SOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.78613560
2substrate-independent telencephalic tangential migration (GO:0021826)5.51500837
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.51500837
4nucleobase catabolic process (GO:0046113)5.25023854
5neuron cell-cell adhesion (GO:0007158)4.79619786
6gamma-aminobutyric acid transport (GO:0015812)4.65700614
7neuron fate determination (GO:0048664)4.51648572
8vocalization behavior (GO:0071625)4.44008031
9cerebral cortex radially oriented cell migration (GO:0021799)4.40174966
10negative regulation of oligodendrocyte differentiation (GO:0048715)4.25305993
11cell proliferation in forebrain (GO:0021846)4.24312783
12nonmotile primary cilium assembly (GO:0035058)4.24141516
13multicellular organismal aging (GO:0010259)4.03858390
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02927170
15cerebral cortex neuron differentiation (GO:0021895)3.98535224
16regulation of timing of cell differentiation (GO:0048505)3.97046366
17postsynaptic membrane organization (GO:0001941)3.91933647
18presynaptic membrane assembly (GO:0097105)3.85465357
19limb bud formation (GO:0060174)3.82999804
20pyrimidine dimer repair (GO:0006290)3.82717591
21glial cell proliferation (GO:0014009)3.80033609
22layer formation in cerebral cortex (GO:0021819)3.79292379
23neurotransmitter-gated ion channel clustering (GO:0072578)3.76614462
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75903149
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.75735465
26pattern specification involved in kidney development (GO:0061004)3.74815759
27dendritic spine morphogenesis (GO:0060997)3.71873356
28auditory behavior (GO:0031223)3.71641327
29regulation of glutamate receptor signaling pathway (GO:1900449)3.71439138
30response to auditory stimulus (GO:0010996)3.69651838
31protein localization to synapse (GO:0035418)3.68549477
32regulation of development, heterochronic (GO:0040034)3.68203642
33locomotory exploration behavior (GO:0035641)3.67221322
34proline transport (GO:0015824)3.65781146
35behavioral response to nicotine (GO:0035095)3.64803696
36forebrain neuron differentiation (GO:0021879)3.64513001
37central nervous system projection neuron axonogenesis (GO:0021952)3.59985488
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.54970754
39somite development (GO:0061053)3.52674312
40olfactory bulb development (GO:0021772)3.52301118
41neuron recognition (GO:0008038)3.50999999
42positive regulation of synapse assembly (GO:0051965)3.47523782
43presynaptic membrane organization (GO:0097090)3.47027651
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45319796
45tongue development (GO:0043586)3.44758137
46appendage development (GO:0048736)3.43952050
47limb development (GO:0060173)3.43952050
48glycine transport (GO:0015816)3.41736003
49segment specification (GO:0007379)3.40119255
50L-amino acid import (GO:0043092)3.39291001
51axonal fasciculation (GO:0007413)3.36890675
52radial glial cell differentiation (GO:0060019)3.33789296
53synaptic transmission, glutamatergic (GO:0035249)3.32155789
54retinal ganglion cell axon guidance (GO:0031290)3.29971844
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28413088
56negative regulation of astrocyte differentiation (GO:0048712)3.26629763
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26565924
58establishment of mitochondrion localization (GO:0051654)3.25360613
59regulation of respiratory system process (GO:0044065)3.24412016
60lens development in camera-type eye (GO:0002088)3.21940497
61regulation of synaptic vesicle exocytosis (GO:2000300)3.21723116
62glutamate receptor signaling pathway (GO:0007215)3.21109816
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19651719
64cerebral cortex cell migration (GO:0021795)3.19027497
65glutamate secretion (GO:0014047)3.17954517
66dendrite morphogenesis (GO:0048813)3.17953928
67alanine transport (GO:0032328)3.17845070
68neurotransmitter secretion (GO:0007269)3.14309376
69lateral sprouting from an epithelium (GO:0060601)3.12988224
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11655421
71startle response (GO:0001964)3.09593067
72cerebellar granule cell differentiation (GO:0021707)3.08866488
73spinal cord development (GO:0021510)3.06820513
74amino acid import (GO:0043090)3.05653543
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.05642173
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05254369
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05007982
78synaptic vesicle exocytosis (GO:0016079)3.04763344
79neurotransmitter uptake (GO:0001504)3.04583380
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03498835
81axon ensheathment in central nervous system (GO:0032291)3.01375793
82central nervous system myelination (GO:0022010)3.01375793
83synapse assembly (GO:0007416)3.01265489
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00384532
85transmission of nerve impulse (GO:0019226)2.99500683
86regulation of neuronal synaptic plasticity (GO:0048168)2.99413523
87regulation of synaptic vesicle transport (GO:1902803)2.97134756
