SP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.89526254
2central nervous system myelination (GO:0022010)8.89526254
3synapsis (GO:0007129)8.57173435
4gonadal mesoderm development (GO:0007506)7.69243462
5response to parathyroid hormone (GO:0071107)7.19693244
6piRNA metabolic process (GO:0034587)6.99000386
7meiotic chromosome segregation (GO:0045132)6.41843172
8regulation of protein polyubiquitination (GO:1902914)6.23115549
9positive regulation of meiotic cell cycle (GO:0051446)6.22028535
10trivalent inorganic anion homeostasis (GO:0072506)6.13581157
11phosphate ion homeostasis (GO:0055062)6.13581157
12fatty acid elongation (GO:0030497)6.01736413
13regulation of meiosis I (GO:0060631)5.90400281
14positive regulation of meiosis (GO:0045836)5.88965160
15chromosome organization involved in meiosis (GO:0070192)5.71013669
16keratan sulfate catabolic process (GO:0042340)5.45969778
17axon ensheathment (GO:0008366)5.39683617
18ensheathment of neurons (GO:0007272)5.39683617
19myelination (GO:0042552)5.31968242
20male meiosis I (GO:0007141)5.14815966
21protein heterotrimerization (GO:0070208)5.02204949
22acrosome assembly (GO:0001675)4.91340431
23bone trabecula formation (GO:0060346)4.81640115
24mitochondrial genome maintenance (GO:0000002)4.81639874
25male meiosis (GO:0007140)4.76354061
26asymmetric protein localization (GO:0008105)4.72510798
27apical protein localization (GO:0045176)4.68525368
28cellular response to vitamin D (GO:0071305)4.65438441
29cholesterol biosynthetic process (GO:0006695)4.63799063
30DNA methylation involved in gamete generation (GO:0043046)4.63675275
31regulation of meiotic cell cycle (GO:0051445)4.56266194
32synaptonemal complex assembly (GO:0007130)4.54781934
33lateral sprouting from an epithelium (GO:0060601)4.54417890
34tooth mineralization (GO:0034505)4.53401507
35DNA synthesis involved in DNA repair (GO:0000731)4.52364605
36long-chain fatty acid biosynthetic process (GO:0042759)4.47585101
37chondrocyte development (GO:0002063)4.46727538
38spermatid development (GO:0007286)4.46381923
39mitotic sister chromatid cohesion (GO:0007064)4.42975093
40regulation of meiosis (GO:0040020)4.33310975
41myelin maintenance (GO:0043217)4.31516769
42melanocyte differentiation (GO:0030318)4.30569788
43synaptonemal complex organization (GO:0070193)4.25329916
44negative regulation of cell aging (GO:0090344)4.25023019
45biomineral tissue development (GO:0031214)4.21820474
46detection of light stimulus involved in visual perception (GO:0050908)4.19205339
47detection of light stimulus involved in sensory perception (GO:0050962)4.19205339
48establishment of mitochondrion localization (GO:0051654)4.15371231
49sterol biosynthetic process (GO:0016126)4.12292762
50reciprocal meiotic recombination (GO:0007131)4.11773286
51reciprocal DNA recombination (GO:0035825)4.11773286
52cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.10900974
53negative regulation of gene silencing (GO:0060969)4.09813641
54meiotic nuclear division (GO:0007126)4.06499686
55mitotic cell cycle arrest (GO:0071850)4.03295818
56regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.96291976
57limb bud formation (GO:0060174)3.95426437
58negative regulation of neurotransmitter secretion (GO:0046929)3.87778528
59lymphangiogenesis (GO:0001946)3.85339623
60negative regulation of neurotransmitter transport (GO:0051589)3.85176429
61meiosis I (GO:0007127)3.85069298
62pigment cell differentiation (GO:0050931)3.83217806
63protein localization to endosome (GO:0036010)3.82751262
64response to methylmercury (GO:0051597)3.81149254
65response to gravity (GO:0009629)3.80931426
66proline biosynthetic process (GO:0006561)3.76248022
67regulation of collateral sprouting (GO:0048670)3.75801401
68TOR signaling (GO:0031929)3.75324465
69skin morphogenesis (GO:0043589)3.70865013
70collagen fibril organization (GO:0030199)3.63893370
71meiotic cell cycle process (GO:1903046)3.62734811
72regulation of megakaryocyte differentiation (GO:0045652)3.60915239
73keratan sulfate biosynthetic process (GO:0018146)3.58621190
74cellular response to vitamin (GO:0071295)3.56640907
75replacement ossification (GO:0036075)3.55339377
76endochondral ossification (GO:0001958)3.55339377
77negative regulation of bone mineralization (GO:0030502)3.52036990
78sphingomyelin metabolic process (GO:0006684)3.45341175
79entrainment of circadian clock (GO:0009649)3.44878433
80cellular response to ATP (GO:0071318)3.43904189
81astrocyte development (GO:0014002)3.43379152
82response to phenylpropanoid (GO:0080184)3.38834555
83membrane tubulation (GO:0097320)3.37955356
84sulfate transmembrane transport (GO:1902358)3.32686995
85positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.29684237
86germ cell development (GO:0007281)3.27610458
87cartilage condensation (GO:0001502)3.25518533
88cell aggregation (GO:0098743)3.25518533
89long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.21467209
90negative regulation of keratinocyte proliferation (GO:0010839)3.19636593
91import into cell (GO:0098657)3.17572285
92protein K6-linked ubiquitination (GO:0085020)3.16881307
93positive regulation of oligodendrocyte differentiation (GO:0048714)3.16144873
94positive regulation of megakaryocyte differentiation (GO:0045654)3.14935261
95DNA replication-dependent nucleosome assembly (GO:0006335)3.13616371
96DNA replication-dependent nucleosome organization (GO:0034723)3.13616371
97fusion of sperm to egg plasma membrane (GO:0007342)3.13438780
98cholesterol catabolic process (GO:0006707)3.11354267
99sterol catabolic process (GO:0016127)3.11354267
100mitotic nuclear envelope reassembly (GO:0007084)3.11185696
101nuclear envelope reassembly (GO:0031468)3.11185696
102amyloid precursor protein metabolic process (GO:0042982)3.10342647
103collagen catabolic process (GO:0030574)3.09339047
104regulation of synapse maturation (GO:0090128)3.08989909
105convergent extension (GO:0060026)3.08487268
106virion attachment to host cell (GO:0019062)3.06778461
107adhesion of symbiont to host cell (GO:0044650)3.06778461
108regulation of G0 to G1 transition (GO:0070316)3.06383324
109negative regulation of inclusion body assembly (GO:0090084)3.05624966
110negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.05414682
111negative regulation of biomineral tissue development (GO:0070168)3.04838064
112negative regulation of JUN kinase activity (GO:0043508)3.04406120
113GDP-mannose metabolic process (GO:0019673)3.03007727
114fatty-acyl-CoA biosynthetic process (GO:0046949)3.02930656
