SP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)7.66550410
2hair cycle (GO:0042633)7.66550410
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.36403199
4doxorubicin metabolic process (GO:0044598)6.79885175
5daunorubicin metabolic process (GO:0044597)6.79885175
6polyketide metabolic process (GO:0030638)6.79885175
7negative regulation of epidermis development (GO:0045683)6.16734026
8protein localization to kinetochore (GO:0034501)5.72023948
9regulation of transforming growth factor beta2 production (GO:0032909)5.42366080
10establishment of skin barrier (GO:0061436)5.34788883
11maintenance of protein location in nucleus (GO:0051457)5.34154567
12branching involved in salivary gland morphogenesis (GO:0060445)5.30206654
13positive regulation of hair follicle development (GO:0051798)5.28760492
14positive regulation of hair cycle (GO:0042635)5.28760492
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.21093366
16regulation of mammary gland epithelial cell proliferation (GO:0033599)5.20191038
17polarized epithelial cell differentiation (GO:0030859)5.16963855
18paraxial mesoderm development (GO:0048339)5.16063061
19somite rostral/caudal axis specification (GO:0032525)5.09421809
20negative regulation of epidermal cell differentiation (GO:0045605)4.98919453
21notochord development (GO:0030903)4.90270538
22regulation of water loss via skin (GO:0033561)4.88907328
23regulation of nuclear cell cycle DNA replication (GO:0033262)4.88195811
24regulation of response to osmotic stress (GO:0047484)4.85132274
25regulation of telomere maintenance via telomerase (GO:0032210)4.75770349
26muscle organ morphogenesis (GO:0048644)4.75366151
27histone H4-K5 acetylation (GO:0043981)4.62920703
28histone H4-K8 acetylation (GO:0043982)4.62920703
29negative regulation of cell cycle G2/M phase transition (GO:1902750)4.62807036
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.57980290
31protein localization to chromosome, centromeric region (GO:0071459)4.57454669
32rRNA transcription (GO:0009303)4.55982778
33desmosome organization (GO:0002934)4.53927674
34histone H4-K12 acetylation (GO:0043983)4.49911208
35keratinization (GO:0031424)4.49330646
36mitotic sister chromatid segregation (GO:0000070)4.45184528
37hippo signaling (GO:0035329)4.37689503
38intestinal epithelial cell development (GO:0060576)4.36341367
39heterochromatin organization (GO:0070828)4.27854040
40aminoglycoside antibiotic metabolic process (GO:0030647)4.25838461
41negative regulation of telomerase activity (GO:0051974)4.22332352
42cranial suture morphogenesis (GO:0060363)4.21725326
43Golgi transport vesicle coating (GO:0048200)4.20115109
44COPI coating of Golgi vesicle (GO:0048205)4.20115109
45cytoskeletal anchoring at plasma membrane (GO:0007016)4.17016802
46lung-associated mesenchyme development (GO:0060484)4.12808533
47DNA replication checkpoint (GO:0000076)4.10899079
48negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.10575700
49positive regulation of protein kinase C signaling (GO:0090037)4.04201127
50rRNA methylation (GO:0031167)4.00740858
51negative regulation of stem cell proliferation (GO:2000647)3.99156237
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.98270811
53L-alpha-amino acid transmembrane transport (GO:1902475)3.97699319
54rRNA modification (GO:0000154)3.91010410
55negative regulation of keratinocyte proliferation (GO:0010839)3.88063701
56nuclear pore complex assembly (GO:0051292)3.87560630
57bone trabecula formation (GO:0060346)3.87061549
58regulation of translation in response to stress (GO:0043555)3.86495284
59regulation of cardioblast differentiation (GO:0051890)3.86395010
60semaphorin-plexin signaling pathway (GO:0071526)3.86168392
61hormone catabolic process (GO:0042447)3.86082276
62pre-miRNA processing (GO:0031054)3.85048063
63regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.81067029
64positive regulation of epidermis development (GO:0045684)3.75607086
65regulation of cilium movement (GO:0003352)3.73362951
66sister chromatid segregation (GO:0000819)3.72407038
67chromatin assembly (GO:0031497)3.70068809
68planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68963931
69regulation of hippo signaling (GO:0035330)3.68288580
70hair follicle morphogenesis (GO:0031069)3.67468074
71epithelial cell-cell adhesion (GO:0090136)3.66831030
72positive regulation of DNA-dependent DNA replication (GO:2000105)3.66359954
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.65319703
74regulation of MHC class I biosynthetic process (GO:0045343)3.64970524
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.64337764
76establishment of apical/basal cell polarity (GO:0035089)3.64215729
77DNA replication-dependent nucleosome organization (GO:0034723)3.63213001
78DNA replication-dependent nucleosome assembly (GO:0006335)3.63213001
79keratinocyte development (GO:0003334)3.61791084
80wound healing, spreading of epidermal cells (GO:0035313)3.61629385
81nuclear pore organization (GO:0006999)3.56224139
82trophectodermal cell differentiation (GO:0001829)3.53614854
83ribosome biogenesis (GO:0042254)3.53313322
84regulation of apoptotic process involved in morphogenesis (GO:1902337)3.51909473
85epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.51363401
86regulation of posttranscriptional gene silencing (GO:0060147)3.48096396
87regulation of gene silencing by miRNA (GO:0060964)3.48096396
88regulation of gene silencing by RNA (GO:0060966)3.48096396
89outflow tract septum morphogenesis (GO:0003148)3.48005415
90histone H4-K16 acetylation (GO:0043984)3.46447214
91intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.45954765
92cell fate commitment involved in formation of primary germ layer (GO:0060795)3.44200579
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40314373
