SP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)7.17189570
2serotonin receptor signaling pathway (GO:0007210)6.75225448
3limb bud formation (GO:0060174)6.48376716
4negative regulation of mast cell activation (GO:0033004)6.05928063
5glial cell proliferation (GO:0014009)5.82708143
6regulation of hippo signaling (GO:0035330)5.66326455
7xenobiotic catabolic process (GO:0042178)5.39143656
8glucuronate metabolic process (GO:0019585)5.22685868
9uronic acid metabolic process (GO:0006063)5.22685868
10negative regulation of transcription regulatory region DNA binding (GO:2000678)5.16895236
11cellular glucuronidation (GO:0052695)4.82729898
12phenylpropanoid metabolic process (GO:0009698)4.75211276
13neuron cell-cell adhesion (GO:0007158)4.74065740
14generation of neurons (GO:0048699)4.63560158
15cardiac ventricle formation (GO:0003211)4.40739336
16presynaptic membrane assembly (GO:0097105)4.37032648
17postsynaptic membrane organization (GO:0001941)4.33900034
18central nervous system projection neuron axonogenesis (GO:0021952)4.30627839
19response to nitrosative stress (GO:0051409)4.15878929
20lung secretory cell differentiation (GO:0061140)4.07180694
21cell differentiation involved in metanephros development (GO:0072202)4.05715894
22facial nerve structural organization (GO:0021612)4.05430374
23sympathetic nervous system development (GO:0048485)4.04377734
24cranial nerve morphogenesis (GO:0021602)3.97513097
25hindbrain development (GO:0030902)3.96627075
26cardiac chamber formation (GO:0003207)3.95941044
27glomerulus development (GO:0032835)3.92278877
28negative regulation of stem cell proliferation (GO:2000647)3.91676491
29paraxial mesoderm development (GO:0048339)3.91571125
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.87732311
31convergent extension (GO:0060026)3.85317600
32planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83372897
33replicative senescence (GO:0090399)3.75995372
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.69588898
35outer ear morphogenesis (GO:0042473)3.64857720
36regulation of timing of cell differentiation (GO:0048505)3.63909179
37neural tube formation (GO:0001841)3.61650455
38regulation of penile erection (GO:0060405)3.60941879
39kidney morphogenesis (GO:0060993)3.58885992
40L-serine metabolic process (GO:0006563)3.58489397
41presynaptic membrane organization (GO:0097090)3.56844692
42negative regulation of keratinocyte proliferation (GO:0010839)3.56804723
43centriole assembly (GO:0098534)3.56695709
44one-carbon compound transport (GO:0019755)3.53616865
45positive regulation of neuroblast proliferation (GO:0002052)3.52682263
46cerebral cortex radially oriented cell migration (GO:0021799)3.50308797
47pyrimidine nucleobase catabolic process (GO:0006208)3.49725495
48regulation of heat generation (GO:0031650)3.49695921
49lens morphogenesis in camera-type eye (GO:0002089)3.49030714
50chromatin remodeling at centromere (GO:0031055)3.47822288
51heterochromatin organization (GO:0070828)3.46750591
52pharyngeal system development (GO:0060037)3.45778613
53regulation of helicase activity (GO:0051095)3.43276280
54tongue development (GO:0043586)3.42986727
55nucleotide transmembrane transport (GO:1901679)3.40850365
56negative regulation of nitric-oxide synthase activity (GO:0051001)3.39925447
57bone remodeling (GO:0046849)3.39726559
58regulation of development, heterochronic (GO:0040034)3.33892329
59neural crest cell development (GO:0014032)3.33525920
60centriole replication (GO:0007099)3.31432689
61regulation of posttranscriptional gene silencing (GO:0060147)3.28528926
62regulation of gene silencing by miRNA (GO:0060964)3.28528926
63regulation of gene silencing by RNA (GO:0060966)3.28528926
64embryonic digestive tract morphogenesis (GO:0048557)3.27809104
65regulation of mitotic spindle checkpoint (GO:1903504)3.24797534
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24797534
67pre-miRNA processing (GO:0031054)3.24720892
68ribosomal small subunit assembly (GO:0000028)3.23877474
69cell proliferation in forebrain (GO:0021846)3.23644537
70cellular response to gamma radiation (GO:0071480)3.23380531
71regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.23346451
72notochord development (GO:0030903)3.19638341
73sterol catabolic process (GO:0016127)3.19474573
74cholesterol catabolic process (GO:0006707)3.19474573
75regulation of non-canonical Wnt signaling pathway (GO:2000050)3.18901728
76neuron fate determination (GO:0048664)3.17459489
77dorsal/ventral axis specification (GO:0009950)3.16712966
78nonmotile primary cilium assembly (GO:0035058)3.16541232
79central nervous system neuron axonogenesis (GO:0021955)3.16219775
80cell differentiation involved in kidney development (GO:0061005)3.15731796
81negative regulation of DNA binding (GO:0043392)3.15352803
82limb development (GO:0060173)3.14920650
83appendage development (GO:0048736)3.14920650
84neuron projection extension involved in neuron projection guidance (GO:1902284)3.10826912
85axon extension involved in axon guidance (GO:0048846)3.10826912
86lateral sprouting from an epithelium (GO:0060601)3.09545220
87positive regulation of heat generation (GO:0031652)3.09152605
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08661002
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.08661002
90vocalization behavior (GO:0071625)3.07392854
91regulation of cell fate specification (GO:0042659)3.06881339
92somite development (GO:0061053)3.06570150
93CENP-A containing nucleosome assembly (GO:0034080)3.06271956
94kinetochore organization (GO:0051383)3.05494801
95spinal cord development (GO:0021510)3.04149515
96negative regulation of oligodendrocyte differentiation (GO:0048715)3.02194222
97regulation of mesoderm development (GO:2000380)3.02094047
98mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.01113088
99neuronal stem cell maintenance (GO:0097150)3.00473661
100response to cocaine (GO:0042220)2.98599427
101head development (GO:0060322)2.98446029
102eyelid development in camera-type eye (GO:0061029)2.95696855
103olfactory bulb development (GO:0021772)2.94948688
