SP3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to chromosome, centromeric region (GO:0071459)7.53647836
2positive regulation of mitotic sister chromatid separation (GO:1901970)7.01087908
3positive regulation of mitotic metaphase/anaphase transition (GO:0045842)7.01087908
4positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)7.01087908
5protein localization to kinetochore (GO:0034501)6.63448210
6positive regulation of chromosome segregation (GO:0051984)6.35329423
7mitotic metaphase plate congression (GO:0007080)6.07082384
8regulation of spindle organization (GO:0090224)5.66186349
9mitotic chromosome condensation (GO:0007076)5.46175720
10viral transcription (GO:0019083)5.39850657
11regulation of mitotic spindle organization (GO:0060236)5.35266035
12translational termination (GO:0006415)5.20022376
13attachment of spindle microtubules to kinetochore (GO:0008608)5.16206860
14metaphase plate congression (GO:0051310)5.11911226
15mitotic sister chromatid segregation (GO:0000070)4.96357426
16protein localization to chromosome (GO:0034502)4.91211517
17ribosomal small subunit biogenesis (GO:0042274)4.69554075
18establishment of chromosome localization (GO:0051303)4.55327159
19ribosomal small subunit assembly (GO:0000028)4.54154398
20translational elongation (GO:0006414)4.50267723
21sister chromatid segregation (GO:0000819)4.45889299
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.31747548
23regulation of sister chromatid cohesion (GO:0007063)4.30652315
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.29868435
25cotranslational protein targeting to membrane (GO:0006613)4.27333222
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26517075
27protein targeting to ER (GO:0045047)4.22408781
28maturation of SSU-rRNA (GO:0030490)4.21465945
29cellular protein complex disassembly (GO:0043624)4.21450825
30regulation of chromosome segregation (GO:0051983)4.20706950
31DNA strand elongation involved in DNA replication (GO:0006271)4.15843277
32kinetochore organization (GO:0051383)4.11416547
33translational initiation (GO:0006413)4.09051348
34ribosomal large subunit biogenesis (GO:0042273)4.08464317
35meiotic cell cycle (GO:0051321)4.07719123
36establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06234771
37regulation of mitotic sister chromatid separation (GO:0010965)4.06052652
38regulation of mitotic sister chromatid segregation (GO:0033047)4.06052652
39regulation of sister chromatid segregation (GO:0033045)4.06052652
40regulation of mitotic metaphase/anaphase transition (GO:0030071)4.03859918
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.03859918
42DNA strand elongation (GO:0022616)3.99734433
43protein K6-linked ubiquitination (GO:0085020)3.96765357
44viral life cycle (GO:0019058)3.94829815
45protein localization to endoplasmic reticulum (GO:0070972)3.94144380
46CENP-A containing nucleosome assembly (GO:0034080)3.91925218
47telomere maintenance via semi-conservative replication (GO:0032201)3.90090742
48negative regulation of chromosome segregation (GO:0051985)3.80890739
49spindle checkpoint (GO:0031577)3.79562952
50microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.74046349
51protein complex disassembly (GO:0043241)3.72509830
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.68890294
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68890294
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.68890294
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.68890294
56negative regulation of sister chromatid segregation (GO:0033046)3.68890294
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66327662
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65568538
59chromatin remodeling at centromere (GO:0031055)3.58941847
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57068383
61mitotic spindle checkpoint (GO:0071174)3.55694808
62DNA damage response, detection of DNA damage (GO:0042769)3.55086031
63DNA topological change (GO:0006265)3.54250308
64DNA ligation (GO:0006266)3.53204009
65macromolecular complex disassembly (GO:0032984)3.52327096
66ribonucleoprotein complex biogenesis (GO:0022613)3.51320394
67mitotic spindle assembly checkpoint (GO:0007094)3.51091531
