SOX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.34618678
2pyrimidine nucleobase catabolic process (GO:0006208)5.11482631
3presynaptic membrane organization (GO:0097090)4.86459357
4cell migration in hindbrain (GO:0021535)4.53434033
5behavioral response to nicotine (GO:0035095)4.20215926
6vocalization behavior (GO:0071625)3.97265204
7somite development (GO:0061053)3.85543944
8protein localization to cilium (GO:0061512)3.83759132
9central nervous system projection neuron axonogenesis (GO:0021952)3.82140095
10cranial nerve morphogenesis (GO:0021602)3.73465620
11nucleosome disassembly (GO:0006337)3.72422322
12protein-DNA complex disassembly (GO:0032986)3.72422322
13sequestering of actin monomers (GO:0042989)3.71356203
14nucleobase catabolic process (GO:0046113)3.64304010
15cornea development in camera-type eye (GO:0061303)3.63897545
16neuronal stem cell maintenance (GO:0097150)3.62262029
17layer formation in cerebral cortex (GO:0021819)3.55417004
18dendritic spine morphogenesis (GO:0060997)3.51223218
19behavioral response to ethanol (GO:0048149)3.50640472
20regulation of timing of cell differentiation (GO:0048505)3.49455391
21cerebral cortex radially oriented cell migration (GO:0021799)3.46357577
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.46110282
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.46110282
24regulation of translation, ncRNA-mediated (GO:0045974)3.46110282
25dopaminergic neuron differentiation (GO:0071542)3.45340372
26axonal fasciculation (GO:0007413)3.42595039
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42082724
28synapse assembly (GO:0007416)3.33952977
29olfactory bulb development (GO:0021772)3.33707626
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32855721
31proximal/distal pattern formation (GO:0009954)3.30525706
32negative regulation of axon guidance (GO:1902668)3.30347695
33negative regulation of RNA splicing (GO:0033119)3.29967013
34* neural tube formation (GO:0001841)3.28330388
35neuron recognition (GO:0008038)3.26542051
36DNA double-strand break processing (GO:0000729)3.25135393
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25049559
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24937169
39negative regulation of oligodendrocyte differentiation (GO:0048715)3.24886063
40negative regulation of transcription regulatory region DNA binding (GO:2000678)3.17418073
41lateral sprouting from an epithelium (GO:0060601)3.16219117
42gastrulation with mouth forming second (GO:0001702)3.15780240
43regulation of collateral sprouting (GO:0048670)3.13109221
44dendrite morphogenesis (GO:0048813)3.11491866
45metanephric mesenchyme development (GO:0072075)3.11055249
46central nervous system neuron axonogenesis (GO:0021955)3.10328783
47neurotransmitter-gated ion channel clustering (GO:0072578)3.09775378
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08694090
49generation of neurons (GO:0048699)3.08470691
50neuron cell-cell adhesion (GO:0007158)3.08261482
51negative regulation of axon extension involved in axon guidance (GO:0048843)3.07789279
52gamma-aminobutyric acid transport (GO:0015812)3.07309027
53negative regulation of axon extension (GO:0030517)3.04994055
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.04817803
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02694475
56mRNA splice site selection (GO:0006376)3.02052838
57protein-cofactor linkage (GO:0018065)3.00075676
58* limb bud formation (GO:0060174)2.94747466
59cell proliferation in forebrain (GO:0021846)2.93808886
60glutamate receptor signaling pathway (GO:0007215)2.93716384
61axon extension (GO:0048675)2.91858336
62mechanosensory behavior (GO:0007638)2.91450386
63negative regulation of dendrite development (GO:2000171)2.91157230
64ganglion development (GO:0061548)2.90781877
65regulation of axon guidance (GO:1902667)2.88238635
66kidney mesenchyme development (GO:0072074)2.88122512
67lens morphogenesis in camera-type eye (GO:0002089)2.87266544
68intraciliary transport (GO:0042073)2.87253414
69facial nerve structural organization (GO:0021612)2.87072930
70negative regulation of catenin import into nucleus (GO:0035414)2.86439816
71regulation of mRNA splicing, via spliceosome (GO:0048024)2.84897589
72urogenital system development (GO:0001655)2.84671921
73viral transcription (GO:0019083)2.84113986
74positive regulation of synapse assembly (GO:0051965)2.83936796
75positive regulation of neuroblast proliferation (GO:0002052)2.82237031
76regulation of telomere maintenance (GO:0032204)2.81231254
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80998908
78postsynaptic membrane organization (GO:0001941)2.80420486
79transmission of nerve impulse (GO:0019226)2.80121081
80* spinal cord development (GO:0021510)2.77427060
81establishment of mitochondrion localization (GO:0051654)2.75681853
82axon extension involved in axon guidance (GO:0048846)2.75077248
83neuron projection extension involved in neuron projection guidance (GO:1902284)2.75077248
84hippocampus development (GO:0021766)2.75030026
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.74526001
86DNA topological change (GO:0006265)2.74163512
87glomerulus development (GO:0032835)2.73288011
88forebrain neuron differentiation (GO:0021879)2.71099929
89negative regulation of mRNA processing (GO:0050686)2.70562001
90nonmotile primary cilium assembly (GO:0035058)2.70495781
91neuron migration (GO:0001764)2.69828457
92histone H2A acetylation (GO:0043968)2.69610668
93regulation of axon extension involved in axon guidance (GO:0048841)2.69089044
94head development (GO:0060322)2.68347678
95cochlea morphogenesis (GO:0090103)2.67427719
96establishment of planar polarity (GO:0001736)2.66863297
97establishment of tissue polarity (GO:0007164)2.66863297
98* sympathetic nervous system development (GO:0048485)2.66046159
99nephron tubule development (GO:0072080)2.65704391
100protein localization to synapse (GO:0035418)2.65656267
101auditory behavior (GO:0031223)2.62991219
102translational termination (GO:0006415)2.61466539
