SOX14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of microtubule polymerization or depolymerization (GO:0031112)7.11312167
2negative regulation of cytosolic calcium ion concentration (GO:0051481)6.41209264
3pre-miRNA processing (GO:0031054)6.10216291
4pyrimidine nucleobase catabolic process (GO:0006208)6.04672741
5hyperosmotic salinity response (GO:0042538)5.93153576
6layer formation in cerebral cortex (GO:0021819)5.81695489
7regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.58127057
8dendritic spine morphogenesis (GO:0060997)5.42051641
9neuron cell-cell adhesion (GO:0007158)5.38296046
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19879686
11nucleobase catabolic process (GO:0046113)5.19200751
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.18933888
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.08022900
14vocalization behavior (GO:0071625)5.05846538
15microtubule polymerization or depolymerization (GO:0031109)4.96049624
16regulation of response to osmotic stress (GO:0047484)4.86662468
17ATP synthesis coupled proton transport (GO:0015986)4.86366804
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86366804
19negative regulation of microtubule polymerization (GO:0031115)4.81413780
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79096159
21neuron recognition (GO:0008038)4.75718847
22vascular smooth muscle contraction (GO:0014829)4.69386172
23presynaptic membrane assembly (GO:0097105)4.68169433
24neuronal action potential (GO:0019228)4.64122508
25proline transport (GO:0015824)4.59840337
26piRNA metabolic process (GO:0034587)4.46923286
27glutamate receptor signaling pathway (GO:0007215)4.46784003
28positive regulation of synapse assembly (GO:0051965)4.42282742
29regulation of glutamate receptor signaling pathway (GO:1900449)4.38029036
30tryptophan catabolic process (GO:0006569)4.33697085
31indole-containing compound catabolic process (GO:0042436)4.33697085
32indolalkylamine catabolic process (GO:0046218)4.33697085
33positive regulation of microtubule polymerization (GO:0031116)4.29304960
34regulation of energy homeostasis (GO:2000505)4.28542909
35ionotropic glutamate receptor signaling pathway (GO:0035235)4.27725333
36postsynaptic membrane organization (GO:0001941)4.26378004
37regulation of short-term neuronal synaptic plasticity (GO:0048172)4.26315022
38positive regulation of synaptic transmission, GABAergic (GO:0032230)4.19455242
39establishment of mitochondrion localization (GO:0051654)4.18266885
40presynaptic membrane organization (GO:0097090)4.14911819
41calcium ion import (GO:0070509)4.14833078
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.12534459
43spinal cord motor neuron differentiation (GO:0021522)4.12420142
44membrane depolarization during action potential (GO:0086010)4.03694388
45response to dietary excess (GO:0002021)3.99354208
46histone mRNA catabolic process (GO:0071044)3.98166803
47protein localization to synapse (GO:0035418)3.97877909
48regulation of respiratory system process (GO:0044065)3.94531600
49axonal fasciculation (GO:0007413)3.91929717
50response to histamine (GO:0034776)3.91710645
51cell communication involved in cardiac conduction (GO:0086065)3.88384166
52relaxation of smooth muscle (GO:0044557)3.88300839
53dopamine biosynthetic process (GO:0042416)3.87289465
54behavioral response to nicotine (GO:0035095)3.85608526
55glyoxylate metabolic process (GO:0046487)3.85313395
56hypotonic response (GO:0006971)3.84748016
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84599311
58ncRNA catabolic process (GO:0034661)3.84073500
59gamma-aminobutyric acid transport (GO:0015812)3.83365783
60protein insertion into membrane (GO:0051205)3.81666132
61cytoplasmic microtubule organization (GO:0031122)3.79986995
62dendrite morphogenesis (GO:0048813)3.79674390
63cell migration in hindbrain (GO:0021535)3.77438053
64regulation of timing of cell differentiation (GO:0048505)3.76642545
65establishment of integrated proviral latency (GO:0075713)3.73640202
66apical protein localization (GO:0045176)3.72054511
67organelle transport along microtubule (GO:0072384)3.68718094
68regulation of development, heterochronic (GO:0040034)3.68273958
69pteridine-containing compound biosynthetic process (GO:0042559)3.67484006
70mating behavior (GO:0007617)3.66989873
71sodium ion export (GO:0071436)3.66185971
72gonadal mesoderm development (GO:0007506)3.65594053
73neuron remodeling (GO:0016322)3.64905038
74serotonin metabolic process (GO:0042428)3.62187470
75transmission of nerve impulse (GO:0019226)3.61070048
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.56309317
77mitochondrion transport along microtubule (GO:0047497)3.56309317
78inositol phosphate catabolic process (GO:0071545)3.54888767
79cornea development in camera-type eye (GO:0061303)3.54637891
80positive regulation of protein depolymerization (GO:1901881)3.53265266
81neural tube formation (GO:0001841)3.53169049
82regulation of translational fidelity (GO:0006450)3.46190190
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.45482594
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44532202
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44111748
86synaptic vesicle exocytosis (GO:0016079)3.42014373
87retina layer formation (GO:0010842)3.39342584
88asymmetric protein localization (GO:0008105)3.38923182
89lens morphogenesis in camera-type eye (GO:0002089)3.37889237
90synaptic transmission, glutamatergic (GO:0035249)3.37707876
91cerebral cortex neuron differentiation (GO:0021895)3.36382106
92cell differentiation in spinal cord (GO:0021515)3.35509445
93startle response (GO:0001964)3.35325239
94kynurenine metabolic process (GO:0070189)3.35158438
