SOX12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.16712343
2peptidyl-arginine omega-N-methylation (GO:0035247)3.98767073
3planar cell polarity pathway involved in neural tube closure (GO:0090179)3.93453500
4paraxial mesoderm development (GO:0048339)3.90888410
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.68512097
6peptidyl-arginine methylation (GO:0018216)3.68304890
7peptidyl-arginine N-methylation (GO:0035246)3.68304890
8pyrimidine nucleobase catabolic process (GO:0006208)3.65242322
9histone arginine methylation (GO:0034969)3.42730404
10negative regulation of catenin import into nucleus (GO:0035414)3.39856945
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37171021
12postsynaptic membrane organization (GO:0001941)3.32550247
13pre-miRNA processing (GO:0031054)3.30590764
14nucleosome disassembly (GO:0006337)3.28533200
15protein-DNA complex disassembly (GO:0032986)3.28533200
16proximal/distal pattern formation (GO:0009954)3.24996695
17polarized epithelial cell differentiation (GO:0030859)3.24614324
18lateral sprouting from an epithelium (GO:0060601)3.18209028
19establishment or maintenance of monopolar cell polarity (GO:0061339)3.16081919
20establishment of monopolar cell polarity (GO:0061162)3.16081919
21layer formation in cerebral cortex (GO:0021819)3.15167644
22body morphogenesis (GO:0010171)3.11354754
23negative regulation of RNA splicing (GO:0033119)2.98717350
24central nervous system projection neuron axonogenesis (GO:0021952)2.96503312
25spliceosomal tri-snRNP complex assembly (GO:0000244)2.96070755
26cell-cell junction maintenance (GO:0045217)2.92575057
27presynaptic membrane assembly (GO:0097105)2.92170370
28negative regulation of mRNA processing (GO:0050686)2.90911841
29mitochondrion transport along microtubule (GO:0047497)2.87994656
30establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87994656
31establishment of apical/basal cell polarity (GO:0035089)2.87815689
32head development (GO:0060322)2.86274139
33gonadal mesoderm development (GO:0007506)2.82329075
34ribosomal small subunit biogenesis (GO:0042274)2.81917448
35cochlea morphogenesis (GO:0090103)2.79603878
36cell proliferation in forebrain (GO:0021846)2.77528091
37viral transcription (GO:0019083)2.73930681
38hippo signaling (GO:0035329)2.70456099
39embryonic body morphogenesis (GO:0010172)2.70080867
40cranial nerve morphogenesis (GO:0021602)2.69736308
41L-serine metabolic process (GO:0006563)2.68337230
42establishment of planar polarity (GO:0001736)2.68191170
43establishment of tissue polarity (GO:0007164)2.68191170
44regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67068585
45axonal fasciculation (GO:0007413)2.66883101
46convergent extension (GO:0060026)2.66840232
47metanephric mesenchyme development (GO:0072075)2.66285979
48regulation of posttranscriptional gene silencing (GO:0060147)2.66031896
49regulation of gene silencing by miRNA (GO:0060964)2.66031896
50regulation of gene silencing by RNA (GO:0060966)2.66031896
51establishment of mitochondrion localization (GO:0051654)2.62098395
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61185781
53dendritic spine morphogenesis (GO:0060997)2.60871131
54translational termination (GO:0006415)2.60535876
55kidney mesenchyme development (GO:0072074)2.60469427
56embryonic foregut morphogenesis (GO:0048617)2.60178774
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59505462
58positive regulation of gastrulation (GO:2000543)2.58752376
59* spinal cord development (GO:0021510)2.57989667
60negative regulation of DNA repair (GO:0045738)2.57538336
61axon extension involved in axon guidance (GO:0048846)2.56585541
62neuron projection extension involved in neuron projection guidance (GO:1902284)2.56585541
63hindlimb morphogenesis (GO:0035137)2.56143083
64mesenchymal to epithelial transition (GO:0060231)2.55605937
65intracellular estrogen receptor signaling pathway (GO:0030520)2.54299047
66urogenital system development (GO:0001655)2.54193655
67regulation of hippo signaling (GO:0035330)2.54008316
68regulation of NFAT protein import into nucleus (GO:0051532)2.53398158
69regulation of establishment of planar polarity (GO:0090175)2.51754828
70mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.51304909
71DNA damage response, detection of DNA damage (GO:0042769)2.51027691
72presynaptic membrane organization (GO:0097090)2.50641942
73outer ear morphogenesis (GO:0042473)2.49199898
74embryonic hindlimb morphogenesis (GO:0035116)2.47490734
75cardiac myofibril assembly (GO:0055003)2.45022973
76negative regulation of mRNA metabolic process (GO:1903312)2.44795145
77DNA unwinding involved in DNA replication (GO:0006268)2.42472255
78negative regulation of organelle assembly (GO:1902116)2.41382433
79gastrulation with mouth forming second (GO:0001702)2.40778308
80neuron recognition (GO:0008038)2.40526953
81non-canonical Wnt signaling pathway (GO:0035567)2.40175039
82pituitary gland development (GO:0021983)2.37736951
83nucleobase catabolic process (GO:0046113)2.35888618
84heterochromatin organization (GO:0070828)2.35161539