103semaphorin-plexin signaling pathway (GO:0071526)2.60439627
104regulation of meiosis I (GO:0060631)2.60223028
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57784230
106hindbrain development (GO:0030902)2.57380613
107eyelid development in camera-type eye (GO:0061029)2.57298033
108hippo signaling (GO:0035329)2.57292171
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57209460
110neuronal action potential (GO:0019228)2.57076401
111positive regulation of gastrulation (GO:2000543)2.56518137
112RNA localization (GO:0006403)2.56180535
113cilium morphogenesis (GO:0060271)2.55540169
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.54633622
115alternative mRNA splicing, via spliceosome (GO:0000380)2.54522591
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53818317
117somite rostral/caudal axis specification (GO:0032525)2.53808356
118respiratory tube development (GO:0030323)2.53606947
119replication fork processing (GO:0031297)2.51732655
120germ cell migration (GO:0008354)2.51196907
121atrial cardiac muscle cell action potential (GO:0086014)2.49266199
122startle response (GO:0001964)2.48952106
123microtubule depolymerization (GO:0007019)2.48926435
124synaptic transmission, cholinergic (GO:0007271)2.48455559
125positive regulation of amino acid transport (GO:0051957)2.48211987
126retinal ganglion cell axon guidance (GO:0031290)2.48174462
127central nervous system neuron development (GO:0021954)2.48028748
128cell differentiation involved in kidney development (GO:0061005)2.47885198
129spinal cord association neuron differentiation (GO:0021527)2.47016143
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46016150
131reflex (GO:0060004)2.46001199
132retinal cone cell development (GO:0046549)2.45877305
133embryonic foregut morphogenesis (GO:0048617)2.45265281
134nephron epithelium development (GO:0072009)2.44766072
135inner ear receptor stereocilium organization (GO:0060122)2.44673276
136platelet dense granule organization (GO:0060155)2.44152202
137neuron fate specification (GO:0048665)2.43982539
138negative regulation of epidermal cell differentiation (GO:0045605)2.43418115
139neuronal action potential propagation (GO:0019227)2.43126986
140positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.42851150
141peptidyl-arginine methylation (GO:0018216)2.42583534
142peptidyl-arginine N-methylation (GO:0035246)2.42583534
143regulation of hexokinase activity (GO:1903299)2.42134969
144regulation of glucokinase activity (GO:0033131)2.42134969
145cerebral cortex cell migration (GO:0021795)2.41971237
146regulation of oligodendrocyte differentiation (GO:0048713)2.41067310
147C4-dicarboxylate transport (GO:0015740)2.41059902
148synaptic transmission, glutamatergic (GO:0035249)2.40131372
149epithelial cilium movement (GO:0003351)2.39425042
150negative regulation of telomere maintenance (GO:0032205)2.39378130
151epithelial cell differentiation involved in kidney development (GO:0035850)2.38129952
152glycosphingolipid biosynthetic process (GO:0006688)2.37534160
153response to pheromone (GO:0019236)2.37353498
154DNA integration (GO:0015074)2.36877514
155regulation of action potential (GO:0098900)2.36877468
156regulation of development, heterochronic (GO:0040034)2.36855979
157positive regulation of RNA splicing (GO:0033120)2.36742238
158negative regulation of microtubule polymerization (GO:0031115)2.35953416
159negative regulation of epidermis development (GO:0045683)2.35744058
160regulation of dendritic spine morphogenesis (GO:0061001)2.35621127
161regulation of feeding behavior (GO:0060259)2.35506834
162renal tubule development (GO:0061326)2.34744698
163synapse organization (GO:0050808)2.34128978
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.32701074
165regulation of synapse assembly (GO:0051963)2.32646126
166negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32580868
167protein complex disassembly (GO:0043241)2.32455020
168neuron fate commitment (GO:0048663)2.32361166
169regulation of neuron migration (GO:2001222)2.31811590
170regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31191077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61564897
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.99103014
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.58119992
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.32817471
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.30593464
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95907783
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.92621867
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89036884
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83873802
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.80942645
11* CBX2_27304074_Chip-Seq_ESCs_Mouse2.77435943
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64423705
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61844001
14VDR_22108803_ChIP-Seq_LS180_Human2.57929663
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.55069305
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.50272190
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.45600533
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42778634
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42778634
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.39637151
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34048690
22TAF15_26573619_Chip-Seq_HEK293_Human2.33349784
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24844481
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18589252
25* P300_19829295_ChIP-Seq_ESCs_Human2.18232689
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17218568
27* RING1B_27294783_Chip-Seq_NPCs_Mouse2.15923802
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13054835
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07869363
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07446864
31* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98523440