94cell differentiation involved in embryonic placenta development (GO:0060706)3.38502166
95multicellular organismal water homeostasis (GO:0050891)3.37413755
96regulation of keratinocyte proliferation (GO:0010837)3.34842484
97negative regulation of telomere maintenance (GO:0032205)3.34824492
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34822919
99tooth mineralization (GO:0034505)3.34678487
100regulation of keratinocyte differentiation (GO:0045616)3.33028813
101gap junction assembly (GO:0016264)3.30545500
102positive regulation of Cdc42 GTPase activity (GO:0043089)3.29666419
103intermediate filament organization (GO:0045109)3.28633762
104morphogenesis of embryonic epithelium (GO:0016331)3.28568559
105atrioventricular valve morphogenesis (GO:0003181)3.28231551
106trophoblast giant cell differentiation (GO:0060707)3.27826763
107primitive streak formation (GO:0090009)3.27526013
108cytidine metabolic process (GO:0046087)3.27388938
109cytidine catabolic process (GO:0006216)3.27388938
110cytidine deamination (GO:0009972)3.27388938
111non-canonical Wnt signaling pathway (GO:0035567)3.23252249
112positive regulation of odontogenesis (GO:0042482)3.22631116
113adherens junction assembly (GO:0034333)3.22451720
114post-embryonic morphogenesis (GO:0009886)3.20247686
115cell surface receptor signaling pathway involved in heart development (GO:0061311)3.19751604
116icosanoid secretion (GO:0032309)3.19557927
117arachidonic acid secretion (GO:0050482)3.19557927
118retinoic acid receptor signaling pathway (GO:0048384)3.18393628
119osteoblast development (GO:0002076)3.17494493
120mitotic chromosome condensation (GO:0007076)3.17149730
121positive regulation of insulin receptor signaling pathway (GO:0046628)3.12321477
122regulation of epidermis development (GO:0045682)3.10719889
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08978409
124transcription from mitochondrial promoter (GO:0006390)3.07993233
125regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.07736625
126RNA stabilization (GO:0043489)3.07521375
127mRNA stabilization (GO:0048255)3.07521375
128ectoderm development (GO:0007398)3.05825656
129phosphatidylinositol acyl-chain remodeling (GO:0036149)3.05026974
130cell-substrate adherens junction assembly (GO:0007045)3.03798327
131focal adhesion assembly (GO:0048041)3.03798327
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.02220076
133epithelial cell differentiation involved in prostate gland development (GO:0060742)3.02162092
134cell-substrate junction assembly (GO:0007044)3.01222343
135hemidesmosome assembly (GO:0031581)2.99332151
136craniofacial suture morphogenesis (GO:0097094)2.98968213
137formation of translation preinitiation complex (GO:0001731)2.97788098
138protein localization to endosome (GO:0036010)2.97117332
139branching involved in labyrinthine layer morphogenesis (GO:0060670)2.96357223
140regulation of hair follicle development (GO:0051797)2.95095594
141establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.94499753
142phenol-containing compound catabolic process (GO:0019336)2.94248467
143activation of Rac GTPase activity (GO:0032863)2.94218620
144keratinocyte proliferation (GO:0043616)2.93560037
145positive regulation of hormone metabolic process (GO:0032352)2.92759362
146positive regulation of hormone biosynthetic process (GO:0046886)2.92165379
147vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.91880654
148embryonic process involved in female pregnancy (GO:0060136)2.91094127
149wound healing, spreading of cells (GO:0044319)2.89566804
150pore complex assembly (GO:0046931)2.89065602
151microtubule severing (GO:0051013)2.88731274
152DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.88049746
153response to dietary excess (GO:0002021)2.86649514
154establishment or maintenance of monopolar cell polarity (GO:0061339)2.86635186
155establishment of monopolar cell polarity (GO:0061162)2.86635186
156response to vitamin A (GO:0033189)2.86409728
157tight junction assembly (GO:0070830)2.83749991
158mitotic metaphase plate congression (GO:0007080)2.82521100
159negative regulation of catenin import into nucleus (GO:0035414)2.82342388
160DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81880165
161nucleoside transmembrane transport (GO:1901642)2.80969105
162cell-cell junction assembly (GO:0007043)2.80721673
163maintenance of protein localization in organelle (GO:0072595)2.79299258
164endocrine hormone secretion (GO:0060986)2.78801426
165maternal placenta development (GO:0001893)2.77645034
166keratinocyte differentiation (GO:0030216)2.77540542
167negative regulation of cell fate specification (GO:0009996)2.77409894
168vitamin A metabolic process (GO:0006776)2.77300301
169tachykinin receptor signaling pathway (GO:0007217)2.76742652
170establishment or maintenance of apical/basal cell polarity (GO:0035088)2.75217171
171establishment or maintenance of bipolar cell polarity (GO:0061245)2.75217171
172anterior/posterior axis specification (GO:0009948)2.75002613
173interferon-gamma production (GO:0032609)2.74915213
174positive regulation of epidermal cell differentiation (GO:0045606)2.73740678
1754-hydroxyproline metabolic process (GO:0019471)2.72231402
176regulation of hair cycle (GO:0042634)2.71684352
177protein retention in ER lumen (GO:0006621)2.70913213
178homocysteine metabolic process (GO:0050667)2.69631631
179cornea development in camera-type eye (GO:0061303)2.69035658
180vitamin transmembrane transport (GO:0035461)2.68522595
181Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68468638
182apical protein localization (GO:0045176)2.66618297
183regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66088158
184regulation of epidermal cell differentiation (GO:0045604)2.65685151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.68036437
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.68036437
