SOX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ensheathment of neurons (GO:0007272)6.91620437
2axon ensheathment (GO:0008366)6.91620437
3myelination (GO:0042552)6.81520131
4fatty acid elongation (GO:0030497)5.97528819
5myelin maintenance (GO:0043217)5.96432104
6tyrosine metabolic process (GO:0006570)5.16722508
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.07393609
8* melanocyte differentiation (GO:0030318)4.90356650
9long-chain fatty acid biosynthetic process (GO:0042759)4.78543596
10* pigment cell differentiation (GO:0050931)4.77464798
11developmental pigmentation (GO:0048066)4.77113965
12sodium ion export (GO:0071436)4.68743048
13phenol-containing compound biosynthetic process (GO:0046189)4.49841131
14basement membrane organization (GO:0071711)4.47137541
15* oligodendrocyte differentiation (GO:0048709)4.43518448
16chondroitin sulfate catabolic process (GO:0030207)4.38250233
17negative regulation of protein localization to cell surface (GO:2000009)4.31960909
18L-amino acid import (GO:0043092)4.29468177
19regulation of collateral sprouting (GO:0048670)4.26064823
20peripheral nervous system axon ensheathment (GO:0032292)4.23676664
21myelination in peripheral nervous system (GO:0022011)4.23676664
22semaphorin-plexin signaling pathway (GO:0071526)4.23097345
23cellular potassium ion homeostasis (GO:0030007)4.23058127
24negative regulation of neurotransmitter secretion (GO:0046929)4.20731262
25creatine metabolic process (GO:0006600)4.16266826
26peptidyl-tyrosine autophosphorylation (GO:0038083)4.09551406
27photoreceptor cell differentiation (GO:0046530)4.09121079
28eye photoreceptor cell differentiation (GO:0001754)4.09121079
29glutamate secretion (GO:0014047)3.97464970
30negative regulation of neurotransmitter transport (GO:0051589)3.97444997
31response to methylmercury (GO:0051597)3.89970193
32dermatan sulfate metabolic process (GO:0030205)3.89808148
33dermatan sulfate biosynthetic process (GO:0030208)3.89003025
34presynaptic membrane organization (GO:0097090)3.83600487
35asymmetric protein localization (GO:0008105)3.78723806
36synaptic vesicle exocytosis (GO:0016079)3.74290997
37astrocyte development (GO:0014002)3.67864724
38neuron cell-cell adhesion (GO:0007158)3.67720479
39apical protein localization (GO:0045176)3.66400223
40positive regulation of oligodendrocyte differentiation (GO:0048714)3.65643816
41astrocyte differentiation (GO:0048708)3.64890311
42amino acid import (GO:0043090)3.64831915
43substantia nigra development (GO:0021762)3.61268884
44cholesterol biosynthetic process (GO:0006695)3.59495302
45cell-cell junction maintenance (GO:0045217)3.55630205
46presynaptic membrane assembly (GO:0097105)3.52955460
47establishment of mitochondrion localization (GO:0051654)3.52679228
48long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.49757164
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.47959989
50negative regulation of catenin import into nucleus (GO:0035414)3.46866177
51glycerophospholipid catabolic process (GO:0046475)3.35367541
52membrane tubulation (GO:0097320)3.35006136
53negative regulation of axonogenesis (GO:0050771)3.32460843
54postsynaptic membrane organization (GO:0001941)3.28445514
55neuron remodeling (GO:0016322)3.28362173
56import into cell (GO:0098657)3.24453084
57regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24238855
58neuronal ion channel clustering (GO:0045161)3.23305185
59adult walking behavior (GO:0007628)3.22636273
60positive regulation of synapse maturation (GO:0090129)3.21982576
61glycine transport (GO:0015816)3.19330780
62transmission of nerve impulse (GO:0019226)3.18728474
63long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.16528286
64exploration behavior (GO:0035640)3.16239884
65neuronal action potential propagation (GO:0019227)3.15886497
66regulation of neuronal synaptic plasticity (GO:0048168)3.15848352
67neuron projection regeneration (GO:0031102)3.15629413
68long-term synaptic potentiation (GO:0060291)3.14169858
69sterol biosynthetic process (GO:0016126)3.13997943
70secondary metabolic process (GO:0019748)3.13226066
71melanin biosynthetic process (GO:0042438)3.11916449
72cellular response to nitric oxide (GO:0071732)3.11864319
73dendritic spine organization (GO:0097061)3.10984835
74regulation of voltage-gated calcium channel activity (GO:1901385)3.10638831
75regulation of synaptic vesicle exocytosis (GO:2000300)3.08538590
76response to dietary excess (GO:0002021)3.08029626
77negative regulation of axon extension (GO:0030517)3.03828876
78regulation of somitogenesis (GO:0014807)3.03691643
79negative regulation of JUN kinase activity (GO:0043508)3.02293067
80fatty-acyl-CoA biosynthetic process (GO:0046949)3.01787762
81pigment biosynthetic process (GO:0046148)3.01775625
82regulation of early endosome to late endosome transport (GO:2000641)3.01265807
83response to redox state (GO:0051775)3.00930666
84layer formation in cerebral cortex (GO:0021819)2.99666697
85amyloid precursor protein metabolic process (GO:0042982)2.98309430
86neurotransmitter-gated ion channel clustering (GO:0072578)2.97438579
87response to lipoprotein particle (GO:0055094)2.97225917
88protein palmitoylation (GO:0018345)2.95900809
89melanosome organization (GO:0032438)2.93686263
90positive regulation of neurological system process (GO:0031646)2.93292614
91dendritic spine morphogenesis (GO:0060997)2.92698169
92axon regeneration (GO:0031103)2.92407369
93potassium ion homeostasis (GO:0055075)2.91666176
94angiogenesis involved in wound healing (GO:0060055)2.89481734
95positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89040000
96locomotory exploration behavior (GO:0035641)2.88992705
97isoprenoid biosynthetic process (GO:0008299)2.86410283
98limb bud formation (GO:0060174)2.84890776