95serotonin receptor signaling pathway (GO:0007210)3.35041107
96post-embryonic morphogenesis (GO:0009886)3.33299427
97axon extension (GO:0048675)3.31390571
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29720376
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29626822
100limb bud formation (GO:0060174)3.29087950
101neuronal stem cell maintenance (GO:0097150)3.26769011
102tryptophan metabolic process (GO:0006568)3.23615918
103neurotransmitter secretion (GO:0007269)3.22577014
104regulation of respiratory gaseous exchange (GO:0043576)3.22180607
105regulation of axon guidance (GO:1902667)3.21960078
106cerebellar Purkinje cell differentiation (GO:0021702)3.18483474
107cochlea development (GO:0090102)3.17225009
108regulation of synapse assembly (GO:0051963)3.16866864
109regulation of dendritic spine morphogenesis (GO:0061001)3.16571808
110short-term memory (GO:0007614)3.15845839
111membrane hyperpolarization (GO:0060081)3.12352535
112indole-containing compound metabolic process (GO:0042430)3.11842770
113neuron-neuron synaptic transmission (GO:0007270)3.10866052
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10647918
115regulation of synaptic vesicle exocytosis (GO:2000300)3.10191167
116heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.08110955
117kidney morphogenesis (GO:0060993)3.05678145
118central nervous system projection neuron axonogenesis (GO:0021952)3.05239163
119neuron maturation (GO:0042551)3.04427223
120positive regulation of dendritic spine development (GO:0060999)3.04190369
121synapse assembly (GO:0007416)3.03853246
122neurotransmitter transport (GO:0006836)3.01058874
123regulation of axon extension involved in axon guidance (GO:0048841)2.99683071
124regulation of filopodium assembly (GO:0051489)2.99238879
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.98321661
126establishment of planar polarity (GO:0001736)2.97993997
127establishment of tissue polarity (GO:0007164)2.97993997
128negative regulation of Notch signaling pathway (GO:0045746)2.97468839
129long-chain fatty acid biosynthetic process (GO:0042759)2.97179999
130lymphoid progenitor cell differentiation (GO:0002320)2.96204447
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94545754
132polyol catabolic process (GO:0046174)2.94315267
133prepulse inhibition (GO:0060134)2.93711822
134cellular sodium ion homeostasis (GO:0006883)2.93580398
135relaxation of cardiac muscle (GO:0055119)2.93455666
136neurotransmitter-gated ion channel clustering (GO:0072578)2.93369727
137sympathetic nervous system development (GO:0048485)2.93336438
138regulation of cAMP-dependent protein kinase activity (GO:2000479)2.92826000
139primary amino compound metabolic process (GO:1901160)2.92604279
140coenzyme A biosynthetic process (GO:0015937)2.91540624
141cell communication by electrical coupling (GO:0010644)2.90933870
142collecting duct development (GO:0072044)2.90384510
143establishment of viral latency (GO:0019043)2.88815106
144somatic stem cell maintenance (GO:0035019)2.88471785
145meiotic cell cycle (GO:0051321)2.88429437
146cell-cell junction maintenance (GO:0045217)2.88328490
147positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88232740
148urinary tract smooth muscle contraction (GO:0014848)2.87966788
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.87917688
150action potential (GO:0001508)2.87428373
151microtubule nucleation (GO:0007020)2.87036984
152protein polyglutamylation (GO:0018095)2.86914405
153synaptic vesicle maturation (GO:0016188)2.85951897
154coenzyme A metabolic process (GO:0015936)2.85934891
155epithelial structure maintenance (GO:0010669)2.84787225
156maternal behavior (GO:0042711)2.82437677
157positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.82408318
158dendrite development (GO:0016358)2.81578460
159neuronal action potential propagation (GO:0019227)2.81263659
160glial cell proliferation (GO:0014009)2.80950156
161neurotransmitter uptake (GO:0001504)2.80763133
162indolalkylamine metabolic process (GO:0006586)2.80102423
163inner ear receptor stereocilium organization (GO:0060122)2.79614716
164regulation of synapse structural plasticity (GO:0051823)2.79508726
165adult feeding behavior (GO:0008343)2.79180411
166regulation of synaptic transmission, GABAergic (GO:0032228)2.77848867
167viral transcription (GO:0019083)2.77601680
168cardiovascular system development (GO:0072358)2.77566485
169respiratory electron transport chain (GO:0022904)2.76747789
170negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75596403
171positive regulation of action potential (GO:0045760)2.73713525
172thalamus development (GO:0021794)2.73470547
173forebrain neuron development (GO:0021884)2.73177506
174positive regulation of synapse maturation (GO:0090129)2.71862459
175electron transport chain (GO:0022900)2.71752968
176cell junction maintenance (GO:0034331)2.71569720
177synapse organization (GO:0050808)2.71121752
178homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.70916455
179retinal ganglion cell axon guidance (GO:0031290)2.70684283
180regulation of microtubule polymerization (GO:0031113)2.68878613
181regulation of glutamate secretion (GO:0014048)2.68484137
182regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68392741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.73922388
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.88817282
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.74340441
4GBX2_23144817_ChIP-Seq_PC3_Human3.52827109
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01005430
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.96921259
