SOX21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)7.37775829
2lung epithelium development (GO:0060428)6.25652788
3establishment of tissue polarity (GO:0007164)5.74972248
4establishment of planar polarity (GO:0001736)5.74972248
5planar cell polarity pathway involved in neural tube closure (GO:0090179)5.29142810
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.10696159
7axon extension involved in axon guidance (GO:0048846)5.10696159
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.90748313
9negative regulation of axon guidance (GO:1902668)4.81310105
10lung-associated mesenchyme development (GO:0060484)4.80803604
11establishment of apical/basal cell polarity (GO:0035089)4.57611062
12postsynaptic membrane organization (GO:0001941)4.43792523
13presynaptic membrane assembly (GO:0097105)4.41517672
14central nervous system myelination (GO:0022010)4.38796108
15axon ensheathment in central nervous system (GO:0032291)4.38796108
16epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.37566220
17negative regulation of oligodendrocyte differentiation (GO:0048715)4.36010492
18regulation of somitogenesis (GO:0014807)4.35571678
19neuronal stem cell maintenance (GO:0097150)4.31789497
20outer ear morphogenesis (GO:0042473)4.27702547
21neuron fate determination (GO:0048664)4.27262547
22negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.20871755
23forebrain neuron differentiation (GO:0021879)4.14344088
24retinal ganglion cell axon guidance (GO:0031290)4.12086670
25astrocyte differentiation (GO:0048708)4.11953659
26establishment of monopolar cell polarity (GO:0061162)4.10571563
27establishment or maintenance of monopolar cell polarity (GO:0061339)4.10571563
28otic vesicle formation (GO:0030916)4.07881777
29regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.06626203
30viral transcription (GO:0019083)4.05178857
31face development (GO:0060324)4.02921381
32dendritic spine morphogenesis (GO:0060997)3.99066929
33tongue development (GO:0043586)3.97566806
34limb development (GO:0060173)3.96957784
35appendage development (GO:0048736)3.96957784
36pyrimidine nucleobase catabolic process (GO:0006208)3.96086592
37paraxial mesoderm development (GO:0048339)3.90731369
38glomerular filtration (GO:0003094)3.89491789
39translational termination (GO:0006415)3.89062880
40limb bud formation (GO:0060174)3.84940436
41cell surface receptor signaling pathway involved in heart development (GO:0061311)3.83530936
42regulation of mesenchymal cell apoptotic process (GO:2001053)3.82756641
43negative regulation of axon extension involved in axon guidance (GO:0048843)3.81149747
44renal filtration (GO:0097205)3.81026928
45cell proliferation in forebrain (GO:0021846)3.80144188
46G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.78600754
47epithelial cell differentiation involved in prostate gland development (GO:0060742)3.77861563
48lens fiber cell development (GO:0070307)3.77533963
49negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.76377611
50presynaptic membrane organization (GO:0097090)3.74432520
51glomerular basement membrane development (GO:0032836)3.73605370
52midbrain development (GO:0030901)3.72474905
53desmosome organization (GO:0002934)3.72355041
54cochlea morphogenesis (GO:0090103)3.70790087
55Notch signaling involved in heart development (GO:0061314)3.66099279
56dopaminergic neuron differentiation (GO:0071542)3.64110930
57negative regulation of epidermis development (GO:0045683)3.59111925
58glomerular epithelial cell development (GO:0072310)3.57345501
59endocardial cushion morphogenesis (GO:0003203)3.56802583
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53001784
61convergent extension (GO:0060026)3.52046248
62negative regulation of epidermal cell differentiation (GO:0045605)3.50853044
63radial glial cell differentiation (GO:0060019)3.44682178
64branching involved in salivary gland morphogenesis (GO:0060445)3.43438760
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.43007254
66embryonic foregut morphogenesis (GO:0048617)3.42555794
67non-canonical Wnt signaling pathway (GO:0035567)3.40211691
68establishment of nucleus localization (GO:0040023)3.34288639
69negative regulation of T cell differentiation in thymus (GO:0033085)3.33340996
70ectoderm development (GO:0007398)3.32471421
71regulation of oligodendrocyte differentiation (GO:0048713)3.32278650
72regulation of axon guidance (GO:1902667)3.31812311
73negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.31621430
74pituitary gland development (GO:0021983)3.29827280
75neuron cell-cell adhesion (GO:0007158)3.29534817
76mesenchyme morphogenesis (GO:0072132)3.29069758
77notochord development (GO:0030903)3.28285927
78negative regulation of telomerase activity (GO:0051974)3.27824330
79regulation of establishment of planar polarity (GO:0090175)3.27729540
80axonemal dynein complex assembly (GO:0070286)3.26870148
81positive regulation of oligodendrocyte differentiation (GO:0048714)3.25576997
82hemidesmosome assembly (GO:0031581)3.24850058
83heterochromatin organization (GO:0070828)3.22264455
84ribosomal small subunit assembly (GO:0000028)3.22176849
85negative regulation of embryonic development (GO:0045992)3.21662798
86renal system development (GO:0072001)3.21648536
87negative regulation of astrocyte differentiation (GO:0048712)3.20103117
88mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.18530976
89intermediate filament organization (GO:0045109)3.18404302
90epithelial cell fate commitment (GO:0072148)3.18315394
91cell-cell signaling involved in cell fate commitment (GO:0045168)3.14544836
