SOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.87096240
2regulation of posttranscriptional gene silencing (GO:0060147)6.87096240
3regulation of gene silencing by miRNA (GO:0060964)6.87096240
4presynaptic membrane assembly (GO:0097105)5.23303818
5central nervous system myelination (GO:0022010)5.22702545
6axon ensheathment in central nervous system (GO:0032291)5.22702545
7neuron fate determination (GO:0048664)4.81363470
8regulation of helicase activity (GO:0051095)4.67302509
9presynaptic membrane organization (GO:0097090)4.65147747
10viral transcription (GO:0019083)4.51855950
11paraxial mesoderm development (GO:0048339)4.50313024
12negative regulation of oligodendrocyte differentiation (GO:0048715)4.48912854
13postsynaptic membrane organization (GO:0001941)4.48200760
14establishment of apical/basal cell polarity (GO:0035089)4.44623915
15otic vesicle formation (GO:0030916)4.37158249
16nuclear pore organization (GO:0006999)4.37087945
17translational termination (GO:0006415)4.34608160
18pre-miRNA processing (GO:0031054)4.30584748
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.26068484
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.26068484
21DNA replication-dependent nucleosome assembly (GO:0006335)4.20679370
22DNA replication-dependent nucleosome organization (GO:0034723)4.20679370
23DNA unwinding involved in DNA replication (GO:0006268)4.18976403
24anterior/posterior axis specification, embryo (GO:0008595)4.15888018
25determination of adult lifespan (GO:0008340)4.09843423
26nuclear pore complex assembly (GO:0051292)4.07486901
27positive regulation of SMAD protein import into nucleus (GO:0060391)4.06846345
28* neuronal stem cell maintenance (GO:0097150)4.05574986
29heterochromatin organization (GO:0070828)4.00430104
30regulation of hippo signaling (GO:0035330)3.98517558
31regulation of histone H3-K9 methylation (GO:0051570)3.94166636
32establishment of monopolar cell polarity (GO:0061162)3.90588286
33establishment or maintenance of monopolar cell polarity (GO:0061339)3.90588286
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89480364
35radial glial cell differentiation (GO:0060019)3.87261631
36protein localization to kinetochore (GO:0034501)3.83395225
37neuron cell-cell adhesion (GO:0007158)3.82831277
38negative regulation of glial cell differentiation (GO:0045686)3.81104946
39negative regulation of histone methylation (GO:0031061)3.80408791
40ribosomal small subunit assembly (GO:0000028)3.71350783
41regulation of gene silencing (GO:0060968)3.69056707
42histone arginine methylation (GO:0034969)3.68542355
43mitotic sister chromatid segregation (GO:0000070)3.65865816
44cell proliferation in forebrain (GO:0021846)3.64428918
45DNA replication initiation (GO:0006270)3.63408272
46cranial nerve development (GO:0021545)3.63071694
47histone H4-K12 acetylation (GO:0043983)3.60981913
48regulation of translational fidelity (GO:0006450)3.59832881
49negative regulation of astrocyte differentiation (GO:0048712)3.57525513
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57003731
51planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56206546
52outer ear morphogenesis (GO:0042473)3.52455389
53somite development (GO:0061053)3.52395338
54axonemal dynein complex assembly (GO:0070286)3.51006029
55mitotic metaphase plate congression (GO:0007080)3.49760981
56cotranslational protein targeting to membrane (GO:0006613)3.45431288
57negative regulation of gene silencing (GO:0060969)3.45085267
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44735202
59regulation of telomere maintenance via telomerase (GO:0032210)3.44260515
60polarized epithelial cell differentiation (GO:0030859)3.43503477
61midbrain development (GO:0030901)3.40487260
62translational elongation (GO:0006414)3.38518221
63regulation of SMAD protein import into nucleus (GO:0060390)3.38062640
64protein targeting to ER (GO:0045047)3.37930687
65DNA geometric change (GO:0032392)3.37388845
66sister chromatid segregation (GO:0000819)3.37256476
67DNA duplex unwinding (GO:0032508)3.36523984
68peptidyl-arginine omega-N-methylation (GO:0035247)3.34661747
69positive regulation of chromosome segregation (GO:0051984)3.33231971
70notochord development (GO:0030903)3.32020385
71cellular protein complex disassembly (GO:0043624)3.31607631
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30418555
73chromatin assembly (GO:0031497)3.26667393
74formation of translation preinitiation complex (GO:0001731)3.25320420
75mitotic nuclear envelope disassembly (GO:0007077)3.24166016
76ribosomal small subunit biogenesis (GO:0042274)3.23934063
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22873983
78convergent extension (GO:0060026)3.20903241
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.20726119
80heart valve formation (GO:0003188)3.18780489
81viral life cycle (GO:0019058)3.18676133
82limb bud formation (GO:0060174)3.18295908
83folic acid-containing compound biosynthetic process (GO:0009396)3.17890554
84regulation of sister chromatid cohesion (GO:0007063)3.17226762
85regulation of timing of cell differentiation (GO:0048505)3.15431029
86limb development (GO:0060173)3.14777701
87appendage development (GO:0048736)3.14777701
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.13919645
89cellular response to cholesterol (GO:0071397)3.12624570
90regulation of development, heterochronic (GO:0040034)3.11207195
91nephron epithelium morphogenesis (GO:0072088)3.08110170
92nephron tubule morphogenesis (GO:0072078)3.08110170
93pyrimidine nucleobase catabolic process (GO:0006208)3.07917312
94protein localization to endoplasmic reticulum (GO:0070972)3.06673665
95protein localization to chromosome, centromeric region (GO:0071459)3.05981297
96metaphase plate congression (GO:0051310)3.05174809
97membrane disassembly (GO:0030397)3.04570596
98nuclear envelope disassembly (GO:0051081)3.04570596
99epithelial cilium movement (GO:0003351)3.04269317
100pattern specification involved in kidney development (GO:0061004)3.03649832
101protein K6-linked ubiquitination (GO:0085020)3.03345716
102protein complex disassembly (GO:0043241)3.02353324
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.99657682