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96398809
33* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93980113
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.92858201
35* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92351246
36* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92208339
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.90756847
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.83597501
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83383364
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82154480
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82104841
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79740231
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.76846428
44* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75389217
45RNF2_27304074_Chip-Seq_NSC_Mouse1.73044005
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70251901
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.69880094
48* REST_21632747_ChIP-Seq_MESCs_Mouse1.69321562
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67370884
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64742816
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64053148
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.63936897
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.62523036
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62185561
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.61996938
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61411268
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61201254
58SMAD4_21799915_ChIP-Seq_A2780_Human1.60951117
59* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59380619
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56251511
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55780264
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54588965
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54002493
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51420242
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49620029
66ER_23166858_ChIP-Seq_MCF-7_Human1.49176447
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47438024
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47136686
69* ISL1_27105846_Chip-Seq_CPCs_Mouse1.46445444
70* AR_25329375_ChIP-Seq_VCAP_Human1.44552435
71ZNF274_21170338_ChIP-Seq_K562_Hela1.43013386
72CBP_20019798_ChIP-Seq_JUKART_Human1.42918434
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42918434
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39355901
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.38123692
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35351205
77BCAT_22108803_ChIP-Seq_LS180_Human1.35309118
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34495316
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31968277
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31763523
81STAT3_23295773_ChIP-Seq_U87_Human1.28598273
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27302361
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26668978
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26418129
85* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26121238
86* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26071135
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.24127942
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22488289
89* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22306837
90TCF4_23295773_ChIP-Seq_U87_Human1.19787343
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19163175
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18177771
93* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18155352
94* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18155352
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.18106898
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17411290
97AR_21572438_ChIP-Seq_LNCaP_Human1.16629711
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.16609609
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15322316
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14558267
101* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14368138
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.14325426
103GBX2_23144817_ChIP-Seq_PC3_Human1.13928479
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12285312
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11313835
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.10471996
107FUS_26573619_Chip-Seq_HEK293_Human1.10150730
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10040966
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09307740
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09168231
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09081533
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.08930702
113* TCF4_22108803_ChIP-Seq_LS180_Human1.06442800
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.06176919
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05507075
116* SOX9_26525672_Chip-Seq_HEART_Mouse1.05157026
117* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04843087
118MYC_18940864_ChIP-ChIP_HL60_Human1.04615923
119ELK1_19687146_ChIP-ChIP_HELA_Human1.04475630
120IRF1_19129219_ChIP-ChIP_H3396_Human1.04411046
121TP63_17297297_ChIP-ChIP_HaCaT_Human1.04052633
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.03169418
123PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01592900
124SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01316325
125TP53_22573176_ChIP-Seq_HFKS_Human1.01293897
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00630895
127AHR_22903824_ChIP-Seq_MCF-7_Human1.00537341
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.99194965
129* KDM2B_26808549_Chip-Seq_K562_Human0.99090325
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98745050
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97822351
132NANOG_19829295_ChIP-Seq_ESCs_Human0.97009024
133SOX2_19829295_ChIP-Seq_ESCs_Human0.97009024
