SOX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.53110551
2desmosome organization (GO:0002934)7.70905741
3purine nucleobase biosynthetic process (GO:0009113)6.86007723
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.31893090
5ribosome assembly (GO:0042255)6.15954220
6nucleobase biosynthetic process (GO:0046112)6.08111226
7establishment of skin barrier (GO:0061436)5.91403074
8negative regulation of keratinocyte proliferation (GO:0010839)5.77072356
9mitotic metaphase plate congression (GO:0007080)5.73239072
10regulation of water loss via skin (GO:0033561)5.60714146
11regulation of retinoic acid receptor signaling pathway (GO:0048385)5.49359595
12keratinocyte proliferation (GO:0043616)5.19051748
13keratinization (GO:0031424)5.16525957
14ribosome biogenesis (GO:0042254)4.97692085
15regulation of spindle organization (GO:0090224)4.95674445
16folic acid metabolic process (GO:0046655)4.93850290
17vitamin transmembrane transport (GO:0035461)4.78156945
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75390819
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.72378678
20rRNA modification (GO:0000154)4.64003294
21DNA replication checkpoint (GO:0000076)4.58280872
22termination of RNA polymerase III transcription (GO:0006386)4.55713539
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.55713539
24proteasome assembly (GO:0043248)4.44706165
25metaphase plate congression (GO:0051310)4.36759442
26formation of translation preinitiation complex (GO:0001731)4.36312798
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.33791344
28folic acid transport (GO:0015884)4.32750144
29regulation of DNA methylation (GO:0044030)4.30809379
30termination of RNA polymerase I transcription (GO:0006363)4.26414920
31transcription elongation from RNA polymerase I promoter (GO:0006362)4.23988025
32regulation of keratinocyte proliferation (GO:0010837)4.22134263
33keratinocyte development (GO:0003334)4.17775794
34transcription from RNA polymerase I promoter (GO:0006360)4.12441698
35regulation of mitotic spindle organization (GO:0060236)4.08813498
36positive regulation of chromosome segregation (GO:0051984)4.08021423
37lung-associated mesenchyme development (GO:0060484)4.04397202
387-methylguanosine mRNA capping (GO:0006370)4.02567268
39maturation of SSU-rRNA (GO:0030490)4.00600686
40intestinal epithelial cell development (GO:0060576)4.00206455
41ribonucleoprotein complex biogenesis (GO:0022613)3.95725864
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91725761
43DNA deamination (GO:0045006)3.90779308
44RNA capping (GO:0036260)3.88478252
457-methylguanosine RNA capping (GO:0009452)3.88478252
46GMP metabolic process (GO:0046037)3.81030355
47transcription initiation from RNA polymerase I promoter (GO:0006361)3.79939411
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77464884
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76730991
50rRNA processing (GO:0006364)3.74596329
51spindle checkpoint (GO:0031577)3.73497419
52blastocyst development (GO:0001824)3.70588055
53chaperone-mediated protein transport (GO:0072321)3.68476460
54mitotic spindle checkpoint (GO:0071174)3.67062570
55regulation of translation in response to stress (GO:0043555)3.66850224
56multicellular organismal water homeostasis (GO:0050891)3.65254496
57protein localization to kinetochore (GO:0034501)3.63208741
58rRNA metabolic process (GO:0016072)3.62881471
59negative regulation of epidermis development (GO:0045683)3.58857630
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57079614
61mitotic nuclear envelope disassembly (GO:0007077)3.55415405
62amino acid salvage (GO:0043102)3.54983578
63L-methionine salvage (GO:0071267)3.54983578
64L-methionine biosynthetic process (GO:0071265)3.54983578
65protein K6-linked ubiquitination (GO:0085020)3.54883457
66regulation of meiosis I (GO:0060631)3.53564737
67negative regulation of chromosome segregation (GO:0051985)3.53489602
68regulation of hair follicle development (GO:0051797)3.53385192
69rRNA methylation (GO:0031167)3.53355606
70glycine metabolic process (GO:0006544)3.53187341
71spliceosomal snRNP assembly (GO:0000387)3.53076056
72mitotic chromosome condensation (GO:0007076)3.52286620
73regulation of chromosome segregation (GO:0051983)3.50233914
74attachment of spindle microtubules to kinetochore (GO:0008608)3.50113838
75DNA replication initiation (GO:0006270)3.49875357
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48367934
77negative regulation of sister chromatid segregation (GO:0033046)3.48367934
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.48367934
79negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48367934
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.47761159
81mitotic spindle assembly checkpoint (GO:0007094)3.46636693
82ribosomal large subunit biogenesis (GO:0042273)3.42767930
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38694933
84establishment of chromosome localization (GO:0051303)3.38477792
85spindle assembly checkpoint (GO:0071173)3.38371352
86maturation of 5.8S rRNA (GO:0000460)3.38152795
87cell-substrate junction assembly (GO:0007044)3.36104717
88CENP-A containing nucleosome assembly (GO:0034080)3.31212044
89DNA-templated transcription, elongation (GO:0006354)3.31077665
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30847563
91nuclear envelope disassembly (GO:0051081)3.30321271
92membrane disassembly (GO:0030397)3.30321271
93transcription elongation from RNA polymerase II promoter (GO:0006368)3.28521327
94intermediate filament organization (GO:0045109)3.27374067
95positive regulation of ligase activity (GO:0051351)3.25148638
96establishment of protein localization to mitochondrial membrane (GO:0090151)3.23873506