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35007306
86regulation of stem cell maintenance (GO:2000036)2.34178295
87protein localization to synapse (GO:0035418)2.34131275
88mesenchymal cell proliferation (GO:0010463)2.32563484
89mesenchyme development (GO:0060485)2.32115514
90atrial cardiac muscle cell action potential (GO:0086014)2.31919033
91cell junction maintenance (GO:0034331)2.31875693
92positive regulation of dendritic spine morphogenesis (GO:0061003)2.31548980
93spliceosomal complex assembly (GO:0000245)2.31407933
94positive regulation of dendrite morphogenesis (GO:0050775)2.29900352
95regulation of DNA damage checkpoint (GO:2000001)2.29651515
96neuron cell-cell adhesion (GO:0007158)2.29305601
97positive regulation of RNA splicing (GO:0033120)2.28161147
98notochord development (GO:0030903)2.28149727
99negative regulation of axon extension involved in axon guidance (GO:0048843)2.27798979
100camera-type eye morphogenesis (GO:0048593)2.27166788
101RNA localization (GO:0006403)2.27127829
102lens fiber cell development (GO:0070307)2.26217836
103limb bud formation (GO:0060174)2.26125825
104establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25734839
105regulation of translational fidelity (GO:0006450)2.24454656
106atrial septum morphogenesis (GO:0060413)2.24361958
107adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.24350318
108neural tube development (GO:0021915)2.23409825
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.23322048
110central nervous system neuron axonogenesis (GO:0021955)2.23320952
111translational elongation (GO:0006414)2.23096798
112mRNA splice site selection (GO:0006376)2.22228582
113chromatin assembly (GO:0031497)2.21084546
114ribosomal small subunit assembly (GO:0000028)2.20646756
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.19883735
116mesenchyme morphogenesis (GO:0072132)2.18944234
117facial nerve structural organization (GO:0021612)2.17766486
118stress granule assembly (GO:0034063)2.17565783
119axon extension (GO:0048675)2.17016987
120renal system development (GO:0072001)2.16823211
121somite development (GO:0061053)2.16775757
122neural tube closure (GO:0001843)2.16736360
123sympathetic nervous system development (GO:0048485)2.16601176
124negative regulation of microtubule polymerization (GO:0031115)2.16509495
125cerebellum development (GO:0021549)2.16482598
126embryonic skeletal joint morphogenesis (GO:0060272)2.16250425
127protein complex disassembly (GO:0043241)2.16194900
128tube closure (GO:0060606)2.15583476
129lung-associated mesenchyme development (GO:0060484)2.15375337
130DNA strand renaturation (GO:0000733)2.15374967
131regulation of chromatin binding (GO:0035561)2.15211259
132regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.15160411
133regulation of catenin import into nucleus (GO:0035412)2.14920543
134collecting duct development (GO:0072044)2.14873570
135regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13947780
136positive regulation of synapse maturation (GO:0090129)2.13571157
137DNA topological change (GO:0006265)2.09554869
138retinal ganglion cell axon guidance (GO:0031290)2.08754400
139behavioral response to nicotine (GO:0035095)2.07429583
140genetic imprinting (GO:0071514)2.07426897
141positive regulation of neuroblast proliferation (GO:0002052)2.07387750
142cerebral cortex radially oriented cell migration (GO:0021799)2.06948977
143regulation of axon extension involved in axon guidance (GO:0048841)2.05984837
144apical protein localization (GO:0045176)2.05965801
145generation of neurons (GO:0048699)2.05562340
146dorsal/ventral axis specification (GO:0009950)2.04390025
147regulation of axon guidance (GO:1902667)2.04009429
148cellular protein complex disassembly (GO:0043624)2.03874447
149positive regulation of mesonephros development (GO:0061213)2.02382670
150macromolecular complex disassembly (GO:0032984)1.99589974
151embryonic retina morphogenesis in camera-type eye (GO:0060059)1.99360783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.59439594
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.23791098
3EZH2_22144423_ChIP-Seq_EOC_Human3.04700841
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.94885323
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.88556765
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.60951158
7* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.59439613
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48625748
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.17188166
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16903131
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15543320
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.10898178
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.10239247
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06231077
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98561389
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97293101
17* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.97261924
