SPACA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.48987607
2spermatid development (GO:0007286)9.23358166
3cilium movement (GO:0003341)8.33967369
4single fertilization (GO:0007338)7.88148663
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.74258805
6regulation of cilium movement (GO:0003352)7.61350913
7male meiosis (GO:0007140)7.42267672
8sperm capacitation (GO:0048240)7.24854509
9piRNA metabolic process (GO:0034587)7.21492824
10synaptonemal complex organization (GO:0070193)7.08009693
11synaptonemal complex assembly (GO:0007130)6.96653768
12fertilization (GO:0009566)6.43581713
13spermatogenesis (GO:0007283)6.02868604
14male gamete generation (GO:0048232)6.00637538
15organic cation transport (GO:0015695)5.95265902
16spermatid nucleus differentiation (GO:0007289)5.71919728
17negative regulation of inclusion body assembly (GO:0090084)5.63276662
18microtubule depolymerization (GO:0007019)5.62821044
19gamete generation (GO:0007276)5.52267650
20ventricular system development (GO:0021591)5.32475404
21calcium ion-dependent exocytosis (GO:0017156)5.25416982
22* cellular process involved in reproduction in multicellular organism (GO:0022412)5.20248189
23germ cell development (GO:0007281)5.17797858
24cell recognition (GO:0008037)5.14263439
25regulation of inclusion body assembly (GO:0090083)4.83035686
26chromosome organization involved in meiosis (GO:0070192)4.80704804
27male meiosis I (GO:0007141)4.71931271
28DNA methylation involved in gamete generation (GO:0043046)4.68403427
29microtubule severing (GO:0051013)4.55182204
30meiotic nuclear division (GO:0007126)4.41866155
31regulation of microtubule-based movement (GO:0060632)4.38645399
32glycerol ether metabolic process (GO:0006662)4.36413761
33multicellular organismal reproductive process (GO:0048609)4.34381341
34monoubiquitinated protein deubiquitination (GO:0035520)4.32891083
35seminiferous tubule development (GO:0072520)4.17968117
36ether metabolic process (GO:0018904)4.02484960
37sexual reproduction (GO:0019953)4.01009241
38protein K11-linked deubiquitination (GO:0035871)3.88842974
39left/right pattern formation (GO:0060972)3.86302580
40single strand break repair (GO:0000012)3.81510092
41genitalia morphogenesis (GO:0035112)3.79409519
42meiosis I (GO:0007127)3.78121297
43chromosome condensation (GO:0030261)3.58327299
44chaperone-mediated protein complex assembly (GO:0051131)3.53633921
45multicellular organismal development (GO:0007275)3.50157180
46protein localization to cilium (GO:0061512)3.46512483
47DNA packaging (GO:0006323)3.45086734
48sequestering of actin monomers (GO:0042989)3.40504048
49centriole assembly (GO:0098534)3.35295829
50meiotic cell cycle (GO:0051321)3.31029569
51protein polyglutamylation (GO:0018095)3.29700614
52amino-acid betaine transport (GO:0015838)3.20332211
53carnitine transport (GO:0015879)3.20332211
54centriole replication (GO:0007099)3.11809983
55carnitine transmembrane transport (GO:1902603)3.09711522
56intraciliary transport (GO:0042073)3.02742079
57microtubule polymerization or depolymerization (GO:0031109)3.01045922
58cilium organization (GO:0044782)2.96462626
59nucleus organization (GO:0006997)2.94688702
60positive regulation of macrophage activation (GO:0043032)2.91768310
61protein refolding (GO:0042026)2.90437971
62polyol catabolic process (GO:0046174)2.88542894
63microtubule-based movement (GO:0007018)2.86254347
64lactate metabolic process (GO:0006089)2.85549434
65cilium assembly (GO:0042384)2.84394667
66alditol metabolic process (GO:0019400)2.83320159
67synapsis (GO:0007129)2.81434619
68regulation of spindle checkpoint (GO:0090231)2.78992544
69meiotic cell cycle process (GO:1903046)2.75419487
70axoneme assembly (GO:0035082)2.75375742
71gene silencing by RNA (GO:0031047)2.74712849
72nucleoside diphosphate phosphorylation (GO:0006165)2.74485224
73nuclear pore complex assembly (GO:0051292)2.72059945
74cilium morphogenesis (GO:0060271)2.70619227
75regulation of centriole replication (GO:0046599)2.70039897
76regulation of cytokine production involved in inflammatory response (GO:1900015)2.68690625
