SOX17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.47540806
2retina vasculature morphogenesis in camera-type eye (GO:0061299)7.61275484
3endothelium development (GO:0003158)6.85305074
4vascular endothelial growth factor signaling pathway (GO:0038084)6.20787075
5basement membrane organization (GO:0071711)6.16205250
6lymphangiogenesis (GO:0001946)5.62865613
7negative regulation of inclusion body assembly (GO:0090084)5.45839709
8angiogenesis involved in wound healing (GO:0060055)5.28852915
9regulation of cardioblast differentiation (GO:0051890)5.16189130
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.16058124
11patterning of blood vessels (GO:0001569)5.15498764
12endothelial tube morphogenesis (GO:0061154)5.10714090
13morphogenesis of an endothelium (GO:0003159)5.10714090
14surfactant homeostasis (GO:0043129)5.03171434
15positive regulation of urine volume (GO:0035810)4.99435053
16hemidesmosome assembly (GO:0031581)4.99032600
17polarized epithelial cell differentiation (GO:0030859)4.92347506
18positive regulation of vasculogenesis (GO:2001214)4.74285850
19regulation of endothelial cell differentiation (GO:0045601)4.70587031
20regulation of vasculogenesis (GO:2001212)4.50249373
21endothelial cell morphogenesis (GO:0001886)4.49046396
22establishment of apical/basal cell polarity (GO:0035089)4.40958205
23vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.37266619
24regulation of transforming growth factor beta1 production (GO:0032908)4.36892566
25ovulation from ovarian follicle (GO:0001542)4.32600775
26venous blood vessel morphogenesis (GO:0048845)4.29517278
27blood vessel maturation (GO:0001955)4.26124815
28blood vessel endothelial cell migration (GO:0043534)4.22221610
29cell migration involved in sprouting angiogenesis (GO:0002042)4.16507597
30renal filtration (GO:0097205)4.14844637
31regulation of blood vessel endothelial cell migration (GO:0043535)4.08509178
32heart trabecula formation (GO:0060347)4.03943964
33atrioventricular valve morphogenesis (GO:0003181)4.03878600
34* endothelial cell differentiation (GO:0045446)4.00164522
35coronary vasculature morphogenesis (GO:0060977)3.99195957
36* vasculogenesis (GO:0001570)3.98960758
37response to BMP (GO:0071772)3.98743993
38cellular response to BMP stimulus (GO:0071773)3.98743993
39* mRNA transcription from RNA polymerase II promoter (GO:0042789)3.96265570
40chemical homeostasis within a tissue (GO:0048875)3.89426303
41establishment of endothelial barrier (GO:0061028)3.87816189
42* embryonic foregut morphogenesis (GO:0048617)3.78786086
43glomerular filtration (GO:0003094)3.74887620
44establishment or maintenance of monopolar cell polarity (GO:0061339)3.63323890
45establishment of monopolar cell polarity (GO:0061162)3.63323890
46transcytosis (GO:0045056)3.59105606
47regulation of tight junction assembly (GO:2000810)3.53395271
48sprouting angiogenesis (GO:0002040)3.52755992
49artery development (GO:0060840)3.52202476
50lung vasculature development (GO:0060426)3.50689303
51regulation of urine volume (GO:0035809)3.48544487
52substrate adhesion-dependent cell spreading (GO:0034446)3.48452298
53cell migration involved in heart development (GO:0060973)3.48188507
54negative regulation of epithelial cell migration (GO:0010633)3.48034589
55blood vessel remodeling (GO:0001974)3.44376492
56regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.43816896
57positive regulation of endothelial cell differentiation (GO:0045603)3.40449816
58mesodermal cell differentiation (GO:0048333)3.36198696
59Notch signaling involved in heart development (GO:0061314)3.36136319
60blood vessel morphogenesis (GO:0048514)3.36096572
61positive regulation of odontogenesis (GO:0042482)3.35048593
62branching involved in salivary gland morphogenesis (GO:0060445)3.33537133
63ventricular trabecula myocardium morphogenesis (GO:0003222)3.31908994
64regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.31839913
65protein hydroxylation (GO:0018126)3.30750115
66endocardial cushion development (GO:0003197)3.30440280
67peptidyl-proline hydroxylation (GO:0019511)3.30375245
68cell proliferation involved in kidney development (GO:0072111)3.30335575
69SMAD protein signal transduction (GO:0060395)3.29729118
70cell-substrate junction assembly (GO:0007044)3.29486703
71peptidyl-tyrosine autophosphorylation (GO:0038083)3.28284467
72* endoderm formation (GO:0001706)3.26669833
73cardiac right ventricle morphogenesis (GO:0003215)3.25223241
74trabecula morphogenesis (GO:0061383)3.24743921
75regulation of inclusion body assembly (GO:0090083)3.21146607
76substrate-dependent cell migration (GO:0006929)3.20134212
77lung morphogenesis (GO:0060425)3.19291873
78positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.19133606
79regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.18861602
80* mRNA transcription (GO:0009299)3.17658455
814-hydroxyproline metabolic process (GO:0019471)3.16539658
82wound healing, spreading of epidermal cells (GO:0035313)3.16192035
83ventricular septum morphogenesis (GO:0060412)3.15198623
84protein refolding (GO:0042026)3.15061819
85positive regulation of renal sodium excretion (GO:0035815)3.13062503
86endochondral ossification (GO:0001958)3.12236377