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23771161
98epidermis development (GO:0008544)3.23683716
99negative regulation of translational initiation (GO:0045947)3.23567594
100protein localization to chromosome, centromeric region (GO:0071459)3.23276116
101positive regulation of viral transcription (GO:0050434)3.22757681
102regulation of nuclear cell cycle DNA replication (GO:0033262)3.22436399
103pantothenate metabolic process (GO:0015939)3.21754751
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18770720
105negative regulation of ligase activity (GO:0051352)3.18770720
106kinetochore assembly (GO:0051382)3.17785866
107histone-serine phosphorylation (GO:0035404)3.17383132
108guanosine-containing compound biosynthetic process (GO:1901070)3.16349190
109piRNA metabolic process (GO:0034587)3.15436585
110oocyte development (GO:0048599)3.15372785
111DNA replication-independent nucleosome assembly (GO:0006336)3.14480944
112DNA replication-independent nucleosome organization (GO:0034724)3.14480944
113chromatin remodeling at centromere (GO:0031055)3.13406200
114autophagic vacuole assembly (GO:0000045)3.12983593
115protein autoprocessing (GO:0016540)3.11454952
116regulation of sister chromatid segregation (GO:0033045)3.09200763
117regulation of mitotic sister chromatid separation (GO:0010965)3.09200763
118regulation of mitotic sister chromatid segregation (GO:0033047)3.09200763
119transcription-coupled nucleotide-excision repair (GO:0006283)3.08185930
120regulation of exit from mitosis (GO:0007096)3.08051305
121regulation of ubiquitin-protein transferase activity (GO:0051438)3.07682045
122water homeostasis (GO:0030104)3.06934448
123keratinocyte differentiation (GO:0030216)3.06061782
124methionine biosynthetic process (GO:0009086)3.04824322
125mitotic sister chromatid segregation (GO:0000070)3.04276546
126regulation of double-strand break repair via homologous recombination (GO:0010569)3.04227485
127inner cell mass cell proliferation (GO:0001833)3.03924736
128positive regulation of hair follicle development (GO:0051798)3.01956098
129positive regulation of hair cycle (GO:0042635)3.01956098
130mitochondrial RNA metabolic process (GO:0000959)2.98491678
131hair cycle (GO:0042633)2.96389858
132molting cycle (GO:0042303)2.96389858
133positive regulation of epidermis development (GO:0045684)2.95770484
134regulation of transforming growth factor beta2 production (GO:0032909)2.94754480
135gap junction assembly (GO:0016264)2.89689367
136regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.86946225
137ventricular cardiac muscle cell development (GO:0055015)2.86299871
138long-chain fatty acid biosynthetic process (GO:0042759)2.83787097
139polarized epithelial cell differentiation (GO:0030859)2.82675242
140transcription from mitochondrial promoter (GO:0006390)2.81705544
141regulation of mitochondrial translation (GO:0070129)2.80550128
142male meiosis I (GO:0007141)2.78284611
143regulation of acrosome reaction (GO:0060046)2.76653400
144multicellular organism reproduction (GO:0032504)2.76108173
145regulation of hair cycle (GO:0042634)2.74546584
146regulation of spindle checkpoint (GO:0090231)2.70780019
147regulation of gene silencing by miRNA (GO:0060964)2.68354128
148regulation of gene silencing by RNA (GO:0060966)2.68354128
149regulation of posttranscriptional gene silencing (GO:0060147)2.68354128
150cellular protein complex localization (GO:0034629)2.67412525
151regulation of cardioblast differentiation (GO:0051890)2.67296091
152meiotic cell cycle (GO:0051321)2.65773060
153morphogenesis of embryonic epithelium (GO:0016331)2.64075639
154intermediate filament cytoskeleton organization (GO:0045104)2.64026368
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63082291
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63082291
157morphogenesis of an epithelial fold (GO:0060571)2.62036697
158ectoderm development (GO:0007398)2.61159296
159protein complex localization (GO:0031503)2.60026568
160positive regulation of epidermal cell differentiation (GO:0045606)2.59171223
161regulation of epidermis development (GO:0045682)2.59143484
162histone exchange (GO:0043486)2.56400819
163negative regulation of epidermal cell differentiation (GO:0045605)2.56228708
164protein targeting to mitochondrion (GO:0006626)2.55769590
165intermediate filament-based process (GO:0045103)2.50552856
166L-serine metabolic process (GO:0006563)2.50195504
167meiosis I (GO:0007127)2.48856236
168establishment of tissue polarity (GO:0007164)2.48425653
169establishment of planar polarity (GO:0001736)2.48425653
170epidermal cell differentiation (GO:0009913)2.48409500
171pyrimidine nucleoside salvage (GO:0043097)2.47363979
172pyrimidine-containing compound salvage (GO:0008655)2.47363979
173nucleoside salvage (GO:0043174)2.45432961
174female gamete generation (GO:0007292)2.45311303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.29509059
2E2F7_22180533_ChIP-Seq_HELA_Human5.69908276
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.23035189
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.05414015
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.65962603
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56302890
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49494592
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49087034
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.47151391
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35682711
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27277972
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.11577115
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.06014498
