SOX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)6.32741910
2paraxial mesoderm development (GO:0048339)5.68226528
3planar cell polarity pathway involved in neural tube closure (GO:0090179)5.21943625
4neuron fate determination (GO:0048664)4.97364517
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.95378897
6pyrimidine nucleobase catabolic process (GO:0006208)4.95343746
7pre-miRNA processing (GO:0031054)4.84693628
8pattern specification involved in kidney development (GO:0061004)4.82550199
9tongue development (GO:0043586)4.70781179
10establishment of planar polarity (GO:0001736)4.51767803
11establishment of tissue polarity (GO:0007164)4.51767803
12viral transcription (GO:0019083)4.40715522
13maturation of SSU-rRNA (GO:0030490)4.39544305
14cerebral cortex radially oriented cell migration (GO:0021799)4.36300593
15translational termination (GO:0006415)4.24666369
16DNA unwinding involved in DNA replication (GO:0006268)4.17076624
17establishment of apical/basal cell polarity (GO:0035089)4.13513415
18somite development (GO:0061053)4.07967160
19ribosomal small subunit assembly (GO:0000028)4.06905222
20radial glial cell differentiation (GO:0060019)4.06880962
21regulation of posttranscriptional gene silencing (GO:0060147)4.02789771
22regulation of gene silencing by miRNA (GO:0060964)4.02789771
23regulation of gene silencing by RNA (GO:0060966)4.02789771
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.00079774
25peptidyl-arginine omega-N-methylation (GO:0035247)3.89298220
26appendage development (GO:0048736)3.86546730
27limb development (GO:0060173)3.86546730
28segment specification (GO:0007379)3.79724917
29nucleobase catabolic process (GO:0046113)3.78638658
30spinal cord development (GO:0021510)3.77852863
31negative regulation of astrocyte differentiation (GO:0048712)3.77709340
32heterochromatin organization (GO:0070828)3.76204974
33negative regulation of oligodendrocyte differentiation (GO:0048715)3.72123919
34neuronal stem cell maintenance (GO:0097150)3.70720830
35ribosomal small subunit biogenesis (GO:0042274)3.70138204
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.65385343
37establishment of monopolar cell polarity (GO:0061162)3.65385343
38L-serine metabolic process (GO:0006563)3.62309661
39nonmotile primary cilium assembly (GO:0035058)3.61667638
40negative regulation of mRNA processing (GO:0050686)3.56395085
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.54495205
42DNA replication-dependent nucleosome assembly (GO:0006335)3.51852647
43DNA replication-dependent nucleosome organization (GO:0034723)3.51852647
44translational elongation (GO:0006414)3.51259846
45peptidyl-arginine methylation (GO:0018216)3.49232790
46peptidyl-arginine N-methylation (GO:0035246)3.49232790
47histone arginine methylation (GO:0034969)3.42850818
48forebrain neuron differentiation (GO:0021879)3.42300103
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.41272107
50negative regulation of RNA splicing (GO:0033119)3.40926195
51axon ensheathment in central nervous system (GO:0032291)3.40847108
52central nervous system myelination (GO:0022010)3.40847108
53cochlea morphogenesis (GO:0090103)3.36679878
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35593575
55retinal ganglion cell axon guidance (GO:0031290)3.34656160
56cardiovascular system development (GO:0072358)3.34043584
57apical protein localization (GO:0045176)3.33305178
58cotranslational protein targeting to membrane (GO:0006613)3.33025478
59regulation of establishment of planar polarity (GO:0090175)3.32957555
60notochord development (GO:0030903)3.32154226
61behavioral response to nicotine (GO:0035095)3.29228508
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29195048
63positive regulation of neuroblast proliferation (GO:0002052)3.28907757
64protein targeting to ER (GO:0045047)3.26927315
65negative regulation of glial cell differentiation (GO:0045686)3.24515927
66protein localization to kinetochore (GO:0034501)3.21676616
67cellular protein complex disassembly (GO:0043624)3.20065502
68viral life cycle (GO:0019058)3.19132080
69postsynaptic membrane organization (GO:0001941)3.17907259
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13258084
71spinal cord association neuron differentiation (GO:0021527)3.13227580
72regulation of timing of cell differentiation (GO:0048505)3.13027818
73presynaptic membrane assembly (GO:0097105)3.12463222
74protein complex disassembly (GO:0043241)3.08645005
75negative regulation of mRNA metabolic process (GO:1903312)3.07736751
76lung-associated mesenchyme development (GO:0060484)3.07601050
77olfactory bulb development (GO:0021772)3.07108172
78positive regulation of oligodendrocyte differentiation (GO:0048714)3.06943117
79regulation of protein heterodimerization activity (GO:0043497)3.05697811
80non-canonical Wnt signaling pathway (GO:0035567)3.03660518
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.03636691
82protein localization to endoplasmic reticulum (GO:0070972)3.02768470
83intraciliary transport (GO:0042073)3.02388940
84convergent extension (GO:0060026)3.01035180
85axonal fasciculation (GO:0007413)3.00725376
86regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.99341046
87establishment or maintenance of apical/basal cell polarity (GO:0035088)2.98022905
88establishment or maintenance of bipolar cell polarity (GO:0061245)2.98022905
89axon extension involved in axon guidance (GO:0048846)2.97806742
90neuron projection extension involved in neuron projection guidance (GO:1902284)2.97806742
91embryonic foregut morphogenesis (GO:0048617)2.97436190
92auditory receptor cell differentiation (GO:0042491)2.96954785
