SOX30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.91769930
2cell-cell recognition (GO:0009988)9.75588982
3epithelial cilium movement (GO:0003351)9.71250186
4spermatid development (GO:0007286)9.51368083
5motile cilium assembly (GO:0044458)9.43945595
6piRNA metabolic process (GO:0034587)9.38385749
7regulation of cilium movement (GO:0003352)9.03297413
8reproduction (GO:0000003)8.90263846
9male meiosis (GO:0007140)8.10370186
10cilium movement (GO:0003341)8.05369920
11synaptonemal complex organization (GO:0070193)7.94424260
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.64932749
13synaptonemal complex assembly (GO:0007130)7.63004799
14single fertilization (GO:0007338)7.29243373
15protein targeting to Golgi (GO:0000042)6.88877813
16sperm capacitation (GO:0048240)6.84838248
17centriole replication (GO:0007099)6.76726216
18negative regulation of inclusion body assembly (GO:0090084)6.69142700
19establishment of protein localization to Golgi (GO:0072600)6.56369660
20microtubule depolymerization (GO:0007019)6.44918121
21* spermatogenesis (GO:0007283)6.43939266
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.43591443
23* male gamete generation (GO:0048232)6.41714089
24fertilization (GO:0009566)6.34053438
25rRNA methylation (GO:0031167)6.08604101
26DNA methylation involved in gamete generation (GO:0043046)6.07642500
27male meiosis I (GO:0007141)5.92115469
28* gamete generation (GO:0007276)5.90661339
29response to pheromone (GO:0019236)5.85828262
30organic cation transport (GO:0015695)5.75998285
31germ cell development (GO:0007281)5.53446814
32regulation of inclusion body assembly (GO:0090083)5.51384861
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.39697282
34regulation of microtubule-based movement (GO:0060632)5.38306394
35chromosome organization involved in meiosis (GO:0070192)5.28266642
36ventricular system development (GO:0021591)5.27910492
37phosphatidylethanolamine biosynthetic process (GO:0006646)5.23065109
38calcium ion-dependent exocytosis (GO:0017156)5.14641738
39rRNA modification (GO:0000154)5.05664919
40meiotic nuclear division (GO:0007126)4.99943741
41protein localization to Golgi apparatus (GO:0034067)4.89689448
42phosphatidylethanolamine metabolic process (GO:0046337)4.81679126
43meiosis I (GO:0007127)4.77468330
44histone H3-K9 demethylation (GO:0033169)4.70991798
45cell recognition (GO:0008037)4.68281706
46left/right pattern formation (GO:0060972)4.66852530
47* multicellular organismal reproductive process (GO:0048609)4.66183991
48seminiferous tubule development (GO:0072520)4.63214618
49microtubule severing (GO:0051013)4.48825754
50chromosome condensation (GO:0030261)4.40400786
51DNA packaging (GO:0006323)4.30810499
52glycerol ether metabolic process (GO:0006662)4.17642759
53spermatid nucleus differentiation (GO:0007289)4.15569111
54regulation of female gonad development (GO:2000194)4.12842981
55regulation of histone H3-K9 methylation (GO:0051570)4.10377823
56meiotic cell cycle (GO:0051321)4.08817075
57positive regulation of Rab GTPase activity (GO:0032851)4.06762326
58regulation of Rab GTPase activity (GO:0032313)4.06762326
59regulation of acrosome reaction (GO:0060046)3.87927997
60chaperone-mediated protein complex assembly (GO:0051131)3.86837337
61genitalia morphogenesis (GO:0035112)3.85779908
62ether metabolic process (GO:0018904)3.84878052
63multicellular organismal development (GO:0007275)3.77130680
64negative regulation of histone methylation (GO:0031061)3.72903578
65single strand break repair (GO:0000012)3.67836138
66monoubiquitinated protein deubiquitination (GO:0035520)3.66968913
67protein localization to cilium (GO:0061512)3.64412727
68cellular ketone body metabolic process (GO:0046950)3.63756091
69chromatin silencing (GO:0006342)3.58539095
70gene silencing by RNA (GO:0031047)3.54775085
71microtubule nucleation (GO:0007020)3.51730981
72protein polyglutamylation (GO:0018095)3.50820395
73regulation of meiosis I (GO:0060631)3.45518949
74female gamete generation (GO:0007292)3.43691167
75histone exchange (GO:0043486)3.41412631
76negative regulation of organelle assembly (GO:1902116)3.38008147
77oocyte development (GO:0048599)3.35488726
78meiotic cell cycle process (GO:1903046)3.34355984
79regulation of spindle checkpoint (GO:0090231)3.33126207
80mitotic sister chromatid cohesion (GO:0007064)3.32998655
81microtubule polymerization or depolymerization (GO:0031109)3.31883728
82amino-acid betaine transport (GO:0015838)3.30202511
83carnitine transport (GO:0015879)3.30202511
84glomerular visceral epithelial cell development (GO:0072015)3.25293091
85cerebral cortex neuron differentiation (GO:0021895)3.23880184
86response to acidic pH (GO:0010447)3.21610248
87protein refolding (GO:0042026)3.21047244
88carnitine transmembrane transport (GO:1902603)3.19965758
89ketone body metabolic process (GO:1902224)3.17504130
90cellular response to pH (GO:0071467)3.16478648
91synapsis (GO:0007129)3.15867677
92nucleus organization (GO:0006997)3.12858100
93regulation of transcription involved in cell fate commitment (GO:0060850)3.10532738
94musculoskeletal movement (GO:0050881)3.09075389
95multicellular organismal movement (GO:0050879)3.09075389
96oogenesis (GO:0048477)3.07164500
97glomerular epithelial cell development (GO:0072310)3.05919457
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05654289
99nucleosome disassembly (GO:0006337)3.04625841
100protein-DNA complex disassembly (GO:0032986)3.04625841