104synaptic vesicle endocytosis (GO:0048488)2.93870391
105retinal ganglion cell axon guidance (GO:0031290)2.93812243
106mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91737837
107positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91737837
108axonal fasciculation (GO:0007413)2.91034485
109kinetochore assembly (GO:0051382)2.89837493
110establishment of planar polarity (GO:0001736)2.89814247
111establishment of tissue polarity (GO:0007164)2.89814247
112radial glial cell differentiation (GO:0060019)2.88410988
113dentate gyrus development (GO:0021542)2.87700174
114regulation of skeletal muscle contraction (GO:0014819)2.86913947
115energy homeostasis (GO:0097009)2.86607501
116oligodendrocyte differentiation (GO:0048709)2.85331224
117metanephric mesenchyme development (GO:0072075)2.82490705
118calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.82289963
119short-term memory (GO:0007614)2.82085275
120post-anal tail morphogenesis (GO:0036342)2.81116531
121cranial nerve structural organization (GO:0021604)2.80951544
122histone deubiquitination (GO:0016578)2.79277464
123startle response (GO:0001964)2.79222971
124middle ear morphogenesis (GO:0042474)2.78301955
125positive regulation of neural precursor cell proliferation (GO:2000179)2.76630085
126regulation of transcription regulatory region DNA binding (GO:2000677)2.75559569
127intraciliary transport (GO:0042073)2.74082898
128ephrin receptor signaling pathway (GO:0048013)2.73991803
129somite rostral/caudal axis specification (GO:0032525)2.73702232
130digestive tract morphogenesis (GO:0048546)2.73517694
131inner ear receptor stereocilium organization (GO:0060122)2.73442543
132platelet dense granule organization (GO:0060155)2.72947565
133microtubule depolymerization (GO:0007019)2.72313352
134cell migration in hindbrain (GO:0021535)2.72265541
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.71958321
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.71958321
137mesenchymal cell development (GO:0014031)2.71662589
138Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.71443724
139DNA replication-independent nucleosome assembly (GO:0006336)2.70267253
140DNA replication-independent nucleosome organization (GO:0034724)2.70267253
141regulation of gene expression by genetic imprinting (GO:0006349)2.69515909
142developmental pigmentation (GO:0048066)2.69420148
143negative regulation of glycogen metabolic process (GO:0070874)2.68235999
144forebrain neuron differentiation (GO:0021879)2.68181974
145regulation of establishment of planar polarity (GO:0090175)2.67919949
146negative regulation of glial cell differentiation (GO:0045686)2.67448719
147morphogenesis of an epithelial sheet (GO:0002011)2.66105138
148protein localization to microtubule (GO:0035372)2.66032845
149inner ear morphogenesis (GO:0042472)2.65565045
150cardiac left ventricle morphogenesis (GO:0003214)2.64214061
151pituitary gland development (GO:0021983)2.63681722
152regulation of cardioblast proliferation (GO:0003264)2.62147991
153regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62147991
154regulation of cilium movement (GO:0003352)2.61806667
155otic vesicle formation (GO:0030916)2.56360153
156histone exchange (GO:0043486)2.53840071
157nucleobase catabolic process (GO:0046113)2.51428185
158DNA damage response, detection of DNA damage (GO:0042769)2.48019807
159negative regulation of astrocyte differentiation (GO:0048712)2.47781522
160ATP-dependent chromatin remodeling (GO:0043044)2.46436825
161neuron recognition (GO:0008038)2.45964421
162resolution of meiotic recombination intermediates (GO:0000712)2.40780401
163regulation of telomere maintenance via telomerase (GO:0032210)2.39254058
164apical protein localization (GO:0045176)2.38039257
165inner ear receptor cell development (GO:0060119)2.37534816
166chromatin assembly (GO:0031497)2.35273463
167regulation of cell fate commitment (GO:0010453)2.35192990
168cochlea morphogenesis (GO:0090103)2.32232870
169DNA replication-dependent nucleosome organization (GO:0034723)2.31356970
170DNA replication-dependent nucleosome assembly (GO:0006335)2.31356970
171negative regulation of cell fate specification (GO:0009996)2.30646080
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30087126
173* dorsal/ventral pattern formation (GO:0009953)2.28334027
174transmission of nerve impulse (GO:0019226)2.28269981
175ectodermal placode formation (GO:0060788)2.28012495
176cellular response to cholesterol (GO:0071397)2.27900677
177regulation of neuroblast proliferation (GO:1902692)2.26839774
178establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.26601822
179non-canonical Wnt signaling pathway (GO:0035567)2.25825087
180negative regulation of epidermis development (GO:0045683)2.25355080
181artery development (GO:0060840)2.25292211
182camera-type eye morphogenesis (GO:0048593)2.24943374
183protein localization to kinetochore (GO:0034501)2.24369822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55483713
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.59832773
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22022087
4GBX2_23144817_ChIP-Seq_PC3_Human3.20257033
5E2F7_22180533_ChIP-Seq_HELA_Human3.04126977
6TAF15_26573619_Chip-Seq_HEK293_Human2.92249174
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.89375328
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62280390
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60701836
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58670642
11* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.39297494
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.36967756
13* CBX2_27304074_Chip-Seq_ESCs_Mouse2.36903390
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30052338
15IRF1_19129219_ChIP-ChIP_H3396_Human2.26294935
16* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.22380530
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20214026
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.17995359
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.17820692
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17389843