87replacement ossification (GO:0036075)3.12236377
88negative regulation of angiogenesis (GO:0016525)3.11816397
89positive regulation of glomerulus development (GO:0090193)3.11111991
90Notch receptor processing (GO:0007220)3.11074213
91* embryonic heart tube development (GO:0035050)3.10467197
92establishment of epithelial cell polarity (GO:0090162)3.08772602
93* angiogenesis (GO:0001525)3.07757649
94hippo signaling (GO:0035329)3.07299593
95adherens junction assembly (GO:0034333)3.06559727
96endothelial cell migration (GO:0043542)3.05807290
97glomerular basement membrane development (GO:0032836)3.05675454
98heart trabecula morphogenesis (GO:0061384)3.05114518
99endothelial cell chemotaxis (GO:0035767)3.04852005
100wound healing, spreading of cells (GO:0044319)3.04426794
101cell surface receptor signaling pathway involved in heart development (GO:0061311)3.04176326
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03556694
103negative regulation of blood vessel endothelial cell migration (GO:0043537)3.01238147
104nephron epithelium development (GO:0072009)3.00076010
105negative regulation of blood vessel morphogenesis (GO:2000181)2.99682147
106regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97217145
107negative regulation of vasculature development (GO:1901343)2.97077511
108endothelial cell proliferation (GO:0001935)2.95957170
109regulation of hippo signaling (GO:0035330)2.94985987
110neural crest cell development (GO:0014032)2.94015082
111negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.91031583
112epithelial cell-cell adhesion (GO:0090136)2.91010250
113negative regulation of endothelial cell migration (GO:0010596)2.85866841
114positive regulation of metanephros development (GO:0072216)2.84395752
115cell proliferation involved in metanephros development (GO:0072203)2.83838888
116negative regulation of focal adhesion assembly (GO:0051895)2.83312243
117negative regulation of cell junction assembly (GO:1901889)2.83312243
118negative regulation of adherens junction organization (GO:1903392)2.83312243
119ventricular septum development (GO:0003281)2.83198329
120regulation of p38MAPK cascade (GO:1900744)2.82585374
121trabecula formation (GO:0060343)2.82014896
122negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.81984721
123regulation of cardiac muscle cell contraction (GO:0086004)2.81830453
124gap junction assembly (GO:0016264)2.79023482
125low-density lipoprotein particle clearance (GO:0034383)2.78853771
126cardiac ventricle morphogenesis (GO:0003208)2.78290174
127ear development (GO:0043583)2.77908327
128heart valve formation (GO:0003188)2.76770065
129negative regulation of vascular permeability (GO:0043116)2.76267424
130cardiac chamber morphogenesis (GO:0003206)2.75973793
131ventricular cardiac muscle cell development (GO:0055015)2.75388169
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74328103
133regulation of glomerular filtration (GO:0003093)2.72994108
134artery morphogenesis (GO:0048844)2.72436478
135positive regulation of astrocyte differentiation (GO:0048711)2.71689022
136positive regulation of endothelial cell proliferation (GO:0001938)2.71111389
137vasculature development (GO:0001944)2.70806763
138protein localization to endosome (GO:0036010)2.70601250
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69945930
140* cell migration involved in gastrulation (GO:0042074)2.69252966
141positive regulation of cartilage development (GO:0061036)2.69136042
142positive regulation of p38MAPK cascade (GO:1900745)2.68988087
143regulation of establishment or maintenance of cell polarity (GO:0032878)2.68202509
144negative regulation of Rho protein signal transduction (GO:0035024)2.66969527
145* negative regulation of cell fate specification (GO:0009996)2.66811391
146regulation of vascular permeability (GO:0043114)2.65365944
147regulation of actin filament-based movement (GO:1903115)2.64503060
148regulation of endothelial cell migration (GO:0010594)2.63969469
149morphogenesis of an epithelial sheet (GO:0002011)2.63849925
150cell adhesion mediated by integrin (GO:0033627)2.62830656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.22260440
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.51393768
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71951490
4CLOCK_20551151_ChIP-Seq_293T_Human3.68922136
5ZNF263_19887448_ChIP-Seq_K562_Human3.46663895
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.37810235
7* SALL4_18804426_ChIP-ChIP_XEN_Mouse3.27472639
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88152299
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.85150776
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79779499
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.76597124
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.68211525
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.65273788
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41682667
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40969090
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.34961101
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.34946801
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.31706536