99cerebellar Purkinje cell layer development (GO:0021680)2.83833961
100positive regulation of glial cell differentiation (GO:0045687)2.82723967
101neuromuscular process controlling balance (GO:0050885)2.82225153
102adhesion of symbiont to host cell (GO:0044650)2.81818985
103virion attachment to host cell (GO:0019062)2.81818985
104regulation of protein sumoylation (GO:0033233)2.78667697
105negative regulation of adherens junction organization (GO:1903392)2.78432338
106negative regulation of focal adhesion assembly (GO:0051895)2.78432338
107negative regulation of cell junction assembly (GO:1901889)2.78432338
108* neuroepithelial cell differentiation (GO:0060563)2.77589843
109regulation of synaptic plasticity (GO:0048167)2.76407259
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75830840
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75401494
112pigment granule organization (GO:0048753)2.75190866
113regulation of lipoprotein metabolic process (GO:0050746)2.73572356
114melanin metabolic process (GO:0006582)2.71770128
115iron coordination entity transport (GO:1901678)2.70900208
116negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.70847563
117fatty-acyl-CoA metabolic process (GO:0035337)2.70711477
118axon development (GO:0061564)2.70468899
119synaptic vesicle maturation (GO:0016188)2.69681989
120synaptic vesicle endocytosis (GO:0048488)2.67315524
121cell junction maintenance (GO:0034331)2.66561587
122Leydig cell differentiation (GO:0033327)2.66464036
123regulation of synapse maturation (GO:0090128)2.64786525
124* glial cell differentiation (GO:0010001)2.64248246
125endosome to melanosome transport (GO:0035646)2.62902301
126endosome to pigment granule transport (GO:0043485)2.62902301
127* peripheral nervous system development (GO:0007422)2.62280833
128nerve growth factor signaling pathway (GO:0038180)2.62182978
129cell volume homeostasis (GO:0006884)2.61043306
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59695887
131glial cell migration (GO:0008347)2.59629863
132neuron recognition (GO:0008038)2.59541082
133cellular sodium ion homeostasis (GO:0006883)2.59012238
134cellular response to reactive nitrogen species (GO:1902170)2.58356717
135pigmentation (GO:0043473)2.58323988
136potassium ion import (GO:0010107)2.57954241
137glial cell development (GO:0021782)2.57883376
138dendrite morphogenesis (GO:0048813)2.57851196
139cerebellar granule cell differentiation (GO:0021707)2.56987437
140positive regulation of astrocyte differentiation (GO:0048711)2.56049194
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55027990
142cellular response to epinephrine stimulus (GO:0071872)2.54595588
143cerebral cortex radially oriented cell migration (GO:0021799)2.53239094
144proline transport (GO:0015824)2.52619078
145neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.51332672
146vocalization behavior (GO:0071625)2.50965941
147neurotransmitter uptake (GO:0001504)2.50440908
148protein retention in ER lumen (GO:0006621)2.47245563
149secondary metabolite biosynthetic process (GO:0044550)2.46910883
150positive regulation of actin filament depolymerization (GO:0030836)2.46814969
151neural nucleus development (GO:0048857)2.46469133
152cytoskeletal anchoring at plasma membrane (GO:0007016)2.44661981
153regulation of synaptic vesicle transport (GO:1902803)2.44200150
154negative regulation of execution phase of apoptosis (GO:1900118)2.42305668
155very long-chain fatty acid metabolic process (GO:0000038)2.41978433
156glycosylceramide metabolic process (GO:0006677)2.41501089
157thioester biosynthetic process (GO:0035384)2.41393867
158acyl-CoA biosynthetic process (GO:0071616)2.41393867
159cellular response to catecholamine stimulus (GO:0071870)2.41014172
160cellular response to monoamine stimulus (GO:0071868)2.41014172
161cAMP biosynthetic process (GO:0006171)2.40590303
162magnesium ion transport (GO:0015693)2.39899203
163detection of temperature stimulus involved in sensory perception (GO:0050961)2.39571522
164detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.39571522
165negative regulation of macroautophagy (GO:0016242)2.37011291
166* positive regulation of gliogenesis (GO:0014015)2.35720934
167substrate-independent telencephalic tangential migration (GO:0021826)2.34534036
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.34534036
169peptidyl-cysteine modification (GO:0018198)2.34223558
170regulation of autophagic vacuole assembly (GO:2000785)2.32859946
171adult locomotory behavior (GO:0008344)2.31717039
172axon ensheathment in central nervous system (GO:0032291)11.0810240
173central nervous system myelination (GO:0022010)11.0810240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.83819213
2* LXR_22292898_ChIP-Seq_THP-1_Human3.01770891
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79467070
4EZH2_22144423_ChIP-Seq_EOC_Human2.67011243
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62398608
6KDM2B_26808549_Chip-Seq_K562_Human2.53829631
7GBX2_23144817_ChIP-Seq_PC3_Human2.53785935
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53447366
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53288034
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52436246
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52436246
12* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.47662196
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42376503
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.41337715
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33647128
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30049373
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22464000
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18115355
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16320864
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.15244515