68purine nucleobase biosynthetic process (GO:0009113)3.46254505
69IMP biosynthetic process (GO:0006188)3.45327647
70kinetochore assembly (GO:0051382)3.43064471
71spindle assembly checkpoint (GO:0071173)3.41842656
72regulation of RNA export from nucleus (GO:0046831)3.39554115
73regulation of mitochondrial translation (GO:0070129)3.38700314
74histone exchange (GO:0043486)3.38574493
75DNA unwinding involved in DNA replication (GO:0006268)3.37768936
76folic acid-containing compound biosynthetic process (GO:0009396)3.34158629
77mitotic nuclear envelope disassembly (GO:0007077)3.31916815
78telomere maintenance via recombination (GO:0000722)3.31272543
79mitochondrial fusion (GO:0008053)3.29290636
80chromosome condensation (GO:0030261)3.25318946
81establishment of integrated proviral latency (GO:0075713)3.25295362
82nuclear-transcribed mRNA catabolic process (GO:0000956)3.17889482
83spliceosomal snRNP assembly (GO:0000387)3.15355765
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14695739
85IMP metabolic process (GO:0046040)3.12240282
86DNA replication-independent nucleosome organization (GO:0034724)3.09909785
87DNA replication-independent nucleosome assembly (GO:0006336)3.09909785
88mRNA catabolic process (GO:0006402)3.08487635
89inner mitochondrial membrane organization (GO:0007007)3.06180351
90ATP synthesis coupled proton transport (GO:0015986)3.03046892
91energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03046892
92regulation of histone H3-K9 methylation (GO:0051570)3.02856997
93mitotic recombination (GO:0006312)3.02308180
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01349324
95chromosome segregation (GO:0007059)3.00580431
96negative regulation of histone methylation (GO:0031061)2.99111038
97nuclear envelope disassembly (GO:0051081)2.98704920
98membrane disassembly (GO:0030397)2.98704920
99nucleobase biosynthetic process (GO:0046112)2.98340390
100RNA catabolic process (GO:0006401)2.96161836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25321889
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.02199793
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.68878900
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.41236647
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39862711
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.09051568
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55332783
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38351397
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37196005
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16301351
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.11964312
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04614488
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80016676
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75274709
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74977499
16AR_21909140_ChIP-Seq_LNCAP_Human2.72938450
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.59542062
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57635678
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.46536778
20XRN2_22483619_ChIP-Seq_HELA_Human2.46183814
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35522554
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28588676
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28142226
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27449548
25TTF2_22483619_ChIP-Seq_HELA_Human2.26729226
26MYC_22102868_ChIP-Seq_BL_Human2.09106799
27DCP1A_22483619_ChIP-Seq_HELA_Human2.06888070
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05962485
29FOXP3_21729870_ChIP-Seq_TREG_Human2.04295910
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03918645
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96351592
32VDR_23849224_ChIP-Seq_CD4+_Human1.95719053
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89828034
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.86979129
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.85643467
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83074837
37CIITA_25753668_ChIP-Seq_RAJI_Human1.79935541
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75872323
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73594165
