SOX13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.74716354
2regulation of hippo signaling (GO:0035330)4.07415686
3regulation of gene silencing by miRNA (GO:0060964)4.06090040
4regulation of gene silencing by RNA (GO:0060966)4.06090040
5regulation of posttranscriptional gene silencing (GO:0060147)4.06090040
6anterior/posterior axis specification, embryo (GO:0008595)3.83258898
7establishment of apical/basal cell polarity (GO:0035089)3.79394467
8pre-miRNA processing (GO:0031054)3.67554979
9polarized epithelial cell differentiation (GO:0030859)3.60884813
10positive regulation of SMAD protein import into nucleus (GO:0060391)3.55083434
11heterochromatin organization (GO:0070828)3.54114201
12embryonic foregut morphogenesis (GO:0048617)3.51432933
13notochord development (GO:0030903)3.47776868
14regulation of SMAD protein import into nucleus (GO:0060390)3.32464944
15semaphorin-plexin signaling pathway (GO:0071526)3.30701515
16hippo signaling (GO:0035329)3.29696485
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28744461
18L-alpha-amino acid transmembrane transport (GO:1902475)3.25290617
19DNA unwinding involved in DNA replication (GO:0006268)3.20627133
20renal system development (GO:0072001)3.18631383
21epithelial cell differentiation involved in prostate gland development (GO:0060742)3.15803032
22intestinal epithelial cell development (GO:0060576)3.12106365
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09532386
24bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04381136
25establishment or maintenance of monopolar cell polarity (GO:0061339)3.03354957
26establishment of monopolar cell polarity (GO:0061162)3.03354957
27trophectodermal cell differentiation (GO:0001829)3.03096405
28embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02826125
29endothelial tube morphogenesis (GO:0061154)3.02044729
30morphogenesis of an endothelium (GO:0003159)3.02044729
31lateral sprouting from an epithelium (GO:0060601)3.01699187
32regulation of cardioblast differentiation (GO:0051890)3.01669777
33epithelial cell-cell adhesion (GO:0090136)3.00912933
34vitamin transmembrane transport (GO:0035461)2.98718706
35lung epithelium development (GO:0060428)2.95602088
36ear development (GO:0043583)2.95088318
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94820574
38glomerular basement membrane development (GO:0032836)2.92454915
39biotin metabolic process (GO:0006768)2.92431661
40neural tube development (GO:0021915)2.89937372
41cell surface receptor signaling pathway involved in heart development (GO:0061311)2.86525283
42lung-associated mesenchyme development (GO:0060484)2.83816928
43glomerular epithelial cell development (GO:0072310)2.82785840
44endothelial cell chemotaxis (GO:0035767)2.82705118
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81728992
46negative regulation of translation, ncRNA-mediated (GO:0040033)2.81728992
47regulation of translation, ncRNA-mediated (GO:0045974)2.81728992
48desmosome organization (GO:0002934)2.79954485
49apoptotic process involved in morphogenesis (GO:0060561)2.79452623
50positive regulation of catenin import into nucleus (GO:0035413)2.78666639
51renal filtration (GO:0097205)2.77693543
52apical protein localization (GO:0045176)2.75252374
53ectodermal placode formation (GO:0060788)2.75049794
54adherens junction assembly (GO:0034333)2.73466425
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73314566
56regulation of acrosome reaction (GO:0060046)2.73014683
57endocardial cushion morphogenesis (GO:0003203)2.70178286
58negative regulation of cell fate commitment (GO:0010454)2.69399476
59negative regulation of cell fate specification (GO:0009996)2.67921168
60oocyte development (GO:0048599)2.66318885
61gap junction assembly (GO:0016264)2.66305230
62non-canonical Wnt signaling pathway (GO:0035567)2.62098448
63cell migration involved in sprouting angiogenesis (GO:0002042)2.61856191
64regulation of bile acid biosynthetic process (GO:0070857)2.61664749
65negative regulation of mRNA processing (GO:0050686)2.60866244
66establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58381312
67atrioventricular valve morphogenesis (GO:0003181)2.56580116
68cell-cell junction maintenance (GO:0045217)2.55738794
69branching involved in salivary gland morphogenesis (GO:0060445)2.55193286
70hemidesmosome assembly (GO:0031581)2.54992596
71regulation of sister chromatid cohesion (GO:0007063)2.53773078
72vasculogenesis (GO:0001570)2.53075364
73regulation of translational fidelity (GO:0006450)2.53005286
74formation of translation preinitiation complex (GO:0001731)2.52347522
75intracellular estrogen receptor signaling pathway (GO:0030520)2.51666953
76positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51227602
77regulation of establishment of planar polarity (GO:0090175)2.50806696
78endothelial cell morphogenesis (GO:0001886)2.50097421
79regulation of endothelial cell differentiation (GO:0045601)2.49879843
80cardiac right ventricle morphogenesis (GO:0003215)2.49493720
81surfactant homeostasis (GO:0043129)2.49059605
82heart trabecula formation (GO:0060347)2.48295590
83ectoderm development (GO:0007398)2.48019116
84focal adhesion assembly (GO:0048041)2.47261386
85cell-substrate adherens junction assembly (GO:0007045)2.47261386
86labyrinthine layer development (GO:0060711)2.47081210
87coronary vasculature morphogenesis (GO:0060977)2.46330324
88lymph vessel development (GO:0001945)2.45682706
89nuclear pore organization (GO:0006999)2.44774336
90organ formation (GO:0048645)2.44742558
91respiratory tube development (GO:0030323)2.44405023
92regulation of gene silencing (GO:0060968)2.44103612
93dorsal/ventral axis specification (GO:0009950)2.43989630