93regulation of sister chromatid cohesion (GO:0007063)2.96718987
94limb bud formation (GO:0060174)2.95548210
95positive regulation of Notch signaling pathway (GO:0045747)2.95476597
96camera-type eye morphogenesis (GO:0048593)2.94631827
97lung epithelium development (GO:0060428)2.92980515
98astrocyte differentiation (GO:0048708)2.92785004
99peptidyl-lysine dimethylation (GO:0018027)2.92531296
100regulation of hippo signaling (GO:0035330)2.92069452
101mitotic sister chromatid segregation (GO:0000070)2.91172070
102macromolecular complex disassembly (GO:0032984)2.90808545
103hippo signaling (GO:0035329)2.88035113
104lens morphogenesis in camera-type eye (GO:0002089)2.87735985
105DNA replication initiation (GO:0006270)2.87210841
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86881297
107substrate-independent telencephalic tangential migration (GO:0021826)2.86201508
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.86201508
109DNA strand elongation involved in DNA replication (GO:0006271)2.84755937
110mRNA splicing, via spliceosome (GO:0000398)2.84249735
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84249735
112sister chromatid segregation (GO:0000819)2.82766441
113positive regulation of neural precursor cell proliferation (GO:2000179)2.82273972
114RNA splicing, via transesterification reactions (GO:0000375)2.81454969
115thalamus development (GO:0021794)2.80704633
116chaperone-mediated protein transport (GO:0072321)2.80345870
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80150629
118spliceosomal snRNP assembly (GO:0000387)2.76726887
119DNA replication checkpoint (GO:0000076)2.75925193
120presynaptic membrane organization (GO:0097090)2.75723719
121* pituitary gland development (GO:0021983)2.74805495
122nephron tubule morphogenesis (GO:0072078)2.73214772
123nephron epithelium morphogenesis (GO:0072088)2.73214772
124chromatin remodeling at centromere (GO:0031055)2.71593099
125cell proliferation in forebrain (GO:0021846)2.71269612
126regulation of neuroblast proliferation (GO:1902692)2.70944224
127spliceosomal complex assembly (GO:0000245)2.70751842
128mitotic chromosome condensation (GO:0007076)2.69855712
129neuron fate commitment (GO:0048663)2.68866791
130negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.68389312
131otic vesicle formation (GO:0030916)2.68303455
132protein-DNA complex disassembly (GO:0032986)2.67543707
133nucleosome disassembly (GO:0006337)2.67543707
134negative regulation of smoothened signaling pathway (GO:0045879)2.67358035
135establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.67291449
136neuron recognition (GO:0008038)2.66827413
137DNA duplex unwinding (GO:0032508)2.65704059
138termination of RNA polymerase II transcription (GO:0006369)2.64976683
139translational initiation (GO:0006413)2.64703078
140nuclear pore organization (GO:0006999)2.64685756
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64469281
142DNA strand elongation (GO:0022616)2.64375860
143dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63884181
144dorsal/ventral pattern formation (GO:0009953)2.63396348
145DNA geometric change (GO:0032392)2.63144979
146smoothened signaling pathway (GO:0007224)2.61413447
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60875987
148negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60875987
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60244915
150glomerular basement membrane development (GO:0032836)2.60034880
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.59238368
152regulation of development, heterochronic (GO:0040034)2.58655050
153protein complex localization (GO:0031503)2.58169563
154protein localization to chromosome, centromeric region (GO:0071459)2.58125909
155mRNA splice site selection (GO:0006376)2.57900531
156outer ear morphogenesis (GO:0042473)2.56760401
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56639691
158chromatin assembly (GO:0031497)2.56609044
159establishment of integrated proviral latency (GO:0075713)2.56288580
160cell surface receptor signaling pathway involved in heart development (GO:0061311)2.54214026
161dendritic spine morphogenesis (GO:0060997)2.53324272
162negative regulation of histone methylation (GO:0031061)2.53193121
163lens fiber cell development (GO:0070307)2.52192460
164neural tube closure (GO:0001843)2.51897503
165negative regulation of gliogenesis (GO:0014014)2.50770566
166histone H4-K12 acetylation (GO:0043983)2.50114686
167establishment of mitochondrion localization (GO:0051654)2.49762237
168regulation of oligodendrocyte differentiation (GO:0048713)2.48995498
169regulation of somitogenesis (GO:0014807)2.47955309
170midbrain development (GO:0030901)2.47397311
171tube closure (GO:0060606)2.47132245
172mitotic nuclear envelope disassembly (GO:0007077)2.46639493
173kinetochore assembly (GO:0051382)2.46497722
174layer formation in cerebral cortex (GO:0021819)2.46066121
175translesion synthesis (GO:0019985)2.45160188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93908640
2EZH2_22144423_ChIP-Seq_EOC_Human5.80936866
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.89120605
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.15197683
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95401156
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.93514658
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91930131
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82823755
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76759163
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69723958
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54465543
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54465543
