

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.04553940 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.97286048 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.69838655 |
| 4 | vocalization behavior (GO:0071625) | 5.48126712 |
| 5 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.46312511 |
| 6 | synaptic vesicle maturation (GO:0016188) | 5.46139074 |
| 7 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.39971329 |
| 8 | angiotensin maturation (GO:0002003) | 5.26438011 |
| 9 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.16166238 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.08874863 |
| 11 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 5.07262734 |
| 12 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.97211397 |
| 13 | synaptic vesicle exocytosis (GO:0016079) | 4.81171042 |
| 14 | regulation of synapse structural plasticity (GO:0051823) | 4.76182680 |
| 15 | exploration behavior (GO:0035640) | 4.68826670 |
| 16 | glutamate receptor signaling pathway (GO:0007215) | 4.67226823 |
| 17 | protein localization to synapse (GO:0035418) | 4.61360931 |
| 18 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.54085290 |
| 19 | neuronal action potential propagation (GO:0019227) | 4.53165587 |
| 20 | synaptic transmission, glutamatergic (GO:0035249) | 4.53109228 |
| 21 | glutamate secretion (GO:0014047) | 4.51487060 |
| 22 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.48033474 |
| 23 | regulation of guanylate cyclase activity (GO:0031282) | 4.46841924 |
| 24 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 4.39377124 |
| 25 | neuron-neuron synaptic transmission (GO:0007270) | 4.37361987 |
| 26 | dendritic spine morphogenesis (GO:0060997) | 4.33234692 |
| 27 | long-term memory (GO:0007616) | 4.30647303 |
| 28 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.28271356 |
| 29 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.25713194 |
| 30 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.22934062 |
| 31 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.22817631 |
| 32 | neuron cell-cell adhesion (GO:0007158) | 4.17195892 |
| 33 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.15289545 |
| 34 | regulation of synaptic vesicle transport (GO:1902803) | 4.08715290 |
| 35 | NADH metabolic process (GO:0006734) | 4.06372938 |
| 36 | regulation of synaptic plasticity (GO:0048167) | 4.06108023 |
| 37 | positive regulation of membrane potential (GO:0045838) | 4.04885441 |
| 38 | proline transport (GO:0015824) | 4.01641550 |
| 39 | neurotransmitter secretion (GO:0007269) | 3.96119073 |
| 40 | regulation of postsynaptic membrane potential (GO:0060078) | 3.93488861 |
| 41 | long-term synaptic potentiation (GO:0060291) | 3.92510842 |
| 42 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.92267376 |
| 43 | prepulse inhibition (GO:0060134) | 3.90974016 |
| 44 | synaptic transmission, dopaminergic (GO:0001963) | 3.84821563 |
| 45 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.83888544 |
| 46 | neuromuscular process controlling balance (GO:0050885) | 3.74356260 |
| 47 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.74341615 |
| 48 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.71492043 |
| 49 | behavioral fear response (GO:0001662) | 3.67894305 |
| 50 | behavioral defense response (GO:0002209) | 3.67894305 |
| 51 | auditory behavior (GO:0031223) | 3.67530835 |
| 52 | potassium ion homeostasis (GO:0055075) | 3.67031040 |
| 53 | lipoprotein transport (GO:0042953) | 3.66768104 |
| 54 | transmission of nerve impulse (GO:0019226) | 3.66605477 |
| 55 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.65999483 |
| 56 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.64916493 |
| 57 | positive regulation of neurotransmitter transport (GO:0051590) | 3.64782544 |
| 58 | regulation of female receptivity (GO:0045924) | 3.64274823 |
| 59 | positive regulation of guanylate cyclase activity (GO:0031284) | 3.62736620 |
| 60 | layer formation in cerebral cortex (GO:0021819) | 3.61000749 |
| 61 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.60595087 |
| 62 | cellular potassium ion homeostasis (GO:0030007) | 3.60281302 |
| 63 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.57846544 |
| 64 | amino acid import (GO:0043090) | 3.57514979 |
| 65 | positive regulation of synapse maturation (GO:0090129) | 3.56739513 |
| 66 | dendritic spine organization (GO:0097061) | 3.56383126 |
| 67 | potassium ion import (GO:0010107) | 3.55178024 |
| 68 | behavioral response to cocaine (GO:0048148) | 3.53780723 |
| 69 | regulation of dendritic spine development (GO:0060998) | 3.47992272 |
| 70 | cellular sodium ion homeostasis (GO:0006883) | 3.47009505 |
| 71 | gamma-aminobutyric acid transport (GO:0015812) | 3.45844661 |
| 72 | regulation of bile acid biosynthetic process (GO:0070857) | 3.44935275 |
| 73 | regulation of ARF protein signal transduction (GO:0032012) | 3.44773254 |
| 74 | response to amphetamine (GO:0001975) | 3.44732647 |
| 75 | regulation of glutamate secretion (GO:0014048) | 3.42866358 |
| 76 | response to histamine (GO:0034776) | 3.41649606 |
| 77 | striatum development (GO:0021756) | 3.38596936 |
| 78 | fear response (GO:0042596) | 3.38256684 |
| 79 | neuron recognition (GO:0008038) | 3.36992081 |
| 80 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.36406825 |
| 81 | positive regulation of dendritic spine development (GO:0060999) | 3.35669939 |
| 82 | response to auditory stimulus (GO:0010996) | 3.34591474 |
| 83 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.33873984 |
| 84 | female mating behavior (GO:0060180) | 3.32759067 |
| 85 | activation of protein kinase A activity (GO:0034199) | 3.31998653 |
| 86 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.31962617 |
| 87 | epoxygenase P450 pathway (GO:0019373) | 3.31376868 |
| 88 | learning (GO:0007612) | 3.30665895 |
| 89 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.29574149 |
| 90 | membrane depolarization (GO:0051899) | 3.28599852 |
| 91 | neuronal ion channel clustering (GO:0045161) | 3.27504902 |
| 92 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.24511846 |
| 93 | neurotransmitter transport (GO:0006836) | 3.24140644 |
