SOX8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.98069433
2central nervous system myelination (GO:0022010)9.98069433
3dermatan sulfate biosynthetic process (GO:0030208)6.75787421
4dermatan sulfate metabolic process (GO:0030205)6.34852128
5myelination (GO:0042552)5.98881836
6ensheathment of neurons (GO:0007272)5.91444338
7axon ensheathment (GO:0008366)5.91444338
8chondroitin sulfate catabolic process (GO:0030207)5.56912969
9astrocyte differentiation (GO:0048708)5.50467794
10L-amino acid import (GO:0043092)5.34349667
11exploration behavior (GO:0035640)5.24974042
12cellular potassium ion homeostasis (GO:0030007)5.17644127
13fatty acid elongation (GO:0030497)5.09230344
14potassium ion import (GO:0010107)5.05527759
15sodium ion export (GO:0071436)4.91687905
16potassium ion homeostasis (GO:0055075)4.89157734
17neuron cell-cell adhesion (GO:0007158)4.73869444
18amino acid import (GO:0043090)4.64744580
19presynaptic membrane organization (GO:0097090)4.60814581
20presynaptic membrane assembly (GO:0097105)4.60707810
21negative regulation of neurotransmitter transport (GO:0051589)4.51630105
22long-chain fatty acid biosynthetic process (GO:0042759)4.40882308
23negative regulation of neurotransmitter secretion (GO:0046929)4.32172871
24* oligodendrocyte differentiation (GO:0048709)4.26585581
25negative regulation of protein localization to cell surface (GO:2000009)4.23605008
26neuronal action potential propagation (GO:0019227)4.08751961
27positive regulation of oligodendrocyte differentiation (GO:0048714)4.06286283
28myelin maintenance (GO:0043217)4.01709490
29astrocyte development (GO:0014002)3.99460860
30membrane assembly (GO:0071709)3.91798328
31cerebellar Purkinje cell layer development (GO:0021680)3.84773022
32regulation of synapse structural plasticity (GO:0051823)3.82309451
33myelination in peripheral nervous system (GO:0022011)3.80582163
34peripheral nervous system axon ensheathment (GO:0032292)3.80582163
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.73577923
36cerebral cortex radially oriented cell migration (GO:0021799)3.64835490
37adult walking behavior (GO:0007628)3.60545162
38neuron projection regeneration (GO:0031102)3.60364886
39positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.55833574
40negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54548823
41postsynaptic membrane organization (GO:0001941)3.52056710
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50042897
43locomotory exploration behavior (GO:0035641)3.49941387
44establishment of mitochondrion localization (GO:0051654)3.47573902
45neuromuscular process controlling balance (GO:0050885)3.47513010
46transmission of nerve impulse (GO:0019226)3.45742975
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39830586
48cellular sodium ion homeostasis (GO:0006883)3.38200934
49chondroitin sulfate biosynthetic process (GO:0030206)3.34546481
50glutamate secretion (GO:0014047)3.33866385
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.32411285
52regulation of neuron projection regeneration (GO:0070570)3.29602080
53regulation of axon regeneration (GO:0048679)3.29602080
54regulation of collateral sprouting (GO:0048670)3.29489525
55positive regulation of neurological system process (GO:0031646)3.28316595
56dendritic spine morphogenesis (GO:0060997)3.27189024
57long-term synaptic potentiation (GO:0060291)3.26374833
58regulation of neurotransmitter uptake (GO:0051580)3.25573053
59cell communication by electrical coupling (GO:0010644)3.24224035
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.23728755
61apical protein localization (GO:0045176)3.21232538
62cGMP-mediated signaling (GO:0019934)3.20516291
63glycine transport (GO:0015816)3.20328147
64asymmetric protein localization (GO:0008105)3.19000030
65L-glutamate transport (GO:0015813)3.18841629
66response to methylmercury (GO:0051597)3.17626628
67membrane hyperpolarization (GO:0060081)3.15319548
68substantia nigra development (GO:0021762)3.15172794
69glycerophospholipid catabolic process (GO:0046475)3.13406221
70neuronal ion channel clustering (GO:0045161)3.12355946
71neurotransmitter uptake (GO:0001504)3.12339362
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11128040
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10325963
74synaptic vesicle maturation (GO:0016188)3.10039479
75auditory behavior (GO:0031223)3.06062510
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04875000
77creatine metabolic process (GO:0006600)3.01762844
78regulation of synaptic vesicle transport (GO:1902803)3.00176622
79regulation of female receptivity (GO:0045924)3.00098292
80protein localization to synapse (GO:0035418)2.99500254
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97653647
82negative regulation of axonogenesis (GO:0050771)2.97650115
83cholesterol biosynthetic process (GO:0006695)2.95009427
84vocalization behavior (GO:0071625)2.94333911
85mechanosensory behavior (GO:0007638)2.94235982
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.93355651
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92244907
