SP140L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.80216022
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15480365
3negative regulation of cell killing (GO:0031342)5.15480365
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90978886
5regulation of B cell receptor signaling pathway (GO:0050855)4.85415114
6antigen processing and presentation of endogenous antigen (GO:0019883)4.79865337
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77705192
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.75971937
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53736861
10negative thymic T cell selection (GO:0045060)4.41518925
11negative T cell selection (GO:0043383)4.39219097
12regulation of gamma-delta T cell activation (GO:0046643)4.32868653
13regulation of gamma-delta T cell differentiation (GO:0045586)4.16493963
14response to interleukin-15 (GO:0070672)3.93302706
15positive thymic T cell selection (GO:0045059)3.88660408
16cellular response to interleukin-15 (GO:0071350)3.86250080
17T cell migration (GO:0072678)3.78079313
18negative regulation of T cell mediated immunity (GO:0002710)3.72098812
19response to type I interferon (GO:0034340)3.70549706
20positive regulation of B cell differentiation (GO:0045579)3.69903974
21type I interferon signaling pathway (GO:0060337)3.69200869
22cellular response to type I interferon (GO:0071357)3.69200869
23positive T cell selection (GO:0043368)3.67936630
24regulation of B cell differentiation (GO:0045577)3.63976591
25immunoglobulin mediated immune response (GO:0016064)3.58307056
26B cell receptor signaling pathway (GO:0050853)3.58076250
27positive regulation of defense response to virus by host (GO:0002230)3.56234867
28leukocyte aggregation (GO:0070486)3.52591384
29tolerance induction (GO:0002507)3.52095928
30regulation of T cell mediated cytotoxicity (GO:0001914)3.51817039
31T cell selection (GO:0045058)3.50443721
32interferon-gamma production (GO:0032609)3.49966998
33positive regulation of granulocyte differentiation (GO:0030854)3.48518110
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43249415
35thymic T cell selection (GO:0045061)3.41722713
36positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41229788
37regulation of alpha-beta T cell proliferation (GO:0046640)3.39931105
38negative regulation of interleukin-12 production (GO:0032695)3.38075738
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.34190792
40activated T cell proliferation (GO:0050798)3.31684687
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30585117
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29552706
43regulation of regulatory T cell differentiation (GO:0045589)3.28544704
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28198591
45regulation of antigen processing and presentation (GO:0002577)3.23744353
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19422326
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.17987385
48regulation of natural killer cell mediated immunity (GO:0002715)3.17987385
49positive regulation of antigen processing and presentation (GO:0002579)3.17649173
50mast cell activation (GO:0045576)3.15713004
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.15372225
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14456029
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14456029
54positive regulation by organism of defense response of other organism involved in symbiotic interact3.14456029
55modulation by symbiont of host immune response (GO:0052553)3.14456029
56positive regulation by symbiont of host defense response (GO:0052509)3.14456029
57modulation by symbiont of host defense response (GO:0052031)3.14456029
58interferon-gamma-mediated signaling pathway (GO:0060333)3.14272113
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13995138
60defense response to protozoan (GO:0042832)3.13287595
61antigen receptor-mediated signaling pathway (GO:0050851)3.07364315
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.06065193
63regulation of T cell tolerance induction (GO:0002664)3.02297110
64detection of bacterium (GO:0016045)2.98063355
65detection of other organism (GO:0098543)2.95544662
66response to interferon-beta (GO:0035456)2.95368200
67cellular response to exogenous dsRNA (GO:0071360)2.95079643
68regulation of isotype switching to IgG isotypes (GO:0048302)2.94353876
69positive regulation of natural killer cell differentiation (GO:0032825)2.94158020
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.90340740
71response to protozoan (GO:0001562)2.89761873
72regulation of cell killing (GO:0031341)2.89651308
73T cell receptor signaling pathway (GO:0050852)2.89618444
74negative regulation of leukocyte mediated immunity (GO:0002704)2.89404386
75regulation of interferon-beta biosynthetic process (GO:0045357)2.89278699
76cytidine metabolic process (GO:0046087)2.88528749
77cytidine catabolic process (GO:0006216)2.88528749
78cytidine deamination (GO:0009972)2.88528749
79actin nucleation (GO:0045010)2.87273043
80B cell mediated immunity (GO:0019724)2.85456694
81negative regulation of innate immune response (GO:0045824)2.85093284
82positive regulation of DNA recombination (GO:0045911)2.84493274
83positive regulation of isotype switching (GO:0045830)2.82863963
84neutrophil activation involved in immune response (GO:0002283)2.82861879
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.82325689
86negative regulation of viral genome replication (GO:0045071)2.80434019
87regulation of tolerance induction (GO:0002643)2.79978367
88negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79473440
89positive regulation of tolerance induction (GO:0002645)2.79218911
90NIK/NF-kappaB signaling (GO:0038061)2.78795994
91DNA deamination (GO:0045006)2.78738278
92interferon-gamma secretion (GO:0072643)2.78485393
93regulation of T cell receptor signaling pathway (GO:0050856)2.78370840
94regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.76961862
95regulation of defense response to virus by host (GO:0050691)2.76882195
96regulation of interferon-alpha production (GO:0032647)2.76387909
97antigen processing and presentation via MHC class Ib (GO:0002475)2.75651592
98regulation of T-helper 1 cell differentiation (GO:0045625)2.75032774
99macrophage activation involved in immune response (GO:0002281)2.74710389
100mast cell activation involved in immune response (GO:0002279)2.73772078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.42059993
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.06657910
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.80710600
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43052172
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.92108391
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.56729422
7RUNX_20019798_ChIP-Seq_JUKART_Human3.23898286
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08041956
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.07312084
10* MYB_26560356_Chip-Seq_TH2_Human2.93893182
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67931054
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67336590
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.61367123
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55181598
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44401736
16MYB_26560356_Chip-Seq_TH1_Human2.38752353
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33234908
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29663044
19SCL_19346495_ChIP-Seq_HPC-7_Human2.27782950
20SPI1_23547873_ChIP-Seq_NB4_Human2.23796784
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21493488
22GATA3_26560356_Chip-Seq_TH2_Human2.09288154
23MAF_26560356_Chip-Seq_TH1_Human2.08195799
24* GATA3_27048872_Chip-Seq_THYMUS_Human2.05730510
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04292136
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00354083
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99271372
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.95916864
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88147971
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84192219
31UTX_26944678_Chip-Seq_JUKART_Human1.76173627
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75713839
33SPI1_23127762_ChIP-Seq_K562_Human1.73259838
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64433467
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61047715
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.60545071
37MAF_26560356_Chip-Seq_TH2_Human1.58177158
38VDR_24763502_ChIP-Seq_THP-1_Human1.56904796
39GATA1_22025678_ChIP-Seq_K562_Human1.54332581
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53193261
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.53120418
42VDR_24787735_ChIP-Seq_THP-1_Human1.51914724
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50385565
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44918312
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42313381
46MYC_22102868_ChIP-Seq_BL_Human1.38786757
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32397312
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24368164
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24244754
50VDR_21846776_ChIP-Seq_THP-1_Human1.19222837
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17201557
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17156932
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12021831
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12015458
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09111278
56VDR_23849224_ChIP-Seq_CD4+_Human1.08206256
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06827801
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05235617
59CIITA_25753668_ChIP-Seq_RAJI_Human1.04704508
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.03776458
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.02892745
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01955296
63* BCL6_27268052_Chip-Seq_Bcells_Human1.00993470
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99706088
65FLI1_27457419_Chip-Seq_LIVER_Mouse0.99660744
66* SMRT_27268052_Chip-Seq_Bcells_Human0.96231570
67PU_27001747_Chip-Seq_BMDM_Mouse0.95723218
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95340140
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94605173
70P300_27268052_Chip-Seq_Bcells_Human0.93357453
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92600962
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92294798
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91397460
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90731394
75GATA3_26560356_Chip-Seq_TH1_Human0.90159767
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89271200
77STAT1_20625510_ChIP-Seq_HELA_Human0.89120277
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88269129
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86953653
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85737280
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84794995
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84400437
83GATA1_19941826_ChIP-Seq_K562_Human0.83674046
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83368790
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82004497
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81081657
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.80788475
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80635198
89BCOR_27268052_Chip-Seq_Bcells_Human0.79762793
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77915002
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77789717
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77285268
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75284713
94* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73583708
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72387462
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71569843
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69875717
98GATA2_19941826_ChIP-Seq_K562_Human0.69077751
99SPI1_20517297_ChIP-Seq_HL60_Human0.68391351
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68353766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.13471258
2MP0005671_abnormal_response_to3.78492154
3MP0003724_increased_susceptibility_to3.58023394
4MP0003436_decreased_susceptibility_to3.33005966
5MP0001800_abnormal_humoral_immune3.30769950
6MP0003763_abnormal_thymus_physiology3.20405981
7MP0000685_abnormal_immune_system3.13075482
8MP0009785_altered_susceptibility_to3.09299586
9MP0001790_abnormal_immune_system3.08551436
10MP0005387_immune_system_phenotype3.08551436
11MP0005000_abnormal_immune_tolerance3.08013606
12MP0002723_abnormal_immune_serum2.81875475
13MP0005025_abnormal_response_to2.70646958
14MP0002452_abnormal_antigen_presenting2.69198309
15MP0002148_abnormal_hypersensitivity_rea2.66014654
16MP0002420_abnormal_adaptive_immunity2.59562932
17MP0001819_abnormal_immune_cell2.57039870
18MP0006082_CNS_inflammation2.55341053
19MP0002419_abnormal_innate_immunity2.49806989
20MP0003303_peritoneal_inflammation2.34160494
21MP0002405_respiratory_system_inflammati2.15577378
22MP0002398_abnormal_bone_marrow2.08778880
23MP0010155_abnormal_intestine_physiology2.07939139
24MP0000716_abnormal_immune_system2.03054867
25MP0009333_abnormal_splenocyte_physiolog2.00781964
26MP0001873_stomach_inflammation1.84292664
27MP0001845_abnormal_inflammatory_respons1.84099065
28MP0000689_abnormal_spleen_morphology1.83403344
29MP0001533_abnormal_skeleton_physiology1.78707657
30MP0005464_abnormal_platelet_physiology1.76369592
31MP0002138_abnormal_hepatobiliary_system1.71537811
32MP0002722_abnormal_immune_system1.71129723
33MP0003866_abnormal_defecation1.70702757
34MP0003300_gastrointestinal_ulcer1.69538199
35MP0009764_decreased_sensitivity_to1.65270686
36MP0004947_skin_inflammation1.62849625
37MP0002429_abnormal_blood_cell1.59791573
38MP0005310_abnormal_salivary_gland1.57879587
39MP0000703_abnormal_thymus_morphology1.55172640
40MP0002166_altered_tumor_susceptibility1.53341139
41MP0008469_abnormal_protein_level1.52196202
42MP0002933_joint_inflammation1.31885710
43MP0003172_abnormal_lysosome_physiology1.31854949
44MP0005075_abnormal_melanosome_morpholog1.28517735
45MP0002132_abnormal_respiratory_system1.27271020
46MP0003191_abnormal_cellular_cholesterol1.19645394
47MP0003806_abnormal_nucleotide_metabolis1.19320132
48MP0002396_abnormal_hematopoietic_system1.18075159
49MP0004381_abnormal_hair_follicle1.17477218
50MP0000465_gastrointestinal_hemorrhage1.15206634
51MP0002006_tumorigenesis1.12985273
52MP0003183_abnormal_peptide_metabolism1.11950014
53MP0003252_abnormal_bile_duct1.11671638
54MP0009278_abnormal_bone_marrow1.09860606
55MP0001853_heart_inflammation1.08875718
56MP0005397_hematopoietic_system_phenotyp1.08089369
57MP0001545_abnormal_hematopoietic_system1.08089369
58MP0001986_abnormal_taste_sensitivity1.02425576
59MP0000858_altered_metastatic_potential0.98535492
60MP0003195_calcinosis0.97454637
61MP0001663_abnormal_digestive_system0.97276281
62MP0003045_fibrosis0.97228601
63MP0009763_increased_sensitivity_to0.94230346
64MP0001851_eye_inflammation0.93554236
65MP0004883_abnormal_blood_vessel0.91467176
66MP0003656_abnormal_erythrocyte_physiolo0.89849614
67MP0005451_abnormal_body_composition0.84631152
68MP0002998_abnormal_bone_remodeling0.83776703
69MP0002876_abnormal_thyroid_physiology0.82589838
70MP0004808_abnormal_hematopoietic_stem0.81599529
71MP0005164_abnormal_response_to0.81313376
72MP0008875_abnormal_xenobiotic_pharmacok0.80653224
73MP0003828_pulmonary_edema0.76065855
74MP0000569_abnormal_digit_pigmentation0.75119891
75MP0009765_abnormal_xenobiotic_induced0.74926021
76MP0003448_altered_tumor_morphology0.72038479
77MP0005390_skeleton_phenotype0.71684129
78MP0002019_abnormal_tumor_incidence0.71042722
79MP0005058_abnormal_lysosome_morphology0.70696932
80MP0002163_abnormal_gland_morphology0.69908409
81MP0000015_abnormal_ear_pigmentation0.68970411
82MP0000249_abnormal_blood_vessel0.68910874
83MP0002693_abnormal_pancreas_physiology0.67545254
84MP0001501_abnormal_sleep_pattern0.66838266
85MP0005360_urolithiasis0.65891899
86MP0002254_reproductive_system_inflammat0.65796896
87MP0002136_abnormal_kidney_physiology0.65084350
88MP0008877_abnormal_DNA_methylation0.64807328
89MP0005166_decreased_susceptibility_to0.64476449
90MP0005174_abnormal_tail_pigmentation0.63256468
91MP0000604_amyloidosis0.61773163
92MP0002277_abnormal_respiratory_mucosa0.59248238
93MP0009840_abnormal_foam_cell0.58642253
94MP0005319_abnormal_enzyme/_coenzyme0.58356974
95MP0000609_abnormal_liver_physiology0.57801844
96MP0003646_muscle_fatigue0.57747704
97MP0002332_abnormal_exercise_endurance0.57038689
98MP0001764_abnormal_homeostasis0.55428677
99MP0003075_altered_response_to0.54332881
100MP0009643_abnormal_urine_homeostasis0.54003176

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.07115450
2Myositis (HP:0100614)4.85594355
3Stomatitis (HP:0010280)4.85105022
4T lymphocytopenia (HP:0005403)4.63105269
5Abnormality of T cell number (HP:0011839)4.58714120
6Optic neuritis (HP:0100653)4.52051392
7Retrobulbar optic neuritis (HP:0100654)4.52051392
8Orchitis (HP:0100796)4.37904680
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.15610234
10Recurrent fungal infections (HP:0002841)4.11243168
11Recurrent bacterial skin infections (HP:0005406)3.90509149
12Abnormality of T cells (HP:0002843)3.89509290
13Eczematoid dermatitis (HP:0000976)3.80120950
14Recurrent abscess formation (HP:0002722)3.75926237
15Chronic mucocutaneous candidiasis (HP:0002728)3.72316863
16Recurrent cutaneous fungal infections (HP:0011370)3.72316863
17Meningitis (HP:0001287)3.65834225
18Vasculitis (HP:0002633)3.63941542
19Pustule (HP:0200039)3.62872098
20Panhypogammaglobulinemia (HP:0003139)3.60528299
21IgG deficiency (HP:0004315)3.58282700
22Mediastinal lymphadenopathy (HP:0100721)3.57859443
23Encephalitis (HP:0002383)3.57028571
24Gastrointestinal infarctions (HP:0005244)3.54943487
25Pulmonary infiltrates (HP:0002113)3.54077752
26Recurrent viral infections (HP:0004429)3.49791289
27Severe combined immunodeficiency (HP:0004430)3.44992983
28Agammaglobulinemia (HP:0004432)3.41876236
29Autoimmune hemolytic anemia (HP:0001890)3.32902363
30Abnormality of macrophages (HP:0004311)3.31855755
31Increased IgM level (HP:0003496)3.30751356
32Abnormality of T cell physiology (HP:0011840)3.29749855
33Keratoconjunctivitis (HP:0001096)3.13211041
34Hemoptysis (HP:0002105)3.11922802
35Recurrent skin infections (HP:0001581)3.11693303
36Keratoconjunctivitis sicca (HP:0001097)3.09445324
37Recurrent bronchitis (HP:0002837)3.09146577
38Leukocytosis (HP:0001974)3.05583643
39Obstructive lung disease (HP:0006536)3.04725670
40Chronic obstructive pulmonary disease (HP:0006510)3.04725670
41Abnormality of eosinophils (HP:0001879)3.04599381
42Eosinophilia (HP:0001880)3.02611120
43Granulocytopenia (HP:0001913)3.01235150
44Autoimmune thrombocytopenia (HP:0001973)2.91669972
45Abnormality of B cell number (HP:0010975)2.87796600
46Abnormality of the prostate (HP:0008775)2.75369563
47Chronic diarrhea (HP:0002028)2.74028750
48Chest pain (HP:0100749)2.68779869
49Combined immunodeficiency (HP:0005387)2.64370693
50Arterial thrombosis (HP:0004420)2.63996548
51Prolonged bleeding time (HP:0003010)2.63642440
52Thyroiditis (HP:0100646)2.56158114
53Lymphopenia (HP:0001888)2.51670589
54Anorexia (HP:0002039)2.51335769
55Hypergammaglobulinemia (HP:0010702)2.46976041
56Abnormality of the pleura (HP:0002103)2.42836472
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.41601246
58Abnormality of liposaccharide metabolism (HP:0010968)2.40468257
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.40468257
60Abnormality of glycolipid metabolism (HP:0010969)2.40468257
61Pulmonary embolism (HP:0002204)2.40030434
62Epistaxis (HP:0000421)2.38539603
63Recurrent gram-negative bacterial infections (HP:0005420)2.37192104
64Gangrene (HP:0100758)2.37006606
65Urticaria (HP:0001025)2.35878830
66Spontaneous hematomas (HP:0007420)2.33751153
67Joint swelling (HP:0001386)2.30873825
68B lymphocytopenia (HP:0010976)2.30824268
69Gingival bleeding (HP:0000225)2.30571766
70Inflammation of the large intestine (HP:0002037)2.26791173
71Chronic otitis media (HP:0000389)2.24393514
72Papilloma (HP:0012740)2.22580561
73Verrucae (HP:0200043)2.22580561
74Keratitis (HP:0000491)2.21478795
75Recurrent sinusitis (HP:0011108)2.19107987
76Alveolar cell carcinoma (HP:0006519)2.18391740
77Increased IgE level (HP:0003212)2.15723397
78Stomach cancer (HP:0012126)2.11830954
79Acute hepatic failure (HP:0006554)2.11825399
80Polyneuropathy (HP:0001271)2.11775980
81Gastrointestinal inflammation (HP:0004386)2.11198854
82Gastrointestinal stroma tumor (HP:0100723)2.09757745
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07657226
84Hypochromic anemia (HP:0001931)2.07022390
85Increased serum ferritin (HP:0003281)2.05155087
86IgM deficiency (HP:0002850)2.04498031
87Neoplasm of the tracheobronchial system (HP:0100552)2.02510525
88Congenital stationary night blindness (HP:0007642)2.00804463
89Skin rash (HP:0000988)2.00588791
90Abnormality of iron homeostasis (HP:0011031)1.99353663
91Prostate neoplasm (HP:0100787)1.97679107
92Hypoproteinemia (HP:0003075)1.97292916
93Gingivitis (HP:0000230)1.94610251
94Abnormality of the pericardium (HP:0001697)1.94553689
95Abnormality of transition element cation homeostasis (HP:0011030)1.94542656
96Glomerulopathy (HP:0100820)1.92308111
97Vacuolated lymphocytes (HP:0001922)1.89739302
98Cellulitis (HP:0100658)1.89331025
99IgA deficiency (HP:0002720)1.89244459
100Episodic fever (HP:0001954)1.88324394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.31927376
2TXK4.18189185
3TAOK33.87057279
4RIPK42.77351061
5MAP3K142.70246970
6IRAK42.52890432
7TYK22.48401963
8IKBKE2.45466650
9BLK2.40164542
10ITK2.27758711
11FES2.27638912
12ZAP702.18346466
13SYK2.15107110
14BTK2.14320802
15JAK32.09520164
16GRK62.02381195
17IKBKB1.97832535
18TEC1.94966291
19TBK11.93393508
20KIT1.88544359
21CSK1.80035876
22JAK11.79244738
23FRK1.68201714
24ERN11.62990901
25ADRBK21.58941927
26LCK1.56722008
27BMPR21.51253469
28LYN1.46592148
29HCK1.45811350
30SIK31.44385017
31MAP3K131.40046888
32CSF1R1.37507325
33PRKCQ1.27423026
34TNK21.21335316
35MAP2K31.17430422
36CAMKK21.14959250
37MARK31.10497272
38PIK3CG1.09679303
39TLK11.03747597
40MATK0.97269305
41NUAK10.95609342
42MST40.94030169
43IRAK10.92373761
44GRK70.91760130
45JAK20.91048381
46MAP3K110.85967868
47TRPM70.85553689
48TGFBR20.83968890
49CHUK0.82217482
50MAP3K30.80825102
51NLK0.80640652
52MAP2K60.76358042
53KDR0.76001892
54ACVR1B0.73084164
55STK100.72562254
56BCKDK0.72560816
57PIM10.71713251
58EPHB10.71675627
59TESK20.68660771
60PTK2B0.68381345
61CDK40.67908118
62SIK20.65438731
63MAPKAPK30.65373204
64MAP3K70.64488169
65MAP4K20.62915920
66MAPK110.61496490
67PDK10.61293183
68WNK40.60470675
69HIPK20.60469431
70PRPF4B0.60209214
71GRK10.58676296
72PINK10.57321001
73FGFR30.56999390
74MAPK70.56205151
75CLK10.55018599
76ABL10.54780513
77ADRBK10.54184996
78MAP2K20.49602128
79FGR0.47120991
80FGFR40.46890541
81CAMKK10.46531834
82PIM20.44942757
83CDC42BPA0.43861262
84TAOK10.43082169
85FYN0.42579683
86MELK0.39488865
87PRKD20.38723874
88FLT30.38165161
89IGF1R0.36276416
90PASK0.35386961
91MAPK120.34892059
92MAP3K10.33727744
93BMPR1B0.33386846
94MAPK30.31263621
95PRKCD0.30220485
96IRAK30.29927060
97PIK3CA0.29258217
98INSR0.29151192
99MAPKAPK20.29118694
100EPHA30.24102075

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.02020300
2Graft-versus-host disease_Homo sapiens_hsa053323.65345322
3Allograft rejection_Homo sapiens_hsa053303.53450929
4Autoimmune thyroid disease_Homo sapiens_hsa053203.22267539
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.10826996
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78049677
7Asthma_Homo sapiens_hsa053102.72515150
8Type I diabetes mellitus_Homo sapiens_hsa049402.62180646
9Leishmaniasis_Homo sapiens_hsa051402.56617606
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.38386920
11Antigen processing and presentation_Homo sapiens_hsa046122.36207977
12Staphylococcus aureus infection_Homo sapiens_hsa051502.35839739
13Hematopoietic cell lineage_Homo sapiens_hsa046402.21209076
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19338703
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13971674
16T cell receptor signaling pathway_Homo sapiens_hsa046602.10376389
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07653761
18Osteoclast differentiation_Homo sapiens_hsa043802.05553631
19B cell receptor signaling pathway_Homo sapiens_hsa046621.97702933
20Measles_Homo sapiens_hsa051621.94104438
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90569340
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77838073
23Viral myocarditis_Homo sapiens_hsa054161.65153064
24Herpes simplex infection_Homo sapiens_hsa051681.60134118
25Tuberculosis_Homo sapiens_hsa051521.56490267
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.55802146
27Malaria_Homo sapiens_hsa051441.54792053
28Rheumatoid arthritis_Homo sapiens_hsa053231.53721547
29Influenza A_Homo sapiens_hsa051641.45888259
30Toxoplasmosis_Homo sapiens_hsa051451.43762529
31TNF signaling pathway_Homo sapiens_hsa046681.33065342
32Other glycan degradation_Homo sapiens_hsa005111.27971027
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27386911
34African trypanosomiasis_Homo sapiens_hsa051431.16765802
35Legionellosis_Homo sapiens_hsa051341.12093946
36Chemokine signaling pathway_Homo sapiens_hsa040621.10424113
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09069413
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02793495
39Pertussis_Homo sapiens_hsa051331.00274441
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00171638
41Acute myeloid leukemia_Homo sapiens_hsa052210.98667838
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98173787
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90688582
44Platelet activation_Homo sapiens_hsa046110.89332089
45Hepatitis B_Homo sapiens_hsa051610.89189115
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88965981
47Hepatitis C_Homo sapiens_hsa051600.88118806
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85739286
49Shigellosis_Homo sapiens_hsa051310.79350716
50Linoleic acid metabolism_Homo sapiens_hsa005910.79317295
51Lysosome_Homo sapiens_hsa041420.76616193
52Apoptosis_Homo sapiens_hsa042100.73143817
53Epstein-Barr virus infection_Homo sapiens_hsa051690.71426385
54Phagosome_Homo sapiens_hsa041450.67105505
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.64055372
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60893950
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57540654
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.57064329
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56189008
60ABC transporters_Homo sapiens_hsa020100.48839464
61Non-small cell lung cancer_Homo sapiens_hsa052230.47414866
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45143945
63HTLV-I infection_Homo sapiens_hsa051660.45051284
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44779016
65Arachidonic acid metabolism_Homo sapiens_hsa005900.41951329
66Ether lipid metabolism_Homo sapiens_hsa005650.40291553
67Prolactin signaling pathway_Homo sapiens_hsa049170.38851624
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.37916950
69Salmonella infection_Homo sapiens_hsa051320.37776814
70Regulation of autophagy_Homo sapiens_hsa041400.36985096
71Caffeine metabolism_Homo sapiens_hsa002320.34685958
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.32732809
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.32488692
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32341882
75VEGF signaling pathway_Homo sapiens_hsa043700.31899064
76Viral carcinogenesis_Homo sapiens_hsa052030.31701390
77Pancreatic cancer_Homo sapiens_hsa052120.31206279
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31121258
79Insulin resistance_Homo sapiens_hsa049310.27990713
80Glycerolipid metabolism_Homo sapiens_hsa005610.26936994
81MAPK signaling pathway_Homo sapiens_hsa040100.26815600
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25975538
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25044833
84Phototransduction_Homo sapiens_hsa047440.24234937
85Endocytosis_Homo sapiens_hsa041440.23115111
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21686583
87FoxO signaling pathway_Homo sapiens_hsa040680.21087627
88Dorso-ventral axis formation_Homo sapiens_hsa043200.20094162
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18993431
90Complement and coagulation cascades_Homo sapiens_hsa046100.18272128
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.18252506
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17080402
93Peroxisome_Homo sapiens_hsa041460.17001448
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16874644
95Systemic lupus erythematosus_Homo sapiens_hsa053220.16785094
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.16688070
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15466688
98Nitrogen metabolism_Homo sapiens_hsa009100.15330850
99Chemical carcinogenesis_Homo sapiens_hsa052040.13781288
100Chronic myeloid leukemia_Homo sapiens_hsa052200.11678958

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