SP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.70661578
2very-low-density lipoprotein particle assembly (GO:0034379)7.47899334
3plasma lipoprotein particle assembly (GO:0034377)7.41251817
4negative regulation of fibrinolysis (GO:0051918)6.54217172
5intestinal cholesterol absorption (GO:0030299)6.53838592
6protein-lipid complex assembly (GO:0065005)6.45755304
7low-density lipoprotein particle remodeling (GO:0034374)6.09799931
8peptidyl-glutamic acid carboxylation (GO:0017187)6.04242038
9protein carboxylation (GO:0018214)6.04242038
10proline metabolic process (GO:0006560)5.92448050
11transcription from mitochondrial promoter (GO:0006390)5.78982599
12embryonic process involved in female pregnancy (GO:0060136)5.71601542
13protein-lipid complex remodeling (GO:0034368)5.65259116
14macromolecular complex remodeling (GO:0034367)5.65259116
15plasma lipoprotein particle remodeling (GO:0034369)5.65259116
16cholesterol efflux (GO:0033344)5.63892662
17regulation of cholesterol esterification (GO:0010872)5.61312611
18regulation of fibrinolysis (GO:0051917)5.46384954
19plasma lipoprotein particle organization (GO:0071827)5.40455533
20establishment of apical/basal cell polarity (GO:0035089)5.29796162
21cell migration involved in gastrulation (GO:0042074)5.20268625
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.19466286
23regulation of gene silencing by RNA (GO:0060966)5.18569709
24regulation of posttranscriptional gene silencing (GO:0060147)5.18569709
25regulation of gene silencing by miRNA (GO:0060964)5.18569709
26regulation of bile acid biosynthetic process (GO:0070857)5.04261004
27protein-lipid complex subunit organization (GO:0071825)5.00535998
28high-density lipoprotein particle remodeling (GO:0034375)4.95231490
29regulation of apoptotic cell clearance (GO:2000425)4.94530649
30plasma lipoprotein particle clearance (GO:0034381)4.89992737
31regulation of cholesterol homeostasis (GO:2000188)4.79846779
32anterior/posterior axis specification, embryo (GO:0008595)4.78601926
33DNA deamination (GO:0045006)4.76311752
34lung epithelium development (GO:0060428)4.75796583
35reverse cholesterol transport (GO:0043691)4.74504456
36nodal signaling pathway (GO:0038092)4.74099055
37replication fork processing (GO:0031297)4.70014376
38establishment of monopolar cell polarity (GO:0061162)4.48656164
39establishment or maintenance of monopolar cell polarity (GO:0061339)4.48656164
40mitochondrial DNA metabolic process (GO:0032042)4.41324198
41intestinal absorption (GO:0050892)4.41091642
42negative regulation of cholesterol transport (GO:0032375)4.39056019
43negative regulation of sterol transport (GO:0032372)4.39056019
44regulation of cholesterol biosynthetic process (GO:0045540)4.37943210
45regulation of plasminogen activation (GO:0010755)4.36879741
46primitive streak formation (GO:0090009)4.34364466
47trophectodermal cell differentiation (GO:0001829)4.29225706
48blood coagulation, intrinsic pathway (GO:0007597)4.27683519
49regulation of protein activation cascade (GO:2000257)4.27635608
50regulation of complement activation (GO:0030449)4.20070413
51formation of translation preinitiation complex (GO:0001731)4.16580264
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.16056159
53L-phenylalanine catabolic process (GO:0006559)4.11472183
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.11472183
55somatic hypermutation of immunoglobulin genes (GO:0016446)4.10565017
56somatic diversification of immune receptors via somatic mutation (GO:0002566)4.10565017
57L-phenylalanine metabolic process (GO:0006558)4.08572702
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.08572702
59positive regulation of protein homooligomerization (GO:0032464)4.07636900
60regulation of hippo signaling (GO:0035330)4.02112246
61secondary heart field specification (GO:0003139)3.97197049
62heart field specification (GO:0003128)3.97197049
63regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.88422799
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.86166997
65negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.84316706
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83642020
67regulation of sister chromatid cohesion (GO:0007063)3.78084115
68somite rostral/caudal axis specification (GO:0032525)3.77195485
69paraxial mesoderm development (GO:0048339)3.74364537
70mitotic G1 DNA damage checkpoint (GO:0031571)3.73571361
71histone H4-K12 acetylation (GO:0043983)3.73442061
72regulation of non-canonical Wnt signaling pathway (GO:2000050)3.69897410
73regulation of translational fidelity (GO:0006450)3.69677011
74regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.69586127
75signal transduction involved in regulation of gene expression (GO:0023019)3.68820710
76positive regulation of fatty acid biosynthetic process (GO:0045723)3.67551273
77diacylglycerol metabolic process (GO:0046339)3.63730125
78regulation of integrin activation (GO:0033623)3.63371669
79phospholipid efflux (GO:0033700)3.63159439
80phosphate ion homeostasis (GO:0055062)3.61367105
81trivalent inorganic anion homeostasis (GO:0072506)3.61367105
82viral mRNA export from host cell nucleus (GO:0046784)3.60529436
83glutamate metabolic process (GO:0006536)3.60199030
84regulation of protein homooligomerization (GO:0032462)3.59791248
85pre-miRNA processing (GO:0031054)3.59168530
86negative regulation of cell cycle arrest (GO:0071157)3.57820704
87low-density lipoprotein particle clearance (GO:0034383)3.54670193
88oligosaccharide catabolic process (GO:0009313)3.53691312
89mitotic sister chromatid segregation (GO:0000070)3.52708386
90cholesterol homeostasis (GO:0042632)3.48825858
91sterol homeostasis (GO:0055092)3.46832274
92lipoprotein metabolic process (GO:0042157)3.46122018
93cellular zinc ion homeostasis (GO:0006882)3.43299436
94negative regulation of mRNA processing (GO:0050686)3.41510077
95cholesterol transport (GO:0030301)3.38486309
96sterol transport (GO:0015918)3.38486309