77glycolytic process (GO:0006096)2.67168886
78negative regulation of organelle assembly (GO:1902116)2.66481876
79* cellular component assembly involved in morphogenesis (GO:0010927)2.62595367
80GTP biosynthetic process (GO:0006183)2.57339135
81single-organism membrane fusion (GO:0044801)2.53057068
82peptidyl-threonine dephosphorylation (GO:0035970)2.50203376
83glycerol metabolic process (GO:0006071)2.49987745
84mitotic sister chromatid cohesion (GO:0007064)2.43420097
85interferon-gamma secretion (GO:0072643)2.41000280
86cell wall macromolecule catabolic process (GO:0016998)15.5981972
87cell wall macromolecule metabolic process (GO:0044036)15.5981972
88fusion of sperm to egg plasma membrane (GO:0007342)15.3143720
89sperm motility (GO:0030317)12.6892525
90multicellular organism reproduction (GO:0032504)12.2877878
91sperm-egg recognition (GO:0035036)11.9839658
92plasma membrane fusion (GO:0045026)11.6470207
93cilium or flagellum-dependent cell motility (GO:0001539)11.5828113
94acrosome reaction (GO:0007340)10.8756760
95cell-cell recognition (GO:0009988)10.7671272
96binding of sperm to zona pellucida (GO:0007339)10.5182885
97reproduction (GO:0000003)10.4482999
98* acrosome assembly (GO:0001675)10.3105772
99epithelial cilium movement (GO:0003351)10.1439007
100axonemal dynein complex assembly (GO:0070286)10.0112007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02251662
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.85040617
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94399082
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91612790
5EZH2_22144423_ChIP-Seq_EOC_Human2.88331773
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.56537193
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47370022
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36083243
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28930561
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25747897
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00897700
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5633904
13ZNF274_21170338_ChIP-Seq_K562_Hela1.92330179
14TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.92087446
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.90407048
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89622347
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.88852534
18RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.82710760
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77653928
20GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.74640325
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74271125
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.73913369
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68223132
24VDR_22108803_ChIP-Seq_LS180_Human1.67715582
25STAT1_17558387_ChIP-Seq_HELA_Human1.66690202
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.63980119
27KDM2B_26808549_Chip-Seq_REH_Human1.63267024
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63266774
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.59356339
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.55177785
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52275971
32GATA3_21867929_ChIP-Seq_CD8_Mouse1.51067348
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50696557
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47929213
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47177240
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44133674
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41929341
38FLI1_21867929_ChIP-Seq_TH2_Mouse1.41893290
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39537615
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.38792301
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35531585
42* CBP_20019798_ChIP-Seq_JUKART_Human1.33536353
43* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33536353
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30696712
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.29986806
46P53_21459846_ChIP-Seq_SAOS-2_Human1.28738410