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91454391
89regulation of oligodendrocyte differentiation (GO:0048713)2.91202637
90glutamate receptor signaling pathway (GO:0007215)2.91033034
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90384354
92neurotransmitter secretion (GO:0007269)2.90160788
93one-carbon compound transport (GO:0019755)2.89130140
94cerebellar granule cell differentiation (GO:0021707)2.88151746
95gamma-aminobutyric acid transport (GO:0015812)2.86041824
96synaptic transmission, glutamatergic (GO:0035249)2.85899670
97neurotransmitter catabolic process (GO:0042135)2.85598705
98limb bud formation (GO:0060174)2.83591726
99negative regulation of axon extension (GO:0030517)2.81874377
100regulation of beta-amyloid formation (GO:1902003)2.81724969
101substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.81085462
102substrate-independent telencephalic tangential migration (GO:0021826)2.81085462
103membrane tubulation (GO:0097320)2.80055589
104regulation of synaptic plasticity (GO:0048167)2.79643932
105response to dietary excess (GO:0002021)2.79204626
106neuron recognition (GO:0008038)2.79182769
107cyclic nucleotide catabolic process (GO:0009214)2.78921214
108response to redox state (GO:0051775)2.78560270
109dendrite morphogenesis (GO:0048813)2.78156414
110import into cell (GO:0098657)2.76954642
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76178285
112regulation of respiratory gaseous exchange (GO:0043576)2.74944163
113neuron-neuron synaptic transmission (GO:0007270)2.73747263
114response to auditory stimulus (GO:0010996)2.72932534
115regulation of voltage-gated calcium channel activity (GO:1901385)2.71834558
116positive regulation of glial cell differentiation (GO:0045687)2.71317684
117regulation of synaptic vesicle exocytosis (GO:2000300)2.71208561
118glial cell development (GO:0021782)2.66863720
119regulation of neuronal synaptic plasticity (GO:0048168)2.66684712
120magnesium ion transport (GO:0015693)2.65120169
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65029954
122response to lipoprotein particle (GO:0055094)2.64925573
123adenosine receptor signaling pathway (GO:0001973)2.62740708
124protein palmitoylation (GO:0018345)2.61957550
125regulation of dendritic spine morphogenesis (GO:0061001)2.59506214
126adult locomotory behavior (GO:0008344)2.58480499
127synaptic vesicle exocytosis (GO:0016079)2.56928046
128positive regulation of synapse assembly (GO:0051965)2.56493716
129* glial cell differentiation (GO:0010001)2.56431834
130positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.56041267
131acidic amino acid transport (GO:0015800)2.55647249
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54930588
133sterol biosynthetic process (GO:0016126)2.54880095
134positive regulation of dendritic spine development (GO:0060999)2.54697021
135neurotransmitter-gated ion channel clustering (GO:0072578)2.53877436
136axon development (GO:0061564)2.52752968
137neuron remodeling (GO:0016322)2.52392975
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.51763007
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.51109498
140startle response (GO:0001964)2.50584243
141regulation of respiratory system process (GO:0044065)2.50013592
142regulation of glutamate receptor signaling pathway (GO:1900449)2.49854784
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49172426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15376353
2GBX2_23144817_ChIP-Seq_PC3_Human3.65645265
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07038327
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.95153438
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89107055
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87698441
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.71217012
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60637116
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60637116
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48714006
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48330709
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47767730
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44831202
14AR_21572438_ChIP-Seq_LNCaP_Human2.43647675
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.41916878
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41273799
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28960480
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23487802
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23392257
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22545707
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.20527193
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18949407
23DROSHA_22980978_ChIP-Seq_HELA_Human1.95089548
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90733825
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88635141
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.88013243
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86003327
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82368833