88lens fiber cell development (GO:0070307)2.96666639
89negative regulation of glial cell differentiation (GO:0045686)2.96645786
90synaptic vesicle maturation (GO:0016188)2.96581612
91regulation of synapse assembly (GO:0051963)2.95814737
92cilium movement (GO:0003341)2.95416669
93neuron-neuron synaptic transmission (GO:0007270)2.93210473
94hippocampus development (GO:0021766)2.92324482
95long-term memory (GO:0007616)2.91645262
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91592295
97cranial nerve morphogenesis (GO:0021602)2.90689628
98camera-type eye morphogenesis (GO:0048593)2.90268129
99mechanosensory behavior (GO:0007638)2.89668094
100neuronal ion channel clustering (GO:0045161)2.88868942
101cell communication by electrical coupling (GO:0010644)2.87982180
102cell migration in hindbrain (GO:0021535)2.87669726
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.87585805
104negative regulation of catenin import into nucleus (GO:0035414)2.86139739
105positive regulation of neural precursor cell proliferation (GO:2000179)2.85902198
106heart valve formation (GO:0003188)2.84954408
107intraciliary transport (GO:0042073)2.84821605
108apical protein localization (GO:0045176)2.84276864
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.83941884
110spinal cord association neuron differentiation (GO:0021527)2.83784895
111cellular potassium ion homeostasis (GO:0030007)2.83606649
112regulation of synapse structural plasticity (GO:0051823)2.82783679
113regulation of respiratory gaseous exchange (GO:0043576)2.81223404
114otic vesicle formation (GO:0030916)2.79215192
115negative regulation of sodium ion transport (GO:0010766)2.78794210
116neuronal stem cell maintenance (GO:0097150)2.77574243
117exploration behavior (GO:0035640)2.76260052
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.75464471
119innervation (GO:0060384)2.75281401
120positive regulation of neuroblast proliferation (GO:0002052)2.74607775
121neurotransmitter transport (GO:0006836)2.73496720
122artery development (GO:0060840)2.73277985
123cellular response to cholesterol (GO:0071397)2.72300841
124central nervous system neuron differentiation (GO:0021953)2.69057461
125neural precursor cell proliferation (GO:0061351)2.68185058
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67981650
127central nervous system neuron axonogenesis (GO:0021955)2.67713858
128proximal/distal pattern formation (GO:0009954)2.66328315
129smoothened signaling pathway (GO:0007224)2.64537656
130* neuron migration (GO:0001764)2.62482115
131regulation of oligodendrocyte differentiation (GO:0048713)2.61645310
132telencephalon cell migration (GO:0022029)2.61400172
133positive regulation of Notch signaling pathway (GO:0045747)2.59954881
134forebrain cell migration (GO:0021885)2.59488661
135neuron fate commitment (GO:0048663)2.58929768
136hindbrain development (GO:0030902)2.58602780
137astrocyte differentiation (GO:0048708)2.58416727
138positive regulation of vascular permeability (GO:0043117)2.57575381
139Sertoli cell development (GO:0060009)2.56160597
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54323342
141auditory receptor cell differentiation (GO:0042491)2.54180498
142telencephalon development (GO:0021537)2.53990957
143cardiovascular system development (GO:0072358)2.53719938
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52649894
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.52649894
146regulation of translation, ncRNA-mediated (GO:0045974)2.52649894
147adult walking behavior (GO:0007628)2.50639601
148pituitary gland development (GO:0021983)2.50464480
149epithelial cilium movement (GO:0003351)2.50102548
150ganglion development (GO:0061548)2.49710507
151thalamus development (GO:0021794)2.46663019
152establishment of planar polarity (GO:0001736)2.46498470
153establishment of tissue polarity (GO:0007164)2.46498470
154dorsal/ventral pattern formation (GO:0009953)2.46469410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99616814
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18703145
3GBX2_23144817_ChIP-Seq_PC3_Human3.06627217
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96235057
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.95957381
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88777051
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.78297522
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72728417
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70962664
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70962664
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65861398
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51003588
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44671633
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.37996201
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37132913
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34462224
17* CBX2_27304074_Chip-Seq_ESCs_Mouse2.28157422
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16999964
