SOWAHC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)6.82011718
2hemidesmosome assembly (GO:0031581)6.37364293
3establishment of skin barrier (GO:0061436)5.00532159
4bundle of His cell to Purkinje myocyte communication (GO:0086069)4.94815243
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67078699
6negative regulation of keratinocyte proliferation (GO:0010839)4.60319550
7regulation of water loss via skin (GO:0033561)4.49152977
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44683065
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.44683065
10modulation by symbiont of host immune response (GO:0052553)4.44683065
11positive regulation by symbiont of host defense response (GO:0052509)4.44683065
12modulation by symbiont of host defense response (GO:0052031)4.44683065
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44683065
14keratinocyte proliferation (GO:0043616)4.40941204
15gap junction assembly (GO:0016264)4.24784254
16low-density lipoprotein particle clearance (GO:0034383)3.88617240
17macrophage activation involved in immune response (GO:0002281)3.76197350
18neutrophil activation involved in immune response (GO:0002283)3.75576660
19keratinocyte differentiation (GO:0030216)3.74935429
20response to muramyl dipeptide (GO:0032495)3.66359634
21COPI coating of Golgi vesicle (GO:0048205)3.64419071
22Golgi transport vesicle coating (GO:0048200)3.64419071
23growth hormone receptor signaling pathway (GO:0060396)3.59525957
24chondrocyte proliferation (GO:0035988)3.57745418
25response to peptidoglycan (GO:0032494)3.48051985
26microglial cell activation (GO:0001774)3.43314340
27regulation of keratinocyte proliferation (GO:0010837)3.41541364
28positive regulation of cellular amide metabolic process (GO:0034250)3.41194236
29molting cycle (GO:0042303)3.40352196
30hair cycle (GO:0042633)3.40352196
31polarized epithelial cell differentiation (GO:0030859)3.33174706
32anterior/posterior axis specification, embryo (GO:0008595)3.25579893
33regulation of interferon-beta biosynthetic process (GO:0045357)3.24161568
34negative regulation of fibrinolysis (GO:0051918)3.23752917
35negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.20210878
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19862401
37regulation of hippo signaling (GO:0035330)3.16428499
38NIK/NF-kappaB signaling (GO:0038061)3.13694499
39negative regulation of lipid storage (GO:0010888)3.13652731
40cellular response to growth hormone stimulus (GO:0071378)3.13643290
41positive regulation of interferon-alpha production (GO:0032727)3.13546793
42intestinal cholesterol absorption (GO:0030299)3.13168700
43multicellular organismal water homeostasis (GO:0050891)3.11672637
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10932605
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09160202
46antigen processing and presentation of endogenous antigen (GO:0019883)3.07621714
47keratinocyte development (GO:0003334)3.07394175
48hydrogen peroxide biosynthetic process (GO:0050665)3.06713468
49regulation of cholesterol storage (GO:0010885)3.05822511
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04953299
51epidermal cell differentiation (GO:0009913)3.04951503
52T-helper 1 type immune response (GO:0042088)3.02139173
53granulocyte activation (GO:0036230)3.01606537
54epidermis development (GO:0008544)3.01223150
55response to lipoprotein particle (GO:0055094)3.01182712
56regulation of fibrinolysis (GO:0051917)3.00165623
57skin morphogenesis (GO:0043589)2.97644192
58positive regulation of interleukin-12 production (GO:0032735)2.97048293
59interleukin-1-mediated signaling pathway (GO:0070498)2.95112599
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93295634
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93295634
62regulation of interferon-alpha production (GO:0032647)2.93116450
63positive regulation of antigen processing and presentation (GO:0002579)2.91516004
64neutrophil activation (GO:0042119)2.90943564
65atrioventricular valve morphogenesis (GO:0003181)2.90927190
66positive regulation of heat generation (GO:0031652)2.90671011
67regulation of gonadotropin secretion (GO:0032276)2.88733606
68positive regulation of p38MAPK cascade (GO:1900745)2.81444741
69cellular glucuronidation (GO:0052695)2.80217512
70macrophage activation (GO:0042116)2.80187396
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78545561
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78044063
73response to host immune response (GO:0052572)2.78044063
74regulation of interleukin-12 biosynthetic process (GO:0045075)2.77217229
75notochord development (GO:0030903)2.75939545
76ectoderm development (GO:0007398)2.75771233
77desmosome organization (GO:0002934)2.75688068
78positive regulation of chemokine biosynthetic process (GO:0045080)2.75580752
79cytokine secretion (GO:0050663)2.74628525
80regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.65616831
81regulation of transforming growth factor beta2 production (GO:0032909)2.65587893
82glucuronate metabolic process (GO:0019585)2.64381343
83uronic acid metabolic process (GO:0006063)2.64381343
84embryonic foregut morphogenesis (GO:0048617)2.64344686
85positive regulation of macrophage cytokine production (GO:0060907)2.63877949
86regulation of transforming growth factor beta1 production (GO:0032908)2.63841827
87apoptotic cell clearance (GO:0043277)2.63611291
88UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63597827
89nodal signaling pathway (GO:0038092)2.63403166
90intestinal absorption (GO:0050892)2.62688583
91cell migration involved in sprouting angiogenesis (GO:0002042)2.62406327
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61599088
93regulation of plasminogen activation (GO:0010755)2.61559741
94epithelial cell-cell adhesion (GO:0090136)2.61169605
95cell adhesion mediated by integrin (GO:0033627)2.60765811
96reactive oxygen species biosynthetic process (GO:1903409)2.60717478
97positive regulation of cholesterol efflux (GO:0010875)2.60456080
98positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.60245555
99respiratory burst (GO:0045730)2.59816134
100macroautophagy (GO:0016236)2.59254105
101I-kappaB phosphorylation (GO:0007252)2.58945747
102intestinal epithelial cell development (GO:0060576)2.58862057
103regulation of cell proliferation involved in kidney development (GO:1901722)2.57870946
104regulation of cardioblast differentiation (GO:0051890)2.57125486
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56713210
106water homeostasis (GO:0030104)2.56657130
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53699045
108response to host (GO:0075136)2.53699045
109response to host defenses (GO:0052200)2.53699045
110positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.52937949