104spliceosomal tri-snRNP complex assembly (GO:0000244)2.99101880
105IMP biosynthetic process (GO:0006188)2.98062242
106regulation of non-canonical Wnt signaling pathway (GO:2000050)2.97730672
107regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.97172832
108peptidyl-arginine methylation (GO:0018216)2.96887810
109peptidyl-arginine N-methylation (GO:0035246)2.96887810
110lateral sprouting from an epithelium (GO:0060601)2.96804532
111cilium movement (GO:0003341)2.96583042
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96518142
113establishment of planar polarity (GO:0001736)2.95859358
114establishment of tissue polarity (GO:0007164)2.95859358
115DNA strand elongation involved in DNA replication (GO:0006271)2.95805291
116cell fate commitment involved in formation of primary germ layer (GO:0060795)2.94820046
117thalamus development (GO:0021794)2.94338102
118spindle assembly involved in mitosis (GO:0090307)2.94304980
119histone H4-K8 acetylation (GO:0043982)2.93859171
120histone H4-K5 acetylation (GO:0043981)2.93859171
121histone H2A monoubiquitination (GO:0035518)2.91680429
122lens fiber cell development (GO:0070307)2.91454095
123pore complex assembly (GO:0046931)2.91377938
124regulation of oligodendrocyte differentiation (GO:0048713)2.91246510
125nucleobase biosynthetic process (GO:0046112)2.91143021
126nonmotile primary cilium assembly (GO:0035058)2.90846293
127negative regulation of mRNA processing (GO:0050686)2.90478569
128vocalization behavior (GO:0071625)2.89559108
129axonal fasciculation (GO:0007413)2.86410298
130establishment of integrated proviral latency (GO:0075713)2.85522740
131lung-associated mesenchyme development (GO:0060484)2.83351654
132regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80318726
133regulation of mitotic spindle organization (GO:0060236)2.79976048
134macromolecular complex disassembly (GO:0032984)2.78863103
135apoptotic process involved in morphogenesis (GO:0060561)2.78554556
136regulation of centrosome cycle (GO:0046605)2.78369985
137astrocyte differentiation (GO:0048708)2.78335919
138DNA strand elongation (GO:0022616)2.78237988
139somatic stem cell division (GO:0048103)2.77677830
140ribosome biogenesis (GO:0042254)2.76861498
141negative regulation of androgen receptor signaling pathway (GO:0060766)2.76486747
142spinal cord development (GO:0021510)2.76003799
143* cell-cell signaling involved in cell fate commitment (GO:0045168)2.75626807
144maturation of SSU-rRNA (GO:0030490)2.74645142
145regulation of chromatin silencing (GO:0031935)2.74458761
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73929958
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73929958
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.73929958
149digestive tract morphogenesis (GO:0048546)2.71037985
150trophectodermal cell differentiation (GO:0001829)2.69417108
151regulation of astrocyte differentiation (GO:0048710)2.69160676
152DNA replication checkpoint (GO:0000076)2.68888302
153negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.68441892
154regulation of RNA export from nucleus (GO:0046831)2.67616030
155protein complex localization (GO:0031503)2.67500100
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67158884
157regulation of cell fate specification (GO:0042659)2.67143409
158microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.66839637
159translational initiation (GO:0006413)2.66462349
160negative regulation of gliogenesis (GO:0014014)2.65995894
161cerebral cortex radially oriented cell migration (GO:0021799)2.64349107
162cochlea development (GO:0090102)2.64256582
163dermatan sulfate biosynthetic process (GO:0030208)2.64187148
164regulation of chromosome segregation (GO:0051983)2.61556812
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61416988
166chaperone-mediated protein complex assembly (GO:0051131)2.60766500
167regulation of spindle organization (GO:0090224)2.60200010
168intra-S DNA damage checkpoint (GO:0031573)2.60160701
169ribosome assembly (GO:0042255)2.60056713
170negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.59824971
171regulation of centriole replication (GO:0046599)2.59786049
172telencephalon development (GO:0021537)2.59530840
173mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59488237
174chromatin remodeling at centromere (GO:0031055)2.58808756
175non-canonical Wnt signaling pathway (GO:0035567)2.58162705
176mitotic G1 DNA damage checkpoint (GO:0031571)2.57278979
177nodal signaling pathway (GO:0038092)2.56918048
178negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.56270251
179neuron recognition (GO:0008038)2.55915116
180negative regulation of mRNA metabolic process (GO:1903312)2.55538072
181establishment of chromosome localization (GO:0051303)2.55410875
182establishment of protein localization to mitochondrial membrane (GO:0090151)2.55041295
183negative regulation of smoothened signaling pathway (GO:0045879)2.54285191
184dosage compensation (GO:0007549)2.54262532
185negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53687906
186negative regulation of translation, ncRNA-mediated (GO:0040033)2.53687906
187regulation of translation, ncRNA-mediated (GO:0045974)2.53687906
188L-serine metabolic process (GO:0006563)2.52374617
189retinal ganglion cell axon guidance (GO:0031290)2.52307360
190regulation of establishment of planar polarity (GO:0090175)2.49433739
191positive regulation of synapse assembly (GO:0051965)2.48755777
192positive regulation of vascular permeability (GO:0043117)2.48563650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.19845600
2EZH2_22144423_ChIP-Seq_EOC_Human5.20176004
3* KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.38094161
4* KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.38094161
5* KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.38094161
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.85513940
7* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.63712515
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.39890875
9* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.27570673
10* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.17190995
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15774620
