SOX9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte development (GO:0002063)5.86519633
2axon ensheathment in central nervous system (GO:0032291)5.23857174
3central nervous system myelination (GO:0022010)5.23857174
4negative regulation of astrocyte differentiation (GO:0048712)5.19686141
5presynaptic membrane assembly (GO:0097105)4.91156148
6* cell aggregation (GO:0098743)4.90981545
7* cartilage condensation (GO:0001502)4.90981545
8negative regulation of oligodendrocyte differentiation (GO:0048715)4.88910954
9cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.84899732
10* limb bud formation (GO:0060174)4.71180399
11lateral sprouting from an epithelium (GO:0060601)4.67323813
12G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.43619010
13regulation of astrocyte differentiation (GO:0048710)4.26688586
14epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.25046402
15postsynaptic membrane organization (GO:0001941)4.14316640
16* notochord development (GO:0030903)4.07407868
17cilium movement (GO:0003341)4.02576631
18radial glial cell differentiation (GO:0060019)4.00897432
19presynaptic membrane organization (GO:0097090)4.00637415
20atrioventricular valve morphogenesis (GO:0003181)3.99705921
21pattern specification involved in kidney development (GO:0061004)3.77904802
22* endocardial cushion morphogenesis (GO:0003203)3.76988304
23embryonic skeletal joint morphogenesis (GO:0060272)3.73921149
24axoneme assembly (GO:0035082)3.73629215
25positive regulation of astrocyte differentiation (GO:0048711)3.72297184
26lung epithelium development (GO:0060428)3.70926050
27keratan sulfate catabolic process (GO:0042340)3.70606862
28negative regulation of glial cell differentiation (GO:0045686)3.69987240
29endothelial cell morphogenesis (GO:0001886)3.67700553
30embryonic retina morphogenesis in camera-type eye (GO:0060059)3.67084186
31neuronal stem cell maintenance (GO:0097150)3.62033480
32cellular response to BMP stimulus (GO:0071773)3.59409917
33response to BMP (GO:0071772)3.59409917
34collagen fibril organization (GO:0030199)3.55820634
35* chondrocyte differentiation (GO:0002062)3.51563658
36cerebral cortex radially oriented cell migration (GO:0021799)3.51019842
37somite development (GO:0061053)3.45212584
38chondrocyte proliferation (GO:0035988)3.45112624
39SMAD protein signal transduction (GO:0060395)3.45080310
40* cartilage development (GO:0051216)3.44018487
41* mesenchyme morphogenesis (GO:0072132)3.43511723
42cardiac epithelial to mesenchymal transition (GO:0060317)3.43298395
43astrocyte differentiation (GO:0048708)3.41283112
44cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.38006582
45negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.35984320
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31845675
47lens fiber cell development (GO:0070307)3.30873164
48positive regulation of neuroblast proliferation (GO:0002052)3.30466002
49* positive regulation of extracellular matrix organization (GO:1903055)3.28805344
50cell proliferation involved in metanephros development (GO:0072203)3.17488649
51regulation of development, heterochronic (GO:0040034)3.16934970
52regulation of timing of cell differentiation (GO:0048505)3.14594219
53tongue development (GO:0043586)3.14161084
54telencephalon development (GO:0021537)3.14089564
55chondroitin sulfate biosynthetic process (GO:0030206)3.14046628
56* heart valve morphogenesis (GO:0003179)3.12170038
57response to gravity (GO:0009629)3.09114481
58negative regulation of keratinocyte proliferation (GO:0010839)3.04576565
59desmosome organization (GO:0002934)3.03581692
60embryonic foregut morphogenesis (GO:0048617)3.02847985
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02720639
62* positive regulation of cartilage development (GO:0061036)3.00959560
63regulation of extracellular matrix disassembly (GO:0010715)2.98403768
64negative regulation of smoothened signaling pathway (GO:0045879)2.97858665
65regulation of somitogenesis (GO:0014807)2.95054403
66* oligodendrocyte differentiation (GO:0048709)2.92384070
67middle ear morphogenesis (GO:0042474)2.90254084
68epithelial cilium movement (GO:0003351)2.89162509
69inner ear receptor cell differentiation (GO:0060113)2.88946767
70proteoglycan metabolic process (GO:0006029)2.88781348
71short-term memory (GO:0007614)2.88450222
72negative regulation of catenin import into nucleus (GO:0035414)2.88399003
73neuron cell-cell adhesion (GO:0007158)2.87635292
74digestive tract morphogenesis (GO:0048546)2.86948304
75cell surface receptor signaling pathway involved in heart development (GO:0061311)2.86886929
76* glial cell differentiation (GO:0010001)2.86643602
77* regulation of extracellular matrix organization (GO:1903053)2.86453164
78ovulation cycle (GO:0042698)2.82283842
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82185084
80* heart valve formation (GO:0003188)2.80973156
81embryonic camera-type eye development (GO:0031076)2.80684820
82renal system development (GO:0072001)2.80355385
83forebrain neuron differentiation (GO:0021879)2.77971272
84layer formation in cerebral cortex (GO:0021819)2.77536235
85glomerulus development (GO:0032835)2.76642882
86mesenchymal cell proliferation (GO:0010463)2.76345371
87lens morphogenesis in camera-type eye (GO:0002089)2.76092846
88skin morphogenesis (GO:0043589)2.74349138
89vocalization behavior (GO:0071625)2.73784196
90kidney morphogenesis (GO:0060993)2.73214071