92negative chemotaxis (GO:0050919)3.14500411
93regulation of telomere maintenance via telomerase (GO:0032210)3.14077016
94heart valve formation (GO:0003188)3.13520180
95maturation of SSU-rRNA (GO:0030490)3.12974854
96negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.12033543
97negative regulation of DNA-templated transcription, elongation (GO:0032785)3.12033543
98DNA damage induced protein phosphorylation (GO:0006975)3.11355190
99positive regulation of gastrulation (GO:2000543)3.10853380
100positive regulation of embryonic development (GO:0040019)3.09411755
101molting cycle (GO:0042303)3.09350491
102hair cycle (GO:0042633)3.09350491
103translational elongation (GO:0006414)3.07771625
104cell proliferation involved in metanephros development (GO:0072203)3.06273931
105somatic stem cell division (GO:0048103)3.06155284
106nonmotile primary cilium assembly (GO:0035058)3.05960812
107epithelial cilium movement (GO:0003351)3.05722050
108heart trabecula morphogenesis (GO:0061384)3.05130186
109spinal cord development (GO:0021510)3.04988102
110apical protein localization (GO:0045176)3.04704050
111positive regulation of BMP signaling pathway (GO:0030513)3.03966314
112developmental induction (GO:0031128)3.02309431
113positive regulation of neuroblast proliferation (GO:0002052)3.02296298
114cellular protein complex disassembly (GO:0043624)3.01995236
115negative regulation of B cell mediated immunity (GO:0002713)3.01398155
116negative regulation of immunoglobulin mediated immune response (GO:0002890)3.01398155
117cilium movement (GO:0003341)2.99008333
118negative regulation of axon extension (GO:0030517)2.98851612
119nucleobase catabolic process (GO:0046113)2.98161657
120neuroblast proliferation (GO:0007405)2.97871530
121axonal fasciculation (GO:0007413)2.97783166
122cerebral cortex radially oriented cell migration (GO:0021799)2.97210206
123positive regulation of tolerance induction (GO:0002645)2.96251335
124inner ear receptor cell development (GO:0060119)2.95922656
125thalamus development (GO:0021794)2.94728499
126cellular response to cholesterol (GO:0071397)2.94670949
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93126675
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92913914
129cotranslational protein targeting to membrane (GO:0006613)2.92764297
130camera-type eye morphogenesis (GO:0048593)2.92671659
131innervation (GO:0060384)2.91626446
132intraciliary transport (GO:0042073)2.91437412
133cerebral cortex neuron differentiation (GO:0021895)2.90736694
134negative regulation of glial cell differentiation (GO:0045686)2.90680044
135regulation of non-canonical Wnt signaling pathway (GO:2000050)2.89409486
136viral life cycle (GO:0019058)2.88590862
137negative regulation of smoothened signaling pathway (GO:0045879)2.87992193
138cranial nerve development (GO:0021545)2.87458797
139protein complex disassembly (GO:0043241)2.87252922
140neuron recognition (GO:0008038)2.86414922
141* hair follicle development (GO:0001942)2.86362182
142regulation of chemokine-mediated signaling pathway (GO:0070099)2.86148204
143protein targeting to ER (GO:0045047)2.86047263
144ribosomal small subunit biogenesis (GO:0042274)2.85806940
145mesenchymal cell proliferation (GO:0010463)2.85489309
146somite development (GO:0061053)2.84919137
147chondrocyte development (GO:0002063)2.83969324
148regulation of development, heterochronic (GO:0040034)2.79922100
149establishment or maintenance of apical/basal cell polarity (GO:0035088)2.79647268
150establishment or maintenance of bipolar cell polarity (GO:0061245)2.79647268
151lung lobe morphogenesis (GO:0060463)2.77811840
152regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.77395487
153ventricular trabecula myocardium morphogenesis (GO:0003222)2.75650874
154regulation of helicase activity (GO:0051095)2.75487838
155* hair cycle process (GO:0022405)2.74967722
156* molting cycle process (GO:0022404)2.74967722
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74479930
158primitive streak formation (GO:0090009)2.73635041
159artery development (GO:0060840)2.73159420
160pattern specification involved in kidney development (GO:0061004)2.72668345
161cell migration in hindbrain (GO:0021535)2.71900150
162positive regulation of Notch signaling pathway (GO:0045747)2.71389562
163olfactory bulb development (GO:0021772)2.71363691
164proximal/distal pattern formation (GO:0009954)2.70049660
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68177440
166macromolecular complex disassembly (GO:0032984)2.64429863
167negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61122431
168negative regulation of telomere maintenance (GO:0032205)2.60889686
169protein localization to endoplasmic reticulum (GO:0070972)2.59216130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.90558199
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.11452104
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.07845286
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00527956
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69057673
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54048680
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39528400
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39528400
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39528400
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.36217723
11EZH2_22144423_ChIP-Seq_EOC_Human2.34924703
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33371689
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32244489
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30234084