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16796178
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12756325
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07232122
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07028024
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06703371
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.05551180
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.03078052
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02889615
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.02345441
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97526336
29AR_21572438_ChIP-Seq_LNCaP_Human1.91457024
30DROSHA_22980978_ChIP-Seq_HELA_Human1.89519559
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86410171
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.68603718
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67426965
34VDR_22108803_ChIP-Seq_LS180_Human1.66933604
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66898044
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.63455957
37P300_19829295_ChIP-Seq_ESCs_Human1.63431098
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62177155
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.55591100
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53905797
41* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50753876
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50524219
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.49706362
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47159889
45* REST_18959480_ChIP-ChIP_MESCs_Mouse1.46039312
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45716646
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44904439
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44130704
49SMAD4_21799915_ChIP-Seq_A2780_Human1.44004870
50* RNF2_27304074_Chip-Seq_NSC_Mouse1.39208411
51EWS_26573619_Chip-Seq_HEK293_Human1.36894685
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36824978
53* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34980546
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.28806168
55* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28721723
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.27026320
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26313052
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25236255
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24839490
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.21474232
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20687974
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.20103772
63IRF1_19129219_ChIP-ChIP_H3396_Human1.19011915
64* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18824092
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17973755
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17934526
67FUS_26573619_Chip-Seq_HEK293_Human1.17687864
68* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17614521
69AR_25329375_ChIP-Seq_VCAP_Human1.17387541
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16818515
71SOX9_26525672_Chip-Seq_HEART_Mouse1.16613795
72IGF1R_20145208_ChIP-Seq_DFB_Human1.16571641
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16072547
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16072547
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14976405
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14322193
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.13692203
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13321366
79STAT3_23295773_ChIP-Seq_U87_Human1.13239596
80AR_19668381_ChIP-Seq_PC3_Human1.13127839
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.12296713
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11690321
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08541855
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08369844
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08161288
86TAF15_26573619_Chip-Seq_HEK293_Human1.08073003
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07971188
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07791660
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07678573
90* SMAD3_21741376_ChIP-Seq_ESCs_Human1.06845126
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06136250
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05369804
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04179090
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.04111526
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.03276531
96* TCF4_23295773_ChIP-Seq_U87_Human1.02796339
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02174987
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01652927
99* TP53_18474530_ChIP-ChIP_U2OS_Human1.01288086
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00416076
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99987345
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.99181671
103AHR_22903824_ChIP-Seq_MCF-7_Human0.98990716
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.98435609