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76463690
30TAF15_26573619_Chip-Seq_HEK293_Human1.75379876
31REST_21632747_ChIP-Seq_MESCs_Mouse1.75104519
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.74485560
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.73797495
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.71546278
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70792832
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67656622
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67379825
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66428249
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61812910
40* KDM2B_26808549_Chip-Seq_K562_Human1.58142740
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55647013
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.54059582
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52842244
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48963915
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48832156
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47685535
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38451760
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37171889
49ER_23166858_ChIP-Seq_MCF-7_Human1.36850673
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.36713703
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.35869099
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35016875
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34265656
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32789700
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32221415
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30321251
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29582594
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28146683
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.27625158
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.26288363
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24796872
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23452712
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23189422
64P300_19829295_ChIP-Seq_ESCs_Human1.22646166
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.22349996
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22053504
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.19978302
68SMAD4_21799915_ChIP-Seq_A2780_Human1.18937103
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18696599
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17611689
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16528010
72LXR_22292898_ChIP-Seq_THP-1_Human1.15488067
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15339938
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14431141
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14091361
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13167979
77STAT3_23295773_ChIP-Seq_U87_Human1.12211005
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.12025311
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10988840
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08717693
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08520323
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07157621
83RNF2_27304074_Chip-Seq_NSC_Mouse1.06946341
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05834586
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05531394
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05329955
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05089715
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04183797
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03658098
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03327791
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02700583
92VDR_22108803_ChIP-Seq_LS180_Human1.02676488
93IGF1R_20145208_ChIP-Seq_DFB_Human1.00759618
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00376979
95FUS_26573619_Chip-Seq_HEK293_Human1.00322364
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99978023
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99849711
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.99789622
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99468606
100RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99128222
101TP53_23651856_ChIP-Seq_MEFs_Mouse0.98970212
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98805406
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98520194
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.98207288
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97713705
106TCF4_23295773_ChIP-Seq_U87_Human0.97330844
107CTCF_27219007_Chip-Seq_Bcells_Human0.97145421
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.97130736
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96881680
110GATA1_26923725_Chip-Seq_HPCs_Mouse0.96637029
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96382707
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.93837388
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.93594291
114CMYC_18555785_Chip-Seq_ESCs_Mouse0.93178462
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.92939394
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.92639891
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92512664
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92422354
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91635920
120* AR_19668381_ChIP-Seq_PC3_Human0.91519881
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89660871
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89187472
123* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88384363
124AR_25329375_ChIP-Seq_VCAP_Human0.88145799
125P300_18555785_Chip-Seq_ESCs_Mouse0.87509437
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87464312
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86914082
128* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86621905
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86588243
130ZNF274_21170338_ChIP-Seq_K562_Hela0.85676004
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.85253273
132* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85197187
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84563558
134* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84528278
135P53_22387025_ChIP-Seq_ESCs_Mouse0.84413433
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.84305809
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.83291585
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83284209
139MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82968130
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.82890501
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.82586884
142KLF4_19829295_ChIP-Seq_ESCs_Human0.81134888
143* SMC4_20622854_ChIP-Seq_HELA_Human0.79286780
144OCT4_19829295_ChIP-Seq_ESCs_Human0.79151988
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78973385
146NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78282467
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.76455501
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.75673104
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.75673104
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75373454
151MITF_21258399_ChIP-Seq_MELANOMA_Human0.74714209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.45508160
2MP0000920_abnormal_myelination4.19382224
3MP0004859_abnormal_synaptic_plasticity3.71575161
4MP0003136_yellow_coat_color3.17822451
5MP0004270_analgesia3.15395572
6MP0001486_abnormal_startle_reflex3.06232863
7MP0003635_abnormal_synaptic_transmissio2.79029560
8MP0002064_seizures2.75415006
9MP0002272_abnormal_nervous_system2.75193457
10MP0005171_absent_coat_pigmentation2.59243155
11MP0009745_abnormal_behavioral_response2.59180091
12MP0005423_abnormal_somatic_nervous2.58248485
13MP0003690_abnormal_glial_cell2.52831947
14MP0004885_abnormal_endolymph2.51290003
15MP0004142_abnormal_muscle_tone2.43235880
16MP0005167_abnormal_blood-brain_barrier2.39022393
17MP0005409_darkened_coat_color2.38947905
18MP0000778_abnormal_nervous_system2.38380780
19MP0003329_amyloid_beta_deposits2.37912634
20MP0009780_abnormal_chondrocyte_physiolo2.35660169
21MP0004742_abnormal_vestibular_system2.31048515
22MP0003634_abnormal_glial_cell2.28401936
23MP0001529_abnormal_vocalization2.22215694
24MP0009046_muscle_twitch2.18190758
25MP0001905_abnormal_dopamine_level2.15120800
26MP0002063_abnormal_learning/memory/cond2.12249190
27MP0002572_abnormal_emotion/affect_behav2.03785976
28MP0001485_abnormal_pinna_reflex2.01865419
29MP0002734_abnormal_mechanical_nocicepti1.92817036
30MP0001968_abnormal_touch/_nociception1.83825884
31MP0008569_lethality_at_weaning1.78089191
32MP0002067_abnormal_sensory_capabilities1.76044167
33MP0003183_abnormal_peptide_metabolism1.72435908
34MP0000955_abnormal_spinal_cord1.67422067
35MP0002822_catalepsy1.67400815
36MP0003950_abnormal_plasma_membrane1.61907547
37MP0002882_abnormal_neuron_morphology1.56102431
38MP0003632_abnormal_nervous_system1.54239738
39MP0002229_neurodegeneration1.53089944
40MP0002736_abnormal_nociception_after1.47970558
41MP0001970_abnormal_pain_threshold1.45240121
42MP0005410_abnormal_fertilization1.44416001
43MP0004381_abnormal_hair_follicle1.43613442
44MP0003879_abnormal_hair_cell1.43408014
45MP0001440_abnormal_grooming_behavior1.40811285
46MP0005646_abnormal_pituitary_gland1.40501228
47MP0005551_abnormal_eye_electrophysiolog1.39740460
48MP0002066_abnormal_motor_capabilities/c1.36519153
49MP0002557_abnormal_social/conspecific_i1.35877952
50MP0003631_nervous_system_phenotype1.32702064
51MP0002733_abnormal_thermal_nociception1.31108051
52MP0001963_abnormal_hearing_physiology1.26863815
53MP0004134_abnormal_chest_morphology1.25898871
54MP0001188_hyperpigmentation1.25862561
55MP0003633_abnormal_nervous_system1.25613206
56MP0001502_abnormal_circadian_rhythm1.25588446
57MP0004924_abnormal_behavior1.24798093
58MP0005386_behavior/neurological_phenoty1.24798093
59MP0000631_abnormal_neuroendocrine_gland1.23753365
60MP0004858_abnormal_nervous_system1.19634056
61MP0002752_abnormal_somatic_nervous1.19071255
62MP0002184_abnormal_innervation1.16951838