18SOX2_18555785_ChIP-Seq_MESCs_Mouse1.91137073
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83619407
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83355604
21* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.81799121
22* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77019558
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76020987
24* RING1B_27294783_Chip-Seq_NPCs_Mouse1.75802596
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73898956
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.72192511
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69103682
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69103682
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69103682
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.63926411
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62857240
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62063776
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62063776
34* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60546116
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60500928
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59149964
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59063604
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58134207
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56348675
40* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54279555
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54087216
42* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54061297
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53959373
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52989878
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51392768
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50427851
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.49916886
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.47594117
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.47122012
50CTCF_27219007_Chip-Seq_Bcells_Human1.47121491
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46714419
52KDM2B_26808549_Chip-Seq_K562_Human1.45362634
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44770505
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.42377905
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.42022634
56* MYC_22102868_ChIP-Seq_BL_Human1.40452509
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.39958742
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37747209
59* NANOG_21062744_ChIP-ChIP_HESCs_Human1.36409168
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.36127327
61XRN2_22483619_ChIP-Seq_HELA_Human1.35324327
62CIITA_25753668_ChIP-Seq_RAJI_Human1.33331484
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.31999722
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31184982
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30983893
66* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30406245
67KDM2B_26808549_Chip-Seq_DND41_Human1.29392055
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.27632297
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27544640
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.26864761
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25947904
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24347384
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23581234
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22549610
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21173855
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20015135
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19643612
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19160252
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18717009
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18293446
81REST_21632747_ChIP-Seq_MESCs_Mouse1.17837325
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17612289
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17272578
84* FOXP1_21924763_ChIP-Seq_HESCs_Human1.17235313
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16392120
86P68_20966046_ChIP-Seq_HELA_Human1.14999273
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14552526
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13743174
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13532275
90* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12594111
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12586825
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11519760
93* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11466071
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.10054127
95* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10037230
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.09327935
97* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08660149
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08603785
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08419128
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07386451