101intraciliary transport (GO:0042073)3.02211139
102cilium organization (GO:0044782)2.98025347
103glycolytic process (GO:0006096)2.96070843
104microtubule-based movement (GO:0007018)2.95146802
105axoneme assembly (GO:0035082)2.94110483
106nuclear pore complex assembly (GO:0051292)2.92368172
107protein K11-linked deubiquitination (GO:0035871)2.89749192
108polyol catabolic process (GO:0046174)2.87662638
109regulation of centriole replication (GO:0046599)2.86414991
110RNA destabilization (GO:0050779)2.86116697
111cilium assembly (GO:0042384)2.85763652
112cilium morphogenesis (GO:0060271)2.81392138
113sexual reproduction (GO:0019953)2.81073247
114gene silencing (GO:0016458)2.80923937
115RNA localization (GO:0006403)2.79050247
116nucleoside diphosphate phosphorylation (GO:0006165)2.78357037
117negative regulation of skeletal muscle tissue development (GO:0048642)2.77428102
118cellular component assembly involved in morphogenesis (GO:0010927)2.74333033
119alditol metabolic process (GO:0019400)2.73154319
120lactate metabolic process (GO:0006089)2.67473168
121interferon-gamma secretion (GO:0072643)2.64783299
122centriole assembly (GO:0098534)2.60798098
123peptidyl-glutamic acid modification (GO:0018200)2.59030757
124sex differentiation (GO:0007548)2.57711887
125regulation of cilium assembly (GO:1902017)2.53389596
126fusion of sperm to egg plasma membrane (GO:0007342)13.2697231
127sperm motility (GO:0030317)13.2416055
128acrosome reaction (GO:0007340)11.5160432
129cilium or flagellum-dependent cell motility (GO:0001539)11.2349456
130sperm-egg recognition (GO:0035036)10.9110287
131multicellular organism reproduction (GO:0032504)10.6431830
132axonemal dynein complex assembly (GO:0070286)10.1931682
133cell wall macromolecule catabolic process (GO:0016998)10.1302175
134cell wall macromolecule metabolic process (GO:0044036)10.1302175
135acrosome assembly (GO:0001675)10.1246985
136plasma membrane fusion (GO:0045026)10.0766450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03231019
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.64079455
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.12326075
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94721017
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.89304170
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87953371
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.75928354
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73100383
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67834640
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53653377
11VDR_22108803_ChIP-Seq_LS180_Human2.52290672
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48492609
13FUS_26573619_Chip-Seq_HEK293_Human2.37432133
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30618263
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21901872
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.13178044
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.00707268
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0004323
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.96856509
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95839814
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94423343
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.91628570
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88688434
24RAC3_21632823_ChIP-Seq_H3396_Human1.87253937
25ERA_21632823_ChIP-Seq_H3396_Human1.83851779
26ER_23166858_ChIP-Seq_MCF-7_Human1.79589069
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71751614
28STAT1_17558387_ChIP-Seq_HELA_Human1.71640024
29ZNF274_21170338_ChIP-Seq_K562_Hela1.71133671
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69792692
31AR_25329375_ChIP-Seq_VCAP_Human1.62425457
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.62185553
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.62152969
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58689003
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57869369
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.57475866
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.57325575
38* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54863825
39DROSHA_22980978_ChIP-Seq_HELA_Human1.52372048
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49996193
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.48214022
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47448116
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44767032
44P300_19829295_ChIP-Seq_ESCs_Human1.42697819
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42284081
46SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41930718
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.40438468
48CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39866793
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39828310
50* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.39562441
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.39055322
52TAF2_19829295_ChIP-Seq_ESCs_Human1.38669080
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38260335
54CBP_20019798_ChIP-Seq_JUKART_Human1.38260335
55RUNX2_22187159_ChIP-Seq_PCA_Human1.37244688
56BCL6_27268052_Chip-Seq_Bcells_Human1.36879881
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.36431824
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36431737
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.36267689
60RBPJ_21746931_ChIP-Seq_IB4_Human1.35656249