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91253868
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90710415
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.89849556
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86231150
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84837022
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82206680
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74944366
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61321032
22AR_21909140_ChIP-Seq_LNCAP_Human2.45941240
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.35003218
24VDR_23849224_ChIP-Seq_CD4+_Human2.34662326
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24623116
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17939859
27XRN2_22483619_ChIP-Seq_HELA_Human2.16029033
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.12297810
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10152833
30ZNF263_19887448_ChIP-Seq_K562_Human2.04077796
31GABP_19822575_ChIP-Seq_HepG2_Human2.02967074
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97348643
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96105336
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94830602
35DCP1A_22483619_ChIP-Seq_HELA_Human1.88230440
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.86057020
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84415151
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78183492
39FOXP3_21729870_ChIP-Seq_TREG_Human1.77454986
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75435016
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74059000
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68208713
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67332815
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.63540324
45KDM5A_27292631_Chip-Seq_BREAST_Human1.61223537
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58817653
47EZH2_22144423_ChIP-Seq_EOC_Human1.58630684
48TTF2_22483619_ChIP-Seq_HELA_Human1.57855212
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.53655817
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52283124
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51152300
52* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49776760
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49419894
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42893057
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42563100
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42563100
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42563100
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39849498
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37713708
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.34545758
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34244059
62ATF3_27146783_Chip-Seq_COLON_Human1.31195687
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28886701
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28886701
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27034764
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25888898
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25871761
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24334399
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.22727152
70ELK1_19687146_ChIP-ChIP_HELA_Human1.21089493
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20896472
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.20443047
73CIITA_25753668_ChIP-Seq_RAJI_Human1.20368285
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20225472
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.20029192
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18166762
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15609544
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15209415
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.15173347
80* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15125172
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14187248
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10972477
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10682431
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10099057
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09834813
86* TP63_22573176_ChIP-Seq_HFKS_Human1.08922927
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07819800
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06315287
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06124082
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04783957
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04409961
92* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04249598
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04043996
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.03804921
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03054600
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02602002
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01672925
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01626729
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01498271
100* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00786870
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.00060724
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99275525
103P68_20966046_ChIP-Seq_HELA_Human0.98561213
104* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97769251
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96785252
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96721672
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95289354
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.94092927
109* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93921205
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93614932
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92930889
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92581058
113TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91884918
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91176024
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90534379
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90491059
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90313504
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89970105
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89263576
120SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89217768
121RACK7_27058665_Chip-Seq_MCF-7_Human0.88853336
122* KAP1_27257070_Chip-Seq_ESCs_Mouse0.88583887
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88570555
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88484507
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88032807
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87624210
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86790976
128* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85478472
129* SMC4_20622854_ChIP-Seq_HELA_Human0.81714011
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.80875430
131PHF8_20622854_ChIP-Seq_HELA_Human0.80465397
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80356423
133* CTCF_20526341_ChIP-Seq_ESCs_Human0.80323210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.68461516
2MP0000579_abnormal_nail_morphology5.87536988
3MP0003111_abnormal_nucleus_morphology5.18383709
4MP0004957_abnormal_blastocyst_morpholog4.56283659
5MP0003718_maternal_effect4.50843511
6MP0002796_impaired_skin_barrier4.26208053
7MP0010234_abnormal_vibrissa_follicle4.07205666
8MP0010094_abnormal_chromosome_stability4.01428445
9MP0008260_abnormal_autophagy3.84003214
10MP0003077_abnormal_cell_cycle3.74047982
11MP0000566_synostosis3.51488117
12MP0008057_abnormal_DNA_replication3.20781439
13MP0000762_abnormal_tongue_morphology3.11775747
14MP0003123_paternal_imprinting3.11654144
15MP0005501_abnormal_skin_physiology3.01281044
16MP0008058_abnormal_DNA_repair2.98587003
17MP0000467_abnormal_esophagus_morphology2.88171900
18MP0003786_premature_aging2.85117840
19MP0002234_abnormal_pharynx_morphology2.64417657
20MP0001730_embryonic_growth_arrest2.55241247
21MP0008932_abnormal_embryonic_tissue2.52984916
22MP0009840_abnormal_foam_cell2.50601758
23MP0001216_abnormal_epidermal_layer2.29936481
24MP0003453_abnormal_keratinocyte_physiol2.17078593
25MP0002098_abnormal_vibrissa_morphology2.10531857
26MP0008007_abnormal_cellular_replicative2.09968276
27MP0010678_abnormal_skin_adnexa2.05575811
28MP0000350_abnormal_cell_proliferation2.04686632
29MP0005380_embryogenesis_phenotype2.02674825
30MP0001672_abnormal_embryogenesis/_devel2.02674825
31MP0008789_abnormal_olfactory_epithelium2.02491465
32MP0003878_abnormal_ear_physiology1.93970059
33MP0005377_hearing/vestibular/ear_phenot1.93970059
34MP0000678_abnormal_parathyroid_gland1.92443460
35MP0010771_integument_phenotype1.89844344
36MP0002060_abnormal_skin_morphology1.88952861
37MP0009379_abnormal_foot_pigmentation1.87798250
38MP0008877_abnormal_DNA_methylation1.80730456
39MP0005499_abnormal_olfactory_system1.80250161
40MP0005394_taste/olfaction_phenotype1.80250161
41MP0005451_abnormal_body_composition1.74967244
42MP0010307_abnormal_tumor_latency1.74659587
43MP0003984_embryonic_growth_retardation1.72249360
44MP0003566_abnormal_cell_adhesion1.70037955
45MP0001661_extended_life_span1.69551490
46MP0002088_abnormal_embryonic_growth/wei1.68376719
47MP0005395_other_phenotype1.67574547
48MP0001697_abnormal_embryo_size1.66530774
49MP0009053_abnormal_anal_canal1.64214257
50MP0003705_abnormal_hypodermis_morpholog1.64042115
51MP0005423_abnormal_somatic_nervous1.63204343
52MP0005409_darkened_coat_color1.62412589
53MP0002080_prenatal_lethality1.60506438
54MP0001542_abnormal_bone_strength1.57668426
55MP0004381_abnormal_hair_follicle1.55682984
56MP0003567_abnormal_fetal_cardiomyocyte1.54917990
57MP0000377_abnormal_hair_follicle1.53657106
58MP0005275_abnormal_skin_tensile1.48725913
59MP0002396_abnormal_hematopoietic_system1.44928593
60MP0002085_abnormal_embryonic_tissue1.43261982
61MP0002210_abnormal_sex_determination1.43249625
62MP0003315_abnormal_perineum_morphology1.42624715
63MP0003941_abnormal_skin_development1.41294944
64MP0003221_abnormal_cardiomyocyte_apopto1.41187752
65MP0009333_abnormal_splenocyte_physiolog1.41035457
66MP0003938_abnormal_ear_development1.39093214
67MP0002086_abnormal_extraembryonic_tissu1.30889697
68MP0001986_abnormal_taste_sensitivity1.30787705
69MP0001145_abnormal_male_reproductive1.29387848
70MP0002653_abnormal_ependyma_morphology1.28795834
71MP0002084_abnormal_developmental_patter1.22578304
72MP0001929_abnormal_gametogenesis1.19677429
73MP0000537_abnormal_urethra_morphology1.18407473
74MP0009672_abnormal_birth_weight1.15147201
75MP0000653_abnormal_sex_gland1.14714013
76MP0003755_abnormal_palate_morphology1.14336159
77MP0005023_abnormal_wound_healing1.11616506
78MP0000313_abnormal_cell_death1.11072651
79MP0003890_abnormal_embryonic-extraembry1.07137284
80MP0005397_hematopoietic_system_phenotyp1.05687781
81MP0001545_abnormal_hematopoietic_system1.05687781
82MP0003136_yellow_coat_color1.04633053
83MP0005360_urolithiasis1.02883878
84MP0004084_abnormal_cardiac_muscle1.01619133
85MP0004019_abnormal_vitamin_homeostasis0.99662232
86MP0001293_anophthalmia0.99555900
87MP0000427_abnormal_hair_cycle0.99375764
88MP0000358_abnormal_cell_content/0.98830316
89MP0002233_abnormal_nose_morphology0.96996285