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.68036437
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.14821910
5ZNF263_19887448_ChIP-Seq_K562_Human5.01552492
6E2F7_22180533_ChIP-Seq_HELA_Human4.39446916
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.42542963
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.39600693
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.88797775
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82515697
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.64921842
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56554680
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.55148992
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.52449649
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.48942909
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48800910
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.40156931
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.31900881
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.30711831
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21557968
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16198362
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.05848839
23LXR_22292898_ChIP-Seq_THP-1_Human2.00876144
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92457275
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90795368
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88833266
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86614851
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86352840
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81514064
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81400343
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77537491
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77194372
33NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76231473
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75858015
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74040415
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73023391
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.71969913
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71249624
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.71041250
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68745247
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.68215371
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64429776
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62638494
44TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.61295048
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59045099
46NANOG_18692474_ChIP-Seq_MESCs_Mouse1.57270835
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51649253
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50629249
49NANOG_18692474_ChIP-Seq_MEFs_Mouse1.50071849
50PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.49989606
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.48458559
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46742031
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44512883
54POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38836770
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.35074352
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34869076
57MYC_22102868_ChIP-Seq_BL_Human1.34466841
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30990087
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29001590
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29001590
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28719889
62CLOCK_20551151_ChIP-Seq_293T_Human1.28116339
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.28004549
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24729123
65* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24372026
66KLF5_25053715_ChIP-Seq_YYC3_Human1.24141558
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24077797
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22688077
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22667182
70SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22592362
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20620800
72RACK7_27058665_Chip-Seq_MCF-7_Human1.19277561
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18965705
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18672747
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.17810536
76IRF1_19129219_ChIP-ChIP_H3396_Human1.16672941
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16541911
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.16367746
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15757306
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15261971
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15070789
82GATA4_25053715_ChIP-Seq_YYC3_Human1.14025625
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13415137
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13405842
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12320439
86AR_21909140_ChIP-Seq_LNCAP_Human1.12191399
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11694166
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11528960
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11278565
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.11183333
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10097919
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09362766
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.09089406
94ATF3_27146783_Chip-Seq_COLON_Human1.08926743
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08388988
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08258702
97ELF5_23300383_ChIP-Seq_T47D_Human1.08136478
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08007155
