SP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68694004
2negative regulation of cell killing (GO:0031342)4.68694004
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.43067204
4pyrimidine nucleobase catabolic process (GO:0006208)4.30631838
5regulation of rhodopsin mediated signaling pathway (GO:0022400)4.26710542
6rhodopsin mediated signaling pathway (GO:0016056)4.18719767
7protein localization to synapse (GO:0035418)4.12135845
8retinal cone cell development (GO:0046549)4.07891583
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.93520649
10retinal rod cell development (GO:0046548)3.92850249
11DNA double-strand break processing (GO:0000729)3.92783929
12layer formation in cerebral cortex (GO:0021819)3.84671172
13neuron cell-cell adhesion (GO:0007158)3.81909998
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.80041964
15regulation of mitotic spindle checkpoint (GO:1903504)3.80041964
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78346909
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71383793
18regulation of synaptic vesicle exocytosis (GO:2000300)3.65552181
19synaptic vesicle exocytosis (GO:0016079)3.62100346
20detection of light stimulus involved in sensory perception (GO:0050962)3.58871331
21detection of light stimulus involved in visual perception (GO:0050908)3.58871331
22photoreceptor cell maintenance (GO:0045494)3.50371090
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48295410
24histone H3-K4 trimethylation (GO:0080182)3.47316273
25photoreceptor cell development (GO:0042461)3.44655275
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.42089124
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.41186162
28regulation of translation, ncRNA-mediated (GO:0045974)3.41186162
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41186162
30vocalization behavior (GO:0071625)3.40795482
31cerebellar Purkinje cell differentiation (GO:0021702)3.40297245
32eye photoreceptor cell development (GO:0042462)3.34666755
33nucleobase catabolic process (GO:0046113)3.34542410
34negative regulation of DNA recombination (GO:0045910)3.31255526
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.30868373
36DNA deamination (GO:0045006)3.28819574
37positive regulation of dendritic spine morphogenesis (GO:0061003)3.27715804
38glutamate receptor signaling pathway (GO:0007215)3.25727576
39neural tube formation (GO:0001841)3.25397095
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.20781238
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20781238
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20582824
43positive regulation of synapse maturation (GO:0090129)3.20301059
44dendritic spine morphogenesis (GO:0060997)3.18531372
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16268639
46positive T cell selection (GO:0043368)3.14897847
47cellular potassium ion homeostasis (GO:0030007)3.14341847
48neurotransmitter-gated ion channel clustering (GO:0072578)3.13804535
49locomotory exploration behavior (GO:0035641)3.12914022
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.12108444
51regulation of glutamate receptor signaling pathway (GO:1900449)3.12064726
52presynaptic membrane assembly (GO:0097105)3.09369857
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07691246
54long-term synaptic potentiation (GO:0060291)3.05442160
55protein K11-linked deubiquitination (GO:0035871)3.04873675
56resolution of meiotic recombination intermediates (GO:0000712)3.03381137
57synaptic vesicle maturation (GO:0016188)3.03140735
58preassembly of GPI anchor in ER membrane (GO:0016254)3.00898898
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00653447
60protein polyglutamylation (GO:0018095)3.00251722
61cardiac ventricle formation (GO:0003211)2.98168909
62replication fork processing (GO:0031297)2.97706490
63negative T cell selection (GO:0043383)2.97046927
64response to histamine (GO:0034776)2.96829824
65regulation of synaptic vesicle transport (GO:1902803)2.96510612
66fucose catabolic process (GO:0019317)2.96123721
67L-fucose metabolic process (GO:0042354)2.96123721
68L-fucose catabolic process (GO:0042355)2.96123721
69regulation of DNA endoreduplication (GO:0032875)2.95708275
70heart field specification (GO:0003128)2.89441949
71secondary heart field specification (GO:0003139)2.89441949
72neuron recognition (GO:0008038)2.87576581
73positive regulation of membrane potential (GO:0045838)2.87396521
74chromatin remodeling at centromere (GO:0031055)2.87340317
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85771567
76isotype switching (GO:0045190)2.85771567
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85771567
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85401110
79respiratory chain complex IV assembly (GO:0008535)2.85372519
80positive regulation of mRNA processing (GO:0050685)2.84011261
81activated T cell proliferation (GO:0050798)2.83225673
82histone H2A acetylation (GO:0043968)2.82141120
83glutamate secretion (GO:0014047)2.81594701
84neuron-neuron synaptic transmission (GO:0007270)2.81274434
85synapsis (GO:0007129)2.80783472
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78918906
87positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.78621370
88regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.78621370
89long-term memory (GO:0007616)2.77977479
90piRNA metabolic process (GO:0034587)2.77704023
91positive regulation of gamma-delta T cell activation (GO:0046645)2.77376206
92central nervous system projection neuron axonogenesis (GO:0021952)2.77226208
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77079801
94startle response (GO:0001964)2.76772689
95dendrite morphogenesis (GO:0048813)2.76501165
96regulation of postsynaptic membrane potential (GO:0060078)2.76461822
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76370907
98synaptic transmission, glutamatergic (GO:0035249)2.75986266
99activation of protein kinase A activity (GO:0034199)2.75619429
100negative thymic T cell selection (GO:0045060)2.74669605
101exploration behavior (GO:0035640)2.74573734
102single strand break repair (GO:0000012)2.73726318