94protein localization to kinetochore (GO:0034501)2.43534638
95blood vessel endothelial cell migration (GO:0043534)2.43476676
96regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.42425055
97organ growth (GO:0035265)2.41984559
98establishment or maintenance of apical/basal cell polarity (GO:0035088)2.41771770
99establishment or maintenance of bipolar cell polarity (GO:0061245)2.41771770
100cell-substrate junction assembly (GO:0007044)2.41704344
101lymphangiogenesis (GO:0001946)2.41568671
102lysine catabolic process (GO:0006554)2.41197147
103lysine metabolic process (GO:0006553)2.41197147
104nodal signaling pathway (GO:0038092)2.40760679
105venous blood vessel morphogenesis (GO:0048845)2.39331417
106glomerular filtration (GO:0003094)2.38927585
107regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38856570
108maternal placenta development (GO:0001893)2.38823714
109vascular endothelial growth factor signaling pathway (GO:0038084)2.38739279
110tight junction assembly (GO:0070830)2.37970736
111collecting duct development (GO:0072044)2.37815885
112gastrulation with mouth forming second (GO:0001702)2.37042588
113Notch signaling involved in heart development (GO:0061314)2.36809686
114cell migration involved in gastrulation (GO:0042074)2.36542635
115serine family amino acid catabolic process (GO:0009071)2.36192295
116endothelial cell differentiation (GO:0045446)2.33307075
117cell junction maintenance (GO:0034331)2.32437289
118glomerular visceral epithelial cell development (GO:0072015)2.32094094
119DNA replication-dependent nucleosome organization (GO:0034723)2.29554376
120DNA replication-dependent nucleosome assembly (GO:0006335)2.29554376
121L-serine metabolic process (GO:0006563)2.28993052
122basement membrane organization (GO:0071711)2.28624720
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28613995
124convergent extension (GO:0060026)2.28481499
125aorta morphogenesis (GO:0035909)2.28426905
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28212468
127negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.27971447
128anterior/posterior axis specification (GO:0009948)2.27564069
129negative regulation of RNA splicing (GO:0033119)2.27431848
130ventricular trabecula myocardium morphogenesis (GO:0003222)2.27318031
131proximal/distal pattern formation (GO:0009954)2.27299301
132prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.27167930
133mesenchyme morphogenesis (GO:0072132)2.27161646
134regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.27021432
135regulation of catenin import into nucleus (GO:0035412)2.26671392
136establishment of planar polarity (GO:0001736)2.26407517
137establishment of tissue polarity (GO:0007164)2.26407517
138white fat cell differentiation (GO:0050872)2.26293579
139epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.25986929
140response to food (GO:0032094)2.25929657
141regulation of cell fate specification (GO:0042659)2.24723503
142mesenchymal to epithelial transition (GO:0060231)2.24670711
143phosphate ion homeostasis (GO:0055062)2.23964489
144trivalent inorganic anion homeostasis (GO:0072506)2.23964489
145labyrinthine layer blood vessel development (GO:0060716)2.23956937
146embryonic axis specification (GO:0000578)2.23131596
147asymmetric protein localization (GO:0008105)2.21182257
148body morphogenesis (GO:0010171)2.20788061
149multicellular organismal water homeostasis (GO:0050891)2.20505647
150insulin-like growth factor receptor signaling pathway (GO:0048009)2.17768719
151positive regulation of hormone metabolic process (GO:0032352)2.17056391
152embryonic body morphogenesis (GO:0010172)2.16644344
153mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.16369686
154positive regulation of cell cycle G2/M phase transition (GO:1902751)2.15819596
155positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.15819596
156regulation of establishment or maintenance of cell polarity (GO:0032878)2.15528961
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15032135
158neural tube closure (GO:0001843)2.13359578
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.12918780
160cellular modified amino acid catabolic process (GO:0042219)2.11411782
161tube closure (GO:0060606)2.10369224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.19263458
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.78543045
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.30771156
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.30771156
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.30771156
6TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.25684969
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.25012289
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.88529296
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66236041
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58027968
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57296188
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37051250
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34214682
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.33904799
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28836560
16* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26600402
17ZNF263_19887448_ChIP-Seq_K562_Human2.23133692
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21515254
19CLOCK_20551151_ChIP-Seq_293T_Human2.21481013
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.19605596
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15215951
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.09512761
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09322651