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.07713954
100KAP1_27257070_Chip-Seq_ESCs_Mouse1.05763429
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04470649
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04449587
103E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03556383
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02691083
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02253411
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01858294
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01809244
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.01429874
109SOX2_20726797_ChIP-Seq_SW620_Human1.01184556
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.00868880
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.00362195
112NANOG_16518401_ChIP-PET_MESCs_Mouse0.99737928
113P68_20966046_ChIP-Seq_HELA_Human0.99574865
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98621301
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97545639
116TCF7_22412390_ChIP-Seq_EML_Mouse0.97011812
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96373898
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94920215
119XRN2_22483619_ChIP-Seq_HELA_Human0.94639708
120* TET1_21451524_ChIP-Seq_MESCs_Mouse0.94531110
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.94200310
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94047464
123TP53_22127205_ChIP-Seq_IMR90_Human0.93826647
124VDR_21846776_ChIP-Seq_THP-1_Human0.93324236
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93235074
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92891428
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92842889
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92102048
129* NCOR1_26117541_ChIP-Seq_K562_Human0.90751023
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90416178
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89969999
132CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89916674
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89498344
134BCOR_27268052_Chip-Seq_Bcells_Human0.86592074
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85751512
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85161639
137* SMC4_20622854_ChIP-Seq_HELA_Human0.85014431
138GATA6_25053715_ChIP-Seq_YYC3_Human0.84518432
139PHF8_20622854_ChIP-Seq_HELA_Human0.84352359
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83377320
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.81814673
142EGR1_19374776_ChIP-ChIP_THP-1_Human0.80695291
143KDM5A_27292631_Chip-Seq_BREAST_Human0.80577543
144* TP63_22573176_ChIP-Seq_HFKS_Human0.80246373
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.79590316
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78934528
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78854254
148* KDM2B_26808549_Chip-Seq_K562_Human0.78417790
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.78242414
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77967849
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.76533152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.83102424
2MP0005377_hearing/vestibular/ear_phenot4.83102424
3MP0002254_reproductive_system_inflammat4.31892641
4MP0002796_impaired_skin_barrier4.00257447
5MP0000566_synostosis3.53539370
6MP0004264_abnormal_extraembryonic_tissu3.32640540
7MP0010234_abnormal_vibrissa_follicle2.94262008
8MP0003705_abnormal_hypodermis_morpholog2.89053035
9MP0003011_delayed_dark_adaptation2.86990766
10MP0000383_abnormal_hair_follicle2.80830547
11MP0006292_abnormal_olfactory_placode2.77105878
12MP0005076_abnormal_cell_differentiation2.67563260
13MP0000579_abnormal_nail_morphology2.61616412
14MP0008057_abnormal_DNA_replication2.56993961
15MP0003890_abnormal_embryonic-extraembry2.51774104
16* MP0002098_abnormal_vibrissa_morphology2.50633906
17MP0005275_abnormal_skin_tensile2.49230745
18MP0005501_abnormal_skin_physiology2.49204250
19MP0010678_abnormal_skin_adnexa2.48407530
20MP0005257_abnormal_intraocular_pressure2.48058659
21MP0004957_abnormal_blastocyst_morpholog2.41524620
22MP0004381_abnormal_hair_follicle2.29720350
23MP0005499_abnormal_olfactory_system2.21816186
24MP0005394_taste/olfaction_phenotype2.21816186
25MP0004782_abnormal_surfactant_physiolog2.21375306
26MP0010030_abnormal_orbit_morphology2.21122594
27MP0002653_abnormal_ependyma_morphology2.11006861
28MP0003941_abnormal_skin_development2.09643762
29* MP0000647_abnormal_sebaceous_gland2.07625446
30MP0005075_abnormal_melanosome_morpholog1.92767166
31MP0000762_abnormal_tongue_morphology1.91574063
32* MP0000377_abnormal_hair_follicle1.90863707
33MP0010352_gastrointestinal_tract_polyps1.90565127
34MP0004858_abnormal_nervous_system1.80836377
35MP0000537_abnormal_urethra_morphology1.78591957
36MP0001849_ear_inflammation1.78386574
37* MP0001216_abnormal_epidermal_layer1.67863034
38MP0010307_abnormal_tumor_latency1.66185285
39MP0005380_embryogenesis_phenotype1.61944955
40MP0001672_abnormal_embryogenesis/_devel1.61944955
41MP0003938_abnormal_ear_development1.60587866
42MP0000003_abnormal_adipose_tissue1.54141483
43MP0003111_abnormal_nucleus_morphology1.53055234
44MP0002332_abnormal_exercise_endurance1.52583452
45MP0000350_abnormal_cell_proliferation1.47000759
46MP0002088_abnormal_embryonic_growth/wei1.46395827
47MP0003984_embryonic_growth_retardation1.45781707
48MP0002060_abnormal_skin_morphology1.41749696
49MP0003453_abnormal_keratinocyte_physiol1.41301240
50MP0003077_abnormal_cell_cycle1.40085088
51MP0003693_abnormal_embryo_hatching1.39537815
52MP0009672_abnormal_birth_weight1.37321368
53MP0009053_abnormal_anal_canal1.35073108
54MP0003315_abnormal_perineum_morphology1.34979175
55MP0000427_abnormal_hair_cycle1.33643374
56MP0004272_abnormal_basement_membrane1.32035722