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14167459
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14148431
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.12704154
24* AR_21572438_ChIP-Seq_LNCaP_Human2.11301332
25RACK7_27058665_Chip-Seq_MCF-7_Human2.09746426
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.08572774
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08360170
28EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.00298981
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.99435824
30DROSHA_22980978_ChIP-Seq_HELA_Human1.96517963
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.94316172
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.93796337
33* MITF_21258399_ChIP-Seq_MELANOMA_Human1.91649271
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.88694192
35* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86562665
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84383138
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.83090557
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.81444920
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80092728
40* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77792278
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.76020322
42KDM2B_26808549_Chip-Seq_DND41_Human1.74536016
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74033113
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68365314
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67760298
46TET1_21490601_ChIP-Seq_MESCs_Mouse1.61694579
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60906233
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59831571
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58441609
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57982568
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57158094
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56975572
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.55865236
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53797410
55TAF15_26573619_Chip-Seq_HEK293_Human1.52934019
56* CTCF_27219007_Chip-Seq_Bcells_Human1.51902495
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51634412
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50413475
59* SMC4_20622854_ChIP-Seq_HELA_Human1.47775524
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47011036
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.45706254
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43016139
63ZNF263_19887448_ChIP-Seq_K562_Human1.42999419
64TCF7_22412390_ChIP-Seq_EML_Mouse1.42768502
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41998318
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41193964
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38508866
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.38341082
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.35634414
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.34972391
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34958884
72P68_20966046_ChIP-Seq_HELA_Human1.33712730
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33136059
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.32698597
75TP53_23651856_ChIP-Seq_MEFs_Mouse1.31691338
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30726466
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30714773
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29538329
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29348262
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29137532
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.28720100
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28245840
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27597112
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27466766
85AHR_22903824_ChIP-Seq_MCF-7_Human1.26032950
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.26020722
87VDR_21846776_ChIP-Seq_THP-1_Human1.25830162
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25516203
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25296830
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.25012475
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25007696
92CLOCK_20551151_ChIP-Seq_293T_Human1.24698224
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22893403
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22645761
95ER_23166858_ChIP-Seq_MCF-7_Human1.22630883
96REST_21632747_ChIP-Seq_MESCs_Mouse1.21497318
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20491339
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.19064803
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.18551343
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.18267605
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.18267605
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.17945011
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17896000
104* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17776148
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.15360774
106SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14118618
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14100944
108CREB1_26743006_Chip-Seq_LNCaP_Human1.13663804
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13458404
110ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13427377
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12205985
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11448151
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11448151
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11159013
115OCT4_19829295_ChIP-Seq_ESCs_Human1.10954848
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10581485