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.03715399
25AR_21909140_ChIP-Seq_LNCAP_Human1.98957921
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.95787281
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95702539
28* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.94344032
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92071585
30* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84636598
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.84147214
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81629032
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76325304
34* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75989219
35* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75859344
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75729308
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75024038
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73803130
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73115549
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70529563
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70126915
42MYC_22102868_ChIP-Seq_BL_Human1.69494727
43CTCF_27219007_Chip-Seq_Bcells_Human1.68200790
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.67245210
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67239997
46* ESR2_21235772_ChIP-Seq_MCF-7_Human1.66839739
47DROSHA_22980978_ChIP-Seq_HELA_Human1.65196624
48* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63282442
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62038809
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62003289
51* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60769405
52EZH2_22144423_ChIP-Seq_EOC_Human1.59994647
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59046637
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57717886
55AHR_22903824_ChIP-Seq_MCF-7_Human1.52723577
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50358414
57SMC4_20622854_ChIP-Seq_HELA_Human1.50272566
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48509414
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48064828
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47060541
61NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45045780
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44537241
63ATF3_27146783_Chip-Seq_COLON_Human1.42578771
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41889942
65* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41657426
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.39360543
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39146443
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37016362
69* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32591683
70* P68_20966046_ChIP-Seq_HELA_Human1.32530949
71KDM2B_26808549_Chip-Seq_DND41_Human1.32029212
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31882784
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31140534
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29260340
75* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28121532
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27599376
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27079221
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.26312641
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.25758403
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25741036
81KLF5_25053715_ChIP-Seq_YYC3_Human1.25644952
82* LXR_22292898_ChIP-Seq_THP-1_Human1.23822803
83* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22155256
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22104767
85* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22055295
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20166639
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.20000150
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19681409
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19489729
90GATA6_25053715_ChIP-Seq_YYC3_Human1.18893864
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.18890434
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18421083
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17547309
94* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17449451
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17213008
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.16964057
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16655249
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15315041
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.15056082
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.14845643
101TCF7_22412390_ChIP-Seq_EML_Mouse1.14720841
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.14119520
103TP63_22573176_ChIP-Seq_HFKS_Human1.13647184
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13264457
105* CREB1_26743006_Chip-Seq_LNCaP_Human1.13192958
106TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13148116
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13029014
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12698941
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12570372
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11149295
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10420785
112* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08701700
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08516883
114* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08040034
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07837595
116* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07380564
117* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06527924