| 94 | long term synaptic depression (GO:0060292) | 3.20689138 |
| 95 | synaptic vesicle endocytosis (GO:0048488) | 3.19311611 |
| 96 | axon ensheathment in central nervous system (GO:0032291) | 3.19236212 |
| 97 | central nervous system myelination (GO:0022010) | 3.19236212 |
| 98 | regulation of neurotransmitter secretion (GO:0046928) | 3.18294282 |
| 99 | positive regulation of synaptic transmission (GO:0050806) | 3.17832581 |
| 100 | sodium ion export (GO:0071436) | 3.16378561 |
| 101 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.15303798 |
| 102 | dopamine receptor signaling pathway (GO:0007212) | 3.15262280 |
| 103 | regulation of vesicle fusion (GO:0031338) | 3.12684755 |
| 104 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.12321546 |
| 105 | membrane hyperpolarization (GO:0060081) | 3.12297468 |
| 106 | peptide hormone processing (GO:0016486) | 3.12270260 |
| 107 | L-amino acid import (GO:0043092) | 3.12057851 |
| 108 | regulation of synaptic transmission (GO:0050804) | 3.10203652 |
| 109 | chemosensory behavior (GO:0007635) | 3.09414271 |
| 110 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.09152852 |
| 111 | regulation of neurotransmitter transport (GO:0051588) | 3.08993160 |
| 112 | cell communication by electrical coupling (GO:0010644) | 3.08326632 |
| 113 | regulation of neurotransmitter levels (GO:0001505) | 3.07705282 |
| 114 | cerebellar granule cell differentiation (GO:0021707) | 3.06149148 |
| 115 | axonal fasciculation (GO:0007413) | 3.05415420 |
| 116 | fructose metabolic process (GO:0006000) | 3.02545465 |
| 117 | neuromuscular process (GO:0050905) | 3.02423749 |
| 118 | visual learning (GO:0008542) | 3.01144741 |
| 119 | vesicle transport along microtubule (GO:0047496) | 3.00910823 |
| 120 | glycine transport (GO:0015816) | 3.00863756 |
| 121 | regulation of neurotransmitter uptake (GO:0051580) | 2.98451037 |
| 122 | membrane depolarization during action potential (GO:0086010) | 2.97761340 |
| 123 | regulation of synapse maturation (GO:0090128) | 2.91280109 |
| 124 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.91224486 |
| 125 | cell communication involved in cardiac conduction (GO:0086065) | 2.89810448 |
| 126 | acidic amino acid transport (GO:0015800) | 2.89677831 |
| 127 | intestinal absorption (GO:0050892) | 2.87092157 |
| 128 | cellular response to nitric oxide (GO:0071732) | 2.86495121 |
| 129 | sodium ion homeostasis (GO:0055078) | 2.85168464 |
| 130 | regulation of cGMP biosynthetic process (GO:0030826) | 2.84254215 |
| 131 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.83658223 |
| 132 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 2.82014132 |
| 133 | endocrine process (GO:0050886) | 2.82014132 |
| 134 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 2.82014132 |
| 135 | phosphate ion transmembrane transport (GO:0035435) | 2.75912719 |
| 136 | serotonin metabolic process (GO:0042428) | 2.75868501 |
| 137 | signal release (GO:0023061) | 2.75735919 |
| 138 | detection of calcium ion (GO:0005513) | 2.71646386 |
| 139 | drinking behavior (GO:0042756) | 2.65983790 |
| 140 | cGMP-mediated signaling (GO:0019934) | 2.65863502 |
| 141 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 2.64894687 |
| 142 | diacylglycerol metabolic process (GO:0046339) | 2.64153911 |
| 143 | L-glutamate transport (GO:0015813) | 2.63970362 |
| 144 | myelin maintenance (GO:0043217) | 2.62783732 |
| 145 | regulation of systemic arterial blood pressure (GO:0003073) | 2.62692702 |
| 146 | dicarboxylic acid transport (GO:0006835) | 2.60712023 |
| 147 | neuromuscular process controlling posture (GO:0050884) | 2.58361150 |
| 148 | fat-soluble vitamin biosynthetic process (GO:0042362) | 2.57586201 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.20705010 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.50874990 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.26452906 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.26218626 |
| 5 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.24531116 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.17098826 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.81942590 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.81942590 |
| 9 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.76894183 |
| 10 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.76865187 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.75855972 |
| 12 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.68437247 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.62335345 |
| 14 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.60385093 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.58786497 |
| 16 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.55407134 |
| 17 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.52502355 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.50275266 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.34526703 |
| 20 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.32941620 |
| 21 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 2.28775726 |
| 22 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.28608033 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.28240470 |
| 24 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.28052322 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.24837292 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.23706561 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.99471322 |
| 28 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.89054263 |
| 29 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.87776822 |
| 30 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.84838351 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.71523212 |
| 32 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.70626973 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.65400970 |
| 34 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.61895492 |
| 35 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.59690527 |
| 36 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.57751806 |
| 37 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.57222233 |