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54465543
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.24173926
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22509035
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21616978
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21315793
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19411432
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.19117078
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14544089
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12524363
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06867110
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.05177109
24SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03072524
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02380482
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00398872
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.98563500
28XRN2_22483619_ChIP-Seq_HELA_Human1.98085278
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97550639
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96805294
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96082651
32IRF1_19129219_ChIP-ChIP_H3396_Human1.93837447
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.93713597
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93516134
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.92212207
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.90948144
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86407173
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.85236371
39* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83998264
40POU5F1_16518401_ChIP-PET_MESCs_Mouse1.83168395
41* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82697441
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80587980
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78266512
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73764223
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72741069
46MYC_22102868_ChIP-Seq_BL_Human1.71613508
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69746967
48AR_21909140_ChIP-Seq_LNCAP_Human1.66891422
49* EZH2_27294783_Chip-Seq_ESCs_Mouse1.66647393
50* EED_16625203_ChIP-ChIP_MESCs_Mouse1.66104661
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64828084
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62771100
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.61859680
54* E2F1_21310950_ChIP-Seq_MCF-7_Human1.58980227
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.58963511
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58650306
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57602414
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55911136
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54405058
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54042948
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50442774
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50075705
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48614869
64CIITA_25753668_ChIP-Seq_RAJI_Human1.44904540
65* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44491544
66* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44491544
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43841080
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43167653
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43119680
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41799379
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41208799
72* RNF2_27304074_Chip-Seq_NSC_Mouse1.41158177
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41133832
74TTF2_22483619_ChIP-Seq_HELA_Human1.37509703
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35798809
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35651968
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32520634
78REST_21632747_ChIP-Seq_MESCs_Mouse1.31582061
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.31280600
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30763967
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30718384
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30621400
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28384555
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27966880
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26402395
86* ERG_21242973_ChIP-ChIP_JURKAT_Human1.25812010
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24848797
88ZNF274_21170338_ChIP-Seq_K562_Hela1.23853567
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23582386
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23353505
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.22743198
92* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22657576
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22226576
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22172632
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.21805890
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19310827
97MYC_18940864_ChIP-ChIP_HL60_Human1.18893136
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18429188
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17654087
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17654087
101* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17651080
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16672517
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13920136
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13729286
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.13002812
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12498344
107TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12309747
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10359608
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10320041
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.10030173
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09378924
112* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09325813
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09250697
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08632818
115* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07674710
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07148918
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06317140
118VDR_21846776_ChIP-Seq_THP-1_Human1.05057318
119TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05009704
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.04541672
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03965953
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.03823262
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.03472870
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03317942
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02154858
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01342629
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01264466
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00765316
129* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99326363
130* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98890173
131* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98591580
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98285300
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98169738
134* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98064179
135SOX9_26525672_Chip-Seq_HEART_Mouse0.98000720
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97162335
137FUS_26573619_Chip-Seq_HEK293_Human0.97030076
138* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96880501
139CTCF_27219007_Chip-Seq_Bcells_Human0.96794240
140EWS_26573619_Chip-Seq_HEK293_Human0.96606142
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.96123921
142EGR1_19374776_ChIP-ChIP_THP-1_Human0.95738740
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94984741
144KDM5A_27292631_Chip-Seq_BREAST_Human0.94606667
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94435874
146SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93816809
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93490054
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92761993
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.92685940
150KDM2B_26808549_Chip-Seq_DND41_Human0.92186550
151YY1_21170310_ChIP-Seq_MESCs_Mouse0.91672010
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91214483
153IGF1R_20145208_ChIP-Seq_DFB_Human0.90610480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.88199225
2MP0002653_abnormal_ependyma_morphology3.80307478
3MP0010030_abnormal_orbit_morphology3.30629316
4MP0006292_abnormal_olfactory_placode2.78827622
5MP0009053_abnormal_anal_canal2.67330108
6MP0003283_abnormal_digestive_organ2.63712582
7MP0009379_abnormal_foot_pigmentation2.47214511
8MP0003111_abnormal_nucleus_morphology2.30405334
9MP0001293_anophthalmia2.24309634
10MP0002249_abnormal_larynx_morphology2.22298867
11MP0003119_abnormal_digestive_system2.18108641
12MP0005377_hearing/vestibular/ear_phenot2.10845292
13MP0003878_abnormal_ear_physiology2.10845292
14MP0000049_abnormal_middle_ear2.08533943
15MP0004133_heterotaxia2.06768582
16MP0002282_abnormal_trachea_morphology2.06740784
17MP0004957_abnormal_blastocyst_morpholog2.04106341
18MP0008057_abnormal_DNA_replication2.03457800
19MP0005076_abnormal_cell_differentiation1.97122847
20MP0003890_abnormal_embryonic-extraembry1.89234735
21* MP0000778_abnormal_nervous_system1.87690414
22MP0003942_abnormal_urinary_system1.87507409
23MP0003077_abnormal_cell_cycle1.85059848
24MP0004197_abnormal_fetal_growth/weight/1.83815724
25MP0004858_abnormal_nervous_system1.83590368
26MP0003787_abnormal_imprinting1.82610761
27MP0002084_abnormal_developmental_patter1.80138929
28MP0008932_abnormal_embryonic_tissue1.79880487
29MP0010094_abnormal_chromosome_stability1.76639854
30* MP0000428_abnormal_craniofacial_morphol1.76615444
31MP0002085_abnormal_embryonic_tissue1.75862200
32MP0001529_abnormal_vocalization1.73880643
33MP0003861_abnormal_nervous_system1.71264602
34MP0003315_abnormal_perineum_morphology1.70857565
35MP0000566_synostosis1.69426761
36MP0005248_abnormal_Harderian_gland1.66303549
37MP0002092_abnormal_eye_morphology1.63190077
38MP0003937_abnormal_limbs/digits/tail_de1.62847600
39MP0003938_abnormal_ear_development1.62484691
40MP0002697_abnormal_eye_size1.61958653
41MP0003121_genomic_imprinting1.61913176
42MP0008789_abnormal_olfactory_epithelium1.58355809
43MP0003880_abnormal_central_pattern1.58149228
44MP0000467_abnormal_esophagus_morphology1.57523709
45MP0001730_embryonic_growth_arrest1.56763799
46MP0001485_abnormal_pinna_reflex1.56318238
47MP0002932_abnormal_joint_morphology1.55936339
48MP0005499_abnormal_olfactory_system1.55364952
49MP0005394_taste/olfaction_phenotype1.55364952
50MP0000350_abnormal_cell_proliferation1.54327754
51MP0003123_paternal_imprinting1.53569884
52MP0008877_abnormal_DNA_methylation1.50104606
53MP0002234_abnormal_pharynx_morphology1.49618815
54MP0003122_maternal_imprinting1.49577609
55MP0002751_abnormal_autonomic_nervous1.49108826
56MP0003755_abnormal_palate_morphology1.47479927
57MP0003115_abnormal_respiratory_system1.46965161
58MP0002233_abnormal_nose_morphology1.46480221
59MP0002116_abnormal_craniofacial_bone1.44457838
60MP0003136_yellow_coat_color1.44452095