103behavioral response to nicotine (GO:0035095)2.73709386
104regulation of synaptic transmission, glutamatergic (GO:0051966)2.72999882
105CENP-A containing nucleosome assembly (GO:0034080)2.72940812
106GPI anchor metabolic process (GO:0006505)2.72505631
107negative regulation of histone methylation (GO:0031061)2.72396486
108T cell selection (GO:0045058)2.71801206
109regulation of telomere maintenance (GO:0032204)2.71533025
110regulation of dendritic spine morphogenesis (GO:0061001)2.70927299
111behavioral fear response (GO:0001662)2.70845381
112behavioral defense response (GO:0002209)2.70845381
113regulation of ARF protein signal transduction (GO:0032012)2.69381636
114DNA demethylation (GO:0080111)2.69200077
115regulation of NFAT protein import into nucleus (GO:0051532)2.69146795
116presynaptic membrane organization (GO:0097090)2.68950844
117positive regulation of histone H3-K4 methylation (GO:0051571)2.68276109
118protein K6-linked ubiquitination (GO:0085020)2.67512718
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.67236165
120establishment of nucleus localization (GO:0040023)2.66671045
121positive regulation of mRNA metabolic process (GO:1903313)2.66050621
122recombinational repair (GO:0000725)2.65149275
123regulation of neurotransmitter secretion (GO:0046928)2.65061214
124axonal fasciculation (GO:0007413)2.65023517
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.64600580
126peptidyl-lysine trimethylation (GO:0018023)2.63456646
127negative regulation of telomere maintenance (GO:0032205)2.63289574
128double-strand break repair via homologous recombination (GO:0000724)2.62677451
129kidney morphogenesis (GO:0060993)2.60894005
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60836757
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58790092
132cardiac chamber formation (GO:0003207)2.57849254
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57512776
134regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.57361581
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.57361581
136vesicle transport along microtubule (GO:0047496)2.57357282
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.57030100
138histone exchange (GO:0043486)2.56661154
139neurotransmitter secretion (GO:0007269)2.56275491
140somite rostral/caudal axis specification (GO:0032525)2.55838983
141microtubule depolymerization (GO:0007019)2.54708366
142nonmotile primary cilium assembly (GO:0035058)2.54268905
143microtubule anchoring (GO:0034453)2.52791569
144tachykinin receptor signaling pathway (GO:0007217)2.52707145
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52217738
146membrane hyperpolarization (GO:0060081)2.51392509
147positive regulation of CREB transcription factor activity (GO:0032793)2.49854234
148regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.49187098
149positive regulation of mRNA catabolic process (GO:0061014)2.48926898
150reciprocal meiotic recombination (GO:0007131)2.48474510
151reciprocal DNA recombination (GO:0035825)2.48474510
152sensory perception of smell (GO:0007608)2.48302839
153DNA damage response, detection of DNA damage (GO:0042769)2.47738574
154mRNA splice site selection (GO:0006376)2.46686941
155sodium ion export (GO:0071436)2.46471768
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.46346778
157cellular response to interleukin-15 (GO:0071350)2.46338910
158olfactory bulb development (GO:0021772)2.46119100
159interferon-gamma production (GO:0032609)2.45782906
160synaptic vesicle endocytosis (GO:0048488)2.45738796
161striatum development (GO:0021756)2.44979435
162prepulse inhibition (GO:0060134)2.44562220
163regulation of voltage-gated calcium channel activity (GO:1901385)2.44064743
164fear response (GO:0042596)2.43918795
165DNA replication-dependent nucleosome assembly (GO:0006335)2.43169194
166DNA replication-dependent nucleosome organization (GO:0034723)2.43169194
167mechanosensory behavior (GO:0007638)2.42967381
168nucleosome disassembly (GO:0006337)2.42468453
169protein-DNA complex disassembly (GO:0032986)2.42468453
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41441221
171protein-cofactor linkage (GO:0018065)2.40072622
172response to pheromone (GO:0019236)2.39932318
173regulation of action potential (GO:0098900)2.38890321
174establishment of protein localization to Golgi (GO:0072600)2.38729384
175regulation of meiosis I (GO:0060631)2.38634752
176negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37715635
177regulation of mRNA 3-end processing (GO:0031440)2.37478264
178platelet dense granule organization (GO:0060155)2.37471846
179cytochrome complex assembly (GO:0017004)2.37428769
180positive regulation of mRNA 3-end processing (GO:0031442)2.36951875
181histone mRNA metabolic process (GO:0008334)2.36710987
182detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36686532
183somatic diversification of immune receptors (GO:0002200)2.35531854
184negative regulation of JUN kinase activity (GO:0043508)2.35327704
185GPI anchor biosynthetic process (GO:0006506)2.34745578
186RNA destabilization (GO:0050779)2.34473183
187regulation of helicase activity (GO:0051095)2.32980010
188positive regulation of action potential (GO:0045760)2.32144841
189cilium morphogenesis (GO:0060271)2.31831210
190attachment of spindle microtubules to kinetochore (GO:0008608)2.31435939
191somatic diversification of immunoglobulins (GO:0016445)2.30525622
192positive regulation of amino acid transport (GO:0051957)2.30211490
193DNA catabolic process, exonucleolytic (GO:0000738)2.29562489
194somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.29444326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.64606942
2GBX2_23144817_ChIP-Seq_PC3_Human3.36724257
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26009154
4IGF1R_20145208_ChIP-Seq_DFB_Human2.97422490
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91757140
6VDR_22108803_ChIP-Seq_LS180_Human2.71111467
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58250583
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.49457690
9AR_21572438_ChIP-Seq_LNCaP_Human2.48268920
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36024136