91dermatan sulfate biosynthetic process (GO:0030208)2.72790349
92axonal fasciculation (GO:0007413)2.70874271
93auditory receptor cell differentiation (GO:0042491)2.70860093
94embryonic viscerocranium morphogenesis (GO:0048703)2.69477526
95regulation of non-canonical Wnt signaling pathway (GO:2000050)2.68640244
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68560243
97* positive regulation of chondrocyte differentiation (GO:0032332)2.68304158
98* positive regulation of stem cell differentiation (GO:2000738)2.67829014
99axonemal dynein complex assembly (GO:0070286)2.66928635
100cranial nerve development (GO:0021545)2.66765909
101negative regulation of gliogenesis (GO:0014014)2.65765493
102nephron epithelium morphogenesis (GO:0072088)2.65460400
103nephron tubule morphogenesis (GO:0072078)2.65460400
104left/right axis specification (GO:0070986)2.64690021
105neuron fate determination (GO:0048664)2.63835016
106non-canonical Wnt signaling pathway (GO:0035567)2.63595565
107dermatan sulfate metabolic process (GO:0030205)2.62315684
108paraxial mesoderm development (GO:0048339)2.62175784
109cell proliferation involved in kidney development (GO:0072111)2.62134640
110* skeletal system development (GO:0001501)2.60724990
111chondroitin sulfate catabolic process (GO:0030207)2.59935115
112Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59705747
113outer ear morphogenesis (GO:0042473)2.59431438
114response to follicle-stimulating hormone (GO:0032354)2.58925904
115* regulation of cartilage development (GO:0061035)2.58867316
116* regulation of chondrocyte differentiation (GO:0032330)2.58264153
117somatic stem cell division (GO:0048103)2.58240429
118cellular response to cholesterol (GO:0071397)2.57323837
119mechanoreceptor differentiation (GO:0042490)2.57191107
120one-carbon compound transport (GO:0019755)2.56320769
121renal tubule morphogenesis (GO:0061333)2.56104976
122apical protein localization (GO:0045176)2.56104616
123hemidesmosome assembly (GO:0031581)2.56023628
124neurotransmitter-gated ion channel clustering (GO:0072578)2.54692392
125positive regulation of osteoblast proliferation (GO:0033690)2.54182503
126regulation of transforming growth factor beta2 production (GO:0032909)2.54033263
127Notch signaling involved in heart development (GO:0061314)2.53904256
128* negative regulation of chondrocyte differentiation (GO:0032331)2.52179993
129membrane assembly (GO:0071709)2.51712561
130positive regulation of vascular permeability (GO:0043117)2.50479058
131regulation of establishment of planar polarity (GO:0090175)2.49753211
132* cell-cell signaling involved in cell fate commitment (GO:0045168)2.49631295
133limb development (GO:0060173)2.49596526
134appendage development (GO:0048736)2.49596526
135cellular response to sterol (GO:0036315)2.48510159
136cell proliferation in forebrain (GO:0021846)2.47701386
137axis elongation (GO:0003401)2.46507724
138regulation of oligodendrocyte differentiation (GO:0048713)2.45524015
139neuron recognition (GO:0008038)2.44755806
140cochlea development (GO:0090102)2.44753680
141asymmetric protein localization (GO:0008105)2.44282050
142cellular potassium ion homeostasis (GO:0030007)2.43785608
143cerebral cortex cell migration (GO:0021795)2.43066521
144auditory behavior (GO:0031223)2.43026442
145regulation of inclusion body assembly (GO:0090083)2.40538228
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.39488954
147ectodermal placode formation (GO:0060788)2.38441638
148cellular sodium ion homeostasis (GO:0006883)2.35866405
149cell morphogenesis involved in neuron differentiation (GO:0048667)2.34581702
150positive regulation of neural precursor cell proliferation (GO:2000179)2.34235091
151regulation of axon guidance (GO:1902667)2.33522453
152C4-dicarboxylate transport (GO:0015740)2.31325316
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31242564
154branching involved in salivary gland morphogenesis (GO:0060445)2.30907060
155regulation of smoothened signaling pathway (GO:0008589)2.30823102
156* negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.30763948
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.30566598
158cellular response to gonadotropin stimulus (GO:0071371)2.29834454
159regulation of neuroblast proliferation (GO:1902692)2.29213027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.00353733
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.11940734
3* EED_16625203_ChIP-ChIP_MESCs_Mouse2.84276319
4* AR_21572438_ChIP-Seq_LNCaP_Human2.83129711
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71922451
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.64819877
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57821611
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51799398
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48361034
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46050145
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44300593
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44300593
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40251131
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36591606
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26308455
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.24426358
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22269473
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.19226819
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13066290