111intermediate filament organization (GO:0045109)2.52383350
112regulation of fever generation (GO:0031620)2.52179198
113positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.52076850
114negative regulation of protein activation cascade (GO:2000258)2.51910105
115positive regulation of chemokine production (GO:0032722)2.51607858
116regulation of protein activation cascade (GO:2000257)2.51376852
117establishment of tissue polarity (GO:0007164)2.50747292
118establishment of planar polarity (GO:0001736)2.50747292
119cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.50290114
120negative regulation of interleukin-17 production (GO:0032700)2.48983842
121cardiac right ventricle morphogenesis (GO:0003215)2.48673852
122eosinophil chemotaxis (GO:0048245)2.47404712
123very-low-density lipoprotein particle assembly (GO:0034379)2.47257646
124natural killer cell mediated cytotoxicity (GO:0042267)2.45682895
125natural killer cell mediated immunity (GO:0002228)2.45682895
126regulation of interleukin-12 production (GO:0032655)2.44237243
127protein carboxylation (GO:0018214)2.44227834
128peptidyl-glutamic acid carboxylation (GO:0017187)2.44227834
129regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.42649332
130neural crest cell development (GO:0014032)2.42288818
131positive regulation of interferon-beta production (GO:0032728)2.42185631
132regulation of antigen processing and presentation (GO:0002577)2.42056391
133positive regulation of interleukin-6 production (GO:0032755)2.41887674
134positive regulation of male gonad development (GO:2000020)2.41807896
135detection of molecule of bacterial origin (GO:0032490)2.40759734
136regulation of complement activation (GO:0030449)2.39795704
137activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39033184
138regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.38998197
139wound healing, spreading of epidermal cells (GO:0035313)2.38715092
140L-phenylalanine metabolic process (GO:0006558)2.37888303
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37888303
142negative regulation of lipase activity (GO:0060192)2.37521735
143cysteine metabolic process (GO:0006534)2.35660187
144smooth muscle tissue development (GO:0048745)2.35153138
145cellular zinc ion homeostasis (GO:0006882)2.34806151
146retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34282011
147regulation of heat generation (GO:0031650)2.34157248
148fibrinolysis (GO:0042730)2.33979348
149positive regulation of natural killer cell differentiation (GO:0032825)2.33345558
150response to follicle-stimulating hormone (GO:0032354)2.32982260
151L-phenylalanine catabolic process (GO:0006559)2.32274005
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32274005
153regulation of cholesterol homeostasis (GO:2000188)2.32183912
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.31963361
155myeloid dendritic cell differentiation (GO:0043011)2.31636111
156L-serine transport (GO:0015825)2.31347081
157positive regulation of sterol transport (GO:0032373)2.31324880
158positive regulation of cholesterol transport (GO:0032376)2.31324880
159high-density lipoprotein particle remodeling (GO:0034375)2.30682976
160negative regulation of bone resorption (GO:0045779)2.30624506
161regulation of podosome assembly (GO:0071801)2.30523050
162positive regulation of glomerulus development (GO:0090193)2.30228199
163activin receptor signaling pathway (GO:0032924)2.29672897
164male genitalia development (GO:0030539)2.28929345
165regulation of chemokine biosynthetic process (GO:0045073)2.28737184
166cellular response to vitamin D (GO:0071305)2.28460685
167pattern specification involved in kidney development (GO:0061004)2.28394153
168cellular response to vitamin (GO:0071295)2.28156518
169exocrine pancreas development (GO:0031017)2.28110073
170hippo signaling (GO:0035329)2.28080082
171sequestering of metal ion (GO:0051238)2.27058727
172response to nitrosative stress (GO:0051409)2.26919382
173positive regulation of leukocyte degranulation (GO:0043302)2.26825637
174dorsal/ventral axis specification (GO:0009950)2.26678962
175myeloid cell activation involved in immune response (GO:0002275)2.25931000
176positive regulation of type 2 immune response (GO:0002830)2.24977276
177peptide hormone processing (GO:0016486)2.24926261
178immunoglobulin mediated immune response (GO:0016064)2.24338278
179cellular response to zinc ion (GO:0071294)2.23882042
180cellular response to interferon-alpha (GO:0035457)2.23793632
181cholesterol biosynthetic process (GO:0006695)2.22984661
182regulation of mesoderm development (GO:2000380)2.22207129
183epithelial tube branching involved in lung morphogenesis (GO:0060441)2.21909478
184female gonad development (GO:0008585)2.21071746
185negative regulation of complement activation (GO:0045916)2.20914139
186regulation of transforming growth factor beta production (GO:0071634)2.19123745
187plasma lipoprotein particle clearance (GO:0034381)2.19057792
188lateral sprouting from an epithelium (GO:0060601)2.18121259
189ER overload response (GO:0006983)2.17428068
190midgut development (GO:0007494)2.16425890
191cell-substrate junction assembly (GO:0007044)2.16076674
192drug transmembrane transport (GO:0006855)2.15428831
193chemical homeostasis within a tissue (GO:0048875)2.13380336
194endocardial cushion development (GO:0003197)2.12968083
195sterol biosynthetic process (GO:0016126)2.11980092
196regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.11798652
197macromolecular complex remodeling (GO:0034367)2.11655371
198plasma lipoprotein particle remodeling (GO:0034369)2.11655371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.01821236
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77155722
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.49870445
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.35105694
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88377521
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84253879
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.79612275
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77670906
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.68473550
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.62768930
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.56143486
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.55697094
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46418578
14AR_21909140_ChIP-Seq_LNCAP_Human2.34358587
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34126261
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26309264
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22829730
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21177246