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30912464
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30548716
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26868189
14DROSHA_22980978_ChIP-Seq_HELA_Human2.21369533
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18581461
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16765637
17TAF15_26573619_Chip-Seq_HEK293_Human2.14608305
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14478999
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11122676
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.08520547
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08453174
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.07748400
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06991762
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.06746129
25REST_21632747_ChIP-Seq_MESCs_Mouse2.02311607
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99223705
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98185277
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93954984
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93728398
30ELK1_19687146_ChIP-ChIP_HELA_Human1.91497781
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.88451295
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87546464
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86910748
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81509236
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.81109188
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80736270
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80736270
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79887646
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77008709
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76936442
41RUNX_20019798_ChIP-Seq_JUKART_Human1.76669491
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.74343937
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.74096346
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73913312
45SMAD4_21799915_ChIP-Seq_A2780_Human1.72023905
46VDR_23849224_ChIP-Seq_CD4+_Human1.68656457
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66075452
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63184335
49* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59958349
50* P300_19829295_ChIP-Seq_ESCs_Human1.58973247
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58859907
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.56664624
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56263064
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54902904
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54592073
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51262368
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.50686314
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48909781
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.48532362
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47255143
61* REST_18959480_ChIP-ChIP_MESCs_Mouse1.47087498
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46159424
63MYC_18940864_ChIP-ChIP_HL60_Human1.46079341
64STAT3_23295773_ChIP-Seq_U87_Human1.45756437
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.45680831
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43943989
67FUS_26573619_Chip-Seq_HEK293_Human1.43250764
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42829693
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42829693
70RNF2_27304074_Chip-Seq_NSC_Mouse1.40955030
71IRF1_19129219_ChIP-ChIP_H3396_Human1.40507946
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40493855
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40305213
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.40079492
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.39255129
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38332982
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37761766
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37105716
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36392731
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36246046
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36205545
82TCF4_23295773_ChIP-Seq_U87_Human1.35606191
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.34602730
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.33894767
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32057658
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31589287
87* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29525174
88CBP_20019798_ChIP-Seq_JUKART_Human1.28967693
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28967693
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.28461718
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27202888
92* AR_19668381_ChIP-Seq_PC3_Human1.26069306
93WDR5_24793694_ChIP-Seq_LNCAP_Human1.25246856
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24080796
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23662092
96E2F7_22180533_ChIP-Seq_HELA_Human1.22967879
97AR_25329375_ChIP-Seq_VCAP_Human1.22812868
98FOXP3_21729870_ChIP-Seq_TREG_Human1.22679107
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.21447781
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21369667
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20242898
102* CBX2_27304074_Chip-Seq_ESCs_Mouse1.20122817
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18448692
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18380256
105P53_22387025_ChIP-Seq_ESCs_Mouse1.18117232
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17928945
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17297286
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16237056
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15483179
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.14635944
111TP53_22573176_ChIP-Seq_HFKS_Human1.13820001
112TP53_16413492_ChIP-PET_HCT116_Human1.13799736
113* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13749833