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11077341
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.08818815
22TP53_18474530_ChIP-ChIP_U2OS_Human1.92509169
23* TP53_20018659_ChIP-ChIP_R1E_Mouse1.85897245
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83784643
25* EZH2_27294783_Chip-Seq_ESCs_Mouse1.83105518
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77337283
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75138326
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72422368
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66117873
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65969934
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64485370
32EZH2_22144423_ChIP-Seq_EOC_Human1.61726885
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.58500774
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58182946
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.57812701
36* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.57652852
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55523639
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.50492375
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46882906
40* CJUN_26792858_Chip-Seq_BT549_Human1.45551498
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43752687
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43536518
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.42012158
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41210696
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40687666
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39035295
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36526958
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35739256
49* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34972972
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.34219739
51GBX2_23144817_ChIP-Seq_PC3_Human1.33451760
52* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32376617
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31841506
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.30530035
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30053168
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29148743
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.27630411
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27335291
59P300_19829295_ChIP-Seq_ESCs_Human1.25676634
60* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25489807
61CLOCK_20551151_ChIP-Seq_293T_Human1.25337711
62RNF2_27304074_Chip-Seq_NSC_Mouse1.24223908
63* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23893073
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21615957
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20532768
66* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20430995
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19726301
68* RXR_22108803_ChIP-Seq_LS180_Human1.19584789
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.19102565
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18983165
71* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18922251
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.18031787
73* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16526349
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15467357
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15396302
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15379823
77TP53_16413492_ChIP-PET_HCT116_Human1.15216590
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15210259
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.14065269
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13291209
81* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11610446
82* ESR2_21235772_ChIP-Seq_MCF-7_Human1.10604198
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10262360
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.09660894
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.09626050
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.07626356
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07469048
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07099483
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07099483
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06618613
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.06522058
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06322737
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06271385
94AR_21909140_ChIP-Seq_LNCAP_Human1.05220995
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05150431
96BCAT_22108803_ChIP-Seq_LS180_Human1.04855147
97AHR_22903824_ChIP-Seq_MCF-7_Human1.04478705
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04342951
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03563995
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02852225
101SOX2_20726797_ChIP-Seq_SW620_Human1.02818675
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02335794
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02231766
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01369074
105* SMAD4_21799915_ChIP-Seq_A2780_Human1.01264754
106* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01074939
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00301286
108* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99059961
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98861866
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98648834