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11080532
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.09113134
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.02647392
15* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.91839899
16* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.90504346
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89241791
18* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.72957155
19SOX2_18555785_ChIP-Seq_MESCs_Mouse2.71636289
20* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.66154758
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65819796
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.64659164
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53184114
24* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.51757762
25* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.43574023
26* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.40832779
27* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.39411829
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35123675
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33370816
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31400920
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.30516732
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.30513107
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24372687
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.16108917
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08643788
36JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04827043
37* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.04242801
38* POU5F1_16518401_ChIP-PET_MESCs_Mouse2.01205446
39* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01071128
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00488388
41* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99200746
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97704285
43* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.95700039
44* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93987995
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89341389
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89258714
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88663885
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83980647
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83980647
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81458832
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78883352
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77603164
53* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76797550
54* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.76534029
55* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.75467983
56* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75336714
57FUS_26573619_Chip-Seq_HEK293_Human1.72861485
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71873064
59* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.71798405
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70631657
61* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.67383528
62GBX2_23144817_ChIP-Seq_PC3_Human1.67260484
63* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.66437067
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63703325
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.62581638
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61490381
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60320003
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59507037
69* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58015999
70* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.57646548
71AR_21572438_ChIP-Seq_LNCaP_Human1.57438242
72XRN2_22483619_ChIP-Seq_HELA_Human1.57383775
73REST_21632747_ChIP-Seq_MESCs_Mouse1.56970665
74* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56295238
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.55716969
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54454076
77ZNF274_21170338_ChIP-Seq_K562_Hela1.54411029
78RNF2_27304074_Chip-Seq_NSC_Mouse1.53608050
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51727119
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51143692
81* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.51066435
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.50718180
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.49903535
84EWS_26573619_Chip-Seq_HEK293_Human1.48926748
85* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.47983850
86* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46652718
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45684814
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44244849
89* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44140891
90* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43628120
91* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43628120
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40432616
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.40217471
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39406764
95* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.39361582
96* P300_19829295_ChIP-Seq_ESCs_Human1.37484143
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.36292523
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36207294
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.35159239
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34638607
101* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32023527
102* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31819367
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31155602
104AR_21909140_ChIP-Seq_LNCAP_Human1.30726150
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.30669007
106* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30660734
107* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29994480
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28967183
109* SOX2_16153702_ChIP-ChIP_HESCs_Human1.28084796
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.22348732
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22018622