61MP0005380_embryogenesis_phenotype1.41839421
62MP0001672_abnormal_embryogenesis/_devel1.41839421
63MP0002111_abnormal_tail_morphology1.41129524
64MP0003693_abnormal_embryo_hatching1.39863750
65MP0004885_abnormal_endolymph1.36243870
66MP0001697_abnormal_embryo_size1.35923196
67MP0003385_abnormal_body_wall1.33453694
68MP0001984_abnormal_olfaction1.32191547
69MP0008058_abnormal_DNA_repair1.31003702
70MP0000534_abnormal_ureter_morphology1.28740186
71MP0008007_abnormal_cellular_replicative1.26408321
72MP0003935_abnormal_craniofacial_develop1.25732897
73MP0001286_abnormal_eye_development1.25393205
74MP0003984_embryonic_growth_retardation1.22239103
75* MP0000631_abnormal_neuroendocrine_gland1.21385821
76MP0002088_abnormal_embryonic_growth/wei1.20532023
77MP0004233_abnormal_muscle_weight1.15984797
78* MP0000432_abnormal_head_morphology1.13371905
79MP0009278_abnormal_bone_marrow1.11428565
80MP0004859_abnormal_synaptic_plasticity1.10895665
81MP0005195_abnormal_posterior_eye1.09916137
82MP0006276_abnormal_autonomic_nervous1.08812643
83MP0005646_abnormal_pituitary_gland1.08139976
84MP0002080_prenatal_lethality1.07492219
85MP0000383_abnormal_hair_follicle1.07387449
86MP0004142_abnormal_muscle_tone1.06144992
87MP0005391_vision/eye_phenotype1.05401661
88MP0002557_abnormal_social/conspecific_i1.04523124
89MP0002638_abnormal_pupillary_reflex1.04075367
90* MP0002152_abnormal_brain_morphology1.03967393
91MP0002102_abnormal_ear_morphology1.03599909
92MP0002752_abnormal_somatic_nervous1.03590424
93MP0003705_abnormal_hypodermis_morpholog1.00399411
94MP0002114_abnormal_axial_skeleton0.99333548
95MP0003646_muscle_fatigue0.98398168
96MP0001299_abnormal_eye_distance/0.98320118
97MP0002938_white_spotting0.95637132
98MP0002081_perinatal_lethality0.95634971
99MP0000955_abnormal_spinal_cord0.95178582
100MP0001346_abnormal_lacrimal_gland0.94308711
101MP0002086_abnormal_extraembryonic_tissu0.94181356
102MP0002184_abnormal_innervation0.92387957
103MP0003567_abnormal_fetal_cardiomyocyte0.91798916
104MP0009703_decreased_birth_body0.91416088
105MP0000026_abnormal_inner_ear0.90874270
106MP0000733_abnormal_muscle_development0.89815457
107MP0006072_abnormal_retinal_apoptosis0.89677699
108MP0000579_abnormal_nail_morphology0.89488679
109MP0002882_abnormal_neuron_morphology0.89085530
110MP0009250_abnormal_appendicular_skeleto0.88520316
111MP0010678_abnormal_skin_adnexa0.88471292
112MP0000462_abnormal_digestive_system0.87893859
113MP0001963_abnormal_hearing_physiology0.85606719
114MP0002063_abnormal_learning/memory/cond0.84414694
115MP0005623_abnormal_meninges_morphology0.83307556
116MP0005257_abnormal_intraocular_pressure0.82203941
117MP0001915_intracranial_hemorrhage0.82195818
118MP0002736_abnormal_nociception_after0.82070665
119MP0001340_abnormal_eyelid_morphology0.80771091
120MP0001849_ear_inflammation0.80713777
121MP0008961_abnormal_basal_metabolism0.79451770
122MP0009672_abnormal_birth_weight0.78113422
123MP0000647_abnormal_sebaceous_gland0.78029466
124MP0003634_abnormal_glial_cell0.77205067
125MP0000762_abnormal_tongue_morphology0.77123944
126MP0000678_abnormal_parathyroid_gland0.76344525
127MP0002837_dystrophic_cardiac_calcinosis0.75864429
128* MP0002210_abnormal_sex_determination0.75760672
129MP0010352_gastrointestinal_tract_polyps0.73823970
130MP0002572_abnormal_emotion/affect_behav0.73401770
131MP0002163_abnormal_gland_morphology0.72544769
132MP0001486_abnormal_startle_reflex0.72192821
133MP0005551_abnormal_eye_electrophysiolog0.71630479
134MP0004742_abnormal_vestibular_system0.69346538
135MP0003635_abnormal_synaptic_transmissio0.63918320
136MP0005253_abnormal_eye_physiology0.63505001
137MP0005423_abnormal_somatic_nervous0.63466656

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.01820068
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.01820068
3Abnormality of the 4th metacarpal (HP:0010012)3.83187035
4Abnormality of the labia minora (HP:0012880)3.63559722
5Rib fusion (HP:0000902)3.62802368
6Abnormal number of incisors (HP:0011064)3.58774536
7Reticulocytopenia (HP:0001896)3.53264187
8Oligodactyly (HP:0012165)3.23141590
9Anophthalmia (HP:0000528)3.08949271
10Facial hemangioma (HP:0000329)3.04760205
11Pseudobulbar signs (HP:0002200)2.99014735
12Ependymoma (HP:0002888)2.85438479
13Renal duplication (HP:0000075)2.84819263
14Bilateral microphthalmos (HP:0007633)2.78930401
15Abnormality of the diencephalon (HP:0010662)2.75446402
16Esophageal atresia (HP:0002032)2.74448866
17Abnormality of cochlea (HP:0000375)2.71902328
18Nephronophthisis (HP:0000090)2.67943547
19Ectopic kidney (HP:0000086)2.67379237
20Colon cancer (HP:0003003)2.64632907
21Oligodactyly (hands) (HP:0001180)2.64438010
22Hypoplastic pelvis (HP:0008839)2.62197394
23Mesangial abnormality (HP:0001966)2.60676599
24Coronal craniosynostosis (HP:0004440)2.59588106
25Aplasia/Hypoplasia of the sternum (HP:0006714)2.59285734
26High anterior hairline (HP:0009890)2.57397561
27Astrocytoma (HP:0009592)2.56761636
28Abnormality of the astrocytes (HP:0100707)2.56761636
29Morphological abnormality of the inner ear (HP:0011390)2.55096954
30Missing ribs (HP:0000921)2.54834292
31Broad thumb (HP:0011304)2.50263739
32Degeneration of anterior horn cells (HP:0002398)2.48816837
33Abnormality of the anterior horn cell (HP:0006802)2.48816837
34Sclerocornea (HP:0000647)2.45755200
35Vitreoretinal degeneration (HP:0000655)2.41734489
36Increased nuchal translucency (HP:0010880)2.40913002
37* Optic nerve hypoplasia (HP:0000609)2.39641940
38Pancreatic fibrosis (HP:0100732)2.39577337
39Large earlobe (HP:0009748)2.38635640
40Hemivertebrae (HP:0002937)2.38249529
41Molar tooth sign on MRI (HP:0002419)2.37417701
42Abnormality of midbrain morphology (HP:0002418)2.37417701