101RACK7_27058665_Chip-Seq_MCF-7_Human1.07340138
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06993317
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06985807
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06809460
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06221292
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06088938
107SOX3_22085726_ChIP-Seq_NPCs_Mouse1.05937192
108RNF2_27304074_Chip-Seq_NSC_Mouse1.05265990
109* CREB1_26743006_Chip-Seq_LNCaP_Human1.04924512
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03900803
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03840020
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03726897
113* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02370389
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02283933
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02118608
116LXR_22292898_ChIP-Seq_THP-1_Human1.01677718
117TTF2_22483619_ChIP-Seq_HELA_Human1.01671969
118TP53_22127205_ChIP-Seq_IMR90_Human1.01195517
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00641915
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00200805
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00122862
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99303419
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98745585
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97679675
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.97557648
126YY1_21170310_ChIP-Seq_MESCs_Mouse0.96067571
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95786034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.07552686
2MP0003122_maternal_imprinting2.57917858
3MP0009053_abnormal_anal_canal2.42730076
4MP0003123_paternal_imprinting2.42291017
5MP0000537_abnormal_urethra_morphology2.41255564
6MP0003385_abnormal_body_wall2.40877388
7MP0002653_abnormal_ependyma_morphology2.39698724
8MP0003119_abnormal_digestive_system2.27738032
9MP0000049_abnormal_middle_ear2.17314746
10MP0000778_abnormal_nervous_system2.15753843
11MP0002938_white_spotting2.09694955
12MP0002249_abnormal_larynx_morphology2.09064820
13MP0003121_genomic_imprinting2.04325547
14MP0003942_abnormal_urinary_system1.95749036
15MP0008789_abnormal_olfactory_epithelium1.94122116
16MP0002102_abnormal_ear_morphology1.93094060
17MP0006292_abnormal_olfactory_placode1.81911340
18MP0003315_abnormal_perineum_morphology1.77627910
19MP0003861_abnormal_nervous_system1.69812495
20MP0005394_taste/olfaction_phenotype1.69288943
21MP0005499_abnormal_olfactory_system1.69288943
22MP0003567_abnormal_fetal_cardiomyocyte1.63851965
23MP0003937_abnormal_limbs/digits/tail_de1.61007635
24MP0000428_abnormal_craniofacial_morphol1.59266832
25MP0003755_abnormal_palate_morphology1.58965865
26MP0009250_abnormal_appendicular_skeleto1.57638062
27MP0001293_anophthalmia1.57182964
28MP0000534_abnormal_ureter_morphology1.56791090
29MP0003935_abnormal_craniofacial_develop1.56563838
30MP0003115_abnormal_respiratory_system1.56534364
31MP0005623_abnormal_meninges_morphology1.56414827
32MP0005257_abnormal_intraocular_pressure1.54139920
33MP0003136_yellow_coat_color1.52467033
34MP0003890_abnormal_embryonic-extraembry1.50005323
35MP0002085_abnormal_embryonic_tissue1.45437571
36MP0002116_abnormal_craniofacial_bone1.39394000
37MP0003938_abnormal_ear_development1.38952678
38MP0002932_abnormal_joint_morphology1.38642419
39MP0002751_abnormal_autonomic_nervous1.37798428
40MP0003111_abnormal_nucleus_morphology1.36321639
41MP0001188_hyperpigmentation1.36014816
42MP0002084_abnormal_developmental_patter1.35667783
43MP0009379_abnormal_foot_pigmentation1.35475490
44MP0000631_abnormal_neuroendocrine_gland1.34543938
45MP0004197_abnormal_fetal_growth/weight/1.33532120
46MP0002233_abnormal_nose_morphology1.33317854
47MP0002282_abnormal_trachea_morphology1.32322315
48MP0001346_abnormal_lacrimal_gland1.32140284
49MP0004133_heterotaxia1.31831846
50MP0004233_abnormal_muscle_weight1.31811708
51MP0002697_abnormal_eye_size1.28561846
52MP0005248_abnormal_Harderian_gland1.28118670
53MP0002089_abnormal_postnatal_growth/wei1.21925668
54MP0000566_synostosis1.20816015
55MP0003137_abnormal_impulse_conducting1.20689031
56MP0003283_abnormal_digestive_organ1.19892441
57MP0005187_abnormal_penis_morphology1.16981284
58MP0002081_perinatal_lethality1.16459755
59MP0005646_abnormal_pituitary_gland1.15899562
60MP0001286_abnormal_eye_development1.15731683
61MP0001672_abnormal_embryogenesis/_devel1.14942383
62MP0005380_embryogenesis_phenotype1.14942383
63MP0002152_abnormal_brain_morphology1.14383414
64MP0002092_abnormal_eye_morphology1.13638473
65MP0002114_abnormal_axial_skeleton1.13577620
66MP0005423_abnormal_somatic_nervous1.13101541
67MP0001529_abnormal_vocalization1.12108632
68MP0008932_abnormal_embryonic_tissue1.11243859
69MP0002184_abnormal_innervation1.10586685
70MP0009672_abnormal_birth_weight1.10273701
71MP0000955_abnormal_spinal_cord1.09801419
72MP0001697_abnormal_embryo_size1.09661762
73MP0005377_hearing/vestibular/ear_phenot1.09046000