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35654616
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34636639
63* OCT4_20526341_ChIP-Seq_ESCs_Human1.34356861
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.34147981
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34008489
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33794186
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33044821
68* KDM2B_26808549_Chip-Seq_REH_Human1.29563179
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.29135708
70BCOR_27268052_Chip-Seq_Bcells_Human1.28870054
71REST_21632747_ChIP-Seq_MESCs_Mouse1.26400410
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.25770285
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25702417
74P53_21459846_ChIP-Seq_SAOS-2_Human1.25667761
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.24774847
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24351825
77PHF8_20622854_ChIP-Seq_HELA_Human1.24265603
78SMAD4_21799915_ChIP-Seq_A2780_Human1.23673697
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23362820
80P68_20966046_ChIP-Seq_HELA_Human1.22636841
81SMC4_20622854_ChIP-Seq_HELA_Human1.22500371
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22497870
83STAT3_23295773_ChIP-Seq_U87_Human1.22415826
84CEBPB_22108803_ChIP-Seq_LS180_Human1.22405893
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.21232567
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19457399
87GF1_26923725_Chip-Seq_HPCs_Mouse1.19154780
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18972854
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18971402
90CTCF_27219007_Chip-Seq_Bcells_Human1.18821721
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18292235
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18290024
93TP63_22573176_ChIP-Seq_HFKS_Human1.17994445
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17851809
95TP53_18474530_ChIP-ChIP_U2OS_Human1.17835005
96* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17530306
97P300_27268052_Chip-Seq_Bcells_Human1.17426266
98FOXH1_21741376_ChIP-Seq_EPCs_Human1.17226033
99PHF8_20622853_ChIP-Seq_HELA_Human1.16410476
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.16178111
101SOX2_19829295_ChIP-Seq_ESCs_Human1.15282935
102NANOG_19829295_ChIP-Seq_ESCs_Human1.15282935
103E2F1_20622854_ChIP-Seq_HELA_Human1.14978959
104* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14681896
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.13097718
106SMRT_27268052_Chip-Seq_Bcells_Human1.12826505
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12685391
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12308813
109KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12082169
110TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11961879
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.11927991
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11825481
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11814107
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11725851
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09963560
116CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09624434
117KLF4_19829295_ChIP-Seq_ESCs_Human1.08516719
118HOXB7_26014856_ChIP-Seq_BT474_Human1.08139662
119E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07108008
120PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06809933
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05621162
122RNF2_27304074_Chip-Seq_NSC_Mouse1.05495574
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05267144
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04939549
125TAF15_26573619_Chip-Seq_HEK293_Human1.04652650
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04315739
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04099559
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.03875902
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02174523
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01609496
131MYC_27129775_Chip-Seq_CORNEA_Mouse1.01355379
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00794241
133NFYB_21822215_ChIP-Seq_K562_Human1.00705783
134EZH2_27294783_Chip-Seq_NPCs_Mouse1.00085776
135* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99659624
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.99194585
137ERG_20517297_ChIP-Seq_VCAP_Human0.98902720
138* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98768024
139* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98768024
140ETV1_20927104_ChIP-Seq_GIST48_Human0.97666728
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97663785
142* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97418388
143SOX11_22085726_ChIP-Seq_ESNs_Mouse0.96396237
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.95919344
145* SPI1_26923725_Chip-Seq_HPCs_Mouse0.95890020
146TBL1_22424771_ChIP-Seq_293T_Human0.95746950
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95610631
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94433622
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93527521
150P53_22387025_ChIP-Seq_ESCs_Mouse0.92888428
151NANOG_20526341_ChIP-Seq_ESCs_Human0.92235489
152SOX2_21211035_ChIP-Seq_LN229_Human0.91748528
153CTCF_20526341_ChIP-Seq_ESCs_Human0.91423030
154STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90972785
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.90894488
156* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90493938
157MYC_19829295_ChIP-Seq_ESCs_Human0.88994773
158KLF4_18555785_Chip-Seq_ESCs_Mouse0.88721041
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87841373
160ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87279666
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86831162
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86754510
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.86707113
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86644994
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86544686
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86475730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.98396035
2MP0001929_abnormal_gametogenesis5.47676292
3MP0008877_abnormal_DNA_methylation5.22127459
4MP0003718_maternal_effect4.82160206
5MP0002210_abnormal_sex_determination3.70105400
6MP0002161_abnormal_fertility/fecundity3.29191508
7MP0001145_abnormal_male_reproductive3.10627403
8MP0002653_abnormal_ependyma_morphology2.91634997
9MP0005670_abnormal_white_adipose2.88175253
10MP0000653_abnormal_sex_gland2.71771042
11MP0001348_abnormal_lacrimal_gland2.59200645
12MP0000678_abnormal_parathyroid_gland2.41294635
13MP0005395_other_phenotype2.00673048
14MP0005410_abnormal_fertilization15.3712466
15MP0005623_abnormal_meninges_morphology1.96501534
16MP0002160_abnormal_reproductive_system1.74441937
17MP0008789_abnormal_olfactory_epithelium1.74098577
18MP0006292_abnormal_olfactory_placode1.66445772
19MP0008995_early_reproductive_senescence1.62935161
20MP0003646_muscle_fatigue1.61358522
21MP0002138_abnormal_hepatobiliary_system1.58780940
22MP0002132_abnormal_respiratory_system1.51339758
23MP0005499_abnormal_olfactory_system1.51169305
24MP0005394_taste/olfaction_phenotype1.51169305
25MP0002282_abnormal_trachea_morphology1.35393163
26MP0001486_abnormal_startle_reflex1.31682081
27MP0008058_abnormal_DNA_repair1.31667449
28MP0005379_endocrine/exocrine_gland_phen1.29588907
29MP0004233_abnormal_muscle_weight1.27231649
30MP0001485_abnormal_pinna_reflex1.26979334
31MP0005310_abnormal_salivary_gland1.22796172
32MP0002249_abnormal_larynx_morphology1.20280756
33MP0005451_abnormal_body_composition1.16341209
34MP0002102_abnormal_ear_morphology1.08936250
35MP0003693_abnormal_embryo_hatching1.07491390
36MP0003878_abnormal_ear_physiology1.05944957
37MP0005377_hearing/vestibular/ear_phenot1.05944957
38MP0001765_abnormal_ion_homeostasis0.99900901
39MP0010094_abnormal_chromosome_stability0.97874872
40MP0002127_abnormal_cardiovascular_syste0.97685506
41MP0003115_abnormal_respiratory_system0.96212371
42MP0005647_abnormal_sex_gland0.93438991
43MP0002735_abnormal_chemical_nociception0.91369531
44MP0001984_abnormal_olfaction0.88334343
45MP0003111_abnormal_nucleus_morphology0.84870901
46MP0000026_abnormal_inner_ear0.84774217
47MP0005389_reproductive_system_phenotype0.82509753
48MP0008004_abnormal_stomach_pH0.82070029
49MP0004742_abnormal_vestibular_system0.78968084
50MP0009046_muscle_twitch0.76902399
51MP0003786_premature_aging0.75582289
52MP0005360_urolithiasis0.73418320
53MP0005666_abnormal_adipose_tissue0.72176493
54MP0000566_synostosis0.68382443
55MP0001666_abnormal_nutrient_absorption0.66666090
56MP0000049_abnormal_middle_ear0.66208393
57MP0009053_abnormal_anal_canal0.66041515
58MP0010368_abnormal_lymphatic_system0.65058063
59MP0002139_abnormal_hepatobiliary_system0.64824779
60MP0003119_abnormal_digestive_system0.64464936
61MP0005248_abnormal_Harderian_gland0.63647517
62MP0009278_abnormal_bone_marrow0.61636537
63MP0001293_anophthalmia0.61542567
64MP0004859_abnormal_synaptic_plasticity0.59955518
65MP0009697_abnormal_copulation0.59917393
66MP0003942_abnormal_urinary_system0.58817845
67MP0002234_abnormal_pharynx_morphology0.58735352
68MP0001968_abnormal_touch/_nociception0.57962940
69MP0003699_abnormal_female_reproductive0.56312020
70MP0000534_abnormal_ureter_morphology0.55817037
71MP0002067_abnormal_sensory_capabilities0.55804897
72MP0001727_abnormal_embryo_implantation0.55420933
73MP0005551_abnormal_eye_electrophysiolog0.54956728
74MP0005253_abnormal_eye_physiology0.54151877
75MP0000681_abnormal_thyroid_gland0.54050157
76MP0004085_abnormal_heartbeat0.53798234
77MP0003011_delayed_dark_adaptation0.53770338
78MP0004957_abnormal_blastocyst_morpholog0.51747411
79MP0008057_abnormal_DNA_replication0.51664627
80MP0003950_abnormal_plasma_membrane0.51505516
81MP0001324_abnormal_eye_pigmentation0.51363618
82MP0002272_abnormal_nervous_system0.50700119
83MP0000358_abnormal_cell_content/0.50132784
84MP0002928_abnormal_bile_duct0.48003426
85MP0002822_catalepsy0.47725597
86MP0001119_abnormal_female_reproductive0.47259316
87MP0004036_abnormal_muscle_relaxation0.45295674
88MP0005636_abnormal_mineral_homeostasis0.45052735
89MP0000955_abnormal_spinal_cord0.44987699
90MP0005391_vision/eye_phenotype0.44094989
91MP0001545_abnormal_hematopoietic_system0.43699215
92MP0005397_hematopoietic_system_phenotyp0.43699215
93MP0008007_abnormal_cellular_replicative0.42627812
94MP0003787_abnormal_imprinting0.42351879
95MP0000569_abnormal_digit_pigmentation0.41659102
96MP0001905_abnormal_dopamine_level0.41483924
97MP0009115_abnormal_fat_cell0.39905693
98MP0001879_abnormal_lymphatic_vessel0.39756626
99MP0002557_abnormal_social/conspecific_i0.39737967
100MP0002269_muscular_atrophy0.39510032
101MP0001501_abnormal_sleep_pattern0.39307604
102MP0001730_embryonic_growth_arrest0.38992529
103MP0003879_abnormal_hair_cell0.38519383