90MP0009931_abnormal_skin_appearance0.94392724
91MP0003119_abnormal_digestive_system0.93236810
92MP0006035_abnormal_mitochondrial_morpho0.91453061
93MP0004197_abnormal_fetal_growth/weight/0.90847400
94MP0002102_abnormal_ear_morphology0.90089722
95MP0003937_abnormal_limbs/digits/tail_de0.89014524
96MP0005389_reproductive_system_phenotype0.87881949
97MP0006292_abnormal_olfactory_placode0.87857184
98MP0000627_abnormal_mammary_gland0.87253202
99MP0003806_abnormal_nucleotide_metabolis0.86552246
100MP0005621_abnormal_cell_physiology0.86334299
101MP0003699_abnormal_female_reproductive0.84461572
102MP0002019_abnormal_tumor_incidence0.84164531
103MP0005384_cellular_phenotype0.84019690
104MP0009703_decreased_birth_body0.83552692
105MP0002132_abnormal_respiratory_system0.83536504
106MP0000647_abnormal_sebaceous_gland0.82777379
107MP0002160_abnormal_reproductive_system0.82451562
108MP0000428_abnormal_craniofacial_morphol0.81863796
109MP0001756_abnormal_urination0.81167890
110MP0002697_abnormal_eye_size0.80052803
111MP0002127_abnormal_cardiovascular_syste0.78709598
112MP0004885_abnormal_endolymph0.77390142
113MP0002092_abnormal_eye_morphology0.76738727
114MP0000490_abnormal_crypts_of0.76555023
115MP0000747_muscle_weakness0.75354572
116MP0002177_abnormal_outer_ear0.74830136
117MP0001119_abnormal_female_reproductive0.73099238
118MP0001340_abnormal_eyelid_morphology0.73081636
119MP0002163_abnormal_gland_morphology0.72667243
120MP0002161_abnormal_fertility/fecundity0.72580418
121MP0001764_abnormal_homeostasis0.72366509
122MP0003936_abnormal_reproductive_system0.70796695
123MP0001188_hyperpigmentation0.69696634
124MP0000049_abnormal_middle_ear0.67935219
125MP0004270_analgesia0.66898220
126MP0010352_gastrointestinal_tract_polyps0.66401294
127MP0002095_abnormal_skin_pigmentation0.65476280
128MP0010368_abnormal_lymphatic_system0.65446994
129MP0003935_abnormal_craniofacial_develop0.65270599
130MP0003698_abnormal_male_reproductive0.64870655
131MP0002089_abnormal_postnatal_growth/wei0.64238664
132MP0000367_abnormal_coat/_hair0.64056620
133MP0005332_abnormal_amino_acid0.63620312
134MP0006036_abnormal_mitochondrial_physio0.63471061
135MP0002269_muscular_atrophy0.63459689
136MP0000383_abnormal_hair_follicle0.63147920
137MP0003186_abnormal_redox_activity0.62486546
138MP0001849_ear_inflammation0.60970904
139MP0002111_abnormal_tail_morphology0.60004033
140MP0000462_abnormal_digestive_system0.59677400
141MP0002736_abnormal_nociception_after0.59421300
142MP0004233_abnormal_muscle_weight0.58102210
143MP0001919_abnormal_reproductive_system0.57616262
144MP0010030_abnormal_orbit_morphology0.56422784
145MP0003121_genomic_imprinting0.56273997
146MP0003879_abnormal_hair_cell0.54654243
147MP0004264_abnormal_extraembryonic_tissu0.53911494
148MP0006138_congestive_heart_failure0.51812622
149MP0000516_abnormal_urinary_system0.51765089
150MP0005367_renal/urinary_system_phenotyp0.51765089

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)6.91608381
2Fragile nails (HP:0001808)6.36067456
3Plantar hyperkeratosis (HP:0007556)6.13506423
4Milia (HP:0001056)6.08951260
5Breast hypoplasia (HP:0003187)5.87683415
6Onycholysis (HP:0001806)5.74234926
7Birth length less than 3rd percentile (HP:0003561)5.74111319
8Hyperglycinemia (HP:0002154)5.58351393
9Palmoplantar hyperkeratosis (HP:0000972)5.17437485
10Impulsivity (HP:0100710)5.11188552
11Thick nail (HP:0001805)5.05449543
12Palmar hyperkeratosis (HP:0010765)4.92343089
13Cerebral hypomyelination (HP:0006808)4.81260809
14Alopecia of scalp (HP:0002293)4.75371342
15Carpal bone hypoplasia (HP:0001498)4.58728911
16Rough bone trabeculation (HP:0100670)4.53176607
17Hyperglycinuria (HP:0003108)4.49927105
18Nail dystrophy (HP:0008404)4.24728766
19Pili torti (HP:0003777)4.23676176
20Ureteral duplication (HP:0000073)3.90737450
21Lip pit (HP:0100267)3.89814319
22Aplasia/Hypoplasia of the patella (HP:0006498)3.81116793
23Patellar aplasia (HP:0006443)3.78200186
24Abnormality of glycine metabolism (HP:0010895)3.66334016
25Abnormality of serine family amino acid metabolism (HP:0010894)3.66334016
26Abnormality of the umbilical cord (HP:0010881)3.66294118
27Congenital ichthyosiform erythroderma (HP:0007431)3.63546180
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.59739581
29Abnormal hair laboratory examination (HP:0003328)3.47858500
30Right ventricular cardiomyopathy (HP:0011663)3.42587266
31Hypotrichosis (HP:0001006)3.42198833
32Ridged nail (HP:0001807)3.40303920
33Abnormality of the labia minora (HP:0012880)3.37130029
34Gout (HP:0001997)3.37023067
35Abnormality of the salivary glands (HP:0010286)3.35461285
36Atrophic scars (HP:0001075)3.34565275
37Abnormal trabecular bone morphology (HP:0100671)3.33242547
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31341239
39Premature ovarian failure (HP:0008209)3.31263200
40Entropion (HP:0000621)3.31125115
41Sparse scalp hair (HP:0002209)3.23128642
42Degeneration of anterior horn cells (HP:0002398)3.14624585
43Abnormality of the anterior horn cell (HP:0006802)3.14624585
44Abnormal blistering of the skin (HP:0008066)3.12703187
45Secondary amenorrhea (HP:0000869)3.09619531
46Absent radius (HP:0003974)3.08721154
47Abnormality of serum amino acid levels (HP:0003112)3.07865656
48Multiple enchondromatosis (HP:0005701)3.06322224
49Abnormality of placental membranes (HP:0011409)3.04267634
50Amniotic constriction ring (HP:0009775)3.04267634
51Muscle fiber splitting (HP:0003555)3.03559243
52Progressive muscle weakness (HP:0003323)2.91970370
53CNS hypomyelination (HP:0003429)2.90661731
54Absent forearm bone (HP:0003953)2.89549959
55Aplasia involving forearm bones (HP:0009822)2.89549959
56Death in infancy (HP:0001522)2.88793820