| 38 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.56589124 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.52747723 |
| 40 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.50055258 |
| 41 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.49881097 |
| 42 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.44653272 |
| 43 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.37135403 |
| 44 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.36137849 |
| 45 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.34320252 |
| 46 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.32659986 |
| 47 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32465660 |
| 48 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.31991949 |
| 49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.31216872 |
| 50 | P300_19829295_ChIP-Seq_ESCs_Human | 1.30707617 |
| 51 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.30417766 |
| 52 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.30265638 |
| 53 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.29444912 |
| 54 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.28516350 |
| 55 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.28509010 |
| 56 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.27789148 |
| 57 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.27384323 |
| 58 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.27372283 |
| 59 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.26446632 |
| 60 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.22930730 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.22370776 |
| 62 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.20644110 |
| 63 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20535284 |
| 64 | STAT3_23295773_ChIP-Seq_U87_Human | 1.18258457 |
| 65 | AR_19668381_ChIP-Seq_PC3_Human | 1.17893565 |
| 66 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.17147076 |
| 67 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.16330928 |
| 68 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.16083647 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.15420046 |
| 70 | KDM2B_26808549_Chip-Seq_K562_Human | 1.15275881 |
| 71 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12314681 |
| 72 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.11658859 |
| 73 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.11322468 |
| 74 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.09651107 |
| 75 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.09534961 |
| 76 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.09241164 |
| 77 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.09221771 |
| 78 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09208940 |
| 79 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.08857224 |
| 80 | TP53_16413492_ChIP-PET_HCT116_Human | 1.08376376 |
| 81 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08179802 |
| 82 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07497937 |
| 83 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.06458715 |
| 84 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.06297366 |
| 85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.05342392 |
| 86 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.05153329 |
| 87 | TCF4_23295773_ChIP-Seq_U87_Human | 1.04047045 |
| 88 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.04003544 |
| 89 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.03741849 |
| 90 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.03282427 |
| 91 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.02780958 |
| 92 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.02259961 |
| 93 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.01906308 |
| 94 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.00649684 |
| 95 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.99991024 |
| 96 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.99975985 |
| 97 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.98559733 |
| 98 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.98119400 |
| 99 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.97757336 |
| 100 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.97363399 |
| 101 | SA1_27219007_Chip-Seq_Bcells_Human | 0.96192089 |
| 102 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.95793053 |
| 103 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.94676738 |
| 104 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.94479873 |
| 105 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.93926235 |
| 106 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.93289625 |
| 107 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92238497 |
| 108 | RXR_22108803_ChIP-Seq_LS180_Human | 0.92065423 |
| 109 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.91675767 |
| 110 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.91312163 |
| 111 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.91055892 |
| 112 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.89688250 |
| 113 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.89121894 |
| 114 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.88849941 |
| 115 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.88836969 |
| 116 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.88635347 |
| 117 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.88540556 |
| 118 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88463771 |
| 119 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.87917511 |
| 120 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.87895111 |
| 121 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.87634419 |
| 122 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.87613012 |
| 123 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.87407687 |
| 124 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87029135 |
| 125 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.86647780 |
| 126 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.86366894 |
| 127 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.85466673 |
