SP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24961247
2nuclear pore complex assembly (GO:0051292)4.20618192
3mitotic sister chromatid cohesion (GO:0007064)4.11770759
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86630632
5nuclear pore organization (GO:0006999)3.86596115
6positive regulation of gamma-delta T cell activation (GO:0046645)3.79944427
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.74464319
8detection of molecule of bacterial origin (GO:0032490)3.70898745
9mitotic chromosome condensation (GO:0007076)3.63353237
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58928830
11DNA unwinding involved in DNA replication (GO:0006268)3.44636979
12DNA topological change (GO:0006265)3.32443376
13dosage compensation (GO:0007549)3.31999131
14regulation of RNA export from nucleus (GO:0046831)3.29374002
15positive regulation by symbiont of host defense response (GO:0052509)3.25610163
16modulation by symbiont of host defense response (GO:0052031)3.25610163
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25610163
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25610163
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.25610163
20modulation by symbiont of host immune response (GO:0052553)3.25610163
21negative regulation of DNA repair (GO:0045738)3.23597520
22hepatocyte apoptotic process (GO:0097284)3.19054129
23regulation of histone H3-K9 methylation (GO:0051570)3.18865394
24pore complex assembly (GO:0046931)3.17813583
25negative regulation of histone methylation (GO:0031061)3.17323073
26regulation of gamma-delta T cell differentiation (GO:0045586)3.17252371
27regulation of histone H3-K27 methylation (GO:0061085)3.14093312
28cellular response to ethanol (GO:0071361)3.12828754
29negative regulation of fibroblast apoptotic process (GO:2000270)3.11958723
30regulation of DNA endoreduplication (GO:0032875)3.11258252
31regulation of sister chromatid cohesion (GO:0007063)3.11123833
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05914736
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05914736
34detection of other organism (GO:0098543)2.98914038
35cellular extravasation (GO:0045123)2.96848346
36protein localization to kinetochore (GO:0034501)2.93403515
37histone H3-K4 trimethylation (GO:0080182)2.89487656
38regulation of gamma-delta T cell activation (GO:0046643)2.89460534
39detection of external biotic stimulus (GO:0098581)2.89430769
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87992309
41DNA duplex unwinding (GO:0032508)2.87937646
42DNA geometric change (GO:0032392)2.87394170
43histone mRNA catabolic process (GO:0071044)2.86263753
44antigen processing and presentation of endogenous antigen (GO:0019883)2.82242394
45mitotic nuclear envelope disassembly (GO:0007077)2.81287203
46protein localization to chromosome, centromeric region (GO:0071459)2.81124628
47response to peptidoglycan (GO:0032494)2.81015231
48germ cell migration (GO:0008354)2.80556300
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80270538
50sister chromatid segregation (GO:0000819)2.75528130
51negative T cell selection (GO:0043383)2.74141025
52response to muramyl dipeptide (GO:0032495)2.73546821
53positive regulation of mitotic sister chromatid separation (GO:1901970)2.72634592
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72634592
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72634592
56peptidyl-lysine trimethylation (GO:0018023)2.72306768
57positive thymic T cell selection (GO:0045059)2.71841086
58chromatin assembly (GO:0031497)2.70726091
59positive regulation of granulocyte differentiation (GO:0030854)2.70051244
60regulation of fibroblast apoptotic process (GO:2000269)2.67859889
61positive regulation of histone deacetylation (GO:0031065)2.67148345
62membrane disassembly (GO:0030397)2.65885064
63nuclear envelope disassembly (GO:0051081)2.65885064
64neutrophil mediated immunity (GO:0002446)2.65340880
65negative thymic T cell selection (GO:0045060)2.64645419
66histone H3-K9 demethylation (GO:0033169)2.64049812
67V(D)J recombination (GO:0033151)2.61168229
68* definitive hemopoiesis (GO:0060216)2.59354058
69detection of biotic stimulus (GO:0009595)2.59321060
70regulation of nucleobase-containing compound transport (GO:0032239)2.59101168
71mRNA stabilization (GO:0048255)2.58550723
72RNA stabilization (GO:0043489)2.58550723
73response to laminar fluid shear stress (GO:0034616)2.57757814
74regulation of interferon-beta biosynthetic process (GO:0045357)2.56191118
75macrophage activation involved in immune response (GO:0002281)2.54683290
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53956279
77negative regulation of cell killing (GO:0031342)2.53956279
78monoubiquitinated protein deubiquitination (GO:0035520)2.53047014
79histone H2A monoubiquitination (GO:0035518)2.52586872
80translesion synthesis (GO:0019985)2.52517500
81meiotic chromosome segregation (GO:0045132)2.48141321
82regulation of spindle organization (GO:0090224)2.46663660
83cytoplasmic mRNA processing body assembly (GO:0033962)2.46263125
84histone H3-K4 methylation (GO:0051568)2.43395137
