SOX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.67970319
2endothelium development (GO:0003158)7.05882058
3vascular endothelial growth factor signaling pathway (GO:0038084)6.86406667
4retina vasculature morphogenesis in camera-type eye (GO:0061299)6.35206427
5positive regulation of vasculogenesis (GO:2001214)6.34494692
6lymphangiogenesis (GO:0001946)6.09694426
7regulation of vasculogenesis (GO:2001212)5.64984297
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.62120002
9surfactant homeostasis (GO:0043129)5.41904278
10blood vessel maturation (GO:0001955)5.02737056
11endothelial cell differentiation (GO:0045446)5.01270017
12vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.91099523
13regulation of endothelial cell differentiation (GO:0045601)4.84695830
14regulation of cardioblast differentiation (GO:0051890)4.80619958
15basement membrane organization (GO:0071711)4.80303597
16endothelial tube morphogenesis (GO:0061154)4.76193648
17morphogenesis of an endothelium (GO:0003159)4.76193648
18atrial cardiac muscle cell action potential (GO:0086014)4.74578307
19heart trabecula formation (GO:0060347)4.64976623
20chemical homeostasis within a tissue (GO:0048875)4.51889529
21gap junction assembly (GO:0016264)4.46726849
22angiogenesis involved in wound healing (GO:0060055)4.45780511
23embryonic heart tube development (GO:0035050)4.38917493
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.29035399
25patterning of blood vessels (GO:0001569)4.28168374
26keratinization (GO:0031424)4.24747562
27sprouting angiogenesis (GO:0002040)4.21710518
28atrioventricular valve morphogenesis (GO:0003181)4.20433143
29peptidyl-tyrosine autophosphorylation (GO:0038083)4.13795558
30endothelial cell morphogenesis (GO:0001886)4.08853625
31transcytosis (GO:0045056)4.00068811
32heart valve formation (GO:0003188)3.95250781
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.91034710
34embryonic foregut morphogenesis (GO:0048617)3.85074720
35cell migration involved in sprouting angiogenesis (GO:0002042)3.83841948
36ovulation from ovarian follicle (GO:0001542)3.83764865
37glomerular filtration (GO:0003094)3.80460184
38regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.79264645
39negative regulation of protein localization to cell surface (GO:2000009)3.74760170
40positive regulation of glycolytic process (GO:0045821)3.72517721
41vasculogenesis (GO:0001570)3.71187658
42negative regulation of cell fate specification (GO:0009996)3.69480740
43positive regulation of respiratory burst (GO:0060267)3.66721345
44ventricular trabecula myocardium morphogenesis (GO:0003222)3.66151509
45regulation of actin filament-based movement (GO:1903115)3.59547148
46cardiac myofibril assembly (GO:0055003)3.57813187
47regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.57284988
48hemidesmosome assembly (GO:0031581)3.55874619
49negative regulation of blood vessel endothelial cell migration (GO:0043537)3.54382608
50venous blood vessel morphogenesis (GO:0048845)3.52485044
51renal filtration (GO:0097205)3.50234028
52regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.49087604
53regulation of cardiac muscle cell contraction (GO:0086004)3.48751630
54substrate-dependent cell migration (GO:0006929)3.48189987
55blood vessel endothelial cell migration (GO:0043534)3.47768984
56negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.44517314
57heart trabecula morphogenesis (GO:0061384)3.44026100
58negative regulation of endothelial cell migration (GO:0010596)3.43652384
59Notch signaling involved in heart development (GO:0061314)3.41789571
60platelet dense granule organization (GO:0060155)3.40467378
61wound healing, spreading of epidermal cells (GO:0035313)3.34673186
62endothelial cell proliferation (GO:0001935)3.34365080
63exocrine pancreas development (GO:0031017)3.29522570
64trabecula morphogenesis (GO:0061383)3.27752610
65establishment of skin barrier (GO:0061436)3.23454756
66trabecula formation (GO:0060343)3.22664362
67* endoderm formation (GO:0001706)3.21484860
68positive regulation of endothelial cell differentiation (GO:0045603)3.21064967
69ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.20254428
70thrombin receptor signaling pathway (GO:0070493)3.08875754
71negative regulation of Rho protein signal transduction (GO:0035024)3.06063560
72negative regulation of epithelial cell migration (GO:0010633)3.05838023
73regulation of sarcomere organization (GO:0060297)3.05382437
74desmosome organization (GO:0002934)3.03992441
75sarcomere organization (GO:0045214)3.03000335
76myofibril assembly (GO:0030239)3.02565828
77blood vessel remodeling (GO:0001974)3.01297533
78polarized epithelial cell differentiation (GO:0030859)3.01118950
79L-fucose metabolic process (GO:0042354)2.98664715
80L-fucose catabolic process (GO:0042355)2.98664715
81fucose catabolic process (GO:0019317)2.98664715
82cardiac muscle tissue morphogenesis (GO:0055008)2.97394107
83establishment of endothelial barrier (GO:0061028)2.96399233
84regulation of mesoderm development (GO:2000380)2.95214872
85negative regulation of endothelial cell apoptotic process (GO:2000352)2.94773457
86regulation of endothelial cell migration (GO:0010594)2.92403767
87keratinocyte proliferation (GO:0043616)2.92210287
88morphogenesis of an epithelial sheet (GO:0002011)2.92168990
89regulation of establishment or maintenance of cell polarity (GO:0032878)2.91865672
90mRNA transcription from RNA polymerase II promoter (GO:0042789)2.91421511
91positive regulation of protein kinase C signaling (GO:0090037)2.89709492
92blood vessel morphogenesis (GO:0048514)2.86040812
93heparin biosynthetic process (GO:0030210)2.85347330
94heparin metabolic process (GO:0030202)2.85347330
95regulation of vascular permeability (GO:0043114)2.82781708
96positive regulation of focal adhesion assembly (GO:0051894)2.81183596
97positive regulation of cell junction assembly (GO:1901890)2.81183596
98cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77956859
99plasma membrane repair (GO:0001778)2.77525295
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76089663
101cardiac muscle hypertrophy (GO:0003300)2.74269499
102phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73030492
103positive regulation of urine volume (GO:0035810)2.72973959
104positive regulation of glomerulus development (GO:0090193)2.72051765
105negative regulation of cell fate commitment (GO:0010454)2.70911837
106artery development (GO:0060840)2.70852270
107cardiac muscle cell action potential involved in contraction (GO:0086002)2.70738097
108keratinocyte development (GO:0003334)2.69229000
109regulation of sequestering of triglyceride (GO:0010889)2.69099565
110cardiac muscle cell action potential (GO:0086001)2.68972429
111dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68660369
112negative regulation of nitric-oxide synthase activity (GO:0051001)2.67009635
113muscle tissue morphogenesis (GO:0060415)2.66256716
114negative regulation of keratinocyte proliferation (GO:0010839)2.66088785
115regulation of blood vessel endothelial cell migration (GO:0043535)2.66031626
116cell migration involved in heart development (GO:0060973)2.63653200
117heart valve morphogenesis (GO:0003179)2.62971563
118substrate adhesion-dependent cell spreading (GO:0034446)2.62900663
119cardiac right ventricle morphogenesis (GO:0003215)2.62784336
120positive regulation of endothelial cell proliferation (GO:0001938)2.62445606
121striated muscle hypertrophy (GO:0014897)2.61312787
122positive regulation of adherens junction organization (GO:1903393)2.61088201
123negative regulation of platelet activation (GO:0010544)2.60383717
124response to pheromone (GO:0019236)2.60333687
125mRNA transcription (GO:0009299)2.59745645
126sodium-independent organic anion transport (GO:0043252)2.59470935
127endothelial cell migration (GO:0043542)2.59279463
128organ formation (GO:0048645)2.59168824
129angiogenesis (GO:0001525)2.58655476
130endocardial cushion development (GO:0003197)2.57721231
131renal system development (GO:0072001)2.57404908
132nephron epithelium development (GO:0072009)2.50816379
133negative regulation of systemic arterial blood pressure (GO:0003085)2.49378660
134cornea development in camera-type eye (GO:0061303)2.46233011
135smooth muscle tissue development (GO:0048745)2.46133558
136negative regulation of protein autophosphorylation (GO:0031953)2.46081893
137negative regulation of DNA biosynthetic process (GO:2000279)2.45039928
138ventricular septum development (GO:0003281)2.44470316
139positive regulation of glycogen biosynthetic process (GO:0045725)2.42119741
140regulation of water loss via skin (GO:0033561)2.41381168
141protein heterotetramerization (GO:0051290)2.39011448
142positive regulation of action potential (GO:0045760)2.36822866
143regulation of action potential (GO:0098900)2.33358041
144regulation of hippo signaling (GO:0035330)2.32847366
145calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32045836
146cAMP biosynthetic process (GO:0006171)2.32009489
147phosphatidylserine acyl-chain remodeling (GO:0036150)2.31588258
148cardiac ventricle morphogenesis (GO:0003208)2.30391573
149regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30115042
150regulation of synapse maturation (GO:0090128)2.29473689
151auditory receptor cell stereocilium organization (GO:0060088)2.27840039
152inner ear receptor stereocilium organization (GO:0060122)2.26839600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.07104017
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.95045233
3VDR_22108803_ChIP-Seq_LS180_Human3.38524252
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03721195
5GATA2_21666600_ChIP-Seq_HMVEC_Human2.99355026
6ZNF274_21170338_ChIP-Seq_K562_Hela2.68984830
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.60442000
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57614415
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.48919871
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45271350
11GBX2_23144817_ChIP-Seq_PC3_Human2.39970530
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38613007
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.30594547
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18480607
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.07366402
16* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.04434069
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01324436
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00542649
19CLOCK_20551151_ChIP-Seq_293T_Human1.95032078
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93794699
21ZNF263_19887448_ChIP-Seq_K562_Human1.92889562
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90954118
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89395272
24* EED_16625203_ChIP-ChIP_MESCs_Mouse1.83278493
25P300_19829295_ChIP-Seq_ESCs_Human1.82542956
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79242256
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75215860
28CJUN_26792858_Chip-Seq_BT549_Human1.74320923
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.73553180
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.72765405
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69872622
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68582439
33* TBX20_22328084_ChIP-Seq_HEART_Mouse1.66602137
34* TBX20_22080862_ChIP-Seq_HEART_Mouse1.66602137
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65876648
36* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64113259
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63864779
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.63286975
39FUS_26573619_Chip-Seq_HEK293_Human1.62261535
40TAF15_26573619_Chip-Seq_HEK293_Human1.62113657
41IGF1R_20145208_ChIP-Seq_DFB_Human1.60309340
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.56398704
43* EZH2_27304074_Chip-Seq_ESCs_Mouse1.55576733
44* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52622709
45* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52622709
46* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52272324
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.49909234
48TCF4_22108803_ChIP-Seq_LS180_Human1.49513783
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.48304211
50SMAD4_21799915_ChIP-Seq_A2780_Human1.47003507
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46566600
52AR_25329375_ChIP-Seq_VCAP_Human1.46260274
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45307925
54EWS_26573619_Chip-Seq_HEK293_Human1.45304068
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.43329035
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43304433
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42893274
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42299875
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41022497
60* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38950680
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38903074
62AHR_22903824_ChIP-Seq_MCF-7_Human1.38428704
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37769688
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36935537
65TP53_18474530_ChIP-ChIP_U2OS_Human1.36373180
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36358097
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35687297
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34749284
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34153349
70SOX2_20726797_ChIP-Seq_SW620_Human1.33942549
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.33808680
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32983359
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29449904
74* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27622517
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.26998237
76* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26017983
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25812467
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.25449627
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25422073
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25309607
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.23794134
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23690895
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23673006
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.23530766
85* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23419370
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22392596
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22392596
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.20906369
89CDX2_22108803_ChIP-Seq_LS180_Human1.19873349
90ER_23166858_ChIP-Seq_MCF-7_Human1.19568573
91RUNX2_22187159_ChIP-Seq_PCA_Human1.18191857
92STAT3_23295773_ChIP-Seq_U87_Human1.17787652
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17720701
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.17311179
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.17294311
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17276690
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17183402
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16658358
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16481455
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15994068
101NANOG_19829295_ChIP-Seq_ESCs_Human1.15913026
102SOX2_19829295_ChIP-Seq_ESCs_Human1.15913026
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15532616
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15532616
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15233796
106* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14604271
107CBP_20019798_ChIP-Seq_JUKART_Human1.14594786
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14594786
109RXR_22108803_ChIP-Seq_LS180_Human1.14379376
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14210436
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13821619
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13642654
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13616436
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11944318
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11537395
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.11493626
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11427745
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10614166
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10262731
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10101835
121TCF4_23295773_ChIP-Seq_U87_Human1.09329543
122* RNF2_27304074_Chip-Seq_ESCs_Mouse1.08952315
123TP53_16413492_ChIP-PET_HCT116_Human1.07939419
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07242790
125BCAT_22108803_ChIP-Seq_LS180_Human1.06163783
126* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05385397
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05303957
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05303957
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05303957
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.03149568
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02521686
132* TP53_20018659_ChIP-ChIP_R1E_Mouse1.02410485
133CBX2_27304074_Chip-Seq_ESCs_Mouse1.02069289
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01875603
135AR_20517297_ChIP-Seq_VCAP_Human1.01786850
136JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01681918
137* EZH2_27294783_Chip-Seq_ESCs_Mouse1.01313040
138BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01102151
139SMAD4_21741376_ChIP-Seq_HESCs_Human1.00968960
140* GATA1_19941826_ChIP-Seq_K562_Human1.00854219
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99512595
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99337874
143TP63_23658742_ChIP-Seq_EP156T_Human0.98230704
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97561969
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.97561969
146* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96980848
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95730595
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95581289
149AR_21572438_ChIP-Seq_LNCaP_Human0.95206677
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95202376
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94809727
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.94644489
153* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94515628
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.93833725
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.93593291
156MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93527954
157BRD4_25478319_ChIP-Seq_HGPS_Human0.92839268
158ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90046179
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89353110
160KDM2B_26808549_Chip-Seq_K562_Human0.89034571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.86065292
2MP0001879_abnormal_lymphatic_vessel5.76798935
3MP0004272_abnormal_basement_membrane5.44702915
4MP0005167_abnormal_blood-brain_barrier4.41945587
5MP0003828_pulmonary_edema3.58156495
6MP0004084_abnormal_cardiac_muscle3.18982624
7MP0005623_abnormal_meninges_morphology3.15602975
8MP0004215_abnormal_myocardial_fiber2.83456923
9MP0006138_congestive_heart_failure2.75929315
10MP0003724_increased_susceptibility_to2.44914102
11MP0006054_spinal_hemorrhage2.32160362
12MP0000767_abnormal_smooth_muscle2.12613719
13MP0005330_cardiomyopathy2.11659292
14MP0005084_abnormal_gallbladder_morpholo2.07671821
15MP0004484_altered_response_of2.03334444
16MP0003941_abnormal_skin_development1.99257067
17MP0004885_abnormal_endolymph1.98985866
18MP0004036_abnormal_muscle_relaxation1.93910632
19MP0003279_aneurysm1.87805164
20MP0002972_abnormal_cardiac_muscle1.82150637
21MP0002127_abnormal_cardiovascular_syste1.81109359
22MP0001544_abnormal_cardiovascular_syste1.80056926
23MP0005385_cardiovascular_system_phenoty1.80056926
24MP0002837_dystrophic_cardiac_calcinosis1.79163382
25MP0010630_abnormal_cardiac_muscle1.79124214
26MP0002796_impaired_skin_barrier1.71156196
27MP0008775_abnormal_heart_ventricle1.65164464
28MP0003195_calcinosis1.64498776
29MP0000467_abnormal_esophagus_morphology1.62486113
30MP0002332_abnormal_exercise_endurance1.58691475
31MP0004085_abnormal_heartbeat1.58035861
32MP0005165_increased_susceptibility_to1.57202528
33MP0000751_myopathy1.57041460
34MP0005275_abnormal_skin_tensile1.57025945
35MP0003705_abnormal_hypodermis_morpholog1.47091164
36MP0005595_abnormal_vascular_smooth1.45110508
37MP0005620_abnormal_muscle_contractility1.42994740
38MP0001958_emphysema1.41996760
39MP0002925_abnormal_cardiovascular_devel1.38639492
40MP0000579_abnormal_nail_morphology1.37923045
41MP0000427_abnormal_hair_cycle1.37737350
42MP0003011_delayed_dark_adaptation1.34959916
43MP0002128_abnormal_blood_circulation1.34525473
44MP0003566_abnormal_cell_adhesion1.33798181
45MP0003950_abnormal_plasma_membrane1.30548545
46MP0004147_increased_porphyrin_level1.30211912
47MP0002638_abnormal_pupillary_reflex1.29941915
48MP0004087_abnormal_muscle_fiber1.27329811
49MP0002295_abnormal_pulmonary_circulatio1.25437965
50MP0009379_abnormal_foot_pigmentation1.23316155
51MP0005171_absent_coat_pigmentation1.23169960
52MP0003567_abnormal_fetal_cardiomyocyte1.23072378
53MP0005451_abnormal_body_composition1.21234752
54MP0008438_abnormal_cutaneous_collagen1.20233785
55MP0010234_abnormal_vibrissa_follicle1.20026989
56MP0000249_abnormal_blood_vessel1.19211348
57MP0001614_abnormal_blood_vessel1.18871239
58MP0002138_abnormal_hepatobiliary_system1.18269012
59MP0009384_cardiac_valve_regurgitation1.16498347
60MP0005409_darkened_coat_color1.15256252
61MP0000749_muscle_degeneration1.14380343
62MP0002098_abnormal_vibrissa_morphology1.11668865
63MP0001915_intracranial_hemorrhage1.11548029
64MP0005670_abnormal_white_adipose1.09278227
65MP0005365_abnormal_bile_salt1.08848547
66MP0001784_abnormal_fluid_regulation1.07654662
67MP0000266_abnormal_heart_morphology1.05356159
68MP0000343_altered_response_to1.04350186
69MP0004782_abnormal_surfactant_physiolog1.04347127
70MP0005501_abnormal_skin_physiology1.02868124
71MP0002234_abnormal_pharynx_morphology1.01099997
72MP0000647_abnormal_sebaceous_gland1.00845887
73MP0000013_abnormal_adipose_tissue0.97135771
74MP0003385_abnormal_body_wall0.96395312
75MP0005187_abnormal_penis_morphology0.95552556
76MP0005164_abnormal_response_to0.94751702
77MP0004043_abnormal_pH_regulation0.92642463
78MP0006276_abnormal_autonomic_nervous0.92006585
79MP0000750_abnormal_muscle_regeneration0.91244119
80MP0002133_abnormal_respiratory_system0.90892932
81MP0005388_respiratory_system_phenotype0.90892932
82MP0005551_abnormal_eye_electrophysiolog0.90369564
83MP0004883_abnormal_blood_vessel0.90294092
84MP0003091_abnormal_cell_migration0.89853130
85MP0000003_abnormal_adipose_tissue0.89245573
86MP0003943_abnormal_hepatobiliary_system0.88585045
87MP0000516_abnormal_urinary_system0.88403861
88MP0005367_renal/urinary_system_phenotyp0.88403861
89MP0002933_joint_inflammation0.86709380
90MP0003137_abnormal_impulse_conducting0.84919628
91MP0004130_abnormal_muscle_cell0.81193390
92MP0006072_abnormal_retinal_apoptosis0.80051164
93MP0000049_abnormal_middle_ear0.79305951
94MP0002102_abnormal_ear_morphology0.79263532
95MP0002106_abnormal_muscle_physiology0.79211372
96MP0000537_abnormal_urethra_morphology0.78100427
97MP0001661_extended_life_span0.77794892
98MP0010771_integument_phenotype0.76983421
99MP0005253_abnormal_eye_physiology0.76423370
100MP0003646_muscle_fatigue0.76324834
101MP0010678_abnormal_skin_adnexa0.76099263
102MP0005369_muscle_phenotype0.75029710
103MP0001851_eye_inflammation0.74145808
104MP0002108_abnormal_muscle_morphology0.74067795
105MP0002876_abnormal_thyroid_physiology0.71845651
106MP0000762_abnormal_tongue_morphology0.71439653
107MP0003122_maternal_imprinting0.71400282
108MP0001216_abnormal_epidermal_layer0.70933555
109MP0003221_abnormal_cardiomyocyte_apopto0.70536764
110MP0009278_abnormal_bone_marrow0.70429018
111MP0000230_abnormal_systemic_arterial0.70296861
112MP0003119_abnormal_digestive_system0.70201799
113MP0009764_decreased_sensitivity_to0.69425036
114MP0000465_gastrointestinal_hemorrhage0.69186393
115MP0010030_abnormal_orbit_morphology0.68716448
116MP0003935_abnormal_craniofacial_develop0.68642475
117MP0001188_hyperpigmentation0.67847006
118MP0003984_embryonic_growth_retardation0.66430986
119MP0001191_abnormal_skin_condition0.65959179
120MP0004145_abnormal_muscle_electrophysio0.64904242
121MP0002088_abnormal_embryonic_growth/wei0.64773955
122MP0002086_abnormal_extraembryonic_tissu0.62456556
123MP0004133_heterotaxia0.61700668
124MP0002254_reproductive_system_inflammat0.61582712
125MP0001501_abnormal_sleep_pattern0.59038135
126MP0009250_abnormal_appendicular_skeleto0.58193427
127MP0002249_abnormal_larynx_morphology0.57996705
128MP0008004_abnormal_stomach_pH0.57884734
129MP0000383_abnormal_hair_follicle0.57490573
130MP0002060_abnormal_skin_morphology0.57247138
131MP0000377_abnormal_hair_follicle0.56438970
132MP0005375_adipose_tissue_phenotype0.54555262
133MP0005410_abnormal_fertilization0.53255272

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)5.76633851
2Ventricular tachycardia (HP:0004756)5.15604787
3Polycythemia (HP:0001901)5.14379317
4Sudden death (HP:0001699)4.80069466
5Muscle fiber splitting (HP:0003555)4.65199534
6Right ventricular cardiomyopathy (HP:0011663)4.51315257
7Atrial fibrillation (HP:0005110)4.42774660
8Exercise-induced muscle cramps (HP:0003710)4.15865213
9Supraventricular arrhythmia (HP:0005115)4.15476944
10Primary atrial arrhythmia (HP:0001692)4.04570017
11Hematochezia (HP:0002573)3.96831553
12Enlarged penis (HP:0000040)3.96668389
13Supraventricular tachycardia (HP:0004755)3.80707616
14Esophageal varix (HP:0002040)3.80133830
15Spontaneous hematomas (HP:0007420)3.77738341
16Alopecia of scalp (HP:0002293)3.72124825
17Hyporeflexia of lower limbs (HP:0002600)3.52303960
18Increased connective tissue (HP:0009025)3.35579533
19Hypoplasia of the iris (HP:0007676)3.34347648
20Reduced subcutaneous adipose tissue (HP:0003758)3.33413708
21Lymphangioma (HP:0100764)3.32181820
22Plantar hyperkeratosis (HP:0007556)3.27435167
23Palmoplantar hyperkeratosis (HP:0000972)3.27324647
24Long foot (HP:0001833)3.21299382
25Lipoatrophy (HP:0100578)3.21020632
26Palmar hyperkeratosis (HP:0010765)3.10929563
27Cerebral aneurysm (HP:0004944)3.08308847
28Nonimmune hydrops fetalis (HP:0001790)3.07416505
29Aplasia cutis congenita (HP:0001057)2.97355904
30Pancreatic islet-cell hyperplasia (HP:0004510)2.97216493
31Porencephaly (HP:0002132)2.96729552
32Hypoglycemic coma (HP:0001325)2.95749456
33Absent hand (HP:0004050)2.94067183
34Distal lower limb muscle weakness (HP:0009053)2.93107681
35Cerebral hemorrhage (HP:0001342)2.90892493
36Abnormality of nail color (HP:0100643)2.90420743
37Pulmonary artery stenosis (HP:0004415)2.83678823
38Adactyly (HP:0009776)2.82859488
39Broad metatarsal (HP:0001783)2.81181816
40Delayed CNS myelination (HP:0002188)2.80098883
41Calf muscle hypertrophy (HP:0008981)2.78103890
42Abnormality of the calf musculature (HP:0001430)2.76675451
43Congenital stationary night blindness (HP:0007642)2.76308582
44Syncope (HP:0001279)2.75900732
45Insulin-resistant diabetes mellitus (HP:0000831)2.74627115
46Portal hypertension (HP:0001409)2.74559513
47Hypoplastic left heart (HP:0004383)2.73314569
48Difficulty running (HP:0009046)2.71062495
49Spinal rigidity (HP:0003306)2.70035243
50Prolonged QT interval (HP:0001657)2.69197908
51Skull defect (HP:0001362)2.68728007
52Fragile nails (HP:0001808)2.67313327
53Type II lissencephaly (HP:0007260)2.62382462
54Ketoacidosis (HP:0001993)2.62189782
55EMG: myopathic abnormalities (HP:0003458)2.61631073
56Duplicated collecting system (HP:0000081)2.60913297
57Hyperinsulinemic hypoglycemia (HP:0000825)2.59828173
58Erythroderma (HP:0001019)2.58955512
59Hypoglycemic seizures (HP:0002173)2.58499914
60Dilated cardiomyopathy (HP:0001644)2.54078907
61Onycholysis (HP:0001806)2.53687514
62Hyperventilation (HP:0002883)2.51356406
63Premature rupture of membranes (HP:0001788)2.48457058
64Muscle hypertrophy of the lower extremities (HP:0008968)2.48248454
65Short hallux (HP:0010109)2.46803305
66Facial diplegia (HP:0001349)2.45803171
67Hydroureter (HP:0000072)2.45627682
68Absent eyebrow (HP:0002223)2.43161740
69Abnormality of the hepatic vasculature (HP:0006707)2.42271998
70Symptomatic seizures (HP:0011145)2.41163796
71Neonatal death (HP:0003811)2.41161606
72Hemorrhage of the eye (HP:0011885)2.41061390
73Visceral angiomatosis (HP:0100761)2.40227242
74Abnormality of the renal collecting system (HP:0004742)2.38019426
75Congenital, generalized hypertrichosis (HP:0004540)2.36935014
76Abnormality of the left ventricular outflow tract (HP:0011103)2.36189556
77Subaortic stenosis (HP:0001682)2.36189556
78Pancreatic cysts (HP:0001737)2.34354319
79Exercise-induced myalgia (HP:0003738)2.33197488
80Capillary hemangiomas (HP:0005306)2.31893475
81Wrist flexion contracture (HP:0001239)2.31861729
82Abnormality of the renal cortex (HP:0011035)2.31043889
83Diaphragmatic weakness (HP:0009113)2.29423937
84Hemangiomatosis (HP:0007461)2.27016776
85Atrioventricular block (HP:0001678)2.25272821
86Myotonia (HP:0002486)2.23796789
87Hypotrichosis (HP:0001006)2.23187467
88Abnormality of the nasal mucosa (HP:0000433)2.21836411
89Hyperglycemia (HP:0003074)2.21440341
90Muscle stiffness (HP:0003552)2.20734950
91Abnormality of the axillary hair (HP:0100134)2.20497066
92Abnormality of secondary sexual hair (HP:0009888)2.20497066
93Bulbous nose (HP:0000414)2.19951506
94Palpitations (HP:0001962)2.18179318
95Aplasia/Hypoplasia of the hallux (HP:0008362)2.16217354
96Keratoconus (HP:0000563)2.16125713
97Increased corneal curvature (HP:0100692)2.16125713
98Elfin facies (HP:0004428)2.16031598
99Advanced eruption of teeth (HP:0006288)2.14535608
100Tubular atrophy (HP:0000092)2.12635449
101Increased variability in muscle fiber diameter (HP:0003557)2.12055304
102Abnormality of midbrain morphology (HP:0002418)2.10557937
103Molar tooth sign on MRI (HP:0002419)2.10557937
104Ventricular fibrillation (HP:0001663)2.09921042
105Cavernous hemangioma (HP:0001048)2.09091609
106Abnormality of the renal medulla (HP:0100957)2.07444656
107Hypoplastic heart (HP:0001961)2.03658318
108Palmoplantar keratoderma (HP:0000982)2.03460672
109Ventricular arrhythmia (HP:0004308)2.02153496
110Abnormality of the pancreatic islet cells (HP:0006476)2.02106661
111Abnormality of endocrine pancreas physiology (HP:0012093)2.02106661
112Growth hormone excess (HP:0000845)2.01381270
113Abnormal umbilical cord blood vessels (HP:0011403)2.01270515
114Single umbilical artery (HP:0001195)2.01270515
115Abnormality of the fetal cardiovascular system (HP:0010948)2.01270515
116Conjunctival telangiectasia (HP:0000524)2.00741631
117Absent hair (HP:0002298)2.00081291
118Aneurysm (HP:0002617)1.99635492
119Nephronophthisis (HP:0000090)1.98249481
120Abnormal atrioventricular conduction (HP:0005150)1.98201777
121Epidermoid cyst (HP:0200040)1.97992888
122Pancreatic fibrosis (HP:0100732)1.97042297
123Congenital malformation of the right heart (HP:0011723)1.96483321
124Double outlet right ventricle (HP:0001719)1.96483321
125Hemiplegia (HP:0002301)1.96229082
126Abnormality of skeletal muscle fiber size (HP:0012084)1.95716244
127Acanthosis nigricans (HP:0000956)1.93932107
128Ectropion (HP:0000656)1.93826407
129Congenital ichthyosiform erythroderma (HP:0007431)1.93693918
130Heart block (HP:0012722)1.93652105
131Parakeratosis (HP:0001036)1.93207533
132Myoglobinuria (HP:0002913)1.93081247
133Absent eyelashes (HP:0000561)1.92819258
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91768087
135Venous insufficiency (HP:0005293)1.91570750
136Furrowed tongue (HP:0000221)1.89772216
137Preauricular pit (HP:0004467)1.89116717
138Periauricular skin pits (HP:0100277)1.89116717
139Attenuation of retinal blood vessels (HP:0007843)1.88645890
140Deep venous thrombosis (HP:0002625)1.88586252
141Fair hair (HP:0002286)1.88478562
142Pendular nystagmus (HP:0012043)1.88304781
143True hermaphroditism (HP:0010459)1.87857693
144Pigmentary retinal degeneration (HP:0001146)1.86975370
145Pulmonary hypertension (HP:0002092)1.84865238
146Widely spaced teeth (HP:0000687)1.83903791
147Skin pits (HP:0100276)1.83854275
148Decreased central vision (HP:0007663)1.82811012
149Erythema (HP:0010783)1.81642713
150Shallow orbits (HP:0000586)1.81404550
151Absent toe (HP:0010760)1.81168104
152Hip contracture (HP:0003273)1.79911903
153Exotropia (HP:0000577)1.79821384
154Congenital hepatic fibrosis (HP:0002612)1.79552510
155Venous abnormality (HP:0002624)1.78647706
156Areflexia of lower limbs (HP:0002522)1.78585430
157Woolly hair (HP:0002224)1.78511852
158Occipital encephalocele (HP:0002085)1.77272750
159Hypoplasia of the uterus (HP:0000013)1.76603031
160Distal arthrogryposis (HP:0005684)1.76208921
161Broad-based gait (HP:0002136)1.75895083
162Cerebellar dysplasia (HP:0007033)1.75314822
163Abolished electroretinogram (ERG) (HP:0000550)1.73331582
164Nail dystrophy (HP:0008404)1.72760693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.03278298
2TGFBR22.97360717
3EPHB22.71611080
4TGFBR12.62990968
5FRK2.37365144
6GRK12.35702587
7MAP4K22.03963358
8TIE110.9059631
9DMPK1.95810295
10FER1.87753054
11PTK2B1.82090503
12INSRR1.64745973
13RIPK11.60757242
14PINK11.59311354
15MYLK1.57093691
16TTN1.54697287
17ADRBK21.52842122
18LATS11.36407656
19AKT31.29130069
20WNK31.22309195
21MAP3K31.21248774
22PTK61.14736155
23FLT31.13115845
24PDK21.05671164
25PRKD10.97453732
26OBSCN0.95864143
27MAPK120.92034106
28BCR0.88358849
29EPHB10.83740297
30LATS20.81532245
31PDGFRA0.80990876
32PHKG20.80950305
33PHKG10.80950305
34PRKG20.78990764
35PRKAA20.78184422
36MAP2K30.77738543
37FGFR40.77114114
38OXSR10.75467854
39ACVR1B0.75451235
40TEC0.74932863
41ADRBK10.74316802
42MAPKAPK30.73946119
43LMTK20.73639424
44TRIM280.71739275
45BMPR1B0.69076656
46PTK20.68730090
47CAMK1G0.68202437
48PRKCE0.68126941
49TLK10.67643498
50ZAK0.65447482
51CSNK1G10.63566843
52MAPK130.61838780
53NTRK10.61429016
54PKN20.61305916
55MAP3K140.59827530
56PRKD30.59350964
57PLK20.58053260
58PIK3CA0.54480379
59EPHA20.54017757
60MST40.53822058
61LRRK20.53677880
62GRK50.52211371
63IGF1R0.51999320
64NUAK10.51801048
65MKNK20.50885642
66WNK10.50781606
67ROCK10.50468100
68CSK0.49937415
69PAK40.49347245
70MAPK70.48164246
71WNK40.47985086
72CSNK1G30.47697571
73EPHA30.46271688
74TAOK30.46238907
75NEK90.46180848
76CASK0.44219183
77STK100.43933045
78PRKCH0.43856217
79EIF2AK30.43846373
80PIK3CG0.43743631
81MET0.43127191
82MAPKAPK50.43034778
83MAPK150.42177843
84STK240.42050713
85ERBB30.41781967
86PAK30.41564424
87TRPM70.40013160
88FGR0.39550146
89PDGFRB0.39336341
90DAPK20.39303658
91CSNK1G20.39281564
92NLK0.38976597
93MAP3K10.37676665
94STK30.36314735
95MAP2K10.36210923
96FGFR30.34784328
97MAP3K70.34611155
98ROCK20.33619966
99MARK30.33160851
100SRC0.33112925
101MAP2K20.32575698
102CAMK40.32468463
103EGFR0.32052611
104SIK10.31496320
105MKNK10.30270162
106PDK30.29148660
107PDK40.29148660
108GSK3A0.28860896
109AKT20.28775029
110TRIB30.28609994
111FGFR20.27690041
112CLK10.27118621
113STK38L0.26732716
114TAF10.26641348
115CAMK10.25689016
116CAMK1D0.25598946
117STK390.24802402
118DDR20.24447318
119INSR0.24234102
120NME10.23574028
121TBK10.23549142
122PKN10.23317570
123PRKAA10.23206077
124CDK80.21575144
125STK110.21036596
126ERN10.20235219
127PRKD20.20170864
128MST1R0.18609769
129CDC42BPA0.18241826
130IKBKB0.18161058
131ILK0.18139476
132PRKACB0.17837341
133MAP3K40.17723030
134CAMK2D0.17251304
135FES0.16806127
136CAMK2A0.16778044
137ABL10.16443199
138CSNK1A1L0.16151943
139PRKACA0.14522140
140ABL20.14505540
141MUSK0.14423515
142BRSK20.14187863
143PRKG10.14139041
144MAP2K60.13616459
145CSNK1A10.12223566
146MAP3K90.11810689
147PRKCA0.10716033

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.26230648
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.99445094
3Linoleic acid metabolism_Homo sapiens_hsa005912.80503739
4Dilated cardiomyopathy_Homo sapiens_hsa054142.71824923
5Adherens junction_Homo sapiens_hsa045202.68953298
6Focal adhesion_Homo sapiens_hsa045102.67578236
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.65410491
8Phototransduction_Homo sapiens_hsa047442.46730914
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37010194
10Leukocyte transendothelial migration_Homo sapiens_hsa046702.25792919
11Ether lipid metabolism_Homo sapiens_hsa005652.25257861
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10126641
13Small cell lung cancer_Homo sapiens_hsa052222.01166249
14Circadian rhythm_Homo sapiens_hsa047101.99586752
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90786436
16Rap1 signaling pathway_Homo sapiens_hsa040151.89301050
17Dorso-ventral axis formation_Homo sapiens_hsa043201.83182593
18Tight junction_Homo sapiens_hsa045301.79693084
19Amoebiasis_Homo sapiens_hsa051461.77991339
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.75704902
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75483943
22Tryptophan metabolism_Homo sapiens_hsa003801.63527599
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61998553
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59936346
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58799503
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58350359
27Axon guidance_Homo sapiens_hsa043601.58151497
28Cardiac muscle contraction_Homo sapiens_hsa042601.50995439
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44108462
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41011123
31Histidine metabolism_Homo sapiens_hsa003401.39996724
32HIF-1 signaling pathway_Homo sapiens_hsa040661.39551508
33Butanoate metabolism_Homo sapiens_hsa006501.39399549
34Viral myocarditis_Homo sapiens_hsa054161.38453313
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.37011408
36Selenocompound metabolism_Homo sapiens_hsa004501.36101795
37Ras signaling pathway_Homo sapiens_hsa040141.34034378
38Arachidonic acid metabolism_Homo sapiens_hsa005901.33527205
39Notch signaling pathway_Homo sapiens_hsa043301.32485747
40Toxoplasmosis_Homo sapiens_hsa051451.30860615
41Proteoglycans in cancer_Homo sapiens_hsa052051.26270079
42Sulfur metabolism_Homo sapiens_hsa009201.26162186
43Renal cell carcinoma_Homo sapiens_hsa052111.25855305
44ABC transporters_Homo sapiens_hsa020101.23870348
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.23028434
46TGF-beta signaling pathway_Homo sapiens_hsa043501.22147795
47Protein digestion and absorption_Homo sapiens_hsa049741.21103651
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18778765
49Complement and coagulation cascades_Homo sapiens_hsa046101.18097617
50Malaria_Homo sapiens_hsa051441.17410526
51Pathways in cancer_Homo sapiens_hsa052001.17034898
52Serotonergic synapse_Homo sapiens_hsa047261.16159130
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15523718
54Renin secretion_Homo sapiens_hsa049241.14087685
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12749525
56Arginine and proline metabolism_Homo sapiens_hsa003301.10313554
57Fatty acid degradation_Homo sapiens_hsa000711.09495781
58Insulin resistance_Homo sapiens_hsa049311.07079798
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05623054
60Protein export_Homo sapiens_hsa030601.03478193
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03183847
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02741161
63Platelet activation_Homo sapiens_hsa046111.02498787
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02159980
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99543627
66Melanogenesis_Homo sapiens_hsa049160.98226647
67Arginine biosynthesis_Homo sapiens_hsa002200.97669057
68Ovarian steroidogenesis_Homo sapiens_hsa049130.97445505
69Hippo signaling pathway_Homo sapiens_hsa043900.96919313
70Fatty acid elongation_Homo sapiens_hsa000620.95699142
71Bile secretion_Homo sapiens_hsa049760.94380719
72Morphine addiction_Homo sapiens_hsa050320.94086856
73PPAR signaling pathway_Homo sapiens_hsa033200.91186441
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90392436
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.89605776
76Taste transduction_Homo sapiens_hsa047420.88991351
77Basal cell carcinoma_Homo sapiens_hsa052170.88884394
78VEGF signaling pathway_Homo sapiens_hsa043700.88468666
79Chemical carcinogenesis_Homo sapiens_hsa052040.87550181
80Propanoate metabolism_Homo sapiens_hsa006400.87097391
81Nitrogen metabolism_Homo sapiens_hsa009100.84329916
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84191555
83Olfactory transduction_Homo sapiens_hsa047400.84130889
84beta-Alanine metabolism_Homo sapiens_hsa004100.83229472
85African trypanosomiasis_Homo sapiens_hsa051430.82597429
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82056832
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81973832
88Glutamatergic synapse_Homo sapiens_hsa047240.81129443
89Retinol metabolism_Homo sapiens_hsa008300.81082696
90Glycerolipid metabolism_Homo sapiens_hsa005610.80721086
91Caffeine metabolism_Homo sapiens_hsa002320.80683231
92cAMP signaling pathway_Homo sapiens_hsa040240.79853287
93Mineral absorption_Homo sapiens_hsa049780.77442146
94Pancreatic secretion_Homo sapiens_hsa049720.77100917
95Vitamin digestion and absorption_Homo sapiens_hsa049770.76937936
96Oxytocin signaling pathway_Homo sapiens_hsa049210.74188036
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73877249
98Estrogen signaling pathway_Homo sapiens_hsa049150.73547735
99Basal transcription factors_Homo sapiens_hsa030220.72764556
100Fatty acid metabolism_Homo sapiens_hsa012120.70654909
101Regulation of autophagy_Homo sapiens_hsa041400.70642426
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70160909
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69987205
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68219821
105Wnt signaling pathway_Homo sapiens_hsa043100.65892166
106MicroRNAs in cancer_Homo sapiens_hsa052060.64096031
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.63920988
108TNF signaling pathway_Homo sapiens_hsa046680.63267757
109Prostate cancer_Homo sapiens_hsa052150.62561120
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.62355809
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61233194
112Sphingolipid metabolism_Homo sapiens_hsa006000.60487542
113Peroxisome_Homo sapiens_hsa041460.60207141
114Phenylalanine metabolism_Homo sapiens_hsa003600.59657950
115GABAergic synapse_Homo sapiens_hsa047270.58006736
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57402553
117Glucagon signaling pathway_Homo sapiens_hsa049220.57303008
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56900943
119Staphylococcus aureus infection_Homo sapiens_hsa051500.56752215
120Gastric acid secretion_Homo sapiens_hsa049710.56366876
121Gap junction_Homo sapiens_hsa045400.54869887
122Insulin secretion_Homo sapiens_hsa049110.54768201
123Pyruvate metabolism_Homo sapiens_hsa006200.54000156
124Alzheimers disease_Homo sapiens_hsa050100.53541153
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52950635
126Salmonella infection_Homo sapiens_hsa051320.51935690
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51528006
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49434262
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49126804
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.47951399
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47888579
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47007223
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46187039
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.46114544
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.45429525
136Pertussis_Homo sapiens_hsa051330.45327731
137Lysine degradation_Homo sapiens_hsa003100.45001414
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44911790
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44788965
140Prion diseases_Homo sapiens_hsa050200.42857806
141Parkinsons disease_Homo sapiens_hsa050120.42218310
142Calcium signaling pathway_Homo sapiens_hsa040200.41912198
143Nicotine addiction_Homo sapiens_hsa050330.41647189
144Fat digestion and absorption_Homo sapiens_hsa049750.41289549
145AMPK signaling pathway_Homo sapiens_hsa041520.40688923
146Hepatitis C_Homo sapiens_hsa051600.39056662
147Hedgehog signaling pathway_Homo sapiens_hsa043400.38508550
148Salivary secretion_Homo sapiens_hsa049700.36346521
149Circadian entrainment_Homo sapiens_hsa047130.35695431
150Melanoma_Homo sapiens_hsa052180.35302920
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34354447
152Rheumatoid arthritis_Homo sapiens_hsa053230.33740325

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