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.95170411
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94963560
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94740977
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94534802
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94452220
139P53_22387025_ChIP-Seq_ESCs_Mouse0.94316010
140POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.93138731
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92359926
142IGF1R_20145208_ChIP-Seq_DFB_Human0.92207015
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92086532
144TP53_18474530_ChIP-ChIP_U2OS_Human0.91848455
145* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91738775
146* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91523557
147* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90692609
148EWS_26573619_Chip-Seq_HEK293_Human0.89470188
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89430054
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88670895
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.88032902
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87005975
153SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83222208
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.83055555
155* SMAD3_21741376_ChIP-Seq_EPCs_Human0.82601743
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81837303
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81480094
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81418198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.25414201
2MP0000778_abnormal_nervous_system2.85274993
3MP0009379_abnormal_foot_pigmentation2.77285864
4MP0001529_abnormal_vocalization2.60075878
5MP0000049_abnormal_middle_ear2.49501645
6MP0002736_abnormal_nociception_after2.49493888
7MP0008789_abnormal_olfactory_epithelium2.46045590
8MP0003385_abnormal_body_wall2.42754872
9MP0010030_abnormal_orbit_morphology2.39771768
10MP0002735_abnormal_chemical_nociception2.18953747
11MP0000569_abnormal_digit_pigmentation2.18178333
12MP0002102_abnormal_ear_morphology2.17672432
13MP0001968_abnormal_touch/_nociception2.16963552
14MP0006292_abnormal_olfactory_placode2.06618525
15MP0003787_abnormal_imprinting2.05388926
16MP0001984_abnormal_olfaction2.00829363
17MP0003315_abnormal_perineum_morphology2.00271618
18MP0002822_catalepsy1.96592431
19MP0009053_abnormal_anal_canal1.93444979
20MP0003938_abnormal_ear_development1.90678840
21MP0009250_abnormal_appendicular_skeleto1.87008109
22MP0003937_abnormal_limbs/digits/tail_de1.85683413
23MP0003755_abnormal_palate_morphology1.79483503
24MP0002938_white_spotting1.78754471
25MP0003942_abnormal_urinary_system1.78509035
26MP0003635_abnormal_synaptic_transmissio1.74755486
27MP0003119_abnormal_digestive_system1.74194387
28MP0009745_abnormal_behavioral_response1.74085098
29MP0000566_synostosis1.72865424
30MP0002234_abnormal_pharynx_morphology1.72491835
31MP0002734_abnormal_mechanical_nocicepti1.71284662
32MP0008877_abnormal_DNA_methylation1.71183850
33* MP0003861_abnormal_nervous_system1.70966451
34MP0005499_abnormal_olfactory_system1.68117730
35MP0005394_taste/olfaction_phenotype1.68117730
36* MP0002751_abnormal_autonomic_nervous1.66823378
37MP0000631_abnormal_neuroendocrine_gland1.66131676
38MP0005248_abnormal_Harderian_gland1.65037069
39MP0001486_abnormal_startle_reflex1.63737804
40MP0003121_genomic_imprinting1.62985990
41MP0005551_abnormal_eye_electrophysiolog1.60426306
42MP0002249_abnormal_larynx_morphology1.60120530
43MP0002653_abnormal_ependyma_morphology1.59013411
44MP0002272_abnormal_nervous_system1.58075744
45MP0002116_abnormal_craniofacial_bone1.57954998
46MP0003935_abnormal_craniofacial_develop1.57533952
47MP0002233_abnormal_nose_morphology1.55608728
48MP0004859_abnormal_synaptic_plasticity1.53373355
49MP0009046_muscle_twitch1.52664600
50MP0000428_abnormal_craniofacial_morphol1.52119037
51MP0002638_abnormal_pupillary_reflex1.49949096
52MP0003890_abnormal_embryonic-extraembry1.47747088
53MP0004924_abnormal_behavior1.47539890
54MP0005386_behavior/neurological_phenoty1.47539890
55MP0003283_abnormal_digestive_organ1.47298475
56MP0002572_abnormal_emotion/affect_behav1.47049477
57MP0002063_abnormal_learning/memory/cond1.46128443
58MP0005253_abnormal_eye_physiology1.41614875
59MP0003115_abnormal_respiratory_system1.37993614
60MP0001286_abnormal_eye_development1.37992418
61MP0002064_seizures1.37158554
62MP0005367_renal/urinary_system_phenotyp1.37089921
63MP0000516_abnormal_urinary_system1.37089921
64MP0005423_abnormal_somatic_nervous1.36504345
65MP0002177_abnormal_outer_ear1.36207339
66MP0002184_abnormal_innervation1.35343276
67MP0002932_abnormal_joint_morphology1.34228817
68MP0005623_abnormal_meninges_morphology1.33047158
69MP0005187_abnormal_penis_morphology1.31186541
70MP0008058_abnormal_DNA_repair1.31069112
71MP0000534_abnormal_ureter_morphology1.30459290
72MP0008995_early_reproductive_senescence1.27192025
73MP0002067_abnormal_sensory_capabilities1.27085491
74MP0002081_perinatal_lethality1.26907073
75MP0003122_maternal_imprinting1.26742814
76MP0002697_abnormal_eye_size1.23591194
77MP0005503_abnormal_tendon_morphology1.22577063
78MP0000733_abnormal_muscle_development1.22447140
79MP0004133_heterotaxia1.22229680
80MP0000462_abnormal_digestive_system1.20721119
81MP0005257_abnormal_intraocular_pressure1.19494490
82* MP0002282_abnormal_trachea_morphology1.18678494
83MP0002092_abnormal_eye_morphology1.16982137
84MP0004134_abnormal_chest_morphology1.16356799
85MP0000647_abnormal_sebaceous_gland1.15925698
86MP0001188_hyperpigmentation1.15877428
87MP0001970_abnormal_pain_threshold1.15739341
88MP0003567_abnormal_fetal_cardiomyocyte1.14896999
89MP0001879_abnormal_lymphatic_vessel1.13935745
90MP0000432_abnormal_head_morphology1.12918425
91MP0002152_abnormal_brain_morphology1.12782050
92MP0000026_abnormal_inner_ear1.11851184
93MP0001177_atelectasis1.10752239
94MP0005409_darkened_coat_color1.10258817
95MP0004142_abnormal_muscle_tone1.06743469