43True hermaphroditism (HP:0010459)2.34147777
44Selective tooth agenesis (HP:0001592)2.32150645
45Medial flaring of the eyebrow (HP:0010747)2.32122949
46Abnormality of the metopic suture (HP:0005556)2.30075859
47Renal dysplasia (HP:0000110)2.28409002
48Shallow orbits (HP:0000586)2.28031482
49Synostosis of carpal bones (HP:0005048)2.26180849
50Supernumerary ribs (HP:0005815)2.24060059
51Preaxial foot polydactyly (HP:0001841)2.23823022
52Partial duplication of the phalanx of hand (HP:0009999)2.22292059
53* Absent septum pellucidum (HP:0001331)2.22282268
54Hyperacusis (HP:0010780)2.21913384
55Supernumerary spleens (HP:0009799)2.20480033
56Fibular hypoplasia (HP:0003038)2.20125655
57Gait imbalance (HP:0002141)2.19721266
58Trigonocephaly (HP:0000243)2.19402569
59Abnormality of cells of the erythroid lineage (HP:0012130)2.16251124
60* Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16080888
61Glioma (HP:0009733)2.14150382
62Supernumerary bones of the axial skeleton (HP:0009144)2.13253993
63Congenital primary aphakia (HP:0007707)2.12017261
64Sex reversal (HP:0012245)2.11245339
65Abnormal sex determination (HP:0012244)2.11245339
66Duplication of thumb phalanx (HP:0009942)2.10093480
67Patellar aplasia (HP:0006443)2.09569601
68Triphalangeal thumb (HP:0001199)2.08568790
69Atresia of the external auditory canal (HP:0000413)2.07098818
70Medulloblastoma (HP:0002885)2.07019150
71Broad phalanges of the hand (HP:0009768)2.06760654
72Preauricular skin tag (HP:0000384)2.06398892
73Broad toe (HP:0001837)2.05581633
74Anencephaly (HP:0002323)2.05478644
75Skin tags (HP:0010609)2.04858155
76Abnormality of the renal medulla (HP:0100957)2.04855923
77Ankyloglossia (HP:0010296)2.04364472
78Overriding aorta (HP:0002623)2.03513205
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02038532
80Hip dysplasia (HP:0001385)2.00978257
81Broad foot (HP:0001769)2.00196395
82* Maternal diabetes (HP:0009800)2.00091228
83Pancreatic cysts (HP:0001737)1.99293928
84Vaginal atresia (HP:0000148)1.99142717
85Spinal muscular atrophy (HP:0007269)1.99131158
86Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98819408
87Cortical dysplasia (HP:0002539)1.98754166
88Postaxial hand polydactyly (HP:0001162)1.98487760
89Nephrogenic diabetes insipidus (HP:0009806)1.97975805
90Abnormality of the antihelix (HP:0009738)1.96173279
91Aplasia/Hypoplasia of the patella (HP:0006498)1.95797156
92Patellar dislocation (HP:0002999)1.94300875
93Genital tract atresia (HP:0001827)1.94005423
94Elfin facies (HP:0004428)1.93963905
95Chromsome breakage (HP:0040012)1.93574848
96Megalencephaly (HP:0001355)1.93410266
97Postaxial foot polydactyly (HP:0001830)1.93222541
98Down-sloping shoulders (HP:0200021)1.93034289
99Neoplasm of striated muscle (HP:0009728)1.92873522
100Abnormal lung lobation (HP:0002101)1.91992085
101Optic nerve coloboma (HP:0000588)1.91423642
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.90346534
103Spastic diplegia (HP:0001264)1.89406917
104Abnormality of chromosome segregation (HP:0002916)1.89341621
105Hyperglycinemia (HP:0002154)1.88878808
106Broad finger (HP:0001500)1.88500447
107Preaxial hand polydactyly (HP:0001177)1.88164388
108Stenosis of the external auditory canal (HP:0000402)1.87695019
109* Abnormality of the septum pellucidum (HP:0007375)1.86255219
110Meckel diverticulum (HP:0002245)1.86030930
111Poor coordination (HP:0002370)1.85423479
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85298406
113Hypoplasia of the ulna (HP:0003022)1.84692552
114Broad hallux (HP:0010055)1.84464043
115Adrenal hypoplasia (HP:0000835)1.84368020
116Carpal synostosis (HP:0009702)1.83724308
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.83530116
118Absent forearm bone (HP:0003953)1.82633323
119Aplasia involving forearm bones (HP:0009822)1.82633323
120Broad distal phalanx of finger (HP:0009836)1.82236636
121Spina bifida occulta (HP:0003298)1.82165138
122Skull defect (HP:0001362)1.81981490
123Gastrointestinal atresia (HP:0002589)1.81909523
12411 pairs of ribs (HP:0000878)1.81892509
125Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80965893
126Abnormality of DNA repair (HP:0003254)1.80851949
127Vertebral fusion (HP:0002948)1.80014185
128Abnormality of the aortic arch (HP:0012303)1.79582362
129Abnormality of the ileum (HP:0001549)1.79017682
130Hepatoblastoma (HP:0002884)1.78701700
131Truncus arteriosus (HP:0001660)1.78683294
132Holoprosencephaly (HP:0001360)1.76515688
133Macrocytic anemia (HP:0001972)1.76385352
134Proximal placement of thumb (HP:0009623)1.76081109
135Abnormality of the middle phalanges of the toes (HP:0010183)1.75701992
136Carpal bone hypoplasia (HP:0001498)1.75465373
137Heterotopia (HP:0002282)1.74831469
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.73929139
139Absent radius (HP:0003974)1.73801703
140Renovascular hypertension (HP:0100817)1.73709661
141Hypospadias (HP:0000047)1.73568861
142Pointed chin (HP:0000307)1.73195213
143Cutaneous finger syndactyly (HP:0010554)1.73142782
144Abnormality of the proximal phalanges of the hand (HP:0009834)1.73125872
145Specific learning disability (HP:0001328)1.73054411
146Depressed nasal ridge (HP:0000457)1.72665986
147Partial duplication of thumb phalanx (HP:0009944)1.72292690
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.72221086
149Intestinal atresia (HP:0011100)1.72144142
150Gastrointestinal carcinoma (HP:0002672)1.71376823
151Malignant gastrointestinal tract tumors (HP:0006749)1.71376823
152* Septo-optic dysplasia (HP:0100842)1.71244532
153Shawl scrotum (HP:0000049)1.70819256
154Neoplasm of the oral cavity (HP:0100649)1.70751459
155Broad phalanx (HP:0006009)1.70397960
156Short phalanx of the thumb (HP:0009660)1.69740977