74MP0003878_abnormal_ear_physiology1.09046000
75MP0003635_abnormal_synaptic_transmissio1.08179931
76MP0003787_abnormal_imprinting1.06838161
77MP0002234_abnormal_pharynx_morphology1.06173808
78MP0004858_abnormal_nervous_system1.05550656
79MP0003077_abnormal_cell_cycle1.04279090
80MP0002557_abnormal_social/conspecific_i1.03654982
81MP0005076_abnormal_cell_differentiation1.03644250
82MP0000516_abnormal_urinary_system1.02654763
83MP0005367_renal/urinary_system_phenotyp1.02654763
84MP0002111_abnormal_tail_morphology1.01019875
85MP0004859_abnormal_synaptic_plasticity1.00607868
86MP0004957_abnormal_blastocyst_morpholog1.00275227
87MP0009703_decreased_birth_body1.00002639
88MP0002088_abnormal_embryonic_growth/wei0.99106190
89MP0010094_abnormal_chromosome_stability0.99060249
90MP0002822_catalepsy0.98686518
91MP0003984_embryonic_growth_retardation0.98157757
92MP0000751_myopathy0.98148026
93MP0001730_embryonic_growth_arrest0.97970616
94MP0002063_abnormal_learning/memory/cond0.97435559
95MP0000432_abnormal_head_morphology0.96617848
96MP0006072_abnormal_retinal_apoptosis0.95352711
97MP0000350_abnormal_cell_proliferation0.94345898
98MP0006276_abnormal_autonomic_nervous0.94284965
99MP0002736_abnormal_nociception_after0.93432560
100MP0002127_abnormal_cardiovascular_syste0.92496035
101MP0008995_early_reproductive_senescence0.91489733
102MP0000678_abnormal_parathyroid_gland0.90973958
103MP0003880_abnormal_central_pattern0.90018085
104MP0000762_abnormal_tongue_morphology0.89987577
105MP0002882_abnormal_neuron_morphology0.89978157
106MP0008058_abnormal_DNA_repair0.89524460
107MP0008007_abnormal_cellular_replicative0.89238690
108MP0004270_analgesia0.88252660
109MP0001485_abnormal_pinna_reflex0.87116103
110MP0002734_abnormal_mechanical_nocicepti0.86715991
111MP0000026_abnormal_inner_ear0.86497956
112MP0000462_abnormal_digestive_system0.86265658
113MP0001968_abnormal_touch/_nociception0.86174723
114MP0004885_abnormal_endolymph0.85670293
115MP0002160_abnormal_reproductive_system0.85168489
116MP0001849_ear_inflammation0.84667719
117MP0002080_prenatal_lethality0.84577774
118MP0002752_abnormal_somatic_nervous0.84249004
119MP0005391_vision/eye_phenotype0.84152960
120MP0000579_abnormal_nail_morphology0.83896410
121MP0001340_abnormal_eyelid_morphology0.83785211
122MP0003941_abnormal_skin_development0.83723845
123MP0008877_abnormal_DNA_methylation0.83648033
124MP0001299_abnormal_eye_distance/0.83474556
125MP0002177_abnormal_outer_ear0.82273469
126MP0005409_darkened_coat_color0.82106243
127MP0004145_abnormal_muscle_electrophysio0.81584724
128MP0003705_abnormal_hypodermis_morpholog0.81337095
129MP0001502_abnormal_circadian_rhythm0.81096229
130MP0002572_abnormal_emotion/affect_behav0.79305419
131MP0009384_cardiac_valve_regurgitation0.78883970
132MP0003693_abnormal_embryo_hatching0.76640256

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)3.97464791
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68792820
3Short 4th metacarpal (HP:0010044)3.68792820
4Abnormality of the 4th metacarpal (HP:0010012)3.12014680
5Hyperacusis (HP:0010780)3.07053705
6Turricephaly (HP:0000262)3.02310612
7Hepatoblastoma (HP:0002884)2.85514890
8Overriding aorta (HP:0002623)2.60945029
9Elfin facies (HP:0004428)2.60838736
10Abnormality of the diencephalon (HP:0010662)2.57181996
11Renovascular hypertension (HP:0100817)2.56690210
12Insomnia (HP:0100785)2.53273316
13Septo-optic dysplasia (HP:0100842)2.52789073
14Shallow orbits (HP:0000586)2.51627172
15Shawl scrotum (HP:0000049)2.48801884
16Midline defect of the nose (HP:0004122)2.48634870
17Ependymoma (HP:0002888)2.46875756
18High anterior hairline (HP:0009890)2.45627019
19Partial duplication of thumb phalanx (HP:0009944)2.44026013
20Abnormality of the aortic arch (HP:0012303)2.43009794
21Partial duplication of the phalanx of hand (HP:0009999)2.40695715
22Abnormality of the astrocytes (HP:0100707)2.40261049
23Astrocytoma (HP:0009592)2.40261049
24Vitreoretinal degeneration (HP:0000655)2.36394642
25Increased nuchal translucency (HP:0010880)2.31256520
26Broad distal phalanx of finger (HP:0009836)2.28634315
27Aplasia/Hypoplasia of the patella (HP:0006498)2.21648412
28Flat cornea (HP:0007720)2.21633445
29Sacral dimple (HP:0000960)2.20551322
30Medulloblastoma (HP:0002885)2.14804558
31Patellar aplasia (HP:0006443)2.13456414
32Facial hemangioma (HP:0000329)2.07454893
33Abnormal number of incisors (HP:0011064)2.06704973
34Abnormality of the labia minora (HP:0012880)2.05584477
35Morphological abnormality of the middle ear (HP:0008609)2.04371927
36Concave nail (HP:0001598)2.04230818
37Supernumerary ribs (HP:0005815)2.03974898
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.01878725
39Nephroblastoma (Wilms tumor) (HP:0002667)1.99961625
40Rib fusion (HP:0000902)1.99721448
41Ulnar bowing (HP:0003031)1.96997473
42Arnold-Chiari malformation (HP:0002308)1.96329409
43Broad alveolar ridges (HP:0000187)1.94453116
44Embryonal renal neoplasm (HP:0011794)1.94444570
45Pointed chin (HP:0000307)1.94008293
46Spina bifida occulta (HP:0003298)1.93462864