85chromatin assembly or disassembly (GO:0006333)2.42375607
86detection of bacterium (GO:0016045)2.42181594
87kinetochore organization (GO:0051383)2.42173886
88negative regulation of erythrocyte differentiation (GO:0045647)2.41768285
89peptidyl-threonine phosphorylation (GO:0018107)2.41448115
90glucocorticoid receptor signaling pathway (GO:0042921)2.41315675
91nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.40919765
92positive T cell selection (GO:0043368)2.40363400
93peptidyl-threonine modification (GO:0018210)2.40260333
94regulation of mitotic spindle organization (GO:0060236)2.38163896
95protein dealkylation (GO:0008214)2.37433832
96protein demethylation (GO:0006482)2.37433832
97negative regulation of phagocytosis (GO:0050765)2.36664531
98response to host (GO:0075136)2.36252916
99response to host defenses (GO:0052200)2.36252916
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36252916
101DNA conformation change (GO:0071103)2.35826583
102positive regulation of insulin receptor signaling pathway (GO:0046628)2.35038365
103germinal center formation (GO:0002467)2.35014829
104thymic T cell selection (GO:0045061)2.34765193
105regulation of necroptotic process (GO:0060544)2.33062206
106mitotic recombination (GO:0006312)2.32868810
107regulation of helicase activity (GO:0051095)2.32487598
108negative regulation of RNA splicing (GO:0033119)2.32155663
109regulation of NFAT protein import into nucleus (GO:0051532)2.32119565
110positive regulation of B cell differentiation (GO:0045579)2.32037961
111response to host immune response (GO:0052572)2.31495084
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.31495084
113histone H3-K9 modification (GO:0061647)2.31312820
1143-UTR-mediated mRNA stabilization (GO:0070935)2.30970731
115positive regulation of chromosome segregation (GO:0051984)2.30096545
116T cell selection (GO:0045058)2.30015131
117iron ion import (GO:0097286)2.28835553
118myeloid leukocyte mediated immunity (GO:0002444)2.28802439
119response to interleukin-15 (GO:0070672)2.28168643
120histone lysine demethylation (GO:0070076)2.27258825
121histone-serine phosphorylation (GO:0035404)2.26971581
122hypotonic response (GO:0006971)2.24946599
123cellular response to zinc ion (GO:0071294)2.24359820
124regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.24094857
125regulation of DNA damage checkpoint (GO:2000001)2.23608903
126megakaryocyte development (GO:0035855)2.23580871
127regulation of B cell receptor signaling pathway (GO:0050855)2.23526848
128* embryonic process involved in female pregnancy (GO:0060136)2.23238865
129positive regulation of protein import into nucleus, translocation (GO:0033160)2.22562424
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.21150399
131regulation of mRNA stability (GO:0043488)2.20758219
132positive regulation of protein deacetylation (GO:0090312)2.20674444
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.20612618
134nucleus organization (GO:0006997)2.20444170
135sister chromatid cohesion (GO:0007062)2.19791734
136N-terminal protein amino acid acetylation (GO:0006474)2.18800001
137negative regulation of B cell proliferation (GO:0030889)2.18707883
138neural tube formation (GO:0001841)2.18366871
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.18013335
140interkinetic nuclear migration (GO:0022027)2.17930145
141morphogenesis of an endothelium (GO:0003159)2.17488080
142endothelial tube morphogenesis (GO:0061154)2.17488080
143protein localization to chromosome (GO:0034502)2.16021330
144chromosome condensation (GO:0030261)2.15603111
145histone H3-K36 demethylation (GO:0070544)2.15426078
146histone demethylation (GO:0016577)2.15193108
147regulation of B cell differentiation (GO:0045577)2.15119234
148microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.14459316
149corticosteroid receptor signaling pathway (GO:0031958)2.14372664
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.14348568
151nuclear envelope organization (GO:0006998)2.13989703
152negative regulation of histone modification (GO:0031057)2.13461986
153interferon-gamma production (GO:0032609)2.13221096
154B cell receptor signaling pathway (GO:0050853)2.13201451
155negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.12453827
156pre-miRNA processing (GO:0031054)2.12421161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78011176
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.63361679
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.49788125
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.26854370
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88271319
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29508010
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21141432
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94568291
9MYC_22102868_ChIP-Seq_BL_Human2.77576805
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.66650778
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.57006489
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39885102
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.32765270