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21346791
113VDR_22108803_ChIP-Seq_LS180_Human1.21088265
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20645163
115ZNF263_19887448_ChIP-Seq_K562_Human1.20013131
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19254750
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15875798
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15672754
119SOX9_26525672_Chip-Seq_HEART_Mouse1.15523189
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14932519
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.13408362
122* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13355347
123* NANOG_16518401_ChIP-PET_MESCs_Mouse1.13222540
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13199002
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.13024713
126ETS1_20019798_ChIP-Seq_JURKAT_Human1.12551637
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12265932
128* ISL1_27105846_Chip-Seq_CPCs_Mouse1.11539869
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10943770
130TTF2_22483619_ChIP-Seq_HELA_Human1.10428586
131* KAP1_27257070_Chip-Seq_ESCs_Mouse1.09928496
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09781712
133ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08849526
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.08628994
135* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07385081
136MYC_18940864_ChIP-ChIP_HL60_Human1.06246484
137* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05537414
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05257042
139YY1_21170310_ChIP-Seq_MESCs_Mouse1.04750593
140CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03613766
141ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02788162
142* NANOG_16153702_ChIP-ChIP_HESCs_Human1.02411260
143* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02340450
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01809033
145SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01447212
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01247293
147TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01088067
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00747207
149REST_18959480_ChIP-ChIP_MESCs_Mouse1.00542065
150TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00116109
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.99412001
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94382368
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92688494
154* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92372758
155MYC_22102868_ChIP-Seq_BL_Human0.91981173
156KDM5A_27292631_Chip-Seq_BREAST_Human0.89978453
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87627177
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82216663
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79196362
160TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76210103
161DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76013621
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75944878
163TP63_17297297_ChIP-ChIP_HaCaT_Human0.75524208
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.75281426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.95604943
2MP0000566_synostosis3.65732988
3MP0008057_abnormal_DNA_replication3.55733068
4MP0004957_abnormal_blastocyst_morpholog3.30632202
5MP0003111_abnormal_nucleus_morphology3.17023608
6MP0004133_heterotaxia3.16514430
7MP0010094_abnormal_chromosome_stability3.04604425
8* MP0003136_yellow_coat_color2.92307188
9MP0003283_abnormal_digestive_organ2.79199364
10MP0003077_abnormal_cell_cycle2.64130501
11MP0010030_abnormal_orbit_morphology2.36195883
12MP0003693_abnormal_embryo_hatching2.35853849
13MP0003890_abnormal_embryonic-extraembry2.25246347
14MP0003880_abnormal_central_pattern2.20956360
15* MP0002084_abnormal_developmental_patter2.15043414
16MP0003941_abnormal_skin_development2.12150534
17* MP0002085_abnormal_embryonic_tissue2.09777829
18MP0006292_abnormal_olfactory_placode2.09397026
19MP0001730_embryonic_growth_arrest2.07853674
20MP0000350_abnormal_cell_proliferation2.07566591
21MP0003119_abnormal_digestive_system2.07412494
22MP0010352_gastrointestinal_tract_polyps2.05305145
23MP0002938_white_spotting2.03273731
24MP0008932_abnormal_embryonic_tissue1.99603934
25MP0008058_abnormal_DNA_repair1.98173940
26MP0003806_abnormal_nucleotide_metabolis1.90837037
27MP0004197_abnormal_fetal_growth/weight/1.88414307
28MP0003122_maternal_imprinting1.83309148
29MP0005380_embryogenesis_phenotype1.81450919
30MP0001672_abnormal_embryogenesis/_devel1.81450919
31* MP0002653_abnormal_ependyma_morphology1.76988453
32MP0004885_abnormal_endolymph1.75845964
33MP0003123_paternal_imprinting1.72111905
34MP0005623_abnormal_meninges_morphology1.69926772
35MP0001697_abnormal_embryo_size1.68721912
36MP0005076_abnormal_cell_differentiation1.67961891
37* MP0001293_anophthalmia1.66763351
38* MP0000631_abnormal_neuroendocrine_gland1.65676395
39MP0001984_abnormal_olfaction1.63495369
40MP0001299_abnormal_eye_distance/1.63286586
41MP0000537_abnormal_urethra_morphology1.62171014
42MP0001849_ear_inflammation1.61296570
43* MP0000026_abnormal_inner_ear1.59029806
44* MP0003861_abnormal_nervous_system1.57413869
45* MP0002086_abnormal_extraembryonic_tissu1.57408871
46MP0003984_embryonic_growth_retardation1.48665973
47MP0008007_abnormal_cellular_replicative1.48419056
48MP0004859_abnormal_synaptic_plasticity1.47937654
49MP0001529_abnormal_vocalization1.47782519
50MP0003937_abnormal_limbs/digits/tail_de1.46690956
51MP0002088_abnormal_embryonic_growth/wei1.45882793
52MP0005499_abnormal_olfactory_system1.45249370
53MP0005394_taste/olfaction_phenotype1.45249370
54MP0000579_abnormal_nail_morphology1.44055396
55MP0006072_abnormal_retinal_apoptosis1.44033975
56MP0010307_abnormal_tumor_latency1.42908421
57* MP0002080_prenatal_lethality1.38964575
58MP0003121_genomic_imprinting1.38109679
59MP0001346_abnormal_lacrimal_gland1.36552467
60* MP0000955_abnormal_spinal_cord1.36530237
61MP0001486_abnormal_startle_reflex1.36473471
62MP0009053_abnormal_anal_canal1.35728080
63MP0005171_absent_coat_pigmentation1.34977527
64MP0002638_abnormal_pupillary_reflex1.33466742
65MP0008789_abnormal_olfactory_epithelium1.32798341