157Abdominal situs inversus (HP:0003363)1.69203657
158Abnormality of abdominal situs (HP:0011620)1.69203657
159Arnold-Chiari malformation (HP:0002308)1.67771498
160Short 5th finger (HP:0009237)1.67599359
161Rectal fistula (HP:0100590)1.66665552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.54566508
2CDK123.48087741
3CDC73.44882775
4CDK193.41008544
5KSR13.39924146
6MAP3K103.34649764
7ICK2.87818725
8TYRO32.61500628
9EPHA42.59612706
10BUB12.41844166
11BCKDK2.32000420
12MKNK12.27109002
13FGFR22.16458791
14TLK11.97253416
15NTRK11.95704004
16STK161.85449464
17WEE11.85421260
18MKNK21.84275580
19WNK31.83893826
20NTRK21.82428269
21PLK41.79973065
22TNIK1.79432392
23BRD41.73124024
24MAP3K41.69612806
25ERBB21.63607753
26MAP2K71.62549902
27CDK71.61799047
28CASK1.54936504
29SIK31.49189035
30TTK1.47634484
31WNK41.46528710
32NEK21.45472658
33EEF2K1.44982168
34PAK41.39589753
35UHMK11.36432830
36BCR1.35970375
37SRPK11.32138253
38PLK21.31748425
39VRK21.30132659
40NEK11.25888868
41MTOR1.24735643
42PLK11.23982908
43MAPK151.23950356
44PASK1.21869515
45NUAK11.19397904
46PDGFRA1.18988073
47LATS21.16289131
48SIK11.16155283
49DYRK31.16059003
50PRKD31.15730932
51TRIB31.14293907
52CHEK21.14198118
53TESK21.11116292
54ATR1.10236259
55CDK61.08632991
56MAP4K21.07008052
57VRK11.05220370
58CHEK11.01787286
59NTRK31.00511451
60BMX0.99588126
61BMPR1B0.94887132
62CDK40.94714959
63LMTK20.93546098
64PINK10.93051247
65ALK0.91454591
66STK390.89843930
67MARK10.89401271
68PRKCG0.89239187
69PIK3CA0.87682466
70DMPK0.87332698
71BRSK20.87047152
72PLK30.86329514
73RPS6KB20.85909226
74MAPK130.85004853
75CDK180.84199159
76EIF2AK30.83991398
77CDK20.83757228
78TAF10.83747174
79ZAK0.81028438
80TSSK60.80727323
81CSNK1G20.80060654
82AURKB0.79975860
83ILK0.78271250
84PHKG20.78152009
85PHKG10.78152009
86FGFR10.77677755
87LATS10.77448790
88LRRK20.76189382
89CDK11A0.76172320
90DYRK1B0.74003849
91CDK150.73590648
92STK110.73171475
93AKT20.72638167
94WNK10.70638799
95CDK10.69970053
96CDK140.68783338
97CAMK1D0.68416284
98PAK60.67421962
99MAP2K40.65756735
100PAK20.64219564
101GRK10.64172029
102AURKA0.63737425
103ATM0.62746640
104PTK60.60747959
105ERBB40.60407039
106CSNK1E0.59988877
107CAMK10.59343621
108CDK30.57550518
109IRAK20.57188354
110MAP3K90.55911945
111CAMK1G0.54274796
112RPS6KA60.54273549
113CSNK1G30.53883703
114MAP3K80.53731905
115DYRK20.53591218
116CHUK0.53532052
117SGK2230.52896748
118SGK4940.52896748
119TGFBR10.52102965
120CSNK1D0.50794833
121MATK0.50515572
122SCYL20.50380253
123RPS6KA10.50340748
124RPS6KL10.49081836
125RPS6KC10.49081836
126CSNK1A1L0.48928306
127DYRK1A0.45814105
128PNCK0.45496650
129BRSK10.45169481
130MINK10.44963398
131GRK60.44819811
132PRKDC0.43643547
133DDR20.42911968
134AKT10.42255885
135PKN10.42194447
136STK40.42019240
137PRKCZ0.41490050
138CDK50.41114124
139ROCK20.38387059
140PAK10.37714649
141GSK3B0.35844081
142PKN20.35611923
143CDK80.35142972
144CSNK1G10.35048814
145MAPK90.33802469
146ERBB30.33260446

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.75558691
2Basal cell carcinoma_Homo sapiens_hsa052173.73156208
3DNA replication_Homo sapiens_hsa030303.52146699
4mRNA surveillance pathway_Homo sapiens_hsa030152.78536249
5Hedgehog signaling pathway_Homo sapiens_hsa043402.78412038
6RNA transport_Homo sapiens_hsa030132.77199946
7Notch signaling pathway_Homo sapiens_hsa043302.73532149
8Mismatch repair_Homo sapiens_hsa034302.66165891
9Hippo signaling pathway_Homo sapiens_hsa043902.56602850
10Cell cycle_Homo sapiens_hsa041102.49186489
11Base excision repair_Homo sapiens_hsa034102.44314967
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39744626
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09391205
14Steroid biosynthesis_Homo sapiens_hsa001001.98971249
15Ribosome_Homo sapiens_hsa030101.88961675
16MicroRNAs in cancer_Homo sapiens_hsa052061.87854524
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85879740
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85211738
19One carbon pool by folate_Homo sapiens_hsa006701.81896161
20Wnt signaling pathway_Homo sapiens_hsa043101.76601850
21RNA polymerase_Homo sapiens_hsa030201.73880987
22Cardiac muscle contraction_Homo sapiens_hsa042601.69234675
23Homologous recombination_Homo sapiens_hsa034401.60641738
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60057536
25Bladder cancer_Homo sapiens_hsa052191.59620374
26Oxidative phosphorylation_Homo sapiens_hsa001901.56887011
27Axon guidance_Homo sapiens_hsa043601.51790878
28Nucleotide excision repair_Homo sapiens_hsa034201.49373407
29Parkinsons disease_Homo sapiens_hsa050121.47722719
30Oocyte meiosis_Homo sapiens_hsa041141.46859966
31Huntingtons disease_Homo sapiens_hsa050161.46163690
32Melanogenesis_Homo sapiens_hsa049161.43098505
33Nicotine addiction_Homo sapiens_hsa050331.41247957
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34879183
35Lysine degradation_Homo sapiens_hsa003101.32036795
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29904996
37Chronic myeloid leukemia_Homo sapiens_hsa052201.29190281
38Colorectal cancer_Homo sapiens_hsa052101.27279669
39Endometrial cancer_Homo sapiens_hsa052131.26664410
40Adherens junction_Homo sapiens_hsa045201.26382579
41Linoleic acid metabolism_Homo sapiens_hsa005911.26183377
42Thyroid cancer_Homo sapiens_hsa052161.25973200
43Dorso-ventral axis formation_Homo sapiens_hsa043201.25468237
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23203433
45TGF-beta signaling pathway_Homo sapiens_hsa043501.20786754
46RNA degradation_Homo sapiens_hsa030181.18221156
47mTOR signaling pathway_Homo sapiens_hsa041501.18211422
48Glioma_Homo sapiens_hsa052141.17874397
49p53 signaling pathway_Homo sapiens_hsa041151.13656109