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72167909
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.70389962
42EZH2_22144423_ChIP-Seq_EOC_Human1.68134405
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62580644
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61532955
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59297921
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58560874
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58195894
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56088504
49GABP_19822575_ChIP-Seq_HepG2_Human1.49399214
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48881219
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44051547
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43523175
53KDM5A_27292631_Chip-Seq_BREAST_Human1.42731062
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40639500
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39254717
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38445106
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38017291
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34179159
59ELK1_19687146_ChIP-ChIP_HELA_Human1.32503254
60VDR_21846776_ChIP-Seq_THP-1_Human1.30083575
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29953960
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21799472
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17681603
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16554717
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14420115
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.12781615
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10132587
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.06915883
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05809260
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05808356
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04240047
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99930749
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99795429
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89945872
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88726924
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88640025
77MYC_18940864_ChIP-ChIP_HL60_Human0.86689318
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.86459066
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85266045
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84906546
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83029671
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82642802
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81668231
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81618157
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81413946
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81338201
87EGR1_19374776_ChIP-ChIP_THP-1_Human0.78507318
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75959737
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75729564
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74820879
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73656268
92IRF1_19129219_ChIP-ChIP_H3396_Human0.73388725
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73217902
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.70264499
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69858285
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65893868
97EWS_26573619_Chip-Seq_HEK293_Human0.63158859
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62642018
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.62371298
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.61003626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18245558
2MP0003111_abnormal_nucleus_morphology4.92908656
3MP0010094_abnormal_chromosome_stability4.69655552
4MP0003077_abnormal_cell_cycle3.98877757
5MP0006292_abnormal_olfactory_placode3.81434501
6MP0004957_abnormal_blastocyst_morpholog3.81139274
7MP0003718_maternal_effect3.11941565
8MP0002138_abnormal_hepatobiliary_system3.03788711
9MP0009379_abnormal_foot_pigmentation2.88253310
10MP0008877_abnormal_DNA_methylation2.81112838
11MP0008932_abnormal_embryonic_tissue2.36701746