96MP0002733_abnormal_thermal_nociception1.06573853
97MP0003880_abnormal_central_pattern1.06256689
98MP0004742_abnormal_vestibular_system1.04973248
99MP0002114_abnormal_axial_skeleton1.04849107
100MP0000955_abnormal_spinal_cord1.04047578
101MP0006276_abnormal_autonomic_nervous1.03978241
102MP0005195_abnormal_posterior_eye1.02704738
103MP0001299_abnormal_eye_distance/1.02605881
104MP0000762_abnormal_tongue_morphology1.00219856
105MP0002084_abnormal_developmental_patter0.99626146
106MP0003011_delayed_dark_adaptation0.97667951
107MP0003718_maternal_effect0.97587163
108MP0002085_abnormal_embryonic_tissue0.95961970
109MP0005645_abnormal_hypothalamus_physiol0.95668228
110MP0008007_abnormal_cellular_replicative0.94156661
111MP0001485_abnormal_pinna_reflex0.93316288
112MP0002557_abnormal_social/conspecific_i0.93310704
113MP0001293_anophthalmia0.93065125
114MP0002111_abnormal_tail_morphology0.91758359
115MP0008872_abnormal_physiological_respon0.91716300
116MP0005646_abnormal_pituitary_gland0.91390316
117MP0004197_abnormal_fetal_growth/weight/0.90194677
118MP0001346_abnormal_lacrimal_gland0.90122437
119MP0004043_abnormal_pH_regulation0.89579960
120MP0002069_abnormal_eating/drinking_beha0.89469503
121MP0004811_abnormal_neuron_physiology0.89389975
122MP0001340_abnormal_eyelid_morphology0.89062053
123MP0008438_abnormal_cutaneous_collagen0.88970657
124MP0005508_abnormal_skeleton_morphology0.88733107
125MP0004858_abnormal_nervous_system0.88685379
126MP0003136_yellow_coat_color0.88420268
127MP0002882_abnormal_neuron_morphology0.87246676
128MP0002752_abnormal_somatic_nervous0.86132616
129MP0003137_abnormal_impulse_conducting0.85865028
130MP0004885_abnormal_endolymph0.83697334
131MP0001270_distended_abdomen0.83659314
132MP0006072_abnormal_retinal_apoptosis0.82880883
133MP0009384_cardiac_valve_regurgitation0.82426544
134MP0002066_abnormal_motor_capabilities/c0.81160462
135MP0000372_irregular_coat_pigmentation0.80717988
136MP0005076_abnormal_cell_differentiation0.79491639
137MP0005084_abnormal_gallbladder_morpholo0.79079340
138MP0001849_ear_inflammation0.78201035
139MP0002109_abnormal_limb_morphology0.78199421
140MP0001986_abnormal_taste_sensitivity0.77544111
141MP0005174_abnormal_tail_pigmentation0.77333755
142MP0002095_abnormal_skin_pigmentation0.77282567
143MP0002928_abnormal_bile_duct0.75562521
144MP0003698_abnormal_male_reproductive0.75479074
145MP0005391_vision/eye_phenotype0.74131481
146MP0004270_analgesia0.72664158
147MP0008932_abnormal_embryonic_tissue0.70551414

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.64867347
2Abnormality of the labia minora (HP:0012880)3.64713504
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.52299501
4Short 4th metacarpal (HP:0010044)3.52299501
5Pancreatic cysts (HP:0001737)3.26632753
6Morphological abnormality of the middle ear (HP:0008609)3.25728379
7True hermaphroditism (HP:0010459)3.16192362
8Asymmetry of the thorax (HP:0001555)3.10825128
9Absent speech (HP:0001344)3.10565306
10Hepatoblastoma (HP:0002884)3.06093661
11Nephronophthisis (HP:0000090)3.01464816
12Focal motor seizures (HP:0011153)3.00743835
13Abnormality of the 4th metacarpal (HP:0010012)2.99708136
14Pancreatic fibrosis (HP:0100732)2.97781365
15Abnormality of midbrain morphology (HP:0002418)2.94841648
16Molar tooth sign on MRI (HP:0002419)2.94841648
17Germ cell neoplasia (HP:0100728)2.92949565
18Broad-based gait (HP:0002136)2.89263221
19Abnormality of the intervertebral disk (HP:0005108)2.87592879
20Hyperacusis (HP:0010780)2.78610375
21Intestinal atresia (HP:0011100)2.71642954
22Abnormality of the renal medulla (HP:0100957)2.67168779
23Renal duplication (HP:0000075)2.64366786
24Colon cancer (HP:0003003)2.58214505
25Focal seizures (HP:0007359)2.48539301
26Oligodactyly (hands) (HP:0001180)2.48043566
27Shallow orbits (HP:0000586)2.46748671
28Pendular nystagmus (HP:0012043)2.46043895
29Inability to walk (HP:0002540)2.45973239
30Retinal dysplasia (HP:0007973)2.43059892
31Pachygyria (HP:0001302)2.34283412
32Cortical dysplasia (HP:0002539)2.34259625
33Medial flaring of the eyebrow (HP:0010747)2.33712970
34Cupped ear (HP:0000378)2.33356268
35Elfin facies (HP:0004428)2.30340957
36Chin dimple (HP:0010751)2.30226750
37Congenital stationary night blindness (HP:0007642)2.29605684
38Gait imbalance (HP:0002141)2.27988886
39Neoplasm of the adrenal cortex (HP:0100641)2.27650305
40Febrile seizures (HP:0002373)2.26394648
41Spina bifida occulta (HP:0003298)2.26311208
42Abnormality of the renal cortex (HP:0011035)2.23871698
43Thyroid-stimulating hormone excess (HP:0002925)2.22662129
44Type II lissencephaly (HP:0007260)2.22464784
45Anencephaly (HP:0002323)2.21205047
46Subacute progressive viral hepatitis (HP:0006572)2.18306851
47High anterior hairline (HP:0009890)2.17249622
48Chronic hepatic failure (HP:0100626)2.16104572
49Progressive inability to walk (HP:0002505)2.12980289
50Cystic liver disease (HP:0006706)2.11854125
51Narrow forehead (HP:0000341)2.11199334
52Exotropia (HP:0000577)2.10887211
53Optic nerve hypoplasia (HP:0000609)2.10496588
54Genital tract atresia (HP:0001827)2.10197437
55Lissencephaly (HP:0001339)2.10018569
56Midline defect of the nose (HP:0004122)2.09246556
57Overriding aorta (HP:0002623)2.09057496
58Lymphangioma (HP:0100764)2.07948358
59Overgrowth (HP:0001548)2.05933304
60Protruding tongue (HP:0010808)2.05375311
61Flat cornea (HP:0007720)2.04526581
62Renovascular hypertension (HP:0100817)2.04018363
63Vaginal atresia (HP:0000148)2.03968518
64Widely spaced teeth (HP:0000687)2.02679221
65Renal cortical cysts (HP:0000803)2.02380603
66Limb dystonia (HP:0002451)2.01686574
67Hypothermia (HP:0002045)2.01508482
68Scrotal hypoplasia (HP:0000046)2.00385307
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00322846
70Congenital primary aphakia (HP:0007707)1.99835412
71Postaxial hand polydactyly (HP:0001162)1.99501974
72Broad ribs (HP:0000885)1.99122118
73Nephrogenic diabetes insipidus (HP:0009806)1.98825624
74Dandy-Walker malformation (HP:0001305)1.98246035
75Hip dysplasia (HP:0001385)1.95138238
76Abolished electroretinogram (ERG) (HP:0000550)1.93015565
77Sclerocornea (HP:0000647)1.92809585
78Epileptic encephalopathy (HP:0200134)1.92375493
79Wrist flexion contracture (HP:0001239)1.92079090
80Abnormality of the aortic arch (HP:0012303)1.91625185
81Short philtrum (HP:0000322)1.91619088
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.91245991
83Tented upper lip vermilion (HP:0010804)1.91220499
84Patellar dislocation (HP:0002999)1.90127361
85Down-sloping shoulders (HP:0200021)1.89939156
86Exostoses (HP:0100777)1.89232282
87Abnormality of the diencephalon (HP:0010662)1.88614978
88Sacral dimple (HP:0000960)1.88307905
89Renal hypoplasia (HP:0000089)1.88155952
90Hemiparesis (HP:0001269)1.87840914
91Shoulder girdle muscle weakness (HP:0003547)1.87281808
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86329575
93Vesicoureteral reflux (HP:0000076)1.86254010
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.86058315
95Atonic seizures (HP:0010819)1.85804793
96Anophthalmia (HP:0000528)1.85423112
97Buphthalmos (HP:0000557)1.84968384
98Preaxial hand polydactyly (HP:0001177)1.82630587
99Obstructive sleep apnea (HP:0002870)1.82043077
100Increased nuchal translucency (HP:0010880)1.81651027
101Bladder diverticulum (HP:0000015)1.81564049
102Heterochromia iridis (HP:0001100)1.80918214
103Small hand (HP:0200055)1.80596667
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.79258723
105Split foot (HP:0001839)1.78778571
106Facial hemangioma (HP:0000329)1.78357363
107Coronal craniosynostosis (HP:0004440)1.77251643
108Increased number of teeth (HP:0011069)1.76853142
109Deviation of the hallux (HP:0010051)1.76285933
110Patellar aplasia (HP:0006443)1.75601476
111Postaxial foot polydactyly (HP:0001830)1.75030486
112Aqueductal stenosis (HP:0002410)1.73169760
113Abnormality of the parathyroid morphology (HP:0011766)1.72992667
114Progressive cerebellar ataxia (HP:0002073)1.72975592
115Bowel diverticulosis (HP:0005222)1.72798745
116Increased corneal curvature (HP:0100692)1.72777182
117Keratoconus (HP:0000563)1.72777182
118Cutis marmorata (HP:0000965)1.72427497
119Dialeptic seizures (HP:0011146)1.72312405
120Abnormality of the pubic bones (HP:0003172)1.72118621
121Abnormality of the astrocytes (HP:0100707)1.72099177
122Astrocytoma (HP:0009592)1.72099177
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.71572466
124Glioma (HP:0009733)1.71519484
125Gastroesophageal reflux (HP:0002020)1.71499291
126Gastrointestinal atresia (HP:0002589)1.70486995
127Labial hypoplasia (HP:0000066)1.70301157
128Hallux valgus (HP:0001822)1.70245686
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70218406
130Hypoplasia of the brainstem (HP:0002365)1.70218406
131Male pseudohermaphroditism (HP:0000037)1.70056643
132Aplasia/Hypoplasia of the patella (HP:0006498)1.69912529
133Septo-optic dysplasia (HP:0100842)1.69470221
134Supernumerary spleens (HP:0009799)1.68528230
135Polyphagia (HP:0002591)1.68388040
136Abnormality of hair growth rate (HP:0011363)1.68291490
137Slow-growing hair (HP:0002217)1.68291490
138Transitional cell carcinoma of the bladder (HP:0006740)1.68230398
139Ependymoma (HP:0002888)1.68171764
140Large eyes (HP:0001090)1.67950933
141Gaze-evoked nystagmus (HP:0000640)1.67806310
142Bilateral microphthalmos (HP:0007633)1.67720493
143Short tibia (HP:0005736)1.67087033
144Acute necrotizing encephalopathy (HP:0006965)1.66395315
145Reticulocytopenia (HP:0001896)1.66081389
146Megalencephaly (HP:0001355)1.65543012
147Tubulointerstitial nephritis (HP:0001970)1.65381669
148Micropenis (HP:0000054)1.65226108
149Abnormality of the phalanges of the hallux (HP:0010057)1.65188347
150Leiomyosarcoma (HP:0100243)1.65091260
151Uterine leiomyosarcoma (HP:0002891)1.65091260
152Megalocornea (HP:0000485)1.64374809
153Sporadic (HP:0003745)1.63853828
154Esotropia (HP:0000565)1.63627807
155Volvulus (HP:0002580)1.63590187
156Shawl scrotum (HP:0000049)1.63497869
157Bladder neoplasm (HP:0009725)1.62964553
158Bladder carcinoma (HP:0002862)1.62964553
159Acute lymphatic leukemia (HP:0006721)1.62243113
160Cutaneous finger syndactyly (HP:0010554)1.62179782
161Wide anterior fontanel (HP:0000260)1.61820793
162Esophageal atresia (HP:0002032)1.61813125
163Thick lower lip vermilion (HP:0000179)1.61762244
164Abnormality of the metopic suture (HP:0005556)1.61745429
165Arnold-Chiari malformation (HP:0002308)1.61518920
166Medulloblastoma (HP:0002885)1.59414381
167Myelomeningocele (HP:0002475)1.58678113
168Omphalocele (HP:0001539)1.56821135
169Embryonal neoplasm (HP:0002898)1.56505541
170Supernumerary ribs (HP:0005815)1.55391124
171Drooling (HP:0002307)1.55157787
172Excessive salivation (HP:0003781)1.55157787
173Broad alveolar ridges (HP:0000187)1.54703179
174Oligodactyly (HP:0012165)1.53409307
175Autism (HP:0000717)1.53213957
176Obsessive-compulsive behavior (HP:0000722)1.52527715
177Increased density of long bones (HP:0006392)1.50581184
178Congenital diaphragmatic hernia (HP:0000776)1.48402920
179Abnormality of the parietal bone (HP:0002696)1.48372354
180Atresia of the external auditory canal (HP:0000413)1.48032036
181Thick eyebrow (HP:0000574)1.47795463
182Intellectual disability, moderate (HP:0002342)1.47636221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.22149899
2EPHB23.84404365
3WNK33.57064034
4DYRK22.97029742
5MAPK132.91702833
6MKNK22.78811735
7MKNK12.77978559
8FRK2.71154935
9ERBB32.66604855
10MAP4K22.53280378
11TRIM282.41069826
12DYRK32.28524206
13MAP3K102.25599715
14SIK22.21230256
15CASK2.16375324
16ICK1.96109703
17TGFBR11.93312065
18EPHA41.92355932
19SRPK11.79013434
20UHMK11.75006549
21TNIK1.66808615
22EEF2K1.65536257
23DYRK1B1.62273488
24CSNK1A1L1.60366698
25CSNK1G31.60297937
26LIMK11.54578568
27BMPR1B1.54392290
28INSRR1.49881676
29CSNK1G11.44514101
30TYRO31.43370361
31ZAK1.39275945
32KSR11.38324964
33NTRK21.34631007
34ADRBK21.34467242
35ACVR1B1.34155220
36TRIB31.31000799
37PKN21.30146770
38GRK11.25663491
39CSNK1G21.24316719
40TLK11.19399901
41ILK1.16869339
42PTK61.13953099
43PDGFRA1.08418149