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98299675
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98025766
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97853077
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97733218
109ZNF274_21170338_ChIP-Seq_K562_Hela0.97640861
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97268215
111* CBP_20019798_ChIP-Seq_JUKART_Human0.97251172
112* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97251172
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96752157
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95457502
115* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95444332
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95383275
117BCAT_22108803_ChIP-Seq_LS180_Human0.95038546
118WDR5_24793694_ChIP-Seq_LNCAP_Human0.94916074
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94316697
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.94283744
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93841442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.56983506
2MP0006292_abnormal_olfactory_placode2.91510640
3MP0005423_abnormal_somatic_nervous2.88005966
4MP0003635_abnormal_synaptic_transmissio2.68318708
5MP0003880_abnormal_central_pattern2.66188697
6MP0009046_muscle_twitch2.57427210
7MP0000778_abnormal_nervous_system2.52797764
8MP0004858_abnormal_nervous_system2.38042170
9MP0009745_abnormal_behavioral_response2.37408259
10MP0002063_abnormal_learning/memory/cond2.36393991
11MP0002064_seizures2.34000339
12MP0002249_abnormal_larynx_morphology2.32281989
13MP0001486_abnormal_startle_reflex2.31742771
14MP0002572_abnormal_emotion/affect_behav2.26473345
15MP0004885_abnormal_endolymph2.26052444
16MP0005645_abnormal_hypothalamus_physiol2.18741074
17MP0003136_yellow_coat_color2.14903426
18MP0001485_abnormal_pinna_reflex1.96801425
19MP0000049_abnormal_middle_ear1.93651809
20MP0004270_analgesia1.93219989
21MP0001502_abnormal_circadian_rhythm1.91503961
22MP0004142_abnormal_muscle_tone1.91302869
23MP0005646_abnormal_pituitary_gland1.91234190
24MP0002272_abnormal_nervous_system1.87839341
25MP0001529_abnormal_vocalization1.84165335
26MP0010030_abnormal_orbit_morphology1.82722387
27MP0001293_anophthalmia1.81945088
28MP0001968_abnormal_touch/_nociception1.79413712
29MP0004742_abnormal_vestibular_system1.74001616
30MP0002638_abnormal_pupillary_reflex1.73733096
31* MP0002557_abnormal_social/conspecific_i1.72965674
32MP0002733_abnormal_thermal_nociception1.69732466
33MP0002734_abnormal_mechanical_nocicepti1.68451825
34MP0006276_abnormal_autonomic_nervous1.67397001
35MP0009379_abnormal_foot_pigmentation1.66407069
36MP0002067_abnormal_sensory_capabilities1.66347902
37MP0001348_abnormal_lacrimal_gland1.66044574
38MP0002184_abnormal_innervation1.61135062
39MP0000631_abnormal_neuroendocrine_gland1.59095475
40MP0003787_abnormal_imprinting1.58955615
41MP0005377_hearing/vestibular/ear_phenot1.57536701
42MP0003878_abnormal_ear_physiology1.57536701
43MP0002233_abnormal_nose_morphology1.55115215
44MP0002653_abnormal_ependyma_morphology1.51702399
45MP0000566_synostosis1.50082346
46MP0008789_abnormal_olfactory_epithelium1.49094595
47MP0002736_abnormal_nociception_after1.47332727
48MP0001188_hyperpigmentation1.39941559
49MP0008569_lethality_at_weaning1.39077414
50MP0005499_abnormal_olfactory_system1.38784356
51MP0005394_taste/olfaction_phenotype1.38784356
52* MP0002697_abnormal_eye_size1.38132029
53MP0002234_abnormal_pharynx_morphology1.36297430
54MP0004811_abnormal_neuron_physiology1.33731592
55MP0002882_abnormal_neuron_morphology1.33613683
56MP0000955_abnormal_spinal_cord1.33296242
57MP0001440_abnormal_grooming_behavior1.32862123
58MP0004133_heterotaxia1.32643661
59MP0003122_maternal_imprinting1.32377372
60MP0001970_abnormal_pain_threshold1.32303118
61MP0005171_absent_coat_pigmentation1.29751324
62MP0000428_abnormal_craniofacial_morphol1.29378278
63MP0003938_abnormal_ear_development1.29310084
64* MP0002152_abnormal_brain_morphology1.28597171
65MP0004043_abnormal_pH_regulation1.28495416
66MP0001984_abnormal_olfaction1.27951761
67MP0000026_abnormal_inner_ear1.27593308
68MP0002822_catalepsy1.26212610
69MP0000516_abnormal_urinary_system1.25236393
70MP0005367_renal/urinary_system_phenotyp1.25236393
71MP0003119_abnormal_digestive_system1.24612379
72MP0002735_abnormal_chemical_nociception1.24405929
73* MP0001286_abnormal_eye_development1.24077129
74MP0008877_abnormal_DNA_methylation1.21804717
75MP0009053_abnormal_anal_canal1.21736392
76MP0003861_abnormal_nervous_system1.19265224
77MP0002138_abnormal_hepatobiliary_system1.18055835
78MP0001501_abnormal_sleep_pattern1.13345105
79MP0005391_vision/eye_phenotype1.10248445
80MP0004924_abnormal_behavior1.10188776
81MP0005386_behavior/neurological_phenoty1.10188776
82MP0005253_abnormal_eye_physiology1.08903329
83MP0002066_abnormal_motor_capabilities/c1.08879372
84MP0003634_abnormal_glial_cell1.08568603
85MP0000013_abnormal_adipose_tissue1.07358588
86MP0002092_abnormal_eye_morphology1.07249490
87MP0005195_abnormal_posterior_eye1.06284553