19GATA1_22025678_ChIP-Seq_K562_Human2.20220941
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14106966
21CLOCK_20551151_ChIP-Seq_293T_Human2.00722254
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.97836334
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91878925
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.91512347
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84329238
26TP53_18474530_ChIP-ChIP_U2OS_Human1.82637641
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.79871350
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76293979
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70765967
30VDR_24787735_ChIP-Seq_THP-1_Human1.69956629
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66779299
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.65473623
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64397170
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61530592
35ZNF263_19887448_ChIP-Seq_K562_Human1.60726730
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.58527905
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.55111164
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54383664
39ZNF274_21170338_ChIP-Seq_K562_Hela1.53540532
40SOX2_20726797_ChIP-Seq_SW620_Human1.52460575
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.51119599
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50696830
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46432949
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44692759
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43110879
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40298290
47CJUN_26792858_Chip-Seq_BT549_Human1.40063466
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39480999
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.38177003
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.37705758
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35709749
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35709749
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35671602
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35529775
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35017407
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33319136
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30610974
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.28987977
59RUNX_20019798_ChIP-Seq_JUKART_Human1.28788146
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28008953
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27814203
62TP53_16413492_ChIP-PET_HCT116_Human1.27453087
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27257299
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.25614387
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25481743
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25073804
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24914134
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24814171
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23560862
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23560862
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21473519
72FUS_26573619_Chip-Seq_HEK293_Human1.21433946
73SMAD3_21741376_ChIP-Seq_HESCs_Human1.20672304
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20546752
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16729606
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16450487
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16102131
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15805005
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.15728890
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15454609
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14658421
82AHR_22903824_ChIP-Seq_MCF-7_Human1.14120538
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14076844
84CDX2_22108803_ChIP-Seq_LS180_Human1.13178405
85BRD4_25478319_ChIP-Seq_HGPS_Human1.13014805
86GATA6_25053715_ChIP-Seq_YYC3_Human1.12991335
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.11725094
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10556060
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10470669
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10178577
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08278389
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08196357
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07737342
94SPI1_23127762_ChIP-Seq_K562_Human1.07251496
95PU_27001747_Chip-Seq_BMDM_Mouse1.06930672
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06930242
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06717742
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06649981
99VDR_24763502_ChIP-Seq_THP-1_Human1.06589616
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04917758
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03622039
102P300_19829295_ChIP-Seq_ESCs_Human1.03506310
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03293150
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.02695093
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00190339
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.99883017
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99850417
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99219114
109TAF15_26573619_Chip-Seq_HEK293_Human0.99104482
110GATA3_27048872_Chip-Seq_THYMUS_Human0.98957599
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98953069
112TP63_23658742_ChIP-Seq_EP156T_Human0.98872870
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98466099
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.97932758
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96876378
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.96853362
117GBX2_23144817_ChIP-Seq_PC3_Human0.96236458
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95733792
119TCF4_22108803_ChIP-Seq_LS180_Human0.95029095
120EWS_26573619_Chip-Seq_HEK293_Human0.94064851
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93199645
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93050149
123ATF3_27146783_Chip-Seq_COLON_Human0.92617550
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92475649
125GATA3_26560356_Chip-Seq_TH2_Human0.91576659
126GATA1_19941826_ChIP-Seq_K562_Human0.90923414
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90734373
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.90606582
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90603773
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90575669
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90399754
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90297140
133GATA4_25053715_ChIP-Seq_YYC3_Human0.89076946