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05544362
119KDM2B_26808549_Chip-Seq_K562_Human1.05079779
120ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05062129
121* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04604643
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03925482
123XRN2_22483619_ChIP-Seq_HELA_Human1.03514861
124* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02052524
125NCOR1_26117541_ChIP-Seq_K562_Human1.01471315
126* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01333197
127VDR_21846776_ChIP-Seq_THP-1_Human1.00600643
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00365965
129TET1_21490601_ChIP-Seq_MESCs_Mouse0.99799748
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99635456
131* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99596251
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.99282965
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98635747
134* EZH2_27294783_Chip-Seq_ESCs_Mouse0.97775856
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95154595
136TP53_22127205_ChIP-Seq_IMR90_Human0.94674275
137* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93888979
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93647607
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93367189
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92954327
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91971236
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.91709838
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91161122
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.90680552
145GATA4_25053715_ChIP-Seq_YYC3_Human0.89469122
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.88479168
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.87619199
148OCT4_19829295_ChIP-Seq_ESCs_Human0.85832355
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.85652969
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85442161
151OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84148715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.60762729
2MP0003705_abnormal_hypodermis_morpholog3.07259109
3MP0000537_abnormal_urethra_morphology3.01557720
4MP0003136_yellow_coat_color2.90601939
5MP0010030_abnormal_orbit_morphology2.58068244
6MP0004272_abnormal_basement_membrane2.54104789
7MP0010368_abnormal_lymphatic_system2.40011212
8MP0003878_abnormal_ear_physiology2.27144726
9MP0005377_hearing/vestibular/ear_phenot2.27144726
10MP0005670_abnormal_white_adipose2.24965216
11MP0002653_abnormal_ependyma_morphology2.24404541
12MP0009053_abnormal_anal_canal2.19882677
13MP0003283_abnormal_digestive_organ2.12713985
14MP0010352_gastrointestinal_tract_polyps2.12052288
15MP0010234_abnormal_vibrissa_follicle2.08286397
16MP0003119_abnormal_digestive_system2.01538882
17MP0001849_ear_inflammation1.91119791
18MP0000579_abnormal_nail_morphology1.89992584
19MP0004264_abnormal_extraembryonic_tissu1.88016004
20MP0009780_abnormal_chondrocyte_physiolo1.84900156
21MP0004084_abnormal_cardiac_muscle1.84500150
22MP0003941_abnormal_skin_development1.82583230
23MP0004957_abnormal_blastocyst_morpholog1.72881138
24MP0001730_embryonic_growth_arrest1.71158723
25MP0003693_abnormal_embryo_hatching1.67922831
26MP0005380_embryogenesis_phenotype1.63827775
27MP0001672_abnormal_embryogenesis/_devel1.63827775
28MP0003718_maternal_effect1.62601846
29MP0005083_abnormal_biliary_tract1.61631413
30MP0003984_embryonic_growth_retardation1.60631178
31MP0003115_abnormal_respiratory_system1.60150861
32MP0009672_abnormal_birth_weight1.59114202
33MP0002085_abnormal_embryonic_tissue1.58591946
34MP0002088_abnormal_embryonic_growth/wei1.58589068
35MP0002084_abnormal_developmental_patter1.56929080
36MP0005076_abnormal_cell_differentiation1.54648657
37MP0005167_abnormal_blood-brain_barrier1.52086670
38MP0004858_abnormal_nervous_system1.51962948
39MP0003566_abnormal_cell_adhesion1.51483341
40MP0002086_abnormal_extraembryonic_tissu1.50876290
41MP0009278_abnormal_bone_marrow1.47313591
42MP0003567_abnormal_fetal_cardiomyocyte1.45547333
43MP0003111_abnormal_nucleus_morphology1.42355069
44MP0004197_abnormal_fetal_growth/weight/1.41149496
45MP0000534_abnormal_ureter_morphology1.39924572
46MP0004782_abnormal_surfactant_physiolog1.38127929
47MP0005365_abnormal_bile_salt1.37447269
48MP0000566_synostosis1.36050759
49MP0002249_abnormal_larynx_morphology1.35575956
50MP0001697_abnormal_embryo_size1.31732486
51MP0001879_abnormal_lymphatic_vessel1.30650785
52MP0000462_abnormal_digestive_system1.27578109
53MP0002938_white_spotting1.27143974
54MP0000003_abnormal_adipose_tissue1.23113084
55MP0002925_abnormal_cardiovascular_devel1.22674751
56MP0005257_abnormal_intraocular_pressure1.20971886
57MP0003935_abnormal_craniofacial_develop1.20071463
58MP0002932_abnormal_joint_morphology1.20055128
59MP0003123_paternal_imprinting1.19301865
60MP0010678_abnormal_skin_adnexa1.18354630
61MP0001293_anophthalmia1.18313394
62MP0010630_abnormal_cardiac_muscle1.17963351
63MP0003077_abnormal_cell_cycle1.15756040
64MP0002282_abnormal_trachea_morphology1.14813838
65MP0000428_abnormal_craniofacial_morphol1.14739601
66MP0002909_abnormal_adrenal_gland1.14681175
67MP0004133_heterotaxia1.14654472
68MP0000350_abnormal_cell_proliferation1.11311427
69MP0006138_congestive_heart_failure1.09899835
70MP0000467_abnormal_esophagus_morphology1.09797287
71MP0003828_pulmonary_edema1.09441348
72MP0004381_abnormal_hair_follicle1.09177211
73MP0005409_darkened_coat_color1.09000463
74MP0002697_abnormal_eye_size1.08526747
75MP0005360_urolithiasis1.07717290
76MP0003890_abnormal_embryonic-extraembry1.07586318
77MP0000516_abnormal_urinary_system1.06832426
78MP0005367_renal/urinary_system_phenotyp1.06832426