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.19933980
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.11431300
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10141051
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09772015
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00864894
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.97707903
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97204905
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93305467
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93305467
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93305467
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93263695
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93263695
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88919525
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79498997
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75401226
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.75174808
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.75174808
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75111869
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.73363234
38* SMAD3_21741376_ChIP-Seq_HESCs_Human1.73288894
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71023855
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69434383
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68686762
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.64117885
43* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63667920
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.63011339
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62360706
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62273856
47AR_21909140_ChIP-Seq_LNCAP_Human1.61852408
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.61834987
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61060551
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59566246
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58634125
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57507917
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57066739
54SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51310876
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50767482
56* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46252143
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43657543
58GATA1_19941826_ChIP-Seq_K562_Human1.41346493
59* SMAD4_21741376_ChIP-Seq_HESCs_Human1.40230859
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39070339
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39070339
62RACK7_27058665_Chip-Seq_MCF-7_Human1.38686831
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37601004
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36453835
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35361309
66* EZH2_27304074_Chip-Seq_ESCs_Mouse1.34769650
67* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34334791
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30419271
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27735806
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.27088588
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.26957076
72* TP53_20018659_ChIP-ChIP_R1E_Mouse1.25765300
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25627434
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.25344674
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24553637
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23846471
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23545381
78KDM2B_26808549_Chip-Seq_K562_Human1.23455374
79SOX2_20726797_ChIP-Seq_SW620_Human1.23166412
80CJUN_26792858_Chip-Seq_BT549_Human1.22451153
81* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22317280
82ATF3_27146783_Chip-Seq_COLON_Human1.21005557
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20760662
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20744813
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20459517
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20416005
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19994622
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19341890
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18548278
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18316653
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17926445
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16401047
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14892789
94* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14691022
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14627792
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13975673
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13792163
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.13492751
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12696999
100* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12122743
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08457635
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07400204
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.07252861
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06708836
105* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06486684
106TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05718436
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.04480790
108LXR_22292898_ChIP-Seq_THP-1_Human1.03731949
109* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03025887
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.02973112
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02599028
112RXR_22158963_ChIP-Seq_LIVER_Mouse1.01393483
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00422974
114* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99271252
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99122062
116* GATA4_25053715_ChIP-Seq_YYC3_Human0.99079216
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98424254
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97403328
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96535984
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96463498
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94619059
122* RNF2_27304074_Chip-Seq_ESCs_Mouse0.94324015
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93679681
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93403797
125* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93162955
126NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92844218
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92763670
128AHR_22903824_ChIP-Seq_MCF-7_Human0.91447551
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90642366
130* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88807391
131* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84843362
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84310839
133NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82044430
134* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81127525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane6.80634389
2MP0010368_abnormal_lymphatic_system6.10509830
3MP0001879_abnormal_lymphatic_vessel4.91888720
4MP0005167_abnormal_blood-brain_barrier4.83935676
5MP0005623_abnormal_meninges_morphology4.28574455
6MP0004233_abnormal_muscle_weight2.94527790
7MP0003828_pulmonary_edema2.69379242
8MP0006138_congestive_heart_failure2.64869397
9MP0004084_abnormal_cardiac_muscle2.46642524
10MP0003705_abnormal_hypodermis_morpholog2.41642460
11MP0000465_gastrointestinal_hemorrhage2.40199470
12MP0006054_spinal_hemorrhage2.32420602
13MP0005409_darkened_coat_color2.29636932
14MP0010234_abnormal_vibrissa_follicle2.09123033
15MP0000537_abnormal_urethra_morphology2.08499291
16MP0001915_intracranial_hemorrhage1.89280458
17MP0002127_abnormal_cardiovascular_syste1.82627614
18MP0009384_cardiac_valve_regurgitation1.79017393
19MP0000767_abnormal_smooth_muscle1.77554667
20MP0003567_abnormal_fetal_cardiomyocyte1.75966875
21MP0003279_aneurysm1.69572857
22MP0009379_abnormal_foot_pigmentation1.67312382
23MP0004484_altered_response_of1.62296010
24MP0004215_abnormal_myocardial_fiber1.58478227
25MP0008004_abnormal_stomach_pH1.53963285
26MP0002925_abnormal_cardiovascular_devel1.50080806
27MP0005385_cardiovascular_system_phenoty1.43834280
28MP0001544_abnormal_cardiovascular_syste1.43834280
29MP0004036_abnormal_muscle_relaxation1.42747929
30MP0010630_abnormal_cardiac_muscle1.41700651
31MP0003566_abnormal_cell_adhesion1.40238086
32MP0005330_cardiomyopathy1.36928674
33MP0010030_abnormal_orbit_morphology1.35532260
34MP0004147_increased_porphyrin_level1.35222957
35MP0005165_increased_susceptibility_to1.33764130
36MP0004858_abnormal_nervous_system1.32379431
37MP0002128_abnormal_blood_circulation1.28627013
38MP0001614_abnormal_blood_vessel1.28554883
39MP0005164_abnormal_response_to1.27164229
40MP0003941_abnormal_skin_development1.26852605
41MP0003303_peritoneal_inflammation1.25078201
42MP0001958_emphysema1.24038600
43MP0003091_abnormal_cell_migration1.23291274
44* MP0002086_abnormal_extraembryonic_tissu1.22760490
45MP0004883_abnormal_blood_vessel1.21080235
46MP0004085_abnormal_heartbeat1.20880508
47MP0005670_abnormal_white_adipose1.18341297
48MP0002138_abnormal_hepatobiliary_system1.16580887
49MP0000249_abnormal_blood_vessel1.14998397
50MP0008775_abnormal_heart_ventricle1.14970872
51MP0003136_yellow_coat_color1.13540704
52MP0002254_reproductive_system_inflammat1.13536912
53MP0003950_abnormal_plasma_membrane1.12738238
54MP0002295_abnormal_pulmonary_circulatio1.12684378
55MP0003890_abnormal_embryonic-extraembry1.12278872
56MP0009278_abnormal_bone_marrow1.11428409
57MP0004133_heterotaxia1.11045583
58MP0001849_ear_inflammation1.10905860
59MP0003724_increased_susceptibility_to1.10468941
60MP0005595_abnormal_vascular_smooth1.10301361
61MP0002972_abnormal_cardiac_muscle1.08823678
62MP0003115_abnormal_respiratory_system1.07946925
63MP0008438_abnormal_cutaneous_collagen1.07778163
64MP0000733_abnormal_muscle_development1.07494481
65MP0000751_myopathy1.07490839
66* MP0003984_embryonic_growth_retardation1.03507549
67MP0000266_abnormal_heart_morphology1.02593672
68MP0002877_abnormal_melanocyte_morpholog1.02464375
69MP0002332_abnormal_exercise_endurance1.01824090
70* MP0002088_abnormal_embryonic_growth/wei1.01615926
71MP0001730_embryonic_growth_arrest1.00522930