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15898769
22* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07543984
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.07430278
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.06806640
25FUS_26573619_Chip-Seq_HEK293_Human2.03094016
26* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02414615
27* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02414615
28* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99696723
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98565058
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96268288
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95349870
32* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95332729
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93241014
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90480213
35* P300_19829295_ChIP-Seq_ESCs_Human1.89590052
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88744591
37* RNF2_27304074_Chip-Seq_NSC_Mouse1.88181826
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87908170
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84068355
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82837404
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82468728
42* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82210378
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.80922463
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78109102
45ZNF274_21170338_ChIP-Seq_K562_Hela1.76395839
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75983924
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75634189
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73710187
49IGF1R_20145208_ChIP-Seq_DFB_Human1.72602851
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69892833
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68983345
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66587859
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63264666
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63029498
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56355595
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.56051842
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55038527
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.52726080
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.50391793
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.49238735
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.47851952
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47274861
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47246761
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47246761
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47246761
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46713486
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46220828
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46070963
69* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46017978
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45840106
71EWS_26573619_Chip-Seq_HEK293_Human1.44510846
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44369615
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43247907
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43178140
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43132035
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41321646
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40735549
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40535208
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40309173
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39807777
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.39721242
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.38629865
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.38012585
84TP53_18474530_ChIP-ChIP_U2OS_Human1.37764272
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.37484497
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.37424477
87* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34472731
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33959677
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33926587
90ER_23166858_ChIP-Seq_MCF-7_Human1.29883428
91* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28974027
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28797020
93P53_22387025_ChIP-Seq_ESCs_Mouse1.28706000
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27193428
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24396807
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24396807
97AR_25329375_ChIP-Seq_VCAP_Human1.24205350
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23575093
99* MYC_18940864_ChIP-ChIP_HL60_Human1.23540828
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22793498
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22505394
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22303501
103AHR_22903824_ChIP-Seq_MCF-7_Human1.22190886
104* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21893724
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21033056
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20827959
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20584997
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.20481392
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19914277
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19021831
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18971530
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18036346
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.17602569
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17027339
115* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14626399
116SOX9_26525672_Chip-Seq_HEART_Mouse1.13901168
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.13866320
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.11853000
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10808951
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.10586119