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98431387
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98119990
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97710289
114* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97286182
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96138015
116* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95267077
117* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95267077
118* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95136182
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.94892685
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93463603
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93389162
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93073895
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91962006
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91892342
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91140189
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89191507
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88344201
128TP63_23658742_ChIP-Seq_EP156T_Human0.86979932
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.85194999
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84977174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.71173266
2MP0010030_abnormal_orbit_morphology3.97692609
3MP0004134_abnormal_chest_morphology3.35738534
4* MP0002282_abnormal_trachea_morphology3.31505366
5MP0003136_yellow_coat_color3.29606751
6* MP0009250_abnormal_appendicular_skeleto2.94099206
7MP0005503_abnormal_tendon_morphology2.70046654
8* MP0000049_abnormal_middle_ear2.59943874
9MP0009384_cardiac_valve_regurgitation2.54661116
10* MP0000762_abnormal_tongue_morphology2.50499005
11MP0009780_abnormal_chondrocyte_physiolo2.47154600
12* MP0000163_abnormal_cartilage_morphology2.44551762
13* MP0002249_abnormal_larynx_morphology2.38993615
14MP0003122_maternal_imprinting2.36397090
15MP0004885_abnormal_endolymph2.27808219
16MP0005508_abnormal_skeleton_morphology2.20685424
17* MP0003755_abnormal_palate_morphology2.12359911
18MP0003941_abnormal_skin_development2.11297175
19MP0005275_abnormal_skin_tensile2.06925433
20MP0000537_abnormal_urethra_morphology2.01455629
21MP0002933_joint_inflammation1.97895420
22MP0002653_abnormal_ependyma_morphology1.91842935
23MP0000647_abnormal_sebaceous_gland1.89278751
24MP0001299_abnormal_eye_distance/1.86455135
25MP0008004_abnormal_stomach_pH1.81879508
26* MP0002116_abnormal_craniofacial_bone1.80456826
27* MP0002115_abnormal_skeleton_extremities1.80171913
28MP0001346_abnormal_lacrimal_gland1.79157099
29MP0002254_reproductive_system_inflammat1.76343878
30MP0004381_abnormal_hair_follicle1.72504324
31MP0002098_abnormal_vibrissa_morphology1.71188659
32* MP0003937_abnormal_limbs/digits/tail_de1.70765957
33MP0002089_abnormal_postnatal_growth/wei1.64777573
34MP0009053_abnormal_anal_canal1.63860026
35MP0001485_abnormal_pinna_reflex1.62721268
36MP0004272_abnormal_basement_membrane1.62609750
37MP0002102_abnormal_ear_morphology1.57059905
38MP0000579_abnormal_nail_morphology1.56128624
39* MP0002109_abnormal_limb_morphology1.55883494
40* MP0002233_abnormal_nose_morphology1.54637227
41MP0003385_abnormal_body_wall1.53300911
42MP0000383_abnormal_hair_follicle1.52930404
43* MP0002113_abnormal_skeleton_development1.49055091
44MP0003942_abnormal_urinary_system1.46690384
45MP0002928_abnormal_bile_duct1.45842904
46MP0002092_abnormal_eye_morphology1.44670973
47* MP0000428_abnormal_craniofacial_morphol1.42663642
48MP0000026_abnormal_inner_ear1.42650356
49MP0004270_analgesia1.40707609
50MP0005646_abnormal_pituitary_gland1.40599723
51* MP0000432_abnormal_head_morphology1.38604430
52MP0001286_abnormal_eye_development1.34340499
53MP0003938_abnormal_ear_development1.33878327
54MP0002932_abnormal_joint_morphology1.33699619
55MP0002938_white_spotting1.32528503
56MP0005257_abnormal_intraocular_pressure1.32327123
57MP0005390_skeleton_phenotype1.31563110
58MP0003123_paternal_imprinting1.30020562
59MP0010678_abnormal_skin_adnexa1.29343664
60* MP0002896_abnormal_bone_mineralization1.29313567
61MP0005623_abnormal_meninges_morphology1.25735795
62MP0002234_abnormal_pharynx_morphology1.25687643
63MP0005248_abnormal_Harderian_gland1.25124275
64* MP0001270_distended_abdomen1.24546421
65MP0008789_abnormal_olfactory_epithelium1.19682597
66MP0003279_aneurysm1.18722745
67MP0000467_abnormal_esophagus_morphology1.18578805
68MP0002108_abnormal_muscle_morphology1.18558069
69MP0001958_emphysema1.17155712
70* MP0003935_abnormal_craniofacial_develop1.16742780
71MP0003315_abnormal_perineum_morphology1.16711784
72MP0000778_abnormal_nervous_system1.16291851
73* MP0003861_abnormal_nervous_system1.16250281
74MP0003121_genomic_imprinting1.16076875
75MP0002796_impaired_skin_barrier1.15884724
76MP0001293_anophthalmia1.14695703
77MP0003943_abnormal_hepatobiliary_system1.11914407
78MP0004859_abnormal_synaptic_plasticity1.11677636
79MP0001340_abnormal_eyelid_morphology1.10175191
80MP0001486_abnormal_startle_reflex1.09981591
81MP0000955_abnormal_spinal_cord1.04015535
82MP0001502_abnormal_circadian_rhythm1.03233198
83MP0005391_vision/eye_phenotype1.02672656
84MP0000631_abnormal_neuroendocrine_gland1.02441744
85MP0009379_abnormal_foot_pigmentation1.01761038
86* MP0000534_abnormal_ureter_morphology1.00581397
87* MP0000377_abnormal_hair_follicle1.00472693
88MP0002060_abnormal_skin_morphology1.00205544