72MP0005023_abnormal_wound_healing0.99407868
73* MP0003119_abnormal_digestive_system0.99314215
74MP0005620_abnormal_muscle_contractility0.99081893
75MP0002697_abnormal_eye_size0.97158582
76MP0000762_abnormal_tongue_morphology0.95122198
77MP0005187_abnormal_penis_morphology0.94474978
78MP0004087_abnormal_muscle_fiber0.93855675
79MP0001784_abnormal_fluid_regulation0.91790365
80MP0003935_abnormal_craniofacial_develop0.90915110
81* MP0001672_abnormal_embryogenesis/_devel0.89861575
82* MP0005380_embryogenesis_phenotype0.89861575
83MP0002932_abnormal_joint_morphology0.87688315
84MP0002277_abnormal_respiratory_mucosa0.85220821
85MP0000750_abnormal_muscle_regeneration0.83130446
86MP0000343_altered_response_to0.82043438
87* MP0002084_abnormal_developmental_patter0.81817298
88MP0003385_abnormal_body_wall0.81673300
89MP0005367_renal/urinary_system_phenotyp0.81439414
90MP0000516_abnormal_urinary_system0.81439414
91MP0009250_abnormal_appendicular_skeleto0.79706535
92MP0000534_abnormal_ureter_morphology0.79240366
93MP0000049_abnormal_middle_ear0.77544191
94MP0004197_abnormal_fetal_growth/weight/0.75587543
95MP0001697_abnormal_embryo_size0.75405388
96MP0003283_abnormal_digestive_organ0.75080674
97MP0000013_abnormal_adipose_tissue0.74810067
98MP0002249_abnormal_larynx_morphology0.74765370
99MP0000467_abnormal_esophagus_morphology0.74629531
100MP0002933_joint_inflammation0.73934307
101* MP0003943_abnormal_hepatobiliary_system0.71875798
102MP0005666_abnormal_adipose_tissue0.67049578
103MP0004145_abnormal_muscle_electrophysio0.66023873
104MP0003221_abnormal_cardiomyocyte_apopto0.65452269
105MP0002092_abnormal_eye_morphology0.65221629
106MP0002269_muscular_atrophy0.65023345
107MP0000003_abnormal_adipose_tissue0.64788978
108MP0002098_abnormal_vibrissa_morphology0.64531563
109MP0001175_abnormal_lung_morphology0.64481217
110MP0005275_abnormal_skin_tensile0.63996039
111MP0002108_abnormal_muscle_morphology0.63823027
112MP0004185_abnormal_adipocyte_glucose0.62776630
113MP0005360_urolithiasis0.61923127
114MP0002796_impaired_skin_barrier0.61212789
115MP0002896_abnormal_bone_mineralization0.61200640
116MP0004130_abnormal_muscle_cell0.61096969
117MP0002106_abnormal_muscle_physiology0.60384686
118MP0000749_muscle_degeneration0.59860775
119* MP0002085_abnormal_embryonic_tissue0.59746051
120MP0003937_abnormal_limbs/digits/tail_de0.59732708
121MP0001270_distended_abdomen0.59357416
122MP0005375_adipose_tissue_phenotype0.59327403
123MP0004782_abnormal_surfactant_physiolog0.58797803
124MP0005508_abnormal_skeleton_morphology0.58164304
125MP0000462_abnormal_digestive_system0.57728355
126MP0002233_abnormal_nose_morphology0.56412512
127MP0000759_abnormal_skeletal_muscle0.55938737
128MP0003638_abnormal_response/metabolism_0.55762215
129MP0001851_eye_inflammation0.55015039
130MP0003186_abnormal_redox_activity0.54978374
131MP0005197_abnormal_uvea_morphology0.54575426

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)5.25783116
2Polycythemia (HP:0001901)4.88387688
3Hypoplasia of the iris (HP:0007676)4.40685430
4Esophageal varix (HP:0002040)4.37614201
5Exercise-induced muscle cramps (HP:0003710)3.96729357
6Lymphangioma (HP:0100764)3.80910783
7Hemiplegia (HP:0002301)3.69636086
8Absent eyebrow (HP:0002223)3.65987075
9Fibular aplasia (HP:0002990)3.64191031
10Porencephaly (HP:0002132)3.51131898
11Annular pancreas (HP:0001734)3.48278799
12Split foot (HP:0001839)3.44350277
13Hematochezia (HP:0002573)3.40817848
14Muscle fiber splitting (HP:0003555)3.40022622
15Wrist flexion contracture (HP:0001239)3.34388469
16Hemorrhage of the eye (HP:0011885)3.26218217
17Absent hand (HP:0004050)3.12397586
18Vertebral clefting (HP:0008428)3.02719688
19Hypoplastic left heart (HP:0004383)3.00656663
20Congenital malformation of the right heart (HP:0011723)2.98663788
21Double outlet right ventricle (HP:0001719)2.98663788
22Increased connective tissue (HP:0009025)2.97544960
23Hypoglycemic coma (HP:0001325)2.93318004
24Bulbar palsy (HP:0001283)2.87470730
25Adactyly (HP:0009776)2.86043161
26Aneurysm (HP:0002617)2.74482967
27Deep venous thrombosis (HP:0002625)2.72882316
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72881061
29Amblyopia (HP:0000646)2.72573910
30Visceral angiomatosis (HP:0100761)2.70305353
31Skull defect (HP:0001362)2.68530491
32Type 2 muscle fiber atrophy (HP:0003554)2.68135782
33Vascular tortuosity (HP:0004948)2.62279648
34Spontaneous hematomas (HP:0007420)2.62228148
35Weak cry (HP:0001612)2.61735511
36Aplasia involving bones of the upper limbs (HP:0009823)2.61220918
37Aplasia of the phalanges of the hand (HP:0009802)2.61220918
38Aplasia involving bones of the extremities (HP:0009825)2.61220918
39Short hallux (HP:0010109)2.59587671
40Protrusio acetabuli (HP:0003179)2.58938752
41Arterial tortuosity (HP:0005116)2.58374478
42Esophageal atresia (HP:0002032)2.55400944
43Hemangiomatosis (HP:0007461)2.55308325
44Oligodactyly (hands) (HP:0001180)2.54144147
45Abnormality of the pubic bones (HP:0003172)2.53449401
46Ventricular tachycardia (HP:0004756)2.52699578
47Flat acetabular roof (HP:0003180)2.51735988
48Right ventricular cardiomyopathy (HP:0011663)2.48660304
49Intestinal atresia (HP:0011100)2.47672706
50Nonprogressive disorder (HP:0003680)2.47333568