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.10380210
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08975739
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.08973119
124* TP53_20018659_ChIP-ChIP_R1E_Mouse1.08675983
125* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08286449
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07556029
127* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07555116
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07102882
129* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06683922
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06532069
131KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06341563
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05301702
133* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04764938
134* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04162729
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03438232
136NMYC_18555785_Chip-Seq_ESCs_Mouse1.03430227
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03276120
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02915911
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02911503
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01617330
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01617330
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01000589
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99992405
144* AR_21909140_ChIP-Seq_LNCAP_Human0.99704822
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.98166413
146* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98076947
147* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98000150
148* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97853138
149RUNX2_22187159_ChIP-Seq_PCA_Human0.97825640
150* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97290619
151ELK1_19687146_ChIP-ChIP_HELA_Human0.96793801
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96567612
153P300_18555785_Chip-Seq_ESCs_Mouse0.96140757
154* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95666003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium6.38339013
2MP0005499_abnormal_olfactory_system6.03607646
3MP0005394_taste/olfaction_phenotype6.03607646
4MP0006292_abnormal_olfactory_placode5.72741212
5MP0001984_abnormal_olfaction3.55778767
6MP0010030_abnormal_orbit_morphology2.99223602
7MP0003787_abnormal_imprinting2.86606870
8MP0001293_anophthalmia2.85263505
9MP0003122_maternal_imprinting2.81170777
10MP0002653_abnormal_ependyma_morphology2.75535867
11MP0000537_abnormal_urethra_morphology2.74339799
12MP0000566_synostosis2.61652853
13MP0002822_catalepsy2.48254328
14MP0000049_abnormal_middle_ear2.26820068
15MP0000678_abnormal_parathyroid_gland2.19150689
16MP0002009_preneoplasia2.10439582
17MP0010386_abnormal_urinary_bladder2.10028279
18MP0004885_abnormal_endolymph2.08779820
19MP0002697_abnormal_eye_size2.03013334
20MP0002277_abnormal_respiratory_mucosa1.99209615
21MP0003880_abnormal_central_pattern1.97236610
22MP0002177_abnormal_outer_ear1.93914789
23MP0001188_hyperpigmentation1.93711026
24MP0000015_abnormal_ear_pigmentation1.90953546
25MP0003938_abnormal_ear_development1.87221959
26MP0004134_abnormal_chest_morphology1.81014049
27MP0001529_abnormal_vocalization1.77124593
28MP0002735_abnormal_chemical_nociception1.72004521
29MP0000778_abnormal_nervous_system1.70255884
30* MP0002233_abnormal_nose_morphology1.66760498
31MP0003861_abnormal_nervous_system1.59701291
32MP0005646_abnormal_pituitary_gland1.59204872
33MP0002938_white_spotting1.56505520
34MP0002092_abnormal_eye_morphology1.55799254
35MP0003119_abnormal_digestive_system1.55424833
36MP0005408_hypopigmentation1.55003813
37MP0003123_paternal_imprinting1.53355282
38MP0003693_abnormal_embryo_hatching1.52610001
39MP0005075_abnormal_melanosome_morpholog1.51107517
40* MP0000428_abnormal_craniofacial_morphol1.50672389
41MP0005257_abnormal_intraocular_pressure1.50016067
42MP0000631_abnormal_neuroendocrine_gland1.47459528
43MP0003385_abnormal_body_wall1.46006557
44MP0001177_atelectasis1.42664484
45MP0002249_abnormal_larynx_morphology1.41214408
46MP0002234_abnormal_pharynx_morphology1.30850602
47MP0002102_abnormal_ear_morphology1.30076270
48MP0004381_abnormal_hair_follicle1.27667110
49MP0000534_abnormal_ureter_morphology1.26881317
50MP0001299_abnormal_eye_distance/1.26040724
51* MP0002111_abnormal_tail_morphology1.25829988
52MP0002084_abnormal_developmental_patter1.23325999
53* MP0003755_abnormal_palate_morphology1.21811621
54MP0001346_abnormal_lacrimal_gland1.20599273
55MP0009250_abnormal_appendicular_skeleto1.19082808
56MP0003567_abnormal_fetal_cardiomyocyte1.17838642
57MP0005174_abnormal_tail_pigmentation1.17449652
58MP0004133_heterotaxia1.13119818
59* MP0002152_abnormal_brain_morphology1.12369780
60* MP0002085_abnormal_embryonic_tissue1.11826870
61MP0003718_maternal_effect1.11164143
62MP0003942_abnormal_urinary_system1.10944366
63MP0005391_vision/eye_phenotype1.10740489
64MP0008058_abnormal_DNA_repair1.10144035
65MP0002736_abnormal_nociception_after1.09774421
66MP0000026_abnormal_inner_ear1.09125482
67MP0008932_abnormal_embryonic_tissue1.08557562
68MP0005171_absent_coat_pigmentation1.07492040
69MP0000762_abnormal_tongue_morphology1.07087992
70MP0005248_abnormal_Harderian_gland1.06590455
71MP0009053_abnormal_anal_canal1.04982188
72MP0009379_abnormal_foot_pigmentation1.04937349
73MP0000432_abnormal_head_morphology1.04413493
74MP0002751_abnormal_autonomic_nervous1.03899451
75MP0004957_abnormal_blastocyst_morpholog1.02241034
76MP0000955_abnormal_spinal_cord1.01300454
77MP0004197_abnormal_fetal_growth/weight/0.99880654
78MP0003315_abnormal_perineum_morphology0.99569891
79MP0000538_abnormal_urinary_bladder0.98719209
80MP0003878_abnormal_ear_physiology0.96716854
81MP0005377_hearing/vestibular/ear_phenot0.96716854
82MP0002184_abnormal_innervation0.95981051
83MP0002557_abnormal_social/conspecific_i0.95863200
84MP0002752_abnormal_somatic_nervous0.93891193
85MP0000383_abnormal_hair_follicle0.93482965
86MP0000613_abnormal_salivary_gland0.92337655
87MP0005195_abnormal_posterior_eye0.91722108
88MP0006276_abnormal_autonomic_nervous0.91626763
89MP0002098_abnormal_vibrissa_morphology0.91134278
90MP0001919_abnormal_reproductive_system0.91036506
91MP0001324_abnormal_eye_pigmentation0.91025903
92MP0008875_abnormal_xenobiotic_pharmacok0.89860879
93MP0005395_other_phenotype0.89462678
94MP0008877_abnormal_DNA_methylation0.88259779
95* MP0002081_perinatal_lethality0.86450915
96MP0002116_abnormal_craniofacial_bone0.86386378
97MP0009672_abnormal_birth_weight0.84614588
98MP0005647_abnormal_sex_gland0.82583610
99MP0009745_abnormal_behavioral_response0.81350424
100MP0003136_yellow_coat_color0.78946776
101MP0002210_abnormal_sex_determination0.78165873
102MP0001270_distended_abdomen0.76863747
103MP0002282_abnormal_trachea_morphology0.76563877
104MP0001486_abnormal_startle_reflex0.76424022
105MP0003121_genomic_imprinting0.75905056
106MP0002882_abnormal_neuron_morphology0.75904914
107MP0006072_abnormal_retinal_apoptosis0.75793493
108MP0002168_other_aberrant_phenotype0.75779981
109MP0002163_abnormal_gland_morphology0.75747885
110MP0002160_abnormal_reproductive_system0.75553894
111MP0003935_abnormal_craniofacial_develop0.74120195
112MP0010094_abnormal_chromosome_stability0.74021091
113MP0005380_embryogenesis_phenotype0.73801616
114MP0001672_abnormal_embryogenesis/_devel0.73801616
115MP0003943_abnormal_hepatobiliary_system0.73564647
116MP0001986_abnormal_taste_sensitivity0.73539333
117MP0001485_abnormal_pinna_reflex0.73196651
118MP0001286_abnormal_eye_development0.73149713
119MP0001963_abnormal_hearing_physiology0.72697262
120MP0001697_abnormal_embryo_size0.72535603
121MP0005389_reproductive_system_phenotype0.71836477
122MP0001905_abnormal_dopamine_level0.71207326
123MP0005197_abnormal_uvea_morphology0.71122945
124MP0009703_decreased_birth_body0.70721392
125MP0005187_abnormal_penis_morphology0.70585513
126MP0003077_abnormal_cell_cycle0.70494793
127MP0003941_abnormal_skin_development0.70191940
128MP0004859_abnormal_synaptic_plasticity0.69714370
129MP0004742_abnormal_vestibular_system0.69561950
130MP0008007_abnormal_cellular_replicative0.68876974
131MP0002132_abnormal_respiratory_system0.68324609
132MP0000681_abnormal_thyroid_gland0.67685415
133* MP0002109_abnormal_limb_morphology0.67546797
134MP0009384_cardiac_valve_regurgitation0.66859582
135MP0003111_abnormal_nucleus_morphology0.66584252
136MP0003786_premature_aging0.66074102
137MP0002638_abnormal_pupillary_reflex0.65610131
138* MP0003937_abnormal_limbs/digits/tail_de0.65582104
139MP0001340_abnormal_eyelid_morphology0.64794417
140MP0002876_abnormal_thyroid_physiology0.64252758
141MP0001186_pigmentation_phenotype0.63670403
142MP0000579_abnormal_nail_morphology0.63085219
143MP0000372_irregular_coat_pigmentation0.62306264
144MP0005388_respiratory_system_phenotype0.61333062
145MP0002133_abnormal_respiratory_system0.61333062
146MP0005409_darkened_coat_color0.60285264
147MP0003890_abnormal_embryonic-extraembry0.58694424
148MP0003186_abnormal_redox_activity0.57281722
149MP0003195_calcinosis0.56631346
150MP0000647_abnormal_sebaceous_gland0.56367304
151MP0002837_dystrophic_cardiac_calcinosis0.54902638
152MP0002095_abnormal_skin_pigmentation0.54699915

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)4.08346826
2Hyperventilation (HP:0002883)3.73701773
3Abnormality of the intervertebral disk (HP:0005108)3.63014013
4Stomach cancer (HP:0012126)3.57213132
5Febrile seizures (HP:0002373)3.49376838
6Cupped ear (HP:0000378)3.40843714
7Colon cancer (HP:0003003)3.33429093
8Anophthalmia (HP:0000528)3.26728972
9Prostate neoplasm (HP:0100787)3.25786232
10Split foot (HP:0001839)3.24522100
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.20217306
12Hypoplasia of the fovea (HP:0007750)3.20217306
13Hepatoblastoma (HP:0002884)3.03955544
14Tented upper lip vermilion (HP:0010804)2.98988359
15Optic nerve hypoplasia (HP:0000609)2.95017350
16Abnormality of the aortic arch (HP:0012303)2.90455461
17Median cleft lip (HP:0000161)2.87083428
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86438739
19Partial duplication of thumb phalanx (HP:0009944)2.83256762
20Esophageal atresia (HP:0002032)2.82376290
21High anterior hairline (HP:0009890)2.80166419
22Rib fusion (HP:0000902)2.79564920
23Oligodactyly (HP:0012165)2.78469263
24Type 2 muscle fiber atrophy (HP:0003554)2.73256846
25Abnormality of the 4th metacarpal (HP:0010012)2.66206527
26Short 4th metacarpal (HP:0010044)2.65461662
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65461662
28Absent septum pellucidum (HP:0001331)2.63301326
29Abnormality of hair growth rate (HP:0011363)2.62784160
30Slow-growing hair (HP:0002217)2.62784160
31Hypothermia (HP:0002045)2.61322902
32Abnormality of the anterior horn cell (HP:0006802)2.60428128
33Degeneration of anterior horn cells (HP:0002398)2.60428128
34Intestinal atresia (HP:0011100)2.59966890
35Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.59432144
36Popliteal pterygium (HP:0009756)2.52519236
37Protruding tongue (HP:0010808)2.52274496
38Supernumerary spleens (HP:0009799)2.51095180
39Oligodactyly (hands) (HP:0001180)2.47941203
40Hypoplastic pelvis (HP:0008839)2.47608032
41Chronic hepatic failure (HP:0100626)2.45763289
42Papillary thyroid carcinoma (HP:0002895)2.45102038
43Aplasia/Hypoplasia of the patella (HP:0006498)2.44133225
44Gastrointestinal atresia (HP:0002589)2.42953017
45Sclerocornea (HP:0000647)2.42527872
46Abnormality of the fovea (HP:0000493)2.41136179
47Renal dysplasia (HP:0000110)2.40550354
48Broad thumb (HP:0011304)2.38748857
49Preauricular pit (HP:0004467)2.35938831
50Periauricular skin pits (HP:0100277)2.35938831
51Maternal diabetes (HP:0009800)2.33585939
52Partial duplication of the phalanx of hand (HP:0009999)2.33546709
53Abnormality of the labia minora (HP:0012880)2.33352260
54Hemivertebrae (HP:0002937)2.30638123
55Muscle fiber atrophy (HP:0100295)2.29983304
56Abnormality of abdominal situs (HP:0011620)2.29586347
57Abdominal situs inversus (HP:0003363)2.29586347
58Vitreoretinal degeneration (HP:0000655)2.28472346
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28211409