57MP0003755_abnormal_palate_morphology1.29619123
58MP0003942_abnormal_urinary_system1.27792092
59MP0003121_genomic_imprinting1.27681904
60MP0010771_integument_phenotype1.27359768
61MP0003122_maternal_imprinting1.27043594
62MP0008004_abnormal_stomach_pH1.26959886
63MP0001293_anophthalmia1.26889895
64MP0002085_abnormal_embryonic_tissue1.25881146
65MP0002084_abnormal_developmental_patter1.23939267
66MP0002092_abnormal_eye_morphology1.23386546
67MP0004185_abnormal_adipocyte_glucose1.23355805
68* MP0000432_abnormal_head_morphology1.21244742
69MP0003123_paternal_imprinting1.20312165
70MP0003385_abnormal_body_wall1.19504110
71MP0005375_adipose_tissue_phenotype1.19411603
72MP0002233_abnormal_nose_morphology1.19158187
73MP0000678_abnormal_parathyroid_gland1.18928794
74MP0002086_abnormal_extraembryonic_tissu1.18562151
75MP0000428_abnormal_craniofacial_morphol1.17992382
76MP0001730_embryonic_growth_arrest1.16968119
77MP0002277_abnormal_respiratory_mucosa1.14663025
78MP0000516_abnormal_urinary_system1.14125607
79MP0005367_renal/urinary_system_phenotyp1.14125607
80* MP0003935_abnormal_craniofacial_develop1.13621127
81MP0010094_abnormal_chromosome_stability1.13249871
82MP0001243_abnormal_dermal_layer1.12655437
83MP0005409_darkened_coat_color1.12609176
84MP0008789_abnormal_olfactory_epithelium1.10409187
85MP0002127_abnormal_cardiovascular_syste1.08176328
86MP0002697_abnormal_eye_size1.07323836
87MP0004019_abnormal_vitamin_homeostasis1.07231307
88MP0002932_abnormal_joint_morphology1.07132303
89MP0003567_abnormal_fetal_cardiomyocyte1.05045675
90MP0005451_abnormal_body_composition1.03616788
91MP0003937_abnormal_limbs/digits/tail_de1.02830888
92MP0008961_abnormal_basal_metabolism1.01064455
93MP0006035_abnormal_mitochondrial_morpho1.00547338
94MP0008007_abnormal_cellular_replicative0.97615096
95MP0004197_abnormal_fetal_growth/weight/0.97150545
96MP0000049_abnormal_middle_ear0.95948197
97MP0005666_abnormal_adipose_tissue0.95049978
98MP0001697_abnormal_embryo_size0.91614582
99MP0004947_skin_inflammation0.91453970
100MP0000467_abnormal_esophagus_morphology0.91010826
101* MP0000367_abnormal_coat/_hair0.90597228
102MP0002396_abnormal_hematopoietic_system0.90396810
103MP0001346_abnormal_lacrimal_gland0.89891730
104MP0001881_abnormal_mammary_gland0.89446427
105MP0003119_abnormal_digestive_system0.87860485
106MP0003136_yellow_coat_color0.86437250
107MP0005508_abnormal_skeleton_morphology0.85744458
108MP0002249_abnormal_larynx_morphology0.85661622
109MP0002877_abnormal_melanocyte_morpholog0.85036888
110MP0000534_abnormal_ureter_morphology0.84128964
111* MP0009931_abnormal_skin_appearance0.83138841
112MP0002114_abnormal_axial_skeleton0.83060704
113MP0003936_abnormal_reproductive_system0.81592006
114MP0008932_abnormal_embryonic_tissue0.80666931
115MP0001286_abnormal_eye_development0.79652110
116MP0002111_abnormal_tail_morphology0.78477369
117MP0001340_abnormal_eyelid_morphology0.78068684
118MP0005083_abnormal_biliary_tract0.77985577
119MP0003566_abnormal_cell_adhesion0.77129953
120MP0002080_prenatal_lethality0.76803516
121MP0004233_abnormal_muscle_weight0.74747927
122MP0000750_abnormal_muscle_regeneration0.74501595
123MP0005248_abnormal_Harderian_gland0.74369660
124MP0001348_abnormal_lacrimal_gland0.74277474
125MP0003115_abnormal_respiratory_system0.73073467
126MP0009703_decreased_birth_body0.72800207
127MP0005023_abnormal_wound_healing0.72348380
128MP0005197_abnormal_uvea_morphology0.71910655
129MP0009333_abnormal_splenocyte_physiolog0.71193519
130MP0002896_abnormal_bone_mineralization0.70682383
131MP0003879_abnormal_hair_cell0.70344126
132MP0005391_vision/eye_phenotype0.69030515
133MP0002116_abnormal_craniofacial_bone0.68473038
134MP0002970_abnormal_white_adipose0.67816707
135MP0009115_abnormal_fat_cell0.67415397
136MP0000462_abnormal_digestive_system0.65476027
137MP0000627_abnormal_mammary_gland0.64234228
138MP0000477_abnormal_intestine_morphology0.64159008
139MP0008260_abnormal_autophagy0.63943358
140MP0009379_abnormal_foot_pigmentation0.63424562
141MP0005670_abnormal_white_adipose0.57534193

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.77303129
2Hypotrichosis (HP:0001006)5.32939288
3Hypochromic microcytic anemia (HP:0004840)4.88792205
4Aplasia cutis congenita (HP:0001057)4.30381686
5Multiple enchondromatosis (HP:0005701)4.13719879
6Rib fusion (HP:0000902)4.11944983
7Bilateral sensorineural hearing impairment (HP:0008619)3.91221604
8Asymmetry of the thorax (HP:0001555)3.90477442
9Ependymoma (HP:0002888)3.83078579
10Hepatoblastoma (HP:0002884)3.75784208
11Abnormality of dental color (HP:0011073)3.75233230
12Abnormality of nail color (HP:0100643)3.66640874
13Woolly hair (HP:0002224)3.65826918
14Pili torti (HP:0003777)3.57473275
15Abnormality of the lower motor neuron (HP:0002366)3.56119968
16Advanced eruption of teeth (HP:0006288)3.45061598
17Sparse eyelashes (HP:0000653)3.42720655
18Absent eyelashes (HP:0000561)3.22111603
19Neoplasm of striated muscle (HP:0009728)3.16700867
20Pterygium (HP:0001059)3.15137803
21Amelogenesis imperfecta (HP:0000705)3.12300995
22Septate vagina (HP:0001153)3.05561157
23Bicornuate uterus (HP:0000813)2.97750629
24Abnormality of the parietal bone (HP:0002696)2.97249084
25Concave nail (HP:0001598)2.96974669
26Abnormality of the salivary glands (HP:0010286)2.95890829
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94959205
28Trismus (HP:0000211)2.94296744
29Myelomeningocele (HP:0002475)2.93629078
30Rhabdomyosarcoma (HP:0002859)2.88464001
31Absent eyebrow (HP:0002223)2.88441796
32Ridged nail (HP:0001807)2.86472025
33Abnormality of the astrocytes (HP:0100707)2.81681766
34Astrocytoma (HP:0009592)2.81681766
35Nail dystrophy (HP:0008404)2.80307854
36Fragile nails (HP:0001808)2.77785227
37Bifid tongue (HP:0010297)2.76593167
38Renal tubular acidosis (HP:0001947)2.74403335
39Choanal stenosis (HP:0000452)2.69295062