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24443475
48OCT4_18555785_Chip-Seq_ESCs_Mouse1.23229515
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23181015
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21574820
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.21065114
52* NANOG_18555785_Chip-Seq_ESCs_Mouse1.21027664
53P53_22387025_ChIP-Seq_ESCs_Mouse1.19314682
54GF1_26923725_Chip-Seq_HPCs_Mouse1.18335839
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.16953117
56SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16759243
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16593164
58P300_18555785_Chip-Seq_ESCs_Mouse1.16299126
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15771402
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15595827
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13799892
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.13465129
63OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12496528
64ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11552880
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11489499
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11076519
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11040337
68CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10074145
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08123901
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07926458
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07926458
72SPI1_26923725_Chip-Seq_HPCs_Mouse1.06720419
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05677870
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04945719
75* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03798327
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.03442910
77LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02752112
78REST_21632747_ChIP-Seq_MESCs_Mouse1.02580209
79* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99942140
80SOX2_18555785_Chip-Seq_ESCs_Mouse0.99927071
81CTCF_18555785_Chip-Seq_ESCs_Mouse0.99761676
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99632377
83ESET_19884257_ChIP-Seq_ESCs_Mouse0.99298815
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98820232
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97376116
86ERG_20517297_ChIP-Seq_VCAP_Human0.97016298
87PU1_27457419_Chip-Seq_LIVER_Mouse0.96628864
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96360260
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95402877
90RARA_24833708_ChIP-Seq_LIVER_Mouse0.95292795
91GF1B_26923725_Chip-Seq_HPCs_Mouse0.95022380
92TAF15_26573619_Chip-Seq_HEK293_Human0.94904103
93SOX9_26525672_Chip-Seq_HEART_Mouse0.93764906
94SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92646949
95FLI1_21867929_ChIP-Seq_CD8_Mouse0.91644431
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91295005
97RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90263720
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.89153939
99NMYC_18555785_Chip-Seq_ESCs_Mouse0.87985711
100RNF2_27304074_Chip-Seq_NSC_Mouse0.87259144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08237319
2MP0001929_abnormal_gametogenesis5.59846025
3MP0008877_abnormal_DNA_methylation4.37212813
4MP0002210_abnormal_sex_determination3.62001236
5MP0002161_abnormal_fertility/fecundity3.26286189
6MP0001145_abnormal_male_reproductive3.09378596
7MP0002653_abnormal_ependyma_morphology2.81210019
8MP0000653_abnormal_sex_gland2.69239646
9MP0005670_abnormal_white_adipose2.61505724
10MP0005410_abnormal_fertilization15.9528411
11MP0002160_abnormal_reproductive_system1.85076262
12MP0005623_abnormal_meninges_morphology1.82340305
13MP0003646_muscle_fatigue1.69941103
14MP0002282_abnormal_trachea_morphology1.68213290
15MP0004233_abnormal_muscle_weight1.63994167
16MP0008058_abnormal_DNA_repair1.28417956
17MP0001765_abnormal_ion_homeostasis1.07381963
18MP0001984_abnormal_olfaction0.92934638
19MP0009046_muscle_twitch0.91499472
20MP0005647_abnormal_sex_gland0.91342914
21MP0005389_reproductive_system_phenotype0.90325597
22MP0010094_abnormal_chromosome_stability0.82581399