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13684501
115TCF4_22108803_ChIP-Seq_LS180_Human1.13670155
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12925095
117* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12892597
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12768561
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12481712
120ER_23166858_ChIP-Seq_MCF-7_Human1.12455789
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12282285
122* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12211768
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10805496
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10384412
125ZNF274_21170338_ChIP-Seq_K562_Hela1.10230132
126BCAT_22108803_ChIP-Seq_LS180_Human1.09702542
127* SOX2_16153702_ChIP-ChIP_HESCs_Human1.08988572
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08660689
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08094523
130P300_18555785_Chip-Seq_ESCs_Mouse1.07683963
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06881908
132NANOG_19829295_ChIP-Seq_ESCs_Human1.06685936
133SOX2_19829295_ChIP-Seq_ESCs_Human1.06685936
134AHR_22903824_ChIP-Seq_MCF-7_Human1.06091413
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05734298
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05041385
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.04621897
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.04235449
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04221617
140RING1B_27294783_Chip-Seq_ESCs_Mouse1.04132544
141NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04010944
142E2F1_18555785_Chip-Seq_ESCs_Mouse1.03898694
143KDM2B_26808549_Chip-Seq_JURKAT_Human1.03675628
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.02905284
145* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02412887
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02376297
147EWS_26573619_Chip-Seq_HEK293_Human1.02243800
148KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02193930
149IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01716529
150NANOG_18555785_Chip-Seq_ESCs_Mouse1.00907075
151OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00663245
152RUNX2_22187159_ChIP-Seq_PCA_Human1.00459836
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95959828
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95488661
155KDM2B_26808549_Chip-Seq_K562_Human0.95353984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.04595615
2MP0006072_abnormal_retinal_apoptosis3.53264933
3MP0004859_abnormal_synaptic_plasticity3.39101742
4MP0002102_abnormal_ear_morphology3.28168605
5MP0005423_abnormal_somatic_nervous3.18263596
6MP0003880_abnormal_central_pattern3.11427139
7MP0008057_abnormal_DNA_replication3.01772744
8MP0008058_abnormal_DNA_repair3.01750349
9MP0003635_abnormal_synaptic_transmissio2.95830298
10MP0005253_abnormal_eye_physiology2.80193316
11MP0001984_abnormal_olfaction2.58424726
12MP0009745_abnormal_behavioral_response2.42961452
13* MP0002063_abnormal_learning/memory/cond2.39692697
14MP0004270_analgesia2.38663236
15MP0003787_abnormal_imprinting2.36832958
16MP0002064_seizures2.33698558
17MP0010094_abnormal_chromosome_stability2.20313008
18MP0000778_abnormal_nervous_system2.19878582
19* MP0001486_abnormal_startle_reflex2.17914916
20* MP0002572_abnormal_emotion/affect_behav2.01309447
21MP0009046_muscle_twitch1.99490074
22MP0004885_abnormal_endolymph1.98478021
23MP0002184_abnormal_innervation1.93572580
24MP0002138_abnormal_hepatobiliary_system1.93046669
25MP0005499_abnormal_olfactory_system1.81843253
26MP0005394_taste/olfaction_phenotype1.81843253
27MP0002272_abnormal_nervous_system1.81516124
28MP0002067_abnormal_sensory_capabilities1.79350237
29MP0008569_lethality_at_weaning1.79050508
30MP0002009_preneoplasia1.77027740
31MP0003890_abnormal_embryonic-extraembry1.76678563
32MP0001968_abnormal_touch/_nociception1.76061873
33MP0003011_delayed_dark_adaptation1.74362704
34MP0001502_abnormal_circadian_rhythm1.71939302
35MP0005084_abnormal_gallbladder_morpholo1.68341168
36MP0006292_abnormal_olfactory_placode1.68284688
37MP0005386_behavior/neurological_phenoty1.68138990
38MP0004924_abnormal_behavior1.68138990
39MP0008877_abnormal_DNA_methylation1.68022773
40MP0005075_abnormal_melanosome_morpholog1.66506104
41MP0005195_abnormal_posterior_eye1.66266765
42MP0005646_abnormal_pituitary_gland1.64696009
43MP0002734_abnormal_mechanical_nocicepti1.64173847
44MP0008961_abnormal_basal_metabolism1.63888482
45MP0004742_abnormal_vestibular_system1.58036054
46MP0003121_genomic_imprinting1.52825015
47MP0002882_abnormal_neuron_morphology1.52015783
48MP0001501_abnormal_sleep_pattern1.50173827
49MP0002653_abnormal_ependyma_morphology1.48915418
50MP0002822_catalepsy1.47409045
51* MP0002557_abnormal_social/conspecific_i1.46387652
52MP0002229_neurodegeneration1.44005067
53MP0000372_irregular_coat_pigmentation1.43751231
54MP0008995_early_reproductive_senescence1.42005696
55MP0000631_abnormal_neuroendocrine_gland1.39505443
56MP0004811_abnormal_neuron_physiology1.39051376
57MP0003763_abnormal_thymus_physiology1.38418916
58MP0008789_abnormal_olfactory_epithelium1.36795544
59MP0005391_vision/eye_phenotype1.35185568
60MP0005187_abnormal_penis_morphology1.33999541
61MP0002752_abnormal_somatic_nervous1.33957497
62MP0002735_abnormal_chemical_nociception1.32005099
63MP0002638_abnormal_pupillary_reflex1.31731495
64MP0000569_abnormal_digit_pigmentation1.28313589
65MP0003693_abnormal_embryo_hatching1.25707699
66MP0002090_abnormal_vision1.25082815
67MP0003567_abnormal_fetal_cardiomyocyte1.22420743
68MP0002277_abnormal_respiratory_mucosa1.22148334
69MP0002166_altered_tumor_susceptibility1.21544422
70MP0000427_abnormal_hair_cycle1.20886920
71MP0005671_abnormal_response_to1.19891485
72MP0002254_reproductive_system_inflammat1.19783053
73* MP0002152_abnormal_brain_morphology1.15554202
74MP0003786_premature_aging1.14267261
75MP0002837_dystrophic_cardiac_calcinosis1.14092124
76MP0003119_abnormal_digestive_system1.13990068
77MP0001970_abnormal_pain_threshold1.12000827
78MP0004133_heterotaxia1.11415387
79MP0001440_abnormal_grooming_behavior1.11107615