12MP0001346_abnormal_lacrimal_gland2.34146663
13MP0008058_abnormal_DNA_repair2.22241533
14MP0008057_abnormal_DNA_replication2.18525669
15MP0002877_abnormal_melanocyte_morpholog2.14832375
16MP0002009_preneoplasia2.13101809
17MP0001293_anophthalmia1.99992267
18MP0003890_abnormal_embryonic-extraembry1.93012255
19MP0002163_abnormal_gland_morphology1.92607960
20MP0008007_abnormal_cellular_replicative1.83552557
21MP0001730_embryonic_growth_arrest1.82231412
22MP0000350_abnormal_cell_proliferation1.81583456
23MP0010030_abnormal_orbit_morphology1.78690382
24MP0001348_abnormal_lacrimal_gland1.78316706
25MP0006072_abnormal_retinal_apoptosis1.73195620
26MP0008789_abnormal_olfactory_epithelium1.67844411
27MP0006035_abnormal_mitochondrial_morpho1.66286179
28MP0002396_abnormal_hematopoietic_system1.65312224
29MP0002277_abnormal_respiratory_mucosa1.63127705
30MP0000685_abnormal_immune_system1.62025234
31MP0000490_abnormal_crypts_of1.61099779
32MP0002139_abnormal_hepatobiliary_system1.59850376
33MP0001529_abnormal_vocalization1.59427534
34MP0003786_premature_aging1.53501732
35MP0005380_embryogenesis_phenotype1.53252135
36MP0001672_abnormal_embryogenesis/_devel1.53252135
37MP0000313_abnormal_cell_death1.27976911
38MP0008961_abnormal_basal_metabolism1.27188570
39MP0002006_tumorigenesis1.26545124
40MP0003984_embryonic_growth_retardation1.26126385
41MP0003221_abnormal_cardiomyocyte_apopto1.25479317
42MP0001929_abnormal_gametogenesis1.23867899
43MP0000427_abnormal_hair_cycle1.22508959
44MP0003567_abnormal_fetal_cardiomyocyte1.22108661
45MP0001697_abnormal_embryo_size1.21444560
46MP0002088_abnormal_embryonic_growth/wei1.20991523
47MP0005394_taste/olfaction_phenotype1.20207512
48MP0005499_abnormal_olfactory_system1.20207512
49MP0002210_abnormal_sex_determination1.19992146
50MP0002166_altered_tumor_susceptibility1.18941403
51MP0005084_abnormal_gallbladder_morpholo1.06145370
52MP0002080_prenatal_lethality1.06124880
53MP0005379_endocrine/exocrine_gland_phen1.05879159
54MP0003938_abnormal_ear_development1.05034037
55MP0003763_abnormal_thymus_physiology1.03260380
56MP0003787_abnormal_imprinting0.95978753
57MP0002085_abnormal_embryonic_tissue0.94911415
58MP0002019_abnormal_tumor_incidence0.94605135
59MP0003699_abnormal_female_reproductive0.93890202
60MP0006036_abnormal_mitochondrial_physio0.87122634
61MP0001286_abnormal_eye_development0.86439661
62MP0003303_peritoneal_inflammation0.84392137
63MP0004510_myositis0.84217007
64MP0000733_abnormal_muscle_development0.83321648
65MP0003121_genomic_imprinting0.82713378
66MP0003315_abnormal_perineum_morphology0.82516958
67MP0000653_abnormal_sex_gland0.82343492
68MP0002234_abnormal_pharynx_morphology0.82150814
69MP0002092_abnormal_eye_morphology0.80493533
70MP0001145_abnormal_male_reproductive0.80398283
71MP0004197_abnormal_fetal_growth/weight/0.79935074
72MP0003300_gastrointestinal_ulcer0.79652992
73MP0000703_abnormal_thymus_morphology0.77890908
74MP0002161_abnormal_fertility/fecundity0.76701225
75MP0010307_abnormal_tumor_latency0.75381711
76MP0000613_abnormal_salivary_gland0.73728633
77MP0002233_abnormal_nose_morphology0.72841717
78MP0005645_abnormal_hypothalamus_physiol0.72709117
79MP0010234_abnormal_vibrissa_follicle0.72040088
80MP0002398_abnormal_bone_marrow0.69674768
81MP0009672_abnormal_birth_weight0.69530471
82MP0000749_muscle_degeneration0.68967224
83MP0002084_abnormal_developmental_patter0.67336618
84MP0002089_abnormal_postnatal_growth/wei0.67281121
85MP0005395_other_phenotype0.67257768
86MP0000358_abnormal_cell_content/0.64497031
87MP0003136_yellow_coat_color0.64051891
88MP0001119_abnormal_female_reproductive0.62089376
89MP0000566_synostosis0.61946125
90MP0002722_abnormal_immune_system0.60120107
91MP0002697_abnormal_eye_size0.57926668
92MP0002095_abnormal_skin_pigmentation0.56676839
93MP0008995_early_reproductive_senescence0.56523863
94MP0000689_abnormal_spleen_morphology0.56303498
95MP0001835_abnormal_antigen_presentation0.55456080
96MP0003698_abnormal_male_reproductive0.55251626
97MP0001800_abnormal_humoral_immune0.54888745
98MP0001919_abnormal_reproductive_system0.54390212
99MP0002106_abnormal_muscle_physiology0.54375937
100MP0000631_abnormal_neuroendocrine_gland0.53726736