66MP0002111_abnormal_tail_morphology1.30458949
67MP0003705_abnormal_hypodermis_morpholog1.30040921
68* MP0001286_abnormal_eye_development1.26488020
69MP0000049_abnormal_middle_ear1.26145668
70MP0004858_abnormal_nervous_system1.25169272
71MP0003635_abnormal_synaptic_transmissio1.23802724
72MP0005423_abnormal_somatic_nervous1.23250177
73MP0002736_abnormal_nociception_after1.21547633
74MP0003942_abnormal_urinary_system1.21151290
75MP0000432_abnormal_head_morphology1.20372700
76MP0000428_abnormal_craniofacial_morphol1.19248986
77* MP0003755_abnormal_palate_morphology1.18608837
78* MP0002697_abnormal_eye_size1.16381591
79* MP0000778_abnormal_nervous_system1.14705574
80MP0008877_abnormal_DNA_methylation1.14509745
81MP0002572_abnormal_emotion/affect_behav1.14374525
82MP0002063_abnormal_learning/memory/cond1.13956366
83MP0009745_abnormal_behavioral_response1.13553804
84MP0002734_abnormal_mechanical_nocicepti1.10883018
85MP0010234_abnormal_vibrissa_follicle1.10398389
86MP0004742_abnormal_vestibular_system1.09732725
87MP0003786_premature_aging1.09640140
88MP0002557_abnormal_social/conspecific_i1.07538833
89MP0009703_decreased_birth_body1.05310646
90MP0003938_abnormal_ear_development1.04198814
91MP0005377_hearing/vestibular/ear_phenot1.04161542
92MP0003878_abnormal_ear_physiology1.04161542
93MP0000516_abnormal_urinary_system1.03708178
94MP0005367_renal/urinary_system_phenotyp1.03708178
95MP0003935_abnormal_craniofacial_develop1.02679923
96MP0003567_abnormal_fetal_cardiomyocyte1.02184764
97MP0002233_abnormal_nose_morphology1.01933114
98* MP0002752_abnormal_somatic_nervous1.01743047
99* MP0002064_seizures1.01670195
100* MP0002210_abnormal_sex_determination1.01363819
101MP0002234_abnormal_pharynx_morphology1.01116811
102* MP0002092_abnormal_eye_morphology1.00147767
103* MP0001963_abnormal_hearing_physiology0.99649337
104* MP0001145_abnormal_male_reproductive0.99406192
105* MP0005195_abnormal_posterior_eye0.99404847
106* MP0002882_abnormal_neuron_morphology0.98908693
107MP0000647_abnormal_sebaceous_gland0.98547072
108MP0003950_abnormal_plasma_membrane0.98139442
109MP0003718_maternal_effect0.97204373
110* MP0002152_abnormal_brain_morphology0.97167438
111MP0002822_catalepsy0.97056550
112MP0002116_abnormal_craniofacial_bone0.96116917
113* MP0002249_abnormal_larynx_morphology0.95932965
114MP0009250_abnormal_appendicular_skeleto0.94686123
115* MP0001485_abnormal_pinna_reflex0.94291690
116MP0009672_abnormal_birth_weight0.93526836
117MP0001502_abnormal_circadian_rhythm0.92899400
118MP0002735_abnormal_chemical_nociception0.92751247
119* MP0002272_abnormal_nervous_system0.92535865
120MP0004233_abnormal_muscle_weight0.91249542
121MP0005084_abnormal_gallbladder_morpholo0.89747052
122MP0002751_abnormal_autonomic_nervous0.89359629
123MP0002928_abnormal_bile_duct0.88645445
124MP0005248_abnormal_Harderian_gland0.88412171
125* MP0000762_abnormal_tongue_morphology0.88410792
126MP0001968_abnormal_touch/_nociception0.88343599
127MP0000534_abnormal_ureter_morphology0.87636778
128MP0002184_abnormal_innervation0.87597311
129MP0002102_abnormal_ear_morphology0.85315601
130MP0005501_abnormal_skin_physiology0.84730596
131MP0002114_abnormal_axial_skeleton0.84213108
132MP0005187_abnormal_penis_morphology0.83464830
133MP0000462_abnormal_digestive_system0.83263267
134MP0005253_abnormal_eye_physiology0.82656097
135MP0003315_abnormal_perineum_morphology0.82619994
136MP0005551_abnormal_eye_electrophysiolog0.82453283
137MP0009384_cardiac_valve_regurgitation0.82240128
138MP0001177_atelectasis0.81453918
139MP0000313_abnormal_cell_death0.80889798
140* MP0002081_perinatal_lethality0.80704325
141MP0002932_abnormal_joint_morphology0.79914510
142MP0001348_abnormal_lacrimal_gland0.79790475
143MP0004264_abnormal_extraembryonic_tissu0.79515500
144MP0003566_abnormal_cell_adhesion0.79280316
145* MP0005391_vision/eye_phenotype0.78908368
146MP0003936_abnormal_reproductive_system0.78744204
147MP0005266_abnormal_metabolism0.77983037
148MP0002796_impaired_skin_barrier0.77096637
149MP0008770_decreased_survivor_rate0.76433899
150MP0002925_abnormal_cardiovascular_devel0.76232434
151* MP0000467_abnormal_esophagus_morphology0.75388048
152MP0003115_abnormal_respiratory_system0.75233888

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.49977872
2Astrocytoma (HP:0009592)4.56606928
3Abnormality of the astrocytes (HP:0100707)4.56606928
4Abnormality of the labia minora (HP:0012880)4.50110839
5* Septo-optic dysplasia (HP:0100842)4.07903798
6Neoplasm of the oral cavity (HP:0100649)3.95796046
7Medulloblastoma (HP:0002885)3.93255581
8Glioma (HP:0009733)3.68402549
9Supernumerary spleens (HP:0009799)3.67376816
10Partial duplication of the phalanx of hand (HP:0009999)3.60191811
11Absent radius (HP:0003974)3.37402680
12Absent forearm bone (HP:0003953)3.33715089
13Aplasia involving forearm bones (HP:0009822)3.33715089
14Split foot (HP:0001839)3.31398817
15Rhabdomyosarcoma (HP:0002859)3.21377605
16Colon cancer (HP:0003003)3.15862546
17True hermaphroditism (HP:0010459)3.08106005
18Selective tooth agenesis (HP:0001592)3.04454616
19Abnormality of the salivary glands (HP:0010286)3.01634578
20Neoplasm of striated muscle (HP:0009728)2.95896164
21Abnormal number of incisors (HP:0011064)2.94186886
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.92331721
23Aplasia/hypoplasia of the humerus (HP:0006507)2.91261474
24Abdominal situs inversus (HP:0003363)2.89988501
25Abnormality of abdominal situs (HP:0011620)2.89988501
26Abnormal ciliary motility (HP:0012262)2.87821460
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.87522789
28Absent/shortened dynein arms (HP:0200106)2.87522789
29Short humerus (HP:0005792)2.85035067
30Abnormality of the 4th metacarpal (HP:0010012)2.85027302
31Abnormal respiratory motile cilium physiology (HP:0012261)2.84887854
32Breast hypoplasia (HP:0003187)2.82568342
33Abnormal respiratory motile cilium morphology (HP:0005938)2.77543170
34Abnormal respiratory epithelium morphology (HP:0012253)2.77543170
35Agnosia (HP:0010524)2.77029959
36Coronal craniosynostosis (HP:0004440)2.76370482
37Bronchomalacia (HP:0002780)2.71715312
38Rectal fistula (HP:0100590)2.71011448
39Rectovaginal fistula (HP:0000143)2.71011448