63MP0005645_abnormal_hypothalamus_physiol1.15248045
64MP0002909_abnormal_adrenal_gland1.14952738
65MP0005623_abnormal_meninges_morphology1.13794677
66MP0002152_abnormal_brain_morphology1.12373881
67MP0001501_abnormal_sleep_pattern1.12050594
68MP0010678_abnormal_skin_adnexa1.08909032
69MP0001177_atelectasis1.07632167
70MP0003172_abnormal_lysosome_physiology1.04952731
71MP0004130_abnormal_muscle_cell1.03158524
72MP0001299_abnormal_eye_distance/1.00467449
73MP0000604_amyloidosis1.00239876
74MP0004811_abnormal_neuron_physiology0.99252975
75MP0000462_abnormal_digestive_system0.98883721
76MP0001984_abnormal_olfaction0.96219055
77MP0000026_abnormal_inner_ear0.94631360
78MP0004043_abnormal_pH_regulation0.94365345
79MP0000383_abnormal_hair_follicle0.93856563
80MP0000566_synostosis0.92219081
81MP0002735_abnormal_chemical_nociception0.91769501
82MP0001986_abnormal_taste_sensitivity0.90629256
83MP0008260_abnormal_autophagy0.90181992
84MP0003787_abnormal_imprinting0.88987663
85MP0006072_abnormal_retinal_apoptosis0.88743723
86MP0002638_abnormal_pupillary_reflex0.88680812
87MP0009379_abnormal_foot_pigmentation0.87220202
88MP0003938_abnormal_ear_development0.85778632
89MP0005195_abnormal_posterior_eye0.85008456
90MP0005253_abnormal_eye_physiology0.83406919
91MP0004145_abnormal_muscle_electrophysio0.80358790
92MP0002102_abnormal_ear_morphology0.79915273
93MP0001346_abnormal_lacrimal_gland0.78826264
94MP0009250_abnormal_appendicular_skeleto0.77602523
95MP0000647_abnormal_sebaceous_gland0.73150424
96MP0006276_abnormal_autonomic_nervous0.71448868
97MP0003937_abnormal_limbs/digits/tail_de0.68088586
98MP0005670_abnormal_white_adipose0.67741401
99MP0001943_abnormal_respiration0.67574981
100MP0002090_abnormal_vision0.67477260
101MP0003861_abnormal_nervous_system0.66697388
102MP0002089_abnormal_postnatal_growth/wei0.65656268
103MP0002938_white_spotting0.64522396
104MP0003705_abnormal_hypodermis_morpholog0.64110000
105MP0000747_muscle_weakness0.64084554
106MP0009278_abnormal_bone_marrow0.63162004
107MP0005595_abnormal_vascular_smooth0.60757007
108MP0001664_abnormal_digestion0.60008405
109MP0002653_abnormal_ependyma_morphology0.59371431
110MP0000579_abnormal_nail_morphology0.59079748
111MP0001958_emphysema0.58050179
112MP0010769_abnormal_survival0.56772842
113MP0003075_altered_response_to0.56645239
114MP0003137_abnormal_impulse_conducting0.56429402
115MP0000762_abnormal_tongue_morphology0.56292364
116MP0002249_abnormal_larynx_morphology0.56155853
117MP0003119_abnormal_digestive_system0.55186351
118MP0002069_abnormal_eating/drinking_beha0.54731035
119MP0010770_preweaning_lethality0.52889167
120MP0002082_postnatal_lethality0.52889167
121MP0010768_mortality/aging0.52482431
122MP0005379_endocrine/exocrine_gland_phen0.51004714
123MP0005166_decreased_susceptibility_to0.50257792
124MP0008874_decreased_physiological_sensi0.50068183

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.44880298
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.44880298
3Neurofibrillary tangles (HP:0002185)5.19986741
4Myokymia (HP:0002411)5.15928812
5Peripheral hypomyelination (HP:0007182)4.96578260
6Obstructive sleep apnea (HP:0002870)4.32943168
7Abnormality of the corticospinal tract (HP:0002492)4.09331587
8Focal motor seizures (HP:0011153)3.88016944
9Sensory axonal neuropathy (HP:0003390)3.71919134
10Split foot (HP:0001839)3.68264645
11Anomalous pulmonary venous return (HP:0010772)3.67739896
12Abnormal auditory evoked potentials (HP:0006958)3.65415467
13Megalencephaly (HP:0001355)3.64428237
14Cerebral inclusion bodies (HP:0100314)3.58201971
15Supranuclear gaze palsy (HP:0000605)3.54808634
16Onion bulb formation (HP:0003383)3.52950392
17Action tremor (HP:0002345)3.44485261
18Dysmetria (HP:0001310)3.31261372
19Spastic gait (HP:0002064)3.29820639
20Parakeratosis (HP:0001036)3.28174982
21Alacrima (HP:0000522)3.27730421
22Ankle clonus (HP:0011448)3.26093065
23Abnormality of cochlea (HP:0000375)3.22999311
24Termporal pattern (HP:0011008)3.19323334
25Insidious onset (HP:0003587)3.19323334
26Abnormality of the pulmonary veins (HP:0011718)3.19088906
27Insomnia (HP:0100785)3.15281866
28Intention tremor (HP:0002080)3.06217736
29Retinal dysplasia (HP:0007973)3.01937293
30Cerebral hypomyelination (HP:0006808)3.01887280
31Abnormality of the 4th metacarpal (HP:0010012)2.96570407
32Hemiplegia (HP:0002301)2.86949358
33Absent septum pellucidum (HP:0001331)2.86490175
34Scanning speech (HP:0002168)2.85339601
35Morphological abnormality of the inner ear (HP:0011390)2.84570928
36Hyperacusis (HP:0010780)2.81923387
37Clumsiness (HP:0002312)2.79318535
38Truncus arteriosus (HP:0001660)2.77068135
39Aplasia involving bones of the extremities (HP:0009825)2.75727842
40Aplasia involving bones of the upper limbs (HP:0009823)2.75727842
41Aplasia of the phalanges of the hand (HP:0009802)2.75727842
42Overriding aorta (HP:0002623)2.72616092
43Ankyloglossia (HP:0010296)2.70566486
44Abnormality of the diencephalon (HP:0010662)2.69473676
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65552083
46Decreased lacrimation (HP:0000633)2.61479693
47Oligodactyly (HP:0012165)2.60734912
48Increased circulating renin level (HP:0000848)2.59686244
49Sleep apnea (HP:0010535)2.54062750
50Elfin facies (HP:0004428)2.52751347
51Synostosis of carpal bones (HP:0005048)2.52516192
52Focal seizures (HP:0007359)2.50494499
53Epileptic encephalopathy (HP:0200134)2.45410541
54Abnormality of the septum pellucidum (HP:0007375)2.44858074
55Generalized tonic-clonic seizures (HP:0002069)2.44582970
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42490629
57Hypoplastic pelvis (HP:0008839)2.41797929
58Septo-optic dysplasia (HP:0100842)2.38612180
59Premature skin wrinkling (HP:0100678)2.38112950
60Broad-based gait (HP:0002136)2.35347141
61Leukodystrophy (HP:0002415)2.31075414
62Dysdiadochokinesis (HP:0002075)2.29848861
63Slow saccadic eye movements (HP:0000514)2.28720620
64Akinesia (HP:0002304)2.28681196
65Segmental peripheral demyelination/remyelination (HP:0003481)2.28545695
66Hypoplasia of the iris (HP:0007676)2.27620409
67Gaze-evoked nystagmus (HP:0000640)2.26785939
68Hypomagnesemia (HP:0002917)2.24832579
69Mutism (HP:0002300)2.24828617
70Thickened helices (HP:0000391)2.23726345
71Lower limb muscle weakness (HP:0007340)2.23476541
72White forelock (HP:0002211)2.22743875
73Progressive cerebellar ataxia (HP:0002073)2.22636557
74Hyperventilation (HP:0002883)2.19108054
75Anxiety (HP:0000739)2.18662149
76Patchy hypopigmentation of hair (HP:0011365)2.16837177
77Abnormality of the ischium (HP:0003174)2.16736213
78Turricephaly (HP:0000262)2.14304566
79Fibular hypoplasia (HP:0003038)2.12921563
80Spastic paraparesis (HP:0002313)2.11685585
81Synostosis involving the elbow (HP:0003938)2.11426880
82Humeroradial synostosis (HP:0003041)2.11426880
83Urethral obstruction (HP:0000796)2.11066958
84Hyperparathyroidism (HP:0000843)2.09772292
85Shallow orbits (HP:0000586)2.09696161
86Renovascular hypertension (HP:0100817)2.07477400
87Metabolic alkalosis (HP:0200114)2.06548407
88Anteriorly placed anus (HP:0001545)2.05958789
89Coronal craniosynostosis (HP:0004440)2.05557010
90Bowel incontinence (HP:0002607)2.04352392
91Pheochromocytoma (HP:0002666)2.04218772
92Urinary urgency (HP:0000012)2.03980474
93Febrile seizures (HP:0002373)2.03438524
94Muscle fiber splitting (HP:0003555)2.02871123
95Hemiparesis (HP:0001269)2.02076109
96Hyporeflexia of lower limbs (HP:0002600)2.01652068
97CNS hypomyelination (HP:0003429)1.99968063
98Fetal akinesia sequence (HP:0001989)1.99609165
99Rigidity (HP:0002063)1.98412806
100Depression (HP:0000716)1.98241221
101Abnormality of magnesium homeostasis (HP:0004921)1.92852210
102Apathy (HP:0000741)1.92742334
103Torticollis (HP:0000473)1.92690870
104Generalized myoclonic seizures (HP:0002123)1.91729093
105Blue irides (HP:0000635)1.90016042
106Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89201023
107Oligodactyly (hands) (HP:0001180)1.88482838
108Renal duplication (HP:0000075)1.87567640
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.86937541
110Absent/shortened dynein arms (HP:0200106)1.86937541
111Postural instability (HP:0002172)1.86702809
112Neuronal loss in central nervous system (HP:0002529)1.86211681
113Foot dorsiflexor weakness (HP:0009027)1.86133406
114Absent speech (HP:0001344)1.85779717
115Partial duplication of thumb phalanx (HP:0009944)1.85691635
116Abnormal large intestine physiology (HP:0012700)1.83161636
117Double outlet right ventricle (HP:0001719)1.82372043
118Congenital malformation of the right heart (HP:0011723)1.82372043
119Limb dystonia (HP:0002451)1.81989454
120Vertebral clefting (HP:0008428)1.81578220
121Split hand (HP:0001171)1.79636217
122Rapidly progressive (HP:0003678)1.79000137
123Pointed chin (HP:0000307)1.78422256
124Relative macrocephaly (HP:0004482)1.78336952
125Partial agenesis of the corpus callosum (HP:0001338)1.78250062
126Abnormality of the periventricular white matter (HP:0002518)1.78197055
127Laryngomalacia (HP:0001601)1.76924367
128Stereotypic behavior (HP:0000733)1.76183333
129Diplopia (HP:0000651)1.75857122
130Abnormality of binocular vision (HP:0011514)1.75857122
131Megalocornea (HP:0000485)1.74966771
132Flat cornea (HP:0007720)1.74628028
133Abnormality of the foot musculature (HP:0001436)1.74237603
134Neoplasm of the heart (HP:0100544)1.73958048
135Rib fusion (HP:0000902)1.73954788
136Short palpebral fissure (HP:0012745)1.73463656
137Abnormality of the middle phalanges of the toes (HP:0010183)1.73012625
138Decreased motor nerve conduction velocity (HP:0003431)1.72718628
139Neuroendocrine neoplasm (HP:0100634)1.70194348
140Urinary bladder sphincter dysfunction (HP:0002839)1.69763093
141Atonic seizures (HP:0010819)1.69669407
142Clonus (HP:0002169)1.68743441
143Cupped ear (HP:0000378)1.66991156
144Optic nerve hypoplasia (HP:0000609)1.66411695
145Chin dimple (HP:0010751)1.65951636
146Hypokalemic alkalosis (HP:0001949)1.65806253
147Spastic tetraparesis (HP:0001285)1.65794507
148Progressive inability to walk (HP:0002505)1.65591590
149Congenital ichthyosiform erythroderma (HP:0007431)1.64576484
150Truncal ataxia (HP:0002078)1.64192716
151Abnormal eating behavior (HP:0100738)1.63949592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.55056401
2TNIK3.80987351
3CASK3.50802823
4OXSR13.33147097
5EPHA42.70941255
6CDK192.44219069
7EPHB12.38133863
8PRPF4B2.29983873
9DDR22.25650873
10MAPKAPK52.14945419
11TYRO32.10570320
12PKN12.05721341
13UHMK11.88765196
14MUSK1.86617349
15NEK61.77791648
16NTRK11.77564366
17MARK11.74525818
18PDGFRA1.68817827
19RIPK11.68286575
20NTRK21.67244766
21LIMK11.64772201
22PBK1.63861011
23PAK61.62457844
24NTRK31.62314386
25BCR1.61462575
26WNK41.54535775
27SGK4941.47853675
28SGK2231.47853675
29FES1.45901864
30IRAK21.44083945
31SGK21.38781058
32MET1.37463396
33CAMK2B1.35346965
34CSNK1G31.35001049
35WNK11.32750024
36CSNK1A1L1.31470109
37FGR1.30882327
38MAPK131.24699191
39ROCK21.23250975
40CAMKK11.21638085
41CLK11.19839102
42ICK1.17556015
43CDK51.15614502
44CSNK1G11.14297564
45PRKD31.13303503
46CSNK1G21.12132112
47PHKG21.11716918
48PHKG11.11716918
49MAP2K71.10462664
50FGFR21.09475874
51TESK21.05600218
52SGK31.02557439
53CAMK2D1.01011899
54SIK21.00124957
55PNCK0.98602030
56CAMK2A0.96796315
57MAPK100.93727465
58CDK140.89610428
59MAPK120.89334107
60PINK10.89002081
61CAMK2G0.87120809
62ERBB40.85228027
63IRAK10.79585647
64CDK150.79274162
65DYRK20.79271975
66MKNK20.78309131
67MKNK10.78264544
68KSR20.75882968
69PAK30.74406419
70ALK0.74313661
71MAP3K130.74277726
72CDK180.74191022
73MAP3K40.73218283
74CDK11A0.72821939
75TRIB30.72384922
76MARK20.70933724
77PRKCQ0.70285480
78PRKCE0.67072124
79MINK10.65199397
80LMTK20.63831682
81STK110.62157860
82ERBB20.60400486
83PRKCH0.59751436
84STK38L0.59249629
85ARAF0.56971944
86PRKD10.56095259
87PTK20.55117688
88BMPR20.54728892
89FYN0.53802432
90MAP3K90.53219583
91PRKD20.52034342
92STK380.51550277
93DMPK0.48611727
94PRKCZ0.47876914
95BMX0.46356448
96PIK3CA0.46295030
97PDPK10.46039336
98MAP2K10.45310338
99RPS6KA30.44903560
100RPS6KB10.44754221
101RIPK40.44670293
102PRKG10.44395064
103CAMK10.42940782
104DYRK1A0.42219018
105TNK20.42134793
106PDGFRB0.41554842
107CSNK1A10.41470568
108CSNK1D0.41318704
109PRKCG0.40324481
110LATS20.40208346
111MAP3K70.40205060
112CAMK40.39869658
113KSR10.38530816
114DAPK20.37651041
115CAMK1G0.37234551
116MAP3K20.36642277
117RAF10.36606397
118MOS0.36013811
119ROCK10.35865004
120RET0.35171627
121PRKDC0.34269233
122PRKACA0.34080998
123FGFR40.33329128
124SGK10.33002783
125HIPK20.32443601
126PRKACB0.32307405
127BMPR1B0.31484826
128PLK20.30618773
129ABL20.29999819
130CDK30.29182688
131SRC0.28601513
132GSK3B0.26327086
133CAMK1D0.25117326

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.63019585
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.05641580
3Steroid biosynthesis_Homo sapiens_hsa001003.02799201
4Fatty acid elongation_Homo sapiens_hsa000622.93435923
5Nitrogen metabolism_Homo sapiens_hsa009102.74341848
6Ether lipid metabolism_Homo sapiens_hsa005652.43580506
7Glutamatergic synapse_Homo sapiens_hsa047242.36288440
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24274214
9GABAergic synapse_Homo sapiens_hsa047272.23378854
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18058665
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13456753
12Nicotine addiction_Homo sapiens_hsa050332.10825334
13Morphine addiction_Homo sapiens_hsa050322.06020178
14Axon guidance_Homo sapiens_hsa043601.87078067
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87024548
16Circadian entrainment_Homo sapiens_hsa047131.84515559
17Long-term depression_Homo sapiens_hsa047301.67631070
18Serotonergic synapse_Homo sapiens_hsa047261.62236276
19Olfactory transduction_Homo sapiens_hsa047401.62208973
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52632982
21Cholinergic synapse_Homo sapiens_hsa047251.51491815
22Notch signaling pathway_Homo sapiens_hsa043301.51454488
23Bile secretion_Homo sapiens_hsa049761.50740743
24Cocaine addiction_Homo sapiens_hsa050301.49343839
25Salivary secretion_Homo sapiens_hsa049701.45906982
26Sphingolipid metabolism_Homo sapiens_hsa006001.39756961
27Synaptic vesicle cycle_Homo sapiens_hsa047211.39660810
28Dopaminergic synapse_Homo sapiens_hsa047281.38176871
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35766156
30Vitamin B6 metabolism_Homo sapiens_hsa007501.32396854
31Gastric acid secretion_Homo sapiens_hsa049711.30555362
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28524149
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25855536
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18498017
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.18114066
36Amphetamine addiction_Homo sapiens_hsa050311.17383209
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.13573632
38Endometrial cancer_Homo sapiens_hsa052131.12549554
39Long-term potentiation_Homo sapiens_hsa047201.12446746
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12318820
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12083906
42Dorso-ventral axis formation_Homo sapiens_hsa043201.11624017
43Gap junction_Homo sapiens_hsa045401.07875833
44Renin secretion_Homo sapiens_hsa049241.07000317
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06614909