60Ectopic kidney (HP:0000086)2.28111617
61True hermaphroditism (HP:0010459)2.25310544
62Abnormality of the septum pellucidum (HP:0007375)2.24735184
63Nephrogenic diabetes insipidus (HP:0009806)2.24035824
64Palpebral edema (HP:0100540)2.23752458
65Preaxial hand polydactyly (HP:0001177)2.22355836
66Abnormality of the metopic suture (HP:0005556)2.21029004
67Abnormal lung lobation (HP:0002101)2.20659517
68Clubbing of toes (HP:0100760)2.20618509
69Reticulocytopenia (HP:0001896)2.20288655
70Chromsome breakage (HP:0040012)2.20135482
71Preaxial foot polydactyly (HP:0001841)2.19947243
72Gait imbalance (HP:0002141)2.16750308
73Abnormality of the preputium (HP:0100587)2.16469812
74Renal hypoplasia (HP:0000089)2.15897520
75Nasolacrimal duct obstruction (HP:0000579)2.15264411
76Thyroid carcinoma (HP:0002890)2.14560772
77Hyperglycinemia (HP:0002154)2.12254622
78Morphological abnormality of the middle ear (HP:0008609)2.11791954
79Congenital primary aphakia (HP:0007707)2.11380204
80Widely spaced teeth (HP:0000687)2.11339382
81Medial flaring of the eyebrow (HP:0010747)2.11038932
82Septo-optic dysplasia (HP:0100842)2.10358996
83Fair hair (HP:0002286)2.09959360
84Abnormality of the prostate (HP:0008775)2.09615843
85Focal motor seizures (HP:0011153)2.09329713
86Small hand (HP:0200055)2.08822742
87Postaxial foot polydactyly (HP:0001830)2.08805276
88Abnormality of the renal collecting system (HP:0004742)2.08292348
89Adrenal hypoplasia (HP:0000835)2.08111612
90Fibular hypoplasia (HP:0003038)2.07947516
91Aplasia/Hypoplasia of the breasts (HP:0010311)2.07529944
92Sleep apnea (HP:0010535)2.06469475
93Anencephaly (HP:0002323)2.06421442
94Large eyes (HP:0001090)2.05388728
95Breast aplasia (HP:0100783)2.04955812
96Pancreatic fibrosis (HP:0100732)2.04504904
97Patellar aplasia (HP:0006443)2.04438894
98Limb dystonia (HP:0002451)2.02902146
99Broad phalanges of the hand (HP:0009768)2.01379032
100Optic nerve coloboma (HP:0000588)2.00286364
101Triphalangeal thumb (HP:0001199)1.99700918
102Aplasia/Hypoplasia of the lens (HP:0008063)1.99515006
103Fetal akinesia sequence (HP:0001989)1.99039292
104Duplication of thumb phalanx (HP:0009942)1.97853435
105Renal cortical cysts (HP:0000803)1.97433865
106Volvulus (HP:0002580)1.96857665
107Morphological abnormality of the inner ear (HP:0011390)1.96693841
108Abnormality of the middle phalanges of the toes (HP:0010183)1.96354187
109Hypoplastic scapulae (HP:0000882)1.96238612
110Aplasia/Hypoplasia of the scapulae (HP:0006713)1.96238612
111Diastasis recti (HP:0001540)1.95682647
112Abnormality of the diencephalon (HP:0010662)1.95429177
113Abnormality of cochlea (HP:0000375)1.95057731
114Capillary hemangiomas (HP:0005306)1.94819864
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.93697456
116Occipital encephalocele (HP:0002085)1.93480321
117Poor coordination (HP:0002370)1.93390480
118Abnormality of midbrain morphology (HP:0002418)1.92775005
119Molar tooth sign on MRI (HP:0002419)1.92775005
120Pancreatic cysts (HP:0001737)1.92364854
121Broad finger (HP:0001500)1.92299264
122Microglossia (HP:0000171)1.92001356
123Abnormality of the lacrimal duct (HP:0011481)1.91745927
124Nephronophthisis (HP:0000090)1.91346077
125Aplasia/Hypoplasia of the macula (HP:0008059)1.91331328
126Holoprosencephaly (HP:0001360)1.90990307
127Vertebral clefting (HP:0008428)1.90469892
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.89366100
129Synostosis of carpal bones (HP:0005048)1.89224353
130Absent eyebrow (HP:0002223)1.88201636
131Postaxial hand polydactyly (HP:0001162)1.87228322
132Horizontal nystagmus (HP:0000666)1.87067242
133Type I transferrin isoform profile (HP:0003642)1.86894138
134Cortical dysplasia (HP:0002539)1.86859855
135Bifid tongue (HP:0010297)1.86300348
136Renal tubular acidosis (HP:0001947)1.86186848
137Male pseudohermaphroditism (HP:0000037)1.86156693
138Synostosis involving the elbow (HP:0003938)1.84859915
139Humeroradial synostosis (HP:0003041)1.84859915
140Natal tooth (HP:0000695)1.84823605
141Nonprogressive disorder (HP:0003680)1.84542768
142Missing ribs (HP:0000921)1.84414918
143Weak cry (HP:0001612)1.84314980
144Abnormality of the antihelix (HP:0009738)1.83973799
145Progressive inability to walk (HP:0002505)1.83972257
146Hypoplasia of the ulna (HP:0003022)1.83706621
147Broad phalanx (HP:0006009)1.83326498
148Micropenis (HP:0000054)1.82367638
149Bilateral microphthalmos (HP:0007633)1.82177435
150Meckel diverticulum (HP:0002245)1.81658662
151Trigonocephaly (HP:0000243)1.81354239
152Osteomalacia (HP:0002749)1.80872534
153Cutaneous syndactyly (HP:0012725)1.80784243
154Stenosis of the external auditory canal (HP:0000402)1.80718635
155Broad foot (HP:0001769)1.80024448
15611 pairs of ribs (HP:0000878)1.79861092
157Broad alveolar ridges (HP:0000187)1.79718243
158Abnormality of the nasolacrimal system (HP:0000614)1.79652872
159Renal tubular dysfunction (HP:0000124)1.78671158
160Growth hormone deficiency (HP:0000824)1.78668082
161Absent radius (HP:0003974)1.77736483
162Facial hemangioma (HP:0000329)1.77632996
163Long clavicles (HP:0000890)1.76655452
164Spina bifida occulta (HP:0003298)1.76583101
165Vaginal atresia (HP:0000148)1.74363241
166Cutaneous finger syndactyly (HP:0010554)1.74174507
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.74014465
168Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73039760
169Abnormality of incisor morphology (HP:0011063)1.72865483
170Aplasia/Hypoplasia of the fibula (HP:0006492)1.72776957
171Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72133821
172Facial cleft (HP:0002006)1.71321061
173Broad long bones (HP:0005622)1.71084020
174Generalized hypopigmentation of hair (HP:0011358)1.70977604
175Abnormality of the nasal septum (HP:0000419)1.70284297
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69785647
177Aplasia involving forearm bones (HP:0009822)1.69560980
178Absent forearm bone (HP:0003953)1.69560980
179Aplasia involving bones of the extremities (HP:0009825)1.68875837
180Aplasia involving bones of the upper limbs (HP:0009823)1.68875837
181Aplasia of the phalanges of the hand (HP:0009802)1.68875837
182Asymmetry of the thorax (HP:0001555)1.68663694
183Dandy-Walker malformation (HP:0001305)1.67919094
184Abnormality of the ileum (HP:0001549)1.67786308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.99823301
2MAP2K73.69299050
3VRK13.21968296
4YES13.04288560
5CDC72.87104115
6ERBB32.81301835
7BRSK22.76961256
8TNIK2.69678513
9MAP3K42.68290443
10PLK42.46588182
11ZAK2.43157607
12MKNK22.39301908
13BMPR22.38800340
14MARK12.30594008
15WEE12.30575769
16WNK32.29971959
17LATS12.29532685
18SGK22.20126916
19MST42.19708611
20NUAK12.06111121
21BRD42.03440559
22SIK32.01410541
23MKNK12.01059107
24PRPF4B1.97081845
25DYRK31.91902041
26MAP3K101.91662614
27BCR1.85632472
28TYRO31.71848742
29SGK2231.69436204
30SGK4941.69436204
31TRIM281.62952975
32PBK1.61851545
33EIF2AK21.53862144
34DYRK21.52897114
35PLK31.50652568
36ADRBK21.43984394
37BRSK11.42678971
38EPHB21.40136326
39TAF11.37606171
40MUSK1.36421506
41FGFR21.33936889
42SGK31.29966115
43PINK11.26986550
44TTK1.24314192
45FGFR11.23657952
46CSNK1G21.20848942
47HIPK21.20844195
48BUB11.17352861
49PLK21.16114930
50CAMK1G1.14706626
51PLK11.12782843
52CSNK1G11.11092077
53NLK1.10628754
54MAPK151.08336071
55CCNB11.04706909
56PIK3CA1.04293074
57BMPR1B1.04119430
58MAP2K41.02721250
59AKT31.02377203
60CSNK1G31.01183923
61STK161.00493567
62PNCK0.97760732
63TGFBR10.97075640
64DYRK1B0.95989031
65STK38L0.95305191
66MAP3K30.94606617
67MAP4K20.93983096
68EEF2K0.92601173
69CSNK1A1L0.91844560
70CHEK20.90602950
71EPHA40.88664891
72MAPK130.87834319
73VRK20.86505985
74SIK20.85075778
75CDK190.85075713
76CAMK1D0.80590633
77NEK60.79732248
78CLK10.78976213
79SRPK10.78197045
80EPHA20.77492521
81NTRK30.74187112
82NTRK20.73571449
83BCKDK0.73530954
84PRKCE0.73503690
85TEC0.70884196
86OXSR10.70432954
87NEK10.67626062
88CDK30.67526211
89STK110.67425683
90PAK60.65564062
91PRKCH0.64858283
92MAP3K60.64632275
93MINK10.64426468
94CAMK2B0.64079939
95CDK80.63422752
96CAMK10.61530780
97IRAK40.61191275
98TLK10.60655030
99PASK0.60155762
100PRKD20.59500302
101MAP2K60.59306827
102PRKD30.59234340
103ATM0.58622570
104ROCK10.58031519
105ERBB40.57326349
106CDK11A0.56280925
107AURKB0.55699332
108TIE10.54249534
109CDK180.53941967
110ERBB20.53844841
111BRAF0.53051308
112CDK150.52156214
113MARK20.51910927
114RPS6KB10.51176211
115CDK20.50582307
116CHEK10.50188859
117DYRK1A0.49475927
118CDK10.49442498
119NEK20.48391067
120RPS6KA40.46699692
121IRAK10.45964552
122CDK140.45591208
123GRK70.45290971
124PRKCG0.44006255
125TNK20.42756491
126TAOK20.41922892
127CAMK2A0.41339294
128ACVR1B0.40957261
129BMX0.40765709
130CAMK40.40503758
131CAMK2G0.40280389
132RPS6KC10.39863684
133RPS6KL10.39863684
134MAP3K70.39771355
135MAPK80.39488511
136TAOK30.39307836
137FRK0.38857133
138STK240.38536050
139CHUK0.38455290
140KSR10.38331107
141CSNK1E0.37955872
142STK30.37514184
143RPS6KB20.37050706
144LMTK20.36775287
145PKN10.36212866
146MAP3K140.35095297
147PRKDC0.34936921
148ROCK20.34702994
149MAPK30.32670643
150AURKA0.32544612
151CAMK2D0.31484329
152UHMK10.30816139
153RPS6KA60.29746009
154CSNK1A10.28982636
155SGK10.28766981
156MAPK70.28720391
157IKBKB0.27197735
158ATR0.26500861
159PRKACA0.26437596
160MAPK40.26328874
161NME10.25284336

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.10974714
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.95852629
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.41395338
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.37774888
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.96844434
6Chemical carcinogenesis_Homo sapiens_hsa052042.93973790
7Sulfur relay system_Homo sapiens_hsa041222.73323455
8Sulfur metabolism_Homo sapiens_hsa009202.71850984
9Hedgehog signaling pathway_Homo sapiens_hsa043402.65213508
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54962438
11Base excision repair_Homo sapiens_hsa034102.37097201
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.34356441
13Steroid biosynthesis_Homo sapiens_hsa001002.33903999
14Taste transduction_Homo sapiens_hsa047422.15964211
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11562181
16Ribosome_Homo sapiens_hsa030102.11300225
17Non-homologous end-joining_Homo sapiens_hsa034502.07039305
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02029227
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98540917
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.95047018
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83240201
22Serotonergic synapse_Homo sapiens_hsa047261.77070818
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70702960
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70527802
25Retinol metabolism_Homo sapiens_hsa008301.64824628
26Propanoate metabolism_Homo sapiens_hsa006401.58989112
27Fanconi anemia pathway_Homo sapiens_hsa034601.56670303
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47324821
29RNA transport_Homo sapiens_hsa030131.46917290
30RNA degradation_Homo sapiens_hsa030181.41580701
31Collecting duct acid secretion_Homo sapiens_hsa049661.40083848
32Nicotine addiction_Homo sapiens_hsa050331.39938262
33Nucleotide excision repair_Homo sapiens_hsa034201.35405093
34beta-Alanine metabolism_Homo sapiens_hsa004101.32578904
35Glutathione metabolism_Homo sapiens_hsa004801.30244263
36One carbon pool by folate_Homo sapiens_hsa006701.29030932
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28441571
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27401499
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24436159
40DNA replication_Homo sapiens_hsa030301.18699953
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16581556
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16518874
43Starch and sucrose metabolism_Homo sapiens_hsa005001.15962145
44Melanogenesis_Homo sapiens_hsa049161.14405861
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13142078
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12776598
47TGF-beta signaling pathway_Homo sapiens_hsa043501.12648907
48Phototransduction_Homo sapiens_hsa047441.11042985
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09682739
50MicroRNAs in cancer_Homo sapiens_hsa052061.09435010
51Adherens junction_Homo sapiens_hsa045201.09246018
52Spliceosome_Homo sapiens_hsa030401.08643533
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06577466
54Protein export_Homo sapiens_hsa030601.05874612
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02916795
56Rheumatoid arthritis_Homo sapiens_hsa053231.01616441
57Lysine degradation_Homo sapiens_hsa003100.99534068
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.98852766
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.98496437
60Basal transcription factors_Homo sapiens_hsa030220.98228475
61Biosynthesis of amino acids_Homo sapiens_hsa012300.95254246
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95137996
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94589002
64Arachidonic acid metabolism_Homo sapiens_hsa005900.94260460
65Mismatch repair_Homo sapiens_hsa034300.90479001
66Folate biosynthesis_Homo sapiens_hsa007900.85365019
67Butanoate metabolism_Homo sapiens_hsa006500.83735017
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82345844
69Huntingtons disease_Homo sapiens_hsa050160.80098726
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79666688
71Olfactory transduction_Homo sapiens_hsa047400.79401065
72Axon guidance_Homo sapiens_hsa043600.78629499
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78538174
74Morphine addiction_Homo sapiens_hsa050320.76510416
75Homologous recombination_Homo sapiens_hsa034400.72609504
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71377730
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70458804
78Selenocompound metabolism_Homo sapiens_hsa004500.70401708
79Fatty acid metabolism_Homo sapiens_hsa012120.70301748
80Nitrogen metabolism_Homo sapiens_hsa009100.69100183
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.68280963
82Wnt signaling pathway_Homo sapiens_hsa043100.67866803
83GABAergic synapse_Homo sapiens_hsa047270.67354849
84N-Glycan biosynthesis_Homo sapiens_hsa005100.67211176
85Pyruvate metabolism_Homo sapiens_hsa006200.66847550
86Vibrio cholerae infection_Homo sapiens_hsa051100.65883328
87Oocyte meiosis_Homo sapiens_hsa041140.65754002
88Basal cell carcinoma_Homo sapiens_hsa052170.63164804
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62376868
90Synaptic vesicle cycle_Homo sapiens_hsa047210.60451676
91Notch signaling pathway_Homo sapiens_hsa043300.60434592
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.59782813
93Ether lipid metabolism_Homo sapiens_hsa005650.59671049
94Arginine and proline metabolism_Homo sapiens_hsa003300.59573984
95Cardiac muscle contraction_Homo sapiens_hsa042600.58190128
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56813843
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56390657
98p53 signaling pathway_Homo sapiens_hsa041150.55828424
99Carbon metabolism_Homo sapiens_hsa012000.53939566
100Pathways in cancer_Homo sapiens_hsa052000.53610041
101FoxO signaling pathway_Homo sapiens_hsa040680.53440599
102Fatty acid elongation_Homo sapiens_hsa000620.52890321
103ABC transporters_Homo sapiens_hsa020100.52785538
104Hippo signaling pathway_Homo sapiens_hsa043900.52357953
105mRNA surveillance pathway_Homo sapiens_hsa030150.52342673
106Caffeine metabolism_Homo sapiens_hsa002320.52067913
107Vitamin B6 metabolism_Homo sapiens_hsa007500.50829038
108Fat digestion and absorption_Homo sapiens_hsa049750.50377877
109Parkinsons disease_Homo sapiens_hsa050120.48823545
110Regulation of autophagy_Homo sapiens_hsa041400.47246084
111Rap1 signaling pathway_Homo sapiens_hsa040150.45045289
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44886923
113Prolactin signaling pathway_Homo sapiens_hsa049170.43446463
114Fatty acid degradation_Homo sapiens_hsa000710.42507781
115Oxidative phosphorylation_Homo sapiens_hsa001900.41102772
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40858562
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.39377422
118Peroxisome_Homo sapiens_hsa041460.39235294
119Prion diseases_Homo sapiens_hsa050200.38778864
120Prostate cancer_Homo sapiens_hsa052150.38231075
121Metabolic pathways_Homo sapiens_hsa011000.38155026
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37902441
123Cholinergic synapse_Homo sapiens_hsa047250.37599543
124Pyrimidine metabolism_Homo sapiens_hsa002400.37481238
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37411374
126ECM-receptor interaction_Homo sapiens_hsa045120.36775126
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36653327
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35423714
129Gap junction_Homo sapiens_hsa045400.35202461
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34575640
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34038958
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31486654
133Circadian entrainment_Homo sapiens_hsa047130.31186892
134Influenza A_Homo sapiens_hsa051640.30356395
135Tight junction_Homo sapiens_hsa045300.30245460
136ErbB signaling pathway_Homo sapiens_hsa040120.29440159
137Cell cycle_Homo sapiens_hsa041100.29291601
138Herpes simplex infection_Homo sapiens_hsa051680.29044928
139TNF signaling pathway_Homo sapiens_hsa046680.28866988
140Dopaminergic synapse_Homo sapiens_hsa047280.28350965
141Graft-versus-host disease_Homo sapiens_hsa053320.28242281
142Phagosome_Homo sapiens_hsa041450.27226490
143Ovarian steroidogenesis_Homo sapiens_hsa049130.27187288
144Endometrial cancer_Homo sapiens_hsa052130.26428783
145Alcoholism_Homo sapiens_hsa050340.25828587
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25607016
147Linoleic acid metabolism_Homo sapiens_hsa005910.24811764
148Purine metabolism_Homo sapiens_hsa002300.24705609
149Melanoma_Homo sapiens_hsa052180.24639344
150Hepatitis C_Homo sapiens_hsa051600.24370478
151RNA polymerase_Homo sapiens_hsa030200.23259788
152Glutamatergic synapse_Homo sapiens_hsa047240.22722469
153Phenylalanine metabolism_Homo sapiens_hsa003600.21460961
154Histidine metabolism_Homo sapiens_hsa003400.21023930
155Colorectal cancer_Homo sapiens_hsa052100.20928120

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