97positive regulation of hormone biosynthetic process (GO:0046886)3.36882703
98heterochromatin organization (GO:0070828)3.31579730
99oxidative demethylation (GO:0070989)3.31116799
100convergent extension (GO:0060026)3.30984912
101DNA integration (GO:0015074)3.29745808
102positive regulation of hormone metabolic process (GO:0032352)3.28225936
103G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26409142
104positive regulation of dendritic spine morphogenesis (GO:0061003)3.26035339
105embryonic placenta development (GO:0001892)3.25152211
106glutamine family amino acid biosynthetic process (GO:0009084)3.24436839
107spliceosomal tri-snRNP complex assembly (GO:0000244)3.24344596
108positive regulation of triglyceride lipase activity (GO:0061365)3.23596835
109positive regulation of lipoprotein lipase activity (GO:0051006)3.23596835
110mitotic G1/S transition checkpoint (GO:0044819)3.21732661
111embryonic camera-type eye development (GO:0031076)3.20008076
112positive regulation of steroid metabolic process (GO:0045940)3.19156000
113embryonic retina morphogenesis in camera-type eye (GO:0060059)3.18018835
114apoptotic process involved in morphogenesis (GO:0060561)3.17079607
115pinocytosis (GO:0006907)3.16889942
116SMAD protein signal transduction (GO:0060395)3.16630378
117DNA strand renaturation (GO:0000733)3.14778929
118telomere maintenance via semi-conservative replication (GO:0032201)3.13967677
119G1 DNA damage checkpoint (GO:0044783)3.13048327
120regulation of double-strand break repair via homologous recombination (GO:0010569)3.11372192
121mitochondrial DNA replication (GO:0006264)3.10446127
122regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.09306664
123negative regulation of androgen receptor signaling pathway (GO:0060766)3.09197132
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09067491
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09067491
126positive regulation of mitotic sister chromatid separation (GO:1901970)3.09067491
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.08731466
128vitamin transmembrane transport (GO:0035461)3.06302336
129negative regulation of RNA splicing (GO:0033119)3.05854301
130intestinal epithelial cell development (GO:0060576)3.05572939
131histone arginine methylation (GO:0034969)3.05041856
132mitochondrial RNA metabolic process (GO:0000959)3.05033313
133regulation of mesoderm development (GO:2000380)3.02877414
134positive regulation by host of viral transcription (GO:0043923)3.02530085
135morphogenesis of embryonic epithelium (GO:0016331)3.00959008
1364-hydroxyproline metabolic process (GO:0019471)2.99373809
137DNA strand elongation involved in DNA replication (GO:0006271)2.98505290
138polarized epithelial cell differentiation (GO:0030859)2.98423476
139base-excision repair (GO:0006284)2.98090354
140renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.97801822
141modified amino acid transport (GO:0072337)2.97686358
142regulation of double-strand break repair (GO:2000779)2.96497686
143morphogenesis of an epithelial fold (GO:0060571)2.94978809
144negative regulation of Ras GTPase activity (GO:0034261)2.93106486
145acylglycerol homeostasis (GO:0055090)2.92929148
146triglyceride homeostasis (GO:0070328)2.92929148
147termination of RNA polymerase II transcription (GO:0006369)2.92678667
148protein localization to kinetochore (GO:0034501)2.90913057
149DNA unwinding involved in DNA replication (GO:0006268)2.90663316
150negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90523144
151regulation of DNA damage checkpoint (GO:2000001)2.89722565
152acute-phase response (GO:0006953)2.89499264
153ribosome biogenesis (GO:0042254)2.89390123
154positive regulation of male gonad development (GO:2000020)2.88433501
155regulation of cholesterol metabolic process (GO:0090181)2.88344906
156anterior/posterior axis specification (GO:0009948)2.88242142
157notochord development (GO:0030903)2.87152465
158intracellular estrogen receptor signaling pathway (GO:0030520)2.86463454
159receptor catabolic process (GO:0032801)2.85934248
160sister chromatid segregation (GO:0000819)2.85718298
161negative regulation of sodium ion transport (GO:0010766)2.84002419
162negative regulation of JAK-STAT cascade (GO:0046426)2.83812972
163meiotic chromosome segregation (GO:0045132)2.83196735
164mRNA cleavage (GO:0006379)2.83064149
165mesenchymal cell proliferation (GO:0010463)2.82891478
166nephron tubule morphogenesis (GO:0072078)2.82050909
167nephron epithelium morphogenesis (GO:0072088)2.82050909
168lipid homeostasis (GO:0055088)2.80914244
169regulation of extracellular matrix organization (GO:1903053)2.79882885
170sulfur amino acid catabolic process (GO:0000098)2.79476761
171negative regulation of mRNA metabolic process (GO:1903312)2.79387981
172DNA strand elongation (GO:0022616)2.78569206
173positive regulation of extracellular matrix organization (GO:1903055)2.78140378
174fatty acid homeostasis (GO:0055089)2.77995822
175positive regulation of SMAD protein import into nucleus (GO:0060391)2.76618837
176positive regulation of developmental pigmentation (GO:0048087)2.75668770
177regulation of RNA export from nucleus (GO:0046831)2.75070830
178pseudouridine synthesis (GO:0001522)2.74928956
179positive regulation of chromosome segregation (GO:0051984)2.74168712
180peptidyl-arginine omega-N-methylation (GO:0035247)2.73854131
181negative regulation of norepinephrine secretion (GO:0010700)2.73671610
182branching involved in mammary gland duct morphogenesis (GO:0060444)2.73409028
183folic acid-containing compound biosynthetic process (GO:0009396)2.72900888
184peptidyl-glutamic acid modification (GO:0018200)2.72094814
185regulation of norepinephrine secretion (GO:0014061)2.71031909
186fibrinolysis (GO:0042730)2.65452053
187drinking behavior (GO:0042756)2.64496369
188mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.64129877
189positive regulation of hemostasis (GO:1900048)2.63108643
190positive regulation of blood coagulation (GO:0030194)2.63108643
191regulation of extracellular matrix disassembly (GO:0010715)2.60249576
192neurotransmitter-gated ion channel clustering (GO:0072578)2.58442199
193serine family amino acid biosynthetic process (GO:0009070)2.58320483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.18029114
2E2F7_22180533_ChIP-Seq_HELA_Human4.13555733
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.93119561
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.93119561
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.93119561
6ZNF263_19887448_ChIP-Seq_K562_Human3.56027504
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.46110040
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36415039
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.20238554
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.01944310
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95685877
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.86883571
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73705641
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72774486
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70057444
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.67284139
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63967344
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.62482242
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.60677654
20* FOXA2_19822575_ChIP-Seq_HepG2_Human2.59612627
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59248701
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.54015260
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.52125471
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46899131
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46634174
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43549127
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.42439207
28* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.40662580
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.22743483
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21568955
31LXR_22158963_ChIP-Seq_LIVER_Mouse2.20544656
32* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.18433094
33MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16241002
34* HNF4A_19822575_ChIP-Seq_HepG2_Human2.15398399
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10495398
36POU5F1_16518401_ChIP-PET_MESCs_Mouse2.06704379
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05372228
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.03999874
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97792683
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97614209
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92811440
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91689773
43CLOCK_20551151_ChIP-Seq_293T_Human1.87117556
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.82822122
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80831468
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74792195
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74714470
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.73573371
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69544248
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.68920528
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67311120
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67186130
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62373745
54OCT4_18692474_ChIP-Seq_MEFs_Mouse1.59903206
55* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59700288
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58157952
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.56165370
58SOX2_18692474_ChIP-Seq_MEFs_Mouse1.55261609
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55187091
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.54807269
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52862877
62XRN2_22483619_ChIP-Seq_HELA_Human1.51148067
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50363502
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49330634
65POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.48258404
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47296621
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46766395
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45465401
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43414646
70SOX2_18692474_ChIP-Seq_MESCs_Mouse1.41977220
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.41141336
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41080122
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39415367
74TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37030162
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.36088942
76NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35297066
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34787054
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.34295620
79MYC_22102868_ChIP-Seq_BL_Human1.33297555
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.32317104
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28974782
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28479412
83* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28087591
84LXR_22292898_ChIP-Seq_THP-1_Human1.27975785
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27537742
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.27523315
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27253636
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27043525
89RACK7_27058665_Chip-Seq_MCF-7_Human1.25810395
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.25401082
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25129300
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23858153
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22999165
94TTF2_22483619_ChIP-Seq_HELA_Human1.20791559
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20514570
96VDR_21846776_ChIP-Seq_THP-1_Human1.19097341
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19077620
98* SOX17_20123909_ChIP-Seq_XEN_Mouse1.18249672
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17217972
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.16421509
101PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15948283
102DCP1A_22483619_ChIP-Seq_HELA_Human1.12219991
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11050265
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09996875
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08961565
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07984380
107AR_21909140_ChIP-Seq_LNCAP_Human1.06789456
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06169227
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05893497
110GABP_19822575_ChIP-Seq_HepG2_Human1.05702986
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04948621
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04903598
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03607836
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03075369
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01504469
116CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01200482
117KDM5A_27292631_Chip-Seq_BREAST_Human1.00801828
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.00345512
119* E2F1_21310950_ChIP-Seq_MCF-7_Human0.98374785
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98363187
121* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98321784
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.98297076
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98202448
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.97894700
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96918794
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96525846
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96263341
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95933492
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92949148
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92836136
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.91278587
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91107096
133KAP1_27257070_Chip-Seq_ESCs_Mouse0.90659377
134GATA6_25053715_ChIP-Seq_YYC3_Human0.90263501
135* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88266116
136ATF3_27146783_Chip-Seq_COLON_Human0.87901797
137* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87423874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.50569509
2MP0000566_synostosis4.98283900
3MP0008057_abnormal_DNA_replication4.41158290
4MP0010030_abnormal_orbit_morphology4.36650754
5MP0003890_abnormal_embryonic-extraembry4.19890176
6MP0002139_abnormal_hepatobiliary_system3.67707096
7MP0003195_calcinosis3.27878605
8MP0004133_heterotaxia3.22625367
9MP0004957_abnormal_blastocyst_morpholog3.12271129
10MP0002653_abnormal_ependyma_morphology3.04299395
11MP0005365_abnormal_bile_salt2.98133720
12MP0003119_abnormal_digestive_system2.81891074
13MP0010329_abnormal_lipoprotein_level2.76437910
14MP0002089_abnormal_postnatal_growth/wei2.72849664
15MP0001666_abnormal_nutrient_absorption2.70180009
16MP0004264_abnormal_extraembryonic_tissu2.63344444
17MP0003283_abnormal_digestive_organ2.62987774
18MP0003172_abnormal_lysosome_physiology2.38094592
19MP0010352_gastrointestinal_tract_polyps2.29274854
20MP0003121_genomic_imprinting2.28704601
21MP0010094_abnormal_chromosome_stability2.28284593
22MP0002938_white_spotting2.26251788
23MP0003693_abnormal_embryo_hatching2.07123385
24MP0003111_abnormal_nucleus_morphology2.03607860
25MP0002084_abnormal_developmental_patter2.02603964
26MP0002254_reproductive_system_inflammat1.99692967
27MP0002085_abnormal_embryonic_tissue1.91227918
28MP0003077_abnormal_cell_cycle1.91130858
29MP0008932_abnormal_embryonic_tissue1.88162822
30MP0000462_abnormal_digestive_system1.87829258
31MP0001672_abnormal_embryogenesis/_devel1.87236320
32MP0005380_embryogenesis_phenotype1.87236320
33MP0005408_hypopigmentation1.85970337
34MP0009278_abnormal_bone_marrow1.84838969
35MP0001730_embryonic_growth_arrest1.84048949
36MP0001293_anophthalmia1.82605128
37MP0008875_abnormal_xenobiotic_pharmacok1.79382471
38MP0002086_abnormal_extraembryonic_tissu1.78579757
39MP0001697_abnormal_embryo_size1.78244232
40MP0005257_abnormal_intraocular_pressure1.70826772
41MP0003123_paternal_imprinting1.69883996
42MP0003136_yellow_coat_color1.67904446
43MP0004233_abnormal_muscle_weight1.66249497
44MP0004197_abnormal_fetal_growth/weight/1.65177004
45MP0001915_intracranial_hemorrhage1.63427247
46MP0005451_abnormal_body_composition1.62158729
47MP0000678_abnormal_parathyroid_gland1.61299011
48MP0002009_preneoplasia1.56535072
49* MP0002111_abnormal_tail_morphology1.54896117
50MP0006072_abnormal_retinal_apoptosis1.54428982
51MP0002249_abnormal_larynx_morphology1.53282647
52MP0003984_embryonic_growth_retardation1.50124121
53MP0000762_abnormal_tongue_morphology1.49603925
54MP0000537_abnormal_urethra_morphology1.49473842
55MP0002088_abnormal_embryonic_growth/wei1.48324520
56MP0000350_abnormal_cell_proliferation1.46682906
57MP0002932_abnormal_joint_morphology1.45323182
58MP0000490_abnormal_crypts_of1.43875998
59MP0004272_abnormal_basement_membrane1.43001175
60MP0005171_absent_coat_pigmentation1.38658915
61MP0002796_impaired_skin_barrier1.37630078
62MP0003806_abnormal_nucleotide_metabolis1.35367908
63MP0009053_abnormal_anal_canal1.34686243
64MP0006054_spinal_hemorrhage1.32792173
65MP0003786_premature_aging1.32463442
66MP0000049_abnormal_middle_ear1.31863828
67MP0002233_abnormal_nose_morphology1.30134301
68MP0005076_abnormal_cell_differentiation1.29403327
69MP0008058_abnormal_DNA_repair1.29305734
70MP0000432_abnormal_head_morphology1.28206188
71MP0006292_abnormal_olfactory_placode1.27865177
72MP0003878_abnormal_ear_physiology1.25710150
73MP0005377_hearing/vestibular/ear_phenot1.25710150
74MP0003935_abnormal_craniofacial_develop1.25690613
75MP0005085_abnormal_gallbladder_physiolo1.25177412
76MP0002080_prenatal_lethality1.22733005
77MP0003115_abnormal_respiratory_system1.21362186
78MP0009672_abnormal_birth_weight1.20661713
79MP0003705_abnormal_hypodermis_morpholog1.19520685
80MP0003941_abnormal_skin_development1.18375378
81MP0003453_abnormal_keratinocyte_physiol1.12739769
82MP0001849_ear_inflammation1.12368842
83MP0005266_abnormal_metabolism1.11554463
84MP0005332_abnormal_amino_acid1.10132612
85MP0008995_early_reproductive_senescence1.09928716
86MP0005058_abnormal_lysosome_morphology1.09874863
87MP0002332_abnormal_exercise_endurance1.07180933
88MP0003755_abnormal_palate_morphology1.07002207
89MP0002132_abnormal_respiratory_system1.06027549
90MP0005501_abnormal_skin_physiology1.05645211
91MP0000609_abnormal_liver_physiology1.04654599
92MP0002116_abnormal_craniofacial_bone1.01963344
93MP0003315_abnormal_perineum_morphology1.01710827
94MP0009384_cardiac_valve_regurgitation1.00735790
95MP0002092_abnormal_eye_morphology1.00340451
96MP0005360_urolithiasis1.00135614
97MP0003566_abnormal_cell_adhesion0.98105203
98MP0002118_abnormal_lipid_homeostasis0.97844958
99MP0000639_abnormal_adrenal_gland0.96597300
100MP0003252_abnormal_bile_duct0.95869767
101MP0001661_extended_life_span0.95422076
102MP0000428_abnormal_craniofacial_morphol0.93638352
103MP0001286_abnormal_eye_development0.93442256
104MP0002098_abnormal_vibrissa_morphology0.92429110
105MP0005248_abnormal_Harderian_gland0.91411052
106MP0003937_abnormal_limbs/digits/tail_de0.91073068
107MP0008007_abnormal_cellular_replicative0.90030867
108MP0009780_abnormal_chondrocyte_physiolo0.89725361
109MP0000579_abnormal_nail_morphology0.89680940
110MP0003942_abnormal_urinary_system0.89514876
111* MP0002114_abnormal_axial_skeleton0.88957980
112MP0002160_abnormal_reproductive_system0.88729329
113MP0004858_abnormal_nervous_system0.88339106
114MP0000470_abnormal_stomach_morphology0.87178907
115MP0000313_abnormal_cell_death0.85574674
116MP0003385_abnormal_body_wall0.85476680
117MP0002282_abnormal_trachea_morphology0.84565803
118MP0003861_abnormal_nervous_system0.84435858
119MP0001340_abnormal_eyelid_morphology0.84417049
120MP0000477_abnormal_intestine_morphology0.83992785
121MP0002697_abnormal_eye_size0.83384018
122MP0004019_abnormal_vitamin_homeostasis0.82619218
123MP0003567_abnormal_fetal_cardiomyocyte0.82506947
124MP0001346_abnormal_lacrimal_gland0.82091077
125MP0008877_abnormal_DNA_methylation0.81987858
126MP0003718_maternal_effect0.81599701
127MP0005394_taste/olfaction_phenotype0.80475296
128MP0005499_abnormal_olfactory_system0.80475296
129MP0010234_abnormal_vibrissa_follicle0.80313137
130MP0003938_abnormal_ear_development0.80186088
131MP0000534_abnormal_ureter_morphology0.80072164
132MP0005075_abnormal_melanosome_morpholog0.78981371
133MP0000598_abnormal_liver_morphology0.77358391
134MP0003936_abnormal_reproductive_system0.75953968
135MP0003868_abnormal_feces_composition0.75921599
136MP0002925_abnormal_cardiovascular_devel0.74597068
137MP0001324_abnormal_eye_pigmentation0.74204131
138MP0003943_abnormal_hepatobiliary_system0.73629374
139MP0005220_abnormal_exocrine_pancreas0.72870008
140MP0009379_abnormal_foot_pigmentation0.72003468
141MP0005084_abnormal_gallbladder_morpholo0.71812994
142MP0002127_abnormal_cardiovascular_syste0.71582602
143MP0005391_vision/eye_phenotype0.70830875
144MP0002019_abnormal_tumor_incidence0.69606642
145MP0008260_abnormal_autophagy0.68108589
146MP0009697_abnormal_copulation0.67636732
147MP0009840_abnormal_foam_cell0.67359696
148MP0005379_endocrine/exocrine_gland_phen0.67065425
149MP0001529_abnormal_vocalization0.66515922
150MP0004185_abnormal_adipocyte_glucose0.65170987
151MP0005409_darkened_coat_color0.64800256
152MP0005167_abnormal_blood-brain_barrier0.64116830

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.01364551
2Rib fusion (HP:0000902)6.43228137
3Prolonged partial thromboplastin time (HP:0003645)5.91872791
4Joint hemorrhage (HP:0005261)5.30538401
5Hypobetalipoproteinemia (HP:0003563)5.08241538
6Aplasia/hypoplasia of the humerus (HP:0006507)4.50476390
7Short humerus (HP:0005792)4.47907670
8Rectal fistula (HP:0100590)4.40155903
9Rectovaginal fistula (HP:0000143)4.40155903
10Hypercholesterolemia (HP:0003124)4.30219312
11Vaginal fistula (HP:0004320)4.03195262
12Hemorrhage of the eye (HP:0011885)3.91689521
13Intestinal fistula (HP:0100819)3.89122334
14Small epiphyses (HP:0010585)3.86620175
15Absent radius (HP:0003974)3.81821018
16Xanthomatosis (HP:0000991)3.80184318
17Absent forearm bone (HP:0003953)3.66706897
18Aplasia involving forearm bones (HP:0009822)3.66706897
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65742207
20Concave nail (HP:0001598)3.63067417
21Abnormal hemoglobin (HP:0011902)3.47279232
22Facial hemangioma (HP:0000329)3.40560480
23Abnormality of the common coagulation pathway (HP:0010990)3.39460663
24Abnormality of abdominal situs (HP:0011620)3.37296692
25Abdominal situs inversus (HP:0003363)3.37296692
26Ulnar bowing (HP:0003031)3.34050031
27Irregular epiphyses (HP:0010582)3.33069306
28Hypochromic microcytic anemia (HP:0004840)3.29694870
29Complement deficiency (HP:0004431)3.29008899
30Hepatoblastoma (HP:0002884)3.22081650
31Hypolipoproteinemia (HP:0010981)3.19419522
32Annular pancreas (HP:0001734)3.12013260
33Asymmetry of the thorax (HP:0001555)3.11769040
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10244833
35Turricephaly (HP:0000262)3.04562775
36Vertebral fusion (HP:0002948)3.03915224
37Selective tooth agenesis (HP:0001592)3.02448355
38Hypoplasia of the capital femoral epiphysis (HP:0003090)2.97517008
39Ependymoma (HP:0002888)2.97172777
40Acanthocytosis (HP:0001927)2.95776162
41Broad palm (HP:0001169)2.95330333
42Abnormality of carpal bone ossification (HP:0006257)2.94123932
43Alacrima (HP:0000522)2.92755417
44Tongue fasciculations (HP:0001308)2.91268280
45Absent thumb (HP:0009777)2.90245992
46Vertebral hypoplasia (HP:0008417)2.87139669
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.87139669
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.79048946
49Absent epiphyses (HP:0010577)2.79048946
50Glomerulonephritis (HP:0000099)2.78991984
51Epiphyseal dysplasia (HP:0002656)2.75865258
52Menorrhagia (HP:0000132)2.71886338
53Missing ribs (HP:0000921)2.70571154
54Shawl scrotum (HP:0000049)2.67842764
55Muscle fibrillation (HP:0010546)2.67792882
56Abnormal tarsal ossification (HP:0008369)2.63522806
57Intestinal atresia (HP:0011100)2.63029001
58Hemivertebrae (HP:0002937)2.61667122
59Pustule (HP:0200039)2.61143579
60Abnormality of the lumbar spine (HP:0100712)2.59984238
61Trismus (HP:0000211)2.59319145
62Abnormality of the labia minora (HP:0012880)2.59131945
63Hypophosphatemic rickets (HP:0004912)2.57620698
64Hyperglycinemia (HP:0002154)2.57214094
65Abnormality of the astrocytes (HP:0100707)2.57101780
66Astrocytoma (HP:0009592)2.57101780
67Coronal craniosynostosis (HP:0004440)2.54351125
68Hypoglycemic coma (HP:0001325)2.52925305
69Poikiloderma (HP:0001029)2.49679457
70Epidermoid cyst (HP:0200040)2.46856426
71Bilateral microphthalmos (HP:0007633)2.45103884
72Diastasis recti (HP:0001540)2.44685396
73Abnormality of the lacrimal duct (HP:0011481)2.42719091
74Abnormality of complement system (HP:0005339)2.41437843
75Abnormality of the aortic arch (HP:0012303)2.40985060
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39296192
77Abnormality of the nasal septum (HP:0000419)2.38559049
78Fused cervical vertebrae (HP:0002949)2.37612030
79Orthostatic hypotension (HP:0001278)2.36810864
80Spontaneous abortion (HP:0005268)2.36195291
81Abnormality of the lower motor neuron (HP:0002366)2.35485848
82Flat acetabular roof (HP:0003180)2.35067959
83Short 5th finger (HP:0009237)2.32753203
84Patellar aplasia (HP:0006443)2.32263878
85Abnormal ossification of hand bones (HP:0005921)2.30398306
86Abnormal number of incisors (HP:0011064)2.27782224
87Broad alveolar ridges (HP:0000187)2.27731464
88Squamous cell carcinoma (HP:0002860)2.26754424
89Alopecia of scalp (HP:0002293)2.25698250
90Increased serum pyruvate (HP:0003542)2.24658489
91Embryonal renal neoplasm (HP:0011794)2.24341724
92Abnormality of the ileum (HP:0001549)2.23553734
93Bifid scrotum (HP:0000048)2.23507096
94Neonatal short-limb short stature (HP:0008921)2.23458645
95Hypoplasia of the radius (HP:0002984)2.22782124
96Abnormal hand bone ossification (HP:0010660)2.21417346
97Male infertility (HP:0003251)2.21210994
98Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.20523680
99Hyperglycinuria (HP:0003108)2.18550459
100Abnormality of glycolysis (HP:0004366)2.17295302
101Pseudobulbar signs (HP:0002200)2.17084057
102Increased IgM level (HP:0003496)2.15982351
103Multiple enchondromatosis (HP:0005701)2.15551611
104Abnormality of the alveolar ridges (HP:0006477)2.15423277
105Hypoalphalipoproteinemia (HP:0003233)2.15022712
106Hypotrichosis (HP:0001006)2.14268447
107Basal cell carcinoma (HP:0002671)2.13844523
108Malnutrition (HP:0004395)2.13635899
109Neoplasm of the oral cavity (HP:0100649)2.12848971
110Nasolacrimal duct obstruction (HP:0000579)2.12052353
111Supernumerary spleens (HP:0009799)2.11705263
112Pancreatic islet-cell hyperplasia (HP:0004510)2.11574079
113Aplasia/Hypoplasia of the patella (HP:0006498)2.11305223
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11196380
115Vascular calcification (HP:0004934)2.10814462
116Bronchomalacia (HP:0002780)2.10400785
117Bowing of the arm (HP:0006488)2.10176005
118Bowed forearm bones (HP:0003956)2.10176005
119Decreased lacrimation (HP:0000633)2.09730359
120Limited elbow extension (HP:0001377)2.08548474
121Neoplasm of striated muscle (HP:0009728)2.08426209
122Colon cancer (HP:0003003)2.08341231
123Rhabdomyosarcoma (HP:0002859)2.07460894
124Abnormality of pain sensation (HP:0010832)2.05228586
125Impaired pain sensation (HP:0007328)2.05228586
126Enlarged kidneys (HP:0000105)2.03863654
127Broad thumb (HP:0011304)2.03735340
128Osteomalacia (HP:0002749)2.03203112
129Preaxial foot polydactyly (HP:0001841)2.02321541
130Duplication of thumb phalanx (HP:0009942)2.00946397
131Abnormality of glycine metabolism (HP:0010895)1.99526702
132Abnormality of serine family amino acid metabolism (HP:0010894)1.99526702
133Anal stenosis (HP:0002025)1.99079242
134Preauricular skin tag (HP:0000384)1.98830960
135Gastrointestinal atresia (HP:0002589)1.98661067
136Neonatal death (HP:0003811)1.98203814
137Choanal stenosis (HP:0000452)1.98006593
138Systemic lupus erythematosus (HP:0002725)1.97428111
139Abnormality of the nasolacrimal system (HP:0000614)1.96731371
140Gonadal dysgenesis (HP:0000133)1.96362925
141Abnormality of the vitreous humor (HP:0004327)1.94092371
142Congenital hip dislocation (HP:0001374)1.93236501
143Myelomeningocele (HP:0002475)1.93184374
144Hepatocellular carcinoma (HP:0001402)1.92553295
145Glioma (HP:0009733)1.90103206
146Vertebral clefting (HP:0008428)1.89913464
147Broad toe (HP:0001837)1.89830383
148Volvulus (HP:0002580)1.88483104
149Transposition of the great arteries (HP:0001669)1.87153698
150Abnormal connection of the cardiac segments (HP:0011545)1.87153698
151Abnormal ventriculo-arterial connection (HP:0011563)1.87153698
152Reticulocytopenia (HP:0001896)1.87149192
153Medulloblastoma (HP:0002885)1.86713071
154Skin tags (HP:0010609)1.86588052
155Purpura (HP:0000979)1.86465094
156Intrahepatic cholestasis (HP:0001406)1.86093952
157Carpal synostosis (HP:0009702)1.86060555
158Breast hypoplasia (HP:0003187)1.85416247
159Renal duplication (HP:0000075)1.84741206
160Protrusio acetabuli (HP:0003179)1.84470802
161Abnormality of the humerus (HP:0003063)1.84053714
162Wide nose (HP:0000445)1.83752019
163Hypotelorism (HP:0000601)1.83686834
164Embryonal neoplasm (HP:0002898)1.83208669
165Abnormality of endocrine pancreas physiology (HP:0012093)1.82452366
166Abnormality of the pancreatic islet cells (HP:0006476)1.82452366
167Trigonocephaly (HP:0000243)1.80802992
168Abnormality of the salivary glands (HP:0010286)1.79504862
169Partial duplication of the phalanx of hand (HP:0009999)1.79323828
170Neoplasm of the liver (HP:0002896)1.78851836
171Esophageal atresia (HP:0002032)1.78669563
172Supernumerary ribs (HP:0005815)1.78542300
173Midline defect of the nose (HP:0004122)1.78475833
174Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76617729
175Vitreoretinal degeneration (HP:0000655)1.76380218
176Abnormality of the upper arm (HP:0001454)1.76068283
177Short thumb (HP:0009778)1.74683970
178Anal atresia (HP:0002023)1.74087776
179Premature graying of hair (HP:0002216)1.73519747
180Meckel diverticulum (HP:0002245)1.73111114
181Flared iliac wings (HP:0002869)1.72748088
182Recurrent corneal erosions (HP:0000495)1.72304462
183Spinal muscular atrophy (HP:0007269)1.72159892
184Nephroblastoma (Wilms tumor) (HP:0002667)1.71566621
185Partial duplication of thumb phalanx (HP:0009944)1.71235551
186Premature ovarian failure (HP:0008209)1.69888239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR47.18839498
2ICK4.48185539
3CDK124.26955070
4DDR24.09331448
5FGFR33.59550868
6MAPK153.32889329
7LATS23.27118792
8WNK43.17177736
9EPHA23.00187941
10TYRO32.85457424
11FGFR22.84846425
12MAP3K112.72984505
13SMG12.53968310
14MAP3K62.45325008
15MATK2.36938561
16CDK72.30285831
17BMX2.10968318
18MAP3K101.89090633
19STK38L1.86739916
20VRK21.76958641
21EEF2K1.74367252
22FGR1.73920156
23AKT31.73641828
24TRIB31.68607568
25PDGFRA1.65356176
26TTK1.63026825
27DAPK11.59986508
28PKN21.59555924
29BUB11.57889743
30SCYL21.56699848
31SRPK11.56691833
32RPS6KB21.48134164
33PLK11.47016377
34CDK61.45389569
35TAF11.42921036
36EPHA41.42157496
37CSK1.37605415
38UHMK11.35978426
39PINK11.35657529
40DYRK1B1.35627701
41NME11.35453641
42GRK61.33529043
43CHEK21.32094672
44CDC71.31103536
45PRKD21.30861201
46PASK1.28564145
47STK101.25725428
48NEK21.25662159
49PAK41.24624201
50YES11.23408383
51WNK11.22126298
52PLK31.15135793
53WEE11.10371694
54TESK21.09127617
55PIM21.06719509
56TRPM71.00736935
57BRSK10.98819052
58PIM10.97866916
59STK160.97009424
60LATS10.96379942
61EIF2AK10.95313528
62IRAK30.94636864
63ERN10.93403604
64MTOR0.92819841
65PLK40.91819665
66TSSK60.90716709
67DYRK30.89319667
68ALK0.87148111
69NEK10.83746541
70AURKB0.82815847
71PRKAA20.78915430
72SIK10.78689748
73AURKA0.78429943
74CDK40.77535661
75RET0.76781890
76MAP2K20.76558847
77GSK3A0.76156958
78CHEK10.75644011
79MAP3K80.75157161
80RPS6KL10.73444429
81RPS6KC10.73444429
82PIK3CA0.73085994
83CDK80.72832651
84MAPK110.71979799
85BRSK20.69002573
86AKT20.68185732
87STK380.67727226
88CDK20.67469066
89ATR0.67253764
90PTK20.65215764
91CDC42BPA0.65123105
92PTK60.64912463
93BCKDK0.64164535
94ZAK0.58837384
95PRKCI0.58400211
96RIPK10.55641976
97RPS6KA60.55521703
98TLK10.55372050
99PBK0.55189886
100FLT30.54755434
101SIK20.53336858
102CAMK1D0.52431107
103RPS6KA10.50537408
104DYRK20.50514470
105MET0.49575405
106CSNK1E0.48065679
107SGK2230.47842229
108SGK4940.47842229
109ATM0.47174046
110MELK0.46871282
111PAK10.46438712
112TAOK20.45320884
113MKNK10.44608374
114RPS6KB10.43698615
115STK390.42655958
116CSNK2A10.42553353
117PDPK10.42343002
118NTRK20.42329598
119BCR0.41971129
120PRKG20.41646805
121CDK150.41643885
122ERBB20.41330174
123CDK11A0.40608273
124CSNK2A20.40217981
125SGK10.40031611
126MAP3K90.39783062
127FGFR10.37608098
128CDK180.36687140
129BRD40.35222492
130VRK10.34945290
131CDK10.34742557
132STK40.34396812
133MAPK10.33308537
134NME20.32117811
135GRK50.31485921
136MST40.29866460
137PRKAA10.29815422
138MAPK140.29386895
139STK30.28919475
140HIPK20.28563791
141EPHB20.28081991
142MAP2K60.24994320
143PAK20.24736047
144TESK10.23142846
145CDK90.21181981
146EGFR0.20882951
147MAPK70.20666844
148GSK3B0.20631238

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.17506148
2Complement and coagulation cascades_Homo sapiens_hsa046103.94247078
3DNA replication_Homo sapiens_hsa030303.72152725
4Base excision repair_Homo sapiens_hsa034103.20657890
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20063257
6Fatty acid biosynthesis_Homo sapiens_hsa000612.80682589
7Spliceosome_Homo sapiens_hsa030402.68303908
8Basal cell carcinoma_Homo sapiens_hsa052172.65236556
9Ribosome_Homo sapiens_hsa030102.51679585
10Hedgehog signaling pathway_Homo sapiens_hsa043402.47541676
11RNA transport_Homo sapiens_hsa030132.43175946
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35150467
13Hippo signaling pathway_Homo sapiens_hsa043902.31803765
14Vitamin digestion and absorption_Homo sapiens_hsa049772.18075479
15One carbon pool by folate_Homo sapiens_hsa006702.06545926
16Folate biosynthesis_Homo sapiens_hsa007902.05433343
17Other glycan degradation_Homo sapiens_hsa005111.91062808
18Biosynthesis of amino acids_Homo sapiens_hsa012301.87519799
19Nucleotide excision repair_Homo sapiens_hsa034201.85306347
20Homologous recombination_Homo sapiens_hsa034401.83779410
21mRNA surveillance pathway_Homo sapiens_hsa030151.76153124
22Arginine and proline metabolism_Homo sapiens_hsa003301.70869251
23Sulfur relay system_Homo sapiens_hsa041221.65081701
24Cell cycle_Homo sapiens_hsa041101.64392753
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63878657
26Fanconi anemia pathway_Homo sapiens_hsa034601.62673844
27Adherens junction_Homo sapiens_hsa045201.61523450
28p53 signaling pathway_Homo sapiens_hsa041151.55013650
29Bladder cancer_Homo sapiens_hsa052191.54763059
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50652821
31PPAR signaling pathway_Homo sapiens_hsa033201.49642659
32Fructose and mannose metabolism_Homo sapiens_hsa000511.46891587
33Fatty acid degradation_Homo sapiens_hsa000711.45882969
34Notch signaling pathway_Homo sapiens_hsa043301.39530858
35N-Glycan biosynthesis_Homo sapiens_hsa005101.38247535
36Phenylalanine metabolism_Homo sapiens_hsa003601.37917218
37Histidine metabolism_Homo sapiens_hsa003401.34871918
38Wnt signaling pathway_Homo sapiens_hsa043101.28280941
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27708377
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.27189518
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26772361
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24532882
43Tight junction_Homo sapiens_hsa045301.22692228
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21823963
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21661764
46TGF-beta signaling pathway_Homo sapiens_hsa043501.16835993
47RNA polymerase_Homo sapiens_hsa030201.11949893
48mTOR signaling pathway_Homo sapiens_hsa041501.10989675
49Lysine degradation_Homo sapiens_hsa003101.06159447
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05981184
51Starch and sucrose metabolism_Homo sapiens_hsa005001.02562555
52Tyrosine metabolism_Homo sapiens_hsa003501.01672594
53Pyrimidine metabolism_Homo sapiens_hsa002400.98783455
54Thyroid cancer_Homo sapiens_hsa052160.95256181
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95165551
56Arginine biosynthesis_Homo sapiens_hsa002200.94412318
57Glutathione metabolism_Homo sapiens_hsa004800.91522799
58Fat digestion and absorption_Homo sapiens_hsa049750.90929956
59RNA degradation_Homo sapiens_hsa030180.88141027
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87662456
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87294590
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85129002
63Propanoate metabolism_Homo sapiens_hsa006400.84991555
64Bile secretion_Homo sapiens_hsa049760.84265238
65MicroRNAs in cancer_Homo sapiens_hsa052060.83682136
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83483137
67Fatty acid elongation_Homo sapiens_hsa000620.82805575
68Galactose metabolism_Homo sapiens_hsa000520.82767908
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81946103
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.81022990
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.80609891
72Selenocompound metabolism_Homo sapiens_hsa004500.80255576
73Fatty acid metabolism_Homo sapiens_hsa012120.79280357
74ABC transporters_Homo sapiens_hsa020100.78804488
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.78474472
76Thyroid hormone synthesis_Homo sapiens_hsa049180.77846076
77Carbon metabolism_Homo sapiens_hsa012000.75789098
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.75128578
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72964560
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71369299
81Basal transcription factors_Homo sapiens_hsa030220.71082105
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69037939
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67122431
84Peroxisome_Homo sapiens_hsa041460.65468053
85Colorectal cancer_Homo sapiens_hsa052100.63694584
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62558257
87Proteasome_Homo sapiens_hsa030500.61533696
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60702150
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59962790
90Oocyte meiosis_Homo sapiens_hsa041140.58657344
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58270488
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56331600
93Sphingolipid metabolism_Homo sapiens_hsa006000.56316825
94Glycerolipid metabolism_Homo sapiens_hsa005610.56056745
95Proteoglycans in cancer_Homo sapiens_hsa052050.55428160
96Melanoma_Homo sapiens_hsa052180.55045501
97Mineral absorption_Homo sapiens_hsa049780.53774924
98Metabolic pathways_Homo sapiens_hsa011000.53260415
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52840330
100Pathways in cancer_Homo sapiens_hsa052000.52484324
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.51200341
102Tryptophan metabolism_Homo sapiens_hsa003800.50124022
103HTLV-I infection_Homo sapiens_hsa051660.49425333
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.48541692
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48397552
106Small cell lung cancer_Homo sapiens_hsa052220.48238575
107Viral carcinogenesis_Homo sapiens_hsa052030.45439789
108Pentose phosphate pathway_Homo sapiens_hsa000300.44858894
109Butanoate metabolism_Homo sapiens_hsa006500.44645312
110Non-homologous end-joining_Homo sapiens_hsa034500.44605772
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44181813
112ECM-receptor interaction_Homo sapiens_hsa045120.43544752
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42307624
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41837459
115Glucagon signaling pathway_Homo sapiens_hsa049220.41273190
116Nitrogen metabolism_Homo sapiens_hsa009100.40177528
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39898009
118Melanogenesis_Homo sapiens_hsa049160.38894983
119Vitamin B6 metabolism_Homo sapiens_hsa007500.38211660
120Protein export_Homo sapiens_hsa030600.37054553
121Endometrial cancer_Homo sapiens_hsa052130.35894190
122Pyruvate metabolism_Homo sapiens_hsa006200.35821079
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35037553
124Renin-angiotensin system_Homo sapiens_hsa046140.34697495
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.34050804
126VEGF signaling pathway_Homo sapiens_hsa043700.33617525
127Retinol metabolism_Homo sapiens_hsa008300.30908051
128AMPK signaling pathway_Homo sapiens_hsa041520.29894209
129Chemical carcinogenesis_Homo sapiens_hsa052040.29611839
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29572793
131Steroid biosynthesis_Homo sapiens_hsa001000.29385570
132Shigellosis_Homo sapiens_hsa051310.29190836
133Arachidonic acid metabolism_Homo sapiens_hsa005900.28617736
134Protein digestion and absorption_Homo sapiens_hsa049740.28595299
135Rap1 signaling pathway_Homo sapiens_hsa040150.27585834
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25746688
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25712092
138Linoleic acid metabolism_Homo sapiens_hsa005910.24788822

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