104MP0000470_abnormal_stomach_morphology0.36059057
105MP0003861_abnormal_nervous_system0.35928425
106MP0001986_abnormal_taste_sensitivity0.35686479
107MP0001919_abnormal_reproductive_system0.35631782
108MP0001764_abnormal_homeostasis0.35503479
109MP0010307_abnormal_tumor_latency0.35474546
110MP0006276_abnormal_autonomic_nervous0.35165111
111MP0002572_abnormal_emotion/affect_behav0.34777328
112MP0005367_renal/urinary_system_phenotyp0.34530570
113MP0000516_abnormal_urinary_system0.34530570
114MP0005423_abnormal_somatic_nervous0.31580340
115MP0001661_extended_life_span0.31345685
116MP0003077_abnormal_cell_cycle0.30535622
117MP0002971_abnormal_brown_adipose0.30510513
118MP0000751_myopathy0.29594744
119MP0006072_abnormal_retinal_apoptosis0.27884663
120MP0005380_embryogenesis_phenotype0.27811766
121MP0001672_abnormal_embryogenesis/_devel0.27811766
122MP0005375_adipose_tissue_phenotype0.27747684
123MP0002084_abnormal_developmental_patter0.27499518
124MP0003137_abnormal_impulse_conducting0.26654700
125MP0002092_abnormal_eye_morphology0.26533346
126MP0005535_abnormal_body_temperature0.26425326
127MP0004808_abnormal_hematopoietic_stem0.26134933
128MP0009672_abnormal_birth_weight0.25550521
129MP0008961_abnormal_basal_metabolism0.25492243
130MP0000313_abnormal_cell_death0.24608352
131MP0003329_amyloid_beta_deposits0.24533020
132MP0003936_abnormal_reproductive_system0.24218662
133MP0002152_abnormal_brain_morphology0.23980252
134MP0003948_abnormal_gas_homeostasis0.22129237
135MP0004197_abnormal_fetal_growth/weight/0.19519229
136MP0002169_no_abnormal_phenotype0.19481409
137MP0002873_normal_phenotype0.19167888
138MP0005195_abnormal_posterior_eye0.19007333
139MP0003984_embryonic_growth_retardation0.18458552
140MP0001697_abnormal_embryo_size0.18208914
141MP0002085_abnormal_embryonic_tissue0.18116454
142MP0002295_abnormal_pulmonary_circulatio0.17630179
143MP0001963_abnormal_hearing_physiology0.17263441
144MP0002229_neurodegeneration0.16976029
145MP0004811_abnormal_neuron_physiology0.16864037
146MP0002088_abnormal_embryonic_growth/wei0.16700311
147MP0003045_fibrosis0.16672387
148MP0009703_decreased_birth_body0.16236259
149MP0004133_heterotaxia0.15788542
150MP0002697_abnormal_eye_size0.15453751
151MP0003959_abnormal_lean_body0.14746688
152MP0002796_impaired_skin_barrier0.14457894

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.98303846
2Abnormal respiratory motile cilium morphology (HP:0005938)8.98303846
3Abnormal respiratory motile cilium physiology (HP:0012261)8.86143381
4Rhinitis (HP:0012384)7.33849209
5Abnormal ciliary motility (HP:0012262)6.98215356
6Infertility (HP:0000789)6.76719588
7Chronic bronchitis (HP:0004469)6.73323618
8Severe visual impairment (HP:0001141)6.62568835
9Nasal polyposis (HP:0100582)6.13607688
10Chronic hepatic failure (HP:0100626)5.06578037
11Abnormality of the nasal mucosa (HP:0000433)5.01116551
12Male infertility (HP:0003251)4.85657152
13Resting tremor (HP:0002322)4.57349898
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47111840
15Bronchitis (HP:0012387)4.46820297
16Bronchiectasis (HP:0002110)4.44439469
17Nephronophthisis (HP:0000090)4.44295369
18Cone-rod dystrophy (HP:0000548)4.34169588
19Bony spicule pigmentary retinopathy (HP:0007737)4.17072631
20Abnormal spermatogenesis (HP:0008669)4.11849513
21Hyperkalemia (HP:0002153)3.99322820
22Abnormality of macular pigmentation (HP:0008002)3.85536105
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.65411765
24Osteomalacia (HP:0002749)3.48110397
25Abnormality of the renal medulla (HP:0100957)3.36267020
26Recurrent otitis media (HP:0000403)3.27662475
27Recurrent sinusitis (HP:0011108)3.23595369
28Impulsivity (HP:0100710)3.18494283
29Progressive sensorineural hearing impairment (HP:0000408)3.16009737
30Menstrual irregularities (HP:0000858)3.06302854
31Postural instability (HP:0002172)3.05137847
32Gonadotropin excess (HP:0000837)3.03588535
33Hypoalphalipoproteinemia (HP:0003233)3.01892852
34Tubulointerstitial nephritis (HP:0001970)3.01044464
35Hypoplasia of the thymus (HP:0000778)2.96057303
36Recurrent bronchitis (HP:0002837)2.95818083
37Hypophosphatemic rickets (HP:0004912)2.90073499
38Azoospermia (HP:0000027)2.88259025
39Abnormal rod and cone electroretinograms (HP:0008323)2.84720395
40Anterior segment dysgenesis (HP:0007700)2.66227743
41Potter facies (HP:0002009)2.65113065
42Facial shape deformation (HP:0011334)2.65113065
43Generalized aminoaciduria (HP:0002909)2.62340408
44Tubular atrophy (HP:0000092)2.61965530
45Abnormality of midbrain morphology (HP:0002418)2.56552888
46Molar tooth sign on MRI (HP:0002419)2.56552888
47Enlarged epiphyses (HP:0010580)2.55088181
48Abnormality of dental color (HP:0011073)2.54984192
49Insulin-resistant diabetes mellitus (HP:0000831)2.52901724
50Progressive cerebellar ataxia (HP:0002073)2.51053088
51Renovascular hypertension (HP:0100817)2.49329292
52Portal hypertension (HP:0001409)2.48500319
53Subcapsular cataract (HP:0000523)2.42954877
54Tubulointerstitial abnormality (HP:0001969)2.42485100
55Abnormality of abdominal situs (HP:0011620)2.36327431
56Abdominal situs inversus (HP:0003363)2.36327431
57Amelogenesis imperfecta (HP:0000705)2.34433141
58Horizontal nystagmus (HP:0000666)2.32016950
59Hypergonadotropic hypogonadism (HP:0000815)2.31546107
60Oligodactyly (hands) (HP:0001180)2.31037036
61Abnormality of the hepatic vasculature (HP:0006707)2.27749135
62Cholecystitis (HP:0001082)2.26907141
63Abnormal gallbladder physiology (HP:0012438)2.26907141