89MP0000462_abnormal_digestive_system1.00098925
90MP0002557_abnormal_social/conspecific_i0.99851196
91MP0003634_abnormal_glial_cell0.99216222
92MP0002152_abnormal_brain_morphology0.99032366
93MP0004742_abnormal_vestibular_system0.96417730
94MP0003878_abnormal_ear_physiology0.95712587
95MP0005377_hearing/vestibular/ear_phenot0.95712587
96* MP0002111_abnormal_tail_morphology0.92923525
97MP0010234_abnormal_vibrissa_follicle0.90846331
98MP0003115_abnormal_respiratory_system0.88974142
99* MP0002114_abnormal_axial_skeleton0.87669273
100MP0000678_abnormal_parathyroid_gland0.87302275
101MP0001984_abnormal_olfaction0.86527667
102MP0005409_darkened_coat_color0.85461460
103MP0002177_abnormal_outer_ear0.85438154
104MP0005195_abnormal_posterior_eye0.83312390
105MP0001529_abnormal_vocalization0.83253276
106MP0004264_abnormal_extraembryonic_tissu0.83167690
107MP0008438_abnormal_cutaneous_collagen0.83001674
108MP0004133_heterotaxia0.82880623
109MP0005394_taste/olfaction_phenotype0.82692098
110MP0005499_abnormal_olfactory_system0.82692098
111MP0003011_delayed_dark_adaptation0.82212811
112MP0005187_abnormal_penis_morphology0.81793835
113MP0006292_abnormal_olfactory_placode0.81307797
114MP0002638_abnormal_pupillary_reflex0.79860001
115MP0001963_abnormal_hearing_physiology0.79859230
116MP0002063_abnormal_learning/memory/cond0.79541509
117MP0005076_abnormal_cell_differentiation0.79163744
118MP0003890_abnormal_embryonic-extraembry0.77609122
119MP0002572_abnormal_emotion/affect_behav0.77042841
120MP0004858_abnormal_nervous_system0.76820439
121MP0005423_abnormal_somatic_nervous0.74732020
122MP0002882_abnormal_neuron_morphology0.74680911
123MP0000639_abnormal_adrenal_gland0.74091263
124* MP0003795_abnormal_bone_structure0.73825111
125MP0003091_abnormal_cell_migration0.73763172
126MP0003868_abnormal_feces_composition0.73492553
127MP0003635_abnormal_synaptic_transmissio0.71032030
128MP0002736_abnormal_nociception_after0.70845140
129MP0003283_abnormal_digestive_organ0.70672079
130MP0002009_preneoplasia0.69861605
131MP0003119_abnormal_digestive_system0.67597691
132MP0001177_atelectasis0.66957873
133MP0002697_abnormal_eye_size0.66050156
134MP0000613_abnormal_salivary_gland0.65851346
135MP0010771_integument_phenotype0.65771365
136MP0003566_abnormal_cell_adhesion0.63224755
137MP0005381_digestive/alimentary_phenotyp0.63086101

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.36675241
2Irregular epiphyses (HP:0010582)6.11613795
3Vitreoretinal degeneration (HP:0000655)6.10642523
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.77912472
5Hypoplastic ischia (HP:0003175)4.70685928
6Cupped ribs (HP:0000887)4.32401802
7Abnormality of the ischium (HP:0003174)4.17581404
8* Neonatal short-limb short stature (HP:0008921)4.15667633
9Genu varum (HP:0002970)4.05507806
10Flat capital femoral epiphysis (HP:0003370)3.97538726
11Small epiphyses (HP:0010585)3.92729565
12Abnormal tarsal ossification (HP:0008369)3.90624870
13Abnormality of the middle phalanges of the toes (HP:0010183)3.84973456
14Flat acetabular roof (HP:0003180)3.71400528
15Aplasia involving bones of the extremities (HP:0009825)3.71064940
16Aplasia involving bones of the upper limbs (HP:0009823)3.71064940
17Aplasia of the phalanges of the hand (HP:0009802)3.71064940
18Abnormality of the phalanges of the 2nd finger (HP:0009541)3.63773615
19Delayed epiphyseal ossification (HP:0002663)3.40442168
20Abnormality of incisor morphology (HP:0011063)3.32024869
21Short femoral neck (HP:0100864)3.31841717
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.27647052
23Abnormality of the diencephalon (HP:0010662)3.20499316
24Esophageal atresia (HP:0002032)3.17769342
25Abnormality of the phalanges of the 5th finger (HP:0004213)3.12258157
26Mixed hearing impairment (HP:0000410)3.11818714
27Osteoarthritis (HP:0002758)3.10848883
28Megalencephaly (HP:0001355)3.10582616
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.06854897
30Abnormality of the 2nd finger (HP:0004100)3.01625317
31Alacrima (HP:0000522)2.91912816
32Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.91154175
33Abnormality of the pubic bones (HP:0003172)2.84621533
34Split foot (HP:0001839)2.82784025
35Partial duplication of thumb phalanx (HP:0009944)2.81780928
36Abnormality of the nasal septum (HP:0000419)2.76286535
37Abnormal ciliary motility (HP:0012262)2.74419847
38Short 4th metacarpal (HP:0010044)2.73157815
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73157815
40Metaphyseal irregularity (HP:0003025)2.64922956
41Abnormal foot bone ossification (HP:0010675)2.64625749
42Arthropathy (HP:0003040)2.61690746
43Abnormal respiratory motile cilium physiology (HP:0012261)2.59833109
44Limited hip movement (HP:0008800)2.58077905
45Down-sloping shoulders (HP:0200021)2.55884079
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.55552904
47Absent epiphyses (HP:0010577)2.55531202
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.55531202
49Flattened epiphyses (HP:0003071)2.54859299
50Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.54780250
51Abnormality of femoral epiphyses (HP:0006499)2.54780250
52Abnormality of carpal bone ossification (HP:0006257)2.53923030
53Shallow orbits (HP:0000586)2.52128212
54Anophthalmia (HP:0000528)2.51263879
55Decreased lacrimation (HP:0000633)2.50069027
56Aplasia/hypoplasia of the femur (HP:0005613)2.49551788
57Gastrointestinal atresia (HP:0002589)2.48961831
58Partial duplication of the phalanx of hand (HP:0009999)2.41888527
59Limited elbow extension (HP:0001377)2.41313809
60Trigonocephaly (HP:0000243)2.40576066
61Concave nail (HP:0001598)2.40436982
62Mild short stature (HP:0003502)2.39112441
63Abnormality of the middle phalanges of the hand (HP:0009833)2.38909336
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.38477441
65Abnormality of the 4th metacarpal (HP:0010012)2.37890600
66Supernumerary ribs (HP:0005815)2.37785238
67Abnormality of the vertebral endplates (HP:0005106)2.34554436
68Hemiparesis (HP:0001269)2.34362470
69Humeroradial synostosis (HP:0003041)2.30840583
70Synostosis involving the elbow (HP:0003938)2.30840583
71Broad face (HP:0000283)2.29598391
72Barrel-shaped chest (HP:0001552)2.28428609
73Short middle phalanx of finger (HP:0005819)2.27174700
74Coronal craniosynostosis (HP:0004440)2.26796020
75Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.26226474
76Protuberant abdomen (HP:0001538)2.24456367
77Exostoses (HP:0100777)2.20284243
78Deep venous thrombosis (HP:0002625)2.19911960
79Vertebral arch anomaly (HP:0008438)2.19651974
80Abnormality of the epiphysis of the femoral head (HP:0010574)2.18253025
81Rhinitis (HP:0012384)2.18203555
82Onycholysis (HP:0001806)2.16344519
83Morphological abnormality of the inner ear (HP:0011390)2.15991287
84Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15584561
85Midline defect of the nose (HP:0004122)2.15435117
86Septo-optic dysplasia (HP:0100842)2.14281460
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13796384
88Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12884533
89Abnormal hand bone ossification (HP:0010660)2.11904670
90Supernumerary bones of the axial skeleton (HP:0009144)2.10586870
91Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.09351483
92Abnormality of the femoral head (HP:0003368)2.07910875
93Hypoplastic pelvis (HP:0008839)2.07723033
94Hemivertebrae (HP:0002937)2.06479171
95Hip contracture (HP:0003273)2.06472098
96Synostosis of carpal bones (HP:0005048)2.05141016
97Cervical subluxation (HP:0003308)2.05017077
98Oligodactyly (HP:0012165)2.04487321
99Micromelia (HP:0002983)2.03950118
100Preaxial foot polydactyly (HP:0001841)2.03345264
101Milia (HP:0001056)2.03321565
102Abnormality of the distal phalanges of the toes (HP:0010182)2.02282934
103* Bronchomalacia (HP:0002780)2.00875178
104Thickened helices (HP:0000391)2.00534887
105Abnormal ossification of hand bones (HP:0005921)2.00436780
106Arterial tortuosity (HP:0005116)1.99918892
107Natal tooth (HP:0000695)1.99754763
108Abnormality of the aortic arch (HP:0012303)1.99664683
109Coxa vara (HP:0002812)1.97744861
110Facial hemangioma (HP:0000329)1.97160831
111Follicular hyperkeratosis (HP:0007502)1.96460486
112Cutaneous finger syndactyly (HP:0010554)1.95989655
113Short hallux (HP:0010109)1.94162921
114Hamartoma (HP:0010566)1.93521466
115* Bifid scrotum (HP:0000048)1.91508384
116Broad long bones (HP:0005622)1.90978827
117Oligodactyly (hands) (HP:0001180)1.90357098
118Irregular vertebral endplates (HP:0003301)1.90075441
119Broad thumb (HP:0011304)1.87775661
120Mesomelia (HP:0003027)1.86924204
121Arnold-Chiari malformation (HP:0002308)1.86654313
122* Fibular hypoplasia (HP:0003038)1.85658411
123Thoracolumbar scoliosis (HP:0002944)1.85615260
124Absent frontal sinuses (HP:0002688)1.85608236
125* Abnormal vertebral ossification (HP:0100569)1.85023730
126Broad phalanx (HP:0006009)1.84741215
127Heterotopia (HP:0002282)1.82964336
128Platyspondyly (HP:0000926)1.82064970
129Hepatoblastoma (HP:0002884)1.81877215
130Severe Myopia (HP:0011003)1.81734479
131Morphological abnormality of the middle ear (HP:0008609)1.81249806
132Overriding aorta (HP:0002623)1.79849779
133Neonatal death (HP:0003811)1.78779105
134Stillbirth (HP:0003826)1.78410879
135Turricephaly (HP:0000262)1.78059089
136Renal hypoplasia (HP:0000089)1.77986454
137Abnormality of the axillary hair (HP:0100134)1.77357072
138Abnormality of secondary sexual hair (HP:0009888)1.77357072
139Abnormal respiratory epithelium morphology (HP:0012253)1.76523423
140Abnormal respiratory motile cilium morphology (HP:0005938)1.76523423
141Metaphyseal dysplasia (HP:0100255)1.76510445
142Abnormality of the incisor (HP:0000676)1.76457576
143Increased nuchal translucency (HP:0010880)1.76089930
144Metaphyseal cupping (HP:0003021)1.75851670
145* Abnormality of the fibula (HP:0002991)1.75735126
146Neoplasm of the heart (HP:0100544)1.74988798
147Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74985018
148Fragile nails (HP:0001808)1.74670654
149Vertebral clefting (HP:0008428)1.73655577
150Rib fusion (HP:0000902)1.73033405
151Atonic seizures (HP:0010819)1.72644981
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72226639
153Abnormality of permanent molar morphology (HP:0011071)1.67752794
154Abnormality of the dental root (HP:0006486)1.67752794
155Taurodontia (HP:0000679)1.67752794
156Abnormality of the parietal bone (HP:0002696)1.67082897
157Pterygium (HP:0001059)1.66893320
158* Laryngomalacia (HP:0001601)1.66562006
159Ulnar bowing (HP:0003031)1.66429988
160Elfin facies (HP:0004428)1.66192486
161Broad hallux (HP:0010055)1.63693771
162Conical tooth (HP:0000698)1.63001897
163Vascular tortuosity (HP:0004948)1.62883658
164Optic nerve hypoplasia (HP:0000609)1.61847165
165Epidermoid cyst (HP:0200040)1.61670697
166Cutaneous syndactyly (HP:0012725)1.60738418
167Broad toe (HP:0001837)1.58504358
168Renal duplication (HP:0000075)1.56564209
169Skin pits (HP:0100276)1.56110766
170Abnormality of the labia minora (HP:0012880)1.55242274
171Abnormality of the dental pulp (HP:0006479)1.54731825
172Aplasia/Hypoplasia of the ulna (HP:0006495)1.54468285
173Broad metatarsal (HP:0001783)1.54203876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.13601301
2DDR24.40721223
3EPHB24.13487994
4WEE13.49107935
5MAP3K33.06707120
6MKNK22.98518755
7ERBB32.88865207
8MST42.78438782
9MKNK12.77127394
10CASK2.76964155
11TSSK62.70894352
12STK38L2.69258724
13NME12.52693676
14STK242.23686728
15BCR2.16441006
16LATS12.10684006
17MAPK152.06460272
18MARK12.03749041
19LMTK21.91777587
20PRKG21.87417030
21MUSK1.82291091
22NUAK11.81002395
23SIK11.76675472
24CDK121.63995626
25EPHA41.54727671
26TYRO31.54173282
27TNIK1.52247055
28PRKD31.51683387
29DYRK1A1.42601424
30PBK1.36363780
31CDK31.36353756
32NTRK21.35477046
33CAMK1G1.32171446
34MAP3K101.29357782
35WNK41.26790841
36FGFR41.25811857
37NTRK31.25669850
38NEK61.25209491
39CAMK1D1.24283705
40FGFR31.23876702
41NTRK11.21849508
42EPHA31.21831497
43SIK31.20253277
44BMPR1B1.19991565
45NLK1.19946714
46PDGFRA1.18294191
47IRAK11.17711887
48FER1.17469560
49BRSK21.14157456
50TRPM71.12491853
51VRK11.10512404
52KSR11.05025447
53STK31.02843811
54ROCK21.01763847
55PTK20.99938934
56FGFR20.97185340
57PHKG20.94488638
58PHKG10.94488638
59PLK20.94468338
60FGFR10.92394936
61IRAK20.90089679
62MAP2K20.89569160
63SGK20.85370980
64MAPK70.84200211
65WNK10.82935333
66YES10.82007640
67SIK20.80096856
68PAK20.79630963
69ICK0.78350963
70* ROCK10.77635607
71PRKCE0.77457186
72SGK4940.76218201
73SGK2230.76218201
74MST1R0.74025522
75MELK0.73635068
76MAPK130.73252404
77PKN10.70241260
78BRSK10.70110630
79PAK30.69244656
80BMPR20.68021948
81GRK10.65362480
82GSK3A0.63911112
83IRAK30.62873306
84EPHA20.62775077
85NEK90.62617948
86DMPK0.62183966
87RIPK10.61739046
88ERBB20.56308746
89MAP3K20.54754668
90PIK3CA0.53632176
91STK160.53314180
92AKT30.53300140
93CDK80.53260151
94MTOR0.52549524
95PRKD20.49998524
96PKN20.49975163
97BUB10.49857167
98MET0.49752641
99ADRBK10.49033625
100MAPK120.45877804
101MAPK40.45471292
102DYRK20.45043035
103CAMK2A0.43947247
104MAPKAPK50.43918800
105CDC42BPA0.43327587
106AKT20.42580573
107PDGFRB0.42277040
108BRD40.41450981
109PLK30.40933251
110PTK60.40839055
111EPHB10.39977813
112CSNK1A1L0.39012556
113TRIB30.38966814
114CSNK1G10.38867907
115MAP2K10.38852309
116PRKG10.37577198
117NEK20.36875885
118PRKCI0.36156444
119STK390.35922917
120ERBB40.35685189
121TLK10.35076778
122MAPK90.34015516
123PAK60.33062236
124TAOK20.32998315
125IGF1R0.32699807
126RET0.32350202
127DYRK30.31975394
128MAPK100.31600424
129PRKCZ0.31471860
130CAMK2B0.31289223
131SGK10.31196095
132LATS20.30243673
133TAOK10.28665827
134* PRKACA0.28371165
135UHMK10.28208414
136PRKCA0.27349268
137PRKCG0.27016196
138EIF2AK20.26638273
139CAMK2D0.25841732
140SGK30.25763424
141HIPK20.25761200
142MAP3K70.25195143
143CSNK1E0.24846782
144PTK2B0.23438892
145STK380.23119789

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.00282170
2Basal cell carcinoma_Homo sapiens_hsa052173.77213424
3Protein digestion and absorption_Homo sapiens_hsa049743.37982877
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.37977054
5Hedgehog signaling pathway_Homo sapiens_hsa043402.89783135
6TGF-beta signaling pathway_Homo sapiens_hsa043502.69339345
7Hippo signaling pathway_Homo sapiens_hsa043902.46507711
8Notch signaling pathway_Homo sapiens_hsa043302.26289702
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.07495246
10Wnt signaling pathway_Homo sapiens_hsa043101.97205077
11Nitrogen metabolism_Homo sapiens_hsa009101.94623649
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.86330029
13Melanogenesis_Homo sapiens_hsa049161.83915602
14Dorso-ventral axis formation_Homo sapiens_hsa043201.83733322
15Axon guidance_Homo sapiens_hsa043601.73060798
16Sphingolipid metabolism_Homo sapiens_hsa006001.70002265
17Estrogen signaling pathway_Homo sapiens_hsa049151.69151602
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68446061
19Focal adhesion_Homo sapiens_hsa045101.50645505
20Prion diseases_Homo sapiens_hsa050201.49282485
21Sulfur metabolism_Homo sapiens_hsa009201.47431094
22Proteoglycans in cancer_Homo sapiens_hsa052051.46592312
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46588655
24Complement and coagulation cascades_Homo sapiens_hsa046101.36995351
25Fatty acid biosynthesis_Homo sapiens_hsa000611.34605131
26Bile secretion_Homo sapiens_hsa049761.33169833
27Arachidonic acid metabolism_Homo sapiens_hsa005901.30820333
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27828351
29Adherens junction_Homo sapiens_hsa045201.26421907
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25193920
31Malaria_Homo sapiens_hsa051441.24265689
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18913712
33Steroid biosynthesis_Homo sapiens_hsa001001.17991122
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14723337
35Circadian rhythm_Homo sapiens_hsa047101.14419015
36Colorectal cancer_Homo sapiens_hsa052101.12711674
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08776845
38Gastric acid secretion_Homo sapiens_hsa049711.04978505
39MicroRNAs in cancer_Homo sapiens_hsa052061.04469054
40Endometrial cancer_Homo sapiens_hsa052131.03953542
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01652194
42Bladder cancer_Homo sapiens_hsa052191.00578145
43Retinol metabolism_Homo sapiens_hsa008301.00288667
44Tight junction_Homo sapiens_hsa045300.99866507