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89051004
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89006694
136RXR_22108803_ChIP-Seq_LS180_Human0.88199392
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88066304
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.88038247
139TCF7_22412390_ChIP-Seq_EML_Mouse0.87688681
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.87556998
141MYB_26560356_Chip-Seq_TH2_Human0.87189658
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86347724
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86187194
144ELK1_19687146_ChIP-ChIP_HELA_Human0.85671095
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85141747
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84979818
147AR_25329375_ChIP-Seq_VCAP_Human0.84314314
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84182878
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84016743
150AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83972152
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.83951689
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83921950
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83914525
154TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83751031
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.82904661
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82749516
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.81446780
158IGF1R_20145208_ChIP-Seq_DFB_Human0.81032775
159HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80959188
160PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80692585
161CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80683977
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.80291543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.49862127
2MP0003941_abnormal_skin_development3.87912528
3MP0002877_abnormal_melanocyte_morpholog3.02559186
4MP0010234_abnormal_vibrissa_follicle2.85368811
5MP0003183_abnormal_peptide_metabolism2.84780699
6MP0003436_decreased_susceptibility_to2.78085456
7MP0002254_reproductive_system_inflammat2.75227934
8MP0000566_synostosis2.70299324
9MP0001835_abnormal_antigen_presentation2.69614185
10MP0000762_abnormal_tongue_morphology2.56406009
11MP0005501_abnormal_skin_physiology2.56242192
12MP0003303_peritoneal_inflammation2.51773321
13MP0005058_abnormal_lysosome_morphology2.49950772
14MP0003724_increased_susceptibility_to2.38194806
15MP0004947_skin_inflammation2.26730297
16MP0002148_abnormal_hypersensitivity_rea2.25828584
17MP0000467_abnormal_esophagus_morphology2.24895882
18MP0004272_abnormal_basement_membrane2.18271783
19MP0002419_abnormal_innate_immunity2.13358504
20MP0003191_abnormal_cellular_cholesterol2.12927785
21MP0009053_abnormal_anal_canal2.12207739
22MP0003950_abnormal_plasma_membrane2.11680868
23MP0006082_CNS_inflammation2.09043918
24MP0005000_abnormal_immune_tolerance2.08989506
25MP0004185_abnormal_adipocyte_glucose2.08209926
26MP0003300_gastrointestinal_ulcer2.06751835
27MP0002138_abnormal_hepatobiliary_system2.05761609
28MP0009780_abnormal_chondrocyte_physiolo2.02849432
29MP0009785_altered_susceptibility_to2.02044126
30MP0008875_abnormal_xenobiotic_pharmacok1.98921723
31MP0003890_abnormal_embryonic-extraembry1.98239110
32MP0000569_abnormal_digit_pigmentation1.92534095
33MP0004510_myositis1.91751520
34MP0002139_abnormal_hepatobiliary_system1.87440921
35MP0005076_abnormal_cell_differentiation1.83086443
36MP0001533_abnormal_skeleton_physiology1.81170034
37MP0003453_abnormal_keratinocyte_physiol1.80455569
38MP0002693_abnormal_pancreas_physiology1.74780164
39MP0001790_abnormal_immune_system1.74328936
40MP0005387_immune_system_phenotype1.74328936
41MP0005085_abnormal_gallbladder_physiolo1.73734428
42MP0005275_abnormal_skin_tensile1.73593806
43MP0003172_abnormal_lysosome_physiology1.72053416
44MP0005360_urolithiasis1.68992951
45MP0005365_abnormal_bile_salt1.67932427
46MP0005670_abnormal_white_adipose1.65238682
47MP0005025_abnormal_response_to1.64851549
48MP0002006_tumorigenesis1.64487885
49MP0005257_abnormal_intraocular_pressure1.64131898
50MP0005666_abnormal_adipose_tissue1.63520801
51MP0003045_fibrosis1.63107122
52MP0010771_integument_phenotype1.61731849
53MP0000685_abnormal_immune_system1.61325275
54MP0002796_impaired_skin_barrier1.60136195
55MP0002452_abnormal_antigen_presenting1.57765537
56MP0003937_abnormal_limbs/digits/tail_de1.57020086
57MP0004782_abnormal_surfactant_physiolog1.50962767
58MP0002234_abnormal_pharynx_morphology1.50919777
59MP0000537_abnormal_urethra_morphology1.49816377
60MP0000013_abnormal_adipose_tissue1.49342539
61MP0002998_abnormal_bone_remodeling1.48857841
62MP0002723_abnormal_immune_serum1.46970919
63MP0002166_altered_tumor_susceptibility1.46545136
64MP0003315_abnormal_perineum_morphology1.45633986
65MP0000647_abnormal_sebaceous_gland1.44952845
66MP0005310_abnormal_salivary_gland1.44721765
67MP0005379_endocrine/exocrine_gland_phen1.43799830
68MP0004264_abnormal_extraembryonic_tissu1.43529530
69MP0005375_adipose_tissue_phenotype1.43094260
70MP0003566_abnormal_cell_adhesion1.41434790
71MP0003195_calcinosis1.38680380
72MP0010678_abnormal_skin_adnexa1.38168634
73MP0005023_abnormal_wound_healing1.36074671
74MP0005671_abnormal_response_to1.34143057
75MP0000427_abnormal_hair_cycle1.33202723
76MP0003283_abnormal_digestive_organ1.32081399
77MP0003448_altered_tumor_morphology1.31281918
78MP0000377_abnormal_hair_follicle1.28746825
79MP0001800_abnormal_humoral_immune1.28168053
80MP0001216_abnormal_epidermal_layer1.27604516
81MP0000383_abnormal_hair_follicle1.26711936
82MP0002697_abnormal_eye_size1.26203153
83MP0002009_preneoplasia1.25839220
84MP0003755_abnormal_palate_morphology1.25736866
85MP0003705_abnormal_hypodermis_morpholog1.24893873
86MP0002909_abnormal_adrenal_gland1.23997446
87MP0001845_abnormal_inflammatory_respons1.23954650
88MP0009840_abnormal_foam_cell1.20747809
89MP0001819_abnormal_immune_cell1.20134228
90MP0002282_abnormal_trachea_morphology1.19995122
91MP0001944_abnormal_pancreas_morphology1.18217788
92MP0010329_abnormal_lipoprotein_level1.16181055
93MP0002111_abnormal_tail_morphology1.15675318
94MP0010352_gastrointestinal_tract_polyps1.15244403
95MP0002420_abnormal_adaptive_immunity1.15209840
96MP0001853_heart_inflammation1.14801172
97MP0004130_abnormal_muscle_cell1.13974095
98MP0009384_cardiac_valve_regurgitation1.13602653
99MP0003136_yellow_coat_color1.12370897
100MP0005167_abnormal_blood-brain_barrier1.12362225
101MP0002060_abnormal_skin_morphology1.10658330
102MP0000003_abnormal_adipose_tissue1.09682521
103MP0010386_abnormal_urinary_bladder1.09648609
104MP0008469_abnormal_protein_level1.09057067
105MP0005464_abnormal_platelet_physiology1.08747061