40Fused cervical vertebrae (HP:0002949)2.66257215
41High anterior hairline (HP:0009890)2.64995085
42Nephroblastoma (Wilms tumor) (HP:0002667)2.62118795
43Partial duplication of thumb phalanx (HP:0009944)2.62025939
44Onycholysis (HP:0001806)2.60827756
45Testicular atrophy (HP:0000029)2.57625676
46Abnormality of permanent molar morphology (HP:0011071)2.55147518
47Abnormality of the dental root (HP:0006486)2.55147518
48Taurodontia (HP:0000679)2.55147518
49Metaphyseal cupping (HP:0003021)2.55111377
50Ankyloglossia (HP:0010296)2.54138495
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.52776428
52Hypoplasia of the fovea (HP:0007750)2.52776428
53Preauricular pit (HP:0004467)2.52278875
54Periauricular skin pits (HP:0100277)2.52278875
55Widely patent fontanelles and sutures (HP:0004492)2.52219151
56Abnormality of the lacrimal duct (HP:0011481)2.51219671
57Abnormal lung lobation (HP:0002101)2.49354967
58Aplasia/hypoplasia of the humerus (HP:0006507)2.49284141
59Rectal fistula (HP:0100590)2.48326841
60Rectovaginal fistula (HP:0000143)2.48326841
61Skin pits (HP:0100276)2.47220483
62Chromsome breakage (HP:0040012)2.46800569
63Short humerus (HP:0005792)2.44082549
64Brittle hair (HP:0002299)2.44009074
65Esophageal varix (HP:0002040)2.42747504
66Hypoparathyroidism (HP:0000829)2.41207630
67Shawl scrotum (HP:0000049)2.40457971
68Impulsivity (HP:0100710)2.40148958
69Embryonal renal neoplasm (HP:0011794)2.39146475
70Abnormal tarsal ossification (HP:0008369)2.38585268
71Anomalous pulmonary venous return (HP:0010772)2.36881656
72Aplasia of the musculature (HP:0100854)2.36231889
73Intestinal fistula (HP:0100819)2.36218727
74Abnormality of molar (HP:0011077)2.34569060
75Abnormality of molar morphology (HP:0011070)2.34569060
76Cone-rod dystrophy (HP:0000548)2.33866133
77Preauricular skin tag (HP:0000384)2.33683131
78Partial duplication of the phalanx of hand (HP:0009999)2.32025521
79Cervical subluxation (HP:0003308)2.31975363
80Milia (HP:0001056)2.26861559
81Lip pit (HP:0100267)2.26815233
82Alopecia of scalp (HP:0002293)2.23810510
83Breast hypoplasia (HP:0003187)2.22625813
84Increased connective tissue (HP:0009025)2.22349512
85Paralysis (HP:0003470)2.21483265
86Curly hair (HP:0002212)2.21005312
87Premature ovarian failure (HP:0008209)2.20981616
88Thick nail (HP:0001805)2.19564808
89Abnormality of chromosome segregation (HP:0002916)2.19091331
90Skin tags (HP:0010609)2.18220397
91Abnormality of the labia majora (HP:0012881)2.16821378
92Abnormality of the distal phalanx of the thumb (HP:0009617)2.16017843
93Increased IgE level (HP:0003212)2.15993565
94Abnormality of the phalanges of the hallux (HP:0010057)2.15646511
95Flat acetabular roof (HP:0003180)2.15504138
96Ventricular tachycardia (HP:0004756)2.15335192
97Abnormality of the dental pulp (HP:0006479)2.15067057
98Hypochromic anemia (HP:0001931)2.15014033
99Slow-growing hair (HP:0002217)2.14842494
100Abnormality of hair growth rate (HP:0011363)2.14842494
101Short 5th finger (HP:0009237)2.14249658
102Aplasia/Hypoplasia of the clavicles (HP:0006710)2.13532543
103Plantar hyperkeratosis (HP:0007556)2.12569834
104Horizontal nystagmus (HP:0000666)2.12294152
105Glioma (HP:0009733)2.11519004
106Supernumerary spleens (HP:0009799)2.10969355
107Pendular nystagmus (HP:0012043)2.10894984
108Vaginal fistula (HP:0004320)2.09194035
109Abnormality of the pulmonary veins (HP:0011718)2.09186052
110Acanthosis nigricans (HP:0000956)2.07971039
111Nasolacrimal duct obstruction (HP:0000579)2.06427924
112Meckel diverticulum (HP:0002245)2.06272287
113Short clavicles (HP:0000894)2.06098827
114Abnormality of the nasolacrimal system (HP:0000614)2.04424617
115Delayed epiphyseal ossification (HP:0002663)2.03783214
116Large earlobe (HP:0009748)2.03396275
117Abnormality of small intestinal villus morphology (HP:0011472)2.02255403
118Villous atrophy (HP:0011473)2.02255403
119Abnormality of the distal phalanges of the toes (HP:0010182)2.00836994
120Proximal tubulopathy (HP:0000114)2.00706509
121Ankle contracture (HP:0006466)2.00458299
122Abnormal cartilage morphology (HP:0002763)1.99063142
123Selective tooth agenesis (HP:0001592)1.97012176
124Sparse scalp hair (HP:0002209)1.94434172
125Abnormality of the ileum (HP:0001549)1.94097591
126Fragile skin (HP:0001030)1.93381095
127Atrophic scars (HP:0001075)1.91796464
128Short middle phalanx of the 5th finger (HP:0004220)1.91679794
129Absent hair (HP:0002298)1.91326962
130Diaphragmatic weakness (HP:0009113)1.90719036
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90544395
132Congenital ichthyosiform erythroderma (HP:0007431)1.90296727
133Neonatal death (HP:0003811)1.89872059
134Abnormality of the gastric mucosa (HP:0004295)1.89831251
135Progressive muscle weakness (HP:0003323)1.89336208
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.87921401
137Long palpebral fissure (HP:0000637)1.87064177
138Palmoplantar hyperkeratosis (HP:0000972)1.86971511
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.86487111
140Right ventricular cardiomyopathy (HP:0011663)1.86297334
141Atresia of the external auditory canal (HP:0000413)1.84833982
142Achilles tendon contracture (HP:0001771)1.83796786
143Tetraplegia (HP:0002445)1.83526158
144Abnormality of oral frenula (HP:0000190)1.82959490
145Palmar hyperkeratosis (HP:0010765)1.81737403
146Wide cranial sutures (HP:0010537)1.80844775
147Malnutrition (HP:0004395)1.80580172
148Natal tooth (HP:0000695)1.80298989
149Hypoplastic labia majora (HP:0000059)1.79861601
150Abnormal hair laboratory examination (HP:0003328)1.79680793
151Amyotrophic lateral sclerosis (HP:0007354)1.79667875
152Abnormality of the preputium (HP:0100587)1.79107635
153Abnormal foot bone ossification (HP:0010675)1.77776951
154Neoplasm of the heart (HP:0100544)1.77465852
155Seborrheic dermatitis (HP:0001051)1.77248359