47Germ cell neoplasia (HP:0100728)1.91103549
48Supernumerary bones of the axial skeleton (HP:0009144)1.89958005
49Patellar dislocation (HP:0002999)1.89129188
50Broad phalanges of the hand (HP:0009768)1.87393548
51Anophthalmia (HP:0000528)1.87378357
52Glioma (HP:0009733)1.87325207
53Megalencephaly (HP:0001355)1.87324495
54Coronal craniosynostosis (HP:0004440)1.86811205
55Renal dysplasia (HP:0000110)1.86152417
56Atresia of the external auditory canal (HP:0000413)1.85958762
57Bilateral microphthalmos (HP:0007633)1.85857894
58Lymphangioma (HP:0100764)1.85329778
59Neoplasm of striated muscle (HP:0009728)1.85148739
60Cutaneous finger syndactyly (HP:0010554)1.84517404
61Bladder diverticulum (HP:0000015)1.83897934
62Megalocornea (HP:0000485)1.83508001
63Asymmetry of the thorax (HP:0001555)1.82714105
64Overgrowth (HP:0001548)1.82330635
65Enlarged penis (HP:0000040)1.82250683
66Aplasia involving bones of the extremities (HP:0009825)1.80211674
67Aplasia involving bones of the upper limbs (HP:0009823)1.80211674
68Aplasia of the phalanges of the hand (HP:0009802)1.80211674
69Abnormality of the metopic suture (HP:0005556)1.79843045
70Bifid tongue (HP:0010297)1.78067878
71Reticulocytopenia (HP:0001896)1.77990393
72Preaxial foot polydactyly (HP:0001841)1.77705706
73Large earlobe (HP:0009748)1.77675108
74Colon cancer (HP:0003003)1.77468871
75Abnormality of the phalanges of the hallux (HP:0010057)1.77375718
76Broad finger (HP:0001500)1.76597048
77Hamartoma (HP:0010566)1.76276155
78Thin ribs (HP:0000883)1.75009290
79Abnormality of cells of the erythroid lineage (HP:0012130)1.74772491
80Hyperthyroidism (HP:0000836)1.71771947
81Duplication of thumb phalanx (HP:0009942)1.71579957
82Obstructive sleep apnea (HP:0002870)1.71570076
83Myelomeningocele (HP:0002475)1.70870121
84Supernumerary spleens (HP:0009799)1.70432939
85Abnormality of the lower motor neuron (HP:0002366)1.69652499
86Broad thumb (HP:0011304)1.69639484
87Cutaneous syndactyly (HP:0012725)1.69199295
88Absent epiphyses (HP:0010577)1.69091375
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69091375
90Broad toe (HP:0001837)1.67911212
91Benign neoplasm of the central nervous system (HP:0100835)1.67482565
92Slender long bone (HP:0003100)1.66226218
93Broad palm (HP:0001169)1.64654639
9411 pairs of ribs (HP:0000878)1.64391187
95Selective tooth agenesis (HP:0001592)1.63645238
96Generalized hypotonia (HP:0001290)1.63142473
97Ectopic kidney (HP:0000086)1.62703376
98Truncus arteriosus (HP:0001660)1.61798840
99Deviation of the hallux (HP:0010051)1.61767439
100Vesicoureteral reflux (HP:0000076)1.61703728
101Broad phalanx (HP:0006009)1.61457972
102Long palpebral fissure (HP:0000637)1.61120309
103Amyotrophic lateral sclerosis (HP:0007354)1.60907760
104Neonatal short-limb short stature (HP:0008921)1.60810192
105Diastasis recti (HP:0001540)1.60317654
106Abnormal lung lobation (HP:0002101)1.59795637
107Short 5th finger (HP:0009237)1.59576426
108Vaginal fistula (HP:0004320)1.58935428
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.58553295
110Hallux valgus (HP:0001822)1.57802433
111Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.56752002
112Optic nerve coloboma (HP:0000588)1.56173660
113Broad long bones (HP:0005622)1.56171804
114Neoplasm of the heart (HP:0100544)1.56120466
115Myokymia (HP:0002411)1.56108840
116Broad hallux (HP:0010055)1.56006527
117Angiofibromas (HP:0010615)1.55767443
118Adenoma sebaceum (HP:0009720)1.55767443
119Bowel diverticulosis (HP:0005222)1.55479259
120Choanal stenosis (HP:0000452)1.55253920
121Abnormal ventriculo-arterial connection (HP:0011563)1.54784316
122Transposition of the great arteries (HP:0001669)1.54784316
123Abnormal connection of the cardiac segments (HP:0011545)1.54784316
124Sudden death (HP:0001699)1.54506612
125Renal hypoplasia (HP:0000089)1.54002114
126Skull defect (HP:0001362)1.53452178
127Maternal diabetes (HP:0009800)1.53299379
128Broad forehead (HP:0000337)1.52633529
129Abnormality of abdominal situs (HP:0011620)1.52251968
130Abdominal situs inversus (HP:0003363)1.52251968
131Absent septum pellucidum (HP:0001331)1.52170691
132Deep palmar crease (HP:0006191)1.51800523
133Trigonocephaly (HP:0000243)1.51575103
134Broad metatarsal (HP:0001783)1.51368450
135Congenital diaphragmatic hernia (HP:0000776)1.51311842
136Abnormality of cochlea (HP:0000375)1.51306346
137Preauricular skin tag (HP:0000384)1.51228314
138Disproportionate tall stature (HP:0001519)1.50715108
139Morphological abnormality of the inner ear (HP:0011390)1.50598823
140Fibroma (HP:0010614)1.49986290
141Short philtrum (HP:0000322)1.49633112
142Rectal fistula (HP:0100590)1.49347991
143Rectovaginal fistula (HP:0000143)1.49347991
144Bronchomalacia (HP:0002780)1.49260257
145Preauricular pit (HP:0004467)1.49009709
146Obsessive-compulsive behavior (HP:0000722)1.47907300
147Heterotopia (HP:0002282)1.47821287
148Abnormality of the middle phalanges of the toes (HP:0010183)1.47476891
149Hemivertebrae (HP:0002937)1.47421941
150Abnormality of the incisor (HP:0000676)1.46555957
151Aplasia/Hypoplasia of the brainstem (HP:0007362)1.46167974
