SOX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.34256987
2postsynaptic membrane organization (GO:0001941)5.26168742
3presynaptic membrane organization (GO:0097090)4.65156501
4protoporphyrinogen IX metabolic process (GO:0046501)4.33004043
5negative regulation of cytosolic calcium ion concentration (GO:0051481)4.32365751
6nucleobase catabolic process (GO:0046113)4.18517780
7protoporphyrinogen IX biosynthetic process (GO:0006782)3.72219810
8response to methylmercury (GO:0051597)3.69839092
9gamma-aminobutyric acid transport (GO:0015812)3.64531969
10negative regulation of oligodendrocyte differentiation (GO:0048715)3.60407952
11somite development (GO:0061053)3.56642226
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51232492
13nonmotile primary cilium assembly (GO:0035058)3.30788338
14glycogen catabolic process (GO:0005980)3.28545182
15C4-dicarboxylate transport (GO:0015740)3.25102678
16cerebral cortex radially oriented cell migration (GO:0021799)3.22479500
17glucan catabolic process (GO:0009251)3.20888447
18chondroitin sulfate catabolic process (GO:0030207)3.18552270
19relaxation of smooth muscle (GO:0044557)3.17007758
20alpha-linolenic acid metabolic process (GO:0036109)3.16927271
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.14869997
22negative regulation of neurotransmitter transport (GO:0051589)3.12973728
23forebrain neuron differentiation (GO:0021879)3.10553874
24cell communication by electrical coupling (GO:0010644)3.09647778
25regulation of oligodendrocyte differentiation (GO:0048713)3.09300770
26positive regulation of oligodendrocyte differentiation (GO:0048714)3.08188498
27sodium ion export (GO:0071436)3.06951525
28regulation of skeletal muscle contraction (GO:0014819)3.06898170
29auditory behavior (GO:0031223)3.05949491
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05097166
31protein polyglutamylation (GO:0018095)3.03421204
32locomotory exploration behavior (GO:0035641)3.01617882
33retinal rod cell development (GO:0046548)3.01284941
34vocalization behavior (GO:0071625)3.00654087
35neuron cell-cell adhesion (GO:0007158)3.00621999
36epithelial cilium movement (GO:0003351)2.97629174
37behavioral response to nicotine (GO:0035095)2.96369763
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95625442
39dermatan sulfate metabolic process (GO:0030205)2.94922342
40very-low-density lipoprotein particle assembly (GO:0034379)2.94166928
41synapse assembly (GO:0007416)2.93655125
42olfactory bulb development (GO:0021772)2.92837693
43axonal fasciculation (GO:0007413)2.92037706
44ionotropic glutamate receptor signaling pathway (GO:0035235)2.92033708
45dendrite morphogenesis (GO:0048813)2.92029789
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91637153
47mechanosensory behavior (GO:0007638)2.91532903
48dermatan sulfate biosynthetic process (GO:0030208)2.91496508
49limb development (GO:0060173)2.90785100
50appendage development (GO:0048736)2.90785100
51amino acid import (GO:0043090)2.90611197
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90137969
53positive regulation of fatty acid oxidation (GO:0046321)2.89868588
54cellular polysaccharide catabolic process (GO:0044247)2.89471350
55hemoglobin metabolic process (GO:0020027)2.89147176
56carnitine transmembrane transport (GO:1902603)2.87822456
57startle response (GO:0001964)2.87319847
58alanine transport (GO:0032328)2.86668662
59embryonic retina morphogenesis in camera-type eye (GO:0060059)2.86575062
60inner ear receptor stereocilium organization (GO:0060122)2.85370444
61carnitine shuttle (GO:0006853)2.84286104
62fucose catabolic process (GO:0019317)2.83888396
63L-fucose metabolic process (GO:0042354)2.83888396
64L-fucose catabolic process (GO:0042355)2.83888396
65response to pheromone (GO:0019236)2.83861114
66innervation (GO:0060384)2.83183162
67neuronal action potential propagation (GO:0019227)2.82086072
68amino-acid betaine transport (GO:0015838)2.81032573
69carnitine transport (GO:0015879)2.81032573
70intraciliary transport (GO:0042073)2.79339928
71regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78496456
72pyrimidine nucleobase catabolic process (GO:0006208)2.78260881
73ketone body metabolic process (GO:1902224)2.77717787
74lysine catabolic process (GO:0006554)2.75949098
75lysine metabolic process (GO:0006553)2.75949098
76neuronal stem cell maintenance (GO:0097150)2.75897020
77polysaccharide catabolic process (GO:0000272)2.75213456
78striatum development (GO:0021756)2.75058775
79neuron fate determination (GO:0048664)2.74302708
80prepulse inhibition (GO:0060134)2.73984387
81glutamate receptor signaling pathway (GO:0007215)2.72993486
82retinal ganglion cell axon guidance (GO:0031290)2.72677880
83cilium morphogenesis (GO:0060271)2.71025801
84reflex (GO:0060004)2.70903754
85aspartate family amino acid catabolic process (GO:0009068)2.70177985
86neuron recognition (GO:0008038)2.69858144
87detection of light stimulus involved in sensory perception (GO:0050962)2.69445748
88detection of light stimulus involved in visual perception (GO:0050908)2.69445748
89cilium organization (GO:0044782)2.67802098
90cellular ketone body metabolic process (GO:0046950)2.67712817
91glycosphingolipid biosynthetic process (GO:0006688)2.66828318
92eye photoreceptor cell differentiation (GO:0001754)2.65443482
93photoreceptor cell differentiation (GO:0046530)2.65443482
94actin-myosin filament sliding (GO:0033275)2.65054643
95muscle filament sliding (GO:0030049)2.65054643
96cardiac myofibril assembly (GO:0055003)2.63662537
97regulation of response to osmotic stress (GO:0047484)2.63480261
98glial cell proliferation (GO:0014009)2.63224011
99negative regulation of sodium ion transport (GO:0010766)2.61436588
100auditory receptor cell stereocilium organization (GO:0060088)2.61295555
101cilium assembly (GO:0042384)2.61224237
102acrosome reaction (GO:0007340)2.61151255
103regulation of cilium movement (GO:0003352)2.61091096
104L-amino acid import (GO:0043092)2.61015816
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.60909349
106transmission of nerve impulse (GO:0019226)2.60169561
107neural tube formation (GO:0001841)2.59866491
108porphyrin-containing compound biosynthetic process (GO:0006779)2.57316674
109regulation of neurotransmitter uptake (GO:0051580)2.57252245
110synaptic transmission, glutamatergic (GO:0035249)2.57215465
111protein localization to cilium (GO:0061512)2.56927542
112cilium movement (GO:0003341)2.56841648
113fatty acid transmembrane transport (GO:1902001)2.56044196
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55777717
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55590189
116cellular sodium ion homeostasis (GO:0006883)2.54097851
117spinal cord motor neuron differentiation (GO:0021522)2.51489082
118positive regulation of mitochondrial fission (GO:0090141)2.49172083
119axoneme assembly (GO:0035082)2.49114979
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48761958
121positive regulation of synapse assembly (GO:0051965)2.48615334
122regulation of fatty acid beta-oxidation (GO:0031998)2.48475029
123endocardial cushion morphogenesis (GO:0003203)2.48407625
124regulation of respiratory system process (GO:0044065)2.46566774
125lactate metabolic process (GO:0006089)2.46287174
126dicarboxylic acid biosynthetic process (GO:0043650)2.45258246
127cilium or flagellum-dependent cell motility (GO:0001539)2.45214558
128regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45071551
129positive regulation of glycogen biosynthetic process (GO:0045725)2.43747768
130short-chain fatty acid metabolic process (GO:0046459)2.42586627
131cerebral cortex cell migration (GO:0021795)2.42392429
132calcium ion import (GO:0070509)2.41994548
133photoreceptor cell maintenance (GO:0045494)2.41837394
134platelet dense granule organization (GO:0060155)2.41339067
135protein localization to synapse (GO:0035418)2.41112664
136protein-cofactor linkage (GO:0018065)2.40883683
137myofibril assembly (GO:0030239)2.39961669
138atrial cardiac muscle cell action potential (GO:0086014)2.39096348
139carnitine metabolic process (GO:0009437)2.39061411
140negative regulation of astrocyte differentiation (GO:0048712)2.37946970
141tetrapyrrole biosynthetic process (GO:0033014)2.37761997
142dendritic spine morphogenesis (GO:0060997)2.37365020
143neurotransmitter-gated ion channel clustering (GO:0072578)2.37036599
144centriole replication (GO:0007099)2.36909479
145positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.36821085
146regulation of sarcomere organization (GO:0060297)2.36399926
147regulation of membrane repolarization (GO:0060306)2.36161350
148sympathetic nervous system development (GO:0048485)2.36014733
149limb bud formation (GO:0060174)2.35060696
150tricarboxylic acid cycle (GO:0006099)2.34986425
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.34756010
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34595714
153dicarboxylic acid catabolic process (GO:0043649)2.34553371
154melanin biosynthetic process (GO:0042438)2.34324842
155regulation of bile acid biosynthetic process (GO:0070857)2.33878456
156central nervous system myelination (GO:0022010)2.33298511
157axon ensheathment in central nervous system (GO:0032291)2.33298511
158cellular component assembly involved in morphogenesis (GO:0010927)2.33284518
159negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32777785
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32772239
161spinal cord development (GO:0021510)2.32736419
162lateral sprouting from an epithelium (GO:0060601)2.31615422
163proline transport (GO:0015824)2.31561801
164neuronal action potential (GO:0019228)2.31473933
165motile cilium assembly (GO:0044458)2.31028507
166positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30920637
167regulation of development, heterochronic (GO:0040034)2.30910357
168amino-acid betaine metabolic process (GO:0006577)2.30900254
169oligodendrocyte differentiation (GO:0048709)2.30775816
170cellular potassium ion homeostasis (GO:0030007)2.30249833
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.29346497
172regulation of fatty acid oxidation (GO:0046320)2.29309380
173regulation of synapse structural plasticity (GO:0051823)2.28590930
174positive regulation of glycogen metabolic process (GO:0070875)2.27583739
175fructose metabolic process (GO:0006000)2.26679044
176substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.26661625
177substrate-independent telencephalic tangential migration (GO:0021826)2.26661625
178chondroitin sulfate biosynthetic process (GO:0030206)2.26495549
179cardiac muscle contraction (GO:0060048)2.25379491
180succinate metabolic process (GO:0006105)2.25132499
181positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.25104328
182glycolytic process (GO:0006096)2.24702112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21572438_ChIP-Seq_LNCaP_Human3.27443350
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11155645
3GBX2_23144817_ChIP-Seq_PC3_Human2.80650739
4EZH2_22144423_ChIP-Seq_EOC_Human2.77423548
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25970157
6RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.12787966
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12221115
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10068285
9VDR_22108803_ChIP-Seq_LS180_Human2.08079937
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.06979817
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06757982
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02789107
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.01985106
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96335544
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95998509
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88973957
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88973957
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88813119
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.83057506
20* EZH2_27294783_Chip-Seq_ESCs_Mouse1.79642541
21* CBX2_27304074_Chip-Seq_ESCs_Mouse1.79051726
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.77934224
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77429369
24DROSHA_22980978_ChIP-Seq_HELA_Human1.75367111
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73434874
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73382065
27ER_23166858_ChIP-Seq_MCF-7_Human1.69987481
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68793691
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68508892
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67865807
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67458660
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64738234
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.64017511
34EWS_26573619_Chip-Seq_HEK293_Human1.62459735
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61005387
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.60681223
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59726465
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59241490
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52935337
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49846196
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49312390
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45934884
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45059586
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43991886
45ZNF274_21170338_ChIP-Seq_K562_Hela1.43532382
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43361927
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42245402
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41994327
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.41378143
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.41035749
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39581331
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38953105
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38709938
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.38661546
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.37349982
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.36447554
57REST_21632747_ChIP-Seq_MESCs_Mouse1.34421915
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.34019623
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32898058
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29723032
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29723032
62* RUNX2_22187159_ChIP-Seq_PCA_Human1.29548343
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28792584
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27475613
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27250074
66* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26077208
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25162367
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24311149
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.24145503
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24130326
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22505497
72* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21390918
73* AR_25329375_ChIP-Seq_VCAP_Human1.20467680
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.20038631
75P300_19829295_ChIP-Seq_ESCs_Human1.19259772
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19118006
77TAF15_26573619_Chip-Seq_HEK293_Human1.19066037
78P53_22387025_ChIP-Seq_ESCs_Mouse1.18601352
79* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18194048
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17534789
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.17494695
82FUS_26573619_Chip-Seq_HEK293_Human1.17412318
83* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16930492
84BCAT_22108803_ChIP-Seq_LS180_Human1.16488301
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16139782
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15843606
87CBP_20019798_ChIP-Seq_JUKART_Human1.15843606
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13981337
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13871536
90* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13473492
91* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13127387
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12264704
93TCF4_22108803_ChIP-Seq_LS180_Human1.11222546
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.10245950
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.10222322
96IRF1_19129219_ChIP-ChIP_H3396_Human1.10105172
97IGF1R_20145208_ChIP-Seq_DFB_Human1.09519046
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09383982
99KDM2B_26808549_Chip-Seq_REH_Human1.08858147
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08801458
101* AR_19668381_ChIP-Seq_PC3_Human1.08614153
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.08570024
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08087236
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07919884
105* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06628379
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.06418297
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05682318
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05666206
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05596537
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05283898
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05242824
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05203738
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04729430
114STAT3_23295773_ChIP-Seq_U87_Human1.04518490
115SOX2_19829295_ChIP-Seq_ESCs_Human1.04374715
116NANOG_19829295_ChIP-Seq_ESCs_Human1.04374715
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03903614
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03365385
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.03200568
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02832559
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02744329
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.02713207
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00392740
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00355137
125WDR5_24793694_ChIP-Seq_LNCAP_Human1.00204616
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.00200178
127* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00150279
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99267772
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98631237
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98050271
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97867901
132* ISL1_27105846_Chip-Seq_CPCs_Mouse0.96336784
133* TCF4_23295773_ChIP-Seq_U87_Human0.96262680
134SOX9_26525672_Chip-Seq_HEART_Mouse0.95996757
135* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95511678
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.95491942
137* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92525099
138* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92445162
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92134458
140* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91814794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.76689061
2MP0002139_abnormal_hepatobiliary_system3.15372720
3MP0004145_abnormal_muscle_electrophysio2.94188358
4MP0004233_abnormal_muscle_weight2.42073897
5MP0000751_myopathy2.41503720
6MP0005360_urolithiasis2.25578860
7MP0005670_abnormal_white_adipose2.22593321
8MP0002102_abnormal_ear_morphology2.19669863
9MP0003880_abnormal_central_pattern2.19619933
10MP0005248_abnormal_Harderian_gland2.13378769
11MP0004270_analgesia2.12105051
12MP0003011_delayed_dark_adaptation2.11207137
13MP0005551_abnormal_eye_electrophysiolog2.09905654
14MP0003656_abnormal_erythrocyte_physiolo2.05040862
15MP0008775_abnormal_heart_ventricle2.00963026
16MP0003136_yellow_coat_color1.99544060
17MP0001529_abnormal_vocalization1.99270345
18MP0000749_muscle_degeneration1.95882571
19MP0004130_abnormal_muscle_cell1.95079999
20MP0004142_abnormal_muscle_tone1.92470129
21MP0004215_abnormal_myocardial_fiber1.91972386
22MP0002090_abnormal_vision1.91878373
23MP0002736_abnormal_nociception_after1.91640448
24MP0004036_abnormal_muscle_relaxation1.88866439
25MP0004858_abnormal_nervous_system1.84979580
26MP0004084_abnormal_cardiac_muscle1.83303919
27MP0009384_cardiac_valve_regurgitation1.82340474
28MP0003787_abnormal_imprinting1.81486282
29MP0000566_synostosis1.81266404
30MP0004134_abnormal_chest_morphology1.75101285
31MP0005645_abnormal_hypothalamus_physiol1.74985510
32MP0005646_abnormal_pituitary_gland1.73475946
33MP0001968_abnormal_touch/_nociception1.73448103
34MP0008789_abnormal_olfactory_epithelium1.72053262
35MP0002272_abnormal_nervous_system1.71314609
36MP0002282_abnormal_trachea_morphology1.70183859
37MP0004147_increased_porphyrin_level1.67747870
38MP0005620_abnormal_muscle_contractility1.65009538
39MP0009250_abnormal_appendicular_skeleto1.63848188
40MP0002095_abnormal_skin_pigmentation1.63678546
41MP0006276_abnormal_autonomic_nervous1.59665666
42MP0001984_abnormal_olfaction1.57629503
43MP0005171_absent_coat_pigmentation1.56435570
44MP0005666_abnormal_adipose_tissue1.53534413
45MP0005499_abnormal_olfactory_system1.50095382
46MP0005394_taste/olfaction_phenotype1.50095382
47MP0002089_abnormal_postnatal_growth/wei1.46625924
48MP0002938_white_spotting1.45897610
49MP0002108_abnormal_muscle_morphology1.45547431
50MP0001485_abnormal_pinna_reflex1.45005635
51MP0005365_abnormal_bile_salt1.44446558
52MP0002638_abnormal_pupillary_reflex1.43271702
53MP0002837_dystrophic_cardiac_calcinosis1.41365611
54MP0009697_abnormal_copulation1.40132498
55MP0003121_genomic_imprinting1.39478021
56MP0006072_abnormal_retinal_apoptosis1.36345854
57MP0005187_abnormal_penis_morphology1.30414894
58MP0002572_abnormal_emotion/affect_behav1.29741759
59MP0004087_abnormal_muscle_fiber1.28440236
60MP0006292_abnormal_olfactory_placode1.27370258
61MP0002106_abnormal_muscle_physiology1.26783953
62MP0002249_abnormal_larynx_morphology1.26637904
63MP0010329_abnormal_lipoprotein_level1.25553550
64MP0008995_early_reproductive_senescence1.25332235
65MP0005085_abnormal_gallbladder_physiolo1.24513417
66MP0005410_abnormal_fertilization1.23230903
67MP0000026_abnormal_inner_ear1.22465718
68MP0002332_abnormal_exercise_endurance1.22104638
69MP0003195_calcinosis1.20616391
70MP0000778_abnormal_nervous_system1.20302203
71MP0005386_behavior/neurological_phenoty1.20110077
72MP0004924_abnormal_behavior1.20110077
73MP0009780_abnormal_chondrocyte_physiolo1.19651659
74MP0005174_abnormal_tail_pigmentation1.19633615
75MP0005369_muscle_phenotype1.18934593
76MP0002822_catalepsy1.18547355
77MP0004043_abnormal_pH_regulation1.18357092
78MP0000631_abnormal_neuroendocrine_gland1.18318998
79MP0005253_abnormal_eye_physiology1.17555854
80MP0000759_abnormal_skeletal_muscle1.16974951
81MP0003137_abnormal_impulse_conducting1.15197722
82MP0002751_abnormal_autonomic_nervous1.13358530
83MP0000015_abnormal_ear_pigmentation1.13340494
84MP0004133_heterotaxia1.12341631
85MP0002269_muscular_atrophy1.11801357
86MP0004742_abnormal_vestibular_system1.11443469
87MP0000427_abnormal_hair_cycle1.08465220
88MP0002972_abnormal_cardiac_muscle1.08334413
89MP0002733_abnormal_thermal_nociception1.06632647
90MP0001970_abnormal_pain_threshold1.05635706
91MP0000049_abnormal_middle_ear1.03380994
92MP0008877_abnormal_DNA_methylation1.02578373
93MP0001963_abnormal_hearing_physiology1.02360497
94MP0001299_abnormal_eye_distance/1.02344817
95MP0005423_abnormal_somatic_nervous1.00684923
96MP0002735_abnormal_chemical_nociception1.00594108
97MP0000372_irregular_coat_pigmentation1.00219109
98MP0002653_abnormal_ependyma_morphology0.99377620
99MP0001270_distended_abdomen0.99225859
100MP0001502_abnormal_circadian_rhythm0.98075638
101MP0003755_abnormal_palate_morphology0.97332114
102MP0002882_abnormal_neuron_morphology0.96891384
103MP0002876_abnormal_thyroid_physiology0.95428436
104MP0001486_abnormal_startle_reflex0.94815905
105MP0000747_muscle_weakness0.94709190
106MP0001986_abnormal_taste_sensitivity0.93285898
107MP0002752_abnormal_somatic_nervous0.92384996
108MP0005195_abnormal_posterior_eye0.92081679
109MP0003938_abnormal_ear_development0.91920133
110MP0003950_abnormal_plasma_membrane0.91662026
111MP0004885_abnormal_endolymph0.90480445
112MP0003937_abnormal_limbs/digits/tail_de0.88874841
113MP0003252_abnormal_bile_duct0.88011007
114MP0001346_abnormal_lacrimal_gland0.86712301
115MP0001501_abnormal_sleep_pattern0.85246825
116MP0003385_abnormal_body_wall0.84844689
117MP0002229_neurodegeneration0.84405209
118MP0000428_abnormal_craniofacial_morphol0.84396700
119MP0002152_abnormal_brain_morphology0.84127679
120MP0000163_abnormal_cartilage_morphology0.83693974
121MP0002067_abnormal_sensory_capabilities0.83143069
122MP0001666_abnormal_nutrient_absorption0.83065681
123MP0002971_abnormal_brown_adipose0.83019245
124MP0005408_hypopigmentation0.82531708
125MP0002233_abnormal_nose_morphology0.82081260
126MP0002557_abnormal_social/conspecific_i0.81219156
127MP0003635_abnormal_synaptic_transmissio0.81047043
128MP0004859_abnormal_synaptic_plasticity0.79797980
129MP0005391_vision/eye_phenotype0.79372963
130MP0004085_abnormal_heartbeat0.79252203
131MP0000647_abnormal_sebaceous_gland0.78547321
132MP0003633_abnormal_nervous_system0.78464857
133MP0004484_altered_response_of0.78452515
134MP0003122_maternal_imprinting0.78420742
135MP0002066_abnormal_motor_capabilities/c0.77034107
136MP0004811_abnormal_neuron_physiology0.77000081
137MP0005330_cardiomyopathy0.76360202
138MP0005083_abnormal_biliary_tract0.76346924
139MP0000762_abnormal_tongue_morphology0.76092942
140MP0003115_abnormal_respiratory_system0.75900326
141MP0002234_abnormal_pharynx_morphology0.74674771
142MP0000955_abnormal_spinal_cord0.73844515
143MP0009046_muscle_twitch0.73671211
144MP0000569_abnormal_digit_pigmentation0.72880631
145MP0002063_abnormal_learning/memory/cond0.71838080
146MP0001324_abnormal_eye_pigmentation0.71178653
147MP0001177_atelectasis0.69938635
148MP0002064_seizures0.69153159
149MP0005257_abnormal_intraocular_pressure0.68511371
150MP0009745_abnormal_behavioral_response0.68359094
151MP0003941_abnormal_skin_development0.67991799
152MP0002734_abnormal_mechanical_nocicepti0.67475601
153MP0002118_abnormal_lipid_homeostasis0.67257956
154MP0000750_abnormal_muscle_regeneration0.66467729
155MP0003329_amyloid_beta_deposits0.66041766
156MP0003698_abnormal_male_reproductive0.65942882
157MP0003634_abnormal_glial_cell0.65914828

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.39636045
2Congenital stationary night blindness (HP:0007642)4.55232711
3Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.19873796
4Exercise-induced muscle cramps (HP:0003710)4.14589110
5Myoglobinuria (HP:0002913)3.90429196
6Poikilocytosis (HP:0004447)3.85884029
7True hermaphroditism (HP:0010459)3.73832081
8Pancreatic cysts (HP:0001737)3.42878454
9Epiphyseal dysplasia (HP:0002656)3.42170278
10Hypoplastic ischia (HP:0003175)3.35999557
11Pancreatic fibrosis (HP:0100732)3.27798045
12Acanthocytosis (HP:0001927)3.22505910
13Medial flaring of the eyebrow (HP:0010747)3.17225795
14Molar tooth sign on MRI (HP:0002419)3.09634472
15Abnormality of midbrain morphology (HP:0002418)3.09634472
16Nephronophthisis (HP:0000090)2.97790432
17Cholelithiasis (HP:0001081)2.96138751
18Drooling (HP:0002307)2.95770373
19Muscle fiber inclusion bodies (HP:0100299)2.95173475
20Abnormality of the ischium (HP:0003174)2.91264298
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.82320230
22Gait imbalance (HP:0002141)2.80402740
23Chronic hepatic failure (HP:0100626)2.79341807
24Intestinal atresia (HP:0011100)2.76502699
25Cholecystitis (HP:0001082)2.74168000
26Abnormal gallbladder physiology (HP:0012438)2.74168000
27Muscle hypertrophy of the lower extremities (HP:0008968)2.69838426
28Difficulty running (HP:0009046)2.68544473
29Abnormality of the renal medulla (HP:0100957)2.68504573
30Abnormal gallbladder morphology (HP:0012437)2.66307521
31Calf muscle hypertrophy (HP:0008981)2.65626158
32Excessive salivation (HP:0003781)2.64981599
33Congenital primary aphakia (HP:0007707)2.62985604
34Type II lissencephaly (HP:0007260)2.62067149
35Hypochromic microcytic anemia (HP:0004840)2.61989995
36Cerebellar dysplasia (HP:0007033)2.60400220
37Absent speech (HP:0001344)2.59948608
38Abnormality of the pubic bones (HP:0003172)2.59864303
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.59168480
40Type 1 muscle fiber predominance (HP:0003803)2.57843058
41Abnormality of the calf musculature (HP:0001430)2.55263715
42Nemaline bodies (HP:0003798)2.52197521
43Nephrogenic diabetes insipidus (HP:0009806)2.51333586
44Abnormality of the labia minora (HP:0012880)2.49763124
45Rhabdomyolysis (HP:0003201)2.46330662
46Abnormal finger flexion creases (HP:0006143)2.41574271
47Central scotoma (HP:0000603)2.38080082
48Neonatal short-limb short stature (HP:0008921)2.35563656
49Hypoalphalipoproteinemia (HP:0003233)2.35215799
50Abnormality of the renal cortex (HP:0011035)2.34339676
51Aplasia involving bones of the extremities (HP:0009825)2.33351041
52Aplasia involving bones of the upper limbs (HP:0009823)2.33351041
53Aplasia of the phalanges of the hand (HP:0009802)2.33351041
54Reticulocytosis (HP:0001923)2.32521613
55Septo-optic dysplasia (HP:0100842)2.30820525
56Polyphagia (HP:0002591)2.28293600
57Oligodactyly (hands) (HP:0001180)2.26600571
58Scotoma (HP:0000575)2.26367769
59Retinal dysplasia (HP:0007973)2.26005217
60Genital tract atresia (HP:0001827)2.25307740
61Hyperglycinemia (HP:0002154)2.22906086
62Febrile seizures (HP:0002373)2.22416627
63Abnormal drinking behavior (HP:0030082)2.21626667
64Polydipsia (HP:0001959)2.21626667
65Progressive cerebellar ataxia (HP:0002073)2.21404536
66Lissencephaly (HP:0001339)2.21327390
67Megalencephaly (HP:0001355)2.21199998
68Cystic liver disease (HP:0006706)2.20310401
69Occipital encephalocele (HP:0002085)2.19589605
70Vitreoretinal degeneration (HP:0000655)2.18267901
71Rimmed vacuoles (HP:0003805)2.17709865
72Broad-based gait (HP:0002136)2.16972461
73Optic nerve hypoplasia (HP:0000609)2.16944607
74Postaxial hand polydactyly (HP:0001162)2.15810169
75Ketosis (HP:0001946)2.14628465
76Ketoacidosis (HP:0001993)2.14118569
77Absent phalangeal crease (HP:0006109)2.12577736
78Vaginal atresia (HP:0000148)2.12536139
79Long clavicles (HP:0000890)2.11588031
80Muscle stiffness (HP:0003552)2.11501162
81Postaxial foot polydactyly (HP:0001830)2.11281353
82Specific learning disability (HP:0001328)2.10671487
83Thyroid-stimulating hormone excess (HP:0002925)2.09292493
84Irregular epiphyses (HP:0010582)2.09217048
85Hyperglycinuria (HP:0003108)2.07823855
86Poor coordination (HP:0002370)2.07339461
87Tubular atrophy (HP:0000092)2.05746183
88Sclerocornea (HP:0000647)2.02954165
89Inability to walk (HP:0002540)2.02283942
90Keratoconus (HP:0000563)2.01384582
91Increased corneal curvature (HP:0100692)2.01384582
92Split foot (HP:0001839)2.00642093
93Pendular nystagmus (HP:0012043)1.99783144
94Round ear (HP:0100830)1.99756524
95Gastrointestinal atresia (HP:0002589)1.99167090
96Hyperventilation (HP:0002883)1.98711203
97Fibular hypoplasia (HP:0003038)1.98208106
98Hypoplasia of the fovea (HP:0007750)1.96789840
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.96789840
100Chorioretinal atrophy (HP:0000533)1.96028965
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.95670998
102Hypolipoproteinemia (HP:0010981)1.95606009
103Hyperbilirubinemia (HP:0002904)1.95420324
104Hepatoblastoma (HP:0002884)1.94730873
105Abolished electroretinogram (ERG) (HP:0000550)1.93383159
106Abnormality of the gallbladder (HP:0005264)1.92573620
107Blue irides (HP:0000635)1.91838043
108Large for gestational age (HP:0001520)1.91552626
109Muscle fiber splitting (HP:0003555)1.91503144
110Congenital hepatic fibrosis (HP:0002612)1.90960358
111Gaze-evoked nystagmus (HP:0000640)1.89137818
112Tubulointerstitial nephritis (HP:0001970)1.88447640
113Atonic seizures (HP:0010819)1.88224504
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.87883155
115Spastic tetraplegia (HP:0002510)1.87759222
116Bell-shaped thorax (HP:0001591)1.87597697
117Focal motor seizures (HP:0011153)1.87208677
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86999507
119Limited hip movement (HP:0008800)1.84810057
120Epidermoid cyst (HP:0200040)1.84377195
121Hemiparesis (HP:0001269)1.84193307
122Attenuation of retinal blood vessels (HP:0007843)1.83244561
123Narrow forehead (HP:0000341)1.81534943
124Microglossia (HP:0000171)1.81431449
125Abnormality of serine family amino acid metabolism (HP:0010894)1.80849027
126Abnormality of glycine metabolism (HP:0010895)1.80849027
127Anophthalmia (HP:0000528)1.79877560
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.79746510
129Hypsarrhythmia (HP:0002521)1.78950199
130Paralysis (HP:0003470)1.78400805
131Renal dysplasia (HP:0000110)1.77848305
132Oligodactyly (HP:0012165)1.76686863
133Anencephaly (HP:0002323)1.76384555
134Diaphragmatic weakness (HP:0009113)1.76261354
135Tubulointerstitial abnormality (HP:0001969)1.75960486
136Cupped ribs (HP:0000887)1.75138748
137Male pseudohermaphroditism (HP:0000037)1.74595034
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.73777757
139Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.73516715
140Epileptic encephalopathy (HP:0200134)1.73392177
141Congenital sensorineural hearing impairment (HP:0008527)1.71659431
142Epileptiform EEG discharges (HP:0011182)1.71377153
143EEG with generalized epileptiform discharges (HP:0011198)1.70561216
144Hip contracture (HP:0003273)1.69989828
145Abnormality of the middle phalanges of the toes (HP:0010183)1.69434902
146Absent/shortened dynein arms (HP:0200106)1.69419948
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.69419948
148Cortical dysplasia (HP:0002539)1.69356008
149Rib fusion (HP:0000902)1.69151469
150Subaortic stenosis (HP:0001682)1.69085300
151Abnormality of the left ventricular outflow tract (HP:0011103)1.69085300
152Pheochromocytoma (HP:0002666)1.68888208
153Neuroendocrine neoplasm (HP:0100634)1.68869679
154Short foot (HP:0001773)1.67829935
155Humeroradial synostosis (HP:0003041)1.67460782
156Synostosis involving the elbow (HP:0003938)1.67460782
157Maternal diabetes (HP:0009800)1.64549337
158Distal arthrogryposis (HP:0005684)1.63812863
159Osteomalacia (HP:0002749)1.63246084
160Abnormality of the 4th metacarpal (HP:0010012)1.63150111
161Myopathic facies (HP:0002058)1.62776967
162Hyporeflexia of lower limbs (HP:0002600)1.62028106
163EMG: myopathic abnormalities (HP:0003458)1.60293015
164Prolonged QT interval (HP:0001657)1.58515650
165Aplasia/Hypoplasia affecting the retina (HP:0008061)1.57981482
166Abnormality of the fovea (HP:0000493)1.57778122
167Calcaneovalgus deformity (HP:0001848)1.57178671
168Flat capital femoral epiphysis (HP:0003370)1.56771835
169Aplasia/Hypoplasia of the macula (HP:0008059)1.55871809
170Back pain (HP:0003418)1.55653735
171Insomnia (HP:0100785)1.55642092
172Pachygyria (HP:0001302)1.55186223
173Ulnar deviation of the wrist (HP:0003049)1.54683640
174Intrahepatic cholestasis (HP:0001406)1.54423677
175Sudden death (HP:0001699)1.53341092
176Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.52833540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.05547377
2PHKG24.05547377
3FRK4.01683749
4OBSCN3.25454331
5MAP4K22.67346926
6TNIK2.65520253
7SIK12.53733756
8MARK12.34638857
9PNCK2.26993601
10CASK2.21203402
11PDK42.08922501
12PDK32.08922501
13MUSK2.06636882
14TYRO32.04606998
15LMTK22.02031456
16PRKD31.93570419
17ICK1.91760985
18NTRK21.89772646
19PLK21.67042641
20BMPR1B1.63794811
21TRIB31.59871389
22MAP3K41.59056755
23BCR1.57351957
24DDR21.56473797
25MAPK131.55641928
26SGK21.54733171
27CAMK1D1.48691047
28CAMK1G1.46940267
29NME11.45529839
30TRIM281.45260576
31PIK3CA1.43902186
32SGK4941.43479050
33SGK2231.43479050
34BCKDK1.40356070
35NTRK31.39764926
36INSRR1.39378861
37NEK11.34883183
38PRKAA11.31545937
39SGK31.25240039
40TTN1.25164361
41PRKAA21.23974475
42CSNK1G21.22283492
43ACVR1B1.20060578
44CSNK1G11.17097674
45ERBB21.16159965
46EPHA41.15401334
47NUAK11.14984677
48ADRBK21.13811928
49MST1R1.11353568
50ERBB41.09017958
51CSNK1G31.06587188
52MAP3K71.05248612
53GRK11.05025730
54WEE11.04702472
55MAP2K41.04373207
56CSNK1A1L1.03294586
57MAPK151.03076914
58PDK21.01461042
59LATS11.01257151
60ROCK11.00757793
61MAP2K71.00335876
62TAOK20.97100586
63EPHB20.95586995
64DMPK0.95375994
65EPHA30.93685296
66UHMK10.91261650
67DYRK1A0.90817928
68CCNB10.90173585
69PINK10.89550146
70ZAK0.87540646
71PTK2B0.86154453
72WNK40.82850550
73FES0.82321882
74AKT30.80478543
75IRAK20.79661525
76STK380.78373423
77DAPK20.77044343
78PDGFRA0.76802289
79CDK190.76687286
80STK38L0.74825396
81PLK40.74446101
82PTK60.74301066
83BRSK20.73984017
84CAMK2A0.72654987
85DYRK30.70352203
86OXSR10.70263668
87MAPK110.69669490
88STK390.68113200
89SGK10.67774854
90CDK30.67113656
91CAMK40.67089616
92FGFR30.65615640
93FGFR20.65383281
94KSR10.64481764
95FGFR10.64013694
96MAPK120.62987525
97DYRK1B0.62334563
98WNK30.62272108
99STK240.61036490
100IRAK10.59223605
101PIK3CG0.58801188
102CDK80.58466544
103RPS6KA30.58445085
104STK110.58334192
105PDGFRB0.57975652
106PAK60.57644734
107ERBB30.56246625
108CAMK2B0.56190293
109EEF2K0.55925979
110AKT20.55099477
111TAOK10.54560723
112PKN10.53574002
113PAK30.53164334
114TAOK30.51230383
115PRKCG0.50609086
116RIPK10.49474015
117CAMKK20.49313604
118RET0.49249054
119CDC42BPA0.48950281
120CSNK1D0.48932270
121CSNK1A10.47779680
122PRKACG0.47580903
123BMX0.47207971
124VRK10.47080675
125MKNK10.46980243
126PLK30.46946736
127TIE10.46326022
128PRKG10.45964012
129MKNK20.45649703
130PRKCZ0.45275050
131PRKACB0.45213476
132CAMK10.44530860
133ROCK20.43021625
134DYRK20.41774596
135PRKACA0.41577327
136CAMK2D0.41068681
137PRKCH0.40451389
138CDK50.39340704
139PRKCE0.38790806
140GSK3A0.38375426
141NLK0.36583072
142YES10.35436508
143WNK10.34766732
144RPS6KA50.34212477
145ADRBK10.33614438
146RPS6KA40.33563680
147RPS6KB10.32689909
148EIF2AK10.32629698

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.41165369
2Propanoate metabolism_Homo sapiens_hsa006402.88865817
3Fatty acid metabolism_Homo sapiens_hsa012122.50315488
4Fatty acid degradation_Homo sapiens_hsa000712.40068362
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31103273
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.19994090
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18218493
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04608926
9Butanoate metabolism_Homo sapiens_hsa006502.04342984
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03791366
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98537983
12Fatty acid biosynthesis_Homo sapiens_hsa000611.97811694
13Vitamin B6 metabolism_Homo sapiens_hsa007501.97280597
14PPAR signaling pathway_Homo sapiens_hsa033201.89181545
15Linoleic acid metabolism_Homo sapiens_hsa005911.87472306
16Phototransduction_Homo sapiens_hsa047441.86909721
17Pyruvate metabolism_Homo sapiens_hsa006201.70905083
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70499914
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.69680306
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66952038
21Carbon metabolism_Homo sapiens_hsa012001.66107900
22Arginine biosynthesis_Homo sapiens_hsa002201.65349098
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.58750556
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57253090
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56836194
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56515182
27Caffeine metabolism_Homo sapiens_hsa002321.47547902
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42162505
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40254187
30Biosynthesis of amino acids_Homo sapiens_hsa012301.38790570
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38788841
32Taste transduction_Homo sapiens_hsa047421.37975760
33Cardiac muscle contraction_Homo sapiens_hsa042601.37923985
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37740263
35Circadian rhythm_Homo sapiens_hsa047101.36889321
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36342610
37Protein export_Homo sapiens_hsa030601.31704779
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31105610
39Amphetamine addiction_Homo sapiens_hsa050311.28386459
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27023969
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24498810
42Ether lipid metabolism_Homo sapiens_hsa005651.24206087
43Dilated cardiomyopathy_Homo sapiens_hsa054141.22601725
44Fatty acid elongation_Homo sapiens_hsa000621.20359509
45Starch and sucrose metabolism_Homo sapiens_hsa005001.19309072
46Dopaminergic synapse_Homo sapiens_hsa047281.18840352
47Glucagon signaling pathway_Homo sapiens_hsa049221.17933922
48Tryptophan metabolism_Homo sapiens_hsa003801.16428741
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15217232
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14933561
51GABAergic synapse_Homo sapiens_hsa047271.14788613
52Bile secretion_Homo sapiens_hsa049761.13737666
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10583326
54Lysine degradation_Homo sapiens_hsa003101.10557088
55Peroxisome_Homo sapiens_hsa041461.06847166
56Cocaine addiction_Homo sapiens_hsa050301.05851333
57AMPK signaling pathway_Homo sapiens_hsa041521.03208743
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03037773
59Nicotine addiction_Homo sapiens_hsa050331.02752413
60Chemical carcinogenesis_Homo sapiens_hsa052041.02632334
61Fructose and mannose metabolism_Homo sapiens_hsa000511.02630451
62beta-Alanine metabolism_Homo sapiens_hsa004101.00177650
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.00010290
64Long-term depression_Homo sapiens_hsa047300.99565192
65Oxidative phosphorylation_Homo sapiens_hsa001900.98512395
66Regulation of autophagy_Homo sapiens_hsa041400.95371215
67Protein digestion and absorption_Homo sapiens_hsa049740.93429680
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.92801399
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92217886
70Collecting duct acid secretion_Homo sapiens_hsa049660.89093295
71Renin secretion_Homo sapiens_hsa049240.88610978
72Systemic lupus erythematosus_Homo sapiens_hsa053220.87383267
73Pentose phosphate pathway_Homo sapiens_hsa000300.85949940
74Fanconi anemia pathway_Homo sapiens_hsa034600.84947832
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84575111
76Histidine metabolism_Homo sapiens_hsa003400.84486141
77Serotonergic synapse_Homo sapiens_hsa047260.83993090
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81917048
79Fat digestion and absorption_Homo sapiens_hsa049750.81790729
80Insulin secretion_Homo sapiens_hsa049110.81761885
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80757656
82Sulfur metabolism_Homo sapiens_hsa009200.80254529
83Circadian entrainment_Homo sapiens_hsa047130.80209467
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.80163345
85Insulin signaling pathway_Homo sapiens_hsa049100.79135028
86Selenocompound metabolism_Homo sapiens_hsa004500.78898497
87Insulin resistance_Homo sapiens_hsa049310.78891814
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78448519
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76571201
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76093983
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75070532
92Glycerolipid metabolism_Homo sapiens_hsa005610.74962821
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74812912
94Parkinsons disease_Homo sapiens_hsa050120.74261735
95Alcoholism_Homo sapiens_hsa050340.73810237
96Morphine addiction_Homo sapiens_hsa050320.71520787
97Basal transcription factors_Homo sapiens_hsa030220.71025525
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70871237
99Steroid biosynthesis_Homo sapiens_hsa001000.69636519
100Calcium signaling pathway_Homo sapiens_hsa040200.69594532
101Basal cell carcinoma_Homo sapiens_hsa052170.69511544
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69371075
103Tyrosine metabolism_Homo sapiens_hsa003500.69082639
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67579595
105Oxytocin signaling pathway_Homo sapiens_hsa049210.67278146
106Arginine and proline metabolism_Homo sapiens_hsa003300.62500683
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62433204
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62154837
109ABC transporters_Homo sapiens_hsa020100.61651036
110ECM-receptor interaction_Homo sapiens_hsa045120.61609845
111Salivary secretion_Homo sapiens_hsa049700.61470414
112Complement and coagulation cascades_Homo sapiens_hsa046100.61080454
113Glutamatergic synapse_Homo sapiens_hsa047240.59163736
114Galactose metabolism_Homo sapiens_hsa000520.58711787
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57808308
116Alzheimers disease_Homo sapiens_hsa050100.57463238
117Synaptic vesicle cycle_Homo sapiens_hsa047210.55605397
118Olfactory transduction_Homo sapiens_hsa047400.52691930
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50873492
120Hedgehog signaling pathway_Homo sapiens_hsa043400.50841519
121Cholinergic synapse_Homo sapiens_hsa047250.50698198
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50355442
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50183332
124Gastric acid secretion_Homo sapiens_hsa049710.49489987
125Huntingtons disease_Homo sapiens_hsa050160.49104182
126Gap junction_Homo sapiens_hsa045400.48863034
127Retinol metabolism_Homo sapiens_hsa008300.48237647
128Type II diabetes mellitus_Homo sapiens_hsa049300.45961559
129Hippo signaling pathway_Homo sapiens_hsa043900.45532959
130Phenylalanine metabolism_Homo sapiens_hsa003600.41818654
131Vitamin digestion and absorption_Homo sapiens_hsa049770.40440096
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40189985
133Axon guidance_Homo sapiens_hsa043600.39583530
134Dorso-ventral axis formation_Homo sapiens_hsa043200.39521452
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38855192
136Melanogenesis_Homo sapiens_hsa049160.38034598
137cAMP signaling pathway_Homo sapiens_hsa040240.35701386
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.35551610
139Mineral absorption_Homo sapiens_hsa049780.35035879
140Focal adhesion_Homo sapiens_hsa045100.34232988

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