64Optic nerve hypoplasia (HP:0000609)2.24417512
65Abnormality of the lower motor neuron (HP:0002366)2.23694718
66Medial flaring of the eyebrow (HP:0010747)2.21900125
67Hypoplastic ischia (HP:0003175)2.20626664
68Progressive hearing impairment (HP:0001730)2.16576179
69Myokymia (HP:0002411)2.15335696
70Abnormality of potassium homeostasis (HP:0011042)2.10039843
71Hyperuricemia (HP:0002149)2.09328507
72Increased purine levels (HP:0004368)2.09328507
73Abnormality of the costochondral junction (HP:0000919)2.05440383
74Sensory axonal neuropathy (HP:0003390)2.03593554
75Congenital sensorineural hearing impairment (HP:0008527)2.03482199
76Intellectual disability, moderate (HP:0002342)2.02148682
77Spastic tetraparesis (HP:0001285)2.01503719
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.1297494
79Absent/shortened dynein arms (HP:0200106)13.1297494
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7259084
81Dyschromatopsia (HP:0007641)1.98822263
82Stage 5 chronic kidney disease (HP:0003774)1.97445706
83Heterotopia (HP:0002282)1.94143045
84Duodenal stenosis (HP:0100867)1.94138613
85Small intestinal stenosis (HP:0012848)1.94138613
86Postaxial foot polydactyly (HP:0001830)1.93997298
87Volvulus (HP:0002580)1.92884068
88Abnormality of the ischium (HP:0003174)1.92492723
89Photophobia (HP:0000613)1.88925098
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88491513
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83938340
92Tubulointerstitial fibrosis (HP:0005576)1.83686934
93Choroideremia (HP:0001139)1.81219067
94Fibular hypoplasia (HP:0003038)1.80704096
95Short ribs (HP:0000773)1.79940656
96Abnormal biliary tract physiology (HP:0012439)1.78935468
97Bile duct proliferation (HP:0001408)1.78935468
98Amyotrophic lateral sclerosis (HP:0007354)1.77873839
99Hyponatremia (HP:0002902)1.76953616
100Abnormality of the aortic arch (HP:0012303)1.75229273
101Facial hemangioma (HP:0000329)1.75021439
102Congenital hepatic fibrosis (HP:0002612)1.74966883
103Abnormal drinking behavior (HP:0030082)1.74348026
104Polydipsia (HP:0001959)1.74348026
105Abnormality of the renal cortex (HP:0011035)1.73514939
106Bell-shaped thorax (HP:0001591)1.73435629
107Scotoma (HP:0000575)1.72721114
108Decreased central vision (HP:0007663)1.72034485
109Focal segmental glomerulosclerosis (HP:0000097)1.71065109
110Renal Fanconi syndrome (HP:0001994)1.69788086
111Lip pit (HP:0100267)1.69632268
112Polyuria (HP:0000103)1.69536194
113Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67649424
114Sandal gap (HP:0001852)1.67351863
115Facial cleft (HP:0002006)1.62861872
116Abnormality of dentin (HP:0010299)1.62402170
117Oculomotor apraxia (HP:0000657)1.61654033
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.61581438
119Hypoplasia of the fovea (HP:0007750)1.61581438
120Absent frontal sinuses (HP:0002688)1.59818642
121Renal dysplasia (HP:0000110)1.59408350
122Deformed sella turcica (HP:0002681)1.55069324
123Abnormality of the dental root (HP:0006486)1.53979504
124Taurodontia (HP:0000679)1.53979504
125Abnormality of permanent molar morphology (HP:0011071)1.53979504
126J-shaped sella turcica (HP:0002680)1.52354332
127Abnormality of renal excretion (HP:0011036)1.51486216
128Postaxial hand polydactyly (HP:0001162)1.46498797
129Microglossia (HP:0000171)1.45667680
130Absent epiphyses (HP:0010577)1.45572511
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45572511
132Supernumerary spleens (HP:0009799)1.45318978
133Abnormality of molar morphology (HP:0011070)1.44060315
134Abnormality of molar (HP:0011077)1.44060315
135Bundle branch block (HP:0011710)1.43219332
136Hemorrhage of the eye (HP:0011885)1.42795613
137Impaired proprioception (HP:0010831)1.38427243
138Abnormality of the dental pulp (HP:0006479)1.38325903
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.37750584
140Short thorax (HP:0010306)1.36910114
141Broad distal phalanx of finger (HP:0009836)1.36517920
142Aplasia/Hypoplasia of the lens (HP:0008063)1.35974505
143Hemiparesis (HP:0001269)1.34718008
144Asymmetric septal hypertrophy (HP:0001670)1.33049543
145Truncal obesity (HP:0001956)1.32666431
146Cystic liver disease (HP:0006706)1.31940721
147Median cleft lip (HP:0000161)1.29043767
148Abnormal urine output (HP:0012590)1.28689428
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27790726
150Ectopic kidney (HP:0000086)1.26667462
151Hyporeflexia of lower limbs (HP:0002600)1.25788805
152Attenuation of retinal blood vessels (HP:0007843)1.22870208
153Decreased motor nerve conduction velocity (HP:0003431)1.19156581
154Abnormality of the sella turcica (HP:0002679)1.18885223
155Nephropathy (HP:0000112)1.18777861
156Double outlet right ventricle (HP:0001719)1.18655080
157Congenital malformation of the right heart (HP:0011723)1.18655080
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.17725679
159Short femoral neck (HP:0100864)1.17423337
160Gait imbalance (HP:0002141)1.15152038
161Congenital primary aphakia (HP:0007707)1.15097630
162Pancreatic fibrosis (HP:0100732)1.14174496
163Chronic sinusitis (HP:0011109)1.13803933
164Neurofibrillary tangles (HP:0002185)1.13679430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.85275637
2PDK47.85275637
3TESK16.07485927
4PRKD35.86553315
5PDK25.01255309
6ICK4.60190355
7BRD43.95949579
8INSRR3.60474032
9PLK23.20335596
10DDR22.62318192
11MAP3K92.54280253
12PTK2B2.37585528
13PNCK2.37273122
14MAP4K22.23408851
15WNK42.13310522
16ARAF1.99941584
17STK391.94307731