79MP0002080_prenatal_lethality1.06254348
80MP0000049_abnormal_middle_ear1.05867163
81MP0004019_abnormal_vitamin_homeostasis1.05844658
82MP0009384_cardiac_valve_regurgitation1.05423006
83MP0003195_calcinosis1.05316503
84MP0005501_abnormal_skin_physiology1.05314773
85MP0003942_abnormal_urinary_system1.04769346
86MP0005248_abnormal_Harderian_gland1.03525018
87MP0000750_abnormal_muscle_regeneration1.03001701
88MP0000678_abnormal_parathyroid_gland1.02866009
89MP0000751_myopathy1.02634204
90MP0005187_abnormal_penis_morphology1.02614617
91MP0005623_abnormal_meninges_morphology1.02345996
92MP0000733_abnormal_muscle_development1.02055593
93MP0002111_abnormal_tail_morphology1.01316989
94MP0005275_abnormal_skin_tensile1.00815310
95MP0000383_abnormal_hair_follicle1.00664138
96MP0000767_abnormal_smooth_muscle0.99066752
97MP0000762_abnormal_tongue_morphology0.97928911
98MP0002092_abnormal_eye_morphology0.97639366
99MP0001958_emphysema0.97483996
100MP0005330_cardiomyopathy0.97429132
101MP0005375_adipose_tissue_phenotype0.96156542
102MP0002098_abnormal_vibrissa_morphology0.95803888
103MP0000266_abnormal_heart_morphology0.95667070
104MP0004043_abnormal_pH_regulation0.95607617
105MP0002116_abnormal_craniofacial_bone0.95029714
106MP0005023_abnormal_wound_healing0.93834388
107MP0002127_abnormal_cardiovascular_syste0.93142895
108MP0003861_abnormal_nervous_system0.92026107
109MP0010329_abnormal_lipoprotein_level0.91732870
110MP0003937_abnormal_limbs/digits/tail_de0.91471973
111MP0002796_impaired_skin_barrier0.91221198
112MP0000377_abnormal_hair_follicle0.91052159
113MP0004185_abnormal_adipocyte_glucose0.90357238
114MP0004233_abnormal_muscle_weight0.90091704
115MP0005085_abnormal_gallbladder_physiolo0.89526906
116MP0002108_abnormal_muscle_morphology0.88971294
117MP0005508_abnormal_skeleton_morphology0.88398938
118MP0008961_abnormal_basal_metabolism0.88341668
119MP0001188_hyperpigmentation0.87448805
120MP0000432_abnormal_head_morphology0.87173449
121MP0008438_abnormal_cutaneous_collagen0.86840231
122MP0009703_decreased_birth_body0.86229888
123MP0003938_abnormal_ear_development0.84340562
124MP0001485_abnormal_pinna_reflex0.84209913
125MP0001286_abnormal_eye_development0.83430981
126MP0001614_abnormal_blood_vessel0.82978268
127MP0005666_abnormal_adipose_tissue0.82174597
128MP0003315_abnormal_perineum_morphology0.82102084
129MP0008932_abnormal_embryonic_tissue0.81845466
130MP0000427_abnormal_hair_cycle0.81757418
131MP0001502_abnormal_circadian_rhythm0.80863605
132MP0004087_abnormal_muscle_fiber0.80766626
133MP0002233_abnormal_nose_morphology0.80273841
134MP0001299_abnormal_eye_distance/0.80137513
135MP0003252_abnormal_bile_duct0.78994755
136MP0001666_abnormal_nutrient_absorption0.78543809
137MP0008875_abnormal_xenobiotic_pharmacok0.78235736
138MP0001346_abnormal_lacrimal_gland0.77947101
139MP0005379_endocrine/exocrine_gland_phen0.76278732
140MP0003755_abnormal_palate_morphology0.72370865
141MP0003936_abnormal_reproductive_system0.68678044
142MP0005395_other_phenotype0.68410328
143MP0000627_abnormal_mammary_gland0.68069007
144MP0000647_abnormal_sebaceous_gland0.67303236
145MP0005171_absent_coat_pigmentation0.66932193

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.17192281
2Rectal prolapse (HP:0002035)2.99510065
3Right ventricular cardiomyopathy (HP:0011663)2.91454513
4Shawl scrotum (HP:0000049)2.85221033
5Esophageal atresia (HP:0002032)2.78759980
6Renal duplication (HP:0000075)2.59853980
7Bilateral microphthalmos (HP:0007633)2.51075072
8Polycythemia (HP:0001901)2.50903962
9Mesangial abnormality (HP:0001966)2.44751669
10Broad metatarsal (HP:0001783)2.43397178
11Genetic anticipation (HP:0003743)2.43293337
12Concave nail (HP:0001598)2.41402697
13Choanal stenosis (HP:0000452)2.38169658
14Increased connective tissue (HP:0009025)2.28804853
15Abnormality of the astrocytes (HP:0100707)2.28173819
16Astrocytoma (HP:0009592)2.28173819
17Shallow orbits (HP:0000586)2.27725110
18Esophageal varix (HP:0002040)2.26757268
19Cerebral aneurysm (HP:0004944)2.26551500
20Ventricular tachycardia (HP:0004756)2.25787526
21Colon cancer (HP:0003003)2.25480669
22Lymphangioma (HP:0100764)2.24987780
23Skull defect (HP:0001362)2.24977392
24Renovascular hypertension (HP:0100817)2.23567064
25Fused cervical vertebrae (HP:0002949)2.23214005
26Lip pit (HP:0100267)2.21201043
27Abnormality of the salivary glands (HP:0010286)2.17947544
28Selective tooth agenesis (HP:0001592)2.16723997
29J-shaped sella turcica (HP:0002680)2.16642542
30Short 4th metacarpal (HP:0010044)2.16102479
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16102479
32Enlarged penis (HP:0000040)2.13971055
33Ankle contracture (HP:0006466)2.10615677
34Aplasia involving bones of the upper limbs (HP:0009823)2.10187032
35Aplasia of the phalanges of the hand (HP:0009802)2.10187032
36Aplasia involving bones of the extremities (HP:0009825)2.10187032
37Gastrointestinal atresia (HP:0002589)2.09721684
38Hyperacusis (HP:0010780)2.07807166
39Amelogenesis imperfecta (HP:0000705)2.06164238
40Dysmetric saccades (HP:0000641)2.05008155
41Tubular atrophy (HP:0000092)2.04409948
42Muscle fiber splitting (HP:0003555)2.04016166
43Pseudobulbar signs (HP:0002200)2.01980130
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00727901
45Abnormality of the dental root (HP:0006486)1.99442927
46Taurodontia (HP:0000679)1.99442927
47Abnormality of permanent molar morphology (HP:0011071)1.99442927
48Abnormality of the nasal septum (HP:0000419)1.99215233
49Biliary tract neoplasm (HP:0100574)1.98319255
50Rib fusion (HP:0000902)1.97790961
51Abnormality of the lacrimal duct (HP:0011481)1.96670461
52Neoplasm of striated muscle (HP:0009728)1.95718717