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10339286
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07671926
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.07416550
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02223546
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01537959
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01240196
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00886505
124TP53_22127205_ChIP-Seq_IMR90_Human1.00809442
125* TP63_22573176_ChIP-Seq_HFKS_Human1.00210883
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99375507
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99324610
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99125565
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99009384
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.98462639
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.98147803
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96930911
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95363960
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95084412
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94842628
136STAT3_23295773_ChIP-Seq_U87_Human0.94656781
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93918068
138P300_19829295_ChIP-Seq_ESCs_Human0.92773441
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92362320
140EOMES_21245162_ChIP-Seq_HESCs_Human0.91491371
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91041579
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90816576
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.90749649
144SMAD4_21799915_ChIP-Seq_A2780_Human0.89770021
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89146701
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88617144
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.88103624
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87904513
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85999742
150EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85223079
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85127129
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84873559
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.84215030
154TCF4_23295773_ChIP-Seq_U87_Human0.83518284
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.83159154
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82888789
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81626737
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.81569186
159SMAD3_21741376_ChIP-Seq_ESCs_Human0.81285474
160P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81275205
161PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79376289
162LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78883752
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.78239844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.14766864
2MP0000015_abnormal_ear_pigmentation4.26935702
3MP0003880_abnormal_central_pattern3.97793344
4* MP0005408_hypopigmentation3.63757350
5MP0003136_yellow_coat_color3.58931994
6MP0004885_abnormal_endolymph3.55170726
7MP0002877_abnormal_melanocyte_morpholog3.21384825
8MP0004270_analgesia3.07005145
9MP0003690_abnormal_glial_cell3.04845609
10MP0005257_abnormal_intraocular_pressure2.99824202
11MP0002095_abnormal_skin_pigmentation2.98391686
12* MP0005075_abnormal_melanosome_morpholog2.88725799
13MP0000569_abnormal_digit_pigmentation2.86106972
14MP0005174_abnormal_tail_pigmentation2.85272690
15MP0000371_diluted_coat_color2.84513375
16MP0003950_abnormal_plasma_membrane2.71095773
17MP0004742_abnormal_vestibular_system2.67884502
18MP0004859_abnormal_synaptic_plasticity2.65370004
19MP0003329_amyloid_beta_deposits2.59897216
20MP0001486_abnormal_startle_reflex2.52647773
21MP0001485_abnormal_pinna_reflex2.50407042
22* MP0002272_abnormal_nervous_system2.46921161
23* MP0003634_abnormal_glial_cell2.46779917
24MP0002064_seizures2.20575506
25MP0000778_abnormal_nervous_system2.17253139
26* MP0002075_abnormal_coat/hair_pigmentati2.13031203
27MP0004142_abnormal_muscle_tone2.10631180
28MP0001529_abnormal_vocalization2.10223579
29MP0000372_irregular_coat_pigmentation2.04098683
30MP0005423_abnormal_somatic_nervous2.03601224
31MP0003635_abnormal_synaptic_transmissio1.96270138
32MP0003632_abnormal_nervous_system1.85445313
33MP0010678_abnormal_skin_adnexa1.80454978
34MP0002734_abnormal_mechanical_nocicepti1.79734875
35MP0009745_abnormal_behavioral_response1.78753028
36MP0005623_abnormal_meninges_morphology1.78019688
37* MP0001186_pigmentation_phenotype1.77534623
38MP0001905_abnormal_dopamine_level1.75740617
39* MP0005171_absent_coat_pigmentation1.75284287
40MP0002229_neurodegeneration1.74706961
41MP0005409_darkened_coat_color1.71765057
42MP0001324_abnormal_eye_pigmentation1.67604853
43MP0000955_abnormal_spinal_cord1.62648065
44MP0000462_abnormal_digestive_system1.59983953
45MP0001299_abnormal_eye_distance/1.54549378
46MP0009046_muscle_twitch1.53930362
47MP0002089_abnormal_postnatal_growth/wei1.47421188
48MP0001963_abnormal_hearing_physiology1.45639668
49MP0004134_abnormal_chest_morphology1.44278186
50* MP0002882_abnormal_neuron_morphology1.43237398
51MP0003631_nervous_system_phenotype1.41917879
52MP0000383_abnormal_hair_follicle1.39547108
53MP0002063_abnormal_learning/memory/cond1.37445935
54MP0002572_abnormal_emotion/affect_behav1.35680220
55MP0002067_abnormal_sensory_capabilities1.32216079
56MP0005248_abnormal_Harderian_gland1.31844296
57MP0000762_abnormal_tongue_morphology1.30309208
58MP0000747_muscle_weakness1.30078515
59MP0003633_abnormal_nervous_system1.25365102
60MP0000604_amyloidosis1.24650778
61MP0001970_abnormal_pain_threshold1.22818816
62* MP0002066_abnormal_motor_capabilities/c1.22230878
63MP0005410_abnormal_fertilization1.21662347