88MP0003755_abnormal_palate_morphology1.05981153
89MP0002102_abnormal_ear_morphology1.04896950
90MP0003942_abnormal_urinary_system1.04537748
91MP0001963_abnormal_hearing_physiology1.03105352
92MP0003385_abnormal_body_wall0.98660524
93MP0002116_abnormal_craniofacial_bone0.98167329
94MP0002752_abnormal_somatic_nervous0.96143471
95MP0005248_abnormal_Harderian_gland0.95934442
96MP0003690_abnormal_glial_cell0.92174699
97MP0001270_distended_abdomen0.89621829
98MP0001299_abnormal_eye_distance/0.89218266
99MP0002081_perinatal_lethality0.89041308
100MP0006072_abnormal_retinal_apoptosis0.88785959
101MP0005551_abnormal_eye_electrophysiolog0.88563328
102MP0002751_abnormal_autonomic_nervous0.88440179
103MP0003121_genomic_imprinting0.87176484
104MP0000534_abnormal_ureter_morphology0.86981265
105MP0003941_abnormal_skin_development0.86805169
106MP0004134_abnormal_chest_morphology0.84981971
107MP0003890_abnormal_embryonic-extraembry0.82828613
108MP0005379_endocrine/exocrine_gland_phen0.82424362
109MP0000678_abnormal_parathyroid_gland0.82111812
110MP0003937_abnormal_limbs/digits/tail_de0.81091977
111MP0000537_abnormal_urethra_morphology0.80614866
112MP0002069_abnormal_eating/drinking_beha0.80188338
113MP0009384_cardiac_valve_regurgitation0.79860507
114MP0002938_white_spotting0.76673528
115MP0002909_abnormal_adrenal_gland0.76344899
116MP0001346_abnormal_lacrimal_gland0.76193903
117MP0005187_abnormal_penis_morphology0.75616980
118MP0003935_abnormal_craniofacial_develop0.75517481
119MP0002111_abnormal_tail_morphology0.74118996
120MP0003283_abnormal_digestive_organ0.68970318
121MP0002282_abnormal_trachea_morphology0.68871615

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)6.06889843
2Zonular cataract (HP:0010920)5.11294393
3Morphological abnormality of the middle ear (HP:0008609)3.99719896
4Limb dystonia (HP:0002451)3.82890031
5Focal motor seizures (HP:0011153)3.73568823
6Bilateral microphthalmos (HP:0007633)3.60588173
7Abnormal ciliary motility (HP:0012262)3.48972417
8Failure to thrive in infancy (HP:0001531)3.37777718
9Oligodactyly (hands) (HP:0001180)3.24142888
10Megalencephaly (HP:0001355)3.19337041
11Oligodactyly (HP:0012165)3.14427359
12Abnormality of the aortic arch (HP:0012303)3.10626126
13Short 4th metacarpal (HP:0010044)3.06168566
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.06168566
15Abnormal respiratory motile cilium physiology (HP:0012261)2.99418953
16Large eyes (HP:0001090)2.94499780
17Epileptic encephalopathy (HP:0200134)2.94269186
18Abnormality of the 4th metacarpal (HP:0010012)2.87984364
19Abnormality of the labia minora (HP:0012880)2.86380483
20Hemiparesis (HP:0001269)2.81521008
21Progressive cerebellar ataxia (HP:0002073)2.78979982
22Pancreatic fibrosis (HP:0100732)2.77335612
23Hyperacusis (HP:0010780)2.75417219
24Rib fusion (HP:0000902)2.75024357
25Abnormality of chromosome segregation (HP:0002916)2.73854752
26Hepatoblastoma (HP:0002884)2.72631644
27Tented upper lip vermilion (HP:0010804)2.71222787
28Renal dysplasia (HP:0000110)2.69785802
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.64828785
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.62497833
31Absent/shortened dynein arms (HP:0200106)2.62497833
32Abnormality of the metopic suture (HP:0005556)2.59032061
33Septo-optic dysplasia (HP:0100842)2.58962683
34Drooling (HP:0002307)2.56736427
35Excessive salivation (HP:0003781)2.56736427
36Focal seizures (HP:0007359)2.53200187
37Midline defect of the nose (HP:0004122)2.52184542
38High anterior hairline (HP:0009890)2.51319087
39Myokymia (HP:0002411)2.48316493
40Abnormal respiratory motile cilium morphology (HP:0005938)2.47812744
41Abnormal respiratory epithelium morphology (HP:0012253)2.47812744
42Molar tooth sign on MRI (HP:0002419)2.47191612
43Abnormality of midbrain morphology (HP:0002418)2.47191612
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.46613758
45Ankle clonus (HP:0011448)2.44287935
46Febrile seizures (HP:0002373)2.43213168
47Pancreatic cysts (HP:0001737)2.42869094
48Broad alveolar ridges (HP:0000187)2.41660807
49Nephronophthisis (HP:0000090)2.40837388
50Hyperventilation (HP:0002883)2.40314934
51Trigonocephaly (HP:0000243)2.38536714
52Amblyopia (HP:0000646)2.34817492
53Broad face (HP:0000283)2.34585566
54Anencephaly (HP:0002323)2.34555704
55Aplasia involving bones of the upper limbs (HP:0009823)2.33206272
56Aplasia of the phalanges of the hand (HP:0009802)2.33206272
57Aplasia involving bones of the extremities (HP:0009825)2.33206272
58Prominent metopic ridge (HP:0005487)2.30713056
59Hemivertebrae (HP:0002937)2.29189642
60Congenital primary aphakia (HP:0007707)2.28887653
61Specific learning disability (HP:0001328)2.28398168
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28016698
63Cortical dysplasia (HP:0002539)2.25582096
64Intestinal atresia (HP:0011100)2.16888577
65Postaxial hand polydactyly (HP:0001162)2.14232512
66Fibular hypoplasia (HP:0003038)2.13851656
67Growth hormone deficiency (HP:0000824)2.12615001
68Genital tract atresia (HP:0001827)2.11610218