23MP0008995_early_reproductive_senescence0.73442704
24MP0002234_abnormal_pharynx_morphology0.66636213
25MP0005666_abnormal_adipose_tissue0.64988482
26MP0000358_abnormal_cell_content/0.58936362
27MP0002928_abnormal_bile_duct0.58903368
28MP0008057_abnormal_DNA_replication0.56104142
29MP0004134_abnormal_chest_morphology0.56016762
30MP0002102_abnormal_ear_morphology0.55159673
31MP0005636_abnormal_mineral_homeostasis0.54648972
32MP0005397_hematopoietic_system_phenotyp0.54478712
33MP0001545_abnormal_hematopoietic_system0.54478712
34MP0002971_abnormal_brown_adipose0.53942338
35MP0003115_abnormal_respiratory_system0.53519502
36MP0005503_abnormal_tendon_morphology0.53241722
37MP0009115_abnormal_fat_cell0.51637318
38MP0003699_abnormal_female_reproductive0.49842369
39MP0006036_abnormal_mitochondrial_physio0.48384358
40MP0008007_abnormal_cellular_replicative0.48370467
41MP0003011_delayed_dark_adaptation0.48306393
42MP0009697_abnormal_copulation0.45483500
43MP0003950_abnormal_plasma_membrane0.45133335
44MP0002269_muscular_atrophy0.44473994
45MP0004808_abnormal_hematopoietic_stem0.43024078
46MP0003878_abnormal_ear_physiology0.42187159
47MP0005377_hearing/vestibular/ear_phenot0.42187159
48MP0001764_abnormal_homeostasis0.41701935
49MP0001324_abnormal_eye_pigmentation0.41674030
50MP0001119_abnormal_female_reproductive0.41028858
51MP0001293_anophthalmia0.40087384
52MP0005174_abnormal_tail_pigmentation0.39357297
53MP0001270_distended_abdomen0.39271238
54MP0004036_abnormal_muscle_relaxation0.37445537
55MP0002405_respiratory_system_inflammati0.37097763
56MP0003786_premature_aging0.36545023
57MP0009278_abnormal_bone_marrow0.35958964
58MP0010307_abnormal_tumor_latency0.33618053
59MP0002909_abnormal_adrenal_gland0.33480142
60MP0005275_abnormal_skin_tensile0.31435968
61MP0004019_abnormal_vitamin_homeostasis0.30141488
62MP0009250_abnormal_appendicular_skeleto0.29185725
63MP0002163_abnormal_gland_morphology0.29044416
64MP0003111_abnormal_nucleus_morphology0.28430593
65MP0000313_abnormal_cell_death0.26449132
66MP0000685_abnormal_immune_system0.26330882
67MP0000751_myopathy0.25800525
68MP0004130_abnormal_muscle_cell0.24243757
69MP0005253_abnormal_eye_physiology0.24103422
70MP0002970_abnormal_white_adipose0.23733848
71MP0003633_abnormal_nervous_system0.23302848
72MP0005551_abnormal_eye_electrophysiolog0.22882007
73MP0003959_abnormal_lean_body0.20996491
74MP0001730_embryonic_growth_arrest0.20919932
75MP0004133_heterotaxia0.20915354
76MP0005375_adipose_tissue_phenotype0.20779712
77MP0002132_abnormal_respiratory_system0.20420356
78MP0005391_vision/eye_phenotype0.20331159
79MP0006035_abnormal_mitochondrial_morpho0.20194018
80MP0005319_abnormal_enzyme/_coenzyme0.19648191
81MP0003763_abnormal_thymus_physiology0.19632615
82MP0003787_abnormal_imprinting0.19509801
83MP0005535_abnormal_body_temperature0.19004152
84MP0002084_abnormal_developmental_patter0.18440105
85MP0003948_abnormal_gas_homeostasis0.17272922
86MP0002109_abnormal_limb_morphology0.16482802
87MP0002693_abnormal_pancreas_physiology0.16398633
88MP0002933_joint_inflammation0.16189169
89MP0002115_abnormal_skeleton_extremities0.16062612
90MP0002108_abnormal_muscle_morphology0.15813640
91MP0000703_abnormal_thymus_morphology0.14727533
92MP0002398_abnormal_bone_marrow0.14340018
93MP0000569_abnormal_digit_pigmentation0.14220129
94MP0003942_abnormal_urinary_system0.13742818
95MP0004197_abnormal_fetal_growth/weight/0.12992776
96MP0001697_abnormal_embryo_size0.12160693
97MP0000427_abnormal_hair_cycle0.12023841
98MP0002169_no_abnormal_phenotype0.11885686
99MP0005379_endocrine/exocrine_gland_phen0.11842542
100MP0002873_normal_phenotype0.11668768

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.18869845
2Abnormal respiratory motile cilium morphology (HP:0005938)9.01226843
3Abnormal respiratory epithelium morphology (HP:0012253)9.01226843
4Rhinitis (HP:0012384)7.78343413
5Abnormal ciliary motility (HP:0012262)7.48520853
6Chronic bronchitis (HP:0004469)7.36522459
7Nasal polyposis (HP:0100582)6.69759102
8Infertility (HP:0000789)6.13701034
9Abnormality of the nasal mucosa (HP:0000433)5.58025741