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16742748
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07447290
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01995821
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01746408
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00991999
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99930458
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96016356
21* MYB_26560356_Chip-Seq_TH2_Human1.92533020
22* E2F1_21310950_ChIP-Seq_MCF-7_Human1.92087293
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89296637
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87168487
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76612221
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75437261
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74160444
28* MYB_26560356_Chip-Seq_TH1_Human1.72587993
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70757095
30* MAF_26560356_Chip-Seq_TH1_Human1.66843740
31VDR_21846776_ChIP-Seq_THP-1_Human1.66797449
32RUNX_20019798_ChIP-Seq_JUKART_Human1.65196313
33AR_21909140_ChIP-Seq_LNCAP_Human1.62913769
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61699548
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.60635447
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60187445
37SCL_19346495_ChIP-Seq_HPC-7_Human1.57471222
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57334394
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56118310
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.55049774
41* UTX_26944678_Chip-Seq_JUKART_Human1.54523129
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51285608
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51063793
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49880975
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.47848715
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.45204828
47GATA1_22025678_ChIP-Seq_K562_Human1.44470444
48ELK1_19687146_ChIP-ChIP_HELA_Human1.42180508
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41313173
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39088818
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38343930
52* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37907152
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.37112652
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35915479
55* CLOCK_20551151_ChIP-Seq_293T_Human1.34671575
56* IRF8_27001747_Chip-Seq_BMDM_Mouse1.34592084
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32702708
58* SPI1_23547873_ChIP-Seq_NB4_Human1.32215674
59CIITA_25753668_ChIP-Seq_RAJI_Human1.31030851
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29438628
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29438628
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29438628
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29322467
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28764627
65VDR_24787735_ChIP-Seq_THP-1_Human1.28760211
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.26812757
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26707354
68* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26373690
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22601643
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22245675
71* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20478968
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18214230
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17799481
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17788446
75VDR_24763502_ChIP-Seq_THP-1_Human1.15598499
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15183147
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13111015
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12387689
79GATA3_27048872_Chip-Seq_THYMUS_Human1.09338328
80* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08595158
81TFEB_21752829_ChIP-Seq_HELA_Human1.08504384
82* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08183035
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07636425
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07487881
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07208080
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07168923
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05167984
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04945939
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04553481
90* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04320266
91* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04111611
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02934600
93PU_27001747_Chip-Seq_BMDM_Mouse1.02266040
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02086417
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.01784758
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01014562
97VDR_23849224_ChIP-Seq_CD4+_Human1.00727614
98BRD4_25478319_ChIP-Seq_HGPS_Human1.00294137
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.97263918
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97095279