| 128 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.85259869 |
| 129 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.84084193 |
| 130 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.83997581 |
| 131 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.83861034 |
| 132 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.83516351 |
| 133 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.83373827 |
| 134 | JUN_21703547_ChIP-Seq_K562_Human | 0.83294071 |
| 135 | FUS_26573619_Chip-Seq_HEK293_Human | 0.82856058 |
| 136 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.82606103 |
| 137 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.82528746 |
| 138 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.82317187 |
| 139 | SOX3_22085726_ChIP-Seq_MUSCLE_Mouse | 0.82098967 |
| 140 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.81567170 |
| 141 | P68_20966046_ChIP-Seq_HELA_Human | 0.80366269 |
| 142 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.79607836 |
| 143 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.79353187 |
| 144 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.78451752 |
| 145 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.78179427 |
| 146 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.77149952 |
| 147 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.76608791 |
| 148 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.76407599 |
| 149 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.74975487 |
| 150 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.74291074 |
| 151 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.73888395 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.38473680 |
| 2 | MP0003880_abnormal_central_pattern | 5.11915190 |
| 3 | MP0002822_catalepsy | 4.88909157 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 4.37749972 |
| 5 | MP0005360_urolithiasis | 3.97660477 |
| 6 | MP0004270_analgesia | 3.75390329 |
| 7 | MP0009745_abnormal_behavioral_response | 3.73072253 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.62260423 |
| 9 | MP0002064_seizures | 3.24539637 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.93572276 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.88810451 |
| 12 | MP0009046_muscle_twitch | 2.72257503 |
| 13 | MP0001486_abnormal_startle_reflex | 2.71130397 |
| 14 | MP0002272_abnormal_nervous_system | 2.70907038 |
| 15 | MP0003183_abnormal_peptide_metabolism | 2.69689184 |
| 16 | MP0001666_abnormal_nutrient_absorption | 2.54140389 |
| 17 | MP0005423_abnormal_somatic_nervous | 2.42373663 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.36166683 |
| 19 | MP0002139_abnormal_hepatobiliary_system | 2.34273995 |
| 20 | MP0002734_abnormal_mechanical_nocicepti | 2.33635290 |
| 21 | MP0002736_abnormal_nociception_after | 2.26828294 |
| 22 | MP0005085_abnormal_gallbladder_physiolo | 2.20120178 |
| 23 | MP0004019_abnormal_vitamin_homeostasis | 2.18475957 |
| 24 | MP0001440_abnormal_grooming_behavior | 2.05879888 |
| 25 | MP0002735_abnormal_chemical_nociception | 1.99854201 |
| 26 | MP0001529_abnormal_vocalization | 1.99542138 |
| 27 | MP0005365_abnormal_bile_salt | 1.90412779 |
| 28 | MP0009780_abnormal_chondrocyte_physiolo | 1.88025628 |
| 29 | MP0005646_abnormal_pituitary_gland | 1.85591623 |
| 30 | MP0001970_abnormal_pain_threshold | 1.84085980 |
| 31 | MP0008569_lethality_at_weaning | 1.83407738 |
| 32 | MP0003329_amyloid_beta_deposits | 1.82168659 |
| 33 | MP0002909_abnormal_adrenal_gland | 1.81178086 |
| 34 | MP0002067_abnormal_sensory_capabilities | 1.79923188 |
| 35 | MP0002733_abnormal_thermal_nociception | 1.79002555 |
| 36 | MP0004811_abnormal_neuron_physiology | 1.70522732 |
| 37 | MP0002557_abnormal_social/conspecific_i | 1.68454217 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.68342612 |
| 39 | MP0004924_abnormal_behavior | 1.68342612 |
| 40 | MP0003879_abnormal_hair_cell | 1.67353062 |
| 41 | MP0001984_abnormal_olfaction | 1.67084831 |
| 42 | MP0009379_abnormal_foot_pigmentation | 1.55946542 |
| 43 | MP0002184_abnormal_innervation | 1.54627348 |
| 44 | MP0000778_abnormal_nervous_system | 1.52240969 |
| 45 | MP0010329_abnormal_lipoprotein_level | 1.49197995 |
| 46 | MP0004885_abnormal_endolymph | 1.45950797 |
| 47 | MP0004264_abnormal_extraembryonic_tissu | 1.40634930 |
| 48 | MP0003633_abnormal_nervous_system | 1.40429474 |
| 49 | MP0002066_abnormal_motor_capabilities/c | 1.39894113 |
| 50 | MP0009840_abnormal_foam_cell | 1.39410868 |
| 51 | MP0004858_abnormal_nervous_system | 1.38524343 |
| 52 | MP0000955_abnormal_spinal_cord | 1.38240754 |
| 53 | MP0001905_abnormal_dopamine_level | 1.35015392 |
| 54 | MP0001188_hyperpigmentation | 1.34063206 |
| 55 | MP0003075_altered_response_to | 1.33409849 |
| 56 | MP0003787_abnormal_imprinting | 1.32791794 |
| 57 | MP0002882_abnormal_neuron_morphology | 1.32489084 |
| 58 | MP0005332_abnormal_amino_acid | 1.31422305 |
| 59 | MP0005409_darkened_coat_color | 1.31145983 |
| 60 | MP0003123_paternal_imprinting | 1.28537703 |
| 61 | MP0008872_abnormal_physiological_respon | 1.23359720 |
| 62 | MP0005645_abnormal_hypothalamus_physiol | 1.20584596 |
| 63 | MP0003631_nervous_system_phenotype | 1.18647713 |
| 64 | MP0001502_abnormal_circadian_rhythm | 1.11290420 |
| 65 | MP0006276_abnormal_autonomic_nervous | 1.10795625 |
| 66 | MP0008874_decreased_physiological_sensi | 1.07497360 |
| 67 | MP0002152_abnormal_brain_morphology | 1.04705723 |
| 68 | MP0003868_abnormal_feces_composition | 1.01964699 |
| 69 | MP0004142_abnormal_muscle_tone | 1.01494478 |
| 70 | MP0001756_abnormal_urination | 1.00650053 |
| 71 | MP0005636_abnormal_mineral_homeostasis | 1.00279157 |
| 72 | MP0001346_abnormal_lacrimal_gland | 0.98344773 |
| 73 | MP0000920_abnormal_myelination | 0.97706795 |
| 74 | MP0002069_abnormal_eating/drinking_beha | 0.95165506 |
| 75 | MP0003866_abnormal_defecation | 0.94842302 |
| 76 | MP0005448_abnormal_energy_balance | 0.94460390 |
| 77 | MP0009643_abnormal_urine_homeostasis | 0.91709318 |
| 78 | MP0001177_atelectasis | 0.91399845 |
| 79 | MP0005535_abnormal_body_temperature | 0.90700447 |
| 80 | MP0004742_abnormal_vestibular_system | 0.90365102 |
| 81 | MP0002229_neurodegeneration | 0.90006076 |
| 82 | MP0005167_abnormal_blood-brain_barrier | 0.89674669 |
| 83 | MP0003690_abnormal_glial_cell | 0.89452021 |
| 84 | MP0004085_abnormal_heartbeat | 0.89445658 |
| 85 | MP0000678_abnormal_parathyroid_gland | 0.86616359 |
| 86 | MP0002118_abnormal_lipid_homeostasis | 0.86278546 |
| 87 | MP0000462_abnormal_digestive_system | 0.84755564 |
| 88 | MP0005499_abnormal_olfactory_system | 0.83910013 |
| 89 | MP0005394_taste/olfaction_phenotype | 0.83910013 |
| 90 | MP0001485_abnormal_pinna_reflex | 0.83200745 |
| 91 | MP0010234_abnormal_vibrissa_follicle | 0.83121061 |
| 92 | MP0000604_amyloidosis | 0.81439535 |
| 93 | MP0000013_abnormal_adipose_tissue | 0.80941635 |
| 94 | MP0005551_abnormal_eye_electrophysiolog | 0.78029515 |
| 95 | MP0001963_abnormal_hearing_physiology | 0.77378586 |
| 96 | MP0003632_abnormal_nervous_system | 0.76930130 |
| 97 | MP0003656_abnormal_erythrocyte_physiolo | 0.76698677 |
| 98 | MP0003634_abnormal_glial_cell | 0.75254233 |
| 99 | MP0004147_increased_porphyrin_level | 0.75056861 |
| 100 | MP0004145_abnormal_muscle_electrophysio | 0.73778953 |
| 101 | MP0002078_abnormal_glucose_homeostasis | 0.71917672 |
| 102 | MP0000538_abnormal_urinary_bladder | 0.69355868 |
| 103 | MP0001664_abnormal_digestion | 0.68892654 |
| 104 | MP0004043_abnormal_pH_regulation | 0.68354693 |
| 105 | MP0002638_abnormal_pupillary_reflex | 0.67967208 |
| 106 | MP0010155_abnormal_intestine_physiology | 0.67821412 |
| 107 | MP0008961_abnormal_basal_metabolism | 0.66820902 |
| 108 | MP0000631_abnormal_neuroendocrine_gland | 0.66517682 |
| 109 | MP0010386_abnormal_urinary_bladder | 0.65739257 |
| 110 | MP0003953_abnormal_hormone_level | 0.65670185 |
| 111 | MP0002090_abnormal_vision | 0.64670579 |
| 112 | MP0004484_altered_response_of | 0.64442538 |
| 113 | MP0004510_myositis | 0.63444328 |
| 114 | MP0000751_myopathy | 0.63386000 |
| 115 | MP0000681_abnormal_thyroid_gland | 0.62344809 |
| 116 | MP0004215_abnormal_myocardial_fiber | 0.61317020 |
| 117 | MP0002752_abnormal_somatic_nervous | 0.61074385 |
| 118 | MP0001765_abnormal_ion_homeostasis | 0.59105696 |
| 119 | MP0000230_abnormal_systemic_arterial | 0.58951247 |
| 120 | MP0002837_dystrophic_cardiac_calcinosis | 0.57187293 |
| 121 | MP0003283_abnormal_digestive_organ | 0.54991281 |
| 122 | MP0003137_abnormal_impulse_conducting | 0.54235864 |
| 123 | MP0005166_decreased_susceptibility_to | 0.52910583 |
| 124 | MP0002876_abnormal_thyroid_physiology | 0.48114971 |
| 125 | MP0003956_abnormal_body_size | 0.47928658 |
| 126 | MP0003122_maternal_imprinting | 0.46544062 |
| 127 | MP0010769_abnormal_survival | 0.45541824 |
| 128 | MP0001943_abnormal_respiration | 0.45095743 |
| 129 | MP0005171_absent_coat_pigmentation | 0.45009278 |
| 130 | MP0003172_abnormal_lysosome_physiology | 0.44307983 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.68345002 |
| 2 | Myokymia (HP:0002411) | 7.97037158 |
| 3 | Focal seizures (HP:0007359) | 6.20017203 |
| 4 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 6.00436707 |
| 5 | Visual hallucinations (HP:0002367) | 5.21564879 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.77447668 |
| 7 | Abnormality of proline metabolism (HP:0010907) | 4.63720740 |
| 8 | Hydroxyprolinuria (HP:0003080) | 4.63720740 |
| 9 | Atonic seizures (HP:0010819) | 4.34266611 |
| 10 | Febrile seizures (HP:0002373) | 4.25045445 |
| 11 | Absence seizures (HP:0002121) | 4.20902282 |
| 12 | Action tremor (HP:0002345) | 4.09876938 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 4.06646620 |
| 14 | Dialeptic seizures (HP:0011146) | 4.03857796 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.85521210 |
| 16 | Broad-based gait (HP:0002136) | 3.80997894 |
| 17 | Poor eye contact (HP:0000817) | 3.73294272 |
| 18 | Anxiety (HP:0000739) | 3.66766715 |
| 19 | Malnutrition (HP:0004395) | 3.63962156 |
| 20 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.63740752 |
| 21 | Hyperventilation (HP:0002883) | 3.63134753 |
| 22 | Confusion (HP:0001289) | 3.60911422 |
| 23 | Depression (HP:0000716) | 3.57419554 |
| 24 | Gaze-evoked nystagmus (HP:0000640) | 3.54035327 |
| 25 | Dysmetria (HP:0001310) | 3.49626005 |
| 26 | Dysdiadochokinesis (HP:0002075) | 3.48076025 |
| 27 | Impaired social interactions (HP:0000735) | 3.37071464 |
| 28 | Abnormal social behavior (HP:0012433) | 3.37071464 |
| 29 | Ankle clonus (HP:0011448) | 3.30984027 |
| 30 | Amblyopia (HP:0000646) | 3.29314608 |
| 31 | Supranuclear gaze palsy (HP:0000605) | 3.29261485 |
| 32 | Limb dystonia (HP:0002451) | 3.25604136 |
| 33 | Truncal ataxia (HP:0002078) | 3.23527769 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.09568452 |
| 35 | Postural instability (HP:0002172) | 3.08142462 |
| 36 | Increased circulating renin level (HP:0000848) | 3.07531610 |
| 37 | Annular pancreas (HP:0001734) | 3.07307494 |
| 38 | Torticollis (HP:0000473) | 3.05730175 |
| 39 | Hypobetalipoproteinemia (HP:0003563) | 3.01140379 |
| 40 | Akinesia (HP:0002304) | 2.97149615 |
| 41 | Cerebral inclusion bodies (HP:0100314) | 2.96464179 |
| 42 | Widely patent fontanelles and sutures (HP:0004492) | 2.94377256 |
| 43 | Abnormality of vitamin B metabolism (HP:0004340) | 2.90824044 |
| 44 | Metabolic alkalosis (HP:0200114) | 2.88941027 |
| 45 | Hyperparathyroidism (HP:0000843) | 2.84448048 |
| 46 | Papilledema (HP:0001085) | 2.83701812 |
| 47 | Focal dystonia (HP:0004373) | 2.83030153 |
| 48 | Neurofibrillary tangles (HP:0002185) | 2.82524276 |
| 49 | Impaired smooth pursuit (HP:0007772) | 2.81801018 |
| 50 | Scanning speech (HP:0002168) | 2.80771927 |
| 51 | Intention tremor (HP:0002080) | 2.79758905 |
| 52 | Stereotypic behavior (HP:0000733) | 2.78060876 |
| 53 | Pigmentary retinal degeneration (HP:0001146) | 2.73697088 |
| 54 | Urinary urgency (HP:0000012) | 2.72488390 |
| 55 | Abnormality of the lower motor neuron (HP:0002366) | 2.69471218 |
| 56 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.68905972 |
| 57 | Excessive salivation (HP:0003781) | 2.64989939 |
| 58 | Drooling (HP:0002307) | 2.64989939 |
| 59 | Hemiparesis (HP:0001269) | 2.63136836 |
| 60 | Fat malabsorption (HP:0002630) | 2.62483120 |
| 61 | Abnormality of vitamin metabolism (HP:0100508) | 2.61906001 |
| 62 | Absent speech (HP:0001344) | 2.61133005 |
| 63 | Abnormal eating behavior (HP:0100738) | 2.59012387 |
| 64 | Spastic gait (HP:0002064) | 2.56650864 |
| 65 | Tetraplegia (HP:0002445) | 2.54471704 |
| 66 | Impaired vibratory sensation (HP:0002495) | 2.52705758 |
| 67 | Craniofacial dystonia (HP:0012179) | 2.51934311 |
| 68 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.51700204 |
| 69 | Mutism (HP:0002300) | 2.51678790 |
| 70 | Abnormality of renin-angiotensin system (HP:0000847) | 2.51092172 |
| 71 | Bradykinesia (HP:0002067) | 2.50244811 |
| 72 | Megalencephaly (HP:0001355) | 2.47734841 |
| 73 | Resting tremor (HP:0002322) | 2.47609340 |
| 74 | Dysmetric saccades (HP:0000641) | 2.43934956 |
| 75 | Insomnia (HP:0100785) | 2.41248738 |
| 76 | Abnormality of magnesium homeostasis (HP:0004921) | 2.39770465 |
| 77 | Epileptiform EEG discharges (HP:0011182) | 2.39346821 |
| 78 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.37465913 |
| 79 | Progressive inability to walk (HP:0002505) | 2.37078217 |
| 80 | Ankyloglossia (HP:0010296) | 2.36378460 |
| 81 | Delusions (HP:0000746) | 2.36225330 |
| 82 | Termporal pattern (HP:0011008) | 2.36115607 |
| 83 | Insidious onset (HP:0003587) | 2.36115607 |
| 84 | Status epilepticus (HP:0002133) | 2.32157272 |
| 85 | Diplopia (HP:0000651) | 2.31417910 |
| 86 | Abnormality of binocular vision (HP:0011514) | 2.31417910 |
| 87 | Hyperglycinuria (HP:0003108) | 2.30973993 |
| 88 | Genetic anticipation (HP:0003743) | 2.28768535 |
| 89 | Ventricular fibrillation (HP:0001663) | 2.26429422 |
| 90 | Hypotension (HP:0002615) | 2.25850189 |
| 91 | Hyperphosphatemia (HP:0002905) | 2.24335208 |
| 92 | Pointed chin (HP:0000307) | 2.24258126 |
| 93 | Ileus (HP:0002595) | 2.21353583 |
| 94 | EEG with generalized epileptiform discharges (HP:0011198) | 2.21262249 |
| 95 | Hyperactive renin-angiotensin system (HP:0000841) | 2.20327374 |
| 96 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.20310682 |
| 97 | Incomplete penetrance (HP:0003829) | 2.20139815 |
| 98 | Acanthocytosis (HP:0001927) | 2.20134505 |
| 99 | Hemiplegia (HP:0002301) | 2.18276484 |
| 100 | Generalized myoclonic seizures (HP:0002123) | 2.16764185 |
| 101 | Growth hormone excess (HP:0000845) | 2.16532460 |
| 102 | Abnormality of urine glucose concentration (HP:0011016) | 2.16019106 |
| 103 | Glycosuria (HP:0003076) | 2.16019106 |
| 104 | Syncope (HP:0001279) | 2.13755912 |
| 105 | Lower limb muscle weakness (HP:0007340) | 2.12222547 |
| 106 | Irritability (HP:0000737) | 2.11704597 |
| 107 | Thickened helices (HP:0000391) | 2.11275800 |
| 108 | Hypophosphatemia (HP:0002148) | 2.10914014 |
| 109 | Hyperphosphaturia (HP:0003109) | 2.09985639 |
| 110 | Alkalosis (HP:0001948) | 2.09423142 |
| 111 | Lower limb amyotrophy (HP:0007210) | 2.08359575 |
| 112 | Proximal tubulopathy (HP:0000114) | 2.07848469 |
| 113 | Chronic diarrhea (HP:0002028) | 2.07127626 |
| 114 | Hypsarrhythmia (HP:0002521) | 2.06990527 |
| 115 | Nephrolithiasis (HP:0000787) | 2.05754106 |
| 116 | Fetal akinesia sequence (HP:0001989) | 2.05442643 |
| 117 | Polyphagia (HP:0002591) | 2.05413948 |
| 118 | Obstructive sleep apnea (HP:0002870) | 2.04949741 |
| 119 | Decreased circulating renin level (HP:0003351) | 2.04073565 |
| 120 | Potter facies (HP:0002009) | 2.03814750 |
| 121 | Facial shape deformation (HP:0011334) | 2.03814750 |
| 122 | Gait ataxia (HP:0002066) | 2.03676014 |
| 123 | Abnormality of the corticospinal tract (HP:0002492) | 2.01506109 |
| 124 | Abnormal urine phosphate concentration (HP:0012599) | 1.99178611 |
| 125 | Psychosis (HP:0000709) | 1.98651250 |
| 126 | Lower limb asymmetry (HP:0100559) | 1.97788768 |
| 127 | Inability to walk (HP:0002540) | 1.97452701 |
| 128 | Dementia (HP:0000726) | 1.96073499 |
| 129 | Abnormal EKG (HP:0003115) | 1.95853783 |
| 130 | Cerebral hypomyelination (HP:0006808) | 1.94496921 |
| 131 | Gout (HP:0001997) | 1.91235520 |
| 132 | Abnormality of glycine metabolism (HP:0010895) | 1.90573637 |
| 133 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.90573637 |
| 134 | Xanthomatosis (HP:0000991) | 1.90424332 |
| 135 | Blue irides (HP:0000635) | 1.90397017 |
| 136 | Systemic lupus erythematosus (HP:0002725) | 1.88711443 |
| 137 | Bundle branch block (HP:0011710) | 1.86137361 |
| 138 | Postural tremor (HP:0002174) | 1.85410713 |
| 139 | Deep palmar crease (HP:0006191) | 1.83489855 |
| 140 | Abnormality of saccadic eye movements (HP:0000570) | 1.83311756 |
| 141 | Abnormality of salivation (HP:0100755) | 1.83086333 |
| 142 | Bowel incontinence (HP:0002607) | 1.82432681 |
| 143 | Clumsiness (HP:0002312) | 1.81753485 |
| 144 | Protruding tongue (HP:0010808) | 1.80625658 |
| 145 | Neuronal loss in central nervous system (HP:0002529) | 1.79914353 |
| 146 | Abnormality of the periventricular white matter (HP:0002518) | 1.79649188 |
| 147 | Rigidity (HP:0002063) | 1.79393351 |
| 148 | Clonus (HP:0002169) | 1.77330165 |
| 149 | Truncus arteriosus (HP:0001660) | 1.77168018 |
| 150 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.74764973 |
| 151 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.74764973 |
| 152 | Prolonged QT interval (HP:0001657) | 1.72399543 |
| 153 | Poikilocytosis (HP:0004447) | 1.71889164 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 6.56253837 |
| 2 | NTRK3 | 4.80559545 |
| 3 | MAP3K9 | 3.50255847 |
| 4 | RIPK4 | 2.92033106 |
| 5 | RIPK1 | 2.77599476 |
| 6 | DAPK2 | 2.67259107 |
| 7 | KSR2 | 2.63989648 |
| 8 | MINK1 | 2.43219497 |
| 9 | PRKD3 | 2.33854686 |
| 10 | MAP3K4 | 2.33438206 |
| 11 | ACVR1B | 2.29388542 |
| 12 | ARAF | 2.09897052 |
| 13 | PAK6 | 1.93138814 |
| 14 | MAP2K7 | 1.91020107 |
| 15 | MAP3K13 | 1.88824334 |
| 16 | CAMKK1 | 1.86155625 |
| 17 | KSR1 | 1.82530143 |
| 18 | PRKG2 | 1.80391500 |
| 19 | DAPK1 | 1.75042372 |
| 20 | NTRK1 | 1.72173190 |
| 21 | FES | 1.67643559 |
| 22 | MARK1 | 1.66767728 |
| 23 | CDK5 | 1.61458463 |
| 24 | NTRK2 | 1.57768009 |
| 25 | PRPF4B | 1.55966955 |
| 26 | TNIK | 1.50647499 |
| 27 | MAP3K12 | 1.47146781 |
| 28 | MAP2K4 | 1.46455238 |
| 29 | MAP3K2 | 1.40153953 |
| 30 | RAF1 | 1.39748133 |
| 31 | SIK2 | 1.39195655 |
| 32 | GRK5 | 1.35089951 |
| 33 | CASK | 1.34484907 |
| 34 | PLK2 | 1.29513171 |
| 35 | BMPR2 | 1.26750006 |
| 36 | PTK2B | 1.25725661 |
| 37 | STK38 | 1.18020068 |
| 38 | PRKCG | 1.16412530 |
| 39 | TYRO3 | 1.16252070 |
| 40 | TAOK1 | 1.15918111 |
| 41 | LATS2 | 1.06236245 |
| 42 | CAMK2B | 1.05270751 |
| 43 | CDK19 | 1.04763578 |
| 44 | CAMK2A | 1.03854455 |
| 45 | MAP2K6 | 1.03712985 |
| 46 | TESK1 | 1.03140623 |
| 47 | MAPK13 | 0.99742645 |
| 48 | SGK223 | 0.96552050 |
| 49 | SGK494 | 0.96552050 |
| 50 | MAP3K11 | 0.95316350 |
| 51 | CAMKK2 | 0.94450664 |
| 52 | ERN1 | 0.93882575 |
| 53 | PNCK | 0.90923727 |
| 54 | FGFR2 | 0.90482504 |
| 55 | CAMK1 | 0.89673964 |
| 56 | MST1R | 0.89155694 |
| 57 | CDK18 | 0.88389657 |
| 58 | CDK15 | 0.86946919 |
| 59 | SGK1 | 0.85063212 |
| 60 | STK39 | 0.84071535 |
| 61 | CDK14 | 0.83872611 |
| 62 | UHMK1 | 0.83538097 |
| 63 | PINK1 | 0.80626764 |
| 64 | STK11 | 0.80314050 |
| 65 | PDK1 | 0.77907110 |
| 66 | SGK2 | 0.76849396 |
| 67 | PDPK1 | 0.76749691 |
| 68 | CDK11A | 0.76283285 |
| 69 | MAP3K1 | 0.75962083 |
| 70 | PRKCH | 0.71743649 |
| 71 | FGFR3 | 0.71089250 |
| 72 | TNK2 | 0.70547395 |
| 73 | OXSR1 | 0.68534036 |
| 74 | FGFR4 | 0.65966033 |
| 75 | SGK3 | 0.65778128 |
| 76 | FGR | 0.65025606 |
| 77 | MARK2 | 0.62952515 |
| 78 | NME1 | 0.62720259 |
| 79 | RET | 0.62012767 |
| 80 | ERBB2 | 0.61342879 |
| 81 | NEK6 | 0.61274439 |
| 82 | DYRK1A | 0.61034292 |
| 83 | PAK3 | 0.59593334 |
| 84 | MAP2K1 | 0.59250711 |
| 85 | MAPK12 | 0.57919479 |
| 86 | DMPK | 0.57872126 |
| 87 | BRAF | 0.56137296 |
| 88 | EPHA2 | 0.54242680 |
| 89 | MOS | 0.53152527 |
| 90 | RPS6KA3 | 0.52317730 |
| 91 | BRSK1 | 0.51805661 |
| 92 | CAMK2D | 0.50320456 |
| 93 | LMTK2 | 0.49082841 |
| 94 | FRK | 0.48970785 |
| 95 | PRKCZ | 0.47706509 |
| 96 | FYN | 0.47462463 |
| 97 | CAMK2G | 0.45724774 |
| 98 | MAPK10 | 0.45368245 |
| 99 | LIMK1 | 0.44283566 |
| 100 | ALK | 0.43852230 |
| 101 | PIK3CA | 0.42588325 |
| 102 | PHKG2 | 0.42392594 |
| 103 | PHKG1 | 0.42392594 |
| 104 | PRKCE | 0.41436361 |
| 105 | MAP3K7 | 0.41042244 |
| 106 | MAPKAPK5 | 0.40644376 |
| 107 | DAPK3 | 0.38987917 |
| 108 | SRC | 0.37139102 |
| 109 | PRKD2 | 0.36372603 |
| 110 | JAK2 | 0.36101445 |
| 111 | CAMK4 | 0.35401429 |
| 112 | TESK2 | 0.34446915 |
| 113 | GRK7 | 0.34147156 |
| 114 | PRKACG | 0.33906345 |
| 115 | PRKCB | 0.33275847 |
| 116 | PRKCQ | 0.31765413 |
| 117 | PRKCA | 0.30881127 |
| 118 | MUSK | 0.30230855 |
| 119 | FER | 0.29971313 |
| 120 | CSNK1G2 | 0.28630698 |
| 121 | CSNK1A1 | 0.28339037 |
| 122 | CDC42BPA | 0.27047939 |
| 123 | PRKACA | 0.26649265 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.61944363 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.27340970 |
| 3 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.09985022 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 3.03511186 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.86056714 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.83540925 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.76092844 |
| 8 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.75478741 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.68189142 |
| 10 | GABAergic synapse_Homo sapiens_hsa04727 | 2.62869221 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.62387310 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.33887042 |
| 13 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.30270409 |
| 14 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.29739417 |
| 15 | Renin-angiotensin system_Homo sapiens_hsa04614 | 2.16952144 |
| 16 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.15471938 |
| 17 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.07771234 |
| 18 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.02635285 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.99080243 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.98167469 |
| 21 | Histidine metabolism_Homo sapiens_hsa00340 | 1.94926782 |
| 22 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.94643442 |
| 23 | Insulin secretion_Homo sapiens_hsa04911 | 1.93451139 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.92904020 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.92716233 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.78385005 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.78062451 |
| 28 | Long-term depression_Homo sapiens_hsa04730 | 1.75218085 |
| 29 | Taste transduction_Homo sapiens_hsa04742 | 1.71893721 |
| 30 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.66227230 |
| 31 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.65109021 |
| 32 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.55642228 |
| 33 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.50311770 |
| 34 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.49337030 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.43921141 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.41951086 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.39053108 |
| 38 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.38437634 |
| 39 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.37201756 |
| 40 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.33994669 |
| 41 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.32483419 |
| 42 | Glioma_Homo sapiens_hsa05214 | 1.26178188 |
| 43 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.26047467 |
| 44 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.19734905 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.12753280 |
| 46 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.10390925 |
| 47 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.08948098 |
| 48 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.08643611 |
| 49 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.04571136 |
| 50 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.04059142 |
| 51 | Melanogenesis_Homo sapiens_hsa04916 | 1.03303572 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.02633740 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.02453685 |
| 54 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.00779175 |
| 55 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.00636502 |
| 56 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.97216240 |
| 57 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.96432230 |
| 58 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.96323277 |
| 59 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.96101209 |
| 60 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.95889616 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.95464675 |
| 62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.93930728 |
| 63 | Axon guidance_Homo sapiens_hsa04360 | 0.93367690 |
| 64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.92743598 |
| 65 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.91887894 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.91058898 |
| 67 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90917333 |
| 68 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.90456696 |
| 69 | Phototransduction_Homo sapiens_hsa04744 | 0.89595745 |
| 70 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.89307477 |
| 71 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.87933098 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.86570483 |
| 73 | Alcoholism_Homo sapiens_hsa05034 | 0.86339171 |
| 74 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85899533 |
| 75 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.85667980 |
| 76 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.81363325 |
| 77 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.80927798 |
| 78 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.80609017 |
| 79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.79409237 |
| 80 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.75828153 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.74529794 |
| 82 | Galactose metabolism_Homo sapiens_hsa00052 | 0.72912534 |
| 83 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.71136725 |
| 84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.70712523 |
| 85 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.67600171 |
| 86 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66971159 |
| 87 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.66614222 |
| 88 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.65253120 |
| 89 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.64792287 |
| 90 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.64238323 |
| 91 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.63853755 |
| 92 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.62982675 |
| 93 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.62088836 |
| 94 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.60534661 |
| 95 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.60452861 |
| 96 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.60324355 |
| 97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.59628690 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.58828001 |
| 99 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.57352312 |
| 100 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.56925253 |
| 101 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.56341642 |
| 102 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.56295286 |
| 103 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.55879179 |
| 104 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.55660234 |
| 105 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.54937695 |
| 106 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54112786 |
| 107 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.53831123 |
| 108 | Bile secretion_Homo sapiens_hsa04976 | 0.51896651 |
| 109 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.49077927 |
| 110 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47761484 |
| 111 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.46725415 |
| 112 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46625948 |
| 113 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.44888366 |
| 114 | Endocytosis_Homo sapiens_hsa04144 | 0.44410894 |
| 115 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.44312204 |
| 116 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43893157 |
| 117 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.43041910 |
| 118 | Prion diseases_Homo sapiens_hsa05020 | 0.42488098 |
| 119 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.42265581 |
| 120 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.41212608 |
| 121 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.40811360 |
| 122 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.39561185 |
| 123 | Alzheimers disease_Homo sapiens_hsa05010 | 0.37078922 |
| 124 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35921207 |
| 125 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35381073 |
| 126 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33532293 |
| 127 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33439294 |
| 128 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.33190515 |
| 129 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.32903854 |
| 130 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32515054 |
| 131 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31919490 |
| 132 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.30553846 |
| 133 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.29623944 |
| 134 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.29570002 |
| 135 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.28760289 |
| 136 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.28549750 |
| 137 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.28395262 |
| 138 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.27550950 |
| 139 | Endometrial cancer_Homo sapiens_hsa05213 | 0.27131800 |
| 140 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.26549550 |
| 141 | Platelet activation_Homo sapiens_hsa04611 | 0.25879030 |
| 142 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24777365 |
| 143 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.24315789 |
| 144 | Mineral absorption_Homo sapiens_hsa04978 | 0.23466153 |
| 145 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.20747840 |