50Pyrimidine metabolism_Homo sapiens_hsa002401.12681001
51Basal transcription factors_Homo sapiens_hsa030221.10030185
52Folate biosynthesis_Homo sapiens_hsa007901.09747717
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.09528677
54HTLV-I infection_Homo sapiens_hsa051661.08951091
55Non-small cell lung cancer_Homo sapiens_hsa052231.08215626
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07330744
57Fanconi anemia pathway_Homo sapiens_hsa034601.04952603
58Biosynthesis of amino acids_Homo sapiens_hsa012300.98291035
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97548830
60Caffeine metabolism_Homo sapiens_hsa002320.95696647
61Protein export_Homo sapiens_hsa030600.95619994
62Pathways in cancer_Homo sapiens_hsa052000.94052141
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93893116
64Propanoate metabolism_Homo sapiens_hsa006400.93384422
65Small cell lung cancer_Homo sapiens_hsa052220.92741319
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92513096
67Tight junction_Homo sapiens_hsa045300.90879737
68Proteoglycans in cancer_Homo sapiens_hsa052050.90271262
69Alzheimers disease_Homo sapiens_hsa050100.85867199
70Phototransduction_Homo sapiens_hsa047440.85826685
71Renal cell carcinoma_Homo sapiens_hsa052110.85705677
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83569789
73Melanoma_Homo sapiens_hsa052180.83220327
74ErbB signaling pathway_Homo sapiens_hsa040120.79807214
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79131793
76Prostate cancer_Homo sapiens_hsa052150.77694611
77Butanoate metabolism_Homo sapiens_hsa006500.76629532
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75773803
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.74859143
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73633577
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73204075
82Epstein-Barr virus infection_Homo sapiens_hsa051690.72477713
83Viral myocarditis_Homo sapiens_hsa054160.69622667
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67613092
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66257246
86Prion diseases_Homo sapiens_hsa050200.64765238
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64708855
88Fat digestion and absorption_Homo sapiens_hsa049750.63815215
89Gap junction_Homo sapiens_hsa045400.63696805
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62740830
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61911183
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61867352
93Estrogen signaling pathway_Homo sapiens_hsa049150.61790800
94Viral carcinogenesis_Homo sapiens_hsa052030.61407290
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56826445
96Arginine and proline metabolism_Homo sapiens_hsa003300.55728396
97Ether lipid metabolism_Homo sapiens_hsa005650.53957917
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53840448
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51521439
100Proteasome_Homo sapiens_hsa030500.49183244
101Cocaine addiction_Homo sapiens_hsa050300.48521522
102AMPK signaling pathway_Homo sapiens_hsa041520.48030097
103Pancreatic cancer_Homo sapiens_hsa052120.47753515
104Alcoholism_Homo sapiens_hsa050340.47405885
105Insulin signaling pathway_Homo sapiens_hsa049100.45732282
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45188014
107Metabolic pathways_Homo sapiens_hsa011000.45071371
108Pyruvate metabolism_Homo sapiens_hsa006200.44949778
109Glutamatergic synapse_Homo sapiens_hsa047240.44457412
110GABAergic synapse_Homo sapiens_hsa047270.42584402
111Sulfur relay system_Homo sapiens_hsa041220.42401758
112Selenocompound metabolism_Homo sapiens_hsa004500.42370363
113Focal adhesion_Homo sapiens_hsa045100.42362377
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41955969
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41923482
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41564801
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41195890
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41044612
119Vitamin B6 metabolism_Homo sapiens_hsa007500.40954073
120Rap1 signaling pathway_Homo sapiens_hsa040150.39633180
121Morphine addiction_Homo sapiens_hsa050320.39137569
122Carbon metabolism_Homo sapiens_hsa012000.38695669
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37800295
124beta-Alanine metabolism_Homo sapiens_hsa004100.36300170
125Retinol metabolism_Homo sapiens_hsa008300.35323644
126VEGF signaling pathway_Homo sapiens_hsa043700.34837045
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34023710
128Taste transduction_Homo sapiens_hsa047420.33091104
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32830462
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.32452558
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.30789833
132Dopaminergic synapse_Homo sapiens_hsa047280.30374034
133Fatty acid biosynthesis_Homo sapiens_hsa000610.29978198
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.29774925
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29639964
136Purine metabolism_Homo sapiens_hsa002300.29178144
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28852169
138Circadian entrainment_Homo sapiens_hsa047130.28665810
139Non-homologous end-joining_Homo sapiens_hsa034500.28558161
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28249745
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28017866
142Herpes simplex infection_Homo sapiens_hsa051680.27130933
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24759139
144Nitrogen metabolism_Homo sapiens_hsa009100.23487976
145Prolactin signaling pathway_Homo sapiens_hsa049170.22488785

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