57Hypoplastic labia majora (HP:0000059)2.83754013
58Areflexia of lower limbs (HP:0002522)2.81888573
59Oligodactyly (hands) (HP:0001180)2.77104401
60Pterygium (HP:0001059)2.76950136
61Dry hair (HP:0011359)2.73755889
62Popliteal pterygium (HP:0009756)2.71916419
63Atrioventricular block (HP:0001678)2.71197168
64Oral leukoplakia (HP:0002745)2.67733695
65Bundle branch block (HP:0011710)2.64262123
66Abnormality of the distal phalanges of the toes (HP:0010182)2.63656982
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.61565360
68Oligodactyly (HP:0012165)2.60840506
69Abnormality of the labia majora (HP:0012881)2.59732287
70Sparse eyelashes (HP:0000653)2.56368380
71Pustule (HP:0200039)2.55773249
72Ventricular fibrillation (HP:0001663)2.55266811
73Tetraplegia (HP:0002445)2.52085810
74Aplasia/hypoplasia of the uterus (HP:0008684)2.51275613
75Absent eyelashes (HP:0000561)2.51057964
76Hypoplasia of the uterus (HP:0000013)2.50025100
77Erythroderma (HP:0001019)2.48435054
78Delusions (HP:0000746)2.47343482
79Abnormality of alanine metabolism (HP:0010916)2.45344638
80Hyperalaninemia (HP:0003348)2.45344638
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45344638
82Sparse lateral eyebrow (HP:0005338)2.43065509
83Megaloblastic anemia (HP:0001889)2.42625760
84Patent foramen ovale (HP:0001655)2.41259961
85Personality changes (HP:0000751)2.40337970
86Microretrognathia (HP:0000308)2.39900735
87Congenital, generalized hypertrichosis (HP:0004540)2.38100332
88Corneal erosion (HP:0200020)2.36820720
89Pelvic girdle muscle weakness (HP:0003749)2.34597860
90Trismus (HP:0000211)2.34459819
91Spinal muscular atrophy (HP:0007269)2.32476265
92Abnormalities of placenta or umbilical cord (HP:0001194)2.32015533
93Palmoplantar keratoderma (HP:0000982)2.29327073
94Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29129443
95Woolly hair (HP:0002224)2.29128856
96Premature rupture of membranes (HP:0001788)2.28206360
97Horseshoe kidney (HP:0000085)2.28192105
98Natal tooth (HP:0000695)2.27822453
99Abnormality of the renal collecting system (HP:0004742)2.25605606
100Duplicated collecting system (HP:0000081)2.24621805
101Anonychia (HP:0001798)2.24433949
102Oligodontia (HP:0000677)2.23715844
103Poikiloderma (HP:0001029)2.22968981
104Short nail (HP:0001799)2.22640545
105Abnormality of the preputium (HP:0100587)2.21838144
106Split foot (HP:0001839)2.21812142
107Shoulder girdle muscle weakness (HP:0003547)2.20907546
108Nasolacrimal duct obstruction (HP:0000579)2.20023351
109Dysautonomia (HP:0002459)2.19336861
110Facial hemangioma (HP:0000329)2.18718488
111Breast aplasia (HP:0100783)2.18158124
112Stillbirth (HP:0003826)2.17993118
113Meckel diverticulum (HP:0002245)2.16479274
114Squamous cell carcinoma (HP:0002860)2.14932257
115Restlessness (HP:0000711)2.13163653
116Hypoplasia of dental enamel (HP:0006297)2.12879526
117Abnormal spermatogenesis (HP:0008669)2.11133067
118Aplasia/Hypoplasia of the breasts (HP:0010311)2.10500080
119Selective tooth agenesis (HP:0001592)2.09547375
120Ankyloglossia (HP:0010296)2.09211511
121Irregular epiphyses (HP:0010582)2.08888497
122Atrophy/Degeneration involving motor neurons (HP:0007373)2.07737103
123Prolonged neonatal jaundice (HP:0006579)2.06812106
124Absent hand (HP:0004050)2.06624882
125Aplasia cutis congenita (HP:0001057)2.05095092
126Aplasia/hypoplasia of the humerus (HP:0006507)2.04635969
127Male infertility (HP:0003251)2.04321640
128Difficulty climbing stairs (HP:0003551)2.03744748
129Facial cleft (HP:0002006)2.03474857
130Brittle hair (HP:0002299)2.03216196
131Hyperglycemia (HP:0003074)2.02282190
132Hypohidrosis (HP:0000966)2.01120247
133Abnormality of the neuromuscular junction (HP:0003398)1.99528732
134Fatigable weakness (HP:0003473)1.99528732
135Hypoplastic female external genitalia (HP:0012815)1.99125262
136Parakeratosis (HP:0001036)1.98741695
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98558325
138Abnormality of the ileum (HP:0001549)1.96377166
139Ectropion (HP:0000656)1.96009629
140Labial hypoplasia (HP:0000066)1.95876723
141Glucose intolerance (HP:0000833)1.94924539
142Cleft eyelid (HP:0000625)1.94823175
143Carious teeth (HP:0000670)1.94654212
144Abnormality of secondary sexual hair (HP:0009888)1.94579149
145Abnormality of the axillary hair (HP:0100134)1.94579149
146Abnormality of the proximal phalanges of the hand (HP:0009834)1.94188004
147Osteolytic defects of the hand bones (HP:0009699)1.93512752
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.93512752
149Hypokinesia (HP:0002375)1.93272850
150Abnormality of the musculature of the pelvis (HP:0001469)1.92645536
151Abnormality of the hip-girdle musculature (HP:0001445)1.92645536
152Single umbilical artery (HP:0001195)1.92133853
153Abnormality of the fetal cardiovascular system (HP:0010948)1.92133853
154Abnormal umbilical cord blood vessels (HP:0011403)1.92133853
155Macrocytic anemia (HP:0001972)1.91796408
156Reduced subcutaneous adipose tissue (HP:0003758)1.91762888
157Bone marrow hypocellularity (HP:0005528)1.91331943
158Segmental peripheral demyelination/remyelination (HP:0003481)1.89548530
159Median cleft lip (HP:0000161)1.89379608
160Adrenal hypoplasia (HP:0000835)1.89175447
161Neoplasm of the pancreas (HP:0002894)1.89048730
162Erythema (HP:0010783)1.88562794
163Stenosis of the external auditory canal (HP:0000402)1.86527368
164Abnormality of the labia (HP:0000058)1.81791765
165Advanced eruption of teeth (HP:0006288)1.78804862
166Multifactorial inheritance (HP:0001426)1.76734898
167Absent hair (HP:0002298)1.76383880
168Microvesicular hepatic steatosis (HP:0001414)1.74900969
169Abnormality of the lacrimal duct (HP:0011481)1.73595838
170Hydroureter (HP:0000072)1.71413859