152Hypoplasia of the brainstem (HP:0002365)1.46167974
153Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.45576157
154Intestinal fistula (HP:0100819)1.45320759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.29289103
2TLK13.35429090
3MAP3K103.04757946
4EPHB22.86052056
5ICK2.70315316
6LATS22.64617816
7MKNK22.50574466
8MKNK12.29086573
9SIK12.15862607
10DYRK22.14878662
11VRK22.13112730
12SMG11.98729351
13CDK121.98476488
14FGFR21.96816978
15UHMK11.87230734
16TRIB31.76181145
17PKN21.75691467
18CDC71.75150420
19SRPK11.73208394
20TYRO31.59582396
21TNIK1.58811491
22WNK41.48522396
23NTRK11.47905969
24PHKG11.46452639
25PHKG21.46452639
26LATS11.45189037
27KSR11.41418397
28MAPK131.39584151
29CAMK1G1.38596591
30CASK1.34009821
31BRD41.32780189
32LIMK11.31721731
33PDGFRA1.30900093
34NTRK21.28961988
35ILK1.22243646
36CAMK1D1.21558884
37ERBB31.20710291
38PRPF4B1.15072515
39CDK71.14399733
40TAOK11.13095321
41DDR21.11394536
42EPHA41.09135967
43PTK61.07084185
44MTOR1.04901965
45PRKD30.99624599
46MINK10.95081881
47CHEK20.94268326
48TAF10.93873848
49CDC42BPA0.93734584
50FGFR40.91753442
51MAP3K40.91329076
52ERBB20.91065395
53PLK40.90338911
54EEF2K0.88814153
55NEK20.88236534
56PNCK0.87682585
57PASK0.87147847
58SIK20.86744963
59RPS6KB20.84820890
60PLK10.83050043
61PAK60.82896186
62DYRK30.82518734
63ALK0.77626568
64MARK20.75712784
65AURKA0.75466149
66DYRK1A0.75434936
67CDK20.74746220
68PRKCI0.74526295
69TTK0.73499513
70BRAF0.72623215
71DMPK0.72468195
72CSNK1A1L0.72313092
73SGK2230.71949921
74SGK4940.71949921
75PAK20.69639156
76DAPK30.69501810
77CHEK10.68513034
78CDK190.67492996
79CSNK1E0.66557689
80CSNK1G30.65604616
81HIPK20.65487050
82RPS6KL10.64553454
83RPS6KC10.64553454
84DYRK1B0.63720729
85CDK140.63312100
86CDK11A0.63129307
87NEK10.62942274
88PRKCG0.62206759
89CDK10.61849412
90MUSK0.61586945
91CDK180.61459981
92CDK150.61109626
93RPS6KA20.60801874
94PRKD20.60064581
95PLK30.59935488
96TGFBR10.58911148
97MAP3K90.58897899
98PTK20.58762236
99NTRK30.58682633
100BUB10.58335638
101CLK10.57635079
102AKT30.56572069
103MAP2K70.56285931
104MAPK150.56034969
105MAPK90.55988481
106BRSK10.55824461
107FGFR10.55620670
108CSNK1G20.54192634
109RPS6KA60.54154567
110WNK30.53940245
111WEE10.52920253
112ATR0.52541070
113CDK40.52193837
114ATM0.52139973
115PKN10.51778396
116CSNK1D0.51528383
117AKT10.51158031
118CSNK1G10.50539884
119MAP2K40.49931954
120AKT20.48920099
121CDK80.48782055
122PRKDC0.47619747
123GSK3B0.47411356
124RPS6KA10.47121542
125MAPK80.46711094
126DAPK20.46031165
127ROCK20.45985036
128MAP2K20.45469041
129STK160.43450226
130RIPK10.43102487
131PRKCZ0.42963034
132MAPK140.41832943

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.02929663
2Hedgehog signaling pathway_Homo sapiens_hsa043402.68514648
3Spliceosome_Homo sapiens_hsa030402.54338443
4mRNA surveillance pathway_Homo sapiens_hsa030152.50988016
5Axon guidance_Homo sapiens_hsa043602.32914575
6Mismatch repair_Homo sapiens_hsa034302.24078683
7Hippo signaling pathway_Homo sapiens_hsa043902.19165340
8DNA replication_Homo sapiens_hsa030302.17218860
9Sulfur relay system_Homo sapiens_hsa041222.07295928
10Steroid biosynthesis_Homo sapiens_hsa001002.02879859
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95022842
12RNA transport_Homo sapiens_hsa030131.84899182
13Wnt signaling pathway_Homo sapiens_hsa043101.77348907
14Ribosome_Homo sapiens_hsa030101.75315129
15Cell cycle_Homo sapiens_hsa041101.75126605
16Endometrial cancer_Homo sapiens_hsa052131.69852883
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66405063
18Nucleotide excision repair_Homo sapiens_hsa034201.64171603
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63605285
20Base excision repair_Homo sapiens_hsa034101.63202101
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60485539
22Notch signaling pathway_Homo sapiens_hsa043301.59294470
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54270446
24Oocyte meiosis_Homo sapiens_hsa041141.52748427
25Melanogenesis_Homo sapiens_hsa049161.50550348
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49296277
27Colorectal cancer_Homo sapiens_hsa052101.46198510
28MicroRNAs in cancer_Homo sapiens_hsa052061.41990848
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33462759
30RNA polymerase_Homo sapiens_hsa030201.30715071
31Vitamin B6 metabolism_Homo sapiens_hsa007501.26059328
32Gap junction_Homo sapiens_hsa045401.25588547
33Tight junction_Homo sapiens_hsa045301.25261697
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.24574421
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23349206
36TGF-beta signaling pathway_Homo sapiens_hsa043501.18242551
37Basal transcription factors_Homo sapiens_hsa030221.17535653
38Lysine degradation_Homo sapiens_hsa003101.16497854
39Glioma_Homo sapiens_hsa052141.16071855
40Homologous recombination_Homo sapiens_hsa034401.15832852
41Fanconi anemia pathway_Homo sapiens_hsa034601.13753568
42Bladder cancer_Homo sapiens_hsa052191.13673175
43Adherens junction_Homo sapiens_hsa045201.12304741
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11299817