10Bronchitis (HP:0012387)4.76819026
11Bronchiectasis (HP:0002110)4.60533191
12Nephronophthisis (HP:0000090)4.13181557
13Male infertility (HP:0003251)3.76367544
14Recurrent sinusitis (HP:0011108)3.70497910
15Abnormal spermatogenesis (HP:0008669)3.47827110
16Recurrent otitis media (HP:0000403)3.40928640
17Abnormality of the renal medulla (HP:0100957)3.11468115
18Medial flaring of the eyebrow (HP:0010747)3.05207806
19Recurrent bronchitis (HP:0002837)3.03683404
20Tubulointerstitial nephritis (HP:0001970)2.70388215
21Azoospermia (HP:0000027)2.62851175
22Abnormality of midbrain morphology (HP:0002418)2.61331804
23Molar tooth sign on MRI (HP:0002419)2.61331804
24Tubular atrophy (HP:0000092)2.51305474
25Tubulointerstitial abnormality (HP:0001969)2.28416462
26Impulsivity (HP:0100710)2.15059289
27Gonadotropin excess (HP:0000837)2.12959830
28Chronic sinusitis (HP:0011109)2.06345748
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2709755
30Absent/shortened dynein arms (HP:0200106)12.9741103
31Dynein arm defect of respiratory motile cilia (HP:0012255)12.9741103
32Congenital primary aphakia (HP:0007707)1.97972474
33Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95098048
34Gait imbalance (HP:0002141)1.95063982
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85337780
36Absent epiphyses (HP:0010577)1.85337780
37Postaxial foot polydactyly (HP:0001830)1.85071082
38Abnormal gallbladder physiology (HP:0012438)1.83782451
39Cholecystitis (HP:0001082)1.83782451
40Fibular hypoplasia (HP:0003038)1.82729409
41Absent frontal sinuses (HP:0002688)1.82557740
42Tongue fasciculations (HP:0001308)1.82054916
43Tubulointerstitial fibrosis (HP:0005576)1.79490112
44Short ribs (HP:0000773)1.76383675
45Abnormality of the renal cortex (HP:0011035)1.75463205
46Stage 5 chronic kidney disease (HP:0003774)1.69810500
47Nephrogenic diabetes insipidus (HP:0009806)1.69599009
48Heterotopia (HP:0002282)1.68541165
49Congenital hepatic fibrosis (HP:0002612)1.66780838
50Muscle fibrillation (HP:0010546)1.66259985
51Aplasia/Hypoplasia of the lens (HP:0008063)1.58401760
52Abnormal drinking behavior (HP:0030082)1.57089592
53Polydipsia (HP:0001959)1.57089592
54Postaxial hand polydactyly (HP:0001162)1.56534377
55Short femoral neck (HP:0100864)1.54675930
56Abnormality of saccadic eye movements (HP:0000570)1.54212985
57Abnormality of the dental root (HP:0006486)1.52044993
58Taurodontia (HP:0000679)1.52044993
59Abnormality of permanent molar morphology (HP:0011071)1.52044993
60Microglossia (HP:0000171)1.50697920
61Abnormality of renal excretion (HP:0011036)1.50434350
62Cerebellar dysplasia (HP:0007033)1.49655797
63Asymmetric septal hypertrophy (HP:0001670)1.49315607
64Dyschromatopsia (HP:0007641)1.48509197
65Poor coordination (HP:0002370)1.47701831
66Abnormality of dentin (HP:0010299)1.47419196
67Oculomotor apraxia (HP:0000657)1.46936549
68Abnormality of the lower motor neuron (HP:0002366)1.45853143
69Bile duct proliferation (HP:0001408)1.45298583
70Abnormal biliary tract physiology (HP:0012439)1.45298583
71Abnormality of molar morphology (HP:0011070)1.44658703
72Abnormality of molar (HP:0011077)1.44658703
73Pancreatic fibrosis (HP:0100732)1.42069044
74Renal dysplasia (HP:0000110)1.39791088
75Genital tract atresia (HP:0001827)1.38353337
76Bell-shaped thorax (HP:0001591)1.38296417
77Vaginal atresia (HP:0000148)1.38072751
78Spastic tetraparesis (HP:0001285)1.38026700
79Decreased central vision (HP:0007663)1.37124340
80Abnormality of the dental pulp (HP:0006479)1.36869435
81Abnormality of ocular smooth pursuit (HP:0000617)1.36743064
82Facial cleft (HP:0002006)1.35471825
83Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.35185126
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.34885949
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.34298293
86Short thorax (HP:0010306)1.33822150
87Type II lissencephaly (HP:0007260)1.33776305
88Supernumerary spleens (HP:0009799)1.30548435
89Cystic liver disease (HP:0006706)1.29089812
90J-shaped sella turcica (HP:0002680)1.27235506
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.25971045