171Taurodontia (HP:0000679)1.70804537
172Abnormality of permanent molar morphology (HP:0011071)1.70804537
173Abnormality of the dental root (HP:0006486)1.70804537
174Blepharitis (HP:0000498)1.69670065
175Chromsome breakage (HP:0040012)1.68006472
176Abnormality of abdominal situs (HP:0011620)1.62418153
177Abdominal situs inversus (HP:0003363)1.62418153
178Fused cervical vertebrae (HP:0002949)1.62108383
179Skin pits (HP:0100276)1.57991747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.59611413
2WEE14.98652393
3PBK4.25084939
4AKT33.49905130
5TSSK63.26429917
6PLK43.24905638
7NEK23.04685921
8EIF2AK12.99898008
9MET2.98962556
10MST1R2.75459340
11STK162.46511680
12EPHA22.43751008
13BRSK22.37862663
14NME22.37069162
15MKNK22.24461191
16TTK2.20282444
17SRPK12.18112383
18EPHB22.15039047
19PLK32.12984850
20PLK12.11093077
21PNCK2.08228002
22NEK11.96746020
23DYRK31.92652490
24LMTK21.83494234
25PTK21.80576590
26EIF2AK31.74249675
27ACVR1B1.71140694
28MKNK11.70214776
29BRSK11.68033192
30PINK11.66491531
31PDK31.63348773
32PDK41.63348773
33CCNB11.55787604
34ZAK1.52522775
35MAP3K121.46284225
36VRK21.45869963
37PDK21.45734954
38FLT31.44348163
39MST41.43104199
40KSR21.41795384
41CDK91.41380317
42CDK191.40854072
43NTRK11.39273363
44CHEK21.36254005
45MAP3K21.36096466
46ARAF1.34097081
47AURKB1.32817827
48SMG11.30356142
49CDC71.29374756
50BRAF1.28753396
51STK31.21712125
52TESK11.21039127
53ALK1.20487236
54AURKA1.19816306
55TGFBR11.13143165
56CDK71.07963675
57LATS21.07457255
58STK38L1.05428940
59BMX1.02316508
60RPS6KA40.96924075
61PIM20.90920217
62CDK40.90822453
63MAP3K80.89331136
64TESK20.88084465
65CHEK10.85536971
66PRKCI0.79578736
67VRK10.75968147
68ATR0.74003392
69EIF2AK20.72164701
70TRIM280.71367076
71CDK20.67555112
72CSNK1G30.67522911
73PAK10.66283831
74IRAK30.65695063
75NME10.61133937
76KSR10.61053519
77STK240.60113997
78CSNK1E0.59619171
79CSNK2A20.57515023
80CSNK1G10.57203908
81PIM10.56458740
82CSNK2A10.56078011
83CAMK2G0.56025321
84MELK0.53170373
85MAP3K130.52138677
86CSNK1A1L0.50408935
87CDK10.48391560
88BCKDK0.47317240
89DYRK20.46264090
90STK40.44763769
91LATS10.44254578
92NUAK10.43114199
93EPHB10.41619382
94FER0.41530330
95ATM0.41451113
96RPS6KB20.41378786
97CDK30.41201096
98RPS6KA10.40856772
99PRKD30.40276219
100MAP2K20.39225923
101MAP3K60.36951506
102MAP3K90.36384026
103PRKAA10.36160631
104WNK30.36146789
105RIPK10.35983653
106MOS0.35922238
107CSNK1G20.35557923
108MAPKAPK30.34458893
109TLK10.33907586
110PHKG20.33023035
111PHKG10.33023035
112MTOR0.33007647
113CAMK2B0.32515371
114FGR0.32329499
115RPS6KA50.32318686
116AKT20.31875784
117MAP2K70.31374276
118ERBB40.31297048
119CSNK1A10.30825688
120PRKCG0.30262645
121STK100.29599880
122MAP3K10.29138027
123NTRK30.27095841
124PAK40.26996019
125NTRK20.26671589
126STK380.26604061
127MARK30.25292129
128RAF10.25152564
129CDK11A0.25092932
130MAP3K30.24084304
131ABL20.22434631
132CDK60.22135988
133MAP3K50.18586671
134CAMKK20.14163763
135PRKDC0.12405510
136MAPK100.12270013
137GSK3B0.10793090
138MAPK90.10356248
139NEK60.09200629
140CDK120.08462286
141TAOK10.06447424

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.53453680
2RNA polymerase_Homo sapiens_hsa030204.80593409
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.66189209
4Proteasome_Homo sapiens_hsa030503.70546981
5RNA transport_Homo sapiens_hsa030133.49804828
6DNA replication_Homo sapiens_hsa030302.94050170
7Spliceosome_Homo sapiens_hsa030402.65772275
8Pyrimidine metabolism_Homo sapiens_hsa002402.65364626
9Cell cycle_Homo sapiens_hsa041102.50322651
10Mismatch repair_Homo sapiens_hsa034302.39842066
11Regulation of autophagy_Homo sapiens_hsa041402.36964376
12Basal transcription factors_Homo sapiens_hsa030222.19173402
13Ribosome_Homo sapiens_hsa030102.18949343
14Folate biosynthesis_Homo sapiens_hsa007902.15284656
15Nucleotide excision repair_Homo sapiens_hsa034202.10742295
16Homologous recombination_Homo sapiens_hsa034402.04266457
17Base excision repair_Homo sapiens_hsa034102.03951728
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96954662
19Fatty acid elongation_Homo sapiens_hsa000621.91169722
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80626995
21Purine metabolism_Homo sapiens_hsa002301.72525595
22p53 signaling pathway_Homo sapiens_hsa041151.67013194
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59174878
24Oxidative phosphorylation_Homo sapiens_hsa001901.54849251
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51563828
26Fanconi anemia pathway_Homo sapiens_hsa034601.51541931
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.50700913
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47496296
29Steroid biosynthesis_Homo sapiens_hsa001001.46822000
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.42088357
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41842213
32Pentose phosphate pathway_Homo sapiens_hsa000301.38726199
33Oocyte meiosis_Homo sapiens_hsa041141.38280741
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.37480895
35Vitamin digestion and absorption_Homo sapiens_hsa049771.36634918
36Parkinsons disease_Homo sapiens_hsa050121.30516939
37mRNA surveillance pathway_Homo sapiens_hsa030151.29056020
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26741805
39RNA degradation_Homo sapiens_hsa030181.22769231
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22089966
41Epstein-Barr virus infection_Homo sapiens_hsa051691.21709749
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19580185
43One carbon pool by folate_Homo sapiens_hsa006701.19504302
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14984232
45Arginine biosynthesis_Homo sapiens_hsa002201.11290652
46Synaptic vesicle cycle_Homo sapiens_hsa047211.05608499