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77321391
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73305345
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73296134
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.72112235
11ZNF274_21170338_ChIP-Seq_K562_Hela2.60341406
12TAF15_26573619_Chip-Seq_HEK293_Human2.60049624
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54457939
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54457939
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52711715
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48874536
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.43846423
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43193682
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40701805
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.31515794
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.25097447
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16353982
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10210751
24* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08881094
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06452340
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03723321
27* CBX2_27304074_Chip-Seq_ESCs_Mouse2.01107801
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.96557844
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.94909527
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.86682342
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77097579
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71017877
33AR_21572438_ChIP-Seq_LNCaP_Human1.66777886
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.65331517
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63327671
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.61265394
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56837588
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53467783
39* P300_19829295_ChIP-Seq_ESCs_Human1.52976490
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51534959
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50386840
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49554290
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.49506972
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49171141
45FUS_26573619_Chip-Seq_HEK293_Human1.48800347
46ER_23166858_ChIP-Seq_MCF-7_Human1.46994477
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.44950469
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.38494741
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36937130
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.36819252
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36140533
52SMAD4_21799915_ChIP-Seq_A2780_Human1.35672863
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34223631
54* RNF2_27304074_Chip-Seq_NSC_Mouse1.32212978
55EGR1_19032775_ChIP-ChIP_M12_Human1.31871711
56* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29876862
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27793239
58* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27526353
59DROSHA_22980978_ChIP-Seq_HELA_Human1.25451427
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25401953
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25401953
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25401953
63HTT_18923047_ChIP-ChIP_STHdh_Human1.25298505
64IRF1_19129219_ChIP-ChIP_H3396_Human1.24101400
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23486745
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22136280
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.21692259
68* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21640270
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20457404
70* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20438295
71TP53_22573176_ChIP-Seq_HFKS_Human1.20322221
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18152610
73* AR_25329375_ChIP-Seq_VCAP_Human1.17691477
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.17042715
75AHR_22903824_ChIP-Seq_MCF-7_Human1.17009855
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16857312
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16832545
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.16832545
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16547561
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14981808
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.13840825
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12973536
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11739785
84* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11188895
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08927899
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08903688
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08878307
88EWS_26573619_Chip-Seq_HEK293_Human1.08335123
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.06308724
90STAT3_18555785_ChIP-Seq_MESCs_Mouse1.05415215
91VDR_22108803_ChIP-Seq_LS180_Human1.05229502
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04866594
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04399730
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03161460
95* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02846127
96IGF1R_20145208_ChIP-Seq_DFB_Human1.01316086
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01053367
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00769884
99E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00473033
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00021840
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00021840