92Retinal dysplasia (HP:0007973)1.25324669
93Chronic otitis media (HP:0000389)1.25288361
94Easy fatigability (HP:0003388)1.24823205
95Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24588534
96True hermaphroditism (HP:0010459)1.23264614
97Deformed sella turcica (HP:0002681)1.22789565
98Amyotrophic lateral sclerosis (HP:0007354)1.21525755
99Flattened epiphyses (HP:0003071)1.19812498
100Irregular epiphyses (HP:0010582)1.19560076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.09738871
2PDK39.09738871
3PDK25.87810528
4TESK15.12207701
5PRKD33.71938765
6ICK3.25164991
7PTK2B2.25155340
8WNK41.95977760
9STK391.80981848
10PNCK1.69886261
11NEK21.55645923
12STK381.54683599
13DYRK1B1.11202975
14PDK11.09881460
15IRAK11.04663593
16WEE10.98754629
17BRSK20.94592471
18LMTK20.83969519
19STK30.76160255
20TYRO30.75102004
21PASK0.75075406
22PLK40.74032365
23WNK10.73382962
24STK38L0.70736445
25MAP2K60.65774733
26DYRK30.62942327
27CHEK20.61477879
28EEF2K0.61059666
29MAPK150.60494781
30CSF1R0.51525928
31CCNB10.49266999
32CDK120.47975510
33PDPK10.46584053
34TTK0.43366529
35IRAK20.43266217
36CAMK1G0.41830777
37TESK20.41378888
38CHEK10.40735919
39RIPK10.39006754
40MARK30.37433446
41ZAP700.34529924
42MAP3K100.33083013
43ATR0.32659241
44BRSK10.32221821
45ATM0.31189010
46CDC70.29116379
47KIT0.28870459
48STK100.28728555
49PAK20.28187606
50PRKG20.27924607
51PAK10.27288737
52NEK60.25447162
53MTOR0.24738993
54PINK10.24701521
55MUSK0.23853143
56MAP4K10.21023747
57MARK20.20969309
58RIPK40.19749518
59PLK10.16406466
60PRKAA10.16345784
61CDK40.15803790
62RPS6KB10.14060804
63TGFBR20.13814842
64PAK40.11927229
65CDK60.11867546
66PRKCG0.11729733
67BTK0.11174290
68PRKCQ0.10948981
69MAP3K30.09885482
70PDGFRB0.09581075
71TRIB30.08677517
72FLT30.08389161
73MAPKAPK50.08125052
74CAMKK10.07819626
75PIM10.06560121
76EGFR0.05702583
77CSNK2A10.05227972
78PRKG10.04569894
79CDK20.04468647
80STK240.04266554
81DDR20.04248758
82PRKACG0.03792768
83GSK3B0.03626500
84NLK0.03563127
85MAP3K50.03539934
86RPS6KA10.03283661
87EPHB10.03280464
88CSNK2A20.03073198
89YES10.02788269
90STK110.02740978
91CSNK1D0.02218270
92PKN10.01980813
93CDK10.01935315
94MAPK80.01928627
95LCK0.01722501
96PRKDC0.00453817
97SYK0.00399945
98MAPK40.00133651
99PRKCD-0.0219840
100NTRK2-0.0061495

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.26140849
2Pyruvate metabolism_Homo sapiens_hsa006203.86631290
3Vitamin B6 metabolism_Homo sapiens_hsa007503.77436244
4Fatty acid biosynthesis_Homo sapiens_hsa000613.58361092
5Propanoate metabolism_Homo sapiens_hsa006403.08268672
6Basal transcription factors_Homo sapiens_hsa030222.91440933
7Glucagon signaling pathway_Homo sapiens_hsa049222.65322297
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.64679668
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.59049691
10Selenocompound metabolism_Homo sapiens_hsa004502.47138742
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40901441
12Linoleic acid metabolism_Homo sapiens_hsa005912.38521908
13Pentose phosphate pathway_Homo sapiens_hsa000302.29243301
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17080062
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.14848509
16Glycerolipid metabolism_Homo sapiens_hsa005612.13154091
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99657278
18Oocyte meiosis_Homo sapiens_hsa041141.96688278
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90484233
20PPAR signaling pathway_Homo sapiens_hsa033201.82784764
21Fanconi anemia pathway_Homo sapiens_hsa034601.70775388
22Antigen processing and presentation_Homo sapiens_hsa046121.54295033
23Dorso-ventral axis formation_Homo sapiens_hsa043201.50658849
24Carbon metabolism_Homo sapiens_hsa012001.42479075
25Huntingtons disease_Homo sapiens_hsa050161.40883125
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.38951560
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37947061
28Amphetamine addiction_Homo sapiens_hsa050311.33167348
29mRNA surveillance pathway_Homo sapiens_hsa030151.24688804
30Purine metabolism_Homo sapiens_hsa002301.16421242
31Fructose and mannose metabolism_Homo sapiens_hsa000511.16274700