53Clumsiness (HP:0002312)1.95320832
54Partial duplication of thumb phalanx (HP:0009944)1.95089024
55Turricephaly (HP:0000262)1.95042015
56Decreased circulating renin level (HP:0003351)1.94042583
57Visceral angiomatosis (HP:0100761)1.93683992
58Chronic bronchitis (HP:0004469)1.92704202
59Abnormality of the 4th metacarpal (HP:0010012)1.92674927
60Vertebral fusion (HP:0002948)1.92197210
61Milia (HP:0001056)1.92170465
62Hematochezia (HP:0002573)1.92023234
63Abnormality of the dental pulp (HP:0006479)1.91611802
64Malignant gastrointestinal tract tumors (HP:0006749)1.91520849
65Gastrointestinal carcinoma (HP:0002672)1.91520849
66Abnormal number of incisors (HP:0011064)1.90772902
67Germ cell neoplasia (HP:0100728)1.90538190
68Supernumerary ribs (HP:0005815)1.90200853
69Vertebral clefting (HP:0008428)1.90179615
70Hepatoblastoma (HP:0002884)1.89641734
71Hyperglycinuria (HP:0003108)1.88993160
72Medulloblastoma (HP:0002885)1.87032953
73Flat acetabular roof (HP:0003180)1.86221334
74Protrusio acetabuli (HP:0003179)1.85547690
75Short phalanx of the thumb (HP:0009660)1.85531397
76Neoplasm of the oral cavity (HP:0100649)1.84999682
77Absent eyebrow (HP:0002223)1.83820339
78Spastic diplegia (HP:0001264)1.83421945
79Duplicated collecting system (HP:0000081)1.83334950
80Metaphyseal cupping (HP:0003021)1.83220751
81Abnormality of molar morphology (HP:0011070)1.82576634
82Abnormality of molar (HP:0011077)1.82576634
83Abnormality of the vitreous humor (HP:0004327)1.82410770
84Difficulty running (HP:0009046)1.82336997
85Abnormality of renin-angiotensin system (HP:0000847)1.81699149
86Morphological abnormality of the middle ear (HP:0008609)1.80201996
87Aplasia/hypoplasia of the humerus (HP:0006507)1.79946951
88Glioma (HP:0009733)1.78441897
89Oligodontia (HP:0000677)1.78271362
90Short humerus (HP:0005792)1.77938633
91Missing ribs (HP:0000921)1.77931334
92Wrist flexion contracture (HP:0001239)1.77820789
93Hypoplastic ischia (HP:0003175)1.77468148
94Adactyly (HP:0009776)1.77354937
95Abnormal vertebral ossification (HP:0100569)1.77030257
96High pitched voice (HP:0001620)1.77016567
97Abnormality of the diencephalon (HP:0010662)1.76875390
98Abnormality of the aortic arch (HP:0012303)1.76495974
99Intestinal polyp (HP:0005266)1.75983568
100Broad thumb (HP:0011304)1.75972829
101Hemivertebrae (HP:0002937)1.75944307
102Aneurysm (HP:0002617)1.75938482
103Hemangiomatosis (HP:0007461)1.75839734
104Difficulty climbing stairs (HP:0003551)1.75080210
105Preaxial foot polydactyly (HP:0001841)1.74943290
106Advanced eruption of teeth (HP:0006288)1.73641596
107Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.73614245
108Focal segmental glomerulosclerosis (HP:0000097)1.73474175
109Pendular nystagmus (HP:0012043)1.72688205
110Breast hypoplasia (HP:0003187)1.72532455
111Absent radius (HP:0003974)1.71514236
112Ulnar bowing (HP:0003031)1.71458406
113Gout (HP:0001997)1.70641290
114Urethral obstruction (HP:0000796)1.69453473
115Supernumerary bones of the axial skeleton (HP:0009144)1.68445464
116Broad toe (HP:0001837)1.67559759
117Multiple enchondromatosis (HP:0005701)1.67478222
118Down-sloping shoulders (HP:0200021)1.67350926
119Anophthalmia (HP:0000528)1.67300066
120Bronchomalacia (HP:0002780)1.67220565
121Skin tags (HP:0010609)1.66840878
122Hyperaldosteronism (HP:0000859)1.66602073
123Elfin facies (HP:0004428)1.66403268
124Rhabdomyosarcoma (HP:0002859)1.66196418
125Bicornuate uterus (HP:0000813)1.66043739
126Intestinal polyposis (HP:0200008)1.66035163
127Anal stenosis (HP:0002025)1.63673741
128Absent forearm bone (HP:0003953)1.63227791
129Aplasia involving forearm bones (HP:0009822)1.63227791
130Back pain (HP:0003418)1.63142288
131Abnormality of the renal collecting system (HP:0004742)1.62819995
132Tracheal stenosis (HP:0002777)1.62787364
133Fibroma (HP:0010614)1.62787116
134Impulsivity (HP:0100710)1.62230721
135Malnutrition (HP:0004395)1.61952812
136Hyperkalemia (HP:0002153)1.61893274
137Abnormality of proline metabolism (HP:0010907)1.61839878
138Hydroxyprolinuria (HP:0003080)1.61839878
139Absent toe (HP:0010760)1.61259451
140Depressed nasal tip (HP:0000437)1.60903589
141Overriding aorta (HP:0002623)1.60241808
142Increased nuchal translucency (HP:0010880)1.60017582
143Hyperactive renin-angiotensin system (HP:0000841)1.59948030
144Oligodactyly (HP:0012165)1.59434780
145Stridor (HP:0010307)1.59240457
146Hypoplastic toenails (HP:0001800)1.58109924
147Abnormality of monocarboxylic acid metabolism (HP:0010996)1.58070394
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57786478
149Absent epiphyses (HP:0010577)1.57786478
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.57509013
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57334489
152Abnormality of serine family amino acid metabolism (HP:0010894)1.57182256
153Abnormality of glycine metabolism (HP:0010895)1.57182256
154Hip contracture (HP:0003273)1.57087799
155Pili torti (HP:0003777)1.57038294
156Patellar aplasia (HP:0006443)1.56842729
157Preauricular skin tag (HP:0000384)1.56537378
158Unilateral renal agenesis (HP:0000122)1.56444984
159Coronal craniosynostosis (HP:0004440)1.56397512
160Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55794455
161Renal salt wasting (HP:0000127)1.55790042
162Hypoplastic labia majora (HP:0000059)1.55690880
163Abnormality of abdominal situs (HP:0011620)1.55671480
164Abdominal situs inversus (HP:0003363)1.55671480
165Arnold-Chiari malformation (HP:0002308)1.55552515
166Duplication of thumb phalanx (HP:0009942)1.55220239
167Hypercalciuria (HP:0002150)1.55156502
168Renal dysplasia (HP:0000110)1.54068798
169Hypopigmentation of the fundus (HP:0007894)1.53604160
170Facial cleft (HP:0002006)1.53426583