101KDM2B_26808549_Chip-Seq_DND41_Human0.96564074
102ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96256998
103FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94959906
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.94675833
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94332173
106SPI1_23127762_ChIP-Seq_K562_Human0.94050470
107NCOR1_26117541_ChIP-Seq_K562_Human0.93755404
108KDM5A_27292631_Chip-Seq_BREAST_Human0.93068703
109* CHD1_26751641_Chip-Seq_LNCaP_Human0.92446416
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92015878
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91751466
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90907463
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90171367
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90171367
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88293980
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88123190
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87785598
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86222335
119FOXP3_21729870_ChIP-Seq_TREG_Human0.85955871
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85868258
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85779286
122* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85343140
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85275781
124* FOXO3_23340844_ChIP-Seq_DLD1_Human0.85054882
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85029627
126* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84940655
127* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84657243
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82344111
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81784756
130* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81201153
131* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80959494
132* ELK3_25401928_ChIP-Seq_HUVEC_Human0.79907076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002166_altered_tumor_susceptibility2.71314373
2MP0010352_gastrointestinal_tract_polyps2.68610675
3MP0002009_preneoplasia2.50098053
4MP0003300_gastrointestinal_ulcer2.44894306
5MP0006054_spinal_hemorrhage2.40785253
6MP0002396_abnormal_hematopoietic_system2.27648449
7MP0003763_abnormal_thymus_physiology2.24355074
8MP0003724_increased_susceptibility_to2.18835973
9MP0003705_abnormal_hypodermis_morpholog2.14698646
10MP0010094_abnormal_chromosome_stability2.13672041
11MP0002877_abnormal_melanocyte_morpholog2.12242454
12MP0005076_abnormal_cell_differentiation2.10819323
13MP0003221_abnormal_cardiomyocyte_apopto2.06496516
14MP0002006_tumorigenesis2.04967666
15MP0008260_abnormal_autophagy2.03077182
16MP0004808_abnormal_hematopoietic_stem1.96942227
17MP0010307_abnormal_tumor_latency1.93321719
18MP0010234_abnormal_vibrissa_follicle1.90788361
19MP0000685_abnormal_immune_system1.85781503
20MP0001835_abnormal_antigen_presentation1.85051760
21MP0003077_abnormal_cell_cycle1.81100728
22MP0008057_abnormal_DNA_replication1.80928537
23MP0003111_abnormal_nucleus_morphology1.80385521
24MP0003656_abnormal_erythrocyte_physiolo1.77545866
25MP0009278_abnormal_bone_marrow1.76890005
26MP0001800_abnormal_humoral_immune1.64476023
27* MP0002398_abnormal_bone_marrow1.63032430
28MP0008007_abnormal_cellular_replicative1.58585676
29MP0008438_abnormal_cutaneous_collagen1.56848393
30MP0005671_abnormal_response_to1.54411278
31MP0001873_stomach_inflammation1.53573022
32MP0005397_hematopoietic_system_phenotyp1.53318176
33MP0001545_abnormal_hematopoietic_system1.53318176
34MP0004957_abnormal_blastocyst_morpholog1.53111349
35MP0003566_abnormal_cell_adhesion1.49987026
36MP0003693_abnormal_embryo_hatching1.47940884
37MP0000490_abnormal_crypts_of1.45895491
38MP0000703_abnormal_thymus_morphology1.45313062
39MP0002452_abnormal_antigen_presenting1.42549944
40MP0010155_abnormal_intestine_physiology1.38833757
41MP0002420_abnormal_adaptive_immunity1.37507399
42MP0001819_abnormal_immune_cell1.35621954
43MP0005387_immune_system_phenotype1.35559698
44MP0001790_abnormal_immune_system1.35559698
45MP0003890_abnormal_embryonic-extraembry1.34409957
46* MP0002722_abnormal_immune_system1.34230240
47MP0005451_abnormal_body_composition1.33909486
48MP0010678_abnormal_skin_adnexa1.32918918
49MP0003567_abnormal_fetal_cardiomyocyte1.31529962
50MP0000350_abnormal_cell_proliferation1.31213026
51MP0000689_abnormal_spleen_morphology1.31096692
52MP0000569_abnormal_digit_pigmentation1.28756899
53MP0001851_eye_inflammation1.27958636
54* MP0000716_abnormal_immune_system1.27428588
55MP0004947_skin_inflammation1.24142817
56MP0002723_abnormal_immune_serum1.22360377
57* MP0002086_abnormal_extraembryonic_tissu1.20623895
58MP0002405_respiratory_system_inflammati1.19182508
59MP0005023_abnormal_wound_healing1.17551228
60MP0003436_decreased_susceptibility_to1.17533213
61MP0004197_abnormal_fetal_growth/weight/1.16405751
62MP0005000_abnormal_immune_tolerance1.15194932
63* MP0002429_abnormal_blood_cell1.15066878
64MP0000858_altered_metastatic_potential1.14089214
65MP0002019_abnormal_tumor_incidence1.09076186