51Polygenic inheritance (HP:0010982)2.46939093
52Shallow orbits (HP:0000586)2.45171081
53Mesangial abnormality (HP:0001966)2.45077721
54Sudden death (HP:0001699)2.44173021
55Aortic dissection (HP:0002647)2.40356883
56Abnormality of the ischium (HP:0003174)2.40027079
57Onycholysis (HP:0001806)2.39834498
58Tetraparesis (HP:0002273)2.38146099
59Distal lower limb muscle weakness (HP:0009053)2.36718838
60Spinal rigidity (HP:0003306)2.33299597
61Stenosis of the external auditory canal (HP:0000402)2.32092294
62Short humerus (HP:0005792)2.31860514
63Supraventricular arrhythmia (HP:0005115)2.31281777
64Aplasia/Hypoplasia of the hallux (HP:0008362)2.30954463
65Aortic aneurysm (HP:0004942)2.30669148
66Broad metatarsal (HP:0001783)2.29938716
67Premature rupture of membranes (HP:0001788)2.29096700
68Portal hypertension (HP:0001409)2.27106514
69Absent eyelashes (HP:0000561)2.26898166
70Venous insufficiency (HP:0005293)2.26875676
71Myotonia (HP:0002486)2.25095618
72Hyporeflexia of lower limbs (HP:0002600)2.22953002
73Cerebral hemorrhage (HP:0001342)2.21149111
74Abnormality of proline metabolism (HP:0010907)2.21066657
75Hydroxyprolinuria (HP:0003080)2.21066657
76Muscle fiber atrophy (HP:0100295)2.20574092
77Absent toe (HP:0010760)2.20477877
78Difficulty climbing stairs (HP:0003551)2.18831210
79Abnormality of the fetal cardiovascular system (HP:0010948)2.18430851
80Abnormal umbilical cord blood vessels (HP:0011403)2.18430851
81Single umbilical artery (HP:0001195)2.18430851
82Venous abnormality (HP:0002624)2.12998278
83Difficulty running (HP:0009046)2.12698174
84Congenital, generalized hypertrichosis (HP:0004540)2.12669583
85Aplasia/hypoplasia of the humerus (HP:0006507)2.11815071
86Shawl scrotum (HP:0000049)2.11323750
87Rectal prolapse (HP:0002035)2.09474106
88Gonadotropin excess (HP:0000837)2.08278378
89Hypoglycemic seizures (HP:0002173)2.06047296
90Retinal atrophy (HP:0001105)2.05429469
91Muscle stiffness (HP:0003552)2.04889380
92Hyperinsulinemic hypoglycemia (HP:0000825)2.04571832
93Hypoplastic heart (HP:0001961)2.03337511
94Periauricular skin pits (HP:0100277)2.03082898
95Preauricular pit (HP:0004467)2.03082898
96Cervical subluxation (HP:0003308)2.02938286
97Abnormality of the nasal mucosa (HP:0000433)2.02782197
98Aortic valve stenosis (HP:0001650)2.01961229
99Abnormality of the 2nd finger (HP:0004100)2.01878893
100Nonimmune hydrops fetalis (HP:0001790)2.01806596
101Abnormality of the 1st metacarpal (HP:0010009)2.01457159
102Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01112516
103Hemiparesis (HP:0001269)1.99363110
104Stroke (HP:0001297)1.98629684
105Hypotrichosis (HP:0001006)1.98382195
106Myoglobinuria (HP:0002913)1.98126859
107Abnormal ventriculo-arterial connection (HP:0011563)1.97682904
108Transposition of the great arteries (HP:0001669)1.97682904
109Abnormal connection of the cardiac segments (HP:0011545)1.97682904
110Anterior segment dysgenesis (HP:0007700)1.97654151
111Short phalanx of the thumb (HP:0009660)1.97472390
112Focal segmental glomerulosclerosis (HP:0000097)1.96967073
113Anal stenosis (HP:0002025)1.96272276
114Abnormal pancreas size (HP:0012094)1.96083825
115Pancreatic islet-cell hyperplasia (HP:0004510)1.95419747
116Anteriorly placed anus (HP:0001545)1.94969529
117Conjunctival telangiectasia (HP:0000524)1.94319740
118Atrial fibrillation (HP:0005110)1.94048755
119Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.93973386
120Vertebral hypoplasia (HP:0008417)1.93973386
121Cutaneous finger syndactyly (HP:0010554)1.93037451
122Increased variability in muscle fiber diameter (HP:0003557)1.92913930
123Abnormality of the neuromuscular junction (HP:0003398)1.92910162
124Fatigable weakness (HP:0003473)1.92910162
125Abnormality of the hepatic vasculature (HP:0006707)1.92824418
126Soft skin (HP:0000977)1.92241274
127Areflexia of lower limbs (HP:0002522)1.91278761
128Neonatal death (HP:0003811)1.91268382
129Cerebellar dysplasia (HP:0007033)1.90803645
130Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.90448588
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.89869189
132Hip contracture (HP:0003273)1.88963862
133Aplasia cutis congenita (HP:0001057)1.87229939
134Cardiovascular calcification (HP:0011915)1.86469111
135Cavernous hemangioma (HP:0001048)1.86356753
136Tetany (HP:0001281)1.85230454
137Abnormality of skeletal muscle fiber size (HP:0012084)1.85103521
138Abnormality of the anterior chamber (HP:0000593)1.84930097
139Truncus arteriosus (HP:0001660)1.83833463
140Vascular calcification (HP:0004934)1.83266872
141Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82874402
142Abnormality of the aortic arch (HP:0012303)1.82835049
143Cutaneous syndactyly (HP:0012725)1.82797985
144Scotoma (HP:0000575)1.82104133
145Abnormal vertebral ossification (HP:0100569)1.81797167
146Split hand (HP:0001171)1.81763049
147Delayed CNS myelination (HP:0002188)1.81159325
148Abnormality of permanent molar morphology (HP:0011071)1.81013117
149Abnormality of the dental root (HP:0006486)1.81013117
150Taurodontia (HP:0000679)1.81013117
151Abnormal drinking behavior (HP:0030082)1.80977892
152Polydipsia (HP:0001959)1.80977892
153Patent foramen ovale (HP:0001655)1.80928940
154Hypomagnesemia (HP:0002917)1.79674485