106MP0002089_abnormal_postnatal_growth/wei1.05947630
107MP0009697_abnormal_copulation1.04735035
108MP0003011_delayed_dark_adaptation1.03594904
109MP0009764_decreased_sensitivity_to1.01958366
110MP0003075_altered_response_to1.01867061
111MP0003690_abnormal_glial_cell1.01528338
112MP0003828_pulmonary_edema1.01072268
113MP0003091_abnormal_cell_migration1.00695702
114MP0001666_abnormal_nutrient_absorption1.00693287
115MP0008961_abnormal_basal_metabolism0.99890104
116MP0003119_abnormal_digestive_system0.99689160
117MP0003252_abnormal_bile_duct0.98088702
118MP0002277_abnormal_respiratory_mucosa0.96977505
119MP0001286_abnormal_eye_development0.96613769
120MP0010155_abnormal_intestine_physiology0.94578932
121MP0001661_extended_life_span0.94357012
122MP0009278_abnormal_bone_marrow0.94346059
123MP0010368_abnormal_lymphatic_system0.92421083
124MP0002938_white_spotting0.92389582
125MP0001346_abnormal_lacrimal_gland0.92149528
126MP0001851_eye_inflammation0.91511061
127MP0002098_abnormal_vibrissa_morphology0.91033373
128MP0005197_abnormal_uvea_morphology0.89794056
129MP0001299_abnormal_eye_distance/0.89190307
130MP0005390_skeleton_phenotype0.89050926
131MP0002971_abnormal_brown_adipose0.88722803
132MP0005334_abnormal_fat_pad0.88054752
133MP0002078_abnormal_glucose_homeostasis0.87082787
134MP0002896_abnormal_bone_mineralization0.87013468
135MP0006054_spinal_hemorrhage0.86927012
136MP0002928_abnormal_bile_duct0.86847507
137MP0010030_abnormal_orbit_morphology0.86807760
138MP0000516_abnormal_urinary_system0.86688888
139MP0005367_renal/urinary_system_phenotyp0.86688888
140MP0001340_abnormal_eyelid_morphology0.86454973
141MP0002405_respiratory_system_inflammati0.86370092
142MP0003868_abnormal_feces_composition0.86245390
143MP0003718_maternal_effect0.86213090
144MP0009250_abnormal_appendicular_skeleto0.85895146
145MP0005535_abnormal_body_temperature0.85773403
146MP0002233_abnormal_nose_morphology0.85256299
147MP0000627_abnormal_mammary_gland0.84864779
148MP0005332_abnormal_amino_acid0.84200451
149MP0000371_diluted_coat_color0.81572127
150MP0002092_abnormal_eye_morphology0.80712257
151MP0004043_abnormal_pH_regulation0.80521489
152MP0000858_altered_metastatic_potential0.79544801
153MP0008004_abnormal_stomach_pH0.79411604
154MP0004019_abnormal_vitamin_homeostasis0.78982031
155MP0002168_other_aberrant_phenotype0.78346032
156MP0003795_abnormal_bone_structure0.75677282
157MP0005164_abnormal_response_to0.75493807
158MP0003122_maternal_imprinting0.75022259
159MP0000432_abnormal_head_morphology0.74183570
160MP0000538_abnormal_urinary_bladder0.73940448
161MP0000462_abnormal_digestive_system0.72983187
162MP0001849_ear_inflammation0.72609002
163MP0004133_heterotaxia0.71454924
164MP0002084_abnormal_developmental_patter0.66224135
165MP0009931_abnormal_skin_appearance0.64885230
166MP0004885_abnormal_endolymph0.64414744
167MP0000367_abnormal_coat/_hair0.64232413
168MP0005409_darkened_coat_color0.60992267
169MP0001191_abnormal_skin_condition0.60715304
170MP0002876_abnormal_thyroid_physiology0.59615205
171MP0001243_abnormal_dermal_layer0.58412111
172MP0002109_abnormal_limb_morphology0.58327410
173MP0005623_abnormal_meninges_morphology0.57981466
174MP0004197_abnormal_fetal_growth/weight/0.57754623
175MP0003693_abnormal_embryo_hatching0.57458174
176MP0002160_abnormal_reproductive_system0.57322546
177MP0005395_other_phenotype0.57075559
178MP0005187_abnormal_penis_morphology0.54829018
179MP0003936_abnormal_reproductive_system0.54771975
180MP0003935_abnormal_craniofacial_develop0.54648401
181MP0005508_abnormal_skeleton_morphology0.53979376

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)6.11512883
2Eczematoid dermatitis (HP:0000976)5.29138952
3Recurrent bacterial skin infections (HP:0005406)4.60117772
4Recurrent abscess formation (HP:0002722)4.45493842
5Palmar hyperkeratosis (HP:0010765)4.42807908
6Onycholysis (HP:0001806)4.18096402
7Alopecia of scalp (HP:0002293)4.12967884
8Fragile nails (HP:0001808)4.12441326
9Milia (HP:0001056)4.00942272
10Recurrent gram-negative bacterial infections (HP:0005420)3.91488500
11Increased cerebral lipofuscin (HP:0011813)3.81808778
12Systemic lupus erythematosus (HP:0002725)3.67967817
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.53666156
14Right ventricular cardiomyopathy (HP:0011663)3.52493591
15Hematochezia (HP:0002573)3.47163996
16Dysostosis multiplex (HP:0000943)3.39054316
17Insulin-resistant diabetes mellitus (HP:0000831)3.30587563
18Abnormality of glycolipid metabolism (HP:0010969)3.26430697
19Abnormality of liposaccharide metabolism (HP:0010968)3.26430697
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.26430697
21Hypoglycemic seizures (HP:0002173)3.21983037
22Myocardial infarction (HP:0001658)3.18634977
23Abnormality of macrophages (HP:0004311)3.17340416
24Mucopolysacchariduria (HP:0008155)3.14357032
25Urinary glycosaminoglycan excretion (HP:0003541)3.14357032
26Gingivitis (HP:0000230)3.08491344
27Interstitial pulmonary disease (HP:0006530)3.05282045
28Glomerulonephritis (HP:0000099)3.02648876
29Hyperinsulinemic hypoglycemia (HP:0000825)2.96641261
30Increased IgE level (HP:0003212)2.95876008
31Symptomatic seizures (HP:0011145)2.95474205
32Thick nail (HP:0001805)2.94588625
33Orchitis (HP:0100796)2.91333231
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90243524
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90243524
36Abnormality of polysaccharide metabolism (HP:0011012)2.90243524
37Hypotrichosis (HP:0001006)2.89151499
38Abnormality of the nasal septum (HP:0000419)2.88944536
39Periodontitis (HP:0000704)2.86964519
40Nail dystrophy (HP:0008404)2.86951523
41Congenital ichthyosiform erythroderma (HP:0007431)2.86124900
42Atrophic scars (HP:0001075)2.85887691
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.84271785
44Tetraparesis (HP:0002273)2.84025639
45Pterygium (HP:0001059)2.81036145
46Abnormality of secondary sexual hair (HP:0009888)2.79354804
47Abnormality of the axillary hair (HP:0100134)2.79354804
48Mediastinal lymphadenopathy (HP:0100721)2.78095857
49Deep venous thrombosis (HP:0002625)2.76341317
50Vacuolated lymphocytes (HP:0001922)2.75569096
51Hypobetalipoproteinemia (HP:0003563)2.73862787
52Autoimmune thrombocytopenia (HP:0001973)2.73277674
53Oral leukoplakia (HP:0002745)2.73144351
54Hypoglycemic coma (HP:0001325)2.71342579
55Vascular calcification (HP:0004934)2.68048411
56Prolonged partial thromboplastin time (HP:0003645)2.67613330
57Corneal erosion (HP:0200020)2.63514704
58Axonal loss (HP:0003447)2.59619492
59Retrobulbar optic neuritis (HP:0100654)2.57750958
60Optic neuritis (HP:0100653)2.57750958
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57617249
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.56836366
63Parakeratosis (HP:0001036)2.56108231