171Cutaneous finger syndactyly (HP:0010554)1.52411587
172Non-midline cleft lip (HP:0100335)1.51655162
173Natal tooth (HP:0000695)1.50575080
174Pterygium (HP:0001059)1.49498555
175Abnormality of the nasolacrimal system (HP:0000614)1.47854708
176Abnormality of chloride homeostasis (HP:0011422)1.47513200
177Spina bifida occulta (HP:0003298)1.46449449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.61713932
2TIE13.33070635
3EPHA23.24446534
4EPHB22.87768670
5TRIB32.81570599
6LATS12.79814494
7MST1R2.63670264
8MAP3K102.59902578
9SMG12.32740105
10PAK42.29584525
11DDR22.28372310
12RIPK12.03369119
13PKN21.93927011
14PDGFRA1.84526896
15NEK11.84094383
16ICK1.81419265
17LATS21.68619653
18TGFBR21.68106004
19EEF2K1.67302666
20TGFBR11.63248744
21NEK21.58989405
22STK38L1.58923265
23PTK61.55362078
24WNK41.54369865
25ERN11.53953904
26NME11.53292450
27CDC71.50637707
28CAMK1G1.49779444
29TTN1.49687941
30KDR1.46676853
31CDK71.41575222
32TTK1.40420298
33PASK1.38861306
34MTOR1.31041229
35WEE11.28944059
36MAP2K21.23397835
37NTRK11.23108219
38STK101.21984854
39BUB11.21404593
40LMTK21.20161685
41SIK11.11329249
42MET1.11144890
43TYRO31.09876707
44FER1.09390974
45TSSK61.09292159
46STK31.06081002
47RPS6KB21.03769650
48PTK21.03236552
49AKT31.01506887
50RPS6KA21.00530602
51CDK40.96608214
52CDK60.94880057
53MAP3K80.91606218
54ERBB40.91426636
55TNIK0.91279897
56BRD40.91204850
57AKT20.89770582
58FGFR10.89561810
59LRRK20.88144734
60FRK0.87465799
61PRKAA20.86256493
62NEK60.86003956
63TAF10.85239287
64PAK20.85149691
65MAP2K30.82238851
66BCKDK0.82090245
67DMPK0.80653686
68AURKB0.79874445
69CDC42BPA0.79544422
70MAPK150.78492830
71MAP3K30.77436172
72PRKCI0.77305036
73INSRR0.76598542
74MAP3K90.75868806
75ERBB20.73947177
76BMX0.73022146
77PDK40.71325998
78PDK30.71325998
79PLK10.71301831
80MUSK0.71043923
81MYLK0.69451627
82PHKG10.69106457
83CHUK0.68255538
84VRK20.66638552
85DYRK1B0.64775302
86TESK20.64500414
87PRKAA10.63633718
88DYRK30.62864669
89PNCK0.62277830
90FGFR20.62270418
91CHEK10.60286223
92EPHB10.59462215
93FGFR40.59328527
94TAOK10.58894537
95ILK0.58250342
96CAMK1D0.57577291
97ALK0.56372537
98STK40.55102130
99GSK3A0.54227809
100MARK20.53774343
101PDK20.52434927
102PDGFRB0.51700734
103OXSR10.51678043
104MKNK20.49795897
105CDK20.49202011
106MAP3K70.48927791
107CHEK20.48320090
108PRKD20.47340125
109GRK10.46777763
110PRKG20.46692733
111WNK30.46388734
112RPS6KA60.45702525
113MAP3K110.45642337
114MELK0.44566114
115STK390.44506590
116TESK10.44114269
117GSK3B0.43748361
118SCYL20.43162034
119CSNK1E0.42081825
120RPS6KA10.40876153
121STK380.40841996
122CDK10.39471173
123NTRK20.38887052
124MAPKAPK30.38616806
125PRKD30.38610433
126RPS6KL10.38415306
127RPS6KC10.38415306
128CSNK1D0.38225777
129GRK60.37877693
130PAK10.37533347
131PRKD10.36984487
132AURKA0.34956717
133CASK0.34485022
134SIK20.33983435
135FLT30.33906141
136MAPK80.33099140
137ATR0.31092084
138NLK0.30444210
139MAPK100.30393140
140HIPK20.30093590
141AKT10.29655754
142PRKCZ0.29325616
143ATM0.29205478
144PHKG20.29162189

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.63610663
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29754157
3Notch signaling pathway_Homo sapiens_hsa043302.28691035
4Hippo signaling pathway_Homo sapiens_hsa043902.22704110
5Histidine metabolism_Homo sapiens_hsa003402.08315849
6Adherens junction_Homo sapiens_hsa045202.05894822
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.96313459
8Lysine degradation_Homo sapiens_hsa003101.80735600
9Hedgehog signaling pathway_Homo sapiens_hsa043401.80046459
10RNA transport_Homo sapiens_hsa030131.77524826
11Tight junction_Homo sapiens_hsa045301.74822008
12Spliceosome_Homo sapiens_hsa030401.66978879
13Fat digestion and absorption_Homo sapiens_hsa049751.64765834
14ECM-receptor interaction_Homo sapiens_hsa045121.62894573
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60313297
16DNA replication_Homo sapiens_hsa030301.57353355
17Small cell lung cancer_Homo sapiens_hsa052221.56941367
18Bladder cancer_Homo sapiens_hsa052191.56867593
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49264974
20Protein digestion and absorption_Homo sapiens_hsa049741.49070451
21TGF-beta signaling pathway_Homo sapiens_hsa043501.48931265
22Mismatch repair_Homo sapiens_hsa034301.48097412
23ABC transporters_Homo sapiens_hsa020101.42635047
24Biosynthesis of amino acids_Homo sapiens_hsa012301.39282227
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38131088
26Phenylalanine metabolism_Homo sapiens_hsa003601.37940647
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37270630
28Cell cycle_Homo sapiens_hsa041101.36467271
29MicroRNAs in cancer_Homo sapiens_hsa052061.36123028
30Thyroid cancer_Homo sapiens_hsa052161.35979456
31Ovarian steroidogenesis_Homo sapiens_hsa049131.34713291
32Linoleic acid metabolism_Homo sapiens_hsa005911.33781077
33Focal adhesion_Homo sapiens_hsa045101.33764915
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33543007
35mRNA surveillance pathway_Homo sapiens_hsa030151.30986229
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29969818
37Renin-angiotensin system_Homo sapiens_hsa046141.28977973
38Retinol metabolism_Homo sapiens_hsa008301.28382109
39Carbon metabolism_Homo sapiens_hsa012001.27573484
40Caffeine metabolism_Homo sapiens_hsa002321.24024091
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22366595
42Proteoglycans in cancer_Homo sapiens_hsa052051.22205420
43Nitrogen metabolism_Homo sapiens_hsa009101.21753643
44Fatty acid degradation_Homo sapiens_hsa000711.21203238
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20915473
46Dorso-ventral axis formation_Homo sapiens_hsa043201.18675652
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13779499