64MP0001968_abnormal_touch/_nociception1.21314973
65* MP0008569_lethality_at_weaning1.17422614
66MP0001849_ear_inflammation1.15186423
67* MP0002752_abnormal_somatic_nervous1.14937520
68MP0004043_abnormal_pH_regulation1.12548523
69MP0005551_abnormal_eye_electrophysiolog1.12387381
70MP0008438_abnormal_cutaneous_collagen1.10757093
71MP0002733_abnormal_thermal_nociception1.10349138
72MP0000566_synostosis1.10259157
73MP0000026_abnormal_inner_ear1.09905595
74MP0001346_abnormal_lacrimal_gland1.09134825
75MP0001440_abnormal_grooming_behavior1.07008948
76MP0001177_atelectasis1.05887589
77MP0008260_abnormal_autophagy1.05340897
78MP0004858_abnormal_nervous_system1.04528528
79MP0005377_hearing/vestibular/ear_phenot1.03176359
80MP0003878_abnormal_ear_physiology1.03176359
81MP0004272_abnormal_basement_membrane1.03095803
82MP0003705_abnormal_hypodermis_morpholog1.01931982
83MP0005386_behavior/neurological_phenoty1.00845664
84MP0004924_abnormal_behavior1.00845664
85MP0000467_abnormal_esophagus_morphology0.98073173
86MP0000579_abnormal_nail_morphology0.96856060
87MP0002184_abnormal_innervation0.94078696
88MP0010030_abnormal_orbit_morphology0.90455345
89MP0003938_abnormal_ear_development0.89913833
90MP0002152_abnormal_brain_morphology0.89740203
91MP0005195_abnormal_posterior_eye0.81970970
92MP0002249_abnormal_larynx_morphology0.81309393
93MP0009384_cardiac_valve_regurgitation0.80870091
94MP0000647_abnormal_sebaceous_gland0.80607328
95MP0001348_abnormal_lacrimal_gland0.80521605
96MP0002090_abnormal_vision0.79189975
97MP0005197_abnormal_uvea_morphology0.78887268
98MP0002557_abnormal_social/conspecific_i0.78688110
99MP0001188_hyperpigmentation0.78365499
100MP0001502_abnormal_circadian_rhythm0.78364151
101MP0002736_abnormal_nociception_after0.77524853
102* MP0004811_abnormal_neuron_physiology0.73618818
103MP0002822_catalepsy0.73337684
104MP0004145_abnormal_muscle_electrophysio0.73322521
105* MP0004381_abnormal_hair_follicle0.73254836
106MP0003172_abnormal_lysosome_physiology0.73222349
107MP0000733_abnormal_muscle_development0.71291523
108MP0001958_emphysema0.71010547
109MP0000003_abnormal_adipose_tissue0.70790755
110MP0001661_extended_life_span0.70506858
111MP0002653_abnormal_ependyma_morphology0.70296854
112MP0003123_paternal_imprinting0.70236468
113MP0010234_abnormal_vibrissa_follicle0.69578192
114MP0005451_abnormal_body_composition0.69409294
115MP0002060_abnormal_skin_morphology0.68921081
116MP0009250_abnormal_appendicular_skeleto0.68144452
117MP0005253_abnormal_eye_physiology0.67343419
118* MP0002938_white_spotting0.67209798
119MP0001943_abnormal_respiration0.67056234
120MP0005058_abnormal_lysosome_morphology0.66769941
121MP0003937_abnormal_limbs/digits/tail_de0.66579263
122MP0000534_abnormal_ureter_morphology0.65847028
123MP0001340_abnormal_eyelid_morphology0.65564459
124MP0001984_abnormal_olfaction0.64650137
125MP0001851_eye_inflammation0.64575704
126MP0000751_myopathy0.63355682
127MP0003453_abnormal_keratinocyte_physiol0.63283726
128MP0005670_abnormal_white_adipose0.63191001
129MP0003091_abnormal_cell_migration0.59582432
130MP0005167_abnormal_blood-brain_barrier0.57837592
131MP0003279_aneurysm0.56098623
132MP0006138_congestive_heart_failure0.54105520
133MP0003075_altered_response_to0.52697478
134MP0002735_abnormal_chemical_nociception0.50079765
135MP0002177_abnormal_outer_ear0.49661348
136MP0005508_abnormal_skeleton_morphology0.46271748
137* MP0000367_abnormal_coat/_hair0.44902196
138MP0003879_abnormal_hair_cell0.44819048
139MP0005646_abnormal_pituitary_gland0.44334200
140MP0001501_abnormal_sleep_pattern0.43864595
141MP0003385_abnormal_body_wall0.43485870
142MP0009780_abnormal_chondrocyte_physiolo0.41859659

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.10502962
2* Ocular albinism (HP:0001107)6.04029217
3* White forelock (HP:0002211)6.02003547
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.92629924
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.92629924
6Aplasia/Hypoplasia of the macula (HP:0008059)5.59403296
7Hypoplasia of the fovea (HP:0007750)5.50793918
8Aplasia/Hypoplasia of the fovea (HP:0008060)5.50793918
9* Patchy hypopigmentation of hair (HP:0011365)5.28242204
10* Iris hypopigmentation (HP:0007730)5.27089165
11Aplasia/Hypoplasia affecting the retina (HP:0008061)5.23581370
12* Blue irides (HP:0000635)5.22133335
13Onion bulb formation (HP:0003383)4.83546903
14Abnormality of the corticospinal tract (HP:0002492)4.53545873
15Cerebral inclusion bodies (HP:0100314)4.50870762
16Segmental peripheral demyelination/remyelination (HP:0003481)4.48250669
17Abnormality of the fovea (HP:0000493)4.47707692
18Insidious onset (HP:0003587)4.41091698
19Termporal pattern (HP:0011008)4.41091698
20Supranuclear gaze palsy (HP:0000605)4.20873580
21Sensory axonal neuropathy (HP:0003390)4.13571208
22Obstructive sleep apnea (HP:0002870)4.07873988
23Cerebral aneurysm (HP:0004944)4.01086941
24Hand muscle atrophy (HP:0009130)3.94078404
25* Hypopigmentation of the fundus (HP:0007894)3.76959801
26Ankle clonus (HP:0011448)3.75796262
27Distal upper limb amyotrophy (HP:0007149)3.73769683
28Upper limb amyotrophy (HP:0009129)3.73769683
29* Heterochromia iridis (HP:0001100)3.57563176
30Myokymia (HP:0002411)3.55916148
31J-shaped sella turcica (HP:0002680)3.49476104
32Parakeratosis (HP:0001036)3.47515580
33Spastic gait (HP:0002064)3.44378707
34Generalized hypopigmentation (HP:0007513)3.40654967
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.36621353
36Intention tremor (HP:0002080)3.34742117
37Action tremor (HP:0002345)3.27012907
38Dysmetria (HP:0001310)3.24404686
39* Peripheral hypomyelination (HP:0007182)3.19772604
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.17842536
41Absent epiphyses (HP:0010577)3.17842536
42Upper limb muscle weakness (HP:0003484)3.10081371