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.27016002
16* TP53_20018659_ChIP-ChIP_R1E_Mouse2.23252284
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.17769672
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17199890
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13336032
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.13256888
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09399750
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08198810
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.07038655
24* ERG_21242973_ChIP-ChIP_JURKAT_Human2.04576503
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03102169
26* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03102169
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01531475
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00489042
29E2F7_22180533_ChIP-Seq_HELA_Human1.99486160
30* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97197297
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91172719
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.90092111
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81223517
34GBX2_23144817_ChIP-Seq_PC3_Human1.79371090
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78728805
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76113014
37* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75896371
38* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74209249
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.73285803
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69450315
41* RING1B_27294783_Chip-Seq_NPCs_Mouse1.69394472
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67097361
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64181332
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61882727
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61326148
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.60880190
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.58878727
48* CBX2_27304074_Chip-Seq_ESCs_Mouse1.55946821
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.55374008
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.54958640
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54773212
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54636857
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54182102
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54182102
55* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51228550
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51042058
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.50439931
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50313123
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48822939
60* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46796928
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46623604
62* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46102413
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45775935
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44379469
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44160214
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42750946
67* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41455527
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41100986
69* TRIM28_21343339_ChIP-Seq_HEK293_Human1.40450858
70FUS_26573619_Chip-Seq_HEK293_Human1.39909868
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38543624
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37800805
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37465553
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35060004
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34943282
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.32963983
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31659251
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29172571
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28580156
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.27008415
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26176581
82EWS_26573619_Chip-Seq_HEK293_Human1.25830140
83AR_21572438_ChIP-Seq_LNCaP_Human1.25568989
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25070117
85AHR_22903824_ChIP-Seq_MCF-7_Human1.25049880
86TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24509161
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23811806
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22475976
89* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21846999
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20843482
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.18468259
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16243808
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15548331
94P300_19829295_ChIP-Seq_ESCs_Human1.15051962
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12428669
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11696415
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10951687
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.09774342
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.09602871
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09247293
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08671561
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07465188
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06046777
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05796825
105* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05769828
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.04799106