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66691990
41Short 4th metacarpal (HP:0010044)2.66691990
42Pancreatic fibrosis (HP:0100732)2.66345101
43Shawl scrotum (HP:0000049)2.59348298
44Abnormality of cells of the erythroid lineage (HP:0012130)2.59052648
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58677657
46* Maternal diabetes (HP:0009800)2.56036114
47Pseudobulbar signs (HP:0002200)2.48182576
48Chromsome breakage (HP:0040012)2.47843623
49* Absent septum pellucidum (HP:0001331)2.44550357
50Megalencephaly (HP:0001355)2.42524758
51Abnormal number of erythroid precursors (HP:0012131)2.39709088
52Nephronophthisis (HP:0000090)2.38252286
53Bilateral microphthalmos (HP:0007633)2.38229706
54Patellar aplasia (HP:0006443)2.36831022
55Abnormality of the lower motor neuron (HP:0002366)2.35836462
56Facial hemangioma (HP:0000329)2.34065575
57Biliary tract neoplasm (HP:0100574)2.31786391
58Aplasia of the phalanges of the hand (HP:0009802)2.31430151
59Aplasia involving bones of the extremities (HP:0009825)2.31430151
60Aplasia involving bones of the upper limbs (HP:0009823)2.31430151
61* Optic nerve hypoplasia (HP:0000609)2.30399708
62Macrocytic anemia (HP:0001972)2.29920993
63Intestinal fistula (HP:0100819)2.26266095
64Impulsivity (HP:0100710)2.25609696
65Vaginal fistula (HP:0004320)2.24838633
66Abnormality of midbrain morphology (HP:0002418)2.24441094
67Molar tooth sign on MRI (HP:0002419)2.24441094
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.20066462
69Rhinitis (HP:0012384)2.19815596
70Asplenia (HP:0001746)2.19384684
71Abnormality of the parietal bone (HP:0002696)2.18431081
72Stenosis of the external auditory canal (HP:0000402)2.18220936
73Aplasia/Hypoplasia of the patella (HP:0006498)2.18212182
74Birth length less than 3rd percentile (HP:0003561)2.18146958
75Large earlobe (HP:0009748)2.17776312
76Abnormality of the middle phalanges of the toes (HP:0010183)2.17246603
77Synostosis involving the elbow (HP:0003938)2.17173319
78Humeroradial synostosis (HP:0003041)2.17173319
79Trigonocephaly (HP:0000243)2.16863369
80Pancreatic cysts (HP:0001737)2.14771313
81* Abnormality of the diencephalon (HP:0010662)2.13275239
82Fibular hypoplasia (HP:0003038)2.12918758
83Abnormal sex determination (HP:0012244)2.10645964
84Sex reversal (HP:0012245)2.10645964
85Abnormality of the antihelix (HP:0009738)2.09475189
86* Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08515216
87Malignant gastrointestinal tract tumors (HP:0006749)2.07946110
88Gastrointestinal carcinoma (HP:0002672)2.07946110
8911 pairs of ribs (HP:0000878)2.07036886
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05822174
91Intestinal atresia (HP:0011100)2.05006075
92Anencephaly (HP:0002323)2.04144231
93Basal cell carcinoma (HP:0002671)2.02919199
94* Abnormality of the septum pellucidum (HP:0007375)2.02563640
95Broad alveolar ridges (HP:0000187)2.02019715
96Chronic bronchitis (HP:0004469)2.01324718
97Turricephaly (HP:0000262)2.01063491
98Broad metatarsal (HP:0001783)1.99147568
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.98863380
100Triphalangeal thumb (HP:0001199)1.98205111
101* Hemivertebrae (HP:0002937)1.97544507
102* Holoprosencephaly (HP:0001360)1.96960496
103Cutaneous finger syndactyly (HP:0010554)1.96534064
104Choanal stenosis (HP:0000452)1.96199464
105* Rib fusion (HP:0000902)1.94944606
106Hepatoblastoma (HP:0002884)1.93969321
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93923888
108Oligodactyly (HP:0012165)1.93398634
109Absent thumb (HP:0009777)1.93088270
110* Esophageal atresia (HP:0002032)1.92775604
111High anterior hairline (HP:0009890)1.92408359
112Proximal placement of thumb (HP:0009623)1.91969205
113Preaxial hand polydactyly (HP:0001177)1.91504981
114Fused cervical vertebrae (HP:0002949)1.89281566
115Atresia of the external auditory canal (HP:0000413)1.88755797
116Abnormality of the incisor (HP:0000676)1.88064004
117Vaginal atresia (HP:0000148)1.87803483
118Cutaneous syndactyly (HP:0012725)1.87486628
119Midline defect of the nose (HP:0004122)1.86489871
120Renal dysplasia (HP:0000110)1.85999762
121Increased nuchal translucency (HP:0010880)1.85763331
122Duplication of thumb phalanx (HP:0009942)1.85084935
123Deviation of the thumb (HP:0009603)1.84835783
124Abnormality of cochlea (HP:0000375)1.84601805
125Genital tract atresia (HP:0001827)1.84059129
126Abnormality of the ileum (HP:0001549)1.83943421
127Cerebral hypomyelination (HP:0006808)1.83787570
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.83556829
129Medial flaring of the eyebrow (HP:0010747)1.82915252
130Postaxial hand polydactyly (HP:0001162)1.81711649
131Cortical dysplasia (HP:0002539)1.81320586
132Abnormality of the renal medulla (HP:0100957)1.80812694
133Adactyly (HP:0009776)1.80079901
134* Gastrointestinal atresia (HP:0002589)1.79651573
135Bifid scrotum (HP:0000048)1.79633292
136Adenoma sebaceum (HP:0009720)1.79245955
137Angiofibromas (HP:0010615)1.79245955
138Skull defect (HP:0001362)1.78669919
139Gait imbalance (HP:0002141)1.78661356
140Meckel diverticulum (HP:0002245)1.78492176
141Neonatal short-limb short stature (HP:0008921)1.78090794
1422-3 toe syndactyly (HP:0004691)1.77841856
143Partial duplication of thumb phalanx (HP:0009944)1.76754427
144Hypoplasia of the ulna (HP:0003022)1.76745816
145Heterotopia (HP:0002282)1.76543225
146Reticulocytopenia (HP:0001896)1.76276463
147Breast aplasia (HP:0100783)1.76270514
148Focal motor seizures (HP:0011153)1.75965776
149Median cleft lip (HP:0000161)1.75916149
150Broad phalanges of the hand (HP:0009768)1.74727661
151Renal hypoplasia (HP:0000089)1.74101775
152Overriding aorta (HP:0002623)1.73819823
153Postaxial foot polydactyly (HP:0001830)1.73735468
154Oligodactyly (hands) (HP:0001180)1.72854871
155Carpal bone hypoplasia (HP:0001498)1.72601180
156Cystic liver disease (HP:0006706)1.72285020
157Duplicated collecting system (HP:0000081)1.72206527
158Morphological abnormality of the inner ear (HP:0011390)1.72020506
159Aplasia/Hypoplasia of the fibula (HP:0006492)1.70885001
160Abnormality of chromosome segregation (HP:0002916)1.70638685
161Sleep apnea (HP:0010535)1.69551715
162Broad finger (HP:0001500)1.69382393
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68878250