45Renal cell carcinoma_Homo sapiens_hsa052111.10134949
46Chronic myeloid leukemia_Homo sapiens_hsa052201.07964914
47Non-small cell lung cancer_Homo sapiens_hsa052231.07762273
48ErbB signaling pathway_Homo sapiens_hsa040121.07233553
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07096196
50Thyroid cancer_Homo sapiens_hsa052161.06700928
51Biosynthesis of amino acids_Homo sapiens_hsa012301.03852042
52mTOR signaling pathway_Homo sapiens_hsa041501.02275694
53Dilated cardiomyopathy_Homo sapiens_hsa054141.02095261
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01086241
55Cardiac muscle contraction_Homo sapiens_hsa042601.00706952
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.99928241
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99226555
58Viral myocarditis_Homo sapiens_hsa054160.96444064
59One carbon pool by folate_Homo sapiens_hsa006700.96176121
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.96166743
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91877284
62Pathways in cancer_Homo sapiens_hsa052000.91810341
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91531850
64Melanoma_Homo sapiens_hsa052180.91480046
65Estrogen signaling pathway_Homo sapiens_hsa049150.89542846
66Dopaminergic synapse_Homo sapiens_hsa047280.89224088
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89180967
68RNA degradation_Homo sapiens_hsa030180.88048211
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85570241
70HTLV-I infection_Homo sapiens_hsa051660.84486372
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84114944
72Proteoglycans in cancer_Homo sapiens_hsa052050.84031341
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83358410
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81716841
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.81061483
76Prostate cancer_Homo sapiens_hsa052150.81027590
77VEGF signaling pathway_Homo sapiens_hsa043700.79902299
78Selenocompound metabolism_Homo sapiens_hsa004500.79689532
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79535896
80Alcoholism_Homo sapiens_hsa050340.79341261
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78609618
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74362399
83Insulin signaling pathway_Homo sapiens_hsa049100.72786894
84Focal adhesion_Homo sapiens_hsa045100.72757145
85Phototransduction_Homo sapiens_hsa047440.71114504
86Long-term potentiation_Homo sapiens_hsa047200.70018019
87Small cell lung cancer_Homo sapiens_hsa052220.69302671
88Long-term depression_Homo sapiens_hsa047300.68577179
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68426896
90AMPK signaling pathway_Homo sapiens_hsa041520.67969347
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66797314
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65975284
93Cholinergic synapse_Homo sapiens_hsa047250.65701814
94Insulin secretion_Homo sapiens_hsa049110.65698612
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.65318844
96Rap1 signaling pathway_Homo sapiens_hsa040150.65207645
97Pyruvate metabolism_Homo sapiens_hsa006200.63419831
98Oxytocin signaling pathway_Homo sapiens_hsa049210.62399533
99Circadian entrainment_Homo sapiens_hsa047130.61950763
100GnRH signaling pathway_Homo sapiens_hsa049120.60631339
101Cocaine addiction_Homo sapiens_hsa050300.60338316
102Glutamatergic synapse_Homo sapiens_hsa047240.59505243
103Thyroid hormone synthesis_Homo sapiens_hsa049180.58887172
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57468426
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56829654
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56151793
107GABAergic synapse_Homo sapiens_hsa047270.55733827
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54699065
109ECM-receptor interaction_Homo sapiens_hsa045120.54640854
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53841107
111Olfactory transduction_Homo sapiens_hsa047400.53327899
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52085444
113Pyrimidine metabolism_Homo sapiens_hsa002400.51149136
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.51006045
115Choline metabolism in cancer_Homo sapiens_hsa052310.50093775
116Nicotine addiction_Homo sapiens_hsa050330.49930882
117Prion diseases_Homo sapiens_hsa050200.49455078
118Glucagon signaling pathway_Homo sapiens_hsa049220.49092917
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48274554
120MAPK signaling pathway_Homo sapiens_hsa040100.48100985
121Ras signaling pathway_Homo sapiens_hsa040140.46461224
122Amphetamine addiction_Homo sapiens_hsa050310.46326479
123Fatty acid metabolism_Homo sapiens_hsa012120.46257236
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46041718
125N-Glycan biosynthesis_Homo sapiens_hsa005100.45891206
126Huntingtons disease_Homo sapiens_hsa050160.45582065
127Dorso-ventral axis formation_Homo sapiens_hsa043200.45448588
128Morphine addiction_Homo sapiens_hsa050320.43776810
129Acute myeloid leukemia_Homo sapiens_hsa052210.43274332

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