780)2.52528881
63Increased circulating renin level (HP:0000848)2.49042150
64Hypokalemia (HP:0002900)2.48521875
65Abnormality of the middle phalanges of the hand (HP:0009833)2.46811363
66Amelogenesis imperfecta (HP:0000705)2.45713454
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.45580760
68Lip pit (HP:0100267)2.43489813
69Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.43404517
70Hypoplastic labia majora (HP:0000059)2.43042235
71Partial duplication of thumb phalanx (HP:0009944)2.42204445
72Hypomagnesemia (HP:0002917)2.41865580
73Hypoplasia of dental enamel (HP:0006297)2.41598795
74Abnormality of renin-angiotensin system (HP:0000847)2.39672560
75Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.38971672
76Partial duplication of the phalanx of hand (HP:0009999)2.37088319
77Abnormality of the costochondral junction (HP:0000919)2.36431906
78Mixed hearing impairment (HP:0000410)2.34666632
79Widely patent fontanelles and sutures (HP:0004492)2.32080263
80Anophthalmia (HP:0000528)2.29791559
81Abnormality of the 4th metacarpal (HP:0010012)2.27094934
82Broad metatarsal (HP:0001783)2.27014147
83Upper limb muscle weakness (HP:0003484)2.25783412
84Anteriorly placed anus (HP:0001545)2.21633576
85Abnormality of incisor morphology (HP:0011063)2.20151126
86Woolly hair (HP:0002224)2.19490737
87Hypoplastic left heart (HP:0004383)2.18625344
88Abnormality of the axillary hair (HP:0100134)2.18325707
89Abnormality of secondary sexual hair (HP:0009888)2.18325707
90Soft skin (HP:0000977)2.18222647
91Abnormality of the labia majora (HP:0012881)2.17150746
92Short phalanx of the thumb (HP:0009660)2.15977338
93Spondylolisthesis (HP:0003302)2.15531096
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14076566
95Preauricular pit (HP:0004467)2.12030501
96Periauricular skin pits (HP:0100277)2.12030501
97Broad hallux (HP:0010055)2.11513336
98Genu recurvatum (HP:0002816)2.11101788
99Erythroderma (HP:0001019)2.10844871
100Cutaneous syndactyly (HP:0012725)2.09442580
101Congenital ichthyosiform erythroderma (HP:0007431)2.07231877
102Turricephaly (HP:0000262)2.06906957
103Decreased lacrimation (HP:0000633)2.06198549
104Ridged nail (HP:0001807)2.05861884
105Absent eyebrow (HP:0002223)2.05474027
106Vitreoretinal degeneration (HP:0000655)2.04857424
107Type I diabetes mellitus (HP:0100651)2.04758226
108Protrusio acetabuli (HP:0003179)2.03131992
109Abnormality of the distal phalanx of the thumb (HP:0009617)2.02869791
110Hypodontia (HP:0000668)2.02265360
111Esophageal atresia (HP:0002032)2.01700599
112Abnormality of the distal phalanges of the toes (HP:0010182)2.01253911
113Peritonitis (HP:0002586)2.00212338
114Skin pits (HP:0100276)1.99864089
115Aqueductal stenosis (HP:0002410)1.98842844
116Neoplasm of the heart (HP:0100544)1.98809215
117Focal motor seizures (HP:0011153)1.98259247
118Abnormality of permanent molar morphology (HP:0011071)1.97051036
119Abnormality of the dental root (HP:0006486)1.97051036
120Taurodontia (HP:0000679)1.97051036
121Ulnar claw (HP:0001178)1.96590147
122Broad toe (HP:0001837)1.96470518
123Pterygium (HP:0001059)1.96392517
124Abnormality of renal excretion (HP:0011036)1.95574954
125Decreased circulating renin level (HP:0003351)1.95212479
126Heart block (HP:0012722)1.94957644
127Recurrent corneal erosions (HP:0000495)1.94482796
128Right ventricular cardiomyopathy (HP:0011663)1.94017138
129Shawl scrotum (HP:0000049)1.92731536
130Abnormality of molar (HP:0011077)1.92651842
131Abnormality of molar morphology (HP:0011070)1.92651842
132Abnormality of cells of the erythroid lineage (HP:0012130)1.92099379
133Choanal stenosis (HP:0000452)1.92049266
134Cutaneous finger syndactyly (HP:0010554)1.91187904
135Abnormality of the phalanges of the 5th finger (HP:0004213)1.90818418
136Hyperactive renin-angiotensin system (HP:0000841)1.90327043
137Abnormal hair laboratory examination (HP:0003328)1.89091410
138Coarctation of aorta (HP:0001680)1.89058644
139Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88614770
140Bifid scrotum (HP:0000048)1.88118047
141Oligodontia (HP:0000677)1.87387723
142Natal tooth (HP:0000695)1.87106710
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.85216675
144Thin bony cortex (HP:0002753)1.84967169
145Microglossia (HP:0000171)1.84656904
146Supernumerary ribs (HP:0005815)1.84496552
147Abnormality of chloride homeostasis (HP:0011422)1.84317075
148Morphological abnormality of the middle ear (HP:0008609)1.82115435
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81986136
150Hallux valgus (HP:0001822)1.80362432
151Increased number of teeth (HP:0011069)1.78995610
152Atresia of the external auditory canal (HP:0000413)1.77448624
153Short middle phalanx of finger (HP:0005819)1.75737971
154Abnormality of sodium homeostasis (HP:0010931)1.75626714
155Deviation of the hallux (HP:0010051)1.74823986
156Abnormality of potassium homeostasis (HP:0011042)1.73143309
157Abnormal atrioventricular conduction (HP:0005150)1.71375540
158Bifid tongue (HP:0010297)1.69188145
159Hyponatremia (HP:0002902)1.68567900
160Absent eyelashes (HP:0000561)1.67897848
161Occipital encephalocele (HP:0002085)1.65016674
162Tubulointerstitial fibrosis (HP:0005576)1.62430899
163Abnormality of dentin (HP:0010299)1.61163863
164Hypoplastic heart (HP:0001961)1.58197166
165Nausea (HP:0002018)1.56462751
166Palmoplantar hyperkeratosis (HP:0000972)1.54002107
167Renal dysplasia (HP:0000110)1.53060565
168High anterior hairline (HP:0009890)1.52836531
169Facial shape deformation (HP:0011334)1.52287007
170Potter facies (HP:0002009)1.52287007
171Abnormality of purine metabolism (HP:0004352)1.51497182
172Bell-shaped thorax (HP:0001591)1.48475481
173Acanthocytosis (HP:0001927)1.48335192
174Nephritis (HP:0000123)1.47799201
175Aplasia/Hypoplasia of the lens (HP:0008063)1.47168895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.56428631
2STK38L4.49449069
3FGFR24.28779208
4LATS13.81800000
5WNK43.69365525
6MST1R3.50939277
7MKNK23.38818815
8WNK33.26862599
9EPHA32.93818570
10MKNK12.88180414
11OXSR12.49262996
12NUAK12.04580701
13MAPKAPK31.97394255
14STK381.95172547
15FER1.84828996
16MAP3K31.81222355
17STK391.79968224
18FGFR11.77970159
19MAPK151.77492345
20SIK11.74165949
21ERN11.71397151
22MAP3K21.68372076
23MST41.57373706
24LRRK21.57147705
25BCKDK1.53981159
26IRAK11.45217827
27DDR21.42547655
28STK241.31130589
29IRAK21.26003418
30FGFR41.20505540
31PTK61.19506791
32MET1.16109219
33ACVR1B1.14134878
34FRK1.13867637
35KSR21.12895534
36TTK1.12090111
37WNK11.10420054
38MAPKAPK51.09104829
39DMPK1.09068649
40EPHB11.08973741
41NLK1.07768963
42MAP3K61.06363304
43MOS1.03355143
44MAP3K41.03199832
45NTRK21.01572469
46PRKD31.00698976
47NTRK30.96357890
48RAF10.95965636
49CDK30.95799913
50PAK60.94674024
51BMX0.94254699
52BMPR1B0.93256384
53PIK3CG0.92548340
54MELK0.92296437
55MAP2K20.91865028
56SGK2230.91237164
57SGK4940.91237164
58TRPM70.89512808
59PDGFRA0.88765346
60PRKCE0.88697238
61INSRR0.88394507
62CLK10.87022789
63RPS6KB20.85643896
64PDGFRB0.77798382
65TNK20.76954088
66FGFR30.75935701
67NTRK10.75640601
68NEK10.75080736
69FLT30.71518659
70EEF2K0.70645876
71RET0.69572974
72PIK3CA0.69370260
73TGFBR20.69323044
74DAPK20.67842198
75NME10.66336403
76ICK0.63188858
77SGK20.62627268
78TAF10.62208752
79STK30.61525005
80NEK90.61447684
81STK110.55259402
82HIPK20.54292851
83CDK190.54068616
84ROCK20.53033524
85ADRBK10.52532946
86SIK20.52256756
87CCNB10.52146594
88ERBB20.50930637
89ROCK10.50170708
90MAP2K10.49883467
91PTK20.49499408
92BRD40.49442338
93NEK20.49110746
94PRKD10.47983416
95PASK0.47182371
96DYRK1B0.43599604
97GSK3A0.43570686
98PRKCQ0.43569456
99JAK10.43106692
100JAK20.43004929
101ERBB40.42800688
102PRKAA20.42075505
103MAP2K70.42071862
104PRKCZ0.41926865
105GRK50.41685760
106MAP3K70.41193765
107CDK80.40986634
108TNIK0.39143819
109EPHA40.38981060
110CASK0.38793960
111EIF2AK20.38771437
112TYK20.38737516
113PKN20.38301234
114CSNK1A1L0.38059013
115CDK50.36997494
116MAPK70.36845437
117LATS20.36494510
118CDK60.35975928
119ILK0.35559123
120IGF1R0.35389313
121TSSK60.35316883
122CDK150.34733619
123CDK11A0.34131809
124ERBB30.33861357
125MATK0.33049007
126MAPK100.32873717
127CAMK40.32511022
128TGFBR10.32454718
129MTOR0.32411794
130PRKCH0.32390426
131CDK180.31981726
132NEK60.31912475
133PRKG10.30229868
134MAPK30.30129899
135CSNK1D0.30042527
136DYRK1A0.29638555
137PAK20.29051852
138DYRK20.28868389
139RIPK10.28793879
140CSNK1G20.28781920
141MARK20.28646159
142PRKACB0.28575186
143EIF2AK10.28331088
144PRKACA0.28257850
145SGK10.28157639
146PDK20.28052859
147MAP3K10.27679612
148CSNK1A10.27189621
149SRPK10.27179497
150CHUK0.26744837
151PRKCA0.25248258
152SRC0.24815473
153TRIB30.23427777
154PRKCI0.23201425
155CDK140.21627921

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002327.53663613
2Protein digestion and absorption_Homo sapiens_hsa049743.81574937
3Basal cell carcinoma_Homo sapiens_hsa052173.77277182
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.53736745
5Hedgehog signaling pathway_Homo sapiens_hsa043403.44736939
6Fatty acid biosynthesis_Homo sapiens_hsa000613.24411957
7Pancreatic secretion_Homo sapiens_hsa049723.07765236
8Ribosome_Homo sapiens_hsa030102.46201858
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36955260
10Nitrogen metabolism_Homo sapiens_hsa009102.35920887
11ECM-receptor interaction_Homo sapiens_hsa045122.17207595
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59721501
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56735504
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.55934555
15Vitamin digestion and absorption_Homo sapiens_hsa049771.54136658
16Wnt signaling pathway_Homo sapiens_hsa043101.49418983
17Fat digestion and absorption_Homo sapiens_hsa049751.44644422
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43729779
19Hippo signaling pathway_Homo sapiens_hsa043901.42920956
20Phenylalanine metabolism_Homo sapiens_hsa003601.36046516
21Mineral absorption_Homo sapiens_hsa049781.34882770
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32797076
23Axon guidance_Homo sapiens_hsa043601.31217531
24Propanoate metabolism_Homo sapiens_hsa006401.29627824
25Thyroid cancer_Homo sapiens_hsa052161.26496381
26Colorectal cancer_Homo sapiens_hsa052101.24227485
27Retinol metabolism_Homo sapiens_hsa008301.23724732
28Melanogenesis_Homo sapiens_hsa049161.22303575
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20825543
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19973643
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19499356
32Gastric acid secretion_Homo sapiens_hsa049711.18169425
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17866907
34TGF-beta signaling pathway_Homo sapiens_hsa043501.17536007
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17309357
36Adherens junction_Homo sapiens_hsa045201.12180222
37Fatty acid elongation_Homo sapiens_hsa000621.11069140
38Proteoglycans in cancer_Homo sapiens_hsa052051.08610459
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08159955
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08147317
41Nicotine addiction_Homo sapiens_hsa050331.06250955
42Galactose metabolism_Homo sapiens_hsa000521.03586150
43Folate biosynthesis_Homo sapiens_hsa007901.02845465
44Renin secretion_Homo sapiens_hsa049241.01235909
45beta-Alanine metabolism_Homo sapiens_hsa004100.99879895
46Melanoma_Homo sapiens_hsa052180.99323506
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98185462
48Pathways in cancer_Homo sapiens_hsa052000.97161125
49Amoebiasis_Homo sapiens_hsa051460.97127343
50Fatty acid degradation_Homo sapiens_hsa000710.95961803
51Histidine metabolism_Homo sapiens_hsa003400.95791097
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95602736
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93456095
54Butanoate metabolism_Homo sapiens_hsa006500.92195218
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91000654
56Chemical carcinogenesis_Homo sapiens_hsa052040.89702228
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89114208
58Dilated cardiomyopathy_Homo sapiens_hsa054140.88495876
59Protein export_Homo sapiens_hsa030600.87207892
60Pyruvate metabolism_Homo sapiens_hsa006200.86725193
61Glycerolipid metabolism_Homo sapiens_hsa005610.84888494
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.83315433
63Peroxisome_Homo sapiens_hsa041460.82679300
64Circadian entrainment_Homo sapiens_hsa047130.78184469
65N-Glycan biosynthesis_Homo sapiens_hsa005100.76299095
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75517528
67Renin-angiotensin system_Homo sapiens_hsa046140.75405212
68Tyrosine metabolism_Homo sapiens_hsa003500.75275295
69Prostate cancer_Homo sapiens_hsa052150.74957984
70Prolactin signaling pathway_Homo sapiens_hsa049170.74121709
71Focal adhesion_Homo sapiens_hsa045100.73668360
72Bile secretion_Homo sapiens_hsa049760.73584889
73Dorso-ventral axis formation_Homo sapiens_hsa043200.73231557
74Selenocompound metabolism_Homo sapiens_hsa004500.71594819
75Salivary secretion_Homo sapiens_hsa049700.70611181
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70000012
77One carbon pool by folate_Homo sapiens_hsa006700.69866953
78Notch signaling pathway_Homo sapiens_hsa043300.69243397
79Fatty acid metabolism_Homo sapiens_hsa012120.69075060
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68916676
81Rap1 signaling pathway_Homo sapiens_hsa040150.68796362
82Steroid biosynthesis_Homo sapiens_hsa001000.68133525
83Sphingolipid metabolism_Homo sapiens_hsa006000.67754875
84Basal transcription factors_Homo sapiens_hsa030220.67150170
85cAMP signaling pathway_Homo sapiens_hsa040240.66354871
86Small cell lung cancer_Homo sapiens_hsa052220.65808286
87Pancreatic cancer_Homo sapiens_hsa052120.65247753
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64626817
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64580466
90Parkinsons disease_Homo sapiens_hsa050120.64488198
91Alzheimers disease_Homo sapiens_hsa050100.64142789
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63973017
93Oxidative phosphorylation_Homo sapiens_hsa001900.62360735
94Endometrial cancer_Homo sapiens_hsa052130.62182459
95Lysine degradation_Homo sapiens_hsa003100.61585304
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60817902
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.59144016
98Glutathione metabolism_Homo sapiens_hsa004800.58241693
99Arachidonic acid metabolism_Homo sapiens_hsa005900.57758538
100Linoleic acid metabolism_Homo sapiens_hsa005910.57293374
101Toxoplasmosis_Homo sapiens_hsa051450.56890729
102Morphine addiction_Homo sapiens_hsa050320.56590613
103Sulfur metabolism_Homo sapiens_hsa009200.54705370
104Huntingtons disease_Homo sapiens_hsa050160.54088082
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53982099
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53060376
107Ras signaling pathway_Homo sapiens_hsa040140.52471906
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52387788
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52249993
110Calcium signaling pathway_Homo sapiens_hsa040200.52149566
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51964357
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50678957
113Tryptophan metabolism_Homo sapiens_hsa003800.50100924
114MicroRNAs in cancer_Homo sapiens_hsa052060.50025325
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49689871
116Glutamatergic synapse_Homo sapiens_hsa047240.49254931
117Oocyte meiosis_Homo sapiens_hsa041140.48041060
118Renal cell carcinoma_Homo sapiens_hsa052110.47982877
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47683769
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47248248
121Long-term depression_Homo sapiens_hsa047300.46140973
122Collecting duct acid secretion_Homo sapiens_hsa049660.45470968
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44682002
124ErbB signaling pathway_Homo sapiens_hsa040120.43857450
125Olfactory transduction_Homo sapiens_hsa047400.42533935
126Tight junction_Homo sapiens_hsa045300.42144138
127Phototransduction_Homo sapiens_hsa047440.42082664
128Taste transduction_Homo sapiens_hsa047420.41244933
129GABAergic synapse_Homo sapiens_hsa047270.40764534
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39793913
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39389798
132Bladder cancer_Homo sapiens_hsa052190.39141098
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38030251
134Serotonergic synapse_Homo sapiens_hsa047260.37886840
135Estrogen signaling pathway_Homo sapiens_hsa049150.37664849
136Starch and sucrose metabolism_Homo sapiens_hsa005000.36700869
137Viral myocarditis_Homo sapiens_hsa054160.36432084
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35752737
139Ovarian steroidogenesis_Homo sapiens_hsa049130.35503411
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35134235
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34882538
142Long-term potentiation_Homo sapiens_hsa047200.33726705
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33066136
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32685082
145Ether lipid metabolism_Homo sapiens_hsa005650.32449709
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31887467
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30932338

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