66MP0000537_abnormal_urethra_morphology1.09069487
67MP0003191_abnormal_cellular_cholesterol1.08984204
68MP0005621_abnormal_cell_physiology1.08673192
69MP0003303_peritoneal_inflammation1.07959203
70MP0008058_abnormal_DNA_repair1.07268172
71MP0003091_abnormal_cell_migration1.07077554
72MP0003448_altered_tumor_morphology1.05191826
73MP0002088_abnormal_embryonic_growth/wei1.03776805
74MP0001730_embryonic_growth_arrest1.03509144
75MP0005025_abnormal_response_to1.02560323
76MP0003984_embryonic_growth_retardation1.02489046
77MP0005275_abnormal_skin_tensile1.02201993
78MP0004883_abnormal_blood_vessel1.01788300
79MP0004264_abnormal_extraembryonic_tissu1.01674375
80MP0001672_abnormal_embryogenesis/_devel1.01089646
81MP0005380_embryogenesis_phenotype1.01089646
82MP0004381_abnormal_hair_follicle0.99994668
83MP0000465_gastrointestinal_hemorrhage0.99928732
84MP0005310_abnormal_salivary_gland0.99415174
85MP0001915_intracranial_hemorrhage0.99223952
86MP0003453_abnormal_keratinocyte_physiol0.97621566
87MP0005409_darkened_coat_color0.97420618
88MP0009785_altered_susceptibility_to0.97232264
89MP0009333_abnormal_splenocyte_physiolog0.96263681
90MP0002060_abnormal_skin_morphology0.95564590
91MP0001697_abnormal_embryo_size0.95070585
92MP0002419_abnormal_innate_immunity0.95058829
93MP0001879_abnormal_lymphatic_vessel0.93795827
94MP0000383_abnormal_hair_follicle0.93742887
95MP0000733_abnormal_muscle_development0.92674309
96MP0005464_abnormal_platelet_physiology0.92498027
97MP0000428_abnormal_craniofacial_morphol0.91467462
98MP0003115_abnormal_respiratory_system0.90255012
99MP0003121_genomic_imprinting0.89665875
100MP0001845_abnormal_inflammatory_respons0.88083365
101MP0002084_abnormal_developmental_patter0.88064666
102MP0001853_heart_inflammation0.84633282
103MP0003943_abnormal_hepatobiliary_system0.83576860
104MP0002092_abnormal_eye_morphology0.82684988
105MP0009053_abnormal_anal_canal0.82504567
106MP0002928_abnormal_bile_duct0.82158758
107MP0002925_abnormal_cardiovascular_devel0.81811439
108MP0002080_prenatal_lethality0.80906552
109MP0002998_abnormal_bone_remodeling0.80304294
110MP0009672_abnormal_birth_weight0.79349545
111MP0005248_abnormal_Harderian_gland0.79294088
112MP0004185_abnormal_adipocyte_glucose0.78585964
113MP0000377_abnormal_hair_follicle0.77867568
114MP0005164_abnormal_response_to0.76254392
115MP0002085_abnormal_embryonic_tissue0.76009444
116MP0003828_pulmonary_edema0.75697944
117MP0003123_paternal_imprinting0.74986837
118MP0001216_abnormal_epidermal_layer0.74030088
119MP0002133_abnormal_respiratory_system0.73868056
120MP0005388_respiratory_system_phenotype0.73868056
121MP0000477_abnormal_intestine_morphology0.73854110
122MP0000371_diluted_coat_color0.73334964
123MP0001243_abnormal_dermal_layer0.73179984
124MP0000313_abnormal_cell_death0.72978386
125* MP0009703_decreased_birth_body0.72514150
126MP0002933_joint_inflammation0.71318558
127MP0005503_abnormal_tendon_morphology0.70849935

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.85928376
2Volvulus (HP:0002580)3.36165133
3Abnormality of the fingertips (HP:0001211)2.98636869
4Hematochezia (HP:0002573)2.97274906
5Curly hair (HP:0002212)2.97085458
6Asymmetry of the thorax (HP:0001555)2.87873230
7T lymphocytopenia (HP:0005403)2.82267470
8Abnormality of T cell number (HP:0011839)2.76291264
9Subacute progressive viral hepatitis (HP:0006572)2.69806307
10Thyroid carcinoma (HP:0002890)2.68536581
11Recurrent viral infections (HP:0004429)2.68289967
12Transitional cell carcinoma of the bladder (HP:0006740)2.67575312
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66158151
14Short 4th metacarpal (HP:0010044)2.66158151
15IgM deficiency (HP:0002850)2.60590668
16Colon cancer (HP:0003003)2.51792354
17Bladder neoplasm (HP:0009725)2.51493397
18Bladder carcinoma (HP:0002862)2.51493397
19Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.49549521
20Nephroblastoma (Wilms tumor) (HP:0002667)2.41443552
21Syringomyelia (HP:0003396)2.39773573
22Spinal cord lesions (HP:0100561)2.39773573
23Embryonal renal neoplasm (HP:0011794)2.33553013
24Leiomyosarcoma (HP:0100243)2.32961779
25Uterine leiomyosarcoma (HP:0002891)2.32961779
26Abnormality of B cell number (HP:0010975)2.29389192
27B lymphocytopenia (HP:0010976)2.29389192
28Cystic hygroma (HP:0000476)2.28149739
29Absent frontal sinuses (HP:0002688)2.25653115
30Cellulitis (HP:0100658)2.25593094
31Abnormal foot bone ossification (HP:0010675)2.25313312
32Spontaneous hematomas (HP:0007420)2.24220212
33Abnormality of T cells (HP:0002843)2.24209237
34Recurrent bronchitis (HP:0002837)2.21918313
35Heterotopia (HP:0002282)2.20372361
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19640306
37Vertebral arch anomaly (HP:0008438)2.19272937
38IgA deficiency (HP:0002720)2.17769180
39Thrombocytosis (HP:0001894)2.17520276
40Recurrent fungal infections (HP:0002841)2.17155686
41Ankyloglossia (HP:0010296)2.16724338
42Osteolytic defects of the hand bones (HP:0009699)2.16050287
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.16050287
44Deviation of the thumb (HP:0009603)2.15729838
45Gingivitis (HP:0000230)2.15667647