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.34016751
2Colon cancer (HP:0003003)4.78004373
3Chromsome breakage (HP:0040012)4.16404366
4Abnormality of chromosome segregation (HP:0002916)3.92624724
5Abnormality of cells of the erythroid lineage (HP:0012130)3.81464345
6Septo-optic dysplasia (HP:0100842)3.65439468
7Hyperglycinemia (HP:0002154)3.62104368
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56666289
9Abnormal number of erythroid precursors (HP:0012131)3.50022120
10Increased hepatocellular lipid droplets (HP:0006565)3.44693556
11Macrocytic anemia (HP:0001972)3.31252611
12Nephroblastoma (Wilms tumor) (HP:0002667)2.99704586
13Rectovaginal fistula (HP:0000143)2.99136175
14Rectal fistula (HP:0100590)2.99136175
15Lipid accumulation in hepatocytes (HP:0006561)2.97032243
16Absent septum pellucidum (HP:0001331)2.94116236
17Impulsivity (HP:0100710)2.82198525
18Embryonal renal neoplasm (HP:0011794)2.76747217
19Abnormality of glycolysis (HP:0004366)2.73866425
20Abnormal lung lobation (HP:0002101)2.70339000
21Increased serum pyruvate (HP:0003542)2.69970859
22Birth length less than 3rd percentile (HP:0003561)2.68680311
23Hyperglycinuria (HP:0003108)2.65801636
24Gout (HP:0001997)2.64521722
25Abnormality of serine family amino acid metabolism (HP:0010894)2.63969186
26Abnormality of glycine metabolism (HP:0010895)2.63969186
27Abnormality of chromosome stability (HP:0003220)2.62941437
28Progressive external ophthalmoplegia (HP:0000590)2.60128484
29Intestinal fistula (HP:0100819)2.59446583
30Neoplasm of the colon (HP:0100273)2.58446828
31Vaginal fistula (HP:0004320)2.51787644
32Embryonal neoplasm (HP:0002898)2.47633986
33Abnormality of the labia minora (HP:0012880)2.47443960
34Decreased circulating renin level (HP:0003351)2.47115277
35Transitional cell carcinoma of the bladder (HP:0006740)2.43594311
36Increased nuchal translucency (HP:0010880)2.41152706
37Limb hypertonia (HP:0002509)2.39921373
38Thickened helices (HP:0000391)2.39321134
39Premature ovarian failure (HP:0008209)2.37877276
40Abnormality of the septum pellucidum (HP:0007375)2.36043384
41Microvesicular hepatic steatosis (HP:0001414)2.34746060
42IgM deficiency (HP:0002850)2.33763214
43Myelodysplasia (HP:0002863)2.33709816
44Progressive muscle weakness (HP:0003323)2.33450882
45Pallor (HP:0000980)2.28011025
46Small intestinal stenosis (HP:0012848)2.26113887
47Duodenal stenosis (HP:0100867)2.26113887
48Partial duplication of thumb phalanx (HP:0009944)2.25337056
49Hepatic necrosis (HP:0002605)2.23954893
50Trigonocephaly (HP:0000243)2.22828526
51Rhabdomyosarcoma (HP:0002859)2.20761609
52Bladder carcinoma (HP:0002862)2.19964260
53Bladder neoplasm (HP:0009725)2.19964260
54Abnormality of the ileum (HP:0001549)2.16750732
55Chronic sinusitis (HP:0011109)2.16249040
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14142651
57Increased CSF lactate (HP:0002490)2.13748642
58Abnormality of the anterior horn cell (HP:0006802)2.10577953
59Degeneration of anterior horn cells (HP:0002398)2.10577953
60Hypokinesia (HP:0002375)2.09768045
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07765298
62Uterine leiomyosarcoma (HP:0002891)2.07737251
63Leiomyosarcoma (HP:0100243)2.07737251
64Mitochondrial inheritance (HP:0001427)2.05825729
65Type I transferrin isoform profile (HP:0003642)2.05347128
66Meckel diverticulum (HP:0002245)2.05052261
67Supernumerary spleens (HP:0009799)2.02953633
68Pancytopenia (HP:0001876)2.02590463
69Impaired proprioception (HP:0010831)2.01882177
70Exertional dyspnea (HP:0002875)2.01006089
71Maternal diabetes (HP:0009800)1.98530567
72Abnormality of the duodenum (HP:0002246)1.96273226
73Acute encephalopathy (HP:0006846)1.93969310
74Increased serum lactate (HP:0002151)1.93136655
75Hepatocellular necrosis (HP:0001404)1.92648127
76Facial hemangioma (HP:0000329)1.92414992
77Broad palm (HP:0001169)1.91537818
78Horseshoe kidney (HP:0000085)1.91315654
79Triphalangeal thumb (HP:0001199)1.90693816
80Acute necrotizing encephalopathy (HP:0006965)1.90565499
81Duplication of thumb phalanx (HP:0009942)1.90067527
82Volvulus (HP:0002580)1.87508233
83Abnormality of the preputium (HP:0100587)1.86328922
84Generalized aminoaciduria (HP:0002909)1.85726764
85Enlarged penis (HP:0000040)1.84006793