43Shallow orbits (HP:0000586)3.09345350
44Premature skin wrinkling (HP:0100678)3.00454063
45* Cerebral hypomyelination (HP:0006808)2.95001393
46Slow saccadic eye movements (HP:0000514)2.92575661
47Akinesia (HP:0002304)2.91611683
48Retinal dysplasia (HP:0007973)2.87207228
49Hypoplastic pelvis (HP:0008839)2.86956781
50Ulnar claw (HP:0001178)2.83598451
51Scanning speech (HP:0002168)2.80802654
52* Abnormal auditory evoked potentials (HP:0006958)2.79472493
53Foot dorsiflexor weakness (HP:0009027)2.73399718
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.69948364
55Vertebral compression fractures (HP:0002953)2.58065491
56Axonal loss (HP:0003447)2.55968863
57Aplasia involving bones of the extremities (HP:0009825)2.49296621
58Aplasia involving bones of the upper limbs (HP:0009823)2.49296621
59Aplasia of the phalanges of the hand (HP:0009802)2.49296621
60Abnormality of the foot musculature (HP:0001436)2.48317704
61Megalencephaly (HP:0001355)2.47058289
62Decreased motor nerve conduction velocity (HP:0003431)2.47015113
63Hammertoe (HP:0001765)2.46934751
64Esophageal atresia (HP:0002032)2.46475410
65Annular pancreas (HP:0001734)2.44961862
66Humeroradial synostosis (HP:0003041)2.38754206
67Synostosis involving the elbow (HP:0003938)2.38754206
68Coronal craniosynostosis (HP:0004440)2.36186820
69Clumsiness (HP:0002312)2.35858012
70Protrusio acetabuli (HP:0003179)2.35737063
71Absent septum pellucidum (HP:0001331)2.33772837
72Albinism (HP:0001022)2.31610349
73Split foot (HP:0001839)2.30976484
74Pheochromocytoma (HP:0002666)2.29932923
75Spastic tetraparesis (HP:0001285)2.28986721
76Stridor (HP:0010307)2.28677809
77Hyperacusis (HP:0010780)2.25803369
78Thickened helices (HP:0000391)2.25731441
79Lower limb muscle weakness (HP:0007340)2.25092521
80Urinary urgency (HP:0000012)2.22912186
81* Premature graying of hair (HP:0002216)2.22890461
82Congenital sensorineural hearing impairment (HP:0008527)2.20857705
83* Leukodystrophy (HP:0002415)2.15267183
84Distal lower limb muscle weakness (HP:0009053)2.14695476
85Increased circulating renin level (HP:0000848)2.13744978
86Epiphyseal dysplasia (HP:0002656)2.13668383
87Clonus (HP:0002169)2.12625220
88Mixed hearing impairment (HP:0000410)2.12616972
89Bell-shaped thorax (HP:0001591)2.12286298
90Limb dystonia (HP:0002451)2.11058065
91Deformed sella turcica (HP:0002681)2.10620013
92Muscle fiber splitting (HP:0003555)2.09058952
93Poor speech (HP:0002465)2.08525028
94Congenital ichthyosiform erythroderma (HP:0007431)2.07774580
95Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05043727
96Bowel incontinence (HP:0002607)2.03803934
97Sleep apnea (HP:0010535)2.01736490
98Abnormality of the middle phalanges of the toes (HP:0010183)2.01586513
99Anteriorly placed anus (HP:0001545)2.01514396
100Gowers sign (HP:0003391)2.01449353
101Steppage gait (HP:0003376)2.00998598
102Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.00853352
103Lower limb amyotrophy (HP:0007210)1.99705193
104Insomnia (HP:0100785)1.99450311
105Ulnar bowing (HP:0003031)1.98308458
106Freckling (HP:0001480)1.98092842
107Truncal ataxia (HP:0002078)1.97923430
108Infantile muscular hypotonia (HP:0008947)1.97221899
109Achilles tendon contracture (HP:0001771)1.96652032
110Choreoathetosis (HP:0001266)1.96294958
111Increased connective tissue (HP:0009025)1.94941300
112Focal motor seizures (HP:0011153)1.94369915
113Cerebral hemorrhage (HP:0001342)1.94096266
114Hypomagnesemia (HP:0002917)1.92260279
115* CNS hypomyelination (HP:0003429)1.91285387
116Generalized hypopigmentation of hair (HP:0011358)1.90021399
117Septo-optic dysplasia (HP:0100842)1.89086107
118Abnormality of the septum pellucidum (HP:0007375)1.89023326
119* Distal sensory impairment (HP:0002936)1.87266562
120Cupped ear (HP:0000378)1.86980760
121Abnormality of binocular vision (HP:0011514)1.86905088
122Diplopia (HP:0000651)1.86905088
123Abnormal large intestine physiology (HP:0012700)1.86858063
124Increased serum pyruvate (HP:0003542)1.86768968
125Abnormality of glycolysis (HP:0004366)1.86768968
126Neuroendocrine neoplasm (HP:0100634)1.85179688
127Hypoplastic ischia (HP:0003175)1.84932523
128Hyporeflexia of lower limbs (HP:0002600)1.80693344
129Scapular winging (HP:0003691)1.80364832
130* Peripheral demyelination (HP:0011096)1.79767270
131Distal lower limb amyotrophy (HP:0008944)1.78849016
132Chin dimple (HP:0010751)1.78387029
133Urinary incontinence (HP:0000020)1.77866640
134Metabolic alkalosis (HP:0200114)1.76485337
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.75765047
136Abnormality of glycolipid metabolism (HP:0010969)1.75765047
137Abnormality of liposaccharide metabolism (HP:0010968)1.75765047
138Partial agenesis of the corpus callosum (HP:0001338)1.74735455
139Autoamputation (HP:0001218)1.73612989
140Premature rupture of membranes (HP:0001788)1.73360847
141Visual hallucinations (HP:0002367)1.73069978
142Postural instability (HP:0002172)1.71900184
143Turricephaly (HP:0000262)1.71643458
144Diaphragmatic weakness (HP:0009113)1.70568613
145Postural tremor (HP:0002174)1.70475813
146Abnormality of the vitreous humor (HP:0004327)1.69385196
147* Paraparesis (HP:0002385)1.68899232
148Bilateral sensorineural hearing impairment (HP:0008619)1.68863315
149Barrel-shaped chest (HP:0001552)1.67812556
150* Alacrima (HP:0000522)1.67750296
151Abnormal pupillary function (HP:0007686)1.67740293
152Torticollis (HP:0000473)1.67090296
153Morphological abnormality of the pyramidal tract (HP:0002062)1.66811968
154* Hypoplasia of the iris (HP:0007676)1.66667223
155Hypokalemic alkalosis (HP:0001949)1.66593852
156Abnormality of vision evoked potentials (HP:0000649)1.66499927
157Difficulty walking (HP:0002355)1.66306410
158Neuronal loss in central nervous system (HP:0002529)1.66030664
159Abnormality of the Achilles tendon (HP:0005109)1.65393592