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99231036
103TP53_18474530_ChIP-ChIP_U2OS_Human0.99120209
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97354862
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.97313130
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96342624
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96100166
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96042155
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95923742
110* RUNX2_22187159_ChIP-Seq_PCA_Human0.95460087
111KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95247065
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.94355033
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94325424
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94132298
115* STAT3_23295773_ChIP-Seq_U87_Human0.94098466
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93967310
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93634752
118* JUN_21703547_ChIP-Seq_K562_Human0.91609153
119POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.88409701
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87554219
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87508934
122* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87335999
123CBP_20019798_ChIP-Seq_JUKART_Human0.84192827
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84192827
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83377729
126AR_19668381_ChIP-Seq_PC3_Human0.83253976
127BCAT_22108803_ChIP-Seq_LS180_Human0.82752090
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.79503955
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78898301
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78862749
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.78735814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.68921973
2MP0000569_abnormal_digit_pigmentation4.69382778
3MP0005423_abnormal_somatic_nervous4.62846357
4MP0006276_abnormal_autonomic_nervous4.12992606
5MP0009379_abnormal_foot_pigmentation3.97931016
6MP0004133_heterotaxia3.52297280
7MP0008995_early_reproductive_senescence3.49117524
8MP0003635_abnormal_synaptic_transmissio3.16069466
9MP0001984_abnormal_olfaction2.96857660
10MP0005645_abnormal_hypothalamus_physiol2.80293937
11MP0001188_hyperpigmentation2.79994024
12MP0004859_abnormal_synaptic_plasticity2.73326951
13MP0009046_muscle_twitch2.61476439
14MP0009745_abnormal_behavioral_response2.58906463
15MP0000778_abnormal_nervous_system2.51263304
16MP0001968_abnormal_touch/_nociception2.50108815
17MP0009278_abnormal_bone_marrow2.48193746
18MP0001486_abnormal_startle_reflex2.40521520
19MP0002064_seizures2.37270239
20MP0002184_abnormal_innervation2.36729626
21MP0002272_abnormal_nervous_system2.33782576
22MP0002063_abnormal_learning/memory/cond2.32915529
23MP0002572_abnormal_emotion/affect_behav2.28622622
24MP0002734_abnormal_mechanical_nocicepti2.18199752
25MP0003122_maternal_imprinting2.15533059
26MP0002733_abnormal_thermal_nociception2.05735476
27MP0004270_analgesia1.98678356
28MP0002653_abnormal_ependyma_morphology1.95335170
29MP0002102_abnormal_ear_morphology1.93097842
30MP0004142_abnormal_muscle_tone1.91226150
31MP0001501_abnormal_sleep_pattern1.88411328
32MP0002067_abnormal_sensory_capabilities1.87798774
33MP0002736_abnormal_nociception_after1.77027326
34MP0005409_darkened_coat_color1.70903382
35MP0002557_abnormal_social/conspecific_i1.65516088
36MP0004742_abnormal_vestibular_system1.64646254
37MP0004147_increased_porphyrin_level1.64374232
38MP0001440_abnormal_grooming_behavior1.63717992
39MP0001970_abnormal_pain_threshold1.63510862
40MP0001529_abnormal_vocalization1.60557969
41MP0002638_abnormal_pupillary_reflex1.60165741
42MP0004924_abnormal_behavior1.58778157
43MP0005386_behavior/neurological_phenoty1.58778157
44MP0002876_abnormal_thyroid_physiology1.58295253
45MP0004811_abnormal_neuron_physiology1.56365999
46MP0003879_abnormal_hair_cell1.48797948
47MP0005187_abnormal_penis_morphology1.45881608
48MP0002882_abnormal_neuron_morphology1.38802925
49MP0001502_abnormal_circadian_rhythm1.34852759
50MP0002282_abnormal_trachea_morphology1.30758015
51MP0003890_abnormal_embryonic-extraembry1.29916282
52MP0003329_amyloid_beta_deposits1.29718941
53MP0001905_abnormal_dopamine_level1.29615081
54MP0002066_abnormal_motor_capabilities/c1.27469764
55MP0002751_abnormal_autonomic_nervous1.23222954
56MP0003123_paternal_imprinting1.21906113
57MP0003942_abnormal_urinary_system1.19677388
58MP0002735_abnormal_chemical_nociception1.18873726
59MP0002152_abnormal_brain_morphology1.18556806
60MP0004084_abnormal_cardiac_muscle1.16072290
61MP0000467_abnormal_esophagus_morphology1.15186923
62MP0003121_genomic_imprinting1.14583133
63MP0006072_abnormal_retinal_apoptosis1.14330931
64MP0000955_abnormal_spinal_cord1.12678785
65MP0006035_abnormal_mitochondrial_morpho1.11169564
66MP0003724_increased_susceptibility_to1.10472584
67MP0000751_myopathy1.08468565
68MP0005174_abnormal_tail_pigmentation1.04318259
69MP0008775_abnormal_heart_ventricle1.03853042
70MP0000750_abnormal_muscle_regeneration1.02930487
71MP0003861_abnormal_nervous_system1.01438316
72MP0005394_taste/olfaction_phenotype1.00675973
73MP0005499_abnormal_olfactory_system1.00675973
74MP0000427_abnormal_hair_cycle1.00269129
75MP0008569_lethality_at_weaning0.98736186
76MP0004085_abnormal_heartbeat0.98242933
77MP0000026_abnormal_inner_ear0.98016115
78MP0001485_abnormal_pinna_reflex0.96558006
79MP0000631_abnormal_neuroendocrine_gland0.96082688
80MP0002909_abnormal_adrenal_gland0.94911527
81MP0003136_yellow_coat_color0.94179462
82MP0002752_abnormal_somatic_nervous0.93562061
83MP0006292_abnormal_olfactory_placode0.90225590