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04455806
108SOX9_26525672_Chip-Seq_HEART_Mouse1.03878809
109SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03203903
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.02623087
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01151010
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.00864845
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00414468
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99614377
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99402165
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.99121194
117* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98658223
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98514240
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97778366
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97608136
121* KDM2B_26808549_Chip-Seq_K562_Human0.97563102
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96767147
123ZNF263_19887448_ChIP-Seq_K562_Human0.94979299
124* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94099970
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92287776
126RNF2_27304074_Chip-Seq_NSC_Mouse0.91525261
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.91245110
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91242225
129* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90382449
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89418787
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.88483414
132KLF5_25053715_ChIP-Seq_YYC3_Human0.88209415
133* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84598030
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83940090
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81626754
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81341700
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81324916
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81052741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.05755071
2MP0000537_abnormal_urethra_morphology3.54782381
3MP0000383_abnormal_hair_follicle3.40767096
4MP0009379_abnormal_foot_pigmentation3.32565503
5MP0010030_abnormal_orbit_morphology3.20765288
6MP0002234_abnormal_pharynx_morphology2.96017030
7MP0009053_abnormal_anal_canal2.90043322
8MP0000467_abnormal_esophagus_morphology2.85483104
9MP0002653_abnormal_ependyma_morphology2.84142055
10MP0000579_abnormal_nail_morphology2.83415239
11MP0003283_abnormal_digestive_organ2.82236987
12MP0003941_abnormal_skin_development2.77699951
13MP0010678_abnormal_skin_adnexa2.75667509
14MP0003880_abnormal_central_pattern2.47277031
15MP0002098_abnormal_vibrissa_morphology2.43571193
16MP0003938_abnormal_ear_development2.33102343
17MP0004381_abnormal_hair_follicle2.32682123
18MP0002249_abnormal_larynx_morphology2.31547777
19MP0002796_impaired_skin_barrier2.29565737
20MP0000049_abnormal_middle_ear2.12606220
21MP0002254_reproductive_system_inflammat2.09965803
22MP0002282_abnormal_trachea_morphology2.07370764
23MP0003136_yellow_coat_color2.05227686
24MP0000762_abnormal_tongue_morphology2.03574899
25MP0006292_abnormal_olfactory_placode2.02585165
26MP0000778_abnormal_nervous_system2.00824086
27MP0008789_abnormal_olfactory_epithelium1.98453892
28MP0002102_abnormal_ear_morphology1.86253731
29MP0003122_maternal_imprinting1.85727731
30MP0001293_anophthalmia1.80706258
31* MP0000647_abnormal_sebaceous_gland1.76634140
32MP0005394_taste/olfaction_phenotype1.76113506
33MP0005499_abnormal_olfactory_system1.76113506
34MP0003755_abnormal_palate_morphology1.64628924
35MP0001346_abnormal_lacrimal_gland1.62858705
36MP0000428_abnormal_craniofacial_morphol1.61762512
37MP0001529_abnormal_vocalization1.60554512
38MP0004133_heterotaxia1.59649316
39MP0010234_abnormal_vibrissa_follicle1.59222623
40MP0003315_abnormal_perineum_morphology1.56953774
41MP0003942_abnormal_urinary_system1.55091400
42MP0003937_abnormal_limbs/digits/tail_de1.54183036
43MP0002233_abnormal_nose_morphology1.53470227
44MP0000377_abnormal_hair_follicle1.47666321
45MP0002751_abnormal_autonomic_nervous1.47233158
46MP0000026_abnormal_inner_ear1.46941384
47MP0001984_abnormal_olfaction1.45471175
48MP0003119_abnormal_digestive_system1.45427202
49MP0004859_abnormal_synaptic_plasticity1.42736040
50MP0002932_abnormal_joint_morphology1.41680309
51MP0005501_abnormal_skin_physiology1.40692934
52MP0008057_abnormal_DNA_replication1.40241527
53MP0003115_abnormal_respiratory_system1.38281427
54MP0002092_abnormal_eye_morphology1.36904844
55MP0002116_abnormal_craniofacial_bone1.33586912
56MP0005248_abnormal_Harderian_gland1.32102032
57MP0005076_abnormal_cell_differentiation1.31613788
58MP0003890_abnormal_embryonic-extraembry1.29157413
59MP0002822_catalepsy1.24952896
60MP0002009_preneoplasia1.24758052
61MP0003861_abnormal_nervous_system1.23037539
62MP0003121_genomic_imprinting1.22755913
63MP0003453_abnormal_keratinocyte_physiol1.20049316
64MP0002277_abnormal_respiratory_mucosa1.18497562
65MP0004270_analgesia1.16840768
66MP0002697_abnormal_eye_size1.16679063
67MP0001286_abnormal_eye_development1.16581428
68MP0000432_abnormal_head_morphology1.16473947
69MP0000462_abnormal_digestive_system1.15688317
70MP0002111_abnormal_tail_morphology1.11921144
71MP0009250_abnormal_appendicular_skeleto1.11640198
72MP0004858_abnormal_nervous_system1.11189326
73MP0000631_abnormal_neuroendocrine_gland1.11183964
74* MP0001216_abnormal_epidermal_layer1.10615147
75MP0005171_absent_coat_pigmentation1.08052632
76MP0001340_abnormal_eyelid_morphology1.06750378
77MP0003935_abnormal_craniofacial_develop1.06595915
78MP0000534_abnormal_ureter_morphology1.06085877