164Volvulus (HP:0002580)1.68776334
165Broad thumb (HP:0011304)1.67153556
166Preaxial foot polydactyly (HP:0001841)1.67054003
167Spinal muscular atrophy (HP:0007269)1.65150259
168Neoplasm of the pancreas (HP:0002894)1.64586973
169Aplasia/Hypoplasia of the breasts (HP:0010311)1.64181319
170* Anophthalmia (HP:0000528)1.63712988
171Small intestinal stenosis (HP:0012848)1.62851135
172Duodenal stenosis (HP:0100867)1.62851135
173Abnormal lung lobation (HP:0002101)1.62252984
174Nephroblastoma (Wilms tumor) (HP:0002667)1.61947065
175Abnormality of the duodenum (HP:0002246)1.60391854
176Ovarian neoplasm (HP:0100615)1.59956062
177Abnormality of chromosome stability (HP:0003220)1.59905681
178Synostosis of carpal bones (HP:0005048)1.59822895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.77328686
2CDK123.76919902
3EPHA23.45686017
4CDC73.16465200
5CASK3.01959417
6WEE12.98933224
7TTK2.67230646
8NEK12.55857677
9TNIK2.55312551
10PNCK2.51965385
11TYRO32.47305074
12ICK2.24664864
13BUB12.20470878
14FGFR22.19500246
15RPS6KB22.16324930
16EPHA41.96941422
17VRK21.88155278
18AKT31.81542602
19NEK21.80318844
20DDR21.76542842
21CDK71.73743263
22PLK11.69479001
23CHEK21.62247731
24TSSK61.58372212
25LATS21.56199212
26EEF2K1.50891421
27SRPK11.49091060
28MKNK11.45047941
29ALK1.44880828
30PASK1.42610470
31WNK31.42567867
32TAF11.39354341
33TLK11.39347716
34MKNK21.38691661
35BRD41.36965045
36MAP3K91.35462090
37CHEK11.30971661
38MET1.27718305
39TESK21.25120650
40CAMK1G1.21456090
41ATR1.18222443
42DYRK31.18214779
43PLK31.17993183
44CAMK1D1.17384343
45BRSK21.16135396
46ZAK1.15357562
47AURKA1.14584178
48MAP3K101.11670623
49UHMK11.09993496
50PAK41.08602625
51CDK21.06727879
52ERBB41.06514787
53CDK31.06296902
54AURKB1.06148937
55BMPR1B1.03055909
56PAK61.02839471
57NTRK31.02829928
58DYRK21.02769392
59LATS11.02605233
60MAP3K41.01649864
61WNK40.99457148
62CDK60.99324894
63MTOR0.98462946
64MAP3K80.97149476
65BMX0.96920117
66PRKCG0.95709751
67CSNK1D0.95602990
68ATM0.95482192
69CDK190.94371495
70CDK40.93765295
71PRKCI0.93202918
72NME10.93045370
73FGR0.90175645
74CSNK1E0.89350834
75KSR10.87242470
76PKN10.84658440
77PINK10.81517523
78CDK10.81111065
79NTRK20.79067602
80PKN20.78236946
81BCR0.77080654
82STK100.76949521
83INSRR0.76779117
84EPHA30.76348174
85PLK40.76295886
86AKT20.73569864
87MAP2K70.72843414
88PIM10.72324304
89TGFBR10.70718319
90SGK2230.70522532
91SGK4940.70522532
92STK160.68964787
93FGFR10.68858908
94STK30.67124380
95SCYL20.66952752
96CSNK2A20.65989677
97DYRK1A0.64124055
98BRSK10.63529429
99ERBB20.63167146
100DYRK1B0.62490169
101CDK11A0.62297890
102YES10.62176567
103STK38L0.60689743
104PAK20.60371542
105PRPF4B0.60296841
106PRKDC0.59298453
107STK40.59175164
108NLK0.59099278
109CDK150.58314631
110CDK140.56915661
111MAPK130.56727846
112MELK0.56217886
113PAK10.56211828
114NUAK10.54966888
115PLK20.54600304
116MAPKAPK30.53822155
117CDK180.53531659
118PDGFRA0.52537404
119GSK3B0.51721505
120VRK10.51458360
121ACVR1B0.49470463
122MAPK100.49082851
123SGK20.48980396
124MAPK140.48089167
125DMPK0.47526881
126MATK0.46747945
127EPHB20.46241740
128CSNK1G30.46235202
129GSK3A0.46037263
130NTRK10.44742769
131KSR20.43679933
132MARK10.43290346
133MAP2K20.43149819
134PRKD30.42578474
135CSNK1G20.42204520
136STK110.41917613
137MAPK10.41228695
138CSNK1A1L0.38950121
139ROCK20.38805784
140CAMK10.38660560
141CSNK2A10.38456667
142MAP2K40.36748623
143STK240.36331972
144CSNK1G10.35306255
145IRAK10.35272014
146PBK0.35226856
147MAPKAPK50.35155725
148FLT30.33809389
149STK390.33292356
150SGK10.33072528
151WNK10.31608081
152ROCK10.30694047
153PTK60.30511870

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.51391867
2DNA replication_Homo sapiens_hsa030303.76812935
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68623338
4Spliceosome_Homo sapiens_hsa030403.41387326
5RNA transport_Homo sapiens_hsa030133.30384822
6One carbon pool by folate_Homo sapiens_hsa006702.71849768
7mRNA surveillance pathway_Homo sapiens_hsa030152.68559663
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59249594
9Nucleotide excision repair_Homo sapiens_hsa034202.57168881
10Cell cycle_Homo sapiens_hsa041102.45887601
11Ribosome_Homo sapiens_hsa030102.33366944
12Base excision repair_Homo sapiens_hsa034102.31117895
13Oxidative phosphorylation_Homo sapiens_hsa001902.27582058
14Homologous recombination_Homo sapiens_hsa034402.27551921
15Basal cell carcinoma_Homo sapiens_hsa052172.25906222
16Fanconi anemia pathway_Homo sapiens_hsa034602.23174369
17Parkinsons disease_Homo sapiens_hsa050122.15471375
18Nicotine addiction_Homo sapiens_hsa050332.15006733
19* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.10079709
20Cardiac muscle contraction_Homo sapiens_hsa042602.05395360
21RNA polymerase_Homo sapiens_hsa030202.03871089
22* Hippo signaling pathway_Homo sapiens_hsa043901.97274615
23Huntingtons disease_Homo sapiens_hsa050161.94443722
24Hedgehog signaling pathway_Homo sapiens_hsa043401.76615050
25Notch signaling pathway_Homo sapiens_hsa043301.62990917
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58966243
27p53 signaling pathway_Homo sapiens_hsa041151.57419994
28Nitrogen metabolism_Homo sapiens_hsa009101.56542965
29RNA degradation_Homo sapiens_hsa030181.56240310
30Non-homologous end-joining_Homo sapiens_hsa034501.52133744
31Basal transcription factors_Homo sapiens_hsa030221.52044193
32MicroRNAs in cancer_Homo sapiens_hsa052061.39488675
33Alzheimers disease_Homo sapiens_hsa050101.37766894
34Oocyte meiosis_Homo sapiens_hsa041141.37357498
35Tight junction_Homo sapiens_hsa045301.36038435
36Protein export_Homo sapiens_hsa030601.33095208
37TGF-beta signaling pathway_Homo sapiens_hsa043501.32748968
38Steroid biosynthesis_Homo sapiens_hsa001001.32706396
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30161653
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.28553472
41Cocaine addiction_Homo sapiens_hsa050301.25586916
42Biosynthesis of amino acids_Homo sapiens_hsa012301.24516877
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22700220
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22684307
45Systemic lupus erythematosus_Homo sapiens_hsa053221.21536902
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21208975
47Wnt signaling pathway_Homo sapiens_hsa043101.18881751
48Taste transduction_Homo sapiens_hsa047421.17369998
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16234924
50Glutamatergic synapse_Homo sapiens_hsa047241.13133595
51Bladder cancer_Homo sapiens_hsa052191.13083655
52Pyrimidine metabolism_Homo sapiens_hsa002401.12525384
53Adherens junction_Homo sapiens_hsa045201.12206773
54GABAergic synapse_Homo sapiens_hsa047271.11245606
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06584402
56Phototransduction_Homo sapiens_hsa047441.03524639
57Colorectal cancer_Homo sapiens_hsa052101.01557730
58mTOR signaling pathway_Homo sapiens_hsa041501.01380273
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98553497
60Alcoholism_Homo sapiens_hsa050340.93511608
61Morphine addiction_Homo sapiens_hsa050320.91193735
62Thyroid cancer_Homo sapiens_hsa052160.89190143
63Viral carcinogenesis_Homo sapiens_hsa052030.89135641
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88465269
65beta-Alanine metabolism_Homo sapiens_hsa004100.83553300
66Insulin secretion_Homo sapiens_hsa049110.83219643
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.82534192
68Circadian entrainment_Homo sapiens_hsa047130.82194912
69Propanoate metabolism_Homo sapiens_hsa006400.81364874
70cAMP signaling pathway_Homo sapiens_hsa040240.78775450
71Amphetamine addiction_Homo sapiens_hsa050310.77349640
72Folate biosynthesis_Homo sapiens_hsa007900.77233401
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.77194239
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76586579
75Butanoate metabolism_Homo sapiens_hsa006500.74653640
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73844264
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71744099
78Pathways in cancer_Homo sapiens_hsa052000.70610738
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69757752
80Melanoma_Homo sapiens_hsa052180.69413203
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69307566
82Linoleic acid metabolism_Homo sapiens_hsa005910.68540763
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67349388
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67021483
85Fatty acid biosynthesis_Homo sapiens_hsa000610.65377583
86Endometrial cancer_Homo sapiens_hsa052130.64884069
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64789999
88Axon guidance_Homo sapiens_hsa043600.63954616
89HTLV-I infection_Homo sapiens_hsa051660.63904313
90Dopaminergic synapse_Homo sapiens_hsa047280.63304553
91Proteasome_Homo sapiens_hsa030500.62283447
92Dorso-ventral axis formation_Homo sapiens_hsa043200.60577997
93Epstein-Barr virus infection_Homo sapiens_hsa051690.59538984
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59357488
95Olfactory transduction_Homo sapiens_hsa047400.57504161
96Melanogenesis_Homo sapiens_hsa049160.55840627
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.54557137
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54421904
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53953888
100Histidine metabolism_Homo sapiens_hsa003400.53570976
101Lysine degradation_Homo sapiens_hsa003100.53418349
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52750995
103Proteoglycans in cancer_Homo sapiens_hsa052050.52622756
104Renal cell carcinoma_Homo sapiens_hsa052110.51259504
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50940059
106ErbB signaling pathway_Homo sapiens_hsa040120.50435346
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50246895
108Arginine and proline metabolism_Homo sapiens_hsa003300.49913314
109Fructose and mannose metabolism_Homo sapiens_hsa000510.48660312
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48532333
111Purine metabolism_Homo sapiens_hsa002300.46252181
112Small cell lung cancer_Homo sapiens_hsa052220.46177991
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44420341
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43856643
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43152149
116Cholinergic synapse_Homo sapiens_hsa047250.43147433
117Gastric acid secretion_Homo sapiens_hsa049710.42951156
118Vitamin digestion and absorption_Homo sapiens_hsa049770.42856259
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41874119
120Gap junction_Homo sapiens_hsa045400.41707041
121Serotonergic synapse_Homo sapiens_hsa047260.41509181
122Prostate cancer_Homo sapiens_hsa052150.41492073
123Thyroid hormone synthesis_Homo sapiens_hsa049180.40110070
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39453635
125Retinol metabolism_Homo sapiens_hsa008300.38764262
126Bile secretion_Homo sapiens_hsa049760.38254541
127Glutathione metabolism_Homo sapiens_hsa004800.37635035
128Sulfur relay system_Homo sapiens_hsa041220.36545220
129Selenocompound metabolism_Homo sapiens_hsa004500.34392132
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34015596
131Prion diseases_Homo sapiens_hsa050200.33815114
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33712216
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32716271
134Carbon metabolism_Homo sapiens_hsa012000.32229109
135Rap1 signaling pathway_Homo sapiens_hsa040150.31958801
136Chronic myeloid leukemia_Homo sapiens_hsa052200.28928812
137Estrogen signaling pathway_Homo sapiens_hsa049150.28810553
138Glioma_Homo sapiens_hsa052140.28696651
139Vitamin B6 metabolism_Homo sapiens_hsa007500.28521603
140HIF-1 signaling pathway_Homo sapiens_hsa040660.23859760
141AMPK signaling pathway_Homo sapiens_hsa041520.23803827
142Long-term depression_Homo sapiens_hsa047300.21964051
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21935352
144Non-small cell lung cancer_Homo sapiens_hsa052230.21615144
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19625540
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19147206
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19076537
148Choline metabolism in cancer_Homo sapiens_hsa052310.17525724
149Focal adhesion_Homo sapiens_hsa045100.17492596
150ECM-receptor interaction_Homo sapiens_hsa045120.13862770
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13408714
152Ras signaling pathway_Homo sapiens_hsa040140.13285395

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