80MP0006035_abnormal_mitochondrial_morpho1.09259626
81MP0005645_abnormal_hypothalamus_physiol1.09093609
82MP0002733_abnormal_thermal_nociception1.07377286
83MP0003718_maternal_effect1.06360147
84MP0004142_abnormal_muscle_tone1.05520650
85MP0001293_anophthalmia1.05474376
86MP0001929_abnormal_gametogenesis1.04080779
87* MP0000703_abnormal_thymus_morphology1.03458595
88MP0000955_abnormal_spinal_cord1.02932270
89MP0002736_abnormal_nociception_after1.02467487
90MP0003633_abnormal_nervous_system1.01614036
91MP0002234_abnormal_pharynx_morphology1.01453475
92MP0003195_calcinosis0.99348613
93MP0008872_abnormal_physiological_respon0.97668264
94* MP0002066_abnormal_motor_capabilities/c0.96780833
95MP0002938_white_spotting0.95412676
96* MP0002210_abnormal_sex_determination0.95180467
97MP0005409_darkened_coat_color0.95131824
98MP0001188_hyperpigmentation0.94324664
99MP0004043_abnormal_pH_regulation0.94228414
100* MP0003698_abnormal_male_reproductive0.93177262
101MP0003861_abnormal_nervous_system0.90326349
102MP0003111_abnormal_nucleus_morphology0.88287636
103MP0003077_abnormal_cell_cycle0.88116921
104* MP0000653_abnormal_sex_gland0.87728238
105MP0001529_abnormal_vocalization0.87522453
106MP0001919_abnormal_reproductive_system0.86993174
107MP0003183_abnormal_peptide_metabolism0.86348368
108* MP0001145_abnormal_male_reproductive0.85851857
109MP0005367_renal/urinary_system_phenotyp0.85671374
110MP0000516_abnormal_urinary_system0.85671374
111MP0000647_abnormal_sebaceous_gland0.84995879
112MP0001963_abnormal_hearing_physiology0.84862788
113MP0001324_abnormal_eye_pigmentation0.84474526
114MP0002095_abnormal_skin_pigmentation0.82984340
115MP0005174_abnormal_tail_pigmentation0.82712429
116MP0004957_abnormal_blastocyst_morpholog0.82504188
117MP0006276_abnormal_autonomic_nervous0.79495128
118MP0003303_peritoneal_inflammation0.79035110
119MP0003937_abnormal_limbs/digits/tail_de0.78881275
120MP0003646_muscle_fatigue0.78598195
121MP0003136_yellow_coat_color0.77745218
122MP0009780_abnormal_chondrocyte_physiolo0.77313121
123MP0010386_abnormal_urinary_bladder0.77011944
124MP0002398_abnormal_bone_marrow0.76957538
125MP0003122_maternal_imprinting0.76550231
126MP0001986_abnormal_taste_sensitivity0.76352267
127MP0001286_abnormal_eye_development0.75903282
128MP0010234_abnormal_vibrissa_follicle0.74778283
129MP0002006_tumorigenesis0.74461466
130MP0003866_abnormal_defecation0.71977532
131MP0001800_abnormal_humoral_immune0.71128910
132MP0000015_abnormal_ear_pigmentation0.70953148
133MP0002909_abnormal_adrenal_gland0.69426493
134MP0003631_nervous_system_phenotype0.67932838
135MP0010769_abnormal_survival0.64057855
136MP0010768_mortality/aging0.61835362
137MP0004215_abnormal_myocardial_fiber0.61633002
138MP0004233_abnormal_muscle_weight0.61250353
139* MP0002082_postnatal_lethality0.61192458
140* MP0010770_preweaning_lethality0.61192458
141* MP0003634_abnormal_glial_cell0.59504396
142MP0003879_abnormal_hair_cell0.59018414
143MP0001873_stomach_inflammation0.58922178
144MP0002751_abnormal_autonomic_nervous0.57318211
145MP0004808_abnormal_hematopoietic_stem0.56742037
146MP0001485_abnormal_pinna_reflex0.55956801

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.84679669
2Bony spicule pigmentary retinopathy (HP:0007737)5.09502320
3Abnormal rod and cone electroretinograms (HP:0008323)4.20020480
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.09694819
5Central scotoma (HP:0000603)3.88418865
6Abnormality of macular pigmentation (HP:0008002)3.76337794
7Pancreatic cysts (HP:0001737)3.42236248
8Colon cancer (HP:0003003)3.38481813
9Volvulus (HP:0002580)3.36250960
10Focal motor seizures (HP:0011153)3.28479521
11Abnormality of the labia minora (HP:0012880)3.24887482
12Protruding tongue (HP:0010808)3.21901339
13Scotoma (HP:0000575)3.16387673
14Aqueductal stenosis (HP:0002410)3.13733552
15Atonic seizures (HP:0010819)3.09136638
16Epileptic encephalopathy (HP:0200134)3.00836894
17Broad-based gait (HP:0002136)2.99739804
18Pendular nystagmus (HP:0012043)2.99370434
19Hyperventilation (HP:0002883)2.94997791
20Febrile seizures (HP:0002373)2.92725445
21Pancreatic fibrosis (HP:0100732)2.90596377
22Molar tooth sign on MRI (HP:0002419)2.85252250
23Abnormality of midbrain morphology (HP:0002418)2.85252250
24Dyschromatopsia (HP:0007641)2.84069745
25Attenuation of retinal blood vessels (HP:0007843)2.80063716
26Drooling (HP:0002307)2.79108316
27Excessive salivation (HP:0003781)2.79108316
28Focal seizures (HP:0007359)2.77830963
29Progressive cerebellar ataxia (HP:0002073)2.76630053
30Nephronophthisis (HP:0000090)2.72005426
31Macroorchidism (HP:0000053)2.70497516
32Intestinal atresia (HP:0011100)2.70420440
33Truncal ataxia (HP:0002078)2.69800910
34Type II diabetes mellitus (HP:0005978)2.69049573
35Chorioretinal atrophy (HP:0000533)2.68419292
36Renal cortical cysts (HP:0000803)2.67098659
37Absence seizures (HP:0002121)2.65742936
38True hermaphroditism (HP:0010459)2.65549842
39Abnormality of the renal cortex (HP:0011035)2.65210043
40Inappropriate behavior (HP:0000719)2.57419968
41Decreased central vision (HP:0007663)2.55203128
42Severe visual impairment (HP:0001141)2.53646366
43Abnormality of the fingertips (HP:0001211)2.52263036
44Constricted visual fields (HP:0001133)2.47728119
45Facial hemangioma (HP:0000329)2.44696714
46Widely spaced teeth (HP:0000687)2.43775081
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.43071477
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43071477
49Tubulointerstitial nephritis (HP:0001970)2.42911556
50Abolished electroretinogram (ERG) (HP:0000550)2.42742230
51Visual hallucinations (HP:0002367)2.41391891
52Photophobia (HP:0000613)2.40643019
53Thyroiditis (HP:0100646)2.35232586
54Abnormality of the renal medulla (HP:0100957)2.34194434
55Gait imbalance (HP:0002141)2.32303205
56Chronic hepatic failure (HP:0100626)2.31718556
57Pigmentary retinal degeneration (HP:0001146)2.29838360
58Abnormality of chromosome stability (HP:0003220)2.29502135
59Progressive inability to walk (HP:0002505)2.26501206
60Dialeptic seizures (HP:0011146)2.22573288
61Severe combined immunodeficiency (HP:0004430)2.20149237
62Genetic anticipation (HP:0003743)2.19731421
63Blue irides (HP:0000635)2.19209536
64Lissencephaly (HP:0001339)2.19115579
65Meckel diverticulum (HP:0002245)2.17352224
66Abnormality of the ileum (HP:0001549)2.14575474
67Methylmalonic acidemia (HP:0002912)2.11707021
68Absent speech (HP:0001344)2.09709152
69T lymphocytopenia (HP:0005403)2.09706205
70Inability to walk (HP:0002540)2.06581004
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.05981897
72Posterior subcapsular cataract (HP:0007787)2.05897246
73Abnormality of the pons (HP:0007361)2.05802494
74IgG deficiency (HP:0004315)2.05344774
75Bile duct proliferation (HP:0001408)2.05108354
76Abnormal biliary tract physiology (HP:0012439)2.05108354
77Stomach cancer (HP:0012126)2.01764334
78Depression (HP:0000716)2.01175074
79Retinitis pigmentosa (HP:0000510)2.01133050
80Impaired smooth pursuit (HP:0007772)2.00416056
81Hypoplasia of the pons (HP:0012110)1.99972761
82Epileptiform EEG discharges (HP:0011182)1.99971356
83Supernumerary spleens (HP:0009799)1.99969895
84Congenital primary aphakia (HP:0007707)1.99619306
85Exotropia (HP:0000577)1.97563357
86Gaze-evoked nystagmus (HP:0000640)1.97495720
87Pachygyria (HP:0001302)1.95975077
88EEG with generalized epileptiform discharges (HP:0011198)1.95110690
89Agitation (HP:0000713)1.94357735
90Obsessive-compulsive behavior (HP:0000722)1.94345988
91Ependymoma (HP:0002888)1.93698813
92Neoplasm of the adrenal cortex (HP:0100641)1.93547195
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.90652974
94Fair hair (HP:0002286)1.89870888
95Scanning speech (HP:0002168)1.89227484
96Abnormality of salivation (HP:0100755)1.89154410
97Increased density of long bones (HP:0006392)1.88495352
98Tented upper lip vermilion (HP:0010804)1.88218736
99Abnormality of the intervertebral disk (HP:0005108)1.88090366
100Hypochromic microcytic anemia (HP:0004840)1.87801609
101Abnormality of the corticospinal tract (HP:0002492)1.86835163
102Failure to thrive in infancy (HP:0001531)1.86429343
103Trigonocephaly (HP:0000243)1.85815079
104Abnormality of binocular vision (HP:0011514)1.85267177
105Diplopia (HP:0000651)1.85267177
106Hypothermia (HP:0002045)1.84240633
107Combined immunodeficiency (HP:0005387)1.83469987
108Abnormality of T cell number (HP:0011839)1.83308730
109Glioma (HP:0009733)1.82451632
110Truncal obesity (HP:0001956)1.82125753
111Choroideremia (HP:0001139)1.81868254
112Poor eye contact (HP:0000817)1.81591721
113Vitreoretinal degeneration (HP:0000655)1.81505683
114Oligodactyly (hands) (HP:0001180)1.81011451
115Genital tract atresia (HP:0001827)1.80287004
116Macular degeneration (HP:0000608)1.80245552
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79781166
118Chromsome breakage (HP:0040012)1.78862130
119Sloping forehead (HP:0000340)1.78164772
120Urinary urgency (HP:0000012)1.77901047
121Clubbing of toes (HP:0100760)1.77777052
122Clumsiness (HP:0002312)1.77483056
123Heterotopia (HP:0002282)1.77460999
124Nephrogenic diabetes insipidus (HP:0009806)1.75313111
125Medial flaring of the eyebrow (HP:0010747)1.74499838
126Cone-rod dystrophy (HP:0000548)1.74363910
127Dysmetric saccades (HP:0000641)1.74082180
128Dysdiadochokinesis (HP:0002075)1.74007743
129Cutis marmorata (HP:0000965)1.73917734
130Stereotypic behavior (HP:0000733)1.73650840
131Short 4th metacarpal (HP:0010044)1.73624052
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73624052
133Generalized hypopigmentation of hair (HP:0011358)1.72708450
134Dandy-Walker malformation (HP:0001305)1.72187993
135Abnormality of ocular smooth pursuit (HP:0000617)1.70995019
136Narrow forehead (HP:0000341)1.70361940
137Hypsarrhythmia (HP:0002521)1.70344830
138Vaginal atresia (HP:0000148)1.69854185
139Abnormal hair whorl (HP:0010721)1.69670513
140Sclerocornea (HP:0000647)1.69399187
141Open mouth (HP:0000194)1.68998225
142Increased corneal curvature (HP:0100692)1.68726079
143Keratoconus (HP:0000563)1.68726079
144Short tibia (HP:0005736)1.68693144
145Impaired social interactions (HP:0000735)1.68502811
146Abnormal social behavior (HP:0012433)1.68502811
147Medulloblastoma (HP:0002885)1.67952307
148Generalized tonic-clonic seizures (HP:0002069)1.66899056
149Thyroid-stimulating hormone excess (HP:0002925)1.66457267
150Anencephaly (HP:0002323)1.66254895
151Urinary bladder sphincter dysfunction (HP:0002839)1.66001788
152Abnormality of the metopic suture (HP:0005556)1.65564723
153Narrow palate (HP:0000189)1.64995887
154Autism (HP:0000717)1.64976828
155Gastrointestinal atresia (HP:0002589)1.64350227
156Myokymia (HP:0002411)1.63900917
157Amyotrophic lateral sclerosis (HP:0007354)1.63644220
158Abnormal lung lobation (HP:0002101)1.63630944
159Lipid accumulation in hepatocytes (HP:0006561)1.63621739
160Hemiparesis (HP:0001269)1.63388828
161Methylmalonic aciduria (HP:0012120)1.62854437
162Increased CSF lactate (HP:0002490)1.61641564
163Abnormality of the astrocytes (HP:0100707)1.61430379
164Astrocytoma (HP:0009592)1.61430379
165B lymphocytopenia (HP:0010976)1.60343327
166Increased hepatocellular lipid droplets (HP:0006565)1.60287960
167Abnormality of the duodenum (HP:0002246)1.58920892
168Small intestinal stenosis (HP:0012848)1.58504461
169Duodenal stenosis (HP:0100867)1.58504461
170Impaired vibration sensation in the lower limbs (HP:0002166)1.57960195
171Postaxial foot polydactyly (HP:0001830)1.57785626
172Abnormality of the fovea (HP:0000493)1.57287648
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.57277802
174Aplasia/hypoplasia of the uterus (HP:0008684)1.57054217
175Hyperglycinemia (HP:0002154)1.56679412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.54188263
2MAP4K23.53473192
3MARK13.16839468
4CAMK1G2.50501813
5TRIM282.50470332
6PNCK2.48798957
7FGFR22.41263913
8SIK22.39997086
9ZAK2.25821129
10CASK2.20476958
11NUAK12.18777003
12MKNK12.13815406
13TXK2.07789603
14MAP2K72.03881719
15NTRK22.02339768
16BRD41.92716809
17BCR1.89469552
18PASK1.73820793
19SRPK11.65755062
20EIF2AK31.64606273
21CAMKK11.59642829
22MAPK131.59546365
23NTRK31.52454474
24PLK41.50302534
25ERBB31.49131064
26BUB11.48543229
27SGK21.48221947
28CAMK1D1.46635930
29FGFR31.45328563
30TNIK1.44657562
31FES1.41755279
32MAP4K11.40926692
33CDK121.38342536
34EPHA41.36698203
35PAK61.36006146
36WNK11.35435996
37DYRK21.31739858
38SGK31.31710803
39CSNK1G11.29221774
40MAP2K41.28232680
41BRSK21.26308969
42DYRK1A1.26222585
43MST41.25889005
44KSR11.25858545
45ITK1.25538769
46NLK1.25207416
47PRPF4B1.24501973
48RPS6KA41.21913635
49SGK2231.21080025
50SGK4941.21080025
51TSSK61.19086058
52CAMKK21.18363607
53ACVR1B1.16134437
54DAPK21.15510054
55MAP3K61.13604764
56PLK31.12675624
57UHMK11.09968031
58STK111.09448863
59ADRBK21.08860251
60GRK61.07352801
61DYRK31.06828458
62TYRO31.04686230
63CSNK1G31.03716910
64MAP3K101.03052755
65PINK11.01402490
66FRK1.00010524
67PRKCH0.97022671
68VRK10.96299795
69MAPK70.95888015
70SIK30.95265455
71CDK30.93514127
72MINK10.93140307
73CDK50.91788745
74TAF10.91529870
75PAK30.91039096
76OXSR10.90847451
77MARK20.89521360
78SGK10.86013199
79TLK10.83946234
80GRK10.83333803
81CCNB10.82029293
82SCYL20.82012928
83PHKG10.81642862
84PHKG20.81642862
85MKNK20.81401717
86HIPK20.80470070
87RET0.79340573
88WEE10.79156373
89CDC70.73793134
90STK390.73746272
91CAMK2B0.71226644
92CDK90.71114276
93PKN10.70363572
94PRKCG0.70270345
95BMPR1B0.69536743
96ATR0.69480940
97TGFBR10.69277384
98GRK70.68314784
99RIPK40.68301157
100RPS6KA50.68258288
101PLK10.67844175
102STK160.67523057
103CDK190.67412180
104CAMK10.66302045
105STK38L0.66269453
106CSNK1A1L0.66150731
107PLK20.65765812
108WNK30.65662198
109CAMK40.65346258
110WNK40.65288036
111TEC0.64437729
112CSNK1G20.63068592
113MAP3K90.63041414
114ALK0.61687021
115YES10.61503442
116ATM0.61137440
117PRKD20.58825932
118PRKCQ0.58080021
119TAOK30.58060950
120TTK0.57823780
121TNK20.57638863
122MELK0.56996261
123FGR0.56963331
124PRKCE0.56685737
125SYK0.55925400
126CDC42BPA0.55374681
127OBSCN0.54077490
128DAPK10.51960180
129MAPK100.51768154
130EIF2AK20.49787686
131RPS6KA30.49480046
132HCK0.47403054
133TIE10.46845696
134DYRK1B0.46717337
135CSNK1D0.46662334
136MAP3K120.46327946
137FYN0.45851744
138LCK0.45405489
139INSRR0.45210637
140CLK10.44993063
141BCKDK0.44169164
142EEF2K0.43245229
143CSNK1A10.43131510
144MAPK90.41899982
145CAMK2A0.41357347
146STK30.41104104
147GSK3B0.40964939
148CHEK20.40757883
149ADRBK10.40177343
150* PRKCB0.39358259
151MAPK120.39249377
152PIM10.34505868
153MARK30.33038697
154EPHA30.32492416
155NEK10.31718949
156MAP3K50.30810974
157CDK80.30238185

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.61045472
2Non-homologous end-joining_Homo sapiens_hsa034503.79736365
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87324078
4Basal transcription factors_Homo sapiens_hsa030222.86316909
5Nicotine addiction_Homo sapiens_hsa050332.63822628
6Fanconi anemia pathway_Homo sapiens_hsa034602.58629255
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58270816
8Protein export_Homo sapiens_hsa030602.58154669
9Olfactory transduction_Homo sapiens_hsa047402.48292909
10RNA degradation_Homo sapiens_hsa030182.41491223
11Homologous recombination_Homo sapiens_hsa034402.35856769
12Morphine addiction_Homo sapiens_hsa050322.23663815
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22326843
14Mismatch repair_Homo sapiens_hsa034302.21309430
15Butanoate metabolism_Homo sapiens_hsa006502.17753055
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17146162
17GABAergic synapse_Homo sapiens_hsa047272.16422093
18Circadian entrainment_Homo sapiens_hsa047132.05627335
19Propanoate metabolism_Homo sapiens_hsa006402.05452123
20Glutamatergic synapse_Homo sapiens_hsa047242.02423321
21RNA polymerase_Homo sapiens_hsa030201.96995710
22Long-term potentiation_Homo sapiens_hsa047201.94245844
23Proteasome_Homo sapiens_hsa030501.81752656
24Dopaminergic synapse_Homo sapiens_hsa047281.73027859
25T cell receptor signaling pathway_Homo sapiens_hsa046601.65991390
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60886300
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60110473
28RNA transport_Homo sapiens_hsa030131.55077457
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54833097
30Cholinergic synapse_Homo sapiens_hsa047251.54241255
31Synaptic vesicle cycle_Homo sapiens_hsa047211.54237937
32Amphetamine addiction_Homo sapiens_hsa050311.51992718
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49168342
34Primary immunodeficiency_Homo sapiens_hsa053401.47692797
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47521124
36Renin secretion_Homo sapiens_hsa049241.46987857
37Insulin secretion_Homo sapiens_hsa049111.46651600
38Oxidative phosphorylation_Homo sapiens_hsa001901.46436212
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46417849
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44182882
41Salivary secretion_Homo sapiens_hsa049701.42980063
42Oxytocin signaling pathway_Homo sapiens_hsa049211.42159193
43Regulation of autophagy_Homo sapiens_hsa041401.40946280
44Nucleotide excision repair_Homo sapiens_hsa034201.40781746
45DNA replication_Homo sapiens_hsa030301.40757778
46Base excision repair_Homo sapiens_hsa034101.40272119
47Steroid biosynthesis_Homo sapiens_hsa001001.40257944
48Dorso-ventral axis formation_Homo sapiens_hsa043201.39656269
49Selenocompound metabolism_Homo sapiens_hsa004501.38694971
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37591917
51Taste transduction_Homo sapiens_hsa047421.34966350
52Serotonergic synapse_Homo sapiens_hsa047261.32410263
53Circadian rhythm_Homo sapiens_hsa047101.27308537
54Spliceosome_Homo sapiens_hsa030401.25637552
55Type II diabetes mellitus_Homo sapiens_hsa049301.23530280
56Gastric acid secretion_Homo sapiens_hsa049711.20714318
57Parkinsons disease_Homo sapiens_hsa050121.17757164
58cAMP signaling pathway_Homo sapiens_hsa040241.16722326
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16436261
60Colorectal cancer_Homo sapiens_hsa052101.15296455
61Axon guidance_Homo sapiens_hsa043601.14776675
62Alcoholism_Homo sapiens_hsa050341.14188538
63Cocaine addiction_Homo sapiens_hsa050301.13865759
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13798259
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11879841
66GnRH signaling pathway_Homo sapiens_hsa049121.11844271