47Biosynthesis of amino acids_Homo sapiens_hsa012301.03888440
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03796787
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98834889
50Fructose and mannose metabolism_Homo sapiens_hsa000510.93995053
51Alzheimers disease_Homo sapiens_hsa050100.91449556
52Collecting duct acid secretion_Homo sapiens_hsa049660.91088543
53Sulfur relay system_Homo sapiens_hsa041220.90485793
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89818969
55Vibrio cholerae infection_Homo sapiens_hsa051100.88511844
56Adherens junction_Homo sapiens_hsa045200.84266951
57ECM-receptor interaction_Homo sapiens_hsa045120.81673712
58Cardiac muscle contraction_Homo sapiens_hsa042600.80736419
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80206020
60Phenylalanine metabolism_Homo sapiens_hsa003600.79821530
61Non-homologous end-joining_Homo sapiens_hsa034500.78638876
62Nicotine addiction_Homo sapiens_hsa050330.75916195
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74332188
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66899350
65Sulfur metabolism_Homo sapiens_hsa009200.64002381
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.61052381
67Circadian rhythm_Homo sapiens_hsa047100.60643077
68Selenocompound metabolism_Homo sapiens_hsa004500.59619590
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58509372
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55257653
71Carbon metabolism_Homo sapiens_hsa012000.52237554
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51492278
73Glutathione metabolism_Homo sapiens_hsa004800.49252715
74Wnt signaling pathway_Homo sapiens_hsa043100.49220026
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47094816
76mTOR signaling pathway_Homo sapiens_hsa041500.46260415
77Arginine and proline metabolism_Homo sapiens_hsa003300.46069996
78Metabolic pathways_Homo sapiens_hsa011000.45234173
79Basal cell carcinoma_Homo sapiens_hsa052170.45202644
80Antigen processing and presentation_Homo sapiens_hsa046120.44233548
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42759676
82Pyruvate metabolism_Homo sapiens_hsa006200.40470850
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40408835
84Axon guidance_Homo sapiens_hsa043600.40295469
85Taste transduction_Homo sapiens_hsa047420.40211294
86Bladder cancer_Homo sapiens_hsa052190.39842217
87Ovarian steroidogenesis_Homo sapiens_hsa049130.39815579
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38656476
89Protein export_Homo sapiens_hsa030600.38407508
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.38383062
91Gap junction_Homo sapiens_hsa045400.37788648
92ErbB signaling pathway_Homo sapiens_hsa040120.36600927
93Shigellosis_Homo sapiens_hsa051310.33719025
94Viral carcinogenesis_Homo sapiens_hsa052030.32950217
95N-Glycan biosynthesis_Homo sapiens_hsa005100.32290365
96Hippo signaling pathway_Homo sapiens_hsa043900.32084342
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30900719
98Herpes simplex infection_Homo sapiens_hsa051680.30145132
99FoxO signaling pathway_Homo sapiens_hsa040680.29868116
100GABAergic synapse_Homo sapiens_hsa047270.28503120
101Linoleic acid metabolism_Homo sapiens_hsa005910.27359846
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26895635
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26686410
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26435890
105Glycerolipid metabolism_Homo sapiens_hsa005610.24033041
106HTLV-I infection_Homo sapiens_hsa051660.20367542
107Arachidonic acid metabolism_Homo sapiens_hsa005900.19529154
108Hedgehog signaling pathway_Homo sapiens_hsa043400.18323329
109Renin-angiotensin system_Homo sapiens_hsa046140.17533748
110Mineral absorption_Homo sapiens_hsa049780.16722413
111Small cell lung cancer_Homo sapiens_hsa052220.15455763
112Lysosome_Homo sapiens_hsa041420.15282271
113Galactose metabolism_Homo sapiens_hsa000520.15137812
114Huntingtons disease_Homo sapiens_hsa050160.13777849
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12896093
116HIF-1 signaling pathway_Homo sapiens_hsa040660.12525571
117Inositol phosphate metabolism_Homo sapiens_hsa005620.11627783
118MicroRNAs in cancer_Homo sapiens_hsa052060.10663973
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10331656
120beta-Alanine metabolism_Homo sapiens_hsa004100.10222327
121Tight junction_Homo sapiens_hsa045300.08906514
122Sphingolipid metabolism_Homo sapiens_hsa006000.08775868
123Thyroid cancer_Homo sapiens_hsa052160.07356714
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05748210
125Retinol metabolism_Homo sapiens_hsa008300.05643149
126Butanoate metabolism_Homo sapiens_hsa006500.05009210
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.04993202
128Renal cell carcinoma_Homo sapiens_hsa052110.04278432
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03255745
130Systemic lupus erythematosus_Homo sapiens_hsa053220.01988499
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01692861
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01352254
133AMPK signaling pathway_Homo sapiens_hsa041520.01264473
134Prostate cancer_Homo sapiens_hsa052150.00775785
135Apoptosis_Homo sapiens_hsa042100.00416627
136Fat digestion and absorption_Homo sapiens_hsa04975-0.0453507
137Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0329181
138TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0202676
139Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0139082
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0051890
141NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0037482
142Prion diseases_Homo sapiens_hsa05020-0.0036780

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