115regulation of gene silencing (GO:0060968)3.02802693
116membrane raft organization (GO:0031579)3.02284855
117extracellular matrix assembly (GO:0085029)3.02252757
118sulfate transport (GO:0008272)3.02091087
119autophagic vacuole fusion (GO:0000046)3.00214294
120long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.00053469
121base-excision repair, AP site formation (GO:0006285)2.99596928
122axon development (GO:0061564)2.98674870
123chondrocyte proliferation (GO:0035988)2.97139738
124organelle membrane fusion (GO:0090174)2.96863700
125isoprenoid biosynthetic process (GO:0008299)2.96610457
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.95290010
127negative regulation of focal adhesion assembly (GO:0051895)2.95153363
128negative regulation of cell junction assembly (GO:1901889)2.95153363
129negative regulation of adherens junction organization (GO:1903392)2.95153363
130creatine metabolic process (GO:0006600)2.93407245
131resolution of meiotic recombination intermediates (GO:0000712)2.93305755
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93280532
133oligodendrocyte differentiation (GO:0048709)2.93074287
134collagen metabolic process (GO:0032963)2.92430952
135oocyte maturation (GO:0001556)2.92145155
136sister chromatid cohesion (GO:0007062)2.91481220
137negative regulation of meiosis (GO:0045835)2.91295001
138glycerophospholipid catabolic process (GO:0046475)2.90671551
139neuroepithelial cell differentiation (GO:0060563)2.90074929
140cranial suture morphogenesis (GO:0060363)2.89970085
141phosphate ion transmembrane transport (GO:0035435)2.87338546
142snRNA transcription (GO:0009301)2.86875345
143regulation of lipoprotein metabolic process (GO:0050746)2.86503486
144proline metabolic process (GO:0006560)2.86039054
145negative regulation of protein localization to cell surface (GO:2000009)2.85655945
146bone morphogenesis (GO:0060349)2.85396396
147photoreceptor cell differentiation (GO:0046530)2.84464369
148eye photoreceptor cell differentiation (GO:0001754)2.84464369
149entrainment of circadian clock by photoperiod (GO:0043153)2.83036431
150bone mineralization (GO:0030282)2.82477170
151multicellular organismal catabolic process (GO:0044243)2.81710236
152cilium or flagellum-dependent cell motility (GO:0001539)2.81462761
153regulation of phospholipid biosynthetic process (GO:0071071)2.81260633
154positive regulation of epidermal cell differentiation (GO:0045606)2.78969040
155branching involved in labyrinthine layer morphogenesis (GO:0060670)2.78460884
156regulation of cilium movement (GO:0003352)2.77800732
157spermatogenesis (GO:0007283)2.77481128
158regulation of cholesterol homeostasis (GO:2000188)2.77389702
159positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.77373076
160male gamete generation (GO:0048232)2.77191542
161positive regulation of osteoblast proliferation (GO:0033690)2.77155659
162establishment of apical/basal cell polarity (GO:0035089)2.76723716
163negative regulation of epithelial to mesenchymal transition (GO:0010719)2.75164058
164camera-type eye morphogenesis (GO:0048593)2.74556422
165hypotonic response (GO:0006971)2.74497922
166keratan sulfate metabolic process (GO:0042339)2.73981086
167multicellular organismal macromolecule metabolic process (GO:0044259)2.72548797
168glial cell migration (GO:0008347)2.71798941
169gene silencing by RNA (GO:0031047)2.71548974
170tRNA methylation (GO:0030488)2.70876274
171positive regulation of extracellular matrix organization (GO:1903055)2.69770837
172protein neddylation (GO:0045116)2.69201612
173decidualization (GO:0046697)2.68648573
174fatty-acyl-CoA metabolic process (GO:0035337)2.68507170
175sperm motility (GO:0030317)2.67593548
176positive regulation of catenin import into nucleus (GO:0035413)2.66934342
177negative regulation of meiotic cell cycle (GO:0051447)2.66685380
178embryonic body morphogenesis (GO:0010172)2.65713736
179peripheral nervous system axon ensheathment (GO:0032292)2.65665477
180myelination in peripheral nervous system (GO:0022011)2.65665477
181mammary gland epithelial cell proliferation (GO:0033598)2.64886767
182craniofacial suture morphogenesis (GO:0097094)2.64706565
183phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.64453548
184folic acid transport (GO:0015884)2.64434783
185response to lipoprotein particle (GO:0055094)2.64148772
186positive regulation of heat generation (GO:0031652)2.62418090
187response to vitamin D (GO:0033280)2.60560169
188presynaptic membrane organization (GO:0097090)2.58820991
189short-term memory (GO:0007614)2.57660626
190enteric nervous system development (GO:0048484)2.57350314
191negative regulation of chondrocyte differentiation (GO:0032331)2.56471856
192response to redox state (GO:0051775)2.55243085
193negative regulation of catenin import into nucleus (GO:0035414)2.54462311
194osteoblast development (GO:0002076)2.53953422
195multicellular organismal metabolic process (GO:0044236)2.53752653
196anterior/posterior axis specification, embryo (GO:0008595)2.49817092
197mesenchymal cell proliferation (GO:0010463)2.49471839
198organ growth (GO:0035265)2.48529513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.47838661
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.02222122
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88141614
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.63942084
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.53091547
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38164923
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.23174154
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.19143266
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.10651123
10TP63_19390658_ChIP-ChIP_HaCaT_Human3.09216660
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76201289
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70225644
13IGF1R_20145208_ChIP-Seq_DFB_Human2.69985695
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.64831209
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54127191
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.29618264
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18351765
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09215685
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.05575167
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05356965
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04188349
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.00083642
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99888642
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99844190
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99844190
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99760430
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93611111
28* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92767794
29* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92767794
30* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92767794
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.90413031
32GBX2_23144817_ChIP-Seq_PC3_Human1.89886880
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.89003980
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88710480
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.87838860
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81070949
37CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.80157373
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77827670
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75509398
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.75357096
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75219440
42* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72639443
43STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.72302482
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71619661
45* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70825835
46ZNF274_21170338_ChIP-Seq_K562_Hela1.70056919
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.69656455
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66682723
49* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63004073
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.61768325
51AR_21572438_ChIP-Seq_LNCaP_Human1.59948284
52* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59906840
53TP53_22573176_ChIP-Seq_HFKS_Human1.58783532
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52962414
55RNF2_27304074_Chip-Seq_NSC_Mouse1.52356817
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52058921
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48160826
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47150701
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43851385
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43579589
61ERA_21632823_ChIP-Seq_H3396_Human1.43547351
62VDR_21846776_ChIP-Seq_THP-1_Human1.42175488
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40728837
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.39444648
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38713084
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38425268
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.37712079
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37521030
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.36412243
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31457240
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31229301
72* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30769805
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30516298
74MYC_19829295_ChIP-Seq_ESCs_Human1.30472706
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29851499
76* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29781958
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.27719291
78PHF8_20622854_ChIP-Seq_HELA_Human1.27601628
79DROSHA_22980978_ChIP-Seq_HELA_Human1.27457432
80P68_20966046_ChIP-Seq_HELA_Human1.26972998
81* E2F1_20622854_ChIP-Seq_HELA_Human1.26376286
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23875595
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23065397
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.21781905
85HOXB7_26014856_ChIP-Seq_BT474_Human1.21763206
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20348931
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.20286321
88XRN2_22483619_ChIP-Seq_HELA_Human1.18810633
89* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17970467
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.16801100
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14974777
92BCL6_27268052_Chip-Seq_Bcells_Human1.14844011
93SMC4_20622854_ChIP-Seq_HELA_Human1.14385849
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14382713
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14382713
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13550730
97* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12804978
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12577983
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12499551
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.11610840
101* RARB_24833708_ChIP-Seq_LIVER_Mouse1.11208767
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.09358664
103BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.08945321
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08732921
105OCT4_19829295_ChIP-Seq_ESCs_Human1.08702715
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07604825
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07263738
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.06126219
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05770035
110CJUN_26792858_Chip-Seq_BT549_Human1.03457535
111ERG_20517297_ChIP-Seq_VCAP_Human1.03433413
112KDM2B_26808549_Chip-Seq_K562_Human1.02268792
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01457468
114EOMES_21245162_ChIP-Seq_HESCs_Human1.01025542
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98960604
116FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98700034
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98309972
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98275666
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98097897
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97875935
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97363291
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97332855
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.97174564
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97174564
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96926874
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96483934
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96405698
128POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96283344
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96264287
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96149377
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.96020966
132VDR_22108803_ChIP-Seq_LS180_Human0.95447411
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.94216808
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93867382
135CTCF_27219007_Chip-Seq_Bcells_Human0.93849123
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.93142641
137RAC3_21632823_ChIP-Seq_H3396_Human0.93082104
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92696252
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91424118
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.91091182
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90830231
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89687616
143P53_21459846_ChIP-Seq_SAOS-2_Human0.89450615
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89354032
145AHR_22903824_ChIP-Seq_MCF-7_Human0.89310146
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89056108
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.88496582
148* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88123282
149* FOXP1_21924763_ChIP-Seq_HESCs_Human0.87948803
150P300_19829295_ChIP-Seq_ESCs_Human0.87643200
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87558100
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87152344
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86968933
154CBP_20019798_ChIP-Seq_JUKART_Human0.86968933
155TBL1_22424771_ChIP-Seq_293T_Human0.86577103
156PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86363752
157VDR_23849224_ChIP-Seq_CD4+_Human0.86108779
158POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86046852
159EZH2_22144423_ChIP-Seq_EOC_Human0.85631277
160ER_23166858_ChIP-Seq_MCF-7_Human0.85539221
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85435052
162TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85409105
163TAF2_19829295_ChIP-Seq_ESCs_Human0.84755226
164ISL1_27105846_Chip-Seq_CPCs_Mouse0.84575468
165CTCF_21964334_Chip-Seq_Bcells_Human0.84424503
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84324207
167SOX2_21211035_ChIP-Seq_LN229_Human0.84268952
168CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83941627
169EWS_26573619_Chip-Seq_HEK293_Human0.83740307
170E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83242944
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.82782574
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82442473
173LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82331620
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82256611
175* CTCF_20526341_ChIP-Seq_ESCs_Human0.81738013
176KLF5_25053715_ChIP-Seq_YYC3_Human0.81379608
177SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80291849
178FUS_26573619_Chip-Seq_HEK293_Human0.80195048
179EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80173249
180SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80145616
181HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79871407
182YY1_22570637_ChIP-Seq_MALME-3M_Human0.79782501
183STAT3_23295773_ChIP-Seq_U87_Human0.79217274
184FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78631368
185ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78454273
186CIITA_25753668_ChIP-Seq_RAJI_Human0.78433483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH7.44408941
2MP0001542_abnormal_bone_strength4.92583778
3MP0008438_abnormal_cutaneous_collagen4.45330120
4MP0004185_abnormal_adipocyte_glucose3.92925304
5MP0005503_abnormal_tendon_morphology3.54007245
6MP0000920_abnormal_myelination3.32478357
7MP0001502_abnormal_circadian_rhythm3.25413021
8MP0004134_abnormal_chest_morphology3.19541862
9MP0005171_absent_coat_pigmentation2.77927438
10MP0005174_abnormal_tail_pigmentation2.74776356
11MP0010030_abnormal_orbit_morphology2.73135708
12MP0005076_abnormal_cell_differentiation2.65176846
13MP0001986_abnormal_taste_sensitivity2.54961966
14MP0000462_abnormal_digestive_system2.54657244
15MP0008877_abnormal_DNA_methylation2.46187587
16* MP0009250_abnormal_appendicular_skeleto2.28043247
17MP0002210_abnormal_sex_determination2.23253080
18MP0005275_abnormal_skin_tensile2.22893889
19MP0001299_abnormal_eye_distance/2.20814631
20* MP0002896_abnormal_bone_mineralization2.19273995
21MP0002736_abnormal_nociception_after2.18213746
22MP0000762_abnormal_tongue_morphology2.12770538
23MP0003950_abnormal_plasma_membrane2.06288351
24MP0003693_abnormal_embryo_hatching2.05846487
25MP0005083_abnormal_biliary_tract1.99753353
26MP0002998_abnormal_bone_remodeling1.99590117
27MP0001929_abnormal_gametogenesis1.97328753
28MP0005508_abnormal_skeleton_morphology1.94701916
29MP0002282_abnormal_trachea_morphology1.93632039
30MP0002108_abnormal_muscle_morphology1.92991393
31MP0001968_abnormal_touch/_nociception1.87061141
32MP0000163_abnormal_cartilage_morphology1.86509798
33MP0002115_abnormal_skeleton_extremities1.86402261
34MP0003718_maternal_effect1.81081253
35MP0001661_extended_life_span1.79272482
36MP0010307_abnormal_tumor_latency1.78438596
37MP0002160_abnormal_reproductive_system1.78083261
38MP0003283_abnormal_digestive_organ1.73739736
39MP0005623_abnormal_meninges_morphology1.69889177
40MP0003385_abnormal_body_wall1.66424727
41MP0002295_abnormal_pulmonary_circulatio1.66408926
42MP0004272_abnormal_basement_membrane1.66175722
43MP0001145_abnormal_male_reproductive1.65965984
44MP0003698_abnormal_male_reproductive1.62412915
45MP0000653_abnormal_sex_gland1.54452536
46MP0000371_diluted_coat_color1.53736725
47MP0005409_darkened_coat_color1.52012827
48MP0001346_abnormal_lacrimal_gland1.51409585
49MP0003755_abnormal_palate_morphology1.48746017
50MP0004885_abnormal_endolymph1.45645745
51MP0004019_abnormal_vitamin_homeostasis1.43314008
52MP0000751_myopathy1.42313017
53MP0002249_abnormal_larynx_morphology1.41810109
54MP0001664_abnormal_digestion1.41234892
55MP0003634_abnormal_glial_cell1.39095234
56MP0000432_abnormal_head_morphology1.39090761
57MP0009278_abnormal_bone_marrow1.38659018
58MP0003937_abnormal_limbs/digits/tail_de1.38311674
59MP0002116_abnormal_craniofacial_bone1.37852276
60MP0002933_joint_inflammation1.37817290
61MP0000566_synostosis1.37442207
62MP0000015_abnormal_ear_pigmentation1.37028612
63MP0003329_amyloid_beta_deposits1.35642165
64MP0001340_abnormal_eyelid_morphology1.34687992
65MP0008260_abnormal_autophagy1.33874868
66MP0003935_abnormal_craniofacial_develop1.31894169
67MP0002113_abnormal_skeleton_development1.30524826
68MP0002932_abnormal_joint_morphology1.29694286
69MP0010368_abnormal_lymphatic_system1.29580557
70MP0000778_abnormal_nervous_system1.28998423
71MP0003690_abnormal_glial_cell1.26510710
72MP0005423_abnormal_somatic_nervous1.25866218
73MP0003077_abnormal_cell_cycle1.25284285
74MP0003646_muscle_fatigue1.24008163
75MP0005551_abnormal_eye_electrophysiolog1.23255823
76MP0008057_abnormal_DNA_replication1.23030687
77MP0005666_abnormal_adipose_tissue1.23024243
78MP0003959_abnormal_lean_body1.21924432
79* MP0002109_abnormal_limb_morphology1.21840267
80MP0003111_abnormal_nucleus_morphology1.21642797
81MP0000049_abnormal_middle_ear1.16531247
82MP0005375_adipose_tissue_phenotype1.16490484
83MP0000427_abnormal_hair_cycle1.16451001
84MP0005390_skeleton_phenotype1.15736609
85MP0001485_abnormal_pinna_reflex1.13198361
86MP0004142_abnormal_muscle_tone1.10613827
87MP0004133_heterotaxia1.09848021
88MP0002233_abnormal_nose_morphology1.09478151
89MP0001348_abnormal_lacrimal_gland1.07993502
90MP0004742_abnormal_vestibular_system1.07962496
91MP0009115_abnormal_fat_cell1.07837594
92MP0004270_analgesia1.07014174
93MP0004859_abnormal_synaptic_plasticity1.06782614
94MP0003279_aneurysm1.06636801
95MP0002111_abnormal_tail_morphology1.05028620
96MP0000579_abnormal_nail_morphology1.04504799
97MP0002089_abnormal_postnatal_growth/wei1.04391727
98MP0005257_abnormal_intraocular_pressure1.03922789
99MP0003795_abnormal_bone_structure1.02746198
100MP0002060_abnormal_skin_morphology1.00558475
101MP0006072_abnormal_retinal_apoptosis0.99659103
102MP0002009_preneoplasia0.98802505
103* MP0002114_abnormal_axial_skeleton0.98386717
104MP0004147_increased_porphyrin_level0.95185507
105MP0001905_abnormal_dopamine_level0.95080095
106MP0002064_seizures0.94779386
107MP0002161_abnormal_fertility/fecundity0.94464699
108MP0002272_abnormal_nervous_system0.94296390
109MP0009780_abnormal_chondrocyte_physiolo0.93339286
110MP0000955_abnormal_spinal_cord0.91769263
111MP0001243_abnormal_dermal_layer0.91685350
112MP0000538_abnormal_urinary_bladder0.89731097
113MP0005389_reproductive_system_phenotype0.89148674
114MP0000428_abnormal_craniofacial_morphol0.88962430
115MP0002075_abnormal_coat/hair_pigmentati0.88846789
116MP0000003_abnormal_adipose_tissue0.88714691
117MP0003938_abnormal_ear_development0.88124602
118MP0006054_spinal_hemorrhage0.87783251
119MP0004233_abnormal_muscle_weight0.86808907
120MP0010678_abnormal_skin_adnexa0.86793150
121MP0003942_abnormal_urinary_system0.86296087
122MP0000647_abnormal_sebaceous_gland0.85915981
123MP0004145_abnormal_muscle_electrophysio0.84053334
124MP0003633_abnormal_nervous_system0.83946443
125MP0001293_anophthalmia0.83508322
126MP0000013_abnormal_adipose_tissue0.83314128
127MP0003880_abnormal_central_pattern0.83005068
128MP0002735_abnormal_chemical_nociception0.81850750
129MP0000767_abnormal_smooth_muscle0.81428961
130MP0008875_abnormal_xenobiotic_pharmacok0.80398727
131MP0001963_abnormal_hearing_physiology0.80284405
132MP0003136_yellow_coat_color0.79265231
133MP0000747_muscle_weakness0.78081106
134MP0003943_abnormal_hepatobiliary_system0.77840122
135MP0000627_abnormal_mammary_gland0.77703756
136MP0001533_abnormal_skeleton_physiology0.77632053
137MP0003631_nervous_system_phenotype0.77090954
138MP0001879_abnormal_lymphatic_vessel0.76855662
139MP0003137_abnormal_impulse_conducting0.76430406
140MP0003632_abnormal_nervous_system0.74961373
141MP0001486_abnormal_startle_reflex0.74032998
142MP0003195_calcinosis0.73990014
143MP0001958_emphysema0.73671109
144MP0002095_abnormal_skin_pigmentation0.73610133
145MP0000733_abnormal_muscle_development0.72658432
146MP0003936_abnormal_reproductive_system0.71537982
147MP0001119_abnormal_female_reproductive0.71152159
148MP0000470_abnormal_stomach_morphology0.71101118
149MP0005410_abnormal_fertilization0.70784606
150MP0009046_muscle_twitch0.70778036
151MP0008058_abnormal_DNA_repair0.68251034
152MP0000358_abnormal_cell_content/0.66454132
153MP0003699_abnormal_female_reproductive0.64479992
154MP0010386_abnormal_urinary_bladder0.63838383
155MP0003183_abnormal_peptide_metabolism0.63351461
156MP0000569_abnormal_digit_pigmentation0.62725477
157MP0010094_abnormal_chromosome_stability0.60427068
158MP0000383_abnormal_hair_follicle0.60414988
159MP0001188_hyperpigmentation0.58836911
160MP0005332_abnormal_amino_acid0.58380953
161MP0002928_abnormal_bile_duct0.58023371
162MP0001324_abnormal_eye_pigmentation0.57620157
163MP0005365_abnormal_bile_salt0.56857032
164MP0005330_cardiomyopathy0.56255623
165MP0003453_abnormal_keratinocyte_physiol0.56194225
166MP0001666_abnormal_nutrient_absorption0.54302908
167MP0004957_abnormal_blastocyst_morpholog0.53150017
168MP0001984_abnormal_olfaction0.51438449
169MP0001186_pigmentation_phenotype0.51232319
170MP0001944_abnormal_pancreas_morphology0.50755295

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.33409205
2Facial diplegia (HP:0001349)5.66550202
3Enlarged epiphyses (HP:0010580)5.35357078
4Premature rupture of membranes (HP:0001788)5.27003500
5Ulnar bowing (HP:0003031)4.90857119
6Metaphyseal cupping (HP:0003021)4.77122794
7Protrusio acetabuli (HP:0003179)4.62377109
8Increased density of long bones (HP:0006392)4.59288715
9Abnormality of calcium-phosphate metabolism (HP:0100530)4.41140029
10Coronal craniosynostosis (HP:0004440)4.25380524
11Small epiphyses (HP:0010585)4.20249806
12Metaphyseal irregularity (HP:0003025)4.17323178
13Hypoplastic ischia (HP:0003175)3.98958832
14Overgrowth (HP:0001548)3.84871473
15Epiphyseal dysplasia (HP:0002656)3.83495574
16Generalized hypopigmentation of hair (HP:0011358)3.77389050
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.73839324
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.73839324
19Abnormality of the phalanges of the 2nd finger (HP:0009541)3.62538007
20Abnormality of the ischium (HP:0003174)3.62048203
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.45729874
22Abnormality of dentin (HP:0010299)3.40179969
23Neonatal short-limb short stature (HP:0008921)3.37583451
24Cupped ribs (HP:0000887)3.31317090
25Neurofibrillary tangles (HP:0002185)3.28752520
26Carpal bone hypoplasia (HP:0001498)3.25228335
27Broad ribs (HP:0000885)3.23838239
28Craniofacial hyperostosis (HP:0004493)3.18806041
29Anteriorly placed anus (HP:0001545)3.15076405
30Turricephaly (HP:0000262)3.14668673
31Hypophosphatemic rickets (HP:0004912)3.06463763
32Hypophosphatemia (HP:0002148)3.05601311
33Mild short stature (HP:0003502)3.04444337
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.03209426
35Rib fusion (HP:0000902)3.00453122
36Hypoplasia of the fovea (HP:0007750)2.99823832
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.99823832
38Atrophic scars (HP:0001075)2.97817440
39Abnormal albumin level (HP:0012116)2.97587133
40Hypoalbuminemia (HP:0003073)2.97587133
41Hypoplastic pelvis (HP:0008839)2.96406833
42Vertebral arch anomaly (HP:0008438)2.95308295
43Alacrima (HP:0000522)2.93584817
44Vertebral clefting (HP:0008428)2.91688477
45Irregular epiphyses (HP:0010582)2.88564374
46Abnormality of the fovea (HP:0000493)2.87731641
47Anterior segment dysgenesis (HP:0007700)2.81994961
48Osteoarthritis (HP:0002758)2.79575569
49Premature skin wrinkling (HP:0100678)2.77892532
50Biconcave vertebral bodies (HP:0004586)2.77837564
51Femoral bowing (HP:0002980)2.74978312
52Bowing of the arm (HP:0006488)2.74191991
53Bowed forearm bones (HP:0003956)2.74191991
54Thin bony cortex (HP:0002753)2.72683382
55Infantile muscular hypotonia (HP:0008947)2.70627029
56Peritonitis (HP:0002586)2.69243110
57* Wormian bones (HP:0002645)2.69229739
58Abnormality of the vertebral endplates (HP:0005106)2.67995749
59Amelogenesis imperfecta (HP:0000705)2.64471853
60Abnormality of the costochondral junction (HP:0000919)2.64145084
61Cranial hyperostosis (HP:0004437)2.61250117
62Abnormality of the 2nd finger (HP:0004100)2.60795882
63Vitreoretinal degeneration (HP:0000655)2.58994378
64Abnormal vertebral ossification (HP:0100569)2.57340825
65Spondylolisthesis (HP:0003302)2.57319620
66Metaphyseal dysplasia (HP:0100255)2.55178785
67Abnormality of the middle phalanges of the toes (HP:0010183)2.51208943
68Soft skin (HP:0000977)2.50052803
69Abnormality of the corticospinal tract (HP:0002492)2.47419024
70Irregular vertebral endplates (HP:0003301)2.46227767
71Concave nail (HP:0001598)2.44406578
72Cerebral inclusion bodies (HP:0100314)2.44315909
73Delayed epiphyseal ossification (HP:0002663)2.39469625
74Stridor (HP:0010307)2.38977674
75Choanal stenosis (HP:0000452)2.38659287
76Abnormality of the renal cortex (HP:0011035)2.38639182
77Blue sclerae (HP:0000592)2.34038440
78Flattened epiphyses (HP:0003071)2.32568874
79Abnormality of small intestinal villus morphology (HP:0011472)2.32540043
80Villous atrophy (HP:0011473)2.32540043
81Oligodactyly (hands) (HP:0001180)2.30783295
82Tibial bowing (HP:0002982)2.27380735
83Bell-shaped thorax (HP:0001591)2.26464368
84Platyspondyly (HP:0000926)2.24044730
85Flat capital femoral epiphysis (HP:0003370)2.23962681
86Bladder diverticulum (HP:0000015)2.22787899
87Progressive external ophthalmoplegia (HP:0000590)2.22241256
88Abnormality of the epiphysis of the femoral head (HP:0010574)2.22226320
89Thickened helices (HP:0000391)2.22219700
90Coxa vara (HP:0002812)2.21353846
91Decreased lacrimation (HP:0000633)2.20313311
92Broad metatarsal (HP:0001783)2.15984156
93Shallow orbits (HP:0000586)2.12786304
94Hyperextensible skin (HP:0000974)2.11182841
95Elevated alkaline phosphatase (HP:0003155)2.11041136
96Volvulus (HP:0002580)2.10173668
97Spinal cord compression (HP:0002176)2.10037276
98Follicular hyperkeratosis (HP:0007502)2.09224603
99Decreased skull ossification (HP:0004331)2.08259046
100Parakeratosis (HP:0001036)2.08107551
101Thrombocytosis (HP:0001894)2.08090972
102Genu varum (HP:0002970)2.06219076
103Ectopic kidney (HP:0000086)2.05915115
104Aortic dissection (HP:0002647)2.05093300
105Aplasia involving bones of the upper limbs (HP:0009823)2.03658693
106Aplasia of the phalanges of the hand (HP:0009802)2.03658693
107Aplasia involving bones of the extremities (HP:0009825)2.03658693
108Congenital stationary night blindness (HP:0007642)2.03636002
109Papilledema (HP:0001085)10.2332171
110Ocular albinism (HP:0001107)1.99658708
111Abnormal tarsal ossification (HP:0008369)1.98487316
112Abnormality of skull ossification (HP:0002703)1.97604014
113Esotropia (HP:0000565)1.97550165
114Annular pancreas (HP:0001734)1.97299497
115Attenuation of retinal blood vessels (HP:0007843)1.97281989
116Abnormality of the femoral head (HP:0003368)1.96616596
117Relative macrocephaly (HP:0004482)1.96517641
118Rickets (HP:0002748)1.96504376
119Insidious onset (HP:0003587)1.96108926
120Termporal pattern (HP:0011008)1.96108926
121Abnormal urine phosphate concentration (HP:0012599)1.95997266
122Onion bulb formation (HP:0003383)1.95847145
123Abnormality of femoral epiphyses (HP:0006499)1.93866217
124Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93866217
125Proximal amyotrophy (HP:0007126)1.93014013
126Abnormality of alkaline phosphatase activity (HP:0004379)1.89923218
127Woolly hair (HP:0002224)1.89528252
128Peripheral hypomyelination (HP:0007182)1.87528909
129Chronic hepatic failure (HP:0100626)1.87362351
130Hip contracture (HP:0003273)1.86440949
131Abnormal hair laboratory examination (HP:0003328)1.85436321
132Wide anterior fontanel (HP:0000260)1.84852861
133Mixed hearing impairment (HP:0000410)1.84409620
134Split foot (HP:0001839)1.83919331
135Abnormality of the parietal bone (HP:0002696)1.83851946
136Limited hip movement (HP:0008800)1.83635479
137Sudden death (HP:0001699)1.82986990
138Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.82948316
139Limited elbow extension (HP:0001377)1.82594832
140Flat occiput (HP:0005469)1.82127247
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82053054
142Osteomalacia (HP:0002749)1.81358039
143Diaphragmatic weakness (HP:0009113)1.81305532
144Abnormal enzyme/coenzyme activity (HP:0012379)1.79603186
145Preaxial foot polydactyly (HP:0001841)1.78156705
146Aplasia of the musculature (HP:0100854)1.77957301
147Synostosis involving the elbow (HP:0003938)1.77511769
148Humeroradial synostosis (HP:0003041)1.77511769
149Short hallux (HP:0010109)1.77187039
150Polyuria (HP:0000103)1.76614908
151Absent epiphyses (HP:0010577)1.75694369
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75694369
153Genu recurvatum (HP:0002816)1.74988658
154Sensory axonal neuropathy (HP:0003390)1.74272760
155Hyperglycinuria (HP:0003108)1.73875521
156Aplasia/Hypoplasia of the macula (HP:0008059)1.73713417
157Slender build (HP:0001533)1.73661047
158Breech presentation (HP:0001623)1.72797065
159Rectovaginal fistula (HP:0000143)1.72662018
160Rectal fistula (HP:0100590)1.72662018
161Polydipsia (HP:0001959)1.71151112
162Abnormal drinking behavior (HP:0030082)1.71151112
163Persistence of primary teeth (HP:0006335)1.69359726
164Facial hemangioma (HP:0000329)1.67930878
165Abnormality of the proximal phalanges of the hand (HP:0009834)1.65152108
166Abnormality of iron homeostasis (HP:0011031)1.64911303
167Renal cortical cysts (HP:0000803)1.63079133
168Curly hair (HP:0002212)1.61849334
169Patellar aplasia (HP:0006443)1.61814791
170Capillary hemangiomas (HP:0005306)1.59547506
171Generalized hypopigmentation (HP:0007513)1.58183348
172Broad phalanges of the hand (HP:0009768)1.56980383
173Abnormality of the labia majora (HP:0012881)1.56271738
174Abnormality of the renal medulla (HP:0100957)1.55741628
175Tubular atrophy (HP:0000092)1.55266904
176Iris hypopigmentation (HP:0007730)1.54994194
177Atresia of the external auditory canal (HP:0000413)1.54648945
178Aplasia/Hypoplasia affecting the retina (HP:0008061)1.53583804
179Constricted visual fields (HP:0001133)1.52957784
180Abnormality of the frontal sinuses (HP:0002687)1.52269945
181Lip pit (HP:0100267)1.51725636
182Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.51209576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.17515407
2ZAK6.75075435
3DDR26.28445851
4STK394.94809865
5ICK3.83099484
6EPHB13.09109065
7STK38L2.99418145
8MAPK152.86393557
9CDK122.73769895
10OXSR12.73438639
11FGR2.65252839
12UHMK12.48356821
13FGFR22.33308921
14MAPKAPK52.20344107
15MET2.17796000
16TYRO31.97832923
17VRK11.87744752
18WNK41.84820176
19BMX1.81320926
20CCNB11.80644857
21STK241.79237248
22MST41.74832934
23LIMK11.73729980
24TRPM71.70078296
25MAP3K61.64519940
26WNK11.63463961
27BCR1.61619155
28PBK1.59955955
29ACVR1B1.58438279
30CSNK1A1L1.58337227
31WEE11.52092131
32CSNK1G31.49033983
33NTRK11.46670463
34CSNK1G11.42344636
35PDK21.41920544
36TSSK61.40827637
37PDGFRA1.37696668
38PKN11.29072643
39SIK11.26339971
40ROCK21.24933051
41PRKD21.23056670
42PINK11.19694716
43CAMK2B1.18906508
44LATS11.15887594
45AKT21.09591432
46CSNK1G21.09198089
47BCKDK1.06653299
48MELK1.06168246
49CSK1.05969580
50PAK61.04161853
51FLT31.04123329
52FRK1.04035926
53RPS6KA51.03929232
54PRPF4B1.03873011
55PIM11.01232725
56KDR0.99220421
57GSK3A0.99024036
58CAMK2D0.97026200
59DAPK20.96004682
60PHKG10.95526176
61PHKG20.95526176
62DYRK1B0.88784227
63MST1R0.88177253
64CLK10.85424189
65PAK30.84784853
66TAF10.83411915
67DMPK0.81334608
68CDC42BPA0.79262668
69MARK20.78935214
70MATK0.77127086
71CAMK2A0.74938560
72DYRK20.74202105
73PRKD10.74091701
74LATS20.70111106
75PDGFRB0.69568725
76TTK0.68775098
77CHEK20.68087766
78CDK190.68023809
79CDK140.67880114
80CDK40.67650404
81EPHA30.65931425
82PIM20.64811889
83MAP3K110.62929103
84STK100.62784289
85PAK20.61149595
86AURKA0.60921416
87FGFR10.60839354
88NEK60.59753116
89CAMK2G0.59313782
90CAMK1G0.59009123
91CDK150.58006133
92PLK10.57264091
93PIK3CA0.56328355
94CDK80.55530248
95EPHA40.54136873
96MAP3K130.52715340
97CDK180.52257099
98MUSK0.51877323
99MAP3K20.51287548
100CDK11A0.50667689
101STK160.50597022
102MAP3K80.50364053
103CAMK1D0.49778150
104PRKAA10.49555300
105PRKCE0.48601901
106MKNK10.47886867
107PNCK0.45493703
108CDK50.44079586
109INSR0.43402230
110PTK20.43185036
111TESK20.42717847
112MAPK100.42525099
113PRKCI0.42157077
114STK40.41855966
115CDK60.41195195
116JAK20.39999298
117PDPK10.39898537
118BMPR1B0.38195381
119HIPK20.37726236
120YES10.37254404
121PRKD30.36673446
122CSNK1A10.36022967
123KSR20.35680749
124EGFR0.35447424
125NTRK30.35432543
126CSNK1D0.35317007
127STK380.35279773
128CDK70.34735923
129FYN0.33512864
130MTOR0.33283686
131STK30.32082757
132PLK40.32005262
133MAPK10.31733746
134MAP3K10.31721337
135PRKCQ0.31686300
136ROCK10.30792653
137CDK30.30543324
138AURKB0.30187707
139PAK10.29768347
140CAMK10.29600034
141PRKCH0.29450751
142MAPK70.28930317
143MAPK40.28618916
144CASK0.28282588
145* MAPK140.26752679
146RPS6KB10.26586229
147SGK4940.25582508
148SGK2230.25582508
149RPS6KA60.25548748
150ADRBK10.25344031
151MAP3K70.24498701
152ATR0.23926587
153TRIM280.23885090
154SGK10.22008468
155PDK10.21940845
156CDK20.21816476
157CDK10.20809694
158RPS6KL10.20222744
159RPS6KC10.20222744
160GSK3B0.19870173
161MAP2K10.19705200
162JAK30.19528309
163ERBB40.17701441
164MAP3K50.17373024
165BRD40.14742846
166MAPK90.14238464

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001005.23952563
2Base excision repair_Homo sapiens_hsa034105.09809238
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.90567361
4Fatty acid elongation_Homo sapiens_hsa000623.55200939
5ECM-receptor interaction_Homo sapiens_hsa045123.28473638
6Systemic lupus erythematosus_Homo sapiens_hsa053222.87706944
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86581544
8Alcoholism_Homo sapiens_hsa050342.68226335
9Basal transcription factors_Homo sapiens_hsa030222.65899552
10Fatty acid biosynthesis_Homo sapiens_hsa000612.54818833
11Ether lipid metabolism_Homo sapiens_hsa005652.45045120
12Circadian rhythm_Homo sapiens_hsa047102.38486085
13Hedgehog signaling pathway_Homo sapiens_hsa043402.32532326
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23421244
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06371556
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06057450
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96321762
18Sulfur relay system_Homo sapiens_hsa041221.96135296
19Selenocompound metabolism_Homo sapiens_hsa004501.96039209
20Protein digestion and absorption_Homo sapiens_hsa049741.93552529
21Folate biosynthesis_Homo sapiens_hsa007901.92063317
22Phototransduction_Homo sapiens_hsa047441.91589864
23Basal cell carcinoma_Homo sapiens_hsa052171.89521850
24Inositol phosphate metabolism_Homo sapiens_hsa005621.85749460
25Cell cycle_Homo sapiens_hsa041101.78811917
26Arginine and proline metabolism_Homo sapiens_hsa003301.75840720
27Axon guidance_Homo sapiens_hsa043601.63310995
28Sulfur metabolism_Homo sapiens_hsa009201.59920451
29Hippo signaling pathway_Homo sapiens_hsa043901.59306467
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59165272
31Wnt signaling pathway_Homo sapiens_hsa043101.57013852
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56436538
33RNA transport_Homo sapiens_hsa030131.55739807
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51928470
35Histidine metabolism_Homo sapiens_hsa003401.49707326
36Small cell lung cancer_Homo sapiens_hsa052221.49435411
37Sphingolipid metabolism_Homo sapiens_hsa006001.49092460
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46659028
39Focal adhesion_Homo sapiens_hsa045101.44903925
40Calcium signaling pathway_Homo sapiens_hsa040201.42625634
41Fructose and mannose metabolism_Homo sapiens_hsa000511.41529977
42TGF-beta signaling pathway_Homo sapiens_hsa043501.40873826
43Protein export_Homo sapiens_hsa030601.38434509
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35234350
45Linoleic acid metabolism_Homo sapiens_hsa005911.29584968
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29286357
47RNA polymerase_Homo sapiens_hsa030201.25389173
48Fanconi anemia pathway_Homo sapiens_hsa034601.23382463
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21239887
50RNA degradation_Homo sapiens_hsa030181.20465267
51Tight junction_Homo sapiens_hsa045301.18284255
52Viral carcinogenesis_Homo sapiens_hsa052031.17627278
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16626069
54Long-term depression_Homo sapiens_hsa047301.14865665
55Renal cell carcinoma_Homo sapiens_hsa052111.14219023
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06704780
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04405922
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98398522
59Gap junction_Homo sapiens_hsa045400.94950821
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94203947
61GABAergic synapse_Homo sapiens_hsa047270.93833351
62Butanoate metabolism_Homo sapiens_hsa006500.93621210
63Fatty acid metabolism_Homo sapiens_hsa012120.90255662
64Estrogen signaling pathway_Homo sapiens_hsa049150.90218726
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90159174
66Dorso-ventral axis formation_Homo sapiens_hsa043200.88204196
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85800526
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85626615
69Nitrogen metabolism_Homo sapiens_hsa009100.85196786
70Serotonergic synapse_Homo sapiens_hsa047260.84075127
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83763457
72mTOR signaling pathway_Homo sapiens_hsa041500.80028599
73Arachidonic acid metabolism_Homo sapiens_hsa005900.77444409
74Melanogenesis_Homo sapiens_hsa049160.75169515
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74301788
76Adherens junction_Homo sapiens_hsa045200.73323389
77Notch signaling pathway_Homo sapiens_hsa043300.71911722
78Ras signaling pathway_Homo sapiens_hsa040140.71737393
79Ovarian steroidogenesis_Homo sapiens_hsa049130.71678274
80Glutathione metabolism_Homo sapiens_hsa004800.70540860
81Endocytosis_Homo sapiens_hsa041440.70393018
82FoxO signaling pathway_Homo sapiens_hsa040680.70200584
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.70090265
84Gastric acid secretion_Homo sapiens_hsa049710.69741318
85Proteoglycans in cancer_Homo sapiens_hsa052050.66998586
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66048959
87Oocyte meiosis_Homo sapiens_hsa041140.65419270
88Cocaine addiction_Homo sapiens_hsa050300.64914885
89Prostate cancer_Homo sapiens_hsa052150.64465336
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63439618
91Homologous recombination_Homo sapiens_hsa034400.62209150
92Glutamatergic synapse_Homo sapiens_hsa047240.62089212
93ErbB signaling pathway_Homo sapiens_hsa040120.59356990
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58987355
95Olfactory transduction_Homo sapiens_hsa047400.58720535
96Choline metabolism in cancer_Homo sapiens_hsa052310.58181376
97Phagosome_Homo sapiens_hsa041450.58134333
98Caffeine metabolism_Homo sapiens_hsa002320.56731180
99Cholinergic synapse_Homo sapiens_hsa047250.56696649
100Bladder cancer_Homo sapiens_hsa052190.56629401
101MicroRNAs in cancer_Homo sapiens_hsa052060.56336325
102cAMP signaling pathway_Homo sapiens_hsa040240.55279043
103Phenylalanine metabolism_Homo sapiens_hsa003600.55251500
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55039170
105p53 signaling pathway_Homo sapiens_hsa041150.54296686
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53663880
107Malaria_Homo sapiens_hsa051440.53465847
108Mineral absorption_Homo sapiens_hsa049780.52613773
109Dilated cardiomyopathy_Homo sapiens_hsa054140.52421971
110Rap1 signaling pathway_Homo sapiens_hsa040150.52210964
111beta-Alanine metabolism_Homo sapiens_hsa004100.51336710
112Insulin secretion_Homo sapiens_hsa049110.50891468
113Fatty acid degradation_Homo sapiens_hsa000710.49736015
114Taste transduction_Homo sapiens_hsa047420.49701165
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49459074
116Vibrio cholerae infection_Homo sapiens_hsa051100.48967641
117Vitamin digestion and absorption_Homo sapiens_hsa049770.47817627
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46965860
119Morphine addiction_Homo sapiens_hsa050320.45997430
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.45691469
121Regulation of autophagy_Homo sapiens_hsa041400.45328731
122Pathways in cancer_Homo sapiens_hsa052000.44854307
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.43710762
124Amoebiasis_Homo sapiens_hsa051460.42306618
125MAPK signaling pathway_Homo sapiens_hsa040100.42004530
126Thyroid cancer_Homo sapiens_hsa052160.41844298
127Lysosome_Homo sapiens_hsa041420.41668354
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41310394
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41281469
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41213380
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40890061
132Salivary secretion_Homo sapiens_hsa049700.40133530
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39956439
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37863846
135Melanoma_Homo sapiens_hsa052180.35914213
136PPAR signaling pathway_Homo sapiens_hsa033200.35542007
137Oxidative phosphorylation_Homo sapiens_hsa001900.35496298
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35476913
139VEGF signaling pathway_Homo sapiens_hsa043700.35290065
140Vitamin B6 metabolism_Homo sapiens_hsa007500.34448611
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34083237
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32963444
143Amphetamine addiction_Homo sapiens_hsa050310.32556538
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.32372698
145Pancreatic secretion_Homo sapiens_hsa049720.31636915
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.31354719
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31081448
148Glucagon signaling pathway_Homo sapiens_hsa049220.30915081
149Cardiac muscle contraction_Homo sapiens_hsa042600.30298942
150Alzheimers disease_Homo sapiens_hsa050100.29413244
151Dopaminergic synapse_Homo sapiens_hsa047280.28512485
152GnRH signaling pathway_Homo sapiens_hsa049120.27443805
153Collecting duct acid secretion_Homo sapiens_hsa049660.27366171
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27352361
155Circadian entrainment_Homo sapiens_hsa047130.26869538
156Renin secretion_Homo sapiens_hsa049240.26510234
157Chronic myeloid leukemia_Homo sapiens_hsa052200.25533618
158Lysine degradation_Homo sapiens_hsa003100.24897133
159Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24424380
160mRNA surveillance pathway_Homo sapiens_hsa030150.23601606

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