160Abnormality of the distal phalanges of the toes (HP:0010182)1.64828995
161Abnormality of the ischium (HP:0003174)1.64072365
162Pointed chin (HP:0000307)1.62863986
163Hypoventilation (HP:0002791)1.62217452
164Bulbar palsy (HP:0001283)1.61896020
165Broad face (HP:0000283)1.61017298
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.60930631
167Abnormality of the musculature of the hand (HP:0001421)1.60759699
168Mild short stature (HP:0003502)1.60605025
169Diminished movement (HP:0002374)1.60420046
170Apathy (HP:0000741)1.60329545
171Supernumerary nipples (HP:0002558)1.60236648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.89744954
2LMTK23.89325105
3EPHB13.65360124
4OXSR13.62079662
5RIPK12.89409168
6TRIB32.81998531
7WNK42.77374500
8PKN12.72711618
9MET2.47520029
10LIMK12.34041029
11BCR2.11609704
12TYRO32.06592779
13UHMK12.02971709
14MAPKAPK52.02191271
15CASK2.01973453
16ICK1.93842492
17NTRK11.90439259
18CDK191.89146664
19FGFR21.87202931
20WEE11.86698093
21WNK11.84129091
22TNIK1.73228797
23PBK1.67456772
24MAP3K31.66896273
25CSNK1G31.59965681
26ROCK21.58570099
27CSNK1A1L1.58040417
28PAK41.57720703
29NEK61.57303167
30EEF2K1.55140224
31PDGFRA1.54252181
32CAMK2B1.49879211
33PAK61.47931008
34SGK2231.46509520
35SGK4941.46509520
36TESK21.41606239
37MAP3K111.39704020
38NME21.37683213
39DDR21.37214588
40CSNK1G11.34711636
41PRKD21.29164728
42PNCK1.26906338
43EPHA41.23796637
44CSNK1G21.23070771
45TESK11.22041186
46MAP3K61.20186122
47CAMK2D1.20145771
48IRAK21.18035574
49PRPF4B1.16478728
50KSR21.15806140
51PHKG11.13856203
52PHKG21.13856203
53SIK21.11322962
54MARK31.10262262
55CLK11.06946067
56PRKD31.05324935
57LATS21.04885431
58MARK11.03934422
59PKN21.03334481
60CDK121.00744502
61FGR0.99632267
62BMX0.98678410
63SMG10.96735194
64MARK20.95661749
65CAMK2G0.95066347
66MAP3K20.94961005
67CDK50.94218411
68CAMKK10.94157141
69DAPK20.93545898
70MST40.92218070
71PTK60.91971474
72PAK30.90898579
73PRKD10.88042835
74MST1R0.85633576
75ERN10.85147416
76DYRK20.82856536
77CDK140.82836128
78SIK10.82208303
79IRAK10.81963612
80NTRK30.80801167
81SGK30.77505297
82STK380.76583991
83CAMK2A0.76576712
84MAPK120.75885351
85EPHA20.74778556
86MAPK150.74266385
87FGFR40.71450410
88RPS6KA20.71431134
89CAMK1G0.70628397
90PDGFRB0.70378007
91GSK3A0.69779477
92CDK150.69608139
93PRKCE0.69464349
94TNK20.68510953
95MAPK100.68200501
96FES0.67374260
97PIK3CA0.67277952
98PDPK10.67253792
99PRKCQ0.67135770
100TRPM70.66596795
101NTRK20.66566556
102MTOR0.65466787
103MAPK130.64329924
104CDK180.63669152
105RET0.62107162
106FYN0.61082528
107CDK11A0.60660981
108MAP3K90.60560370
109CDK30.59805584
110MAP3K130.59556903
111MUSK0.59062179
112PTK2B0.55671507
113PRKCH0.54815183
114SGK20.54164941
115EPHA30.53975513
116DAPK10.53240330
117ERBB40.52759873
118DAPK30.49953960
119ARAF0.49624766
120SIK30.49377137
121DMPK0.48718546
122MAPK70.47770703
123AKT20.47496797
124ERBB20.46230252
125CDC42BPA0.44453040
126CSNK1D0.44326720
127FER0.43555931
128PLK20.42419597
129ROCK10.41451199
130BRSK10.41270278
131CSNK1A10.40074586
132PRKCG0.39368984
133ILK0.38845045
134DYRK1A0.38811074
135PDK10.37408035
136HIPK20.37195700
137STK110.36750431
138PAK20.36058639
139MAP3K10.35625841
140PRKG10.34756395
141PAK10.33541484
142MINK10.33264108
143PTK20.32217099
144PRKCZ0.32157384
145INSR0.32082737

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.74983985
2Steroid biosynthesis_Homo sapiens_hsa001003.66843311
3Fatty acid elongation_Homo sapiens_hsa000623.48300881
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66234210
5Nitrogen metabolism_Homo sapiens_hsa009102.58468092
6Ether lipid metabolism_Homo sapiens_hsa005652.49444251
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27238389
8Axon guidance_Homo sapiens_hsa043602.24895526
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93590367
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91307179
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76968708
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70224071
13Sulfur metabolism_Homo sapiens_hsa009201.68491750
14Vitamin B6 metabolism_Homo sapiens_hsa007501.63724442
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.61955401
16Glioma_Homo sapiens_hsa052141.60767099
17Glutamatergic synapse_Homo sapiens_hsa047241.57886082
18Notch signaling pathway_Homo sapiens_hsa043301.53006389
19GABAergic synapse_Homo sapiens_hsa047271.49300179
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48931387
21Other glycan degradation_Homo sapiens_hsa005111.45417867
22Renal cell carcinoma_Homo sapiens_hsa052111.43799851
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.39861215
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38375747
25Tight junction_Homo sapiens_hsa045301.28517425
26Vibrio cholerae infection_Homo sapiens_hsa051101.28208315
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28056332
28Sphingolipid metabolism_Homo sapiens_hsa006001.26726046
29Collecting duct acid secretion_Homo sapiens_hsa049661.26435616
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26078240
31Long-term depression_Homo sapiens_hsa047301.24739451
32Inositol phosphate metabolism_Homo sapiens_hsa005621.21945282
33Serotonergic synapse_Homo sapiens_hsa047261.19552802
34VEGF signaling pathway_Homo sapiens_hsa043701.18484969
35Synaptic vesicle cycle_Homo sapiens_hsa047211.16681788
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.14156206
37Fatty acid biosynthesis_Homo sapiens_hsa000611.12713209
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11565232
39Oxidative phosphorylation_Homo sapiens_hsa001901.10606924
40Cocaine addiction_Homo sapiens_hsa050301.10363486
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10026094
42Morphine addiction_Homo sapiens_hsa050321.09726338
43Linoleic acid metabolism_Homo sapiens_hsa005911.08058489