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.04707523
47Phototransduction_Homo sapiens_hsa047441.04321727
48Oxidative phosphorylation_Homo sapiens_hsa001901.03061646
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02577780
50beta-Alanine metabolism_Homo sapiens_hsa004101.02277324
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99403813
52cAMP signaling pathway_Homo sapiens_hsa040240.97620525
53Insulin secretion_Homo sapiens_hsa049110.96460278
54Thyroid hormone synthesis_Homo sapiens_hsa049180.94925711
55Renal cell carcinoma_Homo sapiens_hsa052110.94128461
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93829580
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93670373
58Taste transduction_Homo sapiens_hsa047420.92459156
59Linoleic acid metabolism_Homo sapiens_hsa005910.91177045
60ErbB signaling pathway_Homo sapiens_hsa040120.91170774
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.90878334
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90499970
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89941654
64VEGF signaling pathway_Homo sapiens_hsa043700.89035602
65Calcium signaling pathway_Homo sapiens_hsa040200.88386495
66Melanogenesis_Homo sapiens_hsa049160.88263296
67Sulfur metabolism_Homo sapiens_hsa009200.87520367
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86908392
69Ras signaling pathway_Homo sapiens_hsa040140.86843998
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85720760
71Hedgehog signaling pathway_Homo sapiens_hsa043400.84377010
72Fatty acid biosynthesis_Homo sapiens_hsa000610.84369896
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83008925
74Parkinsons disease_Homo sapiens_hsa050120.80913032
75Oxytocin signaling pathway_Homo sapiens_hsa049210.80774946
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80442408
77Alzheimers disease_Homo sapiens_hsa050100.79596712
78Ovarian steroidogenesis_Homo sapiens_hsa049130.79289417
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79058092
80Tight junction_Homo sapiens_hsa045300.78841248
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77553992
82Pancreatic secretion_Homo sapiens_hsa049720.77344676
83Cardiac muscle contraction_Homo sapiens_hsa042600.75072007
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75051747
85Collecting duct acid secretion_Homo sapiens_hsa049660.74810729
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74747526
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74476363
88Chronic myeloid leukemia_Homo sapiens_hsa052200.72253966
89Butanoate metabolism_Homo sapiens_hsa006500.72223746
90Choline metabolism in cancer_Homo sapiens_hsa052310.71401704
91Colorectal cancer_Homo sapiens_hsa052100.69636271
92GnRH signaling pathway_Homo sapiens_hsa049120.67637278
93Vibrio cholerae infection_Homo sapiens_hsa051100.67592536
94Wnt signaling pathway_Homo sapiens_hsa043100.64353082
95Endocytosis_Homo sapiens_hsa041440.64080438
96Non-small cell lung cancer_Homo sapiens_hsa052230.64043829
97Inositol phosphate metabolism_Homo sapiens_hsa005620.63142804
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62962039
99Basal cell carcinoma_Homo sapiens_hsa052170.62341700
100Protein export_Homo sapiens_hsa030600.60864943
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60758410
102mTOR signaling pathway_Homo sapiens_hsa041500.60414582
103Hippo signaling pathway_Homo sapiens_hsa043900.60305605
104Dilated cardiomyopathy_Homo sapiens_hsa054140.60070048
105AMPK signaling pathway_Homo sapiens_hsa041520.58699613
106Alcoholism_Homo sapiens_hsa050340.56901948
107Circadian rhythm_Homo sapiens_hsa047100.56119568
108Fatty acid metabolism_Homo sapiens_hsa012120.55595706
109Arginine and proline metabolism_Homo sapiens_hsa003300.54576584
110PPAR signaling pathway_Homo sapiens_hsa033200.54163793
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51240832
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50761381
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50169826
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.49603480
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49136425
116Glioma_Homo sapiens_hsa052140.48481759
117Histidine metabolism_Homo sapiens_hsa003400.46812789
118MicroRNAs in cancer_Homo sapiens_hsa052060.45371565
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45161619
120Rap1 signaling pathway_Homo sapiens_hsa040150.44237162
121MAPK signaling pathway_Homo sapiens_hsa040100.44064667
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43633305
123Estrogen signaling pathway_Homo sapiens_hsa049150.42646541
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42442844
125Prolactin signaling pathway_Homo sapiens_hsa049170.42369882
126Chemokine signaling pathway_Homo sapiens_hsa040620.42145730
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41950486
128Type II diabetes mellitus_Homo sapiens_hsa049300.41919421
129Prion diseases_Homo sapiens_hsa050200.37794976
130Autoimmune thyroid disease_Homo sapiens_hsa053200.37567207
131Rheumatoid arthritis_Homo sapiens_hsa053230.34627070

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