84MP0010386_abnormal_urinary_bladder0.88997976
85MP0002229_neurodegeneration0.87990728
86MP0000647_abnormal_sebaceous_gland0.87444147
87MP0003315_abnormal_perineum_morphology0.86714894
88MP0002837_dystrophic_cardiac_calcinosis0.85736775
89MP0005253_abnormal_eye_physiology0.85246287
90MP0004883_abnormal_blood_vessel0.84262647
91MP0003632_abnormal_nervous_system0.84248263
92MP0000462_abnormal_digestive_system0.83278982
93MP0001346_abnormal_lacrimal_gland0.80838882
94MP0003385_abnormal_body_wall0.80117999
95MP0001963_abnormal_hearing_physiology0.79058655
96MP0005551_abnormal_eye_electrophysiolog0.78763566
97MP0000015_abnormal_ear_pigmentation0.78757803
98MP0002254_reproductive_system_inflammat0.78475021
99MP0003938_abnormal_ear_development0.77273879
100MP0009053_abnormal_anal_canal0.75876344
101MP0008260_abnormal_autophagy0.74908219
102MP0003786_premature_aging0.74458365
103MP0001542_abnormal_bone_strength0.74430250
104MP0002009_preneoplasia0.74006690
105MP0004885_abnormal_endolymph0.73131551
106MP0005448_abnormal_energy_balance0.71899656
107MP0003634_abnormal_glial_cell0.70246242
108MP0004130_abnormal_muscle_cell0.70159097
109MP0002098_abnormal_vibrissa_morphology0.69717964
110MP0001943_abnormal_respiration0.67931705
111MP0002082_postnatal_lethality0.67105013
112MP0010770_preweaning_lethality0.67105013
113MP0008789_abnormal_olfactory_epithelium0.66937834
114MP0001177_atelectasis0.66551944
115MP0001299_abnormal_eye_distance/0.64734865
116MP0002069_abnormal_eating/drinking_beha0.63839515
117MP0010769_abnormal_survival0.63252202
118MP0003221_abnormal_cardiomyocyte_apopto0.62743347
119MP0005535_abnormal_body_temperature0.62575946
120MP0002163_abnormal_gland_morphology0.61799104
121MP0002928_abnormal_bile_duct0.61536239
122MP0000538_abnormal_urinary_bladder0.60697856
123MP0000604_amyloidosis0.60621283
124MP0004484_altered_response_of0.60238194
125MP0010768_mortality/aging0.58618592
126MP0000534_abnormal_ureter_morphology0.58254055
127MP0005266_abnormal_metabolism0.57930265
128MP0002081_perinatal_lethality0.57828600
129MP0003567_abnormal_fetal_cardiomyocyte0.57629369
130MP0003690_abnormal_glial_cell0.57274493
131MP0005646_abnormal_pituitary_gland0.56886664
132MP0002822_catalepsy0.55849567
133MP0004272_abnormal_basement_membrane0.55735801
134MP0002234_abnormal_pharynx_morphology0.55460563
135MP0001986_abnormal_taste_sensitivity0.55194265
136MP0003137_abnormal_impulse_conducting0.54710722
137MP0008770_decreased_survivor_rate0.53940095

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)6.02368673
2Hand muscle atrophy (HP:0009130)5.51115071
3Carpal bone hypoplasia (HP:0001498)5.34748659
4Aplasia of the musculature (HP:0100854)5.33576581
5Hip dysplasia (HP:0001385)5.25716457
6Fetal akinesia sequence (HP:0001989)5.09113687
7Hip contracture (HP:0003273)4.99058255
8Muscle fiber splitting (HP:0003555)4.82642021
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.82511299
10Barrel-shaped chest (HP:0001552)4.56878899
11Absence seizures (HP:0002121)4.50057033
12Spinal muscular atrophy (HP:0007269)4.43793571
13Focal seizures (HP:0007359)4.38627657
14Diaphragmatic weakness (HP:0009113)4.23755146
15Sleep apnea (HP:0010535)4.20670204
16Progressive cerebellar ataxia (HP:0002073)4.09915680
17Distal upper limb amyotrophy (HP:0007149)4.08804889
18Upper limb amyotrophy (HP:0009129)4.08804889
19Stridor (HP:0010307)3.99825464
20Dialeptic seizures (HP:0011146)3.96883934
21Febrile seizures (HP:0002373)3.96128993
22Myokymia (HP:0002411)3.84719288
23Down-sloping shoulders (HP:0200021)3.75053690
24Abnormality of the vocal cords (HP:0008777)3.71295313
25Abnormality of the middle phalanges of the toes (HP:0010183)3.66597916
26Flat acetabular roof (HP:0003180)3.60230263
27Polyphagia (HP:0002591)3.53595058
28Obstructive sleep apnea (HP:0002870)3.46237286
29Limited hip movement (HP:0008800)3.44984520
30Limb-girdle muscle atrophy (HP:0003797)3.35962063
31Focal motor seizures (HP:0011153)3.34574742
32Cerebral inclusion bodies (HP:0100314)3.33052524
33Postural tremor (HP:0002174)3.31987350
34Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.31810172
35Nonprogressive disorder (HP:0003680)3.29263247
36Mutism (HP:0002300)3.27251327
37Amyotrophic lateral sclerosis (HP:0007354)3.23769459
38Aplasia/Hypoplasia involving the musculature (HP:0001460)3.22224516
39Supranuclear gaze palsy (HP:0000605)3.20954920
40Generalized tonic-clonic seizures (HP:0002069)3.20290367
41Limb dystonia (HP:0002451)3.20076100
42Truncal ataxia (HP:0002078)3.19316424
43Neurofibrillary tangles (HP:0002185)3.18493450
44Broad-based gait (HP:0002136)3.14791575
45Severe visual impairment (HP:0001141)3.12337787
46Disproportionate short-trunk short stature (HP:0003521)3.10745278
47Drooling (HP:0002307)3.08019505
48Excessive salivation (HP:0003781)3.08019505
49Small hand (HP:0200055)3.05357290
50Hemiparesis (HP:0001269)3.02003735
51Cortical dysplasia (HP:0002539)3.00716462
52Abdominal situs inversus (HP:0003363)2.92356081
53Abnormality of abdominal situs (HP:0011620)2.92356081
54Distal lower limb muscle weakness (HP:0009053)2.91506559
55Amblyopia (HP:0000646)2.90834132
56Metaphyseal irregularity (HP:0003025)2.81789029
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81146679
58Abnormality of alanine metabolism (HP:0010916)2.81146679
59Hyperalaninemia (HP:0003348)2.81146679
60Midline defect of the nose (HP:0004122)2.79068938
61True hermaphroditism (HP:0010459)2.77987109
62Ankle clonus (HP:0011448)2.74972642
63Hypoplasia of the odontoid process (HP:0003311)2.73871489
64Abnormality of the labia minora (HP:0012880)2.70128645
65Difficulty running (HP:0009046)2.68843774
66Knee flexion contracture (HP:0006380)2.67920591