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11513864
68Long-term depression_Homo sapiens_hsa047301.10235973
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08321114
70ErbB signaling pathway_Homo sapiens_hsa040121.08213835
71Nitrogen metabolism_Homo sapiens_hsa009101.07457688
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05202197
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04830240
74Peroxisome_Homo sapiens_hsa041461.03896932
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03185122
76One carbon pool by folate_Homo sapiens_hsa006701.03146866
77Renal cell carcinoma_Homo sapiens_hsa052111.02287837
78Calcium signaling pathway_Homo sapiens_hsa040201.00168647
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99369477
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.97071203
81Cell cycle_Homo sapiens_hsa041100.96317510
82B cell receptor signaling pathway_Homo sapiens_hsa046620.96277730
83Estrogen signaling pathway_Homo sapiens_hsa049150.95192467
84MAPK signaling pathway_Homo sapiens_hsa040100.95037488
85Inositol phosphate metabolism_Homo sapiens_hsa005620.93623463
86Gap junction_Homo sapiens_hsa045400.93237306
87Linoleic acid metabolism_Homo sapiens_hsa005910.93104268
88Non-small cell lung cancer_Homo sapiens_hsa052230.91527103
89Chemokine signaling pathway_Homo sapiens_hsa040620.91510454
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91281919
91mTOR signaling pathway_Homo sapiens_hsa041500.89250715
92Choline metabolism in cancer_Homo sapiens_hsa052310.85418873
93Purine metabolism_Homo sapiens_hsa002300.85291562
94Glioma_Homo sapiens_hsa052140.85240546
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84677235
96Endometrial cancer_Homo sapiens_hsa052130.83762489
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82145683
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80435683
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80394562
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78131922
101p53 signaling pathway_Homo sapiens_hsa041150.77762080
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.76634031
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.76519474
104beta-Alanine metabolism_Homo sapiens_hsa004100.75756224
105Melanogenesis_Homo sapiens_hsa049160.74912479
106Wnt signaling pathway_Homo sapiens_hsa043100.74726429
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73796294
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.73267282
109Huntingtons disease_Homo sapiens_hsa050160.72810751
110Pancreatic cancer_Homo sapiens_hsa052120.72551804
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71147177
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69599250
113Ether lipid metabolism_Homo sapiens_hsa005650.69377941
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67535458
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.67357122
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66704758
117VEGF signaling pathway_Homo sapiens_hsa043700.66292413
118FoxO signaling pathway_Homo sapiens_hsa040680.64621450
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64601545
120Pancreatic secretion_Homo sapiens_hsa049720.62911425
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60865569
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60307140
123Ras signaling pathway_Homo sapiens_hsa040140.59336473
124Osteoclast differentiation_Homo sapiens_hsa043800.58910739
125Systemic lupus erythematosus_Homo sapiens_hsa053220.57823315
126Oocyte meiosis_Homo sapiens_hsa041140.57102057
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56740981
128Prolactin signaling pathway_Homo sapiens_hsa049170.56478546
129Alzheimers disease_Homo sapiens_hsa050100.55710308
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55477168
131mRNA surveillance pathway_Homo sapiens_hsa030150.55170143
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54401497
133Notch signaling pathway_Homo sapiens_hsa043300.54147624
134Pyrimidine metabolism_Homo sapiens_hsa002400.53959648
135Hepatitis B_Homo sapiens_hsa051610.53783591
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53497196
137Lysine degradation_Homo sapiens_hsa003100.53163805
138Platelet activation_Homo sapiens_hsa046110.52798456
139Caffeine metabolism_Homo sapiens_hsa002320.52011560
140Chronic myeloid leukemia_Homo sapiens_hsa052200.51884918
141Rap1 signaling pathway_Homo sapiens_hsa040150.51359397
142Endocytosis_Homo sapiens_hsa041440.51190835
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50936185
144Type I diabetes mellitus_Homo sapiens_hsa049400.50508242
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49726186
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.47895246
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47753749
148Tryptophan metabolism_Homo sapiens_hsa003800.47379543
149Dilated cardiomyopathy_Homo sapiens_hsa054140.47224133
150Acute myeloid leukemia_Homo sapiens_hsa052210.46946901
151Glucagon signaling pathway_Homo sapiens_hsa049220.46193843
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.46091822
153Thyroid hormone synthesis_Homo sapiens_hsa049180.45618132
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44605431
155Collecting duct acid secretion_Homo sapiens_hsa049660.41358395
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41264544
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40081154
158Fatty acid elongation_Homo sapiens_hsa000620.39837514
159Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37273073
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.36438251
161Graft-versus-host disease_Homo sapiens_hsa053320.35922102
162Metabolic pathways_Homo sapiens_hsa011000.33269435
163NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31914627
164Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31820410
165Hedgehog signaling pathway_Homo sapiens_hsa043400.27041274
166RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26199196
167Epstein-Barr virus infection_Homo sapiens_hsa051690.24912577
168Autoimmune thyroid disease_Homo sapiens_hsa053200.24706997

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