155Preaxial foot polydactyly (HP:0001841)1.76455281
156Primary atrial arrhythmia (HP:0001692)1.76262272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.08388775
2KDR5.73917963
3EPHA23.08866134
4EPHB23.01542139
5TGFBR12.78773995
6TGFBR22.75579838
7PTK2B2.23242931
8RIPK12.09469951
9LATS21.95250693
10PAK41.94417829
11TTN1.92468294
12AKT31.91557670
13FER1.90160078
14MYLK1.80669502
15PTK61.79102069
16PDK21.58781269
17GRK11.57659821
18PKN21.50672189
19TRIB31.48422545
20WNK41.47401330
21DMPK1.43978503
22PTK21.36135580
23PRKG21.34240558
24MAP2K11.32337483
25FES1.31225590
26NTRK11.31033228
27FGFR41.27720204
28LATS11.25868261
29PDGFRA1.23014422
30MAP2K21.22169051
31MAP2K31.22082811
32STK391.04195609
33PNCK1.03360330
34PRKD11.00527485
35LMTK20.97483395
36ERBB40.96745973
37PAK20.93225407
38PRKD30.91650408
39MAP3K30.91364999
40LRRK20.89151251
41EPHB10.88746825
42BCR0.84881532
43TSSK60.77174102
44AKT20.75489018
45PDK40.74316256
46PDK30.74316256
47MET0.71036871
48MKNK20.69396676
49BMPR1B0.66234960
50RPS6KB20.65435807
51GSK3A0.65319041
52STK100.63696718
53MTOR0.62026410
54PRKAA20.60377828
55MAPK150.58453170
56TYRO30.57731486
57KSR20.54662073
58TESK10.53284202
59MAPK120.52892942
60PAK30.51874367
61MAP3K110.51789842
62STK30.50760863
63CDK40.50077994
64MAP3K80.49259113
65CDK60.49041885
66MST40.47783959
67ICK0.46808233
68ACVR1B0.46623302
69PRKD20.45966053
70ERN10.45868866
71ROCK20.45766282
72MAP3K10.45404443
73VRK10.43004648
74MAP3K100.41890708
75SRC0.41068041
76RPS6KA20.40992872
77MARK20.40729810
78INSR0.38817594
79ILK0.36503878
80CSK0.36203419
81BCKDK0.34764571
82IGF1R0.34688373
83FGFR20.33219411
84DAPK30.33147458
85ABL20.32674647
86STK38L0.32551843
87TBK10.32123675
88MAPK70.31856367
89INSRR0.31036110
90PAK10.30181807
91EEF2K0.30043082
92ARAF0.28954137
93MAPKAPK30.28135081
94ROCK10.27795231
95EGFR0.27017741
96RPS6KC10.26158231
97RPS6KL10.26158231
98NLK0.25940739
99FGFR10.25772892
100MAP3K120.25519062
101PDGFRB0.25037545
102PDPK10.24964199
103RET0.24885767
104NEK90.24701646
105OBSCN0.24141598
106EPHA30.23668173
107IRAK10.23605977
108SIK10.23563661
109MAP3K70.22416402
110ITK0.22310971
111BMX0.21690229
112RPS6KA60.21590050
113MAPK40.21288919
114TRPM70.20956975
115PRKCH0.20636704
116NTRK20.19274578
117TAOK10.19219497
118ALK0.18999017
119PRKAA10.18491800
120FGR0.18291284
121PRKCE0.18152510
122FLT30.17820382
123MAP3K20.17171483
124PKN10.16819159
125TEC0.16687197
126BRAF0.16458437
127PHKG10.16416896
128PHKG20.16416896
129ADRBK10.15439120
130NEK20.15314840
131WNK10.15197578
132NME10.13327047
133IKBKE0.13290823
134MOS0.12248273
135MAPK10.10034278
136CAMK10.09021528

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.95172951
2Small cell lung cancer_Homo sapiens_hsa052223.27589038
3Adherens junction_Homo sapiens_hsa045202.99302555
4Focal adhesion_Homo sapiens_hsa045102.97679784
5Amoebiasis_Homo sapiens_hsa051462.38556022
6Nitrogen metabolism_Homo sapiens_hsa009102.19774679
7Tight junction_Homo sapiens_hsa045302.13645079
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.06119422
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90523340
10Arginine biosynthesis_Homo sapiens_hsa002201.83996600
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82913203
12Dilated cardiomyopathy_Homo sapiens_hsa054141.71772675
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71032981
14Bile secretion_Homo sapiens_hsa049761.70778843
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70702218
16Malaria_Homo sapiens_hsa051441.66601786
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62575230
18Rap1 signaling pathway_Homo sapiens_hsa040151.60744252
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.57577674
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57524173
21African trypanosomiasis_Homo sapiens_hsa051431.54290608
22Arginine and proline metabolism_Homo sapiens_hsa003301.52457955
23Proteoglycans in cancer_Homo sapiens_hsa052051.51271178
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51182751
25Hippo signaling pathway_Homo sapiens_hsa043901.51173225
26Toxoplasmosis_Homo sapiens_hsa051451.47766732
27Legionellosis_Homo sapiens_hsa051341.43407561
28Notch signaling pathway_Homo sapiens_hsa043301.38624348
29HIF-1 signaling pathway_Homo sapiens_hsa040661.37882607
30TGF-beta signaling pathway_Homo sapiens_hsa043501.36788828
31Pathways in cancer_Homo sapiens_hsa052001.36274039
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34240473
33Protein digestion and absorption_Homo sapiens_hsa049741.31156570
34Basal cell carcinoma_Homo sapiens_hsa052171.26954063
35Fatty acid degradation_Homo sapiens_hsa000711.25647015
36Prion diseases_Homo sapiens_hsa050201.21553789
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20045219
38Complement and coagulation cascades_Homo sapiens_hsa046101.17096217
39Dorso-ventral axis formation_Homo sapiens_hsa043201.16333468
40Propanoate metabolism_Homo sapiens_hsa006401.15801118
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11286460
42Fat digestion and absorption_Homo sapiens_hsa049751.10851695
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10637934
44Renal cell carcinoma_Homo sapiens_hsa052111.10114801
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09736724