64Erythroderma (HP:0001019)2.55162117
65Elevated erythrocyte sedimentation rate (HP:0003565)2.52958477
66Hyperglycemia (HP:0003074)2.49773416
67Retinal atrophy (HP:0001105)2.48987211
68Sparse eyelashes (HP:0000653)2.46970078
69Osteolytic defects of the hand bones (HP:0009699)2.46071874
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.46071874
71Natal tooth (HP:0000695)2.44452044
72Recurrent skin infections (HP:0001581)2.44081686
73Cardiovascular calcification (HP:0011915)2.43015680
74Myositis (HP:0100614)2.42491009
75Abnormality of proline metabolism (HP:0010907)2.41700292
76Hydroxyprolinuria (HP:0003080)2.41700292
77Hypoplastic labia majora (HP:0000059)2.36186318
78Abnormality of carpal bone ossification (HP:0006257)2.35957308
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35419602
80Absent eyelashes (HP:0000561)2.35315612
81Nephritis (HP:0000123)2.31983072
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29473286
83Woolly hair (HP:0002224)2.28070186
84Intrahepatic cholestasis (HP:0001406)2.25151200
85Disinhibition (HP:0000734)2.23887841
86Pulmonary infiltrates (HP:0002113)2.21834064
87Recurrent fungal infections (HP:0002841)2.20960972
88Gastrointestinal infarctions (HP:0005244)2.19878620
89Acanthosis nigricans (HP:0000956)2.18737930
90Ectropion (HP:0000656)2.18715558
91Hypergammaglobulinemia (HP:0010702)2.18604851
92Conjugated hyperbilirubinemia (HP:0002908)2.18205747
93Vasculitis (HP:0002633)2.17506214
94Dry hair (HP:0011359)2.16826529
95Premature loss of primary teeth (HP:0006323)2.15393872
96Hypohidrosis (HP:0000966)2.15147338
97Popliteal pterygium (HP:0009756)2.14593028
98Follicular hyperkeratosis (HP:0007502)2.10608796
99Pili torti (HP:0003777)2.10380207
100Abnormality of the labia majora (HP:0012881)2.09701953
101Coronal craniosynostosis (HP:0004440)2.09138826
102Abnormality of the middle phalanges of the toes (HP:0010183)2.08517947
103Peritonitis (HP:0002586)2.02427149
104Basal ganglia calcification (HP:0002135)2.02375723
105Neonatal short-limb short stature (HP:0008921)2.02116910
106Prostate neoplasm (HP:0100787)2.01919984
107Advanced eruption of teeth (HP:0006288)2.01270389
108Cerebral aneurysm (HP:0004944)2.00885421
109Lip pit (HP:0100267)2.00708948
110Increased CSF protein (HP:0002922)2.00191411
111Ridged nail (HP:0001807)1.99513825
112Insulin resistance (HP:0000855)1.99377412
113Abnormal hair laboratory examination (HP:0003328)1.97044395
114Progressive visual loss (HP:0000529)1.94803227
115Segmental peripheral demyelination/remyelination (HP:0003481)1.93367003
116Labial hypoplasia (HP:0000066)1.93178239
117Abnormality of complement system (HP:0005339)1.92929143
118Palmoplantar keratoderma (HP:0000982)1.91692600
119Peripheral demyelination (HP:0011096)1.91445909
120Hypoplasia of dental enamel (HP:0006297)1.91277589
121Arterial thrombosis (HP:0004420)1.90900201
122Abnormality of the proximal phalanges of the hand (HP:0009834)1.90554945
123Abnormal ossification of hand bones (HP:0005921)1.90049307
124Abnormal hand bone ossification (HP:0010660)1.88105319
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87257528
126Absent hair (HP:0002298)1.86409129
127Breast hypoplasia (HP:0003187)1.85156884
128Bone pain (HP:0002653)1.85120634
129Colitis (HP:0002583)1.84421525
130Septate vagina (HP:0001153)1.83883512
131Complement deficiency (HP:0004431)1.83734127
132Short humerus (HP:0005792)1.83422275
133Hypoplastic female external genitalia (HP:0012815)1.83071494
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82399761
135Amyloidosis (HP:0011034)1.82339900
136Polygenic inheritance (HP:0010982)1.82285573
137Small epiphyses (HP:0010585)1.79395701
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79340509
139Cellulitis (HP:0100658)1.79105834
140Hypolipoproteinemia (HP:0010981)1.78730988
141Cortical dysplasia (HP:0002539)1.78187774
142Oligomenorrhea (HP:0000876)1.77685097
143Abnormal blistering of the skin (HP:0008066)1.77357946
144Recurrent viral infections (HP:0004429)1.76576007
145Esophageal varix (HP:0002040)1.76568125
146Short tibia (HP:0005736)1.76199830
147Recurrent corneal erosions (HP:0000495)1.74642436
148Aplasia/hypoplasia of the humerus (HP:0006507)1.74191225
149Abnormality of the gastric mucosa (HP:0004295)1.74139275
150Short hallux (HP:0010109)1.72791555
151Bifid scrotum (HP:0000048)1.72269093
152Esophageal atresia (HP:0002032)1.71198391
153Hypoplasia of the uterus (HP:0000013)1.69879555
154Progressive neurologic deterioration (HP:0002344)1.69813731
155Villous atrophy (HP:0011473)1.69114279
156Abnormality of small intestinal villus morphology (HP:0011472)1.69114279
157Plantar hyperkeratosis (HP:0007556)1.69022892
158Abnormality of the pericardium (HP:0001697)1.68786657
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.67177721
160Stomatitis (HP:0010280)1.67087074
161Vertebral clefting (HP:0008428)1.66992941
162Bone cyst (HP:0012062)1.66737328
163Fragile skin (HP:0001030)1.66714548
164Episodic fever (HP:0001954)1.63999307
165Mitral stenosis (HP:0001718)1.63786273
166Pustule (HP:0200039)1.63767211
167Laryngomalacia (HP:0001601)1.63228733
168Palmoplantar hyperkeratosis (HP:0000972)1.63112627
169Blepharitis (HP:0000498)1.62129552
170Skin nodule (HP:0200036)1.61844192
171Hemorrhage of the eye (HP:0011885)1.61144143
172Osteomyelitis (HP:0002754)1.60086504
173Glucose intolerance (HP:0000833)1.59635146
174Brittle hair (HP:0002299)1.59214529
175Duplicated collecting system (HP:0000081)1.58671407
176Aplasia cutis congenita (HP:0001057)1.58610610
177Deviation of the thumb (HP:0009603)1.57226422
178Xerostomia (HP:0000217)1.57083590
179Anonychia (HP:0001798)1.56999709
180Ureteral duplication (HP:0000073)1.56489525
181Abnormality of calcium-phosphate metabolism (HP:0100530)1.55965206
182Epidermoid cyst (HP:0200040)1.55943276
183Sparse scalp hair (HP:0002209)1.55893008
184Macroorchidism (HP:0000053)1.55817629
185Oligodontia (HP:0000677)1.55597978
186Depressed nasal tip (HP:0000437)1.53923804
187Abnormality of the 2nd finger (HP:0004100)1.53301707
188Aplasia/hypoplasia of the uterus (HP:0008684)1.52898185
189Abnormality of placental membranes (HP:0011409)1.52460680
190Amniotic constriction ring (HP:0009775)1.52460680
191Rickets (HP:0002748)1.52078687
192Erythema (HP:0010783)1.51539470
193Fair hair (HP:0002286)1.51218407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.76680657
2INSRR3.63847009
3MAPK153.21210141
4ERN13.13898595
5IRAK33.03320500
6LATS12.81738876
7WEE12.74500290
8TSSK62.65714636
9PNCK2.59311860
10STK38L2.55206735
11BRSK22.50127346
12TBK12.43248403
13RIPK42.41232053
14TYK22.37185308
15AKT32.19830668
16LATS22.16051306
17TAOK32.11747259
18ERBB42.10265304
19EPHA32.06950921
20JAK12.06346756
21FRK2.05421929
22IRAK42.03889599
23CAMK1D2.03131222
24RIPK12.01324822
25FGFR31.99727138
26CHUK1.98033443
27IKBKB1.92375631
28STK241.82690066
29EIF2AK31.79936105
30IRAK11.78694038
31JAK31.75888094
32TGFBR21.72770625
33TRIB31.68911933
34PDK21.66829586
35FGFR41.65126963
36STK391.63507655
37EPHB11.62997140
38MST1R1.62280117
39WNK41.60310312
40IKBKE1.58110137
41MKNK21.57833854
42ACVR1B1.57125240
43HIPK21.54950817
44MAP3K121.47555541
45PASK1.42118882
46MAP3K91.41463666
47CASK1.41248262
48CAMK1G1.39972992
49MAP3K131.36452462
50TRIM281.31624607
51PTK61.26840080
52TGFBR11.26700253
53MAP3K21.26281577
54MST41.21785599
55MAP3K11.18982594
56IRAK21.17829366
57CSK1.17277358
58JAK21.14551695
59FGFR11.13155282
60BLK1.12983114
61NUAK11.08894675
62ZAK1.05361055
63MAP3K31.04108875
64FER1.03489032
65MKNK10.98674603
66PIK3CA0.95580474
67ERBB30.94691619
68NEK10.93138118
69SIK10.92787697
70LMTK20.92216982
71TAF10.91915195
72PLK30.91776973
73PDGFRA0.91095349
74RPS6KA40.90950774
75TTK0.90812952
76NTRK10.89629767
77PRKAA20.89590827
78FLT30.85875502
79PAK40.84528274
80PLK40.84422514
81CSF1R0.84341474
82ZAP700.83397855
83PDGFRB0.80591886
84NEK90.80409249
85MAP2K20.79883030
86EIF2AK10.79185378
87MET0.77281915
88MAPKAPK30.76781217
89SRPK10.74824267
90DYRK1B0.72767579
91WNK30.71329991
92PAK20.67532133
93GSK3A0.67500544
94BMPR1B0.65189882
95RET0.63744973
96BUB10.63503984
97PBK0.63337462
98ABL20.63094054
99BRD40.62614482
100HCK0.61948028
101BMPR20.59631140
102BMX0.59354549
103EIF2AK20.58218087
104CSNK1G10.58175663
105MAP3K100.58105317
106MYLK0.57606338
107BCR0.56614804
108IGF1R0.55628292
109PIK3CG0.55285198
110RPS6KA20.55066434
111CDK60.54594484
112MAPKAPK20.53721126
113MAPKAPK50.53439568
114ITK0.53059353
115KIT0.52922354
116EGFR0.52154497
117BRSK10.52118583
118MELK0.51894631
119PLK10.51170074
120TRPM70.50808014
121LCK0.48698165
122ADRBK10.48279911
123SCYL20.48222369
124EPHA20.48122206
125CDK70.47518772
126FGFR20.47495043
127SYK0.47230850
128PTK20.47047133
129CSNK1A1L0.45568431
130PRKCI0.44757948
131STK30.44596152
132NEK60.43639236
133MARK30.43389265
134CDK120.42994189
135PLK20.42694307
136DMPK0.42294848
137STK100.41487380
138OXSR10.41039481
139EPHB20.39899382
140INSR0.39805770
141GRK70.39296980
142ABL10.38365025
143MAP4K10.38258606
144CSNK1G20.38083608
145GRK10.37661245
146PRKCE0.37428635
147CDK90.36237874
148BRAF0.34600568
149VRK10.34437268
150CSNK1E0.34424487
151CSNK1G30.34247268
152MTOR0.34153439
153STK160.33835003
154PIM20.33670205
155PRKCD0.33375366
156LYN0.33047490
157ROCK10.32822125
158TEC0.32699524
159TESK10.32203758
160SGK10.32135949
161MOS0.31885982
162MAP2K10.31318512
163NEK20.30879936
164DYRK30.30622502
165RPS6KA10.30455325
166NLK0.30263902
167MAP4K20.30165376
168MAP2K30.29827716
169DDR20.29742612

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92759490
2Steroid biosynthesis_Homo sapiens_hsa001002.85970681
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.83390153
4Leishmaniasis_Homo sapiens_hsa051402.48246277
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25867352
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13786823
7Osteoclast differentiation_Homo sapiens_hsa043802.13034536
8Legionellosis_Homo sapiens_hsa051342.12109897
9Caffeine metabolism_Homo sapiens_hsa002322.09435509
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.08824196
11Staphylococcus aureus infection_Homo sapiens_hsa051502.08180632
12Type I diabetes mellitus_Homo sapiens_hsa049402.06925960
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.02350477
14Lysosome_Homo sapiens_hsa041422.01535634
15Graft-versus-host disease_Homo sapiens_hsa053321.99938852
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97534111
17Retinol metabolism_Homo sapiens_hsa008301.90296235
18Pertussis_Homo sapiens_hsa051331.87597474
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86142300
20TNF signaling pathway_Homo sapiens_hsa046681.85838010
21Arginine biosynthesis_Homo sapiens_hsa002201.82624601
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.75167408
23Type II diabetes mellitus_Homo sapiens_hsa049301.72369166
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70735829
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65629839
26Tuberculosis_Homo sapiens_hsa051521.64049251
27ECM-receptor interaction_Homo sapiens_hsa045121.63911995
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.63752221
29Toxoplasmosis_Homo sapiens_hsa051451.63622600
30TGF-beta signaling pathway_Homo sapiens_hsa043501.59889595
31Chemical carcinogenesis_Homo sapiens_hsa052041.58271841
32Fat digestion and absorption_Homo sapiens_hsa049751.56288972
33Fatty acid degradation_Homo sapiens_hsa000711.55099199
34Histidine metabolism_Homo sapiens_hsa003401.53917566
35Vitamin B6 metabolism_Homo sapiens_hsa007501.49205497
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47503187
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46041267
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44775953
39Hippo signaling pathway_Homo sapiens_hsa043901.44471524
40Rheumatoid arthritis_Homo sapiens_hsa053231.42235608
41Selenocompound metabolism_Homo sapiens_hsa004501.39438458
42Linoleic acid metabolism_Homo sapiens_hsa005911.38010724
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37459027
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36963171
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36561742
46Nitrogen metabolism_Homo sapiens_hsa009101.36028704
47Malaria_Homo sapiens_hsa051441.35356756
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35212425
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33322937
50Influenza A_Homo sapiens_hsa051641.32727017
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32571701
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.32267205
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.29263253
54Antigen processing and presentation_Homo sapiens_hsa046121.29172987
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28665057
56Measles_Homo sapiens_hsa051621.27632732
57Allograft rejection_Homo sapiens_hsa053301.27015174
58Prion diseases_Homo sapiens_hsa050201.26460419
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26027828
60Propanoate metabolism_Homo sapiens_hsa006401.25654272
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24558147
62Tryptophan metabolism_Homo sapiens_hsa003801.24362101
63Phenylalanine metabolism_Homo sapiens_hsa003601.24148940
64Other glycan degradation_Homo sapiens_hsa005111.23052354
65Starch and sucrose metabolism_Homo sapiens_hsa005001.22646392
66Vitamin digestion and absorption_Homo sapiens_hsa049771.22606224
67Apoptosis_Homo sapiens_hsa042101.22437850
68Phagosome_Homo sapiens_hsa041451.21318867
69Insulin resistance_Homo sapiens_hsa049311.21305864
70Butanoate metabolism_Homo sapiens_hsa006501.19316373
71Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14951197
72Bile secretion_Homo sapiens_hsa049761.14577183
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13518691
74Arginine and proline metabolism_Homo sapiens_hsa003301.13364096
75Fatty acid metabolism_Homo sapiens_hsa012121.13168621
76p53 signaling pathway_Homo sapiens_hsa041151.12909225
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.12640293
78Protein export_Homo sapiens_hsa030601.12416613
79Tyrosine metabolism_Homo sapiens_hsa003501.10180049
80Pyruvate metabolism_Homo sapiens_hsa006201.08949386
81Jak-STAT signaling pathway_Homo sapiens_hsa046301.07520821
82Salmonella infection_Homo sapiens_hsa051321.07102964
83One carbon pool by folate_Homo sapiens_hsa006701.06996555
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05828641
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05692484
86Amoebiasis_Homo sapiens_hsa051461.05677103
87Prolactin signaling pathway_Homo sapiens_hsa049171.04749634
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04125269
89Dorso-ventral axis formation_Homo sapiens_hsa043201.03853541
90Chemokine signaling pathway_Homo sapiens_hsa040621.03613374
91B cell receptor signaling pathway_Homo sapiens_hsa046621.02853794
92Hepatitis C_Homo sapiens_hsa051601.01092550
93Sulfur metabolism_Homo sapiens_hsa009201.00634990
94Hedgehog signaling pathway_Homo sapiens_hsa043401.00576751
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00118277
96Fatty acid elongation_Homo sapiens_hsa000621.00099455
97African trypanosomiasis_Homo sapiens_hsa051430.98832962
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98630045
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98357481
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97997655
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95950667
102Ether lipid metabolism_Homo sapiens_hsa005650.95915948
103beta-Alanine metabolism_Homo sapiens_hsa004100.95172856
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94611695
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94260488
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92273629
107Circadian rhythm_Homo sapiens_hsa047100.90435545
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88535744
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.87962414
110Ovarian steroidogenesis_Homo sapiens_hsa049130.86632317
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85143172
112Hematopoietic cell lineage_Homo sapiens_hsa046400.84780705
113Basal cell carcinoma_Homo sapiens_hsa052170.84094681
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83934492
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80677829
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80400138
117Herpes simplex infection_Homo sapiens_hsa051680.79551383
118Hepatitis B_Homo sapiens_hsa051610.78274017
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75900504
120Vibrio cholerae infection_Homo sapiens_hsa051100.75867646
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75563532
122Acute myeloid leukemia_Homo sapiens_hsa052210.74958466
123Peroxisome_Homo sapiens_hsa041460.74360636
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.73729325
125Small cell lung cancer_Homo sapiens_hsa052220.73545320
126Chronic myeloid leukemia_Homo sapiens_hsa052200.73046046
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.71384798
128Sphingolipid metabolism_Homo sapiens_hsa006000.70455626
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69746987
130ABC transporters_Homo sapiens_hsa020100.69235805
131Glycerolipid metabolism_Homo sapiens_hsa005610.68913517
132Asthma_Homo sapiens_hsa053100.67326851
133Biosynthesis of amino acids_Homo sapiens_hsa012300.66960776
134Tight junction_Homo sapiens_hsa045300.64724734
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64546281
136Pancreatic cancer_Homo sapiens_hsa052120.63595528
137Arachidonic acid metabolism_Homo sapiens_hsa005900.62524511
138Proteoglycans in cancer_Homo sapiens_hsa052050.62044921
139Viral myocarditis_Homo sapiens_hsa054160.61653395
140N-Glycan biosynthesis_Homo sapiens_hsa005100.61235590
141Shigellosis_Homo sapiens_hsa051310.59852065
142Basal transcription factors_Homo sapiens_hsa030220.59162804
143Adherens junction_Homo sapiens_hsa045200.58990827
144Bladder cancer_Homo sapiens_hsa052190.58469258
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56816778
146Fatty acid biosynthesis_Homo sapiens_hsa000610.56076580
147PPAR signaling pathway_Homo sapiens_hsa033200.55737724
148Notch signaling pathway_Homo sapiens_hsa043300.55674828
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55560564
150Metabolic pathways_Homo sapiens_hsa011000.53714691
151Prostate cancer_Homo sapiens_hsa052150.53226541
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52953752
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52723216
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.52499536
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.52058066
156Axon guidance_Homo sapiens_hsa043600.51078222
157T cell receptor signaling pathway_Homo sapiens_hsa046600.51065279
158Insulin secretion_Homo sapiens_hsa049110.50097529
159SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50085447
160FoxO signaling pathway_Homo sapiens_hsa040680.49654901
161Glutathione metabolism_Homo sapiens_hsa004800.48563185
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48227327
163Autoimmune thyroid disease_Homo sapiens_hsa053200.47602378
164RNA transport_Homo sapiens_hsa030130.47319181
165Mineral absorption_Homo sapiens_hsa049780.47251199
166Protein digestion and absorption_Homo sapiens_hsa049740.47096419
167Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47015958
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45735450
169Folate biosynthesis_Homo sapiens_hsa007900.45604759
170Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45198135
171Endocytosis_Homo sapiens_hsa041440.44505248
172Renal cell carcinoma_Homo sapiens_hsa052110.44017349
173Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43990079
174Galactose metabolism_Homo sapiens_hsa000520.43087717
175mTOR signaling pathway_Homo sapiens_hsa041500.42926333
176MicroRNAs in cancer_Homo sapiens_hsa052060.42385699
177Platelet activation_Homo sapiens_hsa046110.40613156
178Focal adhesion_Homo sapiens_hsa045100.39254572
179Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39052341
180AMPK signaling pathway_Homo sapiens_hsa041520.37883120
181Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36365068
182Complement and coagulation cascades_Homo sapiens_hsa046100.35249246
183Estrogen signaling pathway_Homo sapiens_hsa049150.35199362

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