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15546332
33RNA transport_Homo sapiens_hsa030131.14834170
34Cardiac muscle contraction_Homo sapiens_hsa042601.11685995
35Mineral absorption_Homo sapiens_hsa049781.09705185
36Fat digestion and absorption_Homo sapiens_hsa049751.09407909
37Renin secretion_Homo sapiens_hsa049241.06785729
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.04079271
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01970766
40Fatty acid degradation_Homo sapiens_hsa000710.96484079
41Renin-angiotensin system_Homo sapiens_hsa046140.95481314
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94508475
43Protein digestion and absorption_Homo sapiens_hsa049740.93643457
44Ether lipid metabolism_Homo sapiens_hsa005650.91918395
45Glutathione metabolism_Homo sapiens_hsa004800.91706274
46Fatty acid metabolism_Homo sapiens_hsa012120.91124719
47N-Glycan biosynthesis_Homo sapiens_hsa005100.87723486
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86251114
49Biosynthesis of amino acids_Homo sapiens_hsa012300.85433541
50Systemic lupus erythematosus_Homo sapiens_hsa053220.84813819
51Legionellosis_Homo sapiens_hsa051340.79225374
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75735432
53Inositol phosphate metabolism_Homo sapiens_hsa005620.73867523
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67938036
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.66589238
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63212303
57Thyroid hormone synthesis_Homo sapiens_hsa049180.62630044
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.60849303
59Estrogen signaling pathway_Homo sapiens_hsa049150.60462789
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58859404
61Arachidonic acid metabolism_Homo sapiens_hsa005900.58110385
62Collecting duct acid secretion_Homo sapiens_hsa049660.57517506
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57323725
64ABC transporters_Homo sapiens_hsa020100.57062996
65Insulin secretion_Homo sapiens_hsa049110.55532803
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54519755
67Chemical carcinogenesis_Homo sapiens_hsa052040.51403978
68Hedgehog signaling pathway_Homo sapiens_hsa043400.49972417
69Calcium signaling pathway_Homo sapiens_hsa040200.49190890
70AMPK signaling pathway_Homo sapiens_hsa041520.46804948
71Bile secretion_Homo sapiens_hsa049760.46634149
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46118996
73Endocytosis_Homo sapiens_hsa041440.43880827
74Metabolic pathways_Homo sapiens_hsa011000.42322111
75Long-term potentiation_Homo sapiens_hsa047200.41668408
76B cell receptor signaling pathway_Homo sapiens_hsa046620.38404515
77Non-homologous end-joining_Homo sapiens_hsa034500.37948800
78Pyrimidine metabolism_Homo sapiens_hsa002400.35791407
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35518894
80Alcoholism_Homo sapiens_hsa050340.32399098
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31655065
82Pancreatic secretion_Homo sapiens_hsa049720.31630622
83Sulfur metabolism_Homo sapiens_hsa009200.30404123
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29776167
85Taste transduction_Homo sapiens_hsa047420.29230094
86cAMP signaling pathway_Homo sapiens_hsa040240.28996963
87Viral carcinogenesis_Homo sapiens_hsa052030.28553680
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25080301
89T cell receptor signaling pathway_Homo sapiens_hsa046600.24613555
90Cell cycle_Homo sapiens_hsa041100.24016412
91Salivary secretion_Homo sapiens_hsa049700.22117972
92Gastric acid secretion_Homo sapiens_hsa049710.21351305
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21124537
94Homologous recombination_Homo sapiens_hsa034400.20091145
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19461097
96VEGF signaling pathway_Homo sapiens_hsa043700.16996033
97Primary immunodeficiency_Homo sapiens_hsa053400.16979377
98Cocaine addiction_Homo sapiens_hsa050300.16425811
99Circadian entrainment_Homo sapiens_hsa047130.15810671
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15236146

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »