SOWAHD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin biosynthetic process (GO:0042362)8.57610452
2cytidine metabolic process (GO:0046087)8.32261172
3cytidine catabolic process (GO:0006216)8.32261172
4cytidine deamination (GO:0009972)8.32261172
5cell wall macromolecule catabolic process (GO:0016998)7.35411005
6cell wall macromolecule metabolic process (GO:0044036)7.35411005
7pyrimidine ribonucleoside catabolic process (GO:0046133)7.09477716
8diol metabolic process (GO:0034311)6.68467081
9sphingoid metabolic process (GO:0046519)6.45532895
10sphingosine metabolic process (GO:0006670)6.26682913
11cellular extravasation (GO:0045123)5.75417622
12neutrophil activation involved in immune response (GO:0002283)5.71454494
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.63788736
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.63788736
15modulation by symbiont of host immune response (GO:0052553)5.63788736
16positive regulation by symbiont of host defense response (GO:0052509)5.63788736
17modulation by symbiont of host defense response (GO:0052031)5.63788736
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.63788736
19response to peptidoglycan (GO:0032494)5.51009675
20auditory receptor cell differentiation (GO:0042491)5.49893330
21positive regulation of gamma-delta T cell activation (GO:0046645)5.43513283
22ether lipid metabolic process (GO:0046485)5.43197744
23post-embryonic morphogenesis (GO:0009886)5.41181645
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.39982404
25negative regulation of cell killing (GO:0031342)5.39982404
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.37085905
27membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.25382173
28regulation of double-strand break repair via homologous recombination (GO:0010569)5.04924048
29antigen processing and presentation of endogenous antigen (GO:0019883)5.01790678
30mesonephros development (GO:0001823)4.93771595
31regulation of respiratory burst (GO:0060263)4.88605595
32immunoglobulin mediated immune response (GO:0016064)4.86169486
33negative regulation of glial cell proliferation (GO:0060253)4.83081338
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79765991
35macrophage activation involved in immune response (GO:0002281)4.74316883
36regulation of gene expression by genetic imprinting (GO:0006349)4.69700729
37regulation of B cell receptor signaling pathway (GO:0050855)4.62913316
38membrane repolarization during action potential (GO:0086011)4.59172051
39positive regulation of digestive system process (GO:0060456)4.58927137
40keratinocyte proliferation (GO:0043616)4.49399383
41negative regulation of interleukin-12 production (GO:0032695)4.47708944
42translational termination (GO:0006415)4.41111309
43respiratory burst (GO:0045730)4.39213360
44atrial cardiac muscle cell action potential (GO:0086014)4.37660481
45kinetochore organization (GO:0051383)4.35556281
46detection of external biotic stimulus (GO:0098581)4.34308548
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32671406
48ribosomal small subunit assembly (GO:0000028)4.31663293
49regulation of development, heterochronic (GO:0040034)4.29867965
50leukocyte aggregation (GO:0070486)4.29788464
51cranial nerve morphogenesis (GO:0021602)4.27198317
52inner ear receptor cell development (GO:0060119)4.23405340
53regulation of mast cell degranulation (GO:0043304)4.17070990
54polyol biosynthetic process (GO:0046173)4.16356460
55detection of bacterium (GO:0016045)4.16096057
56cardiovascular system development (GO:0072358)4.14974140
57neutrophil activation (GO:0042119)4.08438721
58regulation of hydrogen peroxide metabolic process (GO:0010310)3.99986264
59viral transcription (GO:0019083)3.99558914
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98897762
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.98417621
62leukocyte migration involved in inflammatory response (GO:0002523)3.97563424
63positive regulation of antigen processing and presentation (GO:0002579)3.95815847
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.95463369
65response to host immune response (GO:0052572)3.95463369
66B cell receptor signaling pathway (GO:0050853)3.89890897
67defense response to fungus (GO:0050832)3.88243203
68detection of molecule of bacterial origin (GO:0032490)3.87921641
69regulation of interferon-beta biosynthetic process (GO:0045357)3.87918233
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.84095517
71regulation of leukocyte degranulation (GO:0043300)3.83567937
72vitamin D metabolic process (GO:0042359)3.83062895
73positive regulation of respiratory burst (GO:0060267)3.81963304
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81728524
75myeloid cell activation involved in immune response (GO:0002275)3.81199029
76potassium ion export (GO:0071435)3.80986337
77granulocyte activation (GO:0036230)3.80751063
78regulation of mast cell activation involved in immune response (GO:0033006)3.80469242
79detection of biotic stimulus (GO:0009595)3.79280019
80B cell mediated immunity (GO:0019724)3.78037483
81positive regulation of interleukin-8 secretion (GO:2000484)3.73873384
82regulation of gamma-delta T cell activation (GO:0046643)3.73777049
83germ cell migration (GO:0008354)3.73477753
84positive regulation of mast cell activation (GO:0033005)3.73372764
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71971314
86cellular response to epinephrine stimulus (GO:0071872)3.71892741
87replicative senescence (GO:0090399)3.71003016
88nucleoside salvage (GO:0043174)3.70605677
89kinetochore assembly (GO:0051382)3.66455975
90defense response to protozoan (GO:0042832)3.65860367
91pyrimidine nucleoside catabolic process (GO:0046135)3.63744755
92pyrimidine-containing compound salvage (GO:0008655)3.63263107
93pyrimidine nucleoside salvage (GO:0043097)3.63263107
94regulation of vitamin metabolic process (GO:0030656)3.63177736
95genetic imprinting (GO:0071514)3.62310314
96positive regulation of B cell differentiation (GO:0045579)3.62038656
97negative regulation of epidermal cell differentiation (GO:0045605)3.61105635
98desmosome organization (GO:0002934)3.60946069
99urogenital system development (GO:0001655)3.60649426
100microglial cell activation (GO:0001774)3.60244984
101response to host (GO:0075136)3.58224345
102response to host defenses (GO:0052200)3.58224345
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.58224345
104production of molecular mediator involved in inflammatory response (GO:0002532)3.57238414
105cellular ketone body metabolic process (GO:0046950)3.57056993
106detection of other organism (GO:0098543)3.56919742
107positive regulation of endothelial cell apoptotic process (GO:2000353)3.56020253
108regulation of mast cell activation (GO:0033003)3.51078878
109response to muramyl dipeptide (GO:0032495)3.48729984
110negative regulation of lymphocyte mediated immunity (GO:0002707)3.48646277
111neutrophil mediated immunity (GO:0002446)3.46186187
112regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.42579390
113glycerol ether metabolic process (GO:0006662)3.42356136
114macrophage activation (GO:0042116)3.42080680
115negative regulation of erythrocyte differentiation (GO:0045647)3.41995012
116regulation of B cell differentiation (GO:0045577)3.39957645
117radial glial cell differentiation (GO:0060019)3.36654903
118ventricular cardiac muscle cell action potential (GO:0086005)3.36545274
119regulation of axon extension involved in axon guidance (GO:0048841)3.36339106
120membrane repolarization (GO:0086009)3.35794920
121negative regulation of leukocyte mediated immunity (GO:0002704)3.35513559
122regulation of T-helper 2 cell differentiation (GO:0045628)3.33335419
123negative regulation of phagocytosis (GO:0050765)3.33021521
124positive regulation of mast cell activation involved in immune response (GO:0033008)3.32742862
125positive regulation of mast cell degranulation (GO:0043306)3.32742862
126cellular protein complex disassembly (GO:0043624)3.32208498
127interferon-gamma-mediated signaling pathway (GO:0060333)3.30665132
128negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30056087
129response to protozoan (GO:0001562)3.29742203
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24989663
131leukocyte degranulation (GO:0043299)3.24693838
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.24459948
133regulation of regulated secretory pathway (GO:1903305)3.24127556
134sulfation (GO:0051923)3.22929829
135regulation of gamma-delta T cell differentiation (GO:0045586)3.22043465
136inner ear receptor cell differentiation (GO:0060113)3.20884622
137type I interferon signaling pathway (GO:0060337)3.19557824
138cellular response to type I interferon (GO:0071357)3.19557824
139DNA topological change (GO:0006265)3.18317935
140response to type I interferon (GO:0034340)3.16050829
141hair cell differentiation (GO:0035315)3.15583291
142viral life cycle (GO:0019058)3.13205985
143neural crest cell development (GO:0014032)3.11468396
144regulation of heart rate by cardiac conduction (GO:0086091)3.09725327
145response to interleukin-15 (GO:0070672)3.09066640
146ether metabolic process (GO:0018904)3.08796885
147regulation of antigen processing and presentation (GO:0002577)3.08343987
148regulation of axon guidance (GO:1902667)3.08259443
149glomerular basement membrane development (GO:0032836)3.07773741
150positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04555531
151positive thymic T cell selection (GO:0045059)3.02919108
152disruption of cells of other organism (GO:0044364)3.02108829
153killing of cells of other organism (GO:0031640)3.02108829
154negative regulation of interleukin-6 production (GO:0032715)3.01531239
155myeloid leukocyte mediated immunity (GO:0002444)3.00901171
156positive regulation of interferon-alpha production (GO:0032727)2.99882274
157antigen processing and presentation via MHC class Ib (GO:0002475)2.99342146
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98680854
159NIK/NF-kappaB signaling (GO:0038061)2.98652716
160heterochromatin organization (GO:0070828)2.97430575
161germinal center formation (GO:0002467)2.96425567
162negative regulation of innate immune response (GO:0045824)2.96244241
163negative regulation of epidermis development (GO:0045683)2.96211037
164ketone body metabolic process (GO:1902224)2.96156250
165regulation of cardioblast proliferation (GO:0003264)2.95345289
166regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95345289
167regulation of histone H3-K27 methylation (GO:0061085)2.94173731
168regulation of double-strand break repair (GO:2000779)2.93435148
169regulation of tolerance induction (GO:0002643)2.92583004
170sphingomyelin metabolic process (GO:0006684)2.91143857
171regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90888838
172regulation of protein dephosphorylation (GO:0035304)2.90728227
173positive regulation of potassium ion transmembrane transport (GO:1901381)2.88709973
174regulation of T cell tolerance induction (GO:0002664)2.88323514
175regulation of superoxide anion generation (GO:0032928)2.88257059
176granulocyte differentiation (GO:0030851)2.87360094
177positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86455644
178regulation of glial cell proliferation (GO:0060251)2.85601087
179glomerular visceral epithelial cell development (GO:0072015)2.85034036
180myeloid leukocyte activation (GO:0002274)2.84929226
181translational elongation (GO:0006414)2.84189129
182negative regulation of cytokine production involved in immune response (GO:0002719)2.83918442
183ribosomal small subunit biogenesis (GO:0042274)2.83723249
184cell morphogenesis involved in neuron differentiation (GO:0048667)2.82941063
185amino sugar catabolic process (GO:0046348)2.82479783
186positive regulation of type 2 immune response (GO:0002830)2.81089255
187negative regulation of T cell mediated immunity (GO:0002710)2.80726218
188SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80215482
189positive regulation of protein dephosphorylation (GO:0035307)2.80174375
190long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.78921806
191negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78041278
192negative regulation of T-helper cell differentiation (GO:0045623)2.78041278
193cotranslational protein targeting to membrane (GO:0006613)2.77093517
194vitamin biosynthetic process (GO:0009110)2.76258066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.56188953
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.75976240
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.75571151
4E2F7_22180533_ChIP-Seq_HELA_Human4.00419884
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.85962806
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.77253302
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77021676
8VDR_21846776_ChIP-Seq_THP-1_Human3.68364713
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41325520
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.37454036
11MYC_22102868_ChIP-Seq_BL_Human3.05314192
12VDR_24763502_ChIP-Seq_THP-1_Human2.99871826
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96565549
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87965973
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.83258364
16SPI1_23547873_ChIP-Seq_NB4_Human2.80480145
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.71044006
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68127936
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64823133
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.56575822
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49316956
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48516187
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42399434
24SPI1_23127762_ChIP-Seq_K562_Human2.35657071
25MAF_26560356_Chip-Seq_TH1_Human2.33713369
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31652557
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31356590
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.29449724
29UTX_26944678_Chip-Seq_JUKART_Human2.20949637
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19419651
31SCL_19346495_ChIP-Seq_HPC-7_Human2.19032551
32ZNF274_21170338_ChIP-Seq_K562_Hela2.10339416
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10275324
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10086260
35EGR1_19374776_ChIP-ChIP_THP-1_Human2.06354100
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06056052
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04217790
38STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00931624
39EZH2_22144423_ChIP-Seq_EOC_Human10.1295893
40TCF7_22412390_ChIP-Seq_EML_Mouse1.94627580
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91341047
42MYB_26560356_Chip-Seq_TH2_Human1.90452109
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89224702
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87312398
45LXR_22292898_ChIP-Seq_THP-1_Human1.84429514
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84020201
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82673371
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82190316
49KDM2B_26808549_Chip-Seq_DND41_Human1.81596643
50MYB_26560356_Chip-Seq_TH1_Human1.80103298
51MAF_26560356_Chip-Seq_TH2_Human1.79730514
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78352377
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76911817
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72496530
55RUNX_20019798_ChIP-Seq_JUKART_Human1.72069875
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72044614
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65824248
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.65378051
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63185721
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62974393
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59198807
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56924562
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55293204
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53325270
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53322084
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52641084
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51715187
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.51642857
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50660721
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47727869
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45984293
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45652447
73DROSHA_22980978_ChIP-Seq_HELA_Human1.45528608
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44513244
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44347324
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42519190
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41985355
78VDR_24787735_ChIP-Seq_THP-1_Human1.41633444
79AR_21909140_ChIP-Seq_LNCAP_Human1.38660457
80BCL6_27268052_Chip-Seq_Bcells_Human1.36158574
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34303274
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33123637
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33123637
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32815634
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31219179
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30717641
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30634504
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30326866
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29757995
90BCOR_27268052_Chip-Seq_Bcells_Human1.29554217
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29280591
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.28393600
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.28334921
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27501452
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25407611
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24932476
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24932476
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24533981
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24215707
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23583308
101GATA3_27048872_Chip-Seq_THYMUS_Human1.23233214
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21910552
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.21770910
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18422582
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17806096
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.17496330
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16397171
108PU_27001747_Chip-Seq_BMDM_Mouse1.15545597
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14474759
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14292286
111AHR_22903824_ChIP-Seq_MCF-7_Human1.12713760
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.12667372
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11919758
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11410976
115NCOR1_26117541_ChIP-Seq_K562_Human1.10723237
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09424591
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.09114530
118CIITA_25753668_ChIP-Seq_RAJI_Human1.09016827
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.08017049
120RNF2_27304074_Chip-Seq_NSC_Mouse1.06543981
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06515019
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.06498672
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05882960
124P68_20966046_ChIP-Seq_HELA_Human1.04975847
125RACK7_27058665_Chip-Seq_MCF-7_Human1.04320925
126GATA1_19941826_ChIP-Seq_K562_Human1.02613742
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02171787
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02003957
129RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01915941
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.01466192
131KLF5_25053715_ChIP-Seq_YYC3_Human1.00227358
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99929081
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.99112830
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99099773
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98325115
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98048162
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.97487634
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96948610
139GATA4_25053715_ChIP-Seq_YYC3_Human0.95985754
140TFEB_21752829_ChIP-Seq_HELA_Human0.95737731
141GATA1_22025678_ChIP-Seq_K562_Human0.94938034
142SPI1_20517297_ChIP-Seq_HL60_Human0.92363351
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92286678
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91444729
145SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91413177
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90440000
147TP53_18474530_ChIP-ChIP_U2OS_Human0.89528088
148CTCF_26484167_Chip-Seq_Bcells_Mouse0.89189132
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86774280
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85336776
151E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84977104
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84588273
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84318947
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83030411
155NFE2_27457419_Chip-Seq_LIVER_Mouse0.82677541
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82409668
157ZNF263_19887448_ChIP-Seq_K562_Human0.81558892
158RNF2_27304074_Chip-Seq_ESCs_Mouse0.78716524
159EZH2_27294783_Chip-Seq_NPCs_Mouse0.78310198
160SOX2_20726797_ChIP-Seq_SW620_Human0.78136798
161OCT4_18555785_Chip-Seq_ESCs_Mouse0.77616425
162SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77489827
163NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76908293
164ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76818797
165CDX2_22108803_ChIP-Seq_LS180_Human0.76416380
166GF1_26923725_Chip-Seq_HPCs_Mouse0.76306442
167P53_22387025_ChIP-Seq_ESCs_Mouse0.75791632
168FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75300479
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.75191656
170CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74421750
171SUZ12_27294783_Chip-Seq_ESCs_Mouse0.72655949
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.72455439
173PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72329667
174LXR_22158963_ChIP-Seq_LIVER_Mouse0.72155429
175PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.71885824
176ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70804509
177SOX11_22085726_ChIP-Seq_ESNs_Mouse0.70193578
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.69914774
179IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69210586
180TCF4_22108803_ChIP-Seq_LS180_Human0.68302371
181RXR_22158963_ChIP-Seq_LIVER_Mouse0.67926169
182PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67902260
183PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67847904
184ER_23166858_ChIP-Seq_MCF-7_Human0.67474911
185NMYC_18555785_Chip-Seq_ESCs_Mouse0.66880271
186ETV2_25802403_ChIP-Seq_MESCs_Mouse0.66526829
187GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.66244988
188CBP_21632823_ChIP-Seq_H3396_Human0.66007217
189PU1_27457419_Chip-Seq_LIVER_Mouse0.65761741
190SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65747082
191SUZ12_18555785_Chip-Seq_ESCs_Mouse0.65746059
192SOX9_24532713_ChIP-Seq_HFSC_Mouse0.65583341
193MYC_19829295_ChIP-Seq_ESCs_Human0.65481696
194ESR1_21235772_ChIP-Seq_MCF-7_Human0.65333849
195ZFX_18555785_Chip-Seq_ESCs_Mouse0.65191292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.00961426
2MP0008004_abnormal_stomach_pH6.06609243
3MP0001835_abnormal_antigen_presentation3.88023457
4MP0003724_increased_susceptibility_to3.82337316
5MP0003123_paternal_imprinting3.66202033
6MP0009278_abnormal_bone_marrow3.50206178
7MP0003303_peritoneal_inflammation3.45607619
8MP0003787_abnormal_imprinting3.39834881
9MP0002419_abnormal_innate_immunity3.24193234
10MP0000685_abnormal_immune_system3.07078891
11MP0005387_immune_system_phenotype2.95309294
12MP0001790_abnormal_immune_system2.95309294
13MP0005025_abnormal_response_to2.94467305
14MP0001800_abnormal_humoral_immune2.86401652
15MP0005671_abnormal_response_to2.85990455
16MP0005000_abnormal_immune_tolerance2.80931504
17MP0009785_altered_susceptibility_to2.69526179
18MP0002452_abnormal_antigen_presenting2.61619305
19MP0002723_abnormal_immune_serum2.59141987
20MP0005083_abnormal_biliary_tract2.59030087
21MP0002796_impaired_skin_barrier2.57176573
22MP0002420_abnormal_adaptive_immunity2.55763669
23MP0001819_abnormal_immune_cell2.53326520
24MP0002132_abnormal_respiratory_system2.52411725
25MP0006082_CNS_inflammation2.47777475
26MP0003300_gastrointestinal_ulcer2.43983697
27MP0002736_abnormal_nociception_after2.43020443
28MP0005058_abnormal_lysosome_morphology2.42145099
29MP0002148_abnormal_hypersensitivity_rea2.35082754
30MP0003172_abnormal_lysosome_physiology2.31465288
31MP0005464_abnormal_platelet_physiology2.27844192
32MP0005623_abnormal_meninges_morphology2.24671415
33MP0008260_abnormal_autophagy2.19406891
34MP0005084_abnormal_gallbladder_morpholo2.17605833
35MP0001485_abnormal_pinna_reflex2.16082809
36MP0002139_abnormal_hepatobiliary_system2.14196383
37MP0002928_abnormal_bile_duct2.13682132
38MP0005501_abnormal_skin_physiology2.05510995
39MP0005085_abnormal_gallbladder_physiolo2.03076621
40MP0001533_abnormal_skeleton_physiology2.02129390
41MP0003941_abnormal_skin_development2.00479077
42MP0003950_abnormal_plasma_membrane1.99048025
43MP0002396_abnormal_hematopoietic_system1.96642895
44MP0002398_abnormal_bone_marrow1.96004506
45MP0003763_abnormal_thymus_physiology1.95524533
46MP0002405_respiratory_system_inflammati1.94413511
47MP0000716_abnormal_immune_system1.93303645
48MP0004272_abnormal_basement_membrane1.84061572
49MP0009333_abnormal_splenocyte_physiolog1.78707345
50MP0001663_abnormal_digestive_system1.78459475
51MP0001845_abnormal_inflammatory_respons1.77845549
52MP0001968_abnormal_touch/_nociception1.75103671
53MP0000689_abnormal_spleen_morphology1.70977533
54MP0003121_genomic_imprinting1.70300793
55MP0005365_abnormal_bile_salt1.69257480
56MP0000566_synostosis1.64464472
57MP0002722_abnormal_immune_system1.61967217
58MP0002429_abnormal_blood_cell1.59511273
59MP0005381_digestive/alimentary_phenotyp1.59434910
60MP0005310_abnormal_salivary_gland1.57885933
61MP0008469_abnormal_protein_level1.55040231
62MP0005410_abnormal_fertilization1.53303879
63MP0005451_abnormal_body_composition1.52671463
64MP0004742_abnormal_vestibular_system1.51429856
65MP0000858_altered_metastatic_potential1.51397837
66MP0003075_altered_response_to1.51009397
67MP0000462_abnormal_digestive_system1.50836340
68MP0004947_skin_inflammation1.49139492
69MP0000465_gastrointestinal_hemorrhage1.43598986
70MP0003866_abnormal_defecation1.41784225
71MP0008872_abnormal_physiological_respon1.41435795
72MP0003111_abnormal_nucleus_morphology1.40765367
73MP0009840_abnormal_foam_cell1.37168106
74MP0003806_abnormal_nucleotide_metabolis1.33300250
75MP0000703_abnormal_thymus_morphology1.33031623
76MP0000537_abnormal_urethra_morphology1.32183817
77MP0001756_abnormal_urination1.31751067
78MP0005171_absent_coat_pigmentation1.30475896
79MP0010094_abnormal_chromosome_stability1.29050081
80MP0008995_early_reproductive_senescence1.29015765
81MP0002163_abnormal_gland_morphology1.26542574
82MP0009764_decreased_sensitivity_to1.26145851
83MP0001545_abnormal_hematopoietic_system1.25886847
84MP0005397_hematopoietic_system_phenotyp1.25886847
85MP0001873_stomach_inflammation1.24980585
86MP0003183_abnormal_peptide_metabolism1.24895301
87MP0000470_abnormal_stomach_morphology1.23540175
88MP0002277_abnormal_respiratory_mucosa1.23070406
89MP0002998_abnormal_bone_remodeling1.22284515
90MP0003705_abnormal_hypodermis_morpholog1.22141183
91MP0000343_altered_response_to1.22094077
92MP0000613_abnormal_salivary_gland1.22070966
93MP0000604_amyloidosis1.17073053
94MP0003315_abnormal_perineum_morphology1.16845171
95MP0001853_heart_inflammation1.15497097
96MP0001188_hyperpigmentation1.13163673
97MP0004883_abnormal_blood_vessel1.11081536
98MP0010771_integument_phenotype1.10039568
99MP0004510_myositis1.09426305
100MP0003385_abnormal_body_wall1.09296695
101MP0003890_abnormal_embryonic-extraembry1.06851417
102MP0002102_abnormal_ear_morphology1.06847857
103MP0001851_eye_inflammation1.05781969
104MP0002098_abnormal_vibrissa_morphology1.03327006
105MP0003938_abnormal_ear_development1.02780933
106MP0002138_abnormal_hepatobiliary_system1.02367192
107MP0005166_decreased_susceptibility_to1.00510081
108MP0003077_abnormal_cell_cycle0.99704917
109MP0002249_abnormal_larynx_morphology0.99407571
110MP0002166_altered_tumor_susceptibility0.99376178
111MP0003690_abnormal_glial_cell0.99350379
112MP0005076_abnormal_cell_differentiation0.96542653
113MP0003566_abnormal_cell_adhesion0.95777919
114MP0008007_abnormal_cellular_replicative0.93636887
115MP0003137_abnormal_impulse_conducting0.92451607
116MP0003119_abnormal_digestive_system0.92113420
117MP0003693_abnormal_embryo_hatching0.91599749
118MP0002127_abnormal_cardiovascular_syste0.88866716
119MP0002254_reproductive_system_inflammat0.88726253
120MP0003448_altered_tumor_morphology0.88083757
121MP0009763_increased_sensitivity_to0.87076167
122MP0003191_abnormal_cellular_cholesterol0.86555768
123MP0001286_abnormal_eye_development0.86498969
124MP0003828_pulmonary_edema0.86167223
125MP0005388_respiratory_system_phenotype0.85995780
126MP0002133_abnormal_respiratory_system0.85995780
127MP0005164_abnormal_response_to0.84935200
128MP0004957_abnormal_blastocyst_morpholog0.84071030
129MP0003453_abnormal_keratinocyte_physiol0.83491732
130MP0003942_abnormal_urinary_system0.83149442
131MP0000490_abnormal_crypts_of0.81985725
132MP0004808_abnormal_hematopoietic_stem0.81816434
133MP0005075_abnormal_melanosome_morpholog0.80573455
134MP0002092_abnormal_eye_morphology0.80349339
135MP0004484_altered_response_of0.79694090
136MP0003091_abnormal_cell_migration0.78840791
137MP0005390_skeleton_phenotype0.78465034
138MP0001346_abnormal_lacrimal_gland0.77845878
139MP0000383_abnormal_hair_follicle0.74505723
140MP0000026_abnormal_inner_ear0.73255409
141MP0009384_cardiac_valve_regurgitation0.73179690
142MP0009053_abnormal_anal_canal0.73088357
143MP0002090_abnormal_vision0.71576552
144MP0000015_abnormal_ear_pigmentation0.68496275
145MP0004381_abnormal_hair_follicle0.68353618
146MP0005379_endocrine/exocrine_gland_phen0.67232036
147MP0001216_abnormal_epidermal_layer0.66140328
148MP0005319_abnormal_enzyme/_coenzyme0.64673741
149MP0003795_abnormal_bone_structure0.64628926
150MP0003436_decreased_susceptibility_to0.64339229
151MP0010678_abnormal_skin_adnexa0.64334353
152MP0004185_abnormal_adipocyte_glucose0.63363897
153MP0002019_abnormal_tumor_incidence0.62570335
154MP0008874_decreased_physiological_sensi0.62442557
155MP0002697_abnormal_eye_size0.62128347
156MP0009765_abnormal_xenobiotic_induced0.61335525
157MP0010155_abnormal_intestine_physiology0.61269555
158MP0008932_abnormal_embryonic_tissue0.60506273
159MP0000249_abnormal_blood_vessel0.60113722
160MP0002735_abnormal_chemical_nociception0.59373616
161MP0003656_abnormal_erythrocyte_physiolo0.59266558
162MP0002009_preneoplasia0.57751760
163MP0009780_abnormal_chondrocyte_physiolo0.57584352
164MP0008877_abnormal_DNA_methylation0.56793941
165MP0000350_abnormal_cell_proliferation0.56122796
166MP0003221_abnormal_cardiomyocyte_apopto0.56104804
167MP0003698_abnormal_male_reproductive0.55671428
168MP0002295_abnormal_pulmonary_circulatio0.55556578
169MP0001963_abnormal_hearing_physiology0.54735963
170MP0008875_abnormal_xenobiotic_pharmacok0.54686811
171MP0000609_abnormal_liver_physiology0.54027385
172MP0001986_abnormal_taste_sensitivity0.53864167
173MP0000678_abnormal_parathyroid_gland0.53837501
174MP0004197_abnormal_fetal_growth/weight/0.53188385
175MP0010352_gastrointestinal_tract_polyps0.51873650
176MP0002933_joint_inflammation0.50908592
177MP0002006_tumorigenesis0.47955031
178MP0003329_amyloid_beta_deposits0.47296332
179MP0003045_fibrosis0.45595488
180MP0000313_abnormal_cell_death0.45376360

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.70703470
2Recurrent abscess formation (HP:0002722)6.33912770
3Recurrent bacterial skin infections (HP:0005406)6.13410936
4Abnormality of macrophages (HP:0004311)5.75167387
5Thin bony cortex (HP:0002753)5.69081768
6Recurrent gram-negative bacterial infections (HP:0005420)5.22429323
7Abnormal EKG (HP:0003115)5.14774091
8Prolonged QT interval (HP:0001657)4.91291491
9Colon cancer (HP:0003003)4.86872886
10Ileus (HP:0002595)4.80676495
11Myositis (HP:0100614)4.72378370
12Mediastinal lymphadenopathy (HP:0100721)4.49413280
13Abnormal hemoglobin (HP:0011902)4.47601652
14Widely patent fontanelles and sutures (HP:0004492)4.37372176
15Congenital sensorineural hearing impairment (HP:0008527)4.36019395
16Oligodactyly (hands) (HP:0001180)4.34515223
17Chronic obstructive pulmonary disease (HP:0006510)4.33167329
18Obstructive lung disease (HP:0006536)4.33167329
19Recurrent fungal infections (HP:0002841)4.30978234
20Delayed epiphyseal ossification (HP:0002663)4.23893899
21Meningitis (HP:0001287)4.20907982
22Recurrent skin infections (HP:0001581)4.15652709
23Orchitis (HP:0100796)4.12636503
24Stomatitis (HP:0010280)4.05849203
25Oligodactyly (HP:0012165)4.03766438
26Cellulitis (HP:0100658)3.95075854
27Enlarged epiphyses (HP:0010580)3.94526844
28Elevated erythrocyte sedimentation rate (HP:0003565)3.91609231
29Chronic mucocutaneous candidiasis (HP:0002728)3.90815575
30Recurrent cutaneous fungal infections (HP:0011370)3.90815575
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.85191905
32Abnormality of liposaccharide metabolism (HP:0010968)3.82425914
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.82425914
34Abnormality of glycolipid metabolism (HP:0010969)3.82425914
35Optic neuritis (HP:0100653)3.65516552
36Retrobulbar optic neuritis (HP:0100654)3.65516552
37Reticulocytopenia (HP:0001896)3.52813670
38Ventricular arrhythmia (HP:0004308)3.50184046
39Urticaria (HP:0001025)3.48711916
40Spontaneous hematomas (HP:0007420)3.48027797
41Gingivitis (HP:0000230)3.48014385
42Increased IgE level (HP:0003212)3.43568348
43Ankle contracture (HP:0006466)3.42958764
44Encephalitis (HP:0002383)3.40670873
45Absent thumb (HP:0009777)3.34187235
46Gastrointestinal infarctions (HP:0005244)3.33701929
47Abnormality of the costochondral junction (HP:0000919)3.31523988
48Flat occiput (HP:0005469)3.29193542
49Recurrent viral infections (HP:0004429)3.27586392
50Petechiae (HP:0000967)3.26825288
51Agammaglobulinemia (HP:0004432)3.23421372
52Axonal loss (HP:0003447)3.16307013
53Hypoglycemic coma (HP:0001325)3.15116367
54Prolonged bleeding time (HP:0003010)3.15007479
55Increased cerebral lipofuscin (HP:0011813)3.11705108
56Vasculitis (HP:0002633)3.11597441
57Panhypogammaglobulinemia (HP:0003139)3.09538067
58Unilateral renal agenesis (HP:0000122)3.08994386
59Rectal prolapse (HP:0002035)3.07787978
60Hypochromic microcytic anemia (HP:0004840)3.05660364
61Gastrointestinal inflammation (HP:0004386)3.02661233
62Inflammation of the large intestine (HP:0002037)2.95315939
63Osteomyelitis (HP:0002754)2.94166962
64Colitis (HP:0002583)2.89178438
65Supernumerary ribs (HP:0005815)2.85982640
66Hypochromic anemia (HP:0001931)2.84808954
67Purpura (HP:0000979)2.84507911
68Wide cranial sutures (HP:0010537)2.81088440
69Enlarged penis (HP:0000040)2.80145113
70Systemic lupus erythematosus (HP:0002725)2.79166120
71Right ventricular cardiomyopathy (HP:0011663)2.78107506
72Pustule (HP:0200039)2.74039559
73Amyloidosis (HP:0011034)2.72694513
74Chest pain (HP:0100749)2.71485645
75Loss of speech (HP:0002371)2.70693417
76Male infertility (HP:0003251)2.69650176
7711 pairs of ribs (HP:0000878)2.66391890
78Abnormal spermatogenesis (HP:0008669)2.65869924
79Pulmonary infiltrates (HP:0002113)2.64390110
80Keratoconjunctivitis sicca (HP:0001097)2.64352588
81Epistaxis (HP:0000421)2.63831209
82Hepatosplenomegaly (HP:0001433)2.63702582
83Tibial bowing (HP:0002982)2.62846146
84Episodic fever (HP:0001954)2.61179041
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.58378041
86Abnormal trabecular bone morphology (HP:0100671)2.55433620
87Gastrointestinal stroma tumor (HP:0100723)2.55038012
88Gingival bleeding (HP:0000225)2.53872024
89Poor head control (HP:0002421)2.53155087
90Keratoconjunctivitis (HP:0001096)2.51953762
91Vacuolated lymphocytes (HP:0001922)2.48680412
92Recurrent pneumonia (HP:0006532)2.47371044
93Hemoptysis (HP:0002105)2.45835922
94Short tibia (HP:0005736)2.44224539
95Syncope (HP:0001279)2.43910778
96Sepsis (HP:0100806)2.41481840
97Lymphopenia (HP:0001888)2.41019215
98Azoospermia (HP:0000027)2.40392196
99Abnormality of the axillary hair (HP:0100134)2.39983476
100Abnormality of secondary sexual hair (HP:0009888)2.39983476
101Increased serum ferritin (HP:0003281)2.38192504
102Dysostosis multiplex (HP:0000943)2.37939193
103Increased IgM level (HP:0003496)2.37255323
104Supernumerary bones of the axial skeleton (HP:0009144)2.36555756
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36024009
106Pallor (HP:0000980)2.35177669
107Macrocytic anemia (HP:0001972)2.33912088
108Recurrent lower respiratory tract infections (HP:0002783)2.32769808
109Premature loss of primary teeth (HP:0006323)2.31832781
110Parakeratosis (HP:0001036)2.31440140
111Abnormality of cells of the erythroid lineage (HP:0012130)2.28671516
112Myopathic facies (HP:0002058)2.27489051
113Abnormality of chloride homeostasis (HP:0011422)2.25654905
114Abnormal number of erythroid precursors (HP:0012131)2.24240002
115Viral hepatitis (HP:0006562)2.24005471
116Renal cortical cysts (HP:0000803)2.23863731
117Anorexia (HP:0002039)2.23621223
118Abnormality of T cells (HP:0002843)2.23388976
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.23153614
120Abnormality of T cell physiology (HP:0011840)2.22900237
121Abnormality of cells of the lymphoid lineage (HP:0012140)2.21921781
122Recurrent sinusitis (HP:0011108)2.21113797
123Hypoplasia of the pons (HP:0012110)2.20609244
124Trismus (HP:0000211)2.19853308
125Hypergammaglobulinemia (HP:0010702)2.18940561
126Abnormality of the pons (HP:0007361)2.17809557
127Abnormality of iron homeostasis (HP:0011031)2.17727161
128Fibular hypoplasia (HP:0003038)2.17692500
129Ridged nail (HP:0001807)2.17488178
130Pulmonary embolism (HP:0002204)2.17353711
131Microcytic anemia (HP:0001935)2.16674430
132Leukocytosis (HP:0001974)2.16386015
133IgA deficiency (HP:0002720)2.15599503
134Congenital, generalized hypertrichosis (HP:0004540)2.14541949
135Skin ulcer (HP:0200042)2.12578827
136T lymphocytopenia (HP:0005403)2.11617840
137Arterial thrombosis (HP:0004420)2.09334413
138Upper motor neuron abnormality (HP:0002127)2.09295054
139Generalized aminoaciduria (HP:0002909)2.08896099
140Anhidrosis (HP:0000970)2.08167972
141Abnormality of the peritoneum (HP:0002585)2.07471045
142Granulocytopenia (HP:0001913)2.05544343
143IgM deficiency (HP:0002850)2.04927819
144Duplicated collecting system (HP:0000081)2.04192655
145Restrictive lung disease (HP:0002091)2.03771737
146Metaphyseal irregularity (HP:0003025)2.03567229
147Hepatic necrosis (HP:0002605)2.02654744
148Biliary tract neoplasm (HP:0100574)2.00206614
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00166019
150Proximal tubulopathy (HP:0000114)2.00103283
151Ventricular fibrillation (HP:0001663)11.8857026
152Abnormal umbilical cord blood vessels (HP:0011403)1.99536600
153Single umbilical artery (HP:0001195)1.99536600
154Abnormality of the fetal cardiovascular system (HP:0010948)1.99536600
155Skin rash (HP:0000988)1.98888758
156Abnormality of the pleura (HP:0002103)1.97458434
157Abnormal platelet volume (HP:0011876)1.97383057
158Abnormality of T cell number (HP:0011839)1.97053216
159Supernumerary spleens (HP:0009799)1.95785937
160Microvesicular hepatic steatosis (HP:0001414)1.94958331
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94427330
162Abnormality of polysaccharide metabolism (HP:0011012)1.94427330
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94427330
164Multiple enchondromatosis (HP:0005701)1.93274749
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92007869
166Autoamputation (HP:0001218)1.91322610
167Autoimmune thrombocytopenia (HP:0001973)1.91258812
168Verrucae (HP:0200043)1.90915693
169Papilloma (HP:0012740)1.90915693
170Abnormality of the gastric mucosa (HP:0004295)1.85835927
171Hypertensive crisis (HP:0100735)1.85821639
172Abnormal biliary tract morphology (HP:0012440)1.84680976
173Absent radius (HP:0003974)1.84053592
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82595633
175Ureteral duplication (HP:0000073)1.80672704
176Stage 5 chronic kidney disease (HP:0003774)1.80571839
177Metabolic alkalosis (HP:0200114)1.80546846
178Rickets (HP:0002748)1.80141574
1793-Methylglutaconic aciduria (HP:0003535)1.79112551
180Tachypnea (HP:0002789)1.76045426
181Elfin facies (HP:0004428)1.74869913
182Abnormality of the renal cortex (HP:0011035)1.72783772
183Septo-optic dysplasia (HP:0100842)1.72356521
184Optic nerve coloboma (HP:0000588)1.71251305
185Missing ribs (HP:0000921)1.70918068
186Bicornuate uterus (HP:0000813)1.70745095
187Abnormality of the right ventricle (HP:0001707)1.70638685
188Absent forearm bone (HP:0003953)1.68966913
189Aplasia involving forearm bones (HP:0009822)1.68966913
190Disinhibition (HP:0000734)1.68255006
191Femoral bowing (HP:0002980)1.67161518
192Intellectual disability, profound (HP:0002187)1.65121957
193Muscle stiffness (HP:0003552)1.64721684
194Sparse eyelashes (HP:0000653)1.63793788
195Germ cell neoplasia (HP:0100728)1.61898458
196Woolly hair (HP:0002224)1.61622088
197Thrombocytosis (HP:0001894)1.60410085
198Double outlet right ventricle (HP:0001719)1.60132829
199Congenital malformation of the right heart (HP:0011723)1.60132829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.13775816
2LMTK25.93076576
3FRK4.72886372
4MAP4K13.85668081
5ERN13.43994579
6BLK3.28367932
7IRAK43.20835296
8GRK13.06467152
9INSRR2.99067725
10MAP2K32.86572706
11RPS6KA42.74820065
12DAPK22.53808977
13PBK2.45906732
14PRPF4B2.34905291
15CDK192.33638356
16EPHB22.30721505
17FES2.27260218
18GRK62.14789959
19MAP3K122.04213284
20NLK2.00353514
21CSF1R1.90389831
22TYK21.86974215
23BTK1.85930607
24MAP3K131.81823961
25TAOK11.79466272
26SYK1.76929469
27ZAP701.75067485
28SMG11.72204504
29FGR1.70898326
30KIT1.66099167
31HCK1.61480965
32PRKG21.58792431
33MAP3K111.57852976
34RIPK41.57312964
35MAP3K141.55598453
36PAK41.50389167
37JAK31.49589575
38CDC71.46509439
39LATS21.46213358
40LYN1.44015470
41EPHB11.37647360
42WEE11.33768874
43TBK11.33369560
44TESK21.29799186
45SIK31.28385392
46TESK11.27932472
47MAP3K11.24568436
48TTK1.19546416
49MAP2K21.19365858
50YES11.16579462
51ERBB21.15353573
52JAK21.14136019
53EIF2AK21.11610707
54PKN21.09793799
55KSR21.08205165
56LCK1.05973584
57ALK1.04492593
58ADRBK21.03039107
59LIMK11.01202991
60MATK0.99666491
61PDPK10.99227430
62PDGFRA0.99184661
63TXK0.99025330
64MYLK0.98346872
65PDK10.98259629
66TAOK20.95073739
67MARK30.94524476
68PTK60.93532290
69PRKD20.93279440
70SIK20.92228324
71ABL20.90174979
72CHEK20.85649787
73TGFBR20.83319473
74BRSK20.82489951
75CDK60.81645777
76MAP3K60.81203390
77BCR0.79755274
78IRAK20.79167194
79PKN10.79166304
80RPS6KB20.78955868
81STK100.78878682
82ITK0.78602091
83TAOK30.76427081
84STK390.75402434
85NTRK30.72028422
86MAPK120.71943706
87STK160.71010713
88AURKA0.70918793
89MAP3K100.68737273
90RPS6KL10.67082432
91RPS6KC10.67082432
92CDK40.66781280
93SIK10.66534232
94NME20.64886286
95BCKDK0.64634168
96TLK10.64061682
97CDC42BPA0.62997477
98WNK10.61869522
99MAP3K80.60357055
100PIM20.58808719
101MAP3K50.58708804
102IRAK30.57773583
103MAPK70.57189558
104BMPR20.55429036
105MAP3K90.54268572
106TEC0.54183155
107HIPK20.53819417
108IRAK10.53732523
109MST1R0.53681205
110RPS6KA60.53278631
111TRPM70.52604049
112CSNK1E0.52154129
113OXSR10.50769720
114PRKCG0.50701432
115DYRK1B0.49502937
116IKBKB0.49460667
117MKNK20.49364740
118PRKCQ0.48889682
119CSNK1A1L0.48297960
120PIM10.48250840
121PRKCA0.47838146
122TTN0.47677590
123MAP2K40.47159756
124LRRK20.44860568
125CHEK10.43694907
126FER0.43680650
127MARK20.43661886
128DAPK30.43402053
129MAPKAPK20.43107178
130CDK90.39924745
131PRKCB0.39274504
132AURKB0.39176404
133PAK30.39030774
134RET0.38380926
135PLK10.38341879
136CSNK2A20.37202260
137STK110.36943120
138NTRK10.36842358
139CSNK2A10.36455070
140RPS6KA20.35916684
141SCYL20.35501503
142TNK20.34669278
143PRKCE0.34425468
144SRC0.34081855
145JAK10.33768429
146BMX0.33614710
147CDK120.33447681
148MAPK40.32946665
149ICK0.32608790
150MAP3K30.32337842
151WNK40.32163882
152FGFR40.31449432
153PRKACA0.31421512
154PRKCD0.31226903
155IKBKE0.31037993
156DYRK30.30811280
157MAPK110.30739873
158KSR10.30695623
159ABL10.30256517
160CASK0.29932491
161GRK70.29871414
162ATR0.28151997
163CAMK2B0.27307557
164MAP3K70.26151386
165FYN0.25898260
166CDK20.25168061
167ATM0.25015311
168TNIK0.24994746
169TRIB30.24676573
170CSNK1G30.24334260
171CSK0.23229687
172ILK0.22938410

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007904.86651727
2Steroid biosynthesis_Homo sapiens_hsa001003.43321996
3Caffeine metabolism_Homo sapiens_hsa002323.42783924
4Ribosome_Homo sapiens_hsa030103.37811184
5Leishmaniasis_Homo sapiens_hsa051403.29685589
6Sphingolipid metabolism_Homo sapiens_hsa006003.27355090
7Osteoclast differentiation_Homo sapiens_hsa043803.10477281
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02126950
9Allograft rejection_Homo sapiens_hsa053302.82431797
10Graft-versus-host disease_Homo sapiens_hsa053322.68386460
11Homologous recombination_Homo sapiens_hsa034402.68082528
12Autoimmune thyroid disease_Homo sapiens_hsa053202.65732789
13Primary immunodeficiency_Homo sapiens_hsa053402.40233703
14Fatty acid elongation_Homo sapiens_hsa000622.38052774
15Protein digestion and absorption_Homo sapiens_hsa049742.37551416
16Tuberculosis_Homo sapiens_hsa051522.35349576
17Mismatch repair_Homo sapiens_hsa034302.32472556
18Fanconi anemia pathway_Homo sapiens_hsa034602.27548108
19Asthma_Homo sapiens_hsa053102.13489091
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12829927
21Butanoate metabolism_Homo sapiens_hsa006502.09335622
22Renin-angiotensin system_Homo sapiens_hsa046142.03764806
23Type I diabetes mellitus_Homo sapiens_hsa049402.03034372
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.99963043
25One carbon pool by folate_Homo sapiens_hsa006701.98243955
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96823533
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96603851
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93679177
29Staphylococcus aureus infection_Homo sapiens_hsa051501.93522217
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93460161
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.86449065
32Viral myocarditis_Homo sapiens_hsa054161.82777965
33Hematopoietic cell lineage_Homo sapiens_hsa046401.77770337
34Phagosome_Homo sapiens_hsa041451.74546677
35Vitamin B6 metabolism_Homo sapiens_hsa007501.69238274
36Toxoplasmosis_Homo sapiens_hsa051451.59096636
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57841443
38Malaria_Homo sapiens_hsa051441.57392694
39Lysosome_Homo sapiens_hsa041421.55084796
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51030193
41Herpes simplex infection_Homo sapiens_hsa051681.49050997
42Influenza A_Homo sapiens_hsa051641.47832793
43Chemokine signaling pathway_Homo sapiens_hsa040621.47658957
44Measles_Homo sapiens_hsa051621.44273141
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.44124276
46Rheumatoid arthritis_Homo sapiens_hsa053231.35874369
47Legionellosis_Homo sapiens_hsa051341.30693053
48T cell receptor signaling pathway_Homo sapiens_hsa046601.29775625
49Axon guidance_Homo sapiens_hsa043601.20968317
50Gastric acid secretion_Homo sapiens_hsa049711.20009784
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17651141
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16796289
53DNA replication_Homo sapiens_hsa030301.16079587
54ECM-receptor interaction_Homo sapiens_hsa045121.15996564
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.15444281
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13442423
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12963921
58Non-small cell lung cancer_Homo sapiens_hsa052231.08227190
59African trypanosomiasis_Homo sapiens_hsa051431.04660566
60Propanoate metabolism_Homo sapiens_hsa006401.04082067
61Hepatitis B_Homo sapiens_hsa051611.03792899
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.03391433
63beta-Alanine metabolism_Homo sapiens_hsa004101.00819019
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.00530716
65Salmonella infection_Homo sapiens_hsa051320.97894985
66TNF signaling pathway_Homo sapiens_hsa046680.97802404
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93635270
68ABC transporters_Homo sapiens_hsa020100.92579410
69Apoptosis_Homo sapiens_hsa042100.89671119
70Pancreatic cancer_Homo sapiens_hsa052120.88883628
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88779465
72Bladder cancer_Homo sapiens_hsa052190.87528522
73Chronic myeloid leukemia_Homo sapiens_hsa052200.87422025
74Epstein-Barr virus infection_Homo sapiens_hsa051690.87233414
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85326068
76Base excision repair_Homo sapiens_hsa034100.85158354
77Amoebiasis_Homo sapiens_hsa051460.84966108
78Systemic lupus erythematosus_Homo sapiens_hsa053220.84116501
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83977728
80Bile secretion_Homo sapiens_hsa049760.83118605
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83020201
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80284687
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78006239
84Lysine degradation_Homo sapiens_hsa003100.77456093
85Phenylalanine metabolism_Homo sapiens_hsa003600.77375002
86Pancreatic secretion_Homo sapiens_hsa049720.73720159
87Estrogen signaling pathway_Homo sapiens_hsa049150.73602294
88Tight junction_Homo sapiens_hsa045300.72494980
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72277092
90Linoleic acid metabolism_Homo sapiens_hsa005910.72248614
91Endocytosis_Homo sapiens_hsa041440.70865519
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.70668914
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69854110
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.69408612
95Pentose phosphate pathway_Homo sapiens_hsa000300.67559418
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67510478
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67161136
98HTLV-I infection_Homo sapiens_hsa051660.66950445
99Starch and sucrose metabolism_Homo sapiens_hsa005000.66828427
100Cholinergic synapse_Homo sapiens_hsa047250.64934659
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64226799
102Viral carcinogenesis_Homo sapiens_hsa052030.63674069
103Histidine metabolism_Homo sapiens_hsa003400.63303294
104Renal cell carcinoma_Homo sapiens_hsa052110.62773342
105Notch signaling pathway_Homo sapiens_hsa043300.62231575
106Pyrimidine metabolism_Homo sapiens_hsa002400.61352999
107VEGF signaling pathway_Homo sapiens_hsa043700.60330190
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58153126
109Acute myeloid leukemia_Homo sapiens_hsa052210.58053662
110Platelet activation_Homo sapiens_hsa046110.55898407
111Glutamatergic synapse_Homo sapiens_hsa047240.54635593
112Other glycan degradation_Homo sapiens_hsa005110.54626158
113Sulfur relay system_Homo sapiens_hsa041220.52176624
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51508105
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51471263
116Prolactin signaling pathway_Homo sapiens_hsa049170.51300060
117Pertussis_Homo sapiens_hsa051330.49935990
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49537817
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49468040
120Basal cell carcinoma_Homo sapiens_hsa052170.47857997
121Cardiac muscle contraction_Homo sapiens_hsa042600.47841976
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.46837313
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.46700348
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46529536
125Collecting duct acid secretion_Homo sapiens_hsa049660.45913936
126Fatty acid degradation_Homo sapiens_hsa000710.45902601
127Renin secretion_Homo sapiens_hsa049240.45884898
128Retinol metabolism_Homo sapiens_hsa008300.45770283
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45389991
130Nucleotide excision repair_Homo sapiens_hsa034200.45088334
131HIF-1 signaling pathway_Homo sapiens_hsa040660.43809464
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.42656454
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.42493536
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42287725
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41893341
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.41696157
137Colorectal cancer_Homo sapiens_hsa052100.40700183
138Spliceosome_Homo sapiens_hsa030400.39708746
139Galactose metabolism_Homo sapiens_hsa000520.39113748
140Endometrial cancer_Homo sapiens_hsa052130.39032708
141Long-term depression_Homo sapiens_hsa047300.37742620
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37733274
143Peroxisome_Homo sapiens_hsa041460.37075664
144Choline metabolism in cancer_Homo sapiens_hsa052310.36539579
145Shigellosis_Homo sapiens_hsa051310.36387301
146GnRH signaling pathway_Homo sapiens_hsa049120.36176678
147Hippo signaling pathway_Homo sapiens_hsa043900.35769400
148Hepatitis C_Homo sapiens_hsa051600.35478832
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33622899
150FoxO signaling pathway_Homo sapiens_hsa040680.33382506
151Thyroid hormone synthesis_Homo sapiens_hsa049180.33374709
152Antigen processing and presentation_Homo sapiens_hsa046120.32307929
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31427580
154p53 signaling pathway_Homo sapiens_hsa041150.30163562
155Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29779717
156Tryptophan metabolism_Homo sapiens_hsa003800.29280941
157B cell receptor signaling pathway_Homo sapiens_hsa046620.28727209
158PPAR signaling pathway_Homo sapiens_hsa033200.28695080
159Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28341720
160mTOR signaling pathway_Homo sapiens_hsa041500.26475194
161Complement and coagulation cascades_Homo sapiens_hsa046100.26038333
162Glioma_Homo sapiens_hsa052140.25993106
163Fructose and mannose metabolism_Homo sapiens_hsa000510.25669233
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25590005
165Wnt signaling pathway_Homo sapiens_hsa043100.25077109
166Inositol phosphate metabolism_Homo sapiens_hsa005620.24663336
167Metabolic pathways_Homo sapiens_hsa011000.24507504
168Arachidonic acid metabolism_Homo sapiens_hsa005900.24396737
169Insulin resistance_Homo sapiens_hsa049310.24120075
170MAPK signaling pathway_Homo sapiens_hsa040100.23775944
171Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23512709
172Nitrogen metabolism_Homo sapiens_hsa009100.22512135
173Pathways in cancer_Homo sapiens_hsa052000.21715751
174Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21122308
175Small cell lung cancer_Homo sapiens_hsa052220.20844756
176Serotonergic synapse_Homo sapiens_hsa047260.17801435
177Ether lipid metabolism_Homo sapiens_hsa005650.17568896

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