86Progressive sensorineural hearing impairment (HP:0000408)1.83648424
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.83606762
88Oligodactyly (hands) (HP:0001180)1.83029037
89Malignant gastrointestinal tract tumors (HP:0006749)1.81956946
90Gastrointestinal carcinoma (HP:0002672)1.81956946
91Progressive hearing impairment (HP:0001730)1.81798817
9211 pairs of ribs (HP:0000878)1.80992579
93Abnormality of abdominal situs (HP:0011620)1.80483551
94Abdominal situs inversus (HP:0003363)1.80483551
95Partial duplication of the phalanx of hand (HP:0009999)1.79989784
96Increased intramyocellular lipid droplets (HP:0012240)1.79227099
97Abnormality of the pons (HP:0007361)1.78943215
98Abnormal ciliary motility (HP:0012262)1.78183198
99Abnormality of serum amino acid levels (HP:0003112)1.77705107
100Acute lymphatic leukemia (HP:0006721)1.76751445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.04911631
2VRK24.05075935
3CDC73.60409886
4ARAF3.15927486
5TAF13.03049835
6TTK2.94506864
7SMG12.69144999
8PASK2.47190800
9MAP3K132.35899511
10SRPK12.14045484
11TSSK62.13034245
12STK242.12132170
13NEK12.05729761
14VRK11.84722387
15CDK91.82196011
16MAP3K141.75908928
17CDK41.73865405
18STK101.71075702
19STK161.67513843
20NME21.61646475
21WEE11.61304593
22TIE11.59394873
23CHEK21.58242484
24PLK31.57634077
25MAP3K81.51980675
26MELK1.51077911
27MST41.47329648
28PLK11.40797952
29CDK121.31155648
30MAP3K91.30607831
31AURKA1.30170263
32AURKB1.29796573
33ZAK1.29483512
34BRAF1.26692398
35STK41.24115584
36EIF2AK31.24018155
37CDK31.22170926
38RPS6KB21.17794317
39TNIK1.17787261
40NEK21.13073592
41CDK71.11292124
42CDK81.09432070
43MKNK21.06585979
44MAP3K101.01521343
45CCNB11.00067999
46MAP4K10.99845003
47MKNK10.91978147
48CHEK10.90332971
49ATR0.86104155
50BCR0.85075115
51CLK10.83692406
52EIF2AK20.83446113
53PLK40.80124628
54MOS0.78768139
55CDK60.78526176
56NME10.75965753
57PAK10.74640437
58EEF2K0.73114125
59PIM20.71156804
60CDK11A0.65886441
61ALK0.65872160
62CDK150.65418771
63NUAK10.65275606
64EIF2AK10.63054316
65PAK40.62838309
66RAF10.60178172
67CDK180.59440851
68CDK20.59235939
69PBK0.57083682
70MAPKAPK50.54924038
71TGFBR10.54781488
72CDK10.54721108
73CDK140.53975452
74ATM0.53864115
75PIM10.53673794
76MATK0.52542696
77NLK0.50961405
78STK30.50098089
79MAP2K20.48265463
80PKN20.46549609
81DMPK0.45644443
82LATS20.44356461
83CSNK2A20.39560692
84CHUK0.38535667
85SCYL20.37871689
86CSNK2A10.37340820
87TRIM280.36613459
88PDK20.36579468
89DYRK30.36356096
90DDR20.35523005
91NEK90.32978361
92AKT20.31465501
93BRSK10.30843649
94IKBKB0.29086604
95DAPK10.27595675
96BMPR1B0.27129745
97LRRK20.27026683
98MAP3K50.25887407
99CSNK1G30.24159809
100TNK20.23880757

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.03311530
2DNA replication_Homo sapiens_hsa030304.29893268
3Mismatch repair_Homo sapiens_hsa034303.71046876
4Cell cycle_Homo sapiens_hsa041103.36756720
5Homologous recombination_Homo sapiens_hsa034403.34532097
6Proteasome_Homo sapiens_hsa030503.03009441
7Spliceosome_Homo sapiens_hsa030402.73832916
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66775269
9Base excision repair_Homo sapiens_hsa034102.64710994
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58589876
11One carbon pool by folate_Homo sapiens_hsa006702.47784606
12Nucleotide excision repair_Homo sapiens_hsa034202.36918920
13RNA transport_Homo sapiens_hsa030132.16581908
14Parkinsons disease_Homo sapiens_hsa050122.16286374
15Oxidative phosphorylation_Homo sapiens_hsa001902.11706764
16p53 signaling pathway_Homo sapiens_hsa041152.05534668
17RNA polymerase_Homo sapiens_hsa030201.95560940
18Basal transcription factors_Homo sapiens_hsa030221.92222704
19Fanconi anemia pathway_Homo sapiens_hsa034601.91901533
20RNA degradation_Homo sapiens_hsa030181.90808545
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80053357
22Huntingtons disease_Homo sapiens_hsa050161.67064368
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57804427
24Oocyte meiosis_Homo sapiens_hsa041141.53916727
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51026075
26Biosynthesis of amino acids_Homo sapiens_hsa012301.47930004
27Pyrimidine metabolism_Homo sapiens_hsa002401.46230187
28Epstein-Barr virus infection_Homo sapiens_hsa051691.44846661