67Exotropia (HP:0000577)2.67037174
68Supernumerary spleens (HP:0009799)2.66486453
69Progressive inability to walk (HP:0002505)2.64065262
70Pancreatic fibrosis (HP:0100732)2.60089693
71Epiphyseal dysplasia (HP:0002656)2.58243836
72Scapular winging (HP:0003691)2.57553171
73Pancreatic cysts (HP:0001737)2.54063532
74Inappropriate behavior (HP:0000719)2.51814842
75Esotropia (HP:0000565)2.50636077
76Urinary urgency (HP:0000012)2.49683062
77Spinal cord compression (HP:0002176)2.49378937
78Acute necrotizing encephalopathy (HP:0006965)2.47779444
79Torticollis (HP:0000473)2.46918496
80Nuclear cataract (HP:0100018)2.43991360
81Anxiety (HP:0000739)2.43017214
82Agitation (HP:0000713)2.42377709
83Abnormal pupillary function (HP:0007686)2.40720926
84Anencephaly (HP:0002323)2.40506338
85Scanning speech (HP:0002168)2.39009687
86Failure to thrive in infancy (HP:0001531)2.38423562
87Shoulder girdle muscle weakness (HP:0003547)2.37693319
88Visual hallucinations (HP:0002367)2.36355940
89Lower limb asymmetry (HP:0100559)2.32779559
90Abnormality of the distal phalanges of the toes (HP:0010182)2.30626394
91Progressive macrocephaly (HP:0004481)2.29079580
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28166573
93Abnormal mitochondria in muscle tissue (HP:0008316)2.28007521
94Abnormality of the intervertebral disk (HP:0005108)2.25170132
95Morphological abnormality of the middle ear (HP:0008609)2.24607132
96Rimmed vacuoles (HP:0003805)2.23659336
97Abnormality of the odontoid process (HP:0003310)2.23137115
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.22624292
99Abnormal eating behavior (HP:0100738)2.21186681
100Termporal pattern (HP:0011008)2.19139280
101Insidious onset (HP:0003587)2.19139280
102Akinesia (HP:0002304)2.19032173
103Facial hemangioma (HP:0000329)2.18119909
104Abnormality of the corticospinal tract (HP:0002492)2.16032369
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15529215
106Dysmetria (HP:0001310)2.15476476
107Hypoparathyroidism (HP:0000829)2.14342574
108Abnormality of the musculature of the hand (HP:0001421)2.14101090
109Sex reversal (HP:0012245)2.13894361
110Abnormal sex determination (HP:0012244)2.13894361
111Status epilepticus (HP:0002133)2.11959768
112Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10430169
113Hypoplasia of the brainstem (HP:0002365)2.10430169
114Abnormality of secondary sexual hair (HP:0009888)2.10185058
115Abnormality of the axillary hair (HP:0100134)2.10185058
116Inability to walk (HP:0002540)2.09964402
117Short femoral neck (HP:0100864)2.09850651
118Short tibia (HP:0005736)2.09744248
119Sparse lateral eyebrow (HP:0005338)2.09594505
120Molar tooth sign on MRI (HP:0002419)2.08970994
121Abnormality of midbrain morphology (HP:0002418)2.08970994
122Protruding tongue (HP:0010808)2.08434252
123EEG with generalized epileptiform discharges (HP:0011198)2.07912228
124Horizontal nystagmus (HP:0000666)2.07891623
125High anterior hairline (HP:0009890)2.07315459
126Abnormality of the parathyroid morphology (HP:0011766)2.06111915
127Generalized myoclonic seizures (HP:0002123)2.05518598
128Hypsarrhythmia (HP:0002521)2.03306599
129Long foot (HP:0001833)2.02919547
130Abnormal number of incisors (HP:0011064)2.00449181
131Humeroradial synostosis (HP:0003041)2.00385952
132Synostosis involving the elbow (HP:0003938)2.00385952
133Morphological abnormality of the pyramidal tract (HP:0002062)2.00174529
134Epileptiform EEG discharges (HP:0011182)1.99072624
135Reticulocytopenia (HP:0001896)1.98897495
136Hypothermia (HP:0002045)1.98455161
137Epidermoid cyst (HP:0200040)1.97486364
138Action tremor (HP:0002345)1.96968132
139Gowers sign (HP:0003391)1.96706101
140Optic disc pallor (HP:0000543)1.95473044
141Cystic liver disease (HP:0006706)1.94783792
142Apathy (HP:0000741)1.94749841
143Abnormality of salivation (HP:0100755)1.94106076
144Diplopia (HP:0000651)1.93430143
145Abnormality of binocular vision (HP:0011514)1.93430143
146Papillary thyroid carcinoma (HP:0002895)1.93319506
147Psychosis (HP:0000709)1.91972015
148Dysdiadochokinesis (HP:0002075)1.91590932
149Hepatoblastoma (HP:0002884)1.90870094
150Epileptic encephalopathy (HP:0200134)1.90619011
151Abnormal vertebral ossification (HP:0100569)1.88203949
152Intellectual disability, moderate (HP:0002342)1.87814971
153Acute encephalopathy (HP:0006846)1.87503130
154Open mouth (HP:0000194)1.87333262
155Heterochromia iridis (HP:0001100)1.85775935
156Alacrima (HP:0000522)1.85069055
157Neuronal loss in central nervous system (HP:0002529)1.84588227
158Abnormality of ocular smooth pursuit (HP:0000617)1.83790227
159Absent septum pellucidum (HP:0001331)1.83722944
160Spastic gait (HP:0002064)1.83679893
161Sacral dimple (HP:0000960)1.83005515
162Abnormality of the pubic bones (HP:0003172)1.82330004
163Pheochromocytoma (HP:0002666)1.82272778
164Hyperventilation (HP:0002883)1.82080916
165Testicular neoplasm (HP:0010788)1.81681382
166Macroorchidism (HP:0000053)1.81517764
167Lower limb amyotrophy (HP:0007210)1.81448268
168Impaired social interactions (HP:0000735)1.81049494
169Preaxial hand polydactyly (HP:0001177)1.80681484
170Achilles tendon contracture (HP:0001771)1.79601169
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79461510
172Sclerocornea (HP:0000647)1.78380200
173Abnormality of carpal bone ossification (HP:0006257)1.77260585
174Craniofacial dystonia (HP:0012179)1.77241547
175Lissencephaly (HP:0001339)1.73571280
176Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.72537993
177Intestinal atresia (HP:0011100)1.71963745
178Abnormality of the shoulder girdle musculature (HP:0001435)1.71697894
179Gastrointestinal atresia (HP:0002589)1.70010869
180Esophageal atresia (HP:0002032)1.68292371
181Nephronophthisis (HP:0000090)1.68060742
182Aplasia/hypoplasia of the femur (HP:0005613)1.67333906
183Absent toe (HP:0010760)1.66342383
184Abnormal hand bone ossification (HP:0010660)1.66151252
185Oculomotor apraxia (HP:0000657)1.64469183
186Genu varum (HP:0002970)1.62491969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.95814756
2GRK74.34850320
3MAP4K23.89072303
4NTRK23.78179367
5FRK3.61986647
6MAP3K93.60946004
7NTRK33.58869491
8CASK3.24446837
9MAPK132.91458568
10EPHA32.45107338
11PHKG22.43782562
12PHKG12.43782562
13RPS6KA42.37240624
14MAP3K72.36133347
15TAOK12.31314835
16DYRK22.21968421
17TNIK2.16344195
18TAOK32.01334461
19CDK82.00244362
20ACVR1B1.98370704
21UHMK11.98138772
22NME11.92199453
23KSR11.87647996
24MAP3K41.83001677
25LATS21.81755931
26IRAK11.72187876
27CLK11.69442480
28MINK11.66217963
29MAPK151.63554676
30EPHB11.59787731
31INSRR1.58218692
32PNCK1.52831090
33SIK21.52516257
34ICK1.46358606
35MAPKAPK51.36549526
36ERBB31.36429268
37PLK41.31422880
38MAP2K71.28980930
39WNK31.28848885
40EPHA41.28441625
41RPS6KA51.26803968
42ADRBK11.25260250
43DAPK21.23815340
44MAP2K41.22873815
45TRIM281.21790306
46FGR1.19454027
47CDK31.18333664
48GRK51.17315416
49FER1.15776073
50PDK21.13949748
51MAP3K111.13916843
52BRD41.10055336
53CDK51.06862413
54EPHB21.05854592
55LIMK11.02516372
56DYRK1A1.01357039
57STK390.98846108
58FGFR20.97843822
59CSNK1G20.95999573
60CAMK1G0.95308506
61TYRO30.92932702
62PAK30.92844191
63MAPK120.88779208
64WNK40.88761836
65BMPR1B0.87448901
66CAMK2A0.86561747
67CDK190.84470578
68RIPK10.82028276
69CAMK2B0.80796279
70CSNK1G30.78656296
71GRK60.77881427
72CDK140.76723850
73STK110.76540002
74CAMK1D0.75883363
75IRAK20.75448300
76BCR0.74185008
77FES0.72954477
78KSR20.72861674
79CDK180.71647498
80CDK150.71640902
81MAP3K20.69013821
82PRKD30.68316256
83PLK20.68067355
84TSSK60.67923303
85CSNK1A1L0.65323494
86CDK11A0.64949107
87TLK10.64846516
88PRKCG0.64148059
89PAK60.63272636
90CCNB10.62005887
91LMTK20.61412151
92MAP3K120.60939539
93ADRBK20.60306591
94MAPK40.58887264
95PKN10.58782518
96SRPK10.58200083
97PRKCZ0.56726533
98MKNK20.55176693
99NTRK10.53866694
100GRK10.51568195
101SIK10.50652100
102CSNK1G10.49933246
103MAPK90.48420705
104AKT30.48139625
105CAMK40.47820010
106WEE10.47599917
107DAPK10.46995702
108BRSK20.46682698
109TAOK20.46593449
110ZAK0.46032607
111PRKG10.45492185
112MARK20.45104769
113PRKCE0.44280254
114STK380.44158362
115TGFBR10.43791423
116ERBB20.43054273
117MKNK10.42472811
118ERBB40.41944360
119PRKACA0.41937505
120CAMK10.41772030
121PRKAA20.39039474
122CAMK2G0.38481302
123PRKCB0.37005173
124DYRK1B0.36681631
125OXSR10.36622139
126ARAF0.36492909
127PRKAA10.36176256
128NUAK10.35997746
129PRKACG0.35272516
130CSNK1D0.34555505
131MAP3K100.34523290
132DYRK30.33945152
133CSNK1E0.33000603
134RET0.32361538
135ALK0.32227562
136STK40.31214077
137LYN0.30165719
138SGK10.29934891
139GSK3A0.29806672
140PRKCA0.29622303
141GSK3B0.29463772
142CDK10.29456704
143SGK4940.29267445
144SGK2230.29267445
145ROCK20.28991332

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.63428664
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00285337
3Regulation of autophagy_Homo sapiens_hsa041402.67553651
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66011225
5Serotonergic synapse_Homo sapiens_hsa047262.59232115
6Oxidative phosphorylation_Homo sapiens_hsa001902.57987241
7GABAergic synapse_Homo sapiens_hsa047272.45021310
8Parkinsons disease_Homo sapiens_hsa050122.43751011
9Glutamatergic synapse_Homo sapiens_hsa047242.35427776
10Alzheimers disease_Homo sapiens_hsa050102.11584888
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05219593
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95220976
13Synaptic vesicle cycle_Homo sapiens_hsa047211.93134516
14Cardiac muscle contraction_Homo sapiens_hsa042601.90766581
15Butanoate metabolism_Homo sapiens_hsa006501.87045025
16Taste transduction_Homo sapiens_hsa047421.85833173
17Morphine addiction_Homo sapiens_hsa050321.85492783
18Long-term potentiation_Homo sapiens_hsa047201.78225256
19Long-term depression_Homo sapiens_hsa047301.77469061
20Axon guidance_Homo sapiens_hsa043601.76830761
21Dopaminergic synapse_Homo sapiens_hsa047281.76727741
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76507512
23Cocaine addiction_Homo sapiens_hsa050301.74096519
24Huntingtons disease_Homo sapiens_hsa050161.69865244
25Amphetamine addiction_Homo sapiens_hsa050311.62904436
26Circadian rhythm_Homo sapiens_hsa047101.60066438
27Ribosome_Homo sapiens_hsa030101.57173381
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53875654
29Circadian entrainment_Homo sapiens_hsa047131.51662773
30Fatty acid biosynthesis_Homo sapiens_hsa000611.50886613
31Renin secretion_Homo sapiens_hsa049241.48719883
32Gap junction_Homo sapiens_hsa045401.48300202
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42554957
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33376690
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33169488
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28173483
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27050120
38GnRH signaling pathway_Homo sapiens_hsa049121.25966618
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25070503
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24602019
41Linoleic acid metabolism_Homo sapiens_hsa005911.23122641
42Melanogenesis_Homo sapiens_hsa049161.22571784
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22111274
44Calcium signaling pathway_Homo sapiens_hsa040201.21265539
45Salivary secretion_Homo sapiens_hsa049701.19871678
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18331885
47Cholinergic synapse_Homo sapiens_hsa047251.16282004
48Oxytocin signaling pathway_Homo sapiens_hsa049211.15902766
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14441636
50Vibrio cholerae infection_Homo sapiens_hsa051101.14288714
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12148894
52Prion diseases_Homo sapiens_hsa050201.11453075
53Gastric acid secretion_Homo sapiens_hsa049711.10312621
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09616763
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08803881
56Olfactory transduction_Homo sapiens_hsa047401.08414629
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08105201
58Protein export_Homo sapiens_hsa030601.06678408
59Phenylalanine metabolism_Homo sapiens_hsa003601.06306216
60Tyrosine metabolism_Homo sapiens_hsa003501.05998451
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.03287402
62Insulin secretion_Homo sapiens_hsa049110.99535050
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96771032
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96736917
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96667188
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94893898
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93892496
68Estrogen signaling pathway_Homo sapiens_hsa049150.91735657
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90717127
70Basal transcription factors_Homo sapiens_hsa030220.90197344
71ErbB signaling pathway_Homo sapiens_hsa040120.86702187
72Type II diabetes mellitus_Homo sapiens_hsa049300.85869745
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83830166
74ABC transporters_Homo sapiens_hsa020100.78836955
75Peroxisome_Homo sapiens_hsa041460.77899881
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77717712
77Chemical carcinogenesis_Homo sapiens_hsa052040.76125714
78Collecting duct acid secretion_Homo sapiens_hsa049660.76060824
79Base excision repair_Homo sapiens_hsa034100.75457843
80Glucagon signaling pathway_Homo sapiens_hsa049220.74459755
81Dorso-ventral axis formation_Homo sapiens_hsa043200.72172323
82Renal cell carcinoma_Homo sapiens_hsa052110.68074597
83Viral myocarditis_Homo sapiens_hsa054160.67302879
84Dilated cardiomyopathy_Homo sapiens_hsa054140.66967922
85Proteasome_Homo sapiens_hsa030500.66360378
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.66282393
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65114574
88Colorectal cancer_Homo sapiens_hsa052100.64695931
89Sulfur metabolism_Homo sapiens_hsa009200.63960388
90cAMP signaling pathway_Homo sapiens_hsa040240.63810786
91Hippo signaling pathway_Homo sapiens_hsa043900.63538137
92Wnt signaling pathway_Homo sapiens_hsa043100.61865416
93VEGF signaling pathway_Homo sapiens_hsa043700.58632147
94Steroid biosynthesis_Homo sapiens_hsa001000.57485860
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55240797
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54021528
97Tryptophan metabolism_Homo sapiens_hsa003800.53855571
98Hedgehog signaling pathway_Homo sapiens_hsa043400.53193580
99MAPK signaling pathway_Homo sapiens_hsa040100.53141474
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52888620
101Insulin signaling pathway_Homo sapiens_hsa049100.51849604
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.51523223
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.51127266
104Fatty acid elongation_Homo sapiens_hsa000620.50002988
105Glioma_Homo sapiens_hsa052140.49330461
106TGF-beta signaling pathway_Homo sapiens_hsa043500.47952185
107RNA degradation_Homo sapiens_hsa030180.47431936
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46821609
109Mineral absorption_Homo sapiens_hsa049780.46597772
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44999544
111Basal cell carcinoma_Homo sapiens_hsa052170.44724875
112Alcoholism_Homo sapiens_hsa050340.40962818
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39828533
114Protein digestion and absorption_Homo sapiens_hsa049740.39527742
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38857143
116Ether lipid metabolism_Homo sapiens_hsa005650.38135218
117Metabolic pathways_Homo sapiens_hsa011000.36520100
118Arginine and proline metabolism_Homo sapiens_hsa003300.36372681
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.35718555
120Oocyte meiosis_Homo sapiens_hsa041140.34973160
121Nitrogen metabolism_Homo sapiens_hsa009100.34779752
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.34094412
123Bile secretion_Homo sapiens_hsa049760.33938445
124Sulfur relay system_Homo sapiens_hsa041220.33541659
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33437768
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33199033
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.33189385
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32785887
129Endometrial cancer_Homo sapiens_hsa052130.31849680
130Lysine degradation_Homo sapiens_hsa003100.31699743
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30783627
132beta-Alanine metabolism_Homo sapiens_hsa004100.29438415
133African trypanosomiasis_Homo sapiens_hsa051430.29309549
134Histidine metabolism_Homo sapiens_hsa003400.28886565
135Selenocompound metabolism_Homo sapiens_hsa004500.28727112
136Fat digestion and absorption_Homo sapiens_hsa049750.28057343
137Phototransduction_Homo sapiens_hsa047440.27568821
138Phagosome_Homo sapiens_hsa041450.26385360
139AMPK signaling pathway_Homo sapiens_hsa041520.26219281
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26013262
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25059203
142Ras signaling pathway_Homo sapiens_hsa040140.24820684

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