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07622488
45Salivary secretion_Homo sapiens_hsa049701.05033014
46Histidine metabolism_Homo sapiens_hsa003401.04520596
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04478357
48Endometrial cancer_Homo sapiens_hsa052131.03370305
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03336724
50Bile secretion_Homo sapiens_hsa049761.03195779
51Gastric acid secretion_Homo sapiens_hsa049711.02863539
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.00476907
53ErbB signaling pathway_Homo sapiens_hsa040121.00189543
54Circadian entrainment_Homo sapiens_hsa047130.99451289
55Endocytosis_Homo sapiens_hsa041440.97403938
56Butanoate metabolism_Homo sapiens_hsa006500.97086865
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96857004
58Cholinergic synapse_Homo sapiens_hsa047250.95051954
59ECM-receptor interaction_Homo sapiens_hsa045120.94321668
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93863910
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.93665806
62Calcium signaling pathway_Homo sapiens_hsa040200.90727722
63Protein export_Homo sapiens_hsa030600.90101475
64Non-small cell lung cancer_Homo sapiens_hsa052230.89400683
65Adherens junction_Homo sapiens_hsa045200.88596795
66Thyroid cancer_Homo sapiens_hsa052160.87505371
67Protein digestion and absorption_Homo sapiens_hsa049740.87467471
68Dopaminergic synapse_Homo sapiens_hsa047280.87221708
69Hedgehog signaling pathway_Homo sapiens_hsa043400.86534756
70Gap junction_Homo sapiens_hsa045400.86332941
71Insulin signaling pathway_Homo sapiens_hsa049100.85119196
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84957064
73mTOR signaling pathway_Homo sapiens_hsa041500.84862774
74Melanogenesis_Homo sapiens_hsa049160.83888942
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83438063
76Lysine degradation_Homo sapiens_hsa003100.82446775
77Ras signaling pathway_Homo sapiens_hsa040140.80209779
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79936961
79Alzheimers disease_Homo sapiens_hsa050100.79842191
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.78070983
81Chronic myeloid leukemia_Homo sapiens_hsa052200.74265757
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72743909
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.72218782
84Nicotine addiction_Homo sapiens_hsa050330.70962330
85Acute myeloid leukemia_Homo sapiens_hsa052210.70313266
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69759999
87Lysosome_Homo sapiens_hsa041420.69756392
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69375028
89Rap1 signaling pathway_Homo sapiens_hsa040150.69353578
90Thyroid hormone synthesis_Homo sapiens_hsa049180.69045272
91AMPK signaling pathway_Homo sapiens_hsa041520.68807647
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68455322
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68029812
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68005364
95Cardiac muscle contraction_Homo sapiens_hsa042600.67811879
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66619319
97Arginine and proline metabolism_Homo sapiens_hsa003300.66411295
98MicroRNAs in cancer_Homo sapiens_hsa052060.66275233
99Parkinsons disease_Homo sapiens_hsa050120.64015687
100Small cell lung cancer_Homo sapiens_hsa052220.64011583
101Renin secretion_Homo sapiens_hsa049240.62207762
102Tyrosine metabolism_Homo sapiens_hsa003500.61616808
103Amphetamine addiction_Homo sapiens_hsa050310.61611017
104Fatty acid metabolism_Homo sapiens_hsa012120.61604175
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61336293
106Choline metabolism in cancer_Homo sapiens_hsa052310.59725696
107Prion diseases_Homo sapiens_hsa050200.59348848
108Olfactory transduction_Homo sapiens_hsa047400.57842191
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57298723
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56870535
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56689340
112Prostate cancer_Homo sapiens_hsa052150.56392910
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55887301
114Rheumatoid arthritis_Homo sapiens_hsa053230.55860590
115Pancreatic secretion_Homo sapiens_hsa049720.55436534
116Long-term potentiation_Homo sapiens_hsa047200.55075161
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54213282
118Melanoma_Homo sapiens_hsa052180.50975727
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.50532454
120Glucagon signaling pathway_Homo sapiens_hsa049220.50141138
121Oxytocin signaling pathway_Homo sapiens_hsa049210.49900173
122Ovarian steroidogenesis_Homo sapiens_hsa049130.49661069
123Dilated cardiomyopathy_Homo sapiens_hsa054140.48697472
124Phagosome_Homo sapiens_hsa041450.47939183
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47841257
126Focal adhesion_Homo sapiens_hsa045100.47554558
127cAMP signaling pathway_Homo sapiens_hsa040240.47325837
128Insulin resistance_Homo sapiens_hsa049310.46840570
129Oocyte meiosis_Homo sapiens_hsa041140.46583118
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46550963
131GnRH signaling pathway_Homo sapiens_hsa049120.43782229
132Hippo signaling pathway_Homo sapiens_hsa043900.41916640
133MAPK signaling pathway_Homo sapiens_hsa040100.41420542
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41153569
135Taste transduction_Homo sapiens_hsa047420.40812709
136Phototransduction_Homo sapiens_hsa047440.39316156
137Insulin secretion_Homo sapiens_hsa049110.39169571
138Wnt signaling pathway_Homo sapiens_hsa043100.39075250
139Estrogen signaling pathway_Homo sapiens_hsa049150.38511196
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38244977
141Mineral absorption_Homo sapiens_hsa049780.37768902
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37428058

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »