SP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.51330768
2doxorubicin metabolic process (GO:0044598)9.51330768
3daunorubicin metabolic process (GO:0044597)9.51330768
4protein localization to kinetochore (GO:0034501)6.33586248
5maintenance of protein location in nucleus (GO:0051457)6.09237042
6aminoglycoside antibiotic metabolic process (GO:0030647)6.05362791
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.80416174
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.64763411
9regulation of telomere maintenance via telomerase (GO:0032210)5.61520860
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.60869441
11histone H4-K12 acetylation (GO:0043983)5.58893206
12somite rostral/caudal axis specification (GO:0032525)5.56958850
13regulation of response to osmotic stress (GO:0047484)5.48048909
14negative regulation of telomerase activity (GO:0051974)5.37683987
15mitotic sister chromatid segregation (GO:0000070)5.30543276
16negative regulation of cell cycle G2/M phase transition (GO:1902750)5.15965754
17histone H4-K8 acetylation (GO:0043982)5.14957730
18histone H4-K5 acetylation (GO:0043981)5.14957730
19negative regulation of epidermis development (GO:0045683)5.10597164
20positive regulation by symbiont of host defense response (GO:0052509)4.95669664
21modulation by symbiont of host defense response (GO:0052031)4.95669664
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95669664
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95669664
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.95669664
25modulation by symbiont of host immune response (GO:0052553)4.95669664
26negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.89081020
27positive regulation of gamma-delta T cell activation (GO:0046645)4.88795737
28negative regulation of cell killing (GO:0031342)4.88536855
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88536855
30rRNA transcription (GO:0009303)4.86626219
31protein localization to chromosome, centromeric region (GO:0071459)4.83358516
32heterochromatin organization (GO:0070828)4.70580904
33muscle organ morphogenesis (GO:0048644)4.66871167
34regulation of MHC class I biosynthetic process (GO:0045343)4.63245046
35sister chromatid segregation (GO:0000819)4.47258568
36positive regulation of DNA-dependent DNA replication (GO:2000105)4.45973438
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45361110
38negative regulation of erythrocyte differentiation (GO:0045647)4.39471443
39antigen processing and presentation of endogenous antigen (GO:0019883)4.39036145
40interferon-gamma production (GO:0032609)4.36466152
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36290289
42negative regulation of telomere maintenance (GO:0032205)4.34336312
43DNA replication-dependent nucleosome organization (GO:0034723)4.32501535
44DNA replication-dependent nucleosome assembly (GO:0006335)4.32501535
45DNA replication checkpoint (GO:0000076)4.31818834
46chromatin assembly (GO:0031497)4.21431339
47nuclear pore complex assembly (GO:0051292)4.17620717
48notochord development (GO:0030903)4.17327914
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17033494
50regulation of interferon-beta biosynthetic process (GO:0045357)4.09924313
51neutrophil activation involved in immune response (GO:0002283)4.06442468
52regulation of translation in response to stress (GO:0043555)4.04785695
53regulation of B cell receptor signaling pathway (GO:0050855)4.01044807
54negative regulation of epidermal cell differentiation (GO:0045605)3.97409352
55regulation of apoptotic process involved in morphogenesis (GO:1902337)3.95402000
56cytidine metabolic process (GO:0046087)3.93870566
57cytidine catabolic process (GO:0006216)3.93870566
58cytidine deamination (GO:0009972)3.93870566
59tolerance induction (GO:0002507)3.93746050
60NIK/NF-kappaB signaling (GO:0038061)3.93243701
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92458747
62histone H4-K16 acetylation (GO:0043984)3.90891422
63regulation of cilium movement (GO:0003352)3.89430386
64intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.88568905
65macrophage activation involved in immune response (GO:0002281)3.88029195
66response to peptidoglycan (GO:0032494)3.87517515
67regulation of gamma-delta T cell activation (GO:0046643)3.86369248
68rRNA methylation (GO:0031167)3.85079407
69leukocyte aggregation (GO:0070486)3.85017346
70branching involved in mammary gland duct morphogenesis (GO:0060444)3.84392893
71pre-miRNA processing (GO:0031054)3.82247753
72nucleoside transmembrane transport (GO:1901642)3.80922144
73primitive streak formation (GO:0090009)3.79026238
74nuclear pore organization (GO:0006999)3.75025013
75detection of other organism (GO:0098543)3.73357107
76detection of bacterium (GO:0016045)3.73259108
77positive regulation of protein deacetylation (GO:0090312)3.69365731
78RNA stabilization (GO:0043489)3.66891829
79mRNA stabilization (GO:0048255)3.66891829
80trophectodermal cell differentiation (GO:0001829)3.65356661
81rRNA modification (GO:0000154)3.62751676
82transcription from mitochondrial promoter (GO:0006390)3.59996596
83regulation of gamma-delta T cell differentiation (GO:0045586)3.57149203
84positive thymic T cell selection (GO:0045059)3.55528806
85cell fate commitment involved in formation of primary germ layer (GO:0060795)3.53990597
86retinoic acid receptor signaling pathway (GO:0048384)3.53888820
87thymic T cell selection (GO:0045061)3.51350260
88immunoglobulin mediated immune response (GO:0016064)3.49612763
89response to muramyl dipeptide (GO:0032495)3.47835657
90negative thymic T cell selection (GO:0045060)3.47156779
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.44172783
92maintenance of protein localization in organelle (GO:0072595)3.43779152
93regulation of gene silencing by miRNA (GO:0060964)3.42453558
94regulation of gene silencing by RNA (GO:0060966)3.42453558
95regulation of posttranscriptional gene silencing (GO:0060147)3.42453558
96positive regulation of histone deacetylation (GO:0031065)3.41126527
97hormone catabolic process (GO:0042447)3.40243536
98regulation of telomere maintenance (GO:0032204)3.38888709
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36214030
100phenol-containing compound catabolic process (GO:0019336)3.35090982
101formation of translation preinitiation complex (GO:0001731)3.34630981
102regulation of T-helper 2 cell differentiation (GO:0045628)3.32778589
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31983755
104response to host immune response (GO:0052572)3.31983755
105intestinal epithelial cell development (GO:0060576)3.31502196
106negative T cell selection (GO:0043383)3.30941799
107germinal center formation (GO:0002467)3.30785880
108type I interferon signaling pathway (GO:0060337)3.30692840
109cellular response to type I interferon (GO:0071357)3.30692840
110mitotic chromosome condensation (GO:0007076)3.29041366
111DNA duplex unwinding (GO:0032508)3.28069830
112response to type I interferon (GO:0034340)3.27421751
113regulation of telomerase activity (GO:0051972)3.27250055
114neutrophil activation (GO:0042119)3.25992553
115response to dietary excess (GO:0002021)3.24484277
116T cell selection (GO:0045058)3.24470266
117ribosome biogenesis (GO:0042254)3.24042696
118DNA geometric change (GO:0032392)3.23969721
119maternal placenta development (GO:0001893)3.23215329
120intracellular estrogen receptor signaling pathway (GO:0030520)3.22262940
121negative regulation of interleukin-12 production (GO:0032695)3.21967131
122regulation of mast cell degranulation (GO:0043304)3.20634259
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19835143
124response to host (GO:0075136)3.19835143
125response to host defenses (GO:0052200)3.19835143
126regulation of double-strand break repair (GO:2000779)3.18349780
127quinone metabolic process (GO:1901661)3.18021599
128granulocyte activation (GO:0036230)3.17744876
129response to interleukin-15 (GO:0070672)3.17596312
130regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.16662570
131regulation of T cell tolerance induction (GO:0002664)3.15671101
132pore complex assembly (GO:0046931)3.13788502
133intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.10196658
134cullin deneddylation (GO:0010388)3.08407782
135DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07714644
136negative regulation of phagocytosis (GO:0050765)3.03312427
137negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.01580521
138positive regulation of type 2 immune response (GO:0002830)3.01345178
139DNA unwinding involved in DNA replication (GO:0006268)3.01005599
1403-UTR-mediated mRNA stabilization (GO:0070935)3.00093601
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.98583339
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97682578
143B cell receptor signaling pathway (GO:0050853)2.97561256
144negative regulation of gene silencing (GO:0060969)2.97144518
145positive T cell selection (GO:0043368)2.95856560
146spindle assembly (GO:0051225)2.92902703
147apoptotic DNA fragmentation (GO:0006309)2.92255699
148detection of external biotic stimulus (GO:0098581)2.91848568
149regulation of DNA-dependent DNA replication (GO:0090329)2.90987373
150modulation by virus of host process (GO:0019054)2.90726215
151production of molecular mediator involved in inflammatory response (GO:0002532)2.89335438
152vitamin A metabolic process (GO:0006776)2.89104445
153GDP-mannose metabolic process (GO:0019673)2.87926998
154cellular response to interleukin-15 (GO:0071350)2.87615107
155myeloid cell activation involved in immune response (GO:0002275)2.87201096
156regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86843204
157negative regulation of leukocyte mediated immunity (GO:0002704)2.86511997
158nucleoside transport (GO:0015858)2.85278293
159negative regulation of viral release from host cell (GO:1902187)2.85126826
160leukocyte degranulation (GO:0043299)2.84712261
161regulation of leukocyte degranulation (GO:0043300)2.82600564
162regulation of mast cell activation involved in immune response (GO:0033006)2.81543393
163mitochondrion distribution (GO:0048311)2.81520477
164coenzyme catabolic process (GO:0009109)2.81087269
165pseudouridine synthesis (GO:0001522)2.80873048
166histone H3-K4 methylation (GO:0051568)2.78412748
167T cell migration (GO:0072678)2.78146504
168regulation of tolerance induction (GO:0002643)2.77305779
169regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.77016132
170DNA damage response, signal transduction resulting in transcription (GO:0042772)2.76693712
171tachykinin receptor signaling pathway (GO:0007217)2.76192278
172regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74941340
173positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74448408
174positive regulation of isotype switching (GO:0045830)2.73694514
175defense response to protozoan (GO:0042832)2.71974361
176negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70309796
177negative regulation of innate immune response (GO:0045824)2.68909537
178regulation of alpha-beta T cell proliferation (GO:0046640)2.67361679
179cellular extravasation (GO:0045123)2.65962382
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65594732
181negative regulation of T cell mediated immunity (GO:0002710)2.64831073
182modulation by symbiont of host cellular process (GO:0044068)2.64482130
183B cell mediated immunity (GO:0019724)2.62906206
184regulation of B cell differentiation (GO:0045577)2.61057182
185interferon-gamma-mediated signaling pathway (GO:0060333)2.60631496
186cellular response to virus (GO:0098586)2.60342015
187response to laminar fluid shear stress (GO:0034616)2.59969696
188positive regulation of B cell differentiation (GO:0045579)2.59487372
189regulation of interleukin-12 biosynthetic process (GO:0045075)2.59297426
190response to protozoan (GO:0001562)2.55299742
191myeloid dendritic cell differentiation (GO:0043011)2.55250957
192negative regulation of interleukin-6 production (GO:0032715)2.55049352
193antigen processing and presentation via MHC class Ib (GO:0002475)2.54857778
194regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54478047
195regulation of natural killer cell mediated immunity (GO:0002715)2.54478047
196positive regulation of Cdc42 GTPase activity (GO:0043089)2.54414164
197regulation of type 2 immune response (GO:0002828)2.54034974
198positive regulation of granulocyte differentiation (GO:0030854)2.53435947
199regulation of regulated secretory pathway (GO:1903305)2.53375738
200negative regulation of cytokine production involved in immune response (GO:0002719)2.52995815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48999945
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.47802876
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.47802876
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.47802876
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.32531328
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49413973
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.02102496
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.91299265
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.79989901
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79247292
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.73154520
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70169790
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65166428
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59580723
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.52886070
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.41805928
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32708106
18VDR_24763502_ChIP-Seq_THP-1_Human2.26670937
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24642840
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22565523
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.21923308
22MYC_22102868_ChIP-Seq_BL_Human2.18428146
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17419809
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16305608
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15215625
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14883814
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.14768956
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13682078
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12463983
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10744586
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09163787
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.99778816
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98916003
34MAF_26560356_Chip-Seq_TH2_Human1.93866334
35* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91825469
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91591147
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.91419314
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91194254
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86802391
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86475837
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77901268
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.75714676
43MYB_26560356_Chip-Seq_TH2_Human1.75600546
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75470725
45NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74855816
46SPI1_23127762_ChIP-Seq_K562_Human1.74535922
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73738598
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72300003
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71877971
50RUNX_20019798_ChIP-Seq_JUKART_Human1.69808951
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.67490782
52SPI1_23547873_ChIP-Seq_NB4_Human1.67110378
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66791780
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66312818
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65053743
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63306336
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62073901
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61781067
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.60280105
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56403097
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54358590
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53827202
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53812123
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.51687478
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51012000
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49429242
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.47721336
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46730320
69* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46622670
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46315385
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43561284
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39518425
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38699637
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38253547
75* P68_20966046_ChIP-Seq_HELA_Human1.37897412
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36843864
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.36144316
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36031620
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33709309
80IRF1_19129219_ChIP-ChIP_H3396_Human1.33677758
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.33649404
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33092307
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32960566
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32584531
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32410938
86GATA1_19941826_ChIP-Seq_K562_Human1.31226705
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30758324
88* BCL6_27268052_Chip-Seq_Bcells_Human1.30554920
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28612048
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.28440911
91* BCOR_27268052_Chip-Seq_Bcells_Human1.28358540
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.27741141
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26700859
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.25906396
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25254611
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24157192
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23630116
98* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22773832
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22561897
100KDM2B_26808549_Chip-Seq_K562_Human1.22468260
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22065644
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22033442
103* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21628146
104* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20341717
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19522724
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18331413
107SCL_19346495_ChIP-Seq_HPC-7_Human1.17639770
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17238008
109* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16468580
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14074633
111NCOR1_26117541_ChIP-Seq_K562_Human1.13527301
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13472079
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13373238
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.12231244
115* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11616409
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11373804
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11123370
118VDR_21846776_ChIP-Seq_THP-1_Human1.09729318
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09133290
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09033051
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08234607
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07934055
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.06676130
124TET1_21451524_ChIP-Seq_MESCs_Mouse1.06622203
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05805468
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05282743
127SMC4_20622854_ChIP-Seq_HELA_Human1.05183641
128E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04330557
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02240592
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00591781
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99656604
132GATA3_27048872_Chip-Seq_THYMUS_Human0.98448314
133CREB1_26743006_Chip-Seq_LNCaP_Human0.98356600
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97362284
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96397241
136TP53_22127205_ChIP-Seq_IMR90_Human0.95922483
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.95087740
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95027494
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94870645
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94392808
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93559179
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.92641957
143* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92311929
144NANOG_16518401_ChIP-PET_MESCs_Mouse0.91884250
145KDM5A_27292631_Chip-Seq_BREAST_Human0.91160000
146* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88811622
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87618974
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87311865
149CIITA_25753668_ChIP-Seq_RAJI_Human0.84662406
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84618421
151* FOXP3_21729870_ChIP-Seq_TREG_Human0.83348789
152RACK7_27058665_Chip-Seq_MCF-7_Human0.82943843
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82612264
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82589891
155NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82018918
156* XRN2_22483619_ChIP-Seq_HELA_Human0.81866121
157STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81147964
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79640230
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79484228
160KAP1_27257070_Chip-Seq_ESCs_Mouse0.78877551
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78201963
162KDM2B_26808549_Chip-Seq_DND41_Human0.78185943
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.78136686
164CTCF_21964334_Chip-Seq_Bcells_Human0.77867592
165MAF_26560356_Chip-Seq_TH1_Human0.77112379
166PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76344606
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76332309
168MYB_26560356_Chip-Seq_TH1_Human0.75998174
169DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75384155
170* LXR_22292898_ChIP-Seq_THP-1_Human0.74781228
171* NANOG_16153702_ChIP-ChIP_HESCs_Human0.74694060
172UTX_26944678_Chip-Seq_JUKART_Human0.74285902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.99361588
2MP0004264_abnormal_extraembryonic_tissu3.99224438
3MP0003436_decreased_susceptibility_to3.89338854
4MP0003303_peritoneal_inflammation3.73824291
5MP0006292_abnormal_olfactory_placode3.62781509
6MP0002254_reproductive_system_inflammat3.58121618
7MP0003011_delayed_dark_adaptation3.52673071
8MP0003724_increased_susceptibility_to3.21340481
9MP0001835_abnormal_antigen_presentation3.13999876
10MP0004957_abnormal_blastocyst_morpholog3.12985245
11MP0003890_abnormal_embryonic-extraembry3.12951555
12MP0005075_abnormal_melanosome_morpholog3.03456489
13MP0005671_abnormal_response_to2.89553516
14MP0005000_abnormal_immune_tolerance2.74199068
15MP0005387_immune_system_phenotype2.67725849
16MP0001790_abnormal_immune_system2.67725849
17MP0001800_abnormal_humoral_immune2.66516110
18MP0010352_gastrointestinal_tract_polyps2.60795385
19MP0005394_taste/olfaction_phenotype2.57926560
20MP0005499_abnormal_olfactory_system2.57926560
21MP0000685_abnormal_immune_system2.46589685
22MP0002332_abnormal_exercise_endurance2.43716874
23MP0005025_abnormal_response_to2.43678613
24MP0005451_abnormal_body_composition2.42228164
25MP0002419_abnormal_innate_immunity2.40701643
26MP0002653_abnormal_ependyma_morphology2.38212721
27MP0002723_abnormal_immune_serum2.37798885
28MP0009333_abnormal_splenocyte_physiolog2.37493472
29MP0004858_abnormal_nervous_system2.32571185
30MP0005464_abnormal_platelet_physiology2.31588763
31MP0009278_abnormal_bone_marrow2.29914238
32MP0002452_abnormal_antigen_presenting2.28085570
33MP0003705_abnormal_hypodermis_morpholog2.26868214
34MP0002420_abnormal_adaptive_immunity2.26693804
35MP0001819_abnormal_immune_cell2.24586959
36MP0009785_altered_susceptibility_to2.24257292
37MP0003122_maternal_imprinting2.19039348
38MP0008260_abnormal_autophagy2.09027598
39MP0003077_abnormal_cell_cycle2.07648273
40MP0002148_abnormal_hypersensitivity_rea2.03545222
41MP0004947_skin_inflammation2.01736396
42MP0003121_genomic_imprinting1.93445915
43MP0004510_myositis1.92756419
44MP0003300_gastrointestinal_ulcer1.91636258
45* MP0001672_abnormal_embryogenesis/_devel1.90134339
46* MP0005380_embryogenesis_phenotype1.90134339
47MP0003111_abnormal_nucleus_morphology1.88796968
48MP0002877_abnormal_melanocyte_morpholog1.86643547
49MP0000716_abnormal_immune_system1.86462759
50MP0005257_abnormal_intraocular_pressure1.86360575
51MP0001533_abnormal_skeleton_physiology1.86342482
52MP0000678_abnormal_parathyroid_gland1.82928425
53MP0002396_abnormal_hematopoietic_system1.81954416
54* MP0002088_abnormal_embryonic_growth/wei1.76129544
55MP0006082_CNS_inflammation1.75884840
56MP0003172_abnormal_lysosome_physiology1.75169301
57* MP0003984_embryonic_growth_retardation1.74973272
58MP0010094_abnormal_chromosome_stability1.73737208
59MP0010155_abnormal_intestine_physiology1.73104622
60MP0005058_abnormal_lysosome_morphology1.69000529
61MP0001873_stomach_inflammation1.68256150
62* MP0000350_abnormal_cell_proliferation1.65951628
63MP0008961_abnormal_basal_metabolism1.63171208
64MP0006035_abnormal_mitochondrial_morpho1.62682983
65MP0010030_abnormal_orbit_morphology1.60035262
66MP0002086_abnormal_extraembryonic_tissu1.56145872
67MP0003191_abnormal_cellular_cholesterol1.55335252
68MP0001849_ear_inflammation1.53177731
69MP0001293_anophthalmia1.51925263
70MP0002277_abnormal_respiratory_mucosa1.45829885
71MP0003938_abnormal_ear_development1.45749744
72MP0002127_abnormal_cardiovascular_syste1.45268227
73MP0002085_abnormal_embryonic_tissue1.43803194
74MP0001845_abnormal_inflammatory_respons1.43578055
75MP0000490_abnormal_crypts_of1.42517197
76MP0003183_abnormal_peptide_metabolism1.35195743
77MP0005310_abnormal_salivary_gland1.33862965
78MP0003693_abnormal_embryo_hatching1.31695473
79MP0002084_abnormal_developmental_patter1.29584216
80MP0008007_abnormal_cellular_replicative1.28286837
81MP0003866_abnormal_defecation1.27373559
82MP0002092_abnormal_eye_morphology1.25868362
83MP0008004_abnormal_stomach_pH1.25257444
84MP0002932_abnormal_joint_morphology1.24926013
85MP0000465_gastrointestinal_hemorrhage1.24911251
86MP0003123_paternal_imprinting1.24713773
87MP0001730_embryonic_growth_arrest1.24517887
88MP0003656_abnormal_erythrocyte_physiolo1.21510523
89MP0008469_abnormal_protein_level1.21101015
90MP0001853_heart_inflammation1.20528915
91MP0000313_abnormal_cell_death1.19516389
92MP0002998_abnormal_bone_remodeling1.18073829
93MP0001697_abnormal_embryo_size1.17081290
94MP0004808_abnormal_hematopoietic_stem1.15187308
95MP0005266_abnormal_metabolism1.14533848
96MP0002166_altered_tumor_susceptibility1.13857674
97MP0001851_eye_inflammation1.12231574
98MP0002138_abnormal_hepatobiliary_system1.11192651
99MP0002132_abnormal_respiratory_system1.11171461
100MP0004133_heterotaxia1.11000806
101MP0000049_abnormal_middle_ear1.10998448
102MP0003075_altered_response_to1.09791910
103MP0003119_abnormal_digestive_system1.07290980
104MP0008932_abnormal_embryonic_tissue1.05976118
105MP0009840_abnormal_foam_cell1.05190577
106MP0008789_abnormal_olfactory_epithelium1.01802990
107MP0002970_abnormal_white_adipose1.01672580
108* MP0002080_prenatal_lethality1.01018995
109MP0009764_decreased_sensitivity_to0.99695723
110MP0001348_abnormal_lacrimal_gland0.99273528
111MP0003453_abnormal_keratinocyte_physiol0.98078639
112MP0002925_abnormal_cardiovascular_devel0.97083121
113MP0000762_abnormal_tongue_morphology0.96968410
114MP0008770_decreased_survivor_rate0.96450372
115MP0000432_abnormal_head_morphology0.95822629
116* MP0004197_abnormal_fetal_growth/weight/0.95684158
117MP0005166_decreased_susceptibility_to0.94506873
118MP0005023_abnormal_wound_healing0.94058868
119MP0002019_abnormal_tumor_incidence0.93771996
120MP0002114_abnormal_axial_skeleton0.93700058
121MP0000428_abnormal_craniofacial_morphol0.92373490
122MP0002722_abnormal_immune_system0.92055468
123MP0003935_abnormal_craniofacial_develop0.91432345
124MP0000689_abnormal_spleen_morphology0.91328248
125MP0003828_pulmonary_edema0.90617648
126MP0002933_joint_inflammation0.89583069
127MP0001663_abnormal_digestive_system0.88876069
128MP0003448_altered_tumor_morphology0.86622591
129MP0000858_altered_metastatic_potential0.85850895
130MP0003091_abnormal_cell_migration0.85714131
131MP0005390_skeleton_phenotype0.85200169
132MP0002405_respiratory_system_inflammati0.83686778
133MP0003786_premature_aging0.83369730
134MP0005083_abnormal_biliary_tract0.83131343
135MP0002398_abnormal_bone_marrow0.81242317
136MP0000703_abnormal_thymus_morphology0.80046937
137MP0004883_abnormal_blood_vessel0.79906923
138MP0000750_abnormal_muscle_regeneration0.79054823
139MP0005076_abnormal_cell_differentiation0.78968181
140MP0003755_abnormal_palate_morphology0.78737099
141MP0002233_abnormal_nose_morphology0.78126348
142MP0008058_abnormal_DNA_repair0.77907846
143MP0000343_altered_response_to0.77633617
144MP0009703_decreased_birth_body0.77561368
145MP0003566_abnormal_cell_adhesion0.76859751
146MP0003283_abnormal_digestive_organ0.76108911
147MP0005666_abnormal_adipose_tissue0.74531664
148MP0005248_abnormal_Harderian_gland0.74160128
149MP0005508_abnormal_skeleton_morphology0.73428459
150MP0003787_abnormal_imprinting0.73229746
151MP0005391_vision/eye_phenotype0.71463723
152MP0002009_preneoplasia0.71406472
153MP0002429_abnormal_blood_cell0.70999393
154MP0004381_abnormal_hair_follicle0.70384632
155MP0009115_abnormal_fat_cell0.70273012
156MP0000249_abnormal_blood_vessel0.69972443
157MP0003045_fibrosis0.69911972
158MP0004185_abnormal_adipocyte_glucose0.69552888
159MP0002269_muscular_atrophy0.69339903
160MP0009763_increased_sensitivity_to0.68920541
161MP0003763_abnormal_thymus_physiology0.68334826
162MP0003795_abnormal_bone_structure0.67954345
163MP0002006_tumorigenesis0.67028788
164MP0001545_abnormal_hematopoietic_system0.66590407
165MP0005397_hematopoietic_system_phenotyp0.66590407
166MP0001286_abnormal_eye_development0.66271230
167MP0002116_abnormal_craniofacial_bone0.65427955
168MP0002249_abnormal_larynx_morphology0.64777490
169MP0003137_abnormal_impulse_conducting0.64524066
170MP0005621_abnormal_cell_physiology0.63833518
171MP0005381_digestive/alimentary_phenotyp0.63607409
172MP0000015_abnormal_ear_pigmentation0.62998507
173MP0000609_abnormal_liver_physiology0.61518075
174MP0005375_adipose_tissue_phenotype0.60707481

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.74336931
2Hypochromic microcytic anemia (HP:0004840)6.14060301
3Eczematoid dermatitis (HP:0000976)5.05197848
4Rib fusion (HP:0000902)4.90631023
5Hepatoblastoma (HP:0002884)4.82910559
6Multiple enchondromatosis (HP:0005701)4.81583572
7Abnormality of the lower motor neuron (HP:0002366)4.41338069
8Ependymoma (HP:0002888)4.38234756
9Abnormality of macrophages (HP:0004311)4.10347498
10Stomatitis (HP:0010280)3.89303566
11Myositis (HP:0100614)3.85105929
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84518594
13Neoplasm of striated muscle (HP:0009728)3.81828647
14Prolonged bleeding time (HP:0003010)3.77637565
15Recurrent abscess formation (HP:0002722)3.73508056
16Rhabdomyosarcoma (HP:0002859)3.67914052
17Orchitis (HP:0100796)3.65416175
18Recurrent bacterial skin infections (HP:0005406)3.64527216
19Nephroblastoma (Wilms tumor) (HP:0002667)3.62232572
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.57007560
21Increased IgE level (HP:0003212)3.53058200
22Meningitis (HP:0001287)3.46190080
23Obstructive lung disease (HP:0006536)3.42483928
24Chronic obstructive pulmonary disease (HP:0006510)3.42483928
25Rectal fistula (HP:0100590)3.42071550
26Rectovaginal fistula (HP:0000143)3.42071550
27Petechiae (HP:0000967)3.41920158
28Chromsome breakage (HP:0040012)3.37615456
29Optic neuritis (HP:0100653)3.37174153
30Retrobulbar optic neuritis (HP:0100654)3.37174153
31Embryonal renal neoplasm (HP:0011794)3.34418679
32Elevated erythrocyte sedimentation rate (HP:0003565)3.33467463
33Mediastinal lymphadenopathy (HP:0100721)3.30406356
34Intestinal fistula (HP:0100819)3.28414198
35Cellulitis (HP:0100658)3.21256985
36Recurrent fungal infections (HP:0002841)3.21227109
37Testicular atrophy (HP:0000029)3.14893378
38Fused cervical vertebrae (HP:0002949)3.11659462
39Hypochromic anemia (HP:0001931)3.10548472
40Abnormality of the astrocytes (HP:0100707)3.06905066
41Astrocytoma (HP:0009592)3.06905066
42Gastrointestinal infarctions (HP:0005244)3.03550367
43Spontaneous hematomas (HP:0007420)2.98590151
44Hypoplasia of the fovea (HP:0007750)2.98031348
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.98031348
46Aplasia/hypoplasia of the humerus (HP:0006507)2.97025150
47Chest pain (HP:0100749)2.95053761
48Epistaxis (HP:0000421)2.93784864
49Short humerus (HP:0005792)2.92257688
50Vaginal fistula (HP:0004320)2.91555794
51Vasculitis (HP:0002633)2.90204192
52Pulmonary infiltrates (HP:0002113)2.85919320
53Abnormality of the salivary glands (HP:0010286)2.85515345
54Partial duplication of thumb phalanx (HP:0009944)2.85311792
55Trismus (HP:0000211)2.81832085
56Gingivitis (HP:0000230)2.81580560
57Abnormal lung lobation (HP:0002101)2.77528624
58Purpura (HP:0000979)2.77408003
59Amyotrophic lateral sclerosis (HP:0007354)2.75201477
60Obstructive sleep apnea (HP:0002870)2.72959694
61Increased IgM level (HP:0003496)2.72304057
62Abnormality of the fingertips (HP:0001211)2.71768066
63Encephalitis (HP:0002383)2.71520329
64Pustule (HP:0200039)2.67541213
65Ragged-red muscle fibers (HP:0003200)2.63149951
66Meckel diverticulum (HP:0002245)2.62674236
67Gastrointestinal inflammation (HP:0004386)2.62617275
68Recurrent gram-negative bacterial infections (HP:0005420)2.62345047
69Recurrent viral infections (HP:0004429)2.61826046
70Preauricular skin tag (HP:0000384)2.58787718
71Keratoconjunctivitis sicca (HP:0001097)2.58122557
72Abnormality of the ileum (HP:0001549)2.56142392
73Agammaglobulinemia (HP:0004432)2.55574447
74Gastrointestinal stroma tumor (HP:0100723)2.52299431
75Impulsivity (HP:0100710)2.52237217
76Urticaria (HP:0001025)2.51889052
77Gingival bleeding (HP:0000225)2.51339377
78Partial duplication of the phalanx of hand (HP:0009999)2.50161758
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.50069849
80Abnormality of chromosome segregation (HP:0002916)2.46598124
81Combined immunodeficiency (HP:0005387)2.45546182
82Inflammation of the large intestine (HP:0002037)2.44737659
83Short 5th finger (HP:0009237)2.44732497
84Shawl scrotum (HP:0000049)2.43170578
85Large earlobe (HP:0009748)2.42689979
86Recurrent skin infections (HP:0001581)2.42226999
87Hyperinsulinemic hypoglycemia (HP:0000825)2.41887443
88Abnormal platelet volume (HP:0011876)2.41866974
89Anomalous pulmonary venous return (HP:0010772)2.41565900
90Tongue fasciculations (HP:0001308)2.40303946
91Skin tags (HP:0010609)2.39180054
92Horizontal nystagmus (HP:0000666)2.37529115
93Bifid tongue (HP:0010297)2.36888226
94Reduced antithrombin III activity (HP:0001976)2.33422032
95Increased serum ferritin (HP:0003281)2.32877541
96Panhypogammaglobulinemia (HP:0003139)2.32010467
97Arterial thrombosis (HP:0004420)2.31400627
98Keratoconjunctivitis (HP:0001096)2.28676570
99Supernumerary spleens (HP:0009799)2.28135764
100Abnormality of T cells (HP:0002843)2.28061826
101Granulocytopenia (HP:0001913)2.27848117
102Glioma (HP:0009733)2.27642780
103Abnormality of the heme biosynthetic pathway (HP:0010472)2.27248482
104Hypertensive crisis (HP:0100735)2.27113475
105Abnormal cartilage morphology (HP:0002763)2.26468776
106Recurrent cutaneous fungal infections (HP:0011370)2.24896557
107Chronic mucocutaneous candidiasis (HP:0002728)2.24896557
108Generalized hypotonia (HP:0001290)2.23495848
109Polycythemia (HP:0001901)2.22405951
110Osteomyelitis (HP:0002754)2.22296441
111Emphysema (HP:0002097)2.22150805
112Preauricular pit (HP:0004467)2.21447318
113Periauricular skin pits (HP:0100277)2.21447318
114Episodic fever (HP:0001954)2.21386655
115Abnormality of T cell physiology (HP:0011840)2.21271520
116Muscle fibrillation (HP:0010546)2.21269693
117Lymphopenia (HP:0001888)2.19852724
118Abnormality of the fovea (HP:0000493)2.19386708
119Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19134411
120Nasal polyposis (HP:0100582)2.17964746
121Cheilitis (HP:0100825)2.17053082
122Sepsis (HP:0100806)2.16729494
123Dysostosis multiplex (HP:0000943)2.16611653
124Restrictive lung disease (HP:0002091)2.14867524
125Hepatosplenomegaly (HP:0001433)2.14718929
126Duodenal stenosis (HP:0100867)2.12442497
127Small intestinal stenosis (HP:0012848)2.12442497
128T lymphocytopenia (HP:0005403)2.11656325
129Progressive muscle weakness (HP:0003323)2.11342892
130Pseudobulbar signs (HP:0002200)2.11155744
131Peripheral hypomyelination (HP:0007182)2.10933018
132Vertebral fusion (HP:0002948)2.10503800
133Papilloma (HP:0012740)2.10096945
134Verrucae (HP:0200043)2.10096945
135Hemoptysis (HP:0002105)2.09788880
136Slow saccadic eye movements (HP:0000514)2.08967611
137Alveolar cell carcinoma (HP:0006519)2.08516267
138Abnormality of the phalanges of the hallux (HP:0010057)2.07951986
139Broad face (HP:0000283)2.07609745
140Hypergammaglobulinemia (HP:0010702)2.07586725
141Leukocytosis (HP:0001974)2.07248917
142Medulloblastoma (HP:0002885)2.06767066
143Abnormality of the musculature of the hand (HP:0001421)2.06716056
144Increased connective tissue (HP:0009025)2.06214946
145Colitis (HP:0002583)2.06143847
146Neoplasm of the heart (HP:0100544)2.05888004
147Aplasia/Hypoplasia of the sternum (HP:0006714)2.05132777
148Abnormality of cells of the lymphoid lineage (HP:0012140)2.04570736
149Abnormality of the pulmonary veins (HP:0011718)2.03846153
150Pendular nystagmus (HP:0012043)2.03698947
151Centrally nucleated skeletal muscle fibers (HP:0003687)2.03167299
152Abnormality of the distal phalanx of the thumb (HP:0009617)2.02115371
153Fatigue (HP:0012378)2.01947548
154Atrophy/Degeneration involving motor neurons (HP:0007373)2.01010283
155Increased cerebral lipofuscin (HP:0011813)2.00853832
156Loss of speech (HP:0002371)1.99963613
157Villous atrophy (HP:0011473)1.99414539
158Abnormality of small intestinal villus morphology (HP:0011472)1.99414539
159Anorexia (HP:0002039)1.98817495
160Difficulty running (HP:0009046)1.98616777
161Menorrhagia (HP:0000132)1.98131418
162Joint swelling (HP:0001386)1.97671569
163Malignant neoplasm of the central nervous system (HP:0100836)1.94831796
164Easy fatigability (HP:0003388)1.94762667
165Abnormality of iron homeostasis (HP:0011031)1.94717496
166Renal duplication (HP:0000075)1.93985758
167Segmental peripheral demyelination/remyelination (HP:0003481)1.93023376
168Selective tooth agenesis (HP:0001592)1.91385306
169Hand muscle atrophy (HP:0009130)1.91113642
170Glossoptosis (HP:0000162)1.91050132
171Abnormality of T cell number (HP:0011839)1.90781967
172Supernumerary ribs (HP:0005815)1.90638423
173Aplasia/Hypoplasia of the macula (HP:0008059)1.90410103
174Abnormality of the pleura (HP:0002103)1.89807549
175Abnormality of liposaccharide metabolism (HP:0010968)1.89316983
176Abnormality of glycosphingolipid metabolism (HP:0004343)1.89316983
177Abnormality of glycolipid metabolism (HP:0010969)1.89316983
178Hypertriglyceridemia (HP:0002155)1.87171754
179Myelodysplasia (HP:0002863)1.86394722
180Abnormality of the pubic bones (HP:0003172)1.86092707
181Cholecystitis (HP:0001082)1.85136357
182Abnormal gallbladder physiology (HP:0012438)1.85136357
183Progressive neurologic deterioration (HP:0002344)1.85035093
184Abnormality of the columella (HP:0009929)1.84675801
185Abnormality of skeletal muscle fiber size (HP:0012084)1.84591516
186Nasolacrimal duct obstruction (HP:0000579)1.84569783
187Premature ovarian failure (HP:0008209)1.84354387
188Fasciculations (HP:0002380)1.84103521
189Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83697869
190Neoplasm of the tracheobronchial system (HP:0100552)1.83063300
191Skin pits (HP:0100276)1.82007959
192Spinal muscular atrophy (HP:0007269)1.81448955
193Abnormality of the nasal mucosa (HP:0000433)1.81327689
194Upper motor neuron abnormality (HP:0002127)1.80639828
195Hypopigmentation of the fundus (HP:0007894)1.79990315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.50569230
2ERN14.56490393
3GRK54.32405472
4GRK64.09452078
5RIPK43.32288579
6CSF1R2.74099191
7STK102.73969463
8TGFBR22.59397240
9ADRBK22.57425545
10GRK12.57386018
11TYRO32.56558324
12TTK2.49994738
13MAP2K32.44960897
14SIK32.35861799
15MATK2.25040145
16MAP3K102.20911113
17MAPK72.20283081
18GRK72.13148366
19IRAK42.12733683
20TYK21.99606676
21SMG11.98945433
22MAP3K31.89695985
23EPHB11.86202330
24IRAK31.85229383
25CDK71.83361454
26TNK21.80126430
27MOS1.72505224
28MAP3K111.72061479
29TXK1.58491891
30WNK11.57269161
31MAP3K141.51412090
32JAK31.44854392
33TBK11.44645755
34IKBKE1.41528917
35BTK1.38715068
36PAK41.35832629
37CHEK21.35190671
38FES1.33884218
39HIPK21.33544919
40PRKG21.31199351
41CAMK41.30520319
42MAP3K11.27796678
43PLK11.19066340
44EPHA21.16755819
45MARK21.14918357
46TESK11.13460194
47SYK1.11722914
48CDC71.08915717
49CSK1.08403431
50FGFR31.02938641
51MAP3K131.02279694
52MARK31.02054025
53NEK21.01810018
54IRAK21.00879218
55CDC42BPA0.98759359
56AKT30.97424221
57FGFR40.95776290
58CHEK10.87150740
59ALK0.86840962
60JAK10.85297185
61KSR20.84941037
62NTRK10.82943344
63CAMK1D0.82560928
64LYN0.82012647
65MAP4K10.80701793
66IRAK10.77715629
67PTK60.77678198
68PDPK10.77604333
69LRRK20.76745372
70PDK10.76690498
71ICK0.76114211
72JAK20.75967246
73ADRBK10.75926903
74CDK40.75102366
75LCK0.73530176
76BUB10.69735709
77MAP3K50.69590099
78MTOR0.68562219
79AKT20.67295687
80FGR0.65809383
81RPS6KC10.63304080
82RPS6KL10.63304080
83PRKD30.63018121
84IKBKB0.61986305
85TTN0.61426260
86CDK20.58508214
87RPS6KB20.58493103
88PRKD20.57525990
89NME20.56896127
90MAP2K60.56652417
91WEE10.56360024
92STK40.55098901
93EIF2AK20.55093820
94MAPK120.54492605
95ITK0.53863210
96PIM10.53506326
97BLK0.52686867
98BMX0.52365403
99TAOK30.50930454
100MAP3K70.50874830
101AURKB0.49225971
102DYRK30.48922615
103RPS6KA20.47839375
104MAPK110.47028768
105AURKA0.45454142
106ATM0.44781292
107RPS6KA60.44577115
108TESK20.44404808
109CHUK0.43993596
110LATS20.43340539
111STK380.43265126
112ARAF0.42119003
113PDGFRA0.41686326
114MAP2K40.40587633
115PKN20.39585710
116MAP3K60.38656361
117MAP2K20.38428185
118TAOK10.37980197
119DYRK1B0.36969798
120SGK30.36949778
121PIM20.36696888
122TEC0.36281766
123FYN0.36224137
124SIK20.36199122
125TAOK20.35475547
126CDK90.35370877
127PAK10.34674661
128BRD40.33712473
129PRKCI0.33562891
130MAP3K80.32438243
131PTK20.32054586
132DDR20.31702387
133MAPK10.30228665
134CDK10.29631614
135ATR0.28827933
136PRPF4B0.28617770
137PRKCD0.27876632
138MAPKAPK20.25341853
139TRIB30.25243032
140MAPK100.24652020
141MAPK140.24470534
142MAPKAPK30.24249087
143NEK10.22784045
144IGF1R0.21577635
145ERBB20.20577600
146ZAP700.20548384
147MAPK40.20405629
148GSK3B0.20212304
149CDK80.19164293
150CSNK1E0.19123665
151PRKAA10.18948668
152INSR0.18688329
153GSK3A0.17934247
154CDK60.17933348
155RIPK10.17059314
156HCK0.16618046
157SIK10.15884975
158YES10.15384151

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.85952304
2Vitamin B6 metabolism_Homo sapiens_hsa007504.62082373
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90540705
4Fructose and mannose metabolism_Homo sapiens_hsa000512.92440518
5Osteoclast differentiation_Homo sapiens_hsa043802.57847607
6DNA replication_Homo sapiens_hsa030302.50051550
7Mismatch repair_Homo sapiens_hsa034302.15631315
8RNA transport_Homo sapiens_hsa030132.12218888
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08660260
10Galactose metabolism_Homo sapiens_hsa000522.07160934
11Allograft rejection_Homo sapiens_hsa053301.92667853
12Arachidonic acid metabolism_Homo sapiens_hsa005901.90231002
13Fanconi anemia pathway_Homo sapiens_hsa034601.86563707
14Cell cycle_Homo sapiens_hsa041101.86379170
15Graft-versus-host disease_Homo sapiens_hsa053321.86336365
16Base excision repair_Homo sapiens_hsa034101.84526381
17mRNA surveillance pathway_Homo sapiens_hsa030151.81397295
18Autoimmune thyroid disease_Homo sapiens_hsa053201.71144958
19Thyroid cancer_Homo sapiens_hsa052161.71022781
20Malaria_Homo sapiens_hsa051441.68678322
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68145367
22Tuberculosis_Homo sapiens_hsa051521.68006485
23Homologous recombination_Homo sapiens_hsa034401.65309890
24mTOR signaling pathway_Homo sapiens_hsa041501.63373147
25Spliceosome_Homo sapiens_hsa030401.59052145
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52951947
27TNF signaling pathway_Homo sapiens_hsa046681.52564552
28Staphylococcus aureus infection_Homo sapiens_hsa051501.49390217
29Viral myocarditis_Homo sapiens_hsa054161.47927854
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41163427
31Chemokine signaling pathway_Homo sapiens_hsa040621.40276902
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39705961
33One carbon pool by folate_Homo sapiens_hsa006701.37916497
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37802694
35p53 signaling pathway_Homo sapiens_hsa041151.36706863
36RNA degradation_Homo sapiens_hsa030181.34257755
37Primary immunodeficiency_Homo sapiens_hsa053401.31662636
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30685794
39Ribosome_Homo sapiens_hsa030101.30374200
40Hepatitis C_Homo sapiens_hsa051601.29778312
41Linoleic acid metabolism_Homo sapiens_hsa005911.27291764
42Acute myeloid leukemia_Homo sapiens_hsa052211.27103436
43Shigellosis_Homo sapiens_hsa051311.24605311
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23467617
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22672058
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19716691
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18876033
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18115171
49Type I diabetes mellitus_Homo sapiens_hsa049401.17766031
50Herpes simplex infection_Homo sapiens_hsa051681.17232621
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14909865
52Epstein-Barr virus infection_Homo sapiens_hsa051691.09798079
53Salmonella infection_Homo sapiens_hsa051321.09782780
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09215145
55Platelet activation_Homo sapiens_hsa046111.07571217
56Notch signaling pathway_Homo sapiens_hsa043301.07171461
57Renal cell carcinoma_Homo sapiens_hsa052111.06867806
58MicroRNAs in cancer_Homo sapiens_hsa052061.06531805
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00535181
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.00306112
61Other glycan degradation_Homo sapiens_hsa005110.98395020
62Endocytosis_Homo sapiens_hsa041440.97291386
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96907264
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96194399
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92659244
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.91568413
67Endometrial cancer_Homo sapiens_hsa052130.91023290
68Pertussis_Homo sapiens_hsa051330.87913166
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87090018
70Basal cell carcinoma_Homo sapiens_hsa052170.86440920
71Pathways in cancer_Homo sapiens_hsa052000.85083881
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84885751
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.84719894
74Nucleotide excision repair_Homo sapiens_hsa034200.84401078
75FoxO signaling pathway_Homo sapiens_hsa040680.84294146
76Apoptosis_Homo sapiens_hsa042100.82745036
77Non-small cell lung cancer_Homo sapiens_hsa052230.82540176
78Rheumatoid arthritis_Homo sapiens_hsa053230.82358153
79Prolactin signaling pathway_Homo sapiens_hsa049170.80221169
80Phagosome_Homo sapiens_hsa041450.78217115
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78169720
82Bladder cancer_Homo sapiens_hsa052190.77702830
83Prostate cancer_Homo sapiens_hsa052150.77428974
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.77371538
85B cell receptor signaling pathway_Homo sapiens_hsa046620.76758943
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75758555
87Insulin signaling pathway_Homo sapiens_hsa049100.75655206
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74946131
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74504026
90Asthma_Homo sapiens_hsa053100.73692931
91HTLV-I infection_Homo sapiens_hsa051660.73119913
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.71145585
93Lysosome_Homo sapiens_hsa041420.71015427
94RNA polymerase_Homo sapiens_hsa030200.70461158
95Viral carcinogenesis_Homo sapiens_hsa052030.69652859
96Insulin resistance_Homo sapiens_hsa049310.69624784
97Hippo signaling pathway_Homo sapiens_hsa043900.69152763
98T cell receptor signaling pathway_Homo sapiens_hsa046600.68971475
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68642746
100Inositol phosphate metabolism_Homo sapiens_hsa005620.68363874
101Pancreatic cancer_Homo sapiens_hsa052120.68108149
102Leishmaniasis_Homo sapiens_hsa051400.68037434
103Basal transcription factors_Homo sapiens_hsa030220.67563207
104Hedgehog signaling pathway_Homo sapiens_hsa043400.67367798
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.66829461
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.66771933
107Non-homologous end-joining_Homo sapiens_hsa034500.66501902
108Choline metabolism in cancer_Homo sapiens_hsa052310.65154164
109Small cell lung cancer_Homo sapiens_hsa052220.64730928
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64532671
111Sulfur relay system_Homo sapiens_hsa041220.64221864
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.62691009
113Adherens junction_Homo sapiens_hsa045200.61411303
114VEGF signaling pathway_Homo sapiens_hsa043700.61140261
115HIF-1 signaling pathway_Homo sapiens_hsa040660.60180138
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59274541
117Colorectal cancer_Homo sapiens_hsa052100.59133428
118MAPK signaling pathway_Homo sapiens_hsa040100.58227653
119Pentose phosphate pathway_Homo sapiens_hsa000300.56352944
120GnRH signaling pathway_Homo sapiens_hsa049120.56098105
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55616791
122ErbB signaling pathway_Homo sapiens_hsa040120.55499580
123Amoebiasis_Homo sapiens_hsa051460.54559328
124Glioma_Homo sapiens_hsa052140.53047899
125Rap1 signaling pathway_Homo sapiens_hsa040150.51851489
126Folate biosynthesis_Homo sapiens_hsa007900.51203525
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50847121
128Proteoglycans in cancer_Homo sapiens_hsa052050.50083514
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48885954
130Wnt signaling pathway_Homo sapiens_hsa043100.46632992
131Antigen processing and presentation_Homo sapiens_hsa046120.46407529
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.46378768
133Influenza A_Homo sapiens_hsa051640.46302789
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46143287
135Chronic myeloid leukemia_Homo sapiens_hsa052200.45675605
136AMPK signaling pathway_Homo sapiens_hsa041520.42885098
137Lysine degradation_Homo sapiens_hsa003100.42490902
138Pyrimidine metabolism_Homo sapiens_hsa002400.41978099
139Measles_Homo sapiens_hsa051620.41689580
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41613130
141Prion diseases_Homo sapiens_hsa050200.40047294
142Hematopoietic cell lineage_Homo sapiens_hsa046400.39311477
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38064839
144Legionellosis_Homo sapiens_hsa051340.37993661
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.36519951
146African trypanosomiasis_Homo sapiens_hsa051430.35029972
147Ether lipid metabolism_Homo sapiens_hsa005650.33032113
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30998955
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30279957
150Hepatitis B_Homo sapiens_hsa051610.29526772
151Toxoplasmosis_Homo sapiens_hsa051450.28983031
152Ovarian steroidogenesis_Homo sapiens_hsa049130.25723180

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