79MP0002084_abnormal_developmental_patter1.05321000
80MP0002734_abnormal_mechanical_nocicepti1.04899180
81MP0003635_abnormal_synaptic_transmissio1.04384793
82MP0010771_integument_phenotype1.03865970
83MP0002063_abnormal_learning/memory/cond1.01738998
84MP0006276_abnormal_autonomic_nervous1.00865908
85MP0000613_abnormal_salivary_gland1.00812911
86MP0005508_abnormal_skeleton_morphology0.99644913
87MP0002557_abnormal_social/conspecific_i0.99238799
88MP0002085_abnormal_embryonic_tissue0.98015132
89MP0001486_abnormal_startle_reflex0.95521541
90MP0002638_abnormal_pupillary_reflex0.95139070
91MP0002736_abnormal_nociception_after0.94554819
92MP0005195_abnormal_posterior_eye0.94458438
93MP0002060_abnormal_skin_morphology0.94005788
94MP0009745_abnormal_behavioral_response0.93189150
95MP0004885_abnormal_endolymph0.93096249
96MP0001963_abnormal_hearing_physiology0.92559254
97MP0002752_abnormal_somatic_nervous0.92316545
98MP0002882_abnormal_neuron_morphology0.91934715
99MP0005423_abnormal_somatic_nervous0.91846310
100MP0002064_seizures0.91679527
101MP0000427_abnormal_hair_cycle0.91440098
102MP0005275_abnormal_skin_tensile0.89696563
103MP0002938_white_spotting0.89109995
104MP0001849_ear_inflammation0.88314496
105MP0006072_abnormal_retinal_apoptosis0.88133296
106MP0008932_abnormal_embryonic_tissue0.88018856
107MP0002184_abnormal_innervation0.87496556
108MP0009672_abnormal_birth_weight0.87295502
109MP0004142_abnormal_muscle_tone0.86537261
110MP0002572_abnormal_emotion/affect_behav0.84377504
111MP0003787_abnormal_imprinting0.81503706
112MP0003878_abnormal_ear_physiology0.81433520
113MP0005377_hearing/vestibular/ear_phenot0.81433520
114MP0001485_abnormal_pinna_reflex0.80161150
115MP0005646_abnormal_pituitary_gland0.78969759
116MP0004197_abnormal_fetal_growth/weight/0.78854761
117MP0003385_abnormal_body_wall0.78768082
118MP0002177_abnormal_outer_ear0.77731699
119MP0003705_abnormal_hypodermis_morpholog0.77602269
120MP0004811_abnormal_neuron_physiology0.77433063
121MP0002272_abnormal_nervous_system0.75115185
122MP0005391_vision/eye_phenotype0.74892816
123MP0001968_abnormal_touch/_nociception0.74837759
124MP0003111_abnormal_nucleus_morphology0.73763211
125MP0003567_abnormal_fetal_cardiomyocyte0.73025045
126MP0001299_abnormal_eye_distance/0.71907771
127MP0000955_abnormal_spinal_cord0.71208429
128MP0004742_abnormal_vestibular_system0.70119576
129MP0003123_paternal_imprinting0.69844962
130MP0005187_abnormal_penis_morphology0.69713745
131MP0009384_cardiac_valve_regurgitation0.69671876
132MP0002081_perinatal_lethality0.69209084
133MP0002152_abnormal_brain_morphology0.67636525
134MP0002109_abnormal_limb_morphology0.65666664
135MP0000350_abnormal_cell_proliferation0.64980568
136MP0000163_abnormal_cartilage_morphology0.64966110
137MP0005257_abnormal_intraocular_pressure0.63900180
138MP0004272_abnormal_basement_membrane0.62612046

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.03794262
2Maternal diabetes (HP:0009800)3.73732987
3Hypotrichosis (HP:0001006)3.62537980
4Bilateral microphthalmos (HP:0007633)3.52419281
5Septo-optic dysplasia (HP:0100842)3.47697860
6Oligodactyly (hands) (HP:0001180)3.46949097
7Fragile nails (HP:0001808)3.46885421
8Anophthalmia (HP:0000528)3.46041467
9Oligodactyly (HP:0012165)3.26464371
10Abnormal number of incisors (HP:0011064)3.25113770
11Onycholysis (HP:0001806)3.24432673
12Woolly hair (HP:0002224)3.18795749
13Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.10500117
14Abnormality of the diencephalon (HP:0010662)3.07205759
15Abnormality of the 4th metacarpal (HP:0010012)3.05699895
16Aplasia cutis congenita (HP:0001057)3.01819942
17Milia (HP:0001056)2.97528987
18Esophageal atresia (HP:0002032)2.92018677
19Reticulocytopenia (HP:0001896)2.91392092
20Coronal craniosynostosis (HP:0004440)2.90558295
21Down-sloping shoulders (HP:0200021)2.89544673
22Split foot (HP:0001839)2.82293845
23Aplasia involving bones of the upper limbs (HP:0009823)2.73026693
24Aplasia of the phalanges of the hand (HP:0009802)2.73026693
25Aplasia involving bones of the extremities (HP:0009825)2.73026693
26Natal tooth (HP:0000695)2.71820087
27Megalencephaly (HP:0001355)2.68424463
28Colon cancer (HP:0003003)2.52929698
29Ridged nail (HP:0001807)2.52783258
30Humeroradial synostosis (HP:0003041)2.52691321
31Synostosis involving the elbow (HP:0003938)2.52691321
32Bronchomalacia (HP:0002780)2.50414157
33Duplication of thumb phalanx (HP:0009942)2.49581539
34Synostosis of carpal bones (HP:0005048)2.45766062
35True hermaphroditism (HP:0010459)2.44805767
36Missing ribs (HP:0000921)2.43669817
37Plantar hyperkeratosis (HP:0007556)2.39060869
38Absent septum pellucidum (HP:0001331)2.38848418
39Supernumerary ribs (HP:0005815)2.37431584
40Hepatoblastoma (HP:0002884)2.35932254
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.35783043
42Nephronophthisis (HP:0000090)2.35407353
43Intestinal atresia (HP:0011100)2.35136115
44Pterygium (HP:0001059)2.33191902
45Nail dystrophy (HP:0008404)2.32862657
46Adactyly (HP:0009776)2.32532065
47Broad thumb (HP:0011304)2.32355757
48High anterior hairline (HP:0009890)2.32301795
49Abnormal respiratory epithelium morphology (HP:0012253)2.31472632
50Abnormal respiratory motile cilium morphology (HP:0005938)2.31472632
51Preaxial foot polydactyly (HP:0001841)2.30243492
52Turricephaly (HP:0000262)2.27403543
53Cutaneous finger syndactyly (HP:0010554)2.26209309
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25453785
55Sclerocornea (HP:0000647)2.25430018
56Abnormality of the middle phalanges of the toes (HP:0010183)2.24864498
57Aplasia involving forearm bones (HP:0009822)2.23895637
58Absent forearm bone (HP:0003953)2.23895637
59Abnormal ciliary motility (HP:0012262)2.23506859
60Chin dimple (HP:0010751)2.22397301
61Cutaneous syndactyly (HP:0012725)2.22216046
62Sparse scalp hair (HP:0002209)2.21940816
63Abnormal respiratory motile cilium physiology (HP:0012261)2.21698835
64Supernumerary bones of the axial skeleton (HP:0009144)2.20839573
65Abnormality of the aortic arch (HP:0012303)2.20247709
66Renal dysplasia (HP:0000110)2.19619801
67Trigonocephaly (HP:0000243)2.18780994
68Partial duplication of thumb phalanx (HP:0009944)2.18772249
69Ankyloglossia (HP:0010296)2.17407510
70Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.17239355
71Vertebral clefting (HP:0008428)2.16616430
72Short middle phalanx of the 5th finger (HP:0004220)2.16400547
73Abnormality of midbrain morphology (HP:0002418)2.16231626
74Molar tooth sign on MRI (HP:0002419)2.16231626
75Abnormality of nail color (HP:0100643)2.13837233
76Hemivertebrae (HP:0002937)2.13830975
77Morphological abnormality of the middle ear (HP:0008609)2.11632685
78Hypoplastic labia majora (HP:0000059)2.11323958
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11274000
80Short 4th metacarpal (HP:0010044)2.11274000
81Holoprosencephaly (HP:0001360)2.10101407
82Broad finger (HP:0001500)2.10064739
83Abnormality of the septum pellucidum (HP:0007375)2.10025996
84Bifid scrotum (HP:0000048)2.09636549
85Carpal synostosis (HP:0009702)2.09127188
86Fibular hypoplasia (HP:0003038)2.08639218
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07727386
88Vertebral hypoplasia (HP:0008417)2.07727386
89Broad phalanges of the hand (HP:0009768)2.07149797
90Abnormality of the labia minora (HP:0012880)2.06062419
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05268195
92Morphological abnormality of the inner ear (HP:0011390)2.04377906
93Amelogenesis imperfecta (HP:0000705)2.02523788
94Congenital, generalized hypertrichosis (HP:0004540)2.01376233
95Focal motor seizures (HP:0011153)2.01036388
96Tarsal synostosis (HP:0008368)1.99603394
97Pancreatic fibrosis (HP:0100732)1.99213690
98Synostosis involving bones of the feet (HP:0009140)1.99142706
99Synostosis involving bones of the lower limbs (HP:0009138)1.99142706
100Alacrima (HP:0000522)1.98619585
101Rib fusion (HP:0000902)1.97536251
102Aqueductal stenosis (HP:0002410)1.97406824
103Abnormality of the antihelix (HP:0009738)1.97377589
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96365748
105Vitreoretinal degeneration (HP:0000655)1.96287875
106Partial duplication of the phalanx of hand (HP:0009999)1.95441907
107Renal hypoplasia (HP:0000089)1.94921626
108Abnormality of chromosome segregation (HP:0002916)1.94370702
109Lip pit (HP:0100267)1.94350637
110Selective tooth agenesis (HP:0001592)1.94006381
11111 pairs of ribs (HP:0000878)1.93953792
112Labial hypoplasia (HP:0000066)1.93644723
113Postaxial foot polydactyly (HP:0001830)1.92795815
114Gastrointestinal atresia (HP:0002589)1.92607807
115Aplasia/Hypoplasia of the clavicles (HP:0006710)1.92505725
116Rectal fistula (HP:0100590)1.92324979
117Rectovaginal fistula (HP:0000143)1.92324979
118Broad phalanx (HP:0006009)1.91778656
119Abnormality of the renal medulla (HP:0100957)1.90428292
120Mixed hearing impairment (HP:0000410)1.90417458
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.90041622
122Absent radius (HP:0003974)1.89758275
123Abnormality of the labia majora (HP:0012881)1.89694278
124Advanced eruption of teeth (HP:0006288)1.88454909
125Preaxial hand polydactyly (HP:0001177)1.88190318
126Broad metatarsal (HP:0001783)1.87559492
127Abnormality of the incisor (HP:0000676)1.87023271
128Abnormality of cells of the erythroid lineage (HP:0012130)1.86110786
129Anonychia (HP:0001798)1.86105251
130Abnormality of the upper arm (HP:0001454)1.85884354
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.85319845
132Absent/shortened dynein arms (HP:0200106)1.85319845
133Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85212603
1342-3 toe syndactyly (HP:0004691)1.84583927
135Abnormality of the axillary hair (HP:0100134)1.83927358
136Abnormality of secondary sexual hair (HP:0009888)1.83927358
137Pili torti (HP:0003777)1.83300162
138Patellar aplasia (HP:0006443)1.82064072
139Sex reversal (HP:0012245)1.82053383
140Abnormal sex determination (HP:0012244)1.82053383
141Choanal stenosis (HP:0000452)1.81701382
142Postaxial hand polydactyly (HP:0001162)1.79781132
143Palmar hyperkeratosis (HP:0010765)1.79010985
144Atrophic scars (HP:0001075)1.78997593
145Synostosis involving bones of the hand (HP:0004278)1.77832247
146Broad distal phalanx of finger (HP:0009836)1.77280141
147Triphalangeal thumb (HP:0001199)1.77156700
148Broad long bones (HP:0005622)1.76342182
149Pancreatic cysts (HP:0001737)1.76311516
150Abnormality of the intervertebral disk (HP:0005108)1.75573866
151Hypoplasia of the ulna (HP:0003022)1.75564435
152Optic nerve hypoplasia (HP:0000609)1.74107419
153Split hand (HP:0001171)1.74096342
154Anencephaly (HP:0002323)1.73467536
155Spastic diplegia (HP:0001264)1.73317299
156Hypoplastic female external genitalia (HP:0012815)1.72807111
157Aplasia/Hypoplasia of the patella (HP:0006498)1.72535748
158Abnormality of the labia (HP:0000058)1.70687891
159Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70486579
160Palmoplantar hyperkeratosis (HP:0000972)1.69662234
161Stenosis of the external auditory canal (HP:0000402)1.69283101
162Hypohidrosis (HP:0000966)1.69194699
163Growth hormone deficiency (HP:0000824)1.68837987
164Prenatal maternal abnormality (HP:0002686)1.67894119
165Fibular aplasia (HP:0002990)1.67860162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.79004554
2KSR14.85753889
3TAOK23.55009322
4SIK33.14150041
5NTRK22.98122022
6BCR2.64306988
7ERBB22.21936219
8MAP3K102.09377134
9TLK12.09339213
10DDR22.03667587
11TYRO32.01126939
12DYRK31.97649430
13ICK1.96309925
14CDK191.91982553
15TAF11.89708488
16VRK21.89593080
17LATS11.78722415
18SIK11.73245494
19EPHA21.72734369
20FGFR21.64199058
21MAP2K61.57782458
22WNK31.55502962
23NTRK11.54117802
24CAMK1D1.50954677
25CAMK1G1.50515043
26TNIK1.44719486
27WNK41.38427366
28NTRK31.37293184
29DYRK1B1.37278590
30FER1.36874385
31MARK11.36190793
32MAP3K41.34562644
33UHMK11.28315704
34MKNK11.25683714
35VRK11.25683463
36PDGFRA1.25035836
37LATS21.24209980
38ERBB31.23603084
39ERBB41.16884118
40NME11.14108727
41WEE11.13346367
42BUB11.12279153
43SRPK11.11829778
44MST1R1.09644448
45PIK3CA1.09349847
46MKNK21.08988824
47SIK21.08961642
48CDK71.07382076
49LMTK21.05412932
50MAPKAPK31.03356126
51FGFR10.99964849
52MAP2K70.99480115
53NUAK10.96462850
54STK390.95670774
55CDK60.95047987
56BRSK20.93391028
57PRKD30.91695601
58EPHA40.90712131
59IRAK20.89842158
60CASK0.89145799
61IRAK10.85560604
62DYRK20.83807151
63MST40.83744350
64PRKCG0.83276470
65TTK0.82146572
66EPHA30.80812976
67DMPK0.80755130
68RPS6KB20.79201254
69CDK180.79162401
70NEK60.77551176
71PLK10.77411770
72MAPK150.76128794
73MAP3K90.75936564
74PLK20.75484111
75TGFBR10.75350334
76PLK40.72129949
77AURKA0.72035238
78AURKB0.71025096
79MAP4K20.70979980
80MATK0.70350452
81PHKG10.68658003
82PHKG20.68658003
83CDK11A0.68419282
84AKT20.65384260
85PTK60.65204296
86CSNK1G20.64473547
87CSNK1G10.64274939
88ROCK20.64037294
89TRIB30.63253783
90PRKCI0.62673284
91EEF2K0.62452300
92MTOR0.62294693
93CSNK1A1L0.62071187
94CHUK0.61809362
95CDC70.61702027
96NEK20.61237091
97CDK150.59918643
98MINK10.59657449
99FGR0.59581665
100MAPKAPK50.58468187
101MAP3K50.58369288
102CHEK20.58267254
103STK110.58176501
104MELK0.57959006
105RPS6KA10.56416906
106MET0.56116018
107YES10.55454411
108CDK140.54049582
109CDK30.53876964
110PAK40.53758273
111NLK0.53478062
112BRSK10.50864032
113CHEK10.50297699
114PAK30.48240411
115ATR0.48067914
116PNCK0.47899179
117STK30.47774794
118CSNK1G30.47750380
119MAP2K40.47465097
120BMX0.46623129
121STK240.44873598
122CSNK1E0.43891805
123CDK10.43754081
124CDK20.43724878
125MAPK130.42939891
126CDK120.42381405
127PASK0.42286830
128PLK30.42134132
129PAK60.41852236
130SGK4940.41824665
131SGK2230.41824665
132CSNK1D0.41244463
133WNK10.41219926
134DYRK1A0.40901293
135NEK10.40874458
136MAPK90.39098181
137TSSK60.38822985
138CAMK10.38549597
139SRC0.37045761
140ROCK10.36696684
141CDK40.35578466
142MAP3K70.34749356
143CDK50.34355705
144BMPR1B0.34324345
145PRKDC0.33844138
146ZAK0.33523369
147PKN10.32535613
148ADRBK20.31907758
149ATM0.31736465

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.38253472
2Hedgehog signaling pathway_Homo sapiens_hsa043404.18577423
3Notch signaling pathway_Homo sapiens_hsa043303.74596697
4Hippo signaling pathway_Homo sapiens_hsa043903.32643184
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.85291629
6Axon guidance_Homo sapiens_hsa043602.59221339
7Wnt signaling pathway_Homo sapiens_hsa043102.49167691
8Nitrogen metabolism_Homo sapiens_hsa009102.28080640
9Melanogenesis_Homo sapiens_hsa049162.18526594
10Dorso-ventral axis formation_Homo sapiens_hsa043202.14407352
11MicroRNAs in cancer_Homo sapiens_hsa052062.09303251
12Spliceosome_Homo sapiens_hsa030401.88623900
13Cardiac muscle contraction_Homo sapiens_hsa042601.81207491
14Cell cycle_Homo sapiens_hsa041101.67473553
15Bladder cancer_Homo sapiens_hsa052191.63091461
16Oxidative phosphorylation_Homo sapiens_hsa001901.60176382
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59257629
18Adherens junction_Homo sapiens_hsa045201.56517205
19Huntingtons disease_Homo sapiens_hsa050161.55449863
20Vitamin B6 metabolism_Homo sapiens_hsa007501.52172023
21Proteoglycans in cancer_Homo sapiens_hsa052051.44372041
22Parkinsons disease_Homo sapiens_hsa050121.42528719
23TGF-beta signaling pathway_Homo sapiens_hsa043501.41725959
24mRNA surveillance pathway_Homo sapiens_hsa030151.41350760
25DNA replication_Homo sapiens_hsa030301.38753706
26Ribosome_Homo sapiens_hsa030101.33665598
27Tight junction_Homo sapiens_hsa045301.31355427
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28737671
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27924237
30p53 signaling pathway_Homo sapiens_hsa041151.27404990
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25013145
32Endometrial cancer_Homo sapiens_hsa052131.23664209
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22047259
34Glioma_Homo sapiens_hsa052141.21501550
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20488360
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17240809
37Pathways in cancer_Homo sapiens_hsa052001.16530724
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13601064
39Fatty acid biosynthesis_Homo sapiens_hsa000611.11077270
40ErbB signaling pathway_Homo sapiens_hsa040121.10312386
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07385386
42RNA transport_Homo sapiens_hsa030131.06316718
43Alzheimers disease_Homo sapiens_hsa050101.05319468
44Oocyte meiosis_Homo sapiens_hsa041141.01248162
45Phototransduction_Homo sapiens_hsa047441.00538174
46Small cell lung cancer_Homo sapiens_hsa052220.99948986
47HTLV-I infection_Homo sapiens_hsa051660.99400762
48Steroid biosynthesis_Homo sapiens_hsa001000.98663969
49GABAergic synapse_Homo sapiens_hsa047270.98210162
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97668465
51Taste transduction_Homo sapiens_hsa047420.97462789
52Colorectal cancer_Homo sapiens_hsa052100.94509771
53Base excision repair_Homo sapiens_hsa034100.93840464
54Sulfur relay system_Homo sapiens_hsa041220.92710216
55Chronic myeloid leukemia_Homo sapiens_hsa052200.92278338
56Melanoma_Homo sapiens_hsa052180.91219777
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90112649
58Renal cell carcinoma_Homo sapiens_hsa052110.88388987
59Prostate cancer_Homo sapiens_hsa052150.88355138
60ECM-receptor interaction_Homo sapiens_hsa045120.86526223
61beta-Alanine metabolism_Homo sapiens_hsa004100.85602370
62Circadian entrainment_Homo sapiens_hsa047130.84563286
63Butanoate metabolism_Homo sapiens_hsa006500.83828590
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83439904
65Basal transcription factors_Homo sapiens_hsa030220.83331012
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82911963
67Selenocompound metabolism_Homo sapiens_hsa004500.81821105
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81770809
69Gap junction_Homo sapiens_hsa045400.80686377
70Morphine addiction_Homo sapiens_hsa050320.75954378
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75366044
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75138820
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.74620067
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74395736
75Choline metabolism in cancer_Homo sapiens_hsa052310.73897267
76RNA polymerase_Homo sapiens_hsa030200.73217864
77Dopaminergic synapse_Homo sapiens_hsa047280.72916617
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71677114
79cAMP signaling pathway_Homo sapiens_hsa040240.71490316
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71347003
81Focal adhesion_Homo sapiens_hsa045100.71300176
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70475329
83Non-small cell lung cancer_Homo sapiens_hsa052230.69398614
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66461224
85mTOR signaling pathway_Homo sapiens_hsa041500.66319386
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66284391
87Lysine degradation_Homo sapiens_hsa003100.64249847
88Folate biosynthesis_Homo sapiens_hsa007900.63562515
89Circadian rhythm_Homo sapiens_hsa047100.62120952
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61934841
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61808712
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.60807651
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59712479
94Estrogen signaling pathway_Homo sapiens_hsa049150.59536048
95Rap1 signaling pathway_Homo sapiens_hsa040150.59074453
96VEGF signaling pathway_Homo sapiens_hsa043700.58856938
97Dilated cardiomyopathy_Homo sapiens_hsa054140.58471672
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57764664
99Mismatch repair_Homo sapiens_hsa034300.57008346
100Nicotine addiction_Homo sapiens_hsa050330.56989624
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56463117
102Gastric acid secretion_Homo sapiens_hsa049710.55581070
103Insulin secretion_Homo sapiens_hsa049110.55357193
104Mineral absorption_Homo sapiens_hsa049780.54801909
105Retinol metabolism_Homo sapiens_hsa008300.54680689
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54454468
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54202012
108Fanconi anemia pathway_Homo sapiens_hsa034600.54090574
109Olfactory transduction_Homo sapiens_hsa047400.53753105
110Histidine metabolism_Homo sapiens_hsa003400.52938646
111GnRH signaling pathway_Homo sapiens_hsa049120.50449326
112Oxytocin signaling pathway_Homo sapiens_hsa049210.50259617
113Alcoholism_Homo sapiens_hsa050340.49540926
114Linoleic acid metabolism_Homo sapiens_hsa005910.49435483
115Glutathione metabolism_Homo sapiens_hsa004800.49246372
116Homologous recombination_Homo sapiens_hsa034400.49120382
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48324052
118Ras signaling pathway_Homo sapiens_hsa040140.47504926
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46854303
120Long-term depression_Homo sapiens_hsa047300.46663457
121Amphetamine addiction_Homo sapiens_hsa050310.44923329
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.44554570
123Cholinergic synapse_Homo sapiens_hsa047250.44535005
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44500681
125Ether lipid metabolism_Homo sapiens_hsa005650.44407513
126Glutamatergic synapse_Homo sapiens_hsa047240.43881722
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.43819085
128RNA degradation_Homo sapiens_hsa030180.43280022
129Thyroid cancer_Homo sapiens_hsa052160.42103959
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40571155
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36818950
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36637539
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.35855450
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34588119
135Pyrimidine metabolism_Homo sapiens_hsa002400.33320710
136Chemical carcinogenesis_Homo sapiens_hsa052040.32031672
137Prion diseases_Homo sapiens_hsa050200.31990465
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31254958
139Cocaine addiction_Homo sapiens_hsa050300.30386376
140Nucleotide excision repair_Homo sapiens_hsa034200.29710524
141Pancreatic cancer_Homo sapiens_hsa052120.28909331
142FoxO signaling pathway_Homo sapiens_hsa040680.28047194
143Salivary secretion_Homo sapiens_hsa049700.25737781
144AMPK signaling pathway_Homo sapiens_hsa041520.25026889
145Insulin signaling pathway_Homo sapiens_hsa049100.24948770
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22855421

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