18PIK3CG1.79781723
19NEK21.77198832
20STK381.73932855
21MAP3K131.66413567
22MST1R1.54706463
23DYRK1B1.50376152
24CDK71.37943477
25MET1.36252516
26KSR21.30544992
27CDK191.08188768
28MAPK151.03859933
29WNK11.01647431
30CAMK1G0.95282401
31PDK10.93263308
32TYRO30.91660222
33TTK0.88568782
34DYRK30.88052211
35STK30.86160120
36CDC70.75453101
37ACVR1B0.74210513
38CAMK1D0.73419977
39CCNB10.72136310
40PASK0.71781054
41TIE10.69513614
42CDK90.69509827
43ZAK0.69292714
44STK38L0.68766329
45LATS20.66112920
46AKT30.66066020
47CHEK20.63636596
48OXSR10.62979989
49CDK120.61879458
50TAOK30.61296847
51CAMK10.59383782
52MOS0.59163526
53CHEK10.57597817
54PINK10.56258416
55MAP3K80.55134406
56PRKG20.54342227
57EEF2K0.53493548
58IRAK10.52851397
59PLK40.50013754
60MAP2K60.49558042
61TESK20.48707488
62PDPK10.46077587
63BRSK10.45556483
64ATM0.43305385
65ATR0.42988933
66PAK20.42053080
67MAP3K10.41628711
68PAK10.41420770
69VRK10.40866327
70MTOR0.40568043
71LMTK20.35082280
72WEE10.34444304
73PRKAA20.33205433
74MAP2K20.32004972
75RIPK40.31451195
76BMPR1B0.31009722
77PRKAA10.30550104
78NTRK20.29412396
79TLK10.29386727
80TNIK0.28853892
81IRAK20.28764676
82PLK10.28702112
83ROCK10.28106855
84SIK20.27626256
85CSF1R0.26816586
86SGK10.26501992
87MAP3K100.26326629
88MAP3K20.25204342
89NTRK30.24965628
90PRKCG0.23739005
91RPS6KA20.22055747
92PAK40.22023627
93MARK20.21828569
94NEK60.21175548
95RAF10.20684406
96MAPK140.18918025
97MAPK100.18102763
98CAMK40.17595743
99MUSK0.17396339
100RPS6KB10.17033837
101LATS10.16739147
102SGK2230.15777243
103SGK4940.15777243
104TRIM280.15152815
105CDK40.14871206
106PAK60.14631178
107CAMKK10.14396012
108GRK10.13045693
109CSNK1D0.12550494
110PRKCZ0.11387373
111GSK3B0.11018620
112MAP3K40.10796390
113CDK20.10553569
114PRKCI0.09890530
115CDK10.09490641
116STK110.09122356
117MAP2K70.07033257
118CDK30.05903580
119CDK150.05506521
120RPS6KA10.04848496
121MARK10.04748233
122MARK30.04397832
123MAPKAPK50.04210008
124CDK60.04027474
125PRKCB0.03758851
126PRKDC0.03754895
127CSNK2A10.03507832
128EGFR0.03434090
129MAPK80.03227274
130WNK30.03124811
131CDK180.03015388
132CAMK2A0.02968044
133BRSK20.02748205
134CLK10.02493956
135BRAF0.02054315
136CDK11A0.01813490
137CSNK2A20.01806568
138PKN10.01165902
139CDC42BPA0.00992309
140PDGFRB0.00710997
141PRKACB0.00567498
142PRKCQ0.00286128
143TAOK1-0.0135432
144PRKACG-0.0124692
145PRKG1-0.0123815
146RPS6KA3-0.0105830
147MAPK1-0.0087435
148PIM1-0.0041500
149AURKA-0.0014846

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.93395954
2Fatty acid biosynthesis_Homo sapiens_hsa000614.30023949
3Olfactory transduction_Homo sapiens_hsa047404.27654484
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.21276720
5Pyruvate metabolism_Homo sapiens_hsa006203.39176061
6Vitamin B6 metabolism_Homo sapiens_hsa007503.17517134
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.13514292
8Linoleic acid metabolism_Homo sapiens_hsa005913.05303223
9Basal transcription factors_Homo sapiens_hsa030222.66554127
10Glucagon signaling pathway_Homo sapiens_hsa049222.63346576
11Propanoate metabolism_Homo sapiens_hsa006402.59872295
12Dorso-ventral axis formation_Homo sapiens_hsa043202.55860447
13Fanconi anemia pathway_Homo sapiens_hsa034602.35499776
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34345513
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19406103
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17514572
17Selenocompound metabolism_Homo sapiens_hsa004502.13973245
18Glycerolipid metabolism_Homo sapiens_hsa005612.00556650
19Butanoate metabolism_Homo sapiens_hsa006501.95730608
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92169574
21Oocyte meiosis_Homo sapiens_hsa041141.90941653
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71196526
23PPAR signaling pathway_Homo sapiens_hsa033201.70121918
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.67900451
25mRNA surveillance pathway_Homo sapiens_hsa030151.63949493
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.61588644
27Caffeine metabolism_Homo sapiens_hsa002321.51097833
28Fructose and mannose metabolism_Homo sapiens_hsa000511.49151160
29Amphetamine addiction_Homo sapiens_hsa050311.46555980
30Ether lipid metabolism_Homo sapiens_hsa005651.45201408
31Pentose phosphate pathway_Homo sapiens_hsa000301.45196276
32Allograft rejection_Homo sapiens_hsa053301.41708394
33RNA transport_Homo sapiens_hsa030131.40980238
34Autoimmune thyroid disease_Homo sapiens_hsa053201.35652663
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.28677323
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27706179
37Fatty acid metabolism_Homo sapiens_hsa012121.27031962
38Cardiac muscle contraction_Homo sapiens_hsa042601.24410917
39Huntingtons disease_Homo sapiens_hsa050161.21355683
40Type I diabetes mellitus_Homo sapiens_hsa049401.20287566
41Phenylalanine metabolism_Homo sapiens_hsa003601.19705812
42Fat digestion and absorption_Homo sapiens_hsa049751.18769554
43Antigen processing and presentation_Homo sapiens_hsa046121.17155273
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.15762684
45Fatty acid degradation_Homo sapiens_hsa000711.15312866
46Mineral absorption_Homo sapiens_hsa049781.12602103
47Carbon metabolism_Homo sapiens_hsa012001.12098509
48Graft-versus-host disease_Homo sapiens_hsa053321.08296283
49Mismatch repair_Homo sapiens_hsa034301.07589780
50Renin secretion_Homo sapiens_hsa049241.05554926
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04616288