44PINK11.06198215
45MINK11.05841832
46VRK11.05588367
47CDK81.05546127
48FGFR21.01407866
49PRKCG1.00275037
50LATS11.00245985
51PLK20.99588078
52OXSR10.99100126
53ERBB20.98435210
54YES10.95362608
55DDR20.90139953
56STK390.89674766
57EPHA30.86514933
58NTRK30.86447577
59CCNB10.85621125
60PKN10.84171491
61PRKCE0.82791591
62ROCK10.82123628
63CDK90.81456843
64DYRK1A0.79703641
65PLK40.78829785
66PAK20.77495634
67MAP2K40.75774491
68NUAK10.74875891
69BRD40.74488995
70STK38L0.73971257
71CDC70.73516989
72PAK30.72029549
73RPS6KA20.71818485
74RPS6KB20.69173696
75MARK20.68526210
76PHKG20.67027375
77PHKG10.67027375
78DAPK20.66436299
79PDGFRB0.65903219
80AKT30.65516029
81CDK30.64687249
82SGK20.62521099
83WEE10.62509898
84RPS6KA40.61625763
85LATS20.61583524
86TSSK60.61569626
87PAK40.60651533
88SIK30.59689455
89IRAK20.59433928
90BCR0.58704863
91VRK20.58659923
92GSK3A0.58537606
93CDK70.58175573
94CAMK2A0.55320624
95PRKCZ0.54012674
96MAPK90.53074714
97TAF10.51710751
98SGK2230.51150644
99SGK4940.51150644
100HIPK20.50426824
101CDK60.50088861
102CAMK2B0.49843053
103ROCK20.48663486
104ADRBK10.48475169
105MAPK40.47355257
106FES0.47143226
107CLK10.46527182
108LMTK20.46437925
109EIF2AK20.45876670
110WNK40.45127294
111MAP2K20.44612521
112CDK140.44308348
113LRRK20.43480796
114CSNK1A10.40295502
115RPS6KA10.38852886
116MAPK80.38783730
117PRKACA0.38163658
118MAP2K70.37962998
119CDK10.37726895
120STK110.37582854
121BRSK20.37548329
122PRKG10.37136528
123CDK50.36318687
124NLK0.36147664
125CAMK40.36145151
126NME10.36063844
127CDK180.36046430
128CDK150.35943782
129CDK11A0.35764033
130PLK10.35017828
131TESK10.35014397
132MTOR0.34883992
133ATM0.34827379
134AKT10.34718607
135PRKAA10.34232131
136FGFR10.33968630
137PASK0.33434975
138PLK30.33220065
139CSNK1D0.33042168
140FER0.32896302
141CHUK0.32537078
142MAPK150.32433496
143MAP3K40.31654761
144GSK3B0.30921183
145CSNK1E0.30605117
146EIF2AK30.30061504
147RPS6KA50.28747139
148* CDK20.28608024
149PRKDC0.28455957
150CHEK20.28055866
151PNCK0.28036326
152ATR0.27893829
153IRAK10.27500538

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78815847
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.87244972
3Axon guidance_Homo sapiens_hsa043602.67017946
4Basal cell carcinoma_Homo sapiens_hsa052172.47347775
5Phototransduction_Homo sapiens_hsa047442.44191728
6Protein export_Homo sapiens_hsa030602.21806320
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21561544
8Colorectal cancer_Homo sapiens_hsa052102.14561260
9Endometrial cancer_Homo sapiens_hsa052132.10607833
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08918165
11Butanoate metabolism_Homo sapiens_hsa006502.01575644
12Oxidative phosphorylation_Homo sapiens_hsa001902.01450095
13Hedgehog signaling pathway_Homo sapiens_hsa043401.98172331
14Spliceosome_Homo sapiens_hsa030401.96024927
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88943160
16Notch signaling pathway_Homo sapiens_hsa043301.85745437
17Hippo signaling pathway_Homo sapiens_hsa043901.85078761
18Ribosome_Homo sapiens_hsa030101.84450257
19Non-homologous end-joining_Homo sapiens_hsa034501.83390329
20GABAergic synapse_Homo sapiens_hsa047271.83343539
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82725533
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.80416178
23Parkinsons disease_Homo sapiens_hsa050121.75229435
24Chronic myeloid leukemia_Homo sapiens_hsa052201.70772308
25Wnt signaling pathway_Homo sapiens_hsa043101.69456560
26* MicroRNAs in cancer_Homo sapiens_hsa052061.64717697
27Taste transduction_Homo sapiens_hsa047421.63242919
28mRNA surveillance pathway_Homo sapiens_hsa030151.62531109
29Propanoate metabolism_Homo sapiens_hsa006401.62370392
30Viral myocarditis_Homo sapiens_hsa054161.57763884
31Morphine addiction_Homo sapiens_hsa050321.56200984
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53522789
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.52330099
34Steroid biosynthesis_Homo sapiens_hsa001001.50775682
35RNA polymerase_Homo sapiens_hsa030201.50653023
36Linoleic acid metabolism_Homo sapiens_hsa005911.48579360
37Circadian entrainment_Homo sapiens_hsa047131.39810357
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36232708
39Adherens junction_Homo sapiens_hsa045201.35101305
40Small cell lung cancer_Homo sapiens_hsa052221.34118932
41Renal cell carcinoma_Homo sapiens_hsa052111.33583928
42Glioma_Homo sapiens_hsa052141.32379751
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31500569
44Ether lipid metabolism_Homo sapiens_hsa005651.29624729
45TGF-beta signaling pathway_Homo sapiens_hsa043501.29096878
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.25453607
47RNA degradation_Homo sapiens_hsa030181.25345832
48Pancreatic cancer_Homo sapiens_hsa052121.24605870
49Focal adhesion_Homo sapiens_hsa045101.22260277
50ErbB signaling pathway_Homo sapiens_hsa040121.21815640
51Non-small cell lung cancer_Homo sapiens_hsa052231.21794715
52Huntingtons disease_Homo sapiens_hsa050161.21676958
53Prostate cancer_Homo sapiens_hsa052151.21602218
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19361763
55Melanogenesis_Homo sapiens_hsa049161.18357305
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18164935
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17913150
58Cell cycle_Homo sapiens_hsa041101.17568047
59Cardiac muscle contraction_Homo sapiens_hsa042601.17539443
60Nitrogen metabolism_Homo sapiens_hsa009101.16688568
61Alcoholism_Homo sapiens_hsa050341.16383284
62Tryptophan metabolism_Homo sapiens_hsa003801.16094187
63Amphetamine addiction_Homo sapiens_hsa050311.15044903
64Pathways in cancer_Homo sapiens_hsa052001.15005959
65Melanoma_Homo sapiens_hsa052181.13566522
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12641631
67Gap junction_Homo sapiens_hsa045401.11190205
68Caffeine metabolism_Homo sapiens_hsa002321.10642649
69Alzheimers disease_Homo sapiens_hsa050101.10542590
70Proteoglycans in cancer_Homo sapiens_hsa052051.10525875
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08694891
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05380709
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04883470
74Olfactory transduction_Homo sapiens_hsa047401.04233444
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03805060
76ECM-receptor interaction_Homo sapiens_hsa045121.02314525
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02295157
78Homologous recombination_Homo sapiens_hsa034401.01545750
79Selenocompound metabolism_Homo sapiens_hsa004500.98569205
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98135457
81Tight junction_Homo sapiens_hsa045300.97108995
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94190289
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.93482519
84Collecting duct acid secretion_Homo sapiens_hsa049660.93233605
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91769633
86HTLV-I infection_Homo sapiens_hsa051660.90417197
87Systemic lupus erythematosus_Homo sapiens_hsa053220.90344537
88Acute myeloid leukemia_Homo sapiens_hsa052210.89811844
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88315790
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86763612
91Bladder cancer_Homo sapiens_hsa052190.86558018
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.85673734
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.84410024
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84370295
95FoxO signaling pathway_Homo sapiens_hsa040680.84139479
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83650652
97Cholinergic synapse_Homo sapiens_hsa047250.83646899
98Chemical carcinogenesis_Homo sapiens_hsa052040.82338676
99Prolactin signaling pathway_Homo sapiens_hsa049170.82297864
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81285581
101Circadian rhythm_Homo sapiens_hsa047100.81222578
102Rap1 signaling pathway_Homo sapiens_hsa040150.79493117
103Estrogen signaling pathway_Homo sapiens_hsa049150.79296118
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79109801
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79069856
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78556900
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78255529
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78168334
109p53 signaling pathway_Homo sapiens_hsa041150.77463572
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76673660
111Retinol metabolism_Homo sapiens_hsa008300.76412936
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76145726
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76049858
114Viral carcinogenesis_Homo sapiens_hsa052030.75801426
115beta-Alanine metabolism_Homo sapiens_hsa004100.75621454
116Cocaine addiction_Homo sapiens_hsa050300.75087597
117VEGF signaling pathway_Homo sapiens_hsa043700.73897882
118Synaptic vesicle cycle_Homo sapiens_hsa047210.72868548
119Ras signaling pathway_Homo sapiens_hsa040140.72621253
120Regulation of autophagy_Homo sapiens_hsa041400.72584005
121Thyroid cancer_Homo sapiens_hsa052160.71200272
122Dopaminergic synapse_Homo sapiens_hsa047280.70475740
123RNA transport_Homo sapiens_hsa030130.69982339
124ABC transporters_Homo sapiens_hsa020100.69750940
125Insulin secretion_Homo sapiens_hsa049110.69664848
126B cell receptor signaling pathway_Homo sapiens_hsa046620.66960897
127Nucleotide excision repair_Homo sapiens_hsa034200.66835442
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66546372
129Hepatitis B_Homo sapiens_hsa051610.66505568
130Proteasome_Homo sapiens_hsa030500.66316160
131T cell receptor signaling pathway_Homo sapiens_hsa046600.65450326
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.64905126
133Oocyte meiosis_Homo sapiens_hsa041140.64861362
134Long-term depression_Homo sapiens_hsa047300.64759223
135Choline metabolism in cancer_Homo sapiens_hsa052310.64211721
136Lysine degradation_Homo sapiens_hsa003100.62902513
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61948179
138Dilated cardiomyopathy_Homo sapiens_hsa054140.61355700
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61103057
140Platelet activation_Homo sapiens_hsa046110.60940854
141MAPK signaling pathway_Homo sapiens_hsa040100.60647831
142Fanconi anemia pathway_Homo sapiens_hsa034600.59949422
143mTOR signaling pathway_Homo sapiens_hsa041500.59660422
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.58760457
145Peroxisome_Homo sapiens_hsa041460.58583531
146Glutamatergic synapse_Homo sapiens_hsa047240.58361458
147Basal transcription factors_Homo sapiens_hsa030220.57737236
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57621807
149Epstein-Barr virus infection_Homo sapiens_hsa051690.56667211
150GnRH signaling pathway_Homo sapiens_hsa049120.56191211
151Fatty acid elongation_Homo sapiens_hsa000620.55477665
152Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55424345
153Amoebiasis_Homo sapiens_hsa051460.54814784
154Calcium signaling pathway_Homo sapiens_hsa040200.54094025
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52312355
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51405680
157Base excision repair_Homo sapiens_hsa034100.51404256
158N-Glycan biosynthesis_Homo sapiens_hsa005100.51267258
159Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51214989
160AMPK signaling pathway_Homo sapiens_hsa041520.50957201
161Serotonergic synapse_Homo sapiens_hsa047260.50882920
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50490182
163Salivary secretion_Homo sapiens_hsa049700.50131749
164Mismatch repair_Homo sapiens_hsa034300.50104710
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49723670
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48141068
167Fat digestion and absorption_Homo sapiens_hsa049750.46860404
168cAMP signaling pathway_Homo sapiens_hsa040240.45124492
169Ovarian steroidogenesis_Homo sapiens_hsa049130.44591250
170Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44490061
171Purine metabolism_Homo sapiens_hsa002300.44123415
172Dorso-ventral axis formation_Homo sapiens_hsa043200.40592362

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