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37552568
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37431276
31Non-homologous end-joining_Homo sapiens_hsa034501.30849083
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23408509
33Pentose phosphate pathway_Homo sapiens_hsa000301.23229840
34Selenocompound metabolism_Homo sapiens_hsa004501.22070488
35Alzheimers disease_Homo sapiens_hsa050101.10247597
36mRNA surveillance pathway_Homo sapiens_hsa030151.09473173
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00216692
38Purine metabolism_Homo sapiens_hsa002300.99719269
39Carbon metabolism_Homo sapiens_hsa012000.93323875
40Sulfur relay system_Homo sapiens_hsa041220.91237662
41Pyruvate metabolism_Homo sapiens_hsa006200.90696274
42Herpes simplex infection_Homo sapiens_hsa051680.90501285
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82947212
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81508903
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80995509
46Cardiac muscle contraction_Homo sapiens_hsa042600.80547480
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78530769
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78298187
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78070953
50HTLV-I infection_Homo sapiens_hsa051660.78017273
51Apoptosis_Homo sapiens_hsa042100.76861331
52Folate biosynthesis_Homo sapiens_hsa007900.70952790
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.66943969
54Viral carcinogenesis_Homo sapiens_hsa052030.62261239
55Antigen processing and presentation_Homo sapiens_hsa046120.60464586
56Small cell lung cancer_Homo sapiens_hsa052220.59012054
57Thyroid cancer_Homo sapiens_hsa052160.54538798
58Protein export_Homo sapiens_hsa030600.52819068
59Influenza A_Homo sapiens_hsa051640.52444401
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.49918036
61Allograft rejection_Homo sapiens_hsa053300.49230058
62Hepatitis B_Homo sapiens_hsa051610.47980694
63Pancreatic cancer_Homo sapiens_hsa052120.47379672
64Bladder cancer_Homo sapiens_hsa052190.44660756
65Primary immunodeficiency_Homo sapiens_hsa053400.44576438
66Colorectal cancer_Homo sapiens_hsa052100.42436375
67Arginine and proline metabolism_Homo sapiens_hsa003300.42257171
68Autoimmune thyroid disease_Homo sapiens_hsa053200.40011186
69Vitamin digestion and absorption_Homo sapiens_hsa049770.39597330
70Non-small cell lung cancer_Homo sapiens_hsa052230.37464657
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35901399
72TGF-beta signaling pathway_Homo sapiens_hsa043500.35746257
73Chronic myeloid leukemia_Homo sapiens_hsa052200.33067241
74Type I diabetes mellitus_Homo sapiens_hsa049400.32793590
75Prostate cancer_Homo sapiens_hsa052150.31410070
76Viral myocarditis_Homo sapiens_hsa054160.29214031
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27221265
78Metabolic pathways_Homo sapiens_hsa011000.25869898
79Phenylalanine metabolism_Homo sapiens_hsa003600.25294258
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.25145251
81Legionellosis_Homo sapiens_hsa051340.24856700
82Fatty acid elongation_Homo sapiens_hsa000620.23961935
83B cell receptor signaling pathway_Homo sapiens_hsa046620.22121295
84Caffeine metabolism_Homo sapiens_hsa002320.21941596
85Graft-versus-host disease_Homo sapiens_hsa053320.20369526
86Arginine biosynthesis_Homo sapiens_hsa002200.20062937
87Fructose and mannose metabolism_Homo sapiens_hsa000510.19675367
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.19099675
89Shigellosis_Homo sapiens_hsa051310.18937686
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18367989
91MicroRNAs in cancer_Homo sapiens_hsa052060.17084662
92Asthma_Homo sapiens_hsa053100.16007675
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15964159
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15604211
95Melanoma_Homo sapiens_hsa052180.14937838
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14710895
97Systemic lupus erythematosus_Homo sapiens_hsa053220.14392706
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13804830
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13413149
100Measles_Homo sapiens_hsa051620.13250877

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