156Abnormality of the fovea (HP:0000493)1.76602673
157Visceral angiomatosis (HP:0100761)1.76482259
158Abnormality of the musculature of the hand (HP:0001421)1.75006491
159Oligodontia (HP:0000677)1.72265855
160Abnormality of the aortic arch (HP:0012303)1.71029702
161Bronchomalacia (HP:0002780)1.67181743
162Tetany (HP:0001281)1.65557439
163Anonychia (HP:0001798)1.61511765
164Pallor (HP:0000980)1.60797083
165Distal lower limb muscle weakness (HP:0009053)1.60499093
166Split foot (HP:0001839)1.59565234
167Abnormality of carpal bone ossification (HP:0006257)1.58448993
168Hypoplasia of dental enamel (HP:0006297)1.55697530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.00033661
2NME14.55795695
3GRK54.53694461
4GRK63.60499526
5ERN13.60431520
6GRK12.89080694
7STK392.66419458
8TTK2.64269197
9TYRO32.60893205
10ADRBK22.56690053
11NME22.36972133
12STK102.28494088
13LATS22.25432768
14SIK12.20164463
15WNK42.19847546
16TGFBR22.17222530
17LATS12.12031949
18EPHA22.06345229
19TRIB32.05941355
20CSF1R1.95689154
21CDK71.89435476
22STK38L1.80584803
23MAPK71.78877712
24MATK1.69817875
25OXSR11.61587957
26GRK71.60968201
27AKT31.59879730
28NEK21.48619588
29MOS1.46990128
30MAPKAPK31.44258536
31CHEK21.42758306
32WNK11.41677931
33RPS6KA41.29839379
34SMG11.29823496
35FGFR31.26915871
36PLK11.20750290
37MARK21.20328459
38MAP3K101.10834000
39RPS6KB21.08422915
40BUB11.07659016
41CAMK41.02920780
42TAOK11.01313821
43RIPK11.00331181
44CDC70.99899675
45PKN20.99848315
46PAK40.98220279
47IRAK30.97069270
48CHEK10.96247713
49EIF2AK10.94714800
50DYRK30.94363513
51STK30.94303983
52FER0.94257874
53HIPK20.92049115
54ALK0.91171669
55MAP3K30.89743026
56STK380.86382539
57PRKG20.84575722
58WEE10.83797585
59ADRBK10.83490903
60MTOR0.80433536
61MST1R0.79747105
62PTK60.78339638
63EPHB20.77654304
64NTRK10.76938567
65CDK40.75558584
66AURKB0.75090351
67AKT20.74689756
68LRRK20.72612863
69SRPK10.70602625
70PRKCI0.69466209
71LMTK20.67838380
72MAP2K40.66247922
73MAP2K10.65207587
74AURKA0.64513447
75PBK0.62885133
76STK240.62061687
77ACVR1B0.61377785
78MAP2K60.61367054
79PLK40.61144057
80CDK20.59852695
81MAP3K70.59150902
82FGR0.56692982
83PTK20.54812654
84PDGFRA0.54259938
85SCYL20.53634020
86BRD40.52251002
87EEF2K0.47332293
88ATM0.47116379
89FGFR40.47040657
90MAP3K20.46399148
91BRAF0.46263896
92CSNK1E0.44153331
93MAPK120.43040301
94ERBB20.41094263
95EIF2AK20.40765162
96FGFR10.40408016
97MAP3K90.39782744
98EPHB10.39346552
99ICK0.38159896
100BRSK20.37055217
101CDK80.36827939
102ARAF0.36810057
103DAPK10.36323844
104TESK10.35740866
105MET0.35591183
106RPS6KA20.34983005
107CDK10.34744577
108CSK0.33671666
109KDR0.32848032
110MAPK100.32605086
111PRKD20.32262286
112PAK10.31684558
113MELK0.31481664
114RPS6KC10.31219005
115RPS6KL10.31219005
116CDK60.31150807
117TRPM70.30199042
118NEK10.29751202
119MAP3K80.29392836
120ITK0.29368244
121MAPKAPK20.28863204
122BMX0.28685168
123DYRK1B0.28476478
124KSR20.27681839
125ILK0.27035975
126DYRK20.26425866
127DDR20.25856465
128CDC42BPA0.25669291
129IGF1R0.25214297
130MST40.24983458
131MAP3K60.24897646
132DAPK20.24873862
133MAPK140.24437781
134GSK3B0.24302148
135PAK30.24295046
136TESK20.23639615
137DYRK1A0.23559523
138EIF2AK30.23353083
139PRKAA10.23121048
140MAPK10.22266357
141MAP2K20.21867130
142RPS6KA10.21664189
143CSNK1D0.20064507
144PDGFRB0.19792453
145BRSK10.19055993
146CAMK2G0.18560692
147NEK60.18100168
148DAPK30.17601091
149RPS6KA60.17257810
150GSK3A0.16115405
151FGFR20.15646749
152TGFBR10.14326893
153YES10.14178149
154ZAP700.13864824

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.94359818
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23364314
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.23232320
4Collecting duct acid secretion_Homo sapiens_hsa049662.91044998
5Linoleic acid metabolism_Homo sapiens_hsa005912.66314643
6Vibrio cholerae infection_Homo sapiens_hsa051102.57971294
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52101145
8Arachidonic acid metabolism_Homo sapiens_hsa005902.39550899
9RNA transport_Homo sapiens_hsa030132.33973911
10Fructose and mannose metabolism_Homo sapiens_hsa000512.10797713
11Thyroid cancer_Homo sapiens_hsa052162.05781821
12Arginine biosynthesis_Homo sapiens_hsa002201.99641522
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.97607795
14Basal cell carcinoma_Homo sapiens_hsa052171.91214417
15Cell cycle_Homo sapiens_hsa041101.91163175
16p53 signaling pathway_Homo sapiens_hsa041151.78107273
17mTOR signaling pathway_Homo sapiens_hsa041501.69112698
18RNA polymerase_Homo sapiens_hsa030201.64677895
19mRNA surveillance pathway_Homo sapiens_hsa030151.61159149
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58938474
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53433357
22Vitamin digestion and absorption_Homo sapiens_hsa049771.50095621
23Hedgehog signaling pathway_Homo sapiens_hsa043401.46507445
24Hippo signaling pathway_Homo sapiens_hsa043901.46047580
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44558615
26N-Glycan biosynthesis_Homo sapiens_hsa005101.43569502
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37948592
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36527082
29Fanconi anemia pathway_Homo sapiens_hsa034601.34347942
30Galactose metabolism_Homo sapiens_hsa000521.34304614
31MicroRNAs in cancer_Homo sapiens_hsa052061.33799740
32Biosynthesis of amino acids_Homo sapiens_hsa012301.33097714
33Fatty acid biosynthesis_Homo sapiens_hsa000611.31876183
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24718378
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.24527990
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24323168
37Ether lipid metabolism_Homo sapiens_hsa005651.21616843
38Spliceosome_Homo sapiens_hsa030401.21431833
39Chronic myeloid leukemia_Homo sapiens_hsa052201.20009324
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15667901
41Basal transcription factors_Homo sapiens_hsa030221.14635433
42Renal cell carcinoma_Homo sapiens_hsa052111.14570215
43Focal adhesion_Homo sapiens_hsa045101.13207465
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11679019
45Bladder cancer_Homo sapiens_hsa052191.09625811
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07981097
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02750087
48Folate biosynthesis_Homo sapiens_hsa007901.01803712
49Insulin signaling pathway_Homo sapiens_hsa049101.00080223
50Adherens junction_Homo sapiens_hsa045201.00004086
51Amoebiasis_Homo sapiens_hsa051460.96640044
52RNA degradation_Homo sapiens_hsa030180.96388933
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96199094
54Pathways in cancer_Homo sapiens_hsa052000.95941576
55Steroid biosynthesis_Homo sapiens_hsa001000.95817002
56Tight junction_Homo sapiens_hsa045300.95175450
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93488255
58Axon guidance_Homo sapiens_hsa043600.93274661
59HIF-1 signaling pathway_Homo sapiens_hsa040660.92737118
60Acute myeloid leukemia_Homo sapiens_hsa052210.90742526
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90480963
62Arginine and proline metabolism_Homo sapiens_hsa003300.89790768
63TGF-beta signaling pathway_Homo sapiens_hsa043500.87353648
64DNA replication_Homo sapiens_hsa030300.85810248
65ErbB signaling pathway_Homo sapiens_hsa040120.85767180
66Wnt signaling pathway_Homo sapiens_hsa043100.84769779
67Ribosome_Homo sapiens_hsa030100.84651217
68Inositol phosphate metabolism_Homo sapiens_hsa005620.84268084
69Pentose phosphate pathway_Homo sapiens_hsa000300.84228255
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.82076498
71Notch signaling pathway_Homo sapiens_hsa043300.80356115
72Herpes simplex infection_Homo sapiens_hsa051680.80216393
73Small cell lung cancer_Homo sapiens_hsa052220.79856843
74Mismatch repair_Homo sapiens_hsa034300.79666047
75Non-small cell lung cancer_Homo sapiens_hsa052230.79475387
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77677505
77Phototransduction_Homo sapiens_hsa047440.77315111
78Proteoglycans in cancer_Homo sapiens_hsa052050.77196831
79Choline metabolism in cancer_Homo sapiens_hsa052310.76998292
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76843870
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76768460
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.76116411
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.75395633
84Sulfur relay system_Homo sapiens_hsa041220.72918680
85Synaptic vesicle cycle_Homo sapiens_hsa047210.72462629
86Thyroid hormone synthesis_Homo sapiens_hsa049180.72341279
87VEGF signaling pathway_Homo sapiens_hsa043700.72101153
88Homologous recombination_Homo sapiens_hsa034400.71801972
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71496456
90Ovarian steroidogenesis_Homo sapiens_hsa049130.70679022
91Endocytosis_Homo sapiens_hsa041440.68549614
92Carbon metabolism_Homo sapiens_hsa012000.68286110
93Rap1 signaling pathway_Homo sapiens_hsa040150.65428758
94Hepatitis C_Homo sapiens_hsa051600.65158452
95Dorso-ventral axis formation_Homo sapiens_hsa043200.64462518
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64376518
97Pancreatic cancer_Homo sapiens_hsa052120.62827693
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59225010
99Base excision repair_Homo sapiens_hsa034100.58417288
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57964956
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57376741
102HTLV-I infection_Homo sapiens_hsa051660.54160326
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53803023
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.53730159
105Oocyte meiosis_Homo sapiens_hsa041140.52277331
106Ras signaling pathway_Homo sapiens_hsa040140.49170526
107Endometrial cancer_Homo sapiens_hsa052130.47886256
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.47572344
109GnRH signaling pathway_Homo sapiens_hsa049120.46804311
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45637643
111Apoptosis_Homo sapiens_hsa042100.44918331
112ABC transporters_Homo sapiens_hsa020100.44897783
113ECM-receptor interaction_Homo sapiens_hsa045120.44549933
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.44424935
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44337601
116Regulation of autophagy_Homo sapiens_hsa041400.44293440
117Prolactin signaling pathway_Homo sapiens_hsa049170.43342284
118Pyruvate metabolism_Homo sapiens_hsa006200.42953828
119Prostate cancer_Homo sapiens_hsa052150.42154295
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41619286
121Mineral absorption_Homo sapiens_hsa049780.40679541
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.39879381
123Colorectal cancer_Homo sapiens_hsa052100.39688511
124AMPK signaling pathway_Homo sapiens_hsa041520.38998224
125One carbon pool by folate_Homo sapiens_hsa006700.38382406
126Viral carcinogenesis_Homo sapiens_hsa052030.38059726
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35505211
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.35478665
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34916486
130Melanoma_Homo sapiens_hsa052180.34479113
131Melanogenesis_Homo sapiens_hsa049160.34344829
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33464728
133Other glycan degradation_Homo sapiens_hsa005110.33224809
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32794858
135Pyrimidine metabolism_Homo sapiens_hsa002400.31922607
136Sphingolipid metabolism_Homo sapiens_hsa006000.31531671
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.27576169
138Nucleotide excision repair_Homo sapiens_hsa034200.27481547
139Protein digestion and absorption_Homo sapiens_hsa049740.27459545

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