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96571436
46Mineral absorption_Homo sapiens_hsa049780.95961802
47Salivary secretion_Homo sapiens_hsa049700.95888024
48Fatty acid metabolism_Homo sapiens_hsa012120.92620082
49Pathways in cancer_Homo sapiens_hsa052000.91662965
50Olfactory transduction_Homo sapiens_hsa047400.90787059
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90038428
52Melanoma_Homo sapiens_hsa052180.88635710
53Ovarian steroidogenesis_Homo sapiens_hsa049130.87574001
54Long-term depression_Homo sapiens_hsa047300.87100358
55Renal cell carcinoma_Homo sapiens_hsa052110.86920002
56Fat digestion and absorption_Homo sapiens_hsa049750.85834501
57Histidine metabolism_Homo sapiens_hsa003400.85405494
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84982141
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82994436
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82973174
61Ether lipid metabolism_Homo sapiens_hsa005650.82843204
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82295920
63Arginine and proline metabolism_Homo sapiens_hsa003300.80161512
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78711570
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78592604
66Pancreatic secretion_Homo sapiens_hsa049720.78115158
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77870182
68Gap junction_Homo sapiens_hsa045400.77588685
69Rap1 signaling pathway_Homo sapiens_hsa040150.77528733
70Dopaminergic synapse_Homo sapiens_hsa047280.77071911
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75321812
72Thyroid hormone synthesis_Homo sapiens_hsa049180.73870305
73Serotonergic synapse_Homo sapiens_hsa047260.71876164
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71563894
75Cocaine addiction_Homo sapiens_hsa050300.69758978
76Dilated cardiomyopathy_Homo sapiens_hsa054140.69068834
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69047212
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68393014
79Glioma_Homo sapiens_hsa052140.67640386
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67582972
81Prostate cancer_Homo sapiens_hsa052150.67311973
82Renin secretion_Homo sapiens_hsa049240.64556585
83Ras signaling pathway_Homo sapiens_hsa040140.63239671
84Taste transduction_Homo sapiens_hsa047420.62576277
85Linoleic acid metabolism_Homo sapiens_hsa005910.61091994
86Circadian entrainment_Homo sapiens_hsa047130.61047049
87GABAergic synapse_Homo sapiens_hsa047270.60903922
88Propanoate metabolism_Homo sapiens_hsa006400.60433195
89Glutamatergic synapse_Homo sapiens_hsa047240.60227751
90Glycerolipid metabolism_Homo sapiens_hsa005610.59859243
91Vitamin B6 metabolism_Homo sapiens_hsa007500.59777398
92Phototransduction_Homo sapiens_hsa047440.58823106
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57981717
94Vitamin digestion and absorption_Homo sapiens_hsa049770.57066174
95Starch and sucrose metabolism_Homo sapiens_hsa005000.56900037
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56028160
97Cholinergic synapse_Homo sapiens_hsa047250.54391668
98Lysine degradation_Homo sapiens_hsa003100.54074659
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53987742
100Small cell lung cancer_Homo sapiens_hsa052220.53947460
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53566582
102Butanoate metabolism_Homo sapiens_hsa006500.53409717
103Insulin secretion_Homo sapiens_hsa049110.53377457
104MAPK signaling pathway_Homo sapiens_hsa040100.53238015
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.52173368
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51611458
107Amoebiasis_Homo sapiens_hsa051460.50604621
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50414368
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50276702
110GnRH signaling pathway_Homo sapiens_hsa049120.49840743
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49609732
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.49390097
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49388343
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49220274
115Chemical carcinogenesis_Homo sapiens_hsa052040.49169811
116PPAR signaling pathway_Homo sapiens_hsa033200.48824140
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48558197
118Choline metabolism in cancer_Homo sapiens_hsa052310.47987609
119Calcium signaling pathway_Homo sapiens_hsa040200.47002463
120Chronic myeloid leukemia_Homo sapiens_hsa052200.45921607
121ErbB signaling pathway_Homo sapiens_hsa040120.45750317
122HTLV-I infection_Homo sapiens_hsa051660.45483285
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.43679620
124Long-term potentiation_Homo sapiens_hsa047200.43301746
125AMPK signaling pathway_Homo sapiens_hsa041520.41557537
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41342380
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40601135
128Autoimmune thyroid disease_Homo sapiens_hsa053200.40519263
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38626932
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38427609
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37670207
132* cAMP signaling pathway_Homo sapiens_hsa040240.35993127
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35832711
134Glutathione metabolism_Homo sapiens_hsa004800.34798071
135Amphetamine addiction_Homo sapiens_hsa050310.33636934
136Nicotine addiction_Homo sapiens_hsa050330.33197132

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