69Abnormality of the dental root (HP:0006486)2.11519077
70Taurodontia (HP:0000679)2.11519077
71Abnormality of permanent molar morphology (HP:0011071)2.11519077
72Gait imbalance (HP:0002141)2.11452944
73Abnormality of binocular vision (HP:0011514)2.11293663
74Diplopia (HP:0000651)2.11293663
75Colon cancer (HP:0003003)2.10689174
76Abnormality of molar (HP:0011077)2.10387807
77Abnormality of molar morphology (HP:0011070)2.10387807
78Vaginal atresia (HP:0000148)2.09651650
79Abnormality of the ischium (HP:0003174)2.09456253
80Abnormal number of incisors (HP:0011064)2.09049016
81Facial hemangioma (HP:0000329)2.08545959
82Dysdiadochokinesis (HP:0002075)2.08374761
83Medial flaring of the eyebrow (HP:0010747)2.08048365
84Broad-based gait (HP:0002136)2.08039425
85Lissencephaly (HP:0001339)2.05843797
86Postaxial foot polydactyly (HP:0001830)2.05271240
87Maternal diabetes (HP:0009800)2.05088895
88Vitreoretinal degeneration (HP:0000655)2.04497973
89Holoprosencephaly (HP:0001360)2.04430231
90Esophageal atresia (HP:0002032)2.03335249
91True hermaphroditism (HP:0010459)2.02609061
92Reticulocytopenia (HP:0001896)2.01822439
93Neonatal short-limb short stature (HP:0008921)2.00142390
94Anophthalmia (HP:0000528)1.98952622
95Type II lissencephaly (HP:0007260)1.98892940
96Cystic liver disease (HP:0006706)1.98855626
97Abnormality of the dental pulp (HP:0006479)1.97655806
98Abnormality of the renal medulla (HP:0100957)1.96910681
99Retinal dysplasia (HP:0007973)1.96305698
100Chronic hepatic failure (HP:0100626)1.95200656
101Hemiplegia (HP:0002301)1.95181568
102Poor coordination (HP:0002370)1.94904615
103Genetic anticipation (HP:0003743)1.94415998
104Absence seizures (HP:0002121)1.94398660
105Fetal akinesia sequence (HP:0001989)1.93581238
106EEG with generalized epileptiform discharges (HP:0011198)1.92795111
107Pendular nystagmus (HP:0012043)1.92144323
108Epileptiform EEG discharges (HP:0011182)1.90976512
109Atonic seizures (HP:0010819)1.90566685
110Abnormality of the diencephalon (HP:0010662)1.90558441
111Hypsarrhythmia (HP:0002521)1.90393930
112Micropenis (HP:0000054)1.90103152
113Obstructive sleep apnea (HP:0002870)1.89393772
114Pachygyria (HP:0001302)1.88554921
115Preaxial hand polydactyly (HP:0001177)1.88316617
116Split foot (HP:0001839)1.87065381
117Stereotypic behavior (HP:0000733)1.86950540
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86719665
119Renal hypoplasia (HP:0000089)1.86654190
120Autism (HP:0000717)1.86624748
121Lower limb muscle weakness (HP:0007340)1.86045956
122Coronal craniosynostosis (HP:0004440)1.85327324
123Gastrointestinal atresia (HP:0002589)1.85081229
124Down-sloping shoulders (HP:0200021)1.83401837
125Narrow forehead (HP:0000341)1.83292223
126Hypoplastic ischia (HP:0003175)1.83252509
127Aqueductal stenosis (HP:0002410)1.83042882
128Morphological abnormality of the inner ear (HP:0011390)1.82853105
129Absent eyebrow (HP:0002223)1.82693833
130Impaired vibration sensation in the lower limbs (HP:0002166)1.82003298
131Broad foot (HP:0001769)1.81348025
13211 pairs of ribs (HP:0000878)1.80852150
133Rhinitis (HP:0012384)1.80021357
134Hyperthyroidism (HP:0000836)1.79340849
135Absent septum pellucidum (HP:0001331)1.79064306
136Corneal dystrophy (HP:0001131)1.77118812
137Cutaneous finger syndactyly (HP:0010554)1.76889847
138Action tremor (HP:0002345)1.76768931
139Aplasia/Hypoplasia of the lens (HP:0008063)1.75702229
140Ectopic kidney (HP:0000086)1.75580858
141Cutaneous syndactyly (HP:0012725)1.74960681
142Aplasia/Hypoplasia of the fibula (HP:0006492)1.74523981
143Sclerocornea (HP:0000647)1.74474976
144Missing ribs (HP:0000921)1.73217751
145Hypoplastic iliac wings (HP:0002866)1.73103865
146Abnormality of the septum pellucidum (HP:0007375)1.71628156
147Atelectasis (HP:0100750)1.71273904
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.71001574
149Optic nerve coloboma (HP:0000588)1.70904040
150Generalized tonic-clonic seizures (HP:0002069)1.70328773
151Tetraplegia (HP:0002445)1.69231371
152Thickened helices (HP:0000391)1.69038391
153Optic nerve hypoplasia (HP:0000609)1.68875327
154Patellar aplasia (HP:0006443)1.68242601
155Abnormality of the pubic bones (HP:0003172)1.67958149
156Cerebellar dysplasia (HP:0007033)1.67752984
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.67650476
158Vertebral hypoplasia (HP:0008417)1.67650476
159Dialeptic seizures (HP:0011146)1.67622258
160Deeply set eye (HP:0000490)1.66745599
161Urinary bladder sphincter dysfunction (HP:0002839)1.66719434
162Abnormality of salivation (HP:0100755)1.66466184
163Nephrogenic diabetes insipidus (HP:0009806)1.61765425
164Absent hair (HP:0002298)1.61432013
165Abnormal eating behavior (HP:0100738)1.60822176
166Abnormality of the nasal septum (HP:0000419)1.59669958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59099454
2MARK14.19811547
3PRPF4B3.12641150
4EPHA42.98942312
5NTRK22.98079845
6NTRK32.85957497
7TNIK2.31044740
8MKNK22.28459969
9SIK22.25745438
10MAPK152.19315197
11EPHB22.15127727
12SGK21.95505996
13MAPK131.92942219
14STK161.89957482
15PNCK1.87992563
16MAP3K91.85491582
17MAP3K41.71700209
18SGK2231.66587990
19SGK4941.66587990
20MAP2K71.64398811
21KSR11.62893725
22PHKG21.61833849
23PHKG11.61833849
24WEE11.58784996
25CDC71.58658733
26MINK11.43954334
27ERBB31.40986663
28TLK11.33776371
29SGK31.33146186
30SIK31.33069345
31PAK61.30553575
32MKNK11.30223413
33IRAK21.29478209
34FGFR21.28963184
35WNK41.25257266
36LMTK21.22898867
37CDK51.18017119
38EPHA31.15534534
39TAOK21.15530724
40NUAK11.15468833
41YES11.12775510
42MAP4K21.10419112
43DYRK1A1.09929713
44PLK21.06459280
45DYRK1B1.05991102
46PRKCG1.01339613
47UHMK11.01291153
48PRKD31.00391985
49PINK10.98266936
50PKN10.97901420
51CAMK1G0.96714163
52DAPK20.95912574
53TRIB30.94932796
54BCR0.93141281
55SGK10.92571103
56DYRK20.92169381
57ICK0.92158612
58GRK10.92143314
59CSNK1G10.91761952
60NEK20.89241122
61SIK10.86830125
62STK390.85122498
63DYRK30.84072900
64TRIM280.82434056
65CCNB10.80485170
66SRPK10.80258650
67NEK60.78785257
68WNK30.77633208
69CDK30.76772991
70MAP2K40.75119174
71ROCK10.74666600
72CSNK1G20.73757088
73CAMKK10.72987700
74CAMK2A0.72414558
75MAP3K100.69163748
76VRK10.68990549
77RPS6KA40.67211632
78IRAK10.67194934
79PRKCE0.66919405
80LATS20.66902486
81ERBB40.66586011
82CAMK1D0.64394532
83ADRBK10.61668166
84ROCK20.59972075
85BMPR1B0.59920062
86CDK140.59909068
87PLK40.59515995
88CDK180.59395421
89INSRR0.59192721
90CSNK1G30.59085665
91CDK150.58253795
92CSNK1A1L0.57577868
93ERBB20.57168654
94PRKG10.56810340
95FRK0.56763737
96MARK20.56230369
97MOS0.55185274
98NTRK10.54697678
99PAK30.53337083
100CDK11A0.51876663
101TYRO30.50617795
102PLK30.50003532
103FES0.49764283
104TGFBR10.49672884
105CAMK2B0.48448025
106TSSK60.48150233
107BRD40.47961619
108AKT30.47626599
109PRKCH0.46966856
110CAMK10.45752390
111STK110.45370463
112PRKCZ0.44276288
113MAP3K20.43967657
114RPS6KA30.43578911
115PLK10.42826176
116ATR0.41581371
117MAPK100.41369490
118CSNK1E0.40409817
119MUSK0.39271420
120PRKCB0.38687046
121CSNK1A10.38665062
122RPS6KA60.37999761
123MAP2K60.37443020
124STK38L0.37380222
125DMPK0.37376785
126CDC42BPA0.37313909
127CDK190.36668713
128BRAF0.35921351
129PASK0.35738327
130AKT20.35669382
131AURKB0.34842290
132CAMK40.33691296
133ALK0.32321325
134PRKACA0.31793578
135LATS10.31710452
136MAPK80.31359887

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41440536
2GABAergic synapse_Homo sapiens_hsa047273.03400081
3Morphine addiction_Homo sapiens_hsa050322.71751993
4Glutamatergic synapse_Homo sapiens_hsa047242.51003329
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46143597
6Synaptic vesicle cycle_Homo sapiens_hsa047212.32311829
7Olfactory transduction_Homo sapiens_hsa047402.31559792
8Nitrogen metabolism_Homo sapiens_hsa009102.29168149
9Steroid biosynthesis_Homo sapiens_hsa001002.13420891
10Circadian entrainment_Homo sapiens_hsa047132.12309937
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03903034
12Axon guidance_Homo sapiens_hsa043601.96694836
13Taste transduction_Homo sapiens_hsa047421.81716908
14Amphetamine addiction_Homo sapiens_hsa050311.76567857
15Cocaine addiction_Homo sapiens_hsa050301.75973059
16Dopaminergic synapse_Homo sapiens_hsa047281.73076948
17Long-term potentiation_Homo sapiens_hsa047201.73039177
18Ribosome_Homo sapiens_hsa030101.70551941
19Basal cell carcinoma_Homo sapiens_hsa052171.69233238
20Serotonergic synapse_Homo sapiens_hsa047261.68954434
21Insulin secretion_Homo sapiens_hsa049111.67025396
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65488274
23Long-term depression_Homo sapiens_hsa047301.62734688
24Salivary secretion_Homo sapiens_hsa049701.56463934
25Gastric acid secretion_Homo sapiens_hsa049711.49963326
26Cholinergic synapse_Homo sapiens_hsa047251.46338205
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42493630
28Melanogenesis_Homo sapiens_hsa049161.41868014
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39757161
30Hedgehog signaling pathway_Homo sapiens_hsa043401.37041479
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33165713
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32348280
33Gap junction_Homo sapiens_hsa045401.29614263
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27794116
35Renin secretion_Homo sapiens_hsa049241.27715494
36Dorso-ventral axis formation_Homo sapiens_hsa043201.27381020
37ErbB signaling pathway_Homo sapiens_hsa040121.27199727
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26720677
39Wnt signaling pathway_Homo sapiens_hsa043101.23959264
40Calcium signaling pathway_Homo sapiens_hsa040201.23159872
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21979642
42cAMP signaling pathway_Homo sapiens_hsa040241.20631278
43Sulfur relay system_Homo sapiens_hsa041221.19904572
44Basal transcription factors_Homo sapiens_hsa030221.18896925
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18473999
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17988898
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17483803
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13857957
49Alcoholism_Homo sapiens_hsa050341.10972402
50Oxytocin signaling pathway_Homo sapiens_hsa049211.08221994