46Prominent nose (HP:0000448)2.14822469
47Basal cell carcinoma (HP:0002671)2.12388310
48Termporal pattern (HP:0011008)2.11698092
49Insidious onset (HP:0003587)2.11698092
50Thickened calvaria (HP:0002684)2.10270466
51Thyroiditis (HP:0100646)2.09625473
52Gastrointestinal infarctions (HP:0005244)2.08138490
53Micronodular cirrhosis (HP:0001413)2.07878272
54Viral hepatitis (HP:0006562)2.07024703
55Long eyelashes (HP:0000527)2.06285385
56Acute myeloid leukemia (HP:0004808)2.05264591
57Ankle contracture (HP:0006466)2.05187222
58Biliary tract neoplasm (HP:0100574)2.04700815
59Cerebral aneurysm (HP:0004944)2.04446272
60Proximal placement of thumb (HP:0009623)2.03229043
61Large earlobe (HP:0009748)2.02892135
62Myositis (HP:0100614)2.02482266
63Aortic aneurysm (HP:0004942)2.02251522
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.01802946
65High pitched voice (HP:0001620)2.01239269
66Rectal prolapse (HP:0002035)2.00976494
67Cutis marmorata (HP:0000965)2.00459329
68Menstrual irregularities (HP:0000858)1.98845199
69Abnormal platelet volume (HP:0011876)1.98252753
70Flat acetabular roof (HP:0003180)1.98027753
71Mitral valve prolapse (HP:0001634)1.97982088
72Increased nuchal translucency (HP:0010880)1.97417202
73Eczematoid dermatitis (HP:0000976)1.97150931
74Selective tooth agenesis (HP:0001592)1.96277757
75Germ cell neoplasia (HP:0100728)1.96244745
76Cutaneous melanoma (HP:0012056)1.94451432
77Optic neuritis (HP:0100653)1.92463083
78Retrobulbar optic neuritis (HP:0100654)1.92463083
79Recurrent abscess formation (HP:0002722)1.91773678
80Panhypogammaglobulinemia (HP:0003139)1.91718886
81Keratoconjunctivitis sicca (HP:0001097)1.89917019
82Abnormality of the 4th metacarpal (HP:0010012)1.89681508
83Eosinophilia (HP:0001880)1.88495178
84Recurrent gram-negative bacterial infections (HP:0005420)1.88028688
85Persistence of primary teeth (HP:0006335)1.88016699
86Gastrointestinal carcinoma (HP:0002672)1.87933629
87Malignant gastrointestinal tract tumors (HP:0006749)1.87933629
88Colitis (HP:0002583)1.87353092
89Sandal gap (HP:0001852)1.87335005
90Abnormality of oral frenula (HP:0000190)1.87017464
91Abnormality of chromosome stability (HP:0003220)1.86933258
92Entropion (HP:0000621)1.86813091
93Dislocated radial head (HP:0003083)1.86761294
94Broad palm (HP:0001169)1.86719096
95Coarse hair (HP:0002208)1.86063905
96IgG deficiency (HP:0004315)1.84786800
97Orchitis (HP:0100796)1.84285445
98Mediastinal lymphadenopathy (HP:0100721)1.84228614
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83445427
100Lymphoma (HP:0002665)1.81491810
101Elevated erythrocyte sedimentation rate (HP:0003565)1.81429145
102Increased density of long bones (HP:0006392)1.81312763
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.81061084
104Recurrent skin infections (HP:0001581)1.78780594
105Increased mean platelet volume (HP:0011877)1.78660219
106Abnormality of cells of the lymphoid lineage (HP:0012140)1.78544324
107Truncal obesity (HP:0001956)1.78542678
108Chromsome breakage (HP:0040012)1.78511152
109Somatic mutation (HP:0001428)1.78164271
110Subaortic stenosis (HP:0001682)1.78058346
111Abnormality of the left ventricular outflow tract (HP:0011103)1.78058346
112Recurrent cutaneous fungal infections (HP:0011370)1.76602855
113Chronic mucocutaneous candidiasis (HP:0002728)1.76602855
114Medulloblastoma (HP:0002885)1.76178422
115Bicuspid aortic valve (HP:0001647)1.75894067
116Blepharitis (HP:0000498)1.75493860
117Relative macrocephaly (HP:0004482)1.75317403
118Aortic dissection (HP:0002647)1.74544628
119Abnormality of T cell physiology (HP:0011840)1.74421295
120Deep philtrum (HP:0002002)1.74037315
121Periodontitis (HP:0000704)1.73398990
122Myelodysplasia (HP:0002863)1.73122773
123Lymphopenia (HP:0001888)1.73016292
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72330209
125Abnormality of the lumbar spine (HP:0100712)1.72225258
126Gingival bleeding (HP:0000225)1.72145103
127Hypoplasia of the thymus (HP:0000778)1.69557553
128Agammaglobulinemia (HP:0004432)1.69541699
129Inflammation of the large intestine (HP:0002037)1.68308037
130Renal cell carcinoma (HP:0005584)1.68264528
131Dilatation of the ascending aorta (HP:0005111)1.68247456
132Hyperacusis (HP:0010780)1.67965333
133Metaphyseal cupping (HP:0003021)1.67524655
134Mesomelia (HP:0003027)1.66647095
135Thoracolumbar scoliosis (HP:0002944)1.66324972
136Low anterior hairline (HP:0000294)1.66110891
137Autoimmune thrombocytopenia (HP:0001973)1.65545389
138Abnormality of the columella (HP:0009929)1.64479025
139Spondylolisthesis (HP:0003302)1.64054044
140Abnormality of the radial head (HP:0003995)1.63682125
141Chest pain (HP:0100749)1.63599085
142Keratoconjunctivitis (HP:0001096)1.63163363
143Combined immunodeficiency (HP:0005387)1.63067729
144Osteomyelitis (HP:0002754)1.63029039
145Anal stenosis (HP:0002025)1.62707309
146Poikiloderma (HP:0001029)1.62445056
147Gastrointestinal inflammation (HP:0004386)1.62279131
148Pustule (HP:0200039)1.62114655
149Arterial thrombosis (HP:0004420)1.62100114
150Meningitis (HP:0001287)1.61669012
151Rhabdomyosarcoma (HP:0002859)1.60798578