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.08797686
47MAPK signaling pathway_Homo sapiens_hsa040101.07242548
48PPAR signaling pathway_Homo sapiens_hsa033201.06830777
49Carbon metabolism_Homo sapiens_hsa012001.05753909
50Mineral absorption_Homo sapiens_hsa049781.04842182
51Axon guidance_Homo sapiens_hsa043601.04236426
52Insulin resistance_Homo sapiens_hsa049310.99804284
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99758748
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99355356
55Vitamin digestion and absorption_Homo sapiens_hsa049770.97606577
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94756786
57VEGF signaling pathway_Homo sapiens_hsa043700.93014740
58Lysine degradation_Homo sapiens_hsa003100.90531961
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89929236
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87622866
61Sulfur relay system_Homo sapiens_hsa041220.87220167
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86892061
63TNF signaling pathway_Homo sapiens_hsa046680.86524503
64Melanogenesis_Homo sapiens_hsa049160.84135409
65Platelet activation_Homo sapiens_hsa046110.82841450
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81823969
67Hedgehog signaling pathway_Homo sapiens_hsa043400.81498760
68Estrogen signaling pathway_Homo sapiens_hsa049150.81357733
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76732502
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.75952812
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75374107
72Ras signaling pathway_Homo sapiens_hsa040140.75118535
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74034471
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73639876
75Viral myocarditis_Homo sapiens_hsa054160.71512214
76Phototransduction_Homo sapiens_hsa047440.71455451
77Fatty acid metabolism_Homo sapiens_hsa012120.70995572
78Bladder cancer_Homo sapiens_hsa052190.69906162
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69725357
80Cardiac muscle contraction_Homo sapiens_hsa042600.69618112
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69004630
82Thyroid cancer_Homo sapiens_hsa052160.66551530
83Gap junction_Homo sapiens_hsa045400.66095428
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65897697
85Ribosome_Homo sapiens_hsa030100.65589870
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.64011036
87Glucagon signaling pathway_Homo sapiens_hsa049220.62682003
88Pyruvate metabolism_Homo sapiens_hsa006200.62607840
89MicroRNAs in cancer_Homo sapiens_hsa052060.61242207
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60331380
91cAMP signaling pathway_Homo sapiens_hsa040240.59845130
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58857995
93Tryptophan metabolism_Homo sapiens_hsa003800.58180627
94Endocytosis_Homo sapiens_hsa041440.55653040
95Prostate cancer_Homo sapiens_hsa052150.54609767
96Galactose metabolism_Homo sapiens_hsa000520.53836775
97Hepatitis C_Homo sapiens_hsa051600.53408959
98AMPK signaling pathway_Homo sapiens_hsa041520.52944430
99Biosynthesis of amino acids_Homo sapiens_hsa012300.51955599
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50679154
101Renin-angiotensin system_Homo sapiens_hsa046140.50187779
102Shigellosis_Homo sapiens_hsa051310.49873667
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49436322
104beta-Alanine metabolism_Homo sapiens_hsa004100.45864038
105Renin secretion_Homo sapiens_hsa049240.45219507
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44941239
107Thyroid hormone synthesis_Homo sapiens_hsa049180.44937189
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43845055
109HTLV-I infection_Homo sapiens_hsa051660.42651308
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.41896642
111Ovarian steroidogenesis_Homo sapiens_hsa049130.41555328
112* Wnt signaling pathway_Homo sapiens_hsa043100.41049021
113ErbB signaling pathway_Homo sapiens_hsa040120.41021493
114Oxytocin signaling pathway_Homo sapiens_hsa049210.39724928
115Salmonella infection_Homo sapiens_hsa051320.39277716
116Melanoma_Homo sapiens_hsa052180.36625495
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35280848
118Choline metabolism in cancer_Homo sapiens_hsa052310.34478813
119Chronic myeloid leukemia_Homo sapiens_hsa052200.33524972
120Pertussis_Homo sapiens_hsa051330.33345383
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.32868349
122Gastric acid secretion_Homo sapiens_hsa049710.29853468
123Retinol metabolism_Homo sapiens_hsa008300.29241840
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28824068
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26944467
126GnRH signaling pathway_Homo sapiens_hsa049120.26317773
127Insulin signaling pathway_Homo sapiens_hsa049100.25717601
128Sulfur metabolism_Homo sapiens_hsa009200.24069635
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23174012
130FoxO signaling pathway_Homo sapiens_hsa040680.23124286
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21564341
132Cocaine addiction_Homo sapiens_hsa050300.21556782
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.20343452
134Influenza A_Homo sapiens_hsa051640.20056507

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