48Tyrosine metabolism_Homo sapiens_hsa003501.13372308
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13064793
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12197122
51Selenocompound metabolism_Homo sapiens_hsa004501.09142505
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04762300
53Base excision repair_Homo sapiens_hsa034101.04561281
54Chemical carcinogenesis_Homo sapiens_hsa052041.04445135
55Axon guidance_Homo sapiens_hsa043601.04122355
56Arginine biosynthesis_Homo sapiens_hsa002201.03330590
57Vitamin digestion and absorption_Homo sapiens_hsa049771.03134603
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.02429133
59Vitamin B6 metabolism_Homo sapiens_hsa007501.00608465
60Pathways in cancer_Homo sapiens_hsa052000.99010643
61Galactose metabolism_Homo sapiens_hsa000520.98014332
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.97327943
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96936649
64One carbon pool by folate_Homo sapiens_hsa006700.95278019
65Bile secretion_Homo sapiens_hsa049760.95129052
66mTOR signaling pathway_Homo sapiens_hsa041500.94036521
67Arginine and proline metabolism_Homo sapiens_hsa003300.93841304
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93820996
69Wnt signaling pathway_Homo sapiens_hsa043100.91665970
70Sulfur relay system_Homo sapiens_hsa041220.91558836
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90090744
72Mineral absorption_Homo sapiens_hsa049780.89389285
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.88467024
74Chronic myeloid leukemia_Homo sapiens_hsa052200.88163069
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.87734374
76Tryptophan metabolism_Homo sapiens_hsa003800.87084864
77Endometrial cancer_Homo sapiens_hsa052130.86682460
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86298360
79Insulin resistance_Homo sapiens_hsa049310.85066084
80Folate biosynthesis_Homo sapiens_hsa007900.84371769
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.84117103
82Fatty acid metabolism_Homo sapiens_hsa012120.83880143
83PPAR signaling pathway_Homo sapiens_hsa033200.83681690
84Fructose and mannose metabolism_Homo sapiens_hsa000510.83356206
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82699041
86Viral myocarditis_Homo sapiens_hsa054160.82597794
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81337503
88Glucagon signaling pathway_Homo sapiens_hsa049220.81138392
89Taste transduction_Homo sapiens_hsa047420.80953123
90Dilated cardiomyopathy_Homo sapiens_hsa054140.80108850
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79943078
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79478165
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76808723
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75939740
95Colorectal cancer_Homo sapiens_hsa052100.75875644
96HTLV-I infection_Homo sapiens_hsa051660.75782930
97Insulin signaling pathway_Homo sapiens_hsa049100.75590779
98Ether lipid metabolism_Homo sapiens_hsa005650.75166807
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73715145
100Fatty acid biosynthesis_Homo sapiens_hsa000610.73704278
101AMPK signaling pathway_Homo sapiens_hsa041520.72937868
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72720446
103Circadian rhythm_Homo sapiens_hsa047100.71796113
104Glutathione metabolism_Homo sapiens_hsa004800.70879115
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.70567144
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69646031
107Starch and sucrose metabolism_Homo sapiens_hsa005000.69430769
108p53 signaling pathway_Homo sapiens_hsa041150.69096389
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68568268
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68476082
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.67666035
112Sphingolipid metabolism_Homo sapiens_hsa006000.67538724
113Pyruvate metabolism_Homo sapiens_hsa006200.67112044
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67062628
115Prostate cancer_Homo sapiens_hsa052150.66299706
116Pentose phosphate pathway_Homo sapiens_hsa000300.66294471
117Amoebiasis_Homo sapiens_hsa051460.65882232
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65760143
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.65692509
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65107007
121Renal cell carcinoma_Homo sapiens_hsa052110.64284849
122beta-Alanine metabolism_Homo sapiens_hsa004100.63132257
123Insulin secretion_Homo sapiens_hsa049110.62759375
124Thyroid hormone synthesis_Homo sapiens_hsa049180.62195001
125Propanoate metabolism_Homo sapiens_hsa006400.61999412
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.61691629
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60254458
128Butanoate metabolism_Homo sapiens_hsa006500.59629621
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58971681
130Glycerolipid metabolism_Homo sapiens_hsa005610.57630599
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55863904
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53844472
133Melanogenesis_Homo sapiens_hsa049160.53744972
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53134253
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52938636
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52573382
137Phototransduction_Homo sapiens_hsa047440.52346492
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50946301
139Estrogen signaling pathway_Homo sapiens_hsa049150.50818954
140Rap1 signaling pathway_Homo sapiens_hsa040150.50326956
141HIF-1 signaling pathway_Homo sapiens_hsa040660.49788301
142Arachidonic acid metabolism_Homo sapiens_hsa005900.44767755

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