152Recurrent bacterial skin infections (HP:0005406)1.60606500
153Protrusio acetabuli (HP:0003179)1.60027649
154Fatigue (HP:0012378)1.59151090
155Papilloma (HP:0012740)1.58566139
156Verrucae (HP:0200043)1.58566139
157Autoimmune hemolytic anemia (HP:0001890)1.57859907
158Abnormality of the peritoneum (HP:0002585)1.56557104
159Severe combined immunodeficiency (HP:0004430)1.56498826
160Narrow palate (HP:0000189)1.56375957
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56035848
162Amaurosis fugax (HP:0100576)1.55834633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B2.61949269
2CDC72.26965538
3MAP3K102.25078629
4STK102.23733008
5MAP4K12.22339006
6PKN22.21999602
7CDK122.20465360
8EEF2K2.16704047
9FGFR32.03600228
10CDK61.97966994
11JAK31.97479776
12AKT31.87639385
13FLT31.84501247
14SCYL21.83818812
15MAP3K21.80450949
16NEK21.77219260
17TYK21.76170087
18MAP3K61.71528299
19TRIB31.70595825
20RIPK41.57741014
21PTK61.57412838
22LRRK21.54844405
23NLK1.53770007
24FGFR41.52015752
25TGFBR21.47895683
26RPS6KB21.47519766
27IRAK11.46990300
28PASK1.45911510
29ITK1.45724888
30PIM11.45690708
31CDK41.41309021
32TXK1.41041547
33STK41.40432413
34TGFBR11.39669798
35IRAK21.38806008
36MAP3K141.38428243
37STK31.32815649
38NEK91.32655427
39CDK91.32496061
40FRK1.32203596
41KSR21.30558359
42JAK11.30341363
43RPS6KA41.27411279
44BLK1.26300944
45TEC1.25858390
46MELK1.25292392
47STK38L1.24810153
48RIPK11.24457840
49GRK61.24184457
50EPHA31.23757029
51SGK21.23234963
52SIK31.23048707
53BRD41.22385131
54EIF2AK31.20634435
55LATS11.20508771
56STK241.20379968
57BTK1.19837763
58SRPK11.19024126
59DYRK31.18454397
60TTN1.16461140
61BMPR21.16327738
62CAMKK21.11636008
63PDGFRA1.10771402
64ATR1.09367796
65RET1.08958829
66KSR11.07922989
67CSK1.05920262
68FGR1.05140131
69ZAP701.03647006
70AURKB1.02753494
71DYRK1B1.02341450
72TRPM71.01152359
73WEE10.99954779
74MKNK20.98637872
75MKNK10.98150961
76CAMK1D0.98043801
77PIK3CG0.96531240
78CSF1R0.94719764
79ZAK0.94408140
80BCR0.92357604
81KIT0.92338059
82ACVR1B0.91168303
83NUAK10.88282507
84CLK10.87336940
85IKBKE0.85909471
86TLK10.85825614
87CHUK0.85052987
88BRSK20.84716252
89RAF10.81935779
90TAF10.81464389
91WNK10.81290863
92MAP3K80.80578267
93PAK40.80428889
94MAP2K30.80108907
95LCK0.79455973
96MARK30.76888842
97PDGFRB0.75912433
98FES0.75314831
99ATM0.74909965
100SMG10.73324309
101TBK10.73056996
102JAK20.72541409
103MAP3K40.71764520
104HIPK20.71550842
105NEK60.71332852
106CHEK10.69767553
107HCK0.68753991
108ERBB30.66576782
109FGFR10.66214782
110CHEK20.65891155
111TTK0.64994514
112IKBKB0.64928677
113MARK20.64478142
114CDK70.63002904
115FGFR20.62905061
116SIK10.60174661
117IRAK40.59425650
118YES10.57505938
119MAP3K70.57439859
120ALK0.56999131
121PLK10.56718836
122MTOR0.56385318
123MAP3K130.54407655
124MAP2K40.54016486
125EPHB10.53800973
126LATS20.53303637
127DMPK0.52905258
128SGK30.52643186
129MAP3K10.51925188
130SGK4940.50359391
131SGK2230.50359391
132SYK0.50348207
133ERN10.49371477
134CDK20.48919160
135RPS6KB10.47913574
136LYN0.45372698
137MATK0.44261001
138MAPK110.44099646
139PLK30.41497741
140VRK10.39592610

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.35268796
2DNA replication_Homo sapiens_hsa030302.18567393
3Systemic lupus erythematosus_Homo sapiens_hsa053222.06175336
4Mismatch repair_Homo sapiens_hsa034301.94455059
5Cell cycle_Homo sapiens_hsa041101.88016368
6Antigen processing and presentation_Homo sapiens_hsa046121.87829015
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.74003066
8Small cell lung cancer_Homo sapiens_hsa052221.68032186
9Measles_Homo sapiens_hsa051621.67838961
10Renal cell carcinoma_Homo sapiens_hsa052111.66177136
11Chronic myeloid leukemia_Homo sapiens_hsa052201.65518016
12Viral carcinogenesis_Homo sapiens_hsa052031.62539688
13B cell receptor signaling pathway_Homo sapiens_hsa046621.59143034
14Base excision repair_Homo sapiens_hsa034101.54634958
15Herpes simplex infection_Homo sapiens_hsa051681.54573866
16Non-homologous end-joining_Homo sapiens_hsa034501.52683219
17p53 signaling pathway_Homo sapiens_hsa041151.52382523
18One carbon pool by folate_Homo sapiens_hsa006701.49995978
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49141922
20T cell receptor signaling pathway_Homo sapiens_hsa046601.45989967
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.43972919
22Leishmaniasis_Homo sapiens_hsa051401.43191947
23MicroRNAs in cancer_Homo sapiens_hsa052061.42097652
24Spliceosome_Homo sapiens_hsa030401.40746240
25Osteoclast differentiation_Homo sapiens_hsa043801.40549564
26Pancreatic cancer_Homo sapiens_hsa052121.38810650
27Hepatitis B_Homo sapiens_hsa051611.37809504
28Adherens junction_Homo sapiens_hsa045201.34302672
29Colorectal cancer_Homo sapiens_hsa052101.33043601
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31898734
31Toxoplasmosis_Homo sapiens_hsa051451.29209070
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.27440968
33RNA transport_Homo sapiens_hsa030131.25861284
34HTLV-I infection_Homo sapiens_hsa051661.24148903
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23897559
36Inositol phosphate metabolism_Homo sapiens_hsa005621.21956828
37ErbB signaling pathway_Homo sapiens_hsa040121.19528668
38Fanconi anemia pathway_Homo sapiens_hsa034601.19475039
39Glioma_Homo sapiens_hsa052141.18339932
40Hematopoietic cell lineage_Homo sapiens_hsa046401.18160143
41Acute myeloid leukemia_Homo sapiens_hsa052211.17990909
42Viral myocarditis_Homo sapiens_hsa054161.17446296
43Thyroid cancer_Homo sapiens_hsa052161.17067850
44Nucleotide excision repair_Homo sapiens_hsa034201.16580514
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16347933
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16004744
47Apoptosis_Homo sapiens_hsa042101.13922608
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13315983
49Prostate cancer_Homo sapiens_hsa052151.11946053
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11793721
51mRNA surveillance pathway_Homo sapiens_hsa030151.10673678
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.10322667
53Choline metabolism in cancer_Homo sapiens_hsa052311.08825200
54Dorso-ventral axis formation_Homo sapiens_hsa043201.08569564
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06272450
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06176637
57Lysine degradation_Homo sapiens_hsa003101.06022255
58Non-small cell lung cancer_Homo sapiens_hsa052231.05308515
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02984496
60TNF signaling pathway_Homo sapiens_hsa046681.01941722
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01589542
62Homologous recombination_Homo sapiens_hsa034401.01051855
63Influenza A_Homo sapiens_hsa051640.99714926
64Proteoglycans in cancer_Homo sapiens_hsa052050.99412948
65mTOR signaling pathway_Homo sapiens_hsa041500.97199542
66Endometrial cancer_Homo sapiens_hsa052130.97156274
67Legionellosis_Homo sapiens_hsa051340.97151825
68Platelet activation_Homo sapiens_hsa046110.96683226
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96087624
70RNA degradation_Homo sapiens_hsa030180.95251491
71Shigellosis_Homo sapiens_hsa051310.95079345
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94410778
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94233110
74Focal adhesion_Homo sapiens_hsa045100.92657492
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92348481
76Epstein-Barr virus infection_Homo sapiens_hsa051690.89198288
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88093203
78FoxO signaling pathway_Homo sapiens_hsa040680.86566214
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85512521
80TGF-beta signaling pathway_Homo sapiens_hsa043500.85313240
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.84138727
82Notch signaling pathway_Homo sapiens_hsa043300.80928486
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80463176
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76947097
85Chemokine signaling pathway_Homo sapiens_hsa040620.75183725
86Insulin signaling pathway_Homo sapiens_hsa049100.74723750
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74259755
88Amoebiasis_Homo sapiens_hsa051460.74087478
89Pathways in cancer_Homo sapiens_hsa052000.73696655
90Insulin resistance_Homo sapiens_hsa049310.72288940
91Alcoholism_Homo sapiens_hsa050340.70477748
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68739450
93Prolactin signaling pathway_Homo sapiens_hsa049170.68639485
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.68403851
95Hepatitis C_Homo sapiens_hsa051600.67952085
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67279833
97Melanoma_Homo sapiens_hsa052180.66765365
98ECM-receptor interaction_Homo sapiens_hsa045120.66649826
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.65474198
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63807969
101Tuberculosis_Homo sapiens_hsa051520.63615113
102Type II diabetes mellitus_Homo sapiens_hsa049300.61566736
103Bladder cancer_Homo sapiens_hsa052190.60789917
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59641530
105Estrogen signaling pathway_Homo sapiens_hsa049150.59286324
106Staphylococcus aureus infection_Homo sapiens_hsa051500.58852552
107GnRH signaling pathway_Homo sapiens_hsa049120.58182745
108Circadian rhythm_Homo sapiens_hsa047100.55651772
109Hippo signaling pathway_Homo sapiens_hsa043900.55550676
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.54996419
111Malaria_Homo sapiens_hsa051440.54958609
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54775117
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54681736
114Salmonella infection_Homo sapiens_hsa051320.54675035
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53159326
116Graft-versus-host disease_Homo sapiens_hsa053320.52936787
117Pertussis_Homo sapiens_hsa051330.51910962
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51378337
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.51243978
120VEGF signaling pathway_Homo sapiens_hsa043700.50853084
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50573399
122Selenocompound metabolism_Homo sapiens_hsa004500.49953438
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49861996

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