52Type II diabetes mellitus_Homo sapiens_hsa049301.04402819
53Purine metabolism_Homo sapiens_hsa002301.02841245
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96253079
55Arginine biosynthesis_Homo sapiens_hsa002200.95585452
56Hedgehog signaling pathway_Homo sapiens_hsa043400.95543879
57Gap junction_Homo sapiens_hsa045400.94332297
58Influenza A_Homo sapiens_hsa051640.92965028
59Nucleotide excision repair_Homo sapiens_hsa034200.90569603
60Circadian rhythm_Homo sapiens_hsa047100.88582803
61Viral myocarditis_Homo sapiens_hsa054160.86101989
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85681185
63Estrogen signaling pathway_Homo sapiens_hsa049150.84585602
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82412978
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78399849
66Arachidonic acid metabolism_Homo sapiens_hsa005900.77798207
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73271720
68Nicotine addiction_Homo sapiens_hsa050330.73246289
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71920706
70Arginine and proline metabolism_Homo sapiens_hsa003300.71155865
71Long-term potentiation_Homo sapiens_hsa047200.70887660
72Insulin secretion_Homo sapiens_hsa049110.69623761
73Biosynthesis of amino acids_Homo sapiens_hsa012300.68999615
74Legionellosis_Homo sapiens_hsa051340.67010327
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.66685355
76Morphine addiction_Homo sapiens_hsa050320.66558417
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65513684
78ABC transporters_Homo sapiens_hsa020100.65110308
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63116125
80Glutathione metabolism_Homo sapiens_hsa004800.62952037
81Herpes simplex infection_Homo sapiens_hsa051680.61572458
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60514393
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.60279702
84Inositol phosphate metabolism_Homo sapiens_hsa005620.58981438
85Calcium signaling pathway_Homo sapiens_hsa040200.58467647
86Protein digestion and absorption_Homo sapiens_hsa049740.56093913
87Thyroid hormone synthesis_Homo sapiens_hsa049180.55656275
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55350364
89Taste transduction_Homo sapiens_hsa047420.55257765
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54612074
91Bile secretion_Homo sapiens_hsa049760.52169131
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50508664
93AMPK signaling pathway_Homo sapiens_hsa041520.50279341
94Endocytosis_Homo sapiens_hsa041440.47887759
95VEGF signaling pathway_Homo sapiens_hsa043700.45753448
96Chemical carcinogenesis_Homo sapiens_hsa052040.44959929
97Renin-angiotensin system_Homo sapiens_hsa046140.44453801
98mTOR signaling pathway_Homo sapiens_hsa041500.43748916
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43639171
100Pancreatic secretion_Homo sapiens_hsa049720.42893516
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.41607599
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41354282
103Collecting duct acid secretion_Homo sapiens_hsa049660.41219474
104Cell cycle_Homo sapiens_hsa041100.40466606
105Nitrogen metabolism_Homo sapiens_hsa009100.40189789
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38934394
107Pyrimidine metabolism_Homo sapiens_hsa002400.38675588
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38669242
109MAPK signaling pathway_Homo sapiens_hsa040100.38356991
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38120143
111cAMP signaling pathway_Homo sapiens_hsa040240.37029840
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.36216883
113Gastric acid secretion_Homo sapiens_hsa049710.36133837
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35972935
115Retinol metabolism_Homo sapiens_hsa008300.35661944
116Phototransduction_Homo sapiens_hsa047440.35463073
117Serotonergic synapse_Homo sapiens_hsa047260.35363416
118Tyrosine metabolism_Homo sapiens_hsa003500.35047518
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34724776
120DNA replication_Homo sapiens_hsa030300.33400150
121Salivary secretion_Homo sapiens_hsa049700.32392103
122Homologous recombination_Homo sapiens_hsa034400.30814271
123Adherens junction_Homo sapiens_hsa045200.30404694
124RNA degradation_Homo sapiens_hsa030180.29633887
125Glutamatergic synapse_Homo sapiens_hsa047240.29107737
126Regulation of autophagy_Homo sapiens_hsa041400.28452925
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28216803
128Basal cell carcinoma_Homo sapiens_hsa052170.27132714
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.26905821
130Metabolic pathways_Homo sapiens_hsa011000.26742219
131TGF-beta signaling pathway_Homo sapiens_hsa043500.25740047
132Synaptic vesicle cycle_Homo sapiens_hsa047210.23535256
133Acute myeloid leukemia_Homo sapiens_hsa052210.23531883
134Circadian entrainment_Homo sapiens_hsa047130.23285625
135Oxytocin signaling pathway_Homo sapiens_hsa049210.22834420
136Wnt signaling pathway_Homo sapiens_hsa043100.22351353
137Systemic lupus erythematosus_Homo sapiens_hsa053220.21446783
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20387950
139Base excision repair_Homo sapiens_hsa034100.18215929
140Viral carcinogenesis_Homo sapiens_hsa052030.18013225
141Cocaine addiction_Homo sapiens_hsa050300.17322233
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12251612
143Ovarian steroidogenesis_Homo sapiens_hsa049130.11703071
144Alcoholism_Homo sapiens_hsa050340.11581699

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