51Fanconi anemia pathway_Homo sapiens_hsa034601.07947998
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07878091
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06287698
54Protein export_Homo sapiens_hsa030601.04904954
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02547017
56Glioma_Homo sapiens_hsa052140.98032581
57Lysine degradation_Homo sapiens_hsa003100.97499001
58Spliceosome_Homo sapiens_hsa030400.96975162
59Hippo signaling pathway_Homo sapiens_hsa043900.96067315
60Estrogen signaling pathway_Homo sapiens_hsa049150.95422038
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95101592
62Huntingtons disease_Homo sapiens_hsa050160.92964710
63Nucleotide excision repair_Homo sapiens_hsa034200.91669701
64Fatty acid biosynthesis_Homo sapiens_hsa000610.91334813
65Endometrial cancer_Homo sapiens_hsa052130.89254244
66GnRH signaling pathway_Homo sapiens_hsa049120.88745650
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.87232322
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86685486
69Phototransduction_Homo sapiens_hsa047440.86156905
70RNA degradation_Homo sapiens_hsa030180.85462363
71MAPK signaling pathway_Homo sapiens_hsa040100.85124028
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84957946
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84389279
74Propanoate metabolism_Homo sapiens_hsa006400.84004900
75Linoleic acid metabolism_Homo sapiens_hsa005910.83598801
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80057219
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78863646
78Ras signaling pathway_Homo sapiens_hsa040140.77780062
79Circadian rhythm_Homo sapiens_hsa047100.77261530
80Type I diabetes mellitus_Homo sapiens_hsa049400.76339976
81Renal cell carcinoma_Homo sapiens_hsa052110.76102131
82Base excision repair_Homo sapiens_hsa034100.75683456
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75498543
84RNA polymerase_Homo sapiens_hsa030200.75319211
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73321047
86Parkinsons disease_Homo sapiens_hsa050120.73301928
87Melanoma_Homo sapiens_hsa052180.73075782
88Oocyte meiosis_Homo sapiens_hsa041140.71030135
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70220144
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69956642
91Rap1 signaling pathway_Homo sapiens_hsa040150.69420883
92Choline metabolism in cancer_Homo sapiens_hsa052310.68588237
93mRNA surveillance pathway_Homo sapiens_hsa030150.66920898
94Type II diabetes mellitus_Homo sapiens_hsa049300.65318986
95Homologous recombination_Homo sapiens_hsa034400.63797704
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63006476
97Cell cycle_Homo sapiens_hsa041100.62963135
98Oxidative phosphorylation_Homo sapiens_hsa001900.61324024
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61247442
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61015837
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60995253
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60119364
103Adherens junction_Homo sapiens_hsa045200.59178266
104Prion diseases_Homo sapiens_hsa050200.58257209
105Colorectal cancer_Homo sapiens_hsa052100.58054508
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56388573
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.55285366
108beta-Alanine metabolism_Homo sapiens_hsa004100.55279802
109Cardiac muscle contraction_Homo sapiens_hsa042600.54528784
110Notch signaling pathway_Homo sapiens_hsa043300.53214314
111Tight junction_Homo sapiens_hsa045300.52496426
112Mismatch repair_Homo sapiens_hsa034300.51723278
113Dilated cardiomyopathy_Homo sapiens_hsa054140.50863192
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.49756728
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48364771
116Ether lipid metabolism_Homo sapiens_hsa005650.48139825
117Peroxisome_Homo sapiens_hsa041460.47400470
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46948225
119Butanoate metabolism_Homo sapiens_hsa006500.45331984
120Collecting duct acid secretion_Homo sapiens_hsa049660.43736600
121Insulin signaling pathway_Homo sapiens_hsa049100.42501359
122Pathways in cancer_Homo sapiens_hsa052000.41875338
123Mineral absorption_Homo sapiens_hsa049780.41275914
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40737924
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.40545187
126Alzheimers disease_Homo sapiens_hsa050100.40250360
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39836359
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38971247
129Thyroid hormone synthesis_Homo sapiens_hsa049180.37954103
130MicroRNAs in cancer_Homo sapiens_hsa052060.37130160
131Fatty acid metabolism_Homo sapiens_hsa012120.36994929
132Prostate cancer_Homo sapiens_hsa052150.36281942
133TGF-beta signaling pathway_Homo sapiens_hsa043500.34845108
134Glucagon signaling pathway_Homo sapiens_hsa049220.34312602
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32947158
136Non-small cell lung cancer_Homo sapiens_hsa052230.32938147

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