SPACA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.83745510
2epithelial cilium movement (GO:0003351)9.80217342
3spermatid development (GO:0007286)9.80082259
4axonemal dynein complex assembly (GO:0070286)9.76551144
5cilium or flagellum-dependent cell motility (GO:0001539)9.48113791
6motile cilium assembly (GO:0044458)9.39859529
7regulation of cilium movement (GO:0003352)8.27351240
8response to pheromone (GO:0019236)8.20910501
9cilium movement (GO:0003341)8.06936906
10sperm capacitation (GO:0048240)7.59450124
11single fertilization (GO:0007338)7.50879280
12rRNA methylation (GO:0031167)7.49370242
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.33034528
14synaptonemal complex organization (GO:0070193)7.30232287
15male meiosis (GO:0007140)7.29833600
16synaptonemal complex assembly (GO:0007130)7.28042851
17piRNA metabolic process (GO:0034587)6.77517266
18negative regulation of inclusion body assembly (GO:0090084)6.74802953
19organic cation transport (GO:0015695)6.71996590
20spermatogenesis (GO:0007283)6.70697637
21male gamete generation (GO:0048232)6.68217139
22rRNA modification (GO:0000154)6.60356187
23fertilization (GO:0009566)6.34131165
24gamete generation (GO:0007276)6.14305966
25microtubule depolymerization (GO:0007019)6.14185899
26spermatid nucleus differentiation (GO:0007289)5.86399219
27regulation of inclusion body assembly (GO:0090083)5.76963724
28calcium ion-dependent exocytosis (GO:0017156)5.70822738
29establishment of protein localization to Golgi (GO:0072600)5.66552862
30protein targeting to Golgi (GO:0000042)5.60204811
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.56697032
32germ cell development (GO:0007281)5.45679488
33ventricular system development (GO:0021591)5.26016222
34retrograde transport, vesicle recycling within Golgi (GO:0000301)5.22313516
35microtubule severing (GO:0051013)5.19487776
36chromosome condensation (GO:0030261)5.18438492
37phosphatidylethanolamine biosynthetic process (GO:0006646)5.07223907
38* cell recognition (GO:0008037)5.03834211
39cellular ketone body metabolic process (GO:0046950)4.95572538
40DNA packaging (GO:0006323)4.95379527
41chromosome organization involved in meiosis (GO:0070192)4.93189835
42regulation of microtubule-based movement (GO:0060632)4.85938440
43multicellular organismal reproductive process (GO:0048609)4.82202901
44phosphatidylethanolamine metabolic process (GO:0046337)4.80100010
45glycerol ether metabolic process (GO:0006662)4.70081912
46male meiosis I (GO:0007141)4.66393123
47seminiferous tubule development (GO:0072520)4.61412551
48ketone body metabolic process (GO:1902224)4.59243373
49protein localization to Golgi apparatus (GO:0034067)4.57193678
50DNA methylation involved in gamete generation (GO:0043046)4.42282461
51microtubule nucleation (GO:0007020)4.42187736
52ether metabolic process (GO:0018904)4.34431720
53meiotic nuclear division (GO:0007126)4.33371262
54sexual reproduction (GO:0019953)4.31569773
55single strand break repair (GO:0000012)4.21454313
56cerebral cortex neuron differentiation (GO:0021895)4.11101565
57left/right pattern formation (GO:0060972)4.09287274
58sequestering of actin monomers (GO:0042989)4.07938282
59chaperone-mediated protein complex assembly (GO:0051131)3.99188371
60protein polyglutamylation (GO:0018095)3.91691389
61multicellular organismal development (GO:0007275)3.87653907
62regulation of Rab GTPase activity (GO:0032313)3.85505460
63positive regulation of Rab GTPase activity (GO:0032851)3.85505460
64regulation of MHC class II biosynthetic process (GO:0045346)3.72861886
65glomerular visceral epithelial cell development (GO:0072015)3.72665780
66meiosis I (GO:0007127)3.71642586
67regulation of centriole replication (GO:0046599)3.63003891
68monoubiquitinated protein deubiquitination (GO:0035520)3.61622295
69genitalia morphogenesis (GO:0035112)3.59180633
70protein K11-linked deubiquitination (GO:0035871)3.59137200
71negative regulation of astrocyte differentiation (GO:0048712)3.44183764
72regulation of spindle checkpoint (GO:0090231)3.39907940
73myelin assembly (GO:0032288)3.39644070
74glomerular epithelial cell development (GO:0072310)3.38310379
75amino-acid betaine transport (GO:0015838)3.31631076
76carnitine transport (GO:0015879)3.31631076
77protein localization to cilium (GO:0061512)3.31016685
78regulation of meiosis I (GO:0060631)3.19693166
79meiotic cell cycle (GO:0051321)3.19636373
80carnitine transmembrane transport (GO:1902603)3.16832636
81microtubule polymerization or depolymerization (GO:0031109)3.14988566
82nucleus organization (GO:0006997)3.12085216
83interferon-gamma secretion (GO:0072643)3.09738636
84protein refolding (GO:0042026)3.08268917
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07251122
86regulation of transcription involved in cell fate commitment (GO:0060850)3.04769798
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.99821060
88retinal rod cell development (GO:0046548)2.92698279
89glycolytic process (GO:0006096)2.89731283
90axon ensheathment in central nervous system (GO:0032291)2.88484954
91central nervous system myelination (GO:0022010)2.88484954
92RNA localization (GO:0006403)2.87290560
93synapsis (GO:0007129)2.86401529
94brain morphogenesis (GO:0048854)2.86379924
95cilium organization (GO:0044782)2.85960937
96regulation of protein kinase A signaling (GO:0010738)2.85831479
97multicellular organismal movement (GO:0050879)2.84790044
98musculoskeletal movement (GO:0050881)2.84790044
99intraciliary transport (GO:0042073)2.83215513
100nonmotile primary cilium assembly (GO:0035058)2.82955418
101detection of light stimulus involved in sensory perception (GO:0050962)2.81848645
102detection of light stimulus involved in visual perception (GO:0050908)2.81848645
103axoneme assembly (GO:0035082)2.81055642
104mitochondrial fission (GO:0000266)2.79852016
105nucleoside diphosphate phosphorylation (GO:0006165)2.79441928
106meiotic cell cycle process (GO:1903046)2.79347162
107microtubule-based movement (GO:0007018)2.79334910
108polyol catabolic process (GO:0046174)2.79078772
109somite rostral/caudal axis specification (GO:0032525)2.78285762
110cellular component assembly involved in morphogenesis (GO:0010927)2.78195680
111intra-Golgi vesicle-mediated transport (GO:0006891)2.76256102
112regulation of interleukin-13 production (GO:0032656)2.74024220
113negative regulation of organelle assembly (GO:1902116)2.73304944
114cilium assembly (GO:0042384)2.72871976
115polyamine biosynthetic process (GO:0006596)2.72497924
116mitotic sister chromatid cohesion (GO:0007064)2.72336139
117RNA destabilization (GO:0050779)2.72049082
118cell differentiation involved in metanephros development (GO:0072202)2.71692211
119alanine transport (GO:0032328)2.71158778
120photoreceptor cell maintenance (GO:0045494)2.70615052
121alditol metabolic process (GO:0019400)2.70314177
122cilium morphogenesis (GO:0060271)2.69971452
123regulation of telomere maintenance (GO:0032204)2.68543479
124centriole assembly (GO:0098534)2.65706064
125urinary tract smooth muscle contraction (GO:0014848)2.65524884
126peptidyl-glutamic acid modification (GO:0018200)2.64962233
127chromatin silencing (GO:0006342)2.63353031
128regulation of timing of cell differentiation (GO:0048505)2.61073114
129regulation of cilium assembly (GO:1902017)2.55252977
130nucleosome disassembly (GO:0006337)2.51056038
131protein-DNA complex disassembly (GO:0032986)2.51056038
132lactate metabolic process (GO:0006089)2.50568201
133GTP biosynthetic process (GO:0006183)2.48954648
134centriole replication (GO:0007099)2.40533700
135fusion of sperm to egg plasma membrane (GO:0007342)13.8214981
136sperm motility (GO:0030317)13.6608661
137acrosome assembly (GO:0001675)12.7183255
138* cell wall macromolecule catabolic process (GO:0016998)12.3743586
139* cell wall macromolecule metabolic process (GO:0044036)12.3743586
140acrosome reaction (GO:0007340)12.2570700
141* sperm-egg recognition (GO:0035036)11.7202257
142multicellular organism reproduction (GO:0032504)11.4151000
143binding of sperm to zona pellucida (GO:0007339)10.9927499
144plasma membrane fusion (GO:0045026)10.5315796
145* cell-cell recognition (GO:0009988)10.4773274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.61498592
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.29856477
3EZH2_22144423_ChIP-Seq_EOC_Human3.70906013
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25203461
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.96533298
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93040947
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72859636
8FUS_26573619_Chip-Seq_HEK293_Human2.63121046
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.57646693
10GBX2_23144817_ChIP-Seq_PC3_Human2.53311461
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.29045391
12VDR_22108803_ChIP-Seq_LS180_Human2.24504639
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.13869430
14ZNF274_21170338_ChIP-Seq_K562_Hela2.07144252
15P300_19829295_ChIP-Seq_ESCs_Human2.05254321
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04768403
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.04233732
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02048222
19TAF15_26573619_Chip-Seq_HEK293_Human1.99511865
20ER_23166858_ChIP-Seq_MCF-7_Human1.97512787
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.95830950
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.92432027
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82282401
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81962860
25* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81188962
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79103485
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77927926
28AR_21572438_ChIP-Seq_LNCaP_Human1.77086546
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76924042
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76543598
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73603524
32* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73318197
33* AR_25329375_ChIP-Seq_VCAP_Human1.72310675
34SMAD4_21799915_ChIP-Seq_A2780_Human1.69244938
35STAT1_17558387_ChIP-Seq_HELA_Human1.68311923
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.67576459
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65440388
38STAT3_23295773_ChIP-Seq_U87_Human1.59651532
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59074567
40* GATA3_21867929_ChIP-Seq_CD8_Mouse1.58200586
41* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57621007
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.57333165
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54477659
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.54412175
45* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54403447
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53960358
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53384322
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.52080372
49KDM2B_26808549_Chip-Seq_REH_Human1.50006780
50* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49678254
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48132691
52RUNX2_22187159_ChIP-Seq_PCA_Human1.46611970
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44846997
54* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44297961
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43258625
56TCF4_23295773_ChIP-Seq_U87_Human1.41809199
57NANOG_19829295_ChIP-Seq_ESCs_Human1.41201817
58SOX2_19829295_ChIP-Seq_ESCs_Human1.41201817
59* TAL1_26923725_Chip-Seq_HPCs_Mouse1.40754827
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40192526
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39077378
62MYC_19829295_ChIP-Seq_ESCs_Human1.37712117
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37457557
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.37172237
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.35879418
66DROSHA_22980978_ChIP-Seq_HELA_Human1.35307286
67* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34804034
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34382978
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34206790
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32269134
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31421930
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.30851362
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.30846497
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30761146
75TCF4_22108803_ChIP-Seq_LS180_Human1.30643770
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.29819199
77* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29697839
78* CBP_20019798_ChIP-Seq_JUKART_Human1.29697839
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.29079222
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28330321
81* FLI1_21867929_ChIP-Seq_TH2_Mouse1.26842743
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26781955
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26492802
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26167484
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25870102
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25301832
87CDX2_22108803_ChIP-Seq_LS180_Human1.24601195
88ERA_21632823_ChIP-Seq_H3396_Human1.24595179
89* P53_21459846_ChIP-Seq_SAOS-2_Human1.24576815
90TP53_18474530_ChIP-ChIP_U2OS_Human1.24480208
91GF1_26923725_Chip-Seq_HPCs_Mouse1.23884068
92* REST_21632747_ChIP-Seq_MESCs_Mouse1.22485448
93TAF2_19829295_ChIP-Seq_ESCs_Human1.21663404
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19849883
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18721152
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18310923
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18075316
98NANOG_20526341_ChIP-Seq_ESCs_Human1.17640311
99RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17197167
100SPI1_26923725_Chip-Seq_HPCs_Mouse1.16802490
101CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16633244
102NCOR_22424771_ChIP-Seq_293T_Human1.16301144
103ETV1_20927104_ChIP-Seq_GIST48_Human1.16172383
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15644222
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15326704
106TP53_22573176_ChIP-Seq_HFKS_Human1.14303221
107RBPJ_21746931_ChIP-Seq_IB4_Human1.13658110
108CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13607530
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13264723
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.13264723
111NFYB_21822215_ChIP-Seq_K562_Human1.13061044
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12817828
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.12739921
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.12565503
115* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11630799
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.11490258
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11462445
118* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11344870
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11305463
120SMRT_27268052_Chip-Seq_Bcells_Human1.10317533
121HOXB7_26014856_ChIP-Seq_BT474_Human1.09898714
122RAC3_21632823_ChIP-Seq_H3396_Human1.09172113
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.09130665
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08679990
125BCAT_22108803_ChIP-Seq_LS180_Human1.08616887
126* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08166232
127HNFA_21074721_ChIP-Seq_CACO-2_Human1.08007120
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07875975
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.07550901
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07525395
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07525395
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07484255
133PHF8_20622853_ChIP-Seq_HELA_Human1.05759354
134TBL1_22424771_ChIP-Seq_293T_Human1.05556373
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05491892
136NFYA_21822215_ChIP-Seq_K562_Human1.04816626
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04229070
138* RARA_24833708_ChIP-Seq_LIVER_Mouse1.03988087
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03616569
140P53_22387025_ChIP-Seq_ESCs_Mouse1.03418586
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03342573
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03244919
143RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02781648
144OCT4_20526341_ChIP-Seq_ESCs_Human1.02561985
145* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02329964
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.02128228
147TET1_21451524_ChIP-Seq_MESCs_Mouse1.02040760
148ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01730429
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.99938981
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.99838954
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.99800393
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99305509
153* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98574046
154ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97959824
155P300_18555785_Chip-Seq_ESCs_Mouse0.97884395
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97572419
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96855084
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96457506
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95870947
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.95794094
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.94401993
162RNF2_27304074_Chip-Seq_NSC_Mouse0.93323740
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93114375
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92528869
165SOX9_26525672_Chip-Seq_HEART_Mouse0.92388655
166SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92301971
167JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92159434
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91256804
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.89978341
170* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89962710
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89873016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06985790
2MP0001929_abnormal_gametogenesis5.55882755
3MP0008877_abnormal_DNA_methylation3.99851588
4MP0002210_abnormal_sex_determination3.38663553
5MP0002161_abnormal_fertility/fecundity3.28002413
6MP0001145_abnormal_male_reproductive2.93175608
7MP0005670_abnormal_white_adipose2.62853652
8MP0001348_abnormal_lacrimal_gland2.59450659
9MP0002653_abnormal_ependyma_morphology2.57087445
10MP0000653_abnormal_sex_gland2.54353022
11MP0003718_maternal_effect2.46504126
12MP0003136_yellow_coat_color2.45205243
13MP0003880_abnormal_central_pattern2.43560435
14MP0002735_abnormal_chemical_nociception2.24162162
15MP0001485_abnormal_pinna_reflex2.09647091
16MP0004742_abnormal_vestibular_system2.00581211
17MP0005410_abnormal_fertilization16.5119410
18MP0005310_abnormal_salivary_gland1.82979853
19MP0002160_abnormal_reproductive_system1.82122315
20MP0004885_abnormal_endolymph1.81352955
21MP0001486_abnormal_startle_reflex1.81171383
22MP0004233_abnormal_muscle_weight1.79551186
23MP0003646_muscle_fatigue1.71752414
24MP0005367_renal/urinary_system_phenotyp1.71359249
25MP0000516_abnormal_urinary_system1.71359249
26MP0000566_synostosis1.69486085
27MP0005623_abnormal_meninges_morphology1.59330189
28MP0006292_abnormal_olfactory_placode1.58184692
29MP0001501_abnormal_sleep_pattern1.50023293
30MP0008789_abnormal_olfactory_epithelium1.42399122
31MP0001986_abnormal_taste_sensitivity1.39465200
32MP0009053_abnormal_anal_canal1.37648785
33MP0002837_dystrophic_cardiac_calcinosis1.35034672
34MP0000372_irregular_coat_pigmentation1.32216441
35MP0002272_abnormal_nervous_system1.30966913
36MP0002557_abnormal_social/conspecific_i1.30273204
37MP0005423_abnormal_somatic_nervous1.29944985
38MP0002067_abnormal_sensory_capabilities1.29716602
39MP0000026_abnormal_inner_ear1.27515632
40MP0001963_abnormal_hearing_physiology1.24964912
41MP0009745_abnormal_behavioral_response1.24049914
42MP0005174_abnormal_tail_pigmentation1.21390682
43MP0002733_abnormal_thermal_nociception1.19907196
44MP0005379_endocrine/exocrine_gland_phen1.19118589
45MP0000049_abnormal_middle_ear1.15767186
46MP0002282_abnormal_trachea_morphology1.15339031
47MP0005395_other_phenotype1.11455451
48MP0009046_muscle_twitch1.11223393
49MP0001984_abnormal_olfaction1.10043311
50MP0001970_abnormal_pain_threshold1.09265056
51MP0000015_abnormal_ear_pigmentation1.06379039
52MP0000955_abnormal_spinal_cord1.06127009
53MP0001440_abnormal_grooming_behavior1.03539225
54MP0001765_abnormal_ion_homeostasis1.01242565
55MP0008058_abnormal_DNA_repair1.01197059
56MP0008872_abnormal_physiological_respon0.97185198
57MP0004924_abnormal_behavior0.96247824
58MP0005386_behavior/neurological_phenoty0.96247824
59MP0002234_abnormal_pharynx_morphology0.94304865
60MP0002734_abnormal_mechanical_nocicepti0.93520738
61MP0005408_hypopigmentation0.93099174
62MP0005389_reproductive_system_phenotype0.92389906
63MP0000371_diluted_coat_color0.91868809
64MP0002938_white_spotting0.89755947
65MP0005394_taste/olfaction_phenotype0.89362160
66MP0005499_abnormal_olfactory_system0.89362160
67MP0003195_calcinosis0.87756788
68MP0003635_abnormal_synaptic_transmissio0.87640007
69MP0005647_abnormal_sex_gland0.83900533
70MP0002095_abnormal_skin_pigmentation0.80143580
71MP0004142_abnormal_muscle_tone0.79344837
72MP0002064_seizures0.75562370
73MP0000778_abnormal_nervous_system0.74990495
74MP0002882_abnormal_neuron_morphology0.72801538
75MP0002752_abnormal_somatic_nervous0.72040412
76MP0004147_increased_porphyrin_level0.71525878
77MP0002127_abnormal_cardiovascular_syste0.67796956
78MP0010329_abnormal_lipoprotein_level0.67362916
79MP0008961_abnormal_basal_metabolism0.65449675
80MP0005451_abnormal_body_composition0.64676410
81MP0004859_abnormal_synaptic_plasticity0.64405815
82MP0002063_abnormal_learning/memory/cond0.64393827
83MP0003115_abnormal_respiratory_system0.64140236
84MP0006072_abnormal_retinal_apoptosis0.62666745
85MP0005645_abnormal_hypothalamus_physiol0.62386745
86MP0000230_abnormal_systemic_arterial0.61590226
87MP0003011_delayed_dark_adaptation0.59549330
88MP0008995_early_reproductive_senescence0.57961566
89MP0005636_abnormal_mineral_homeostasis0.55432853
90MP0010094_abnormal_chromosome_stability0.53842362
91MP0004036_abnormal_muscle_relaxation0.53327104
92MP0006036_abnormal_mitochondrial_physio0.52515569
93MP0001324_abnormal_eye_pigmentation0.51397652
94MP0002269_muscular_atrophy0.50701242
95MP0003699_abnormal_female_reproductive0.50138052
96MP0001293_anophthalmia0.48927806
97MP0000358_abnormal_cell_content/0.48807503
98MP0002928_abnormal_bile_duct0.48098424
99MP0005377_hearing/vestibular/ear_phenot0.46756999
100MP0003878_abnormal_ear_physiology0.46756999
101MP0003329_amyloid_beta_deposits0.44907315
102MP0005666_abnormal_adipose_tissue0.43896741
103MP0003950_abnormal_plasma_membrane0.43472783
104MP0004133_heterotaxia0.42423077
105MP0005397_hematopoietic_system_phenotyp0.40469240
106MP0001545_abnormal_hematopoietic_system0.40469240
107MP0009278_abnormal_bone_marrow0.40331462
108MP0002102_abnormal_ear_morphology0.40114803
109MP0001764_abnormal_homeostasis0.38658443
110MP0005551_abnormal_eye_electrophysiolog0.37645564
111MP0005253_abnormal_eye_physiology0.37323743
112MP0008057_abnormal_DNA_replication0.36773681
113MP0003633_abnormal_nervous_system0.34788708
114MP0002736_abnormal_nociception_after0.34047187
115MP0009115_abnormal_fat_cell0.32518351
116MP0000534_abnormal_ureter_morphology0.32418211
117MP0004811_abnormal_neuron_physiology0.32200156
118MP0004019_abnormal_vitamin_homeostasis0.30666473
119MP0005391_vision/eye_phenotype0.29143276
120MP0001730_embryonic_growth_arrest0.29129079
121MP0003111_abnormal_nucleus_morphology0.28387904
122MP0001119_abnormal_female_reproductive0.28117172
123MP0006035_abnormal_mitochondrial_morpho0.27036669
124MP0002971_abnormal_brown_adipose0.26777900
125MP0003861_abnormal_nervous_system0.26306284
126MP0000569_abnormal_digit_pigmentation0.26190982
127MP0010307_abnormal_tumor_latency0.25086368
128MP0003631_nervous_system_phenotype0.24862968
129MP0003787_abnormal_imprinting0.24788168
130MP0002152_abnormal_brain_morphology0.24063918
131MP0003942_abnormal_urinary_system0.23285586
132MP0002139_abnormal_hepatobiliary_system0.22099235
133MP0003786_premature_aging0.21625797
134MP0002169_no_abnormal_phenotype0.21221345
135MP0002873_normal_phenotype0.20982931
136MP0002084_abnormal_developmental_patter0.20522973
137MP0000604_amyloidosis0.20457139
138MP0002132_abnormal_respiratory_system0.20272817
139MP0000313_abnormal_cell_death0.20144103
140MP0003948_abnormal_gas_homeostasis0.19292335
141MP0001968_abnormal_touch/_nociception0.17906309
142MP0008875_abnormal_xenobiotic_pharmacok0.17518226
143MP0001661_extended_life_span0.17513321
144MP0008007_abnormal_cellular_replicative0.17445407
145MP0003879_abnormal_hair_cell0.16115200
146MP0002092_abnormal_eye_morphology0.15340131
147MP0004145_abnormal_muscle_electrophysio0.15168092
148MP0005319_abnormal_enzyme/_coenzyme0.14840071
149MP0002229_neurodegeneration0.14785930
150MP0005195_abnormal_posterior_eye0.14685311
151MP0003959_abnormal_lean_body0.13842295
152MP0001697_abnormal_embryo_size0.13813345
153MP0000001_mammalian_phenotype0.13653044
154MP0002909_abnormal_adrenal_gland0.13465452
155MP0000751_myopathy0.13426723
156MP0005365_abnormal_bile_salt0.12894072
157MP0002405_respiratory_system_inflammati0.12313509
158MP0003183_abnormal_peptide_metabolism0.12194536
159MP0008569_lethality_at_weaning0.11406559
160MP0002572_abnormal_emotion/affect_behav0.11335085
161MP0004270_analgesia0.11235787
162MP0005380_embryogenesis_phenotype0.11142444
163MP0001672_abnormal_embryogenesis/_devel0.11142444

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39223109
2Abnormal respiratory motile cilium morphology (HP:0005938)8.99787999
3Abnormal respiratory epithelium morphology (HP:0012253)8.99787999
4Rhinitis (HP:0012384)7.77221149
5Abnormal ciliary motility (HP:0012262)7.42193696
6Chronic bronchitis (HP:0004469)7.41826726
7Infertility (HP:0000789)6.74975134
8Nasal polyposis (HP:0100582)6.52153800
9Severe visual impairment (HP:0001141)6.24071530
10Abnormality of the nasal mucosa (HP:0000433)5.36077103
11Bronchitis (HP:0012387)4.62165095
12Bronchiectasis (HP:0002110)4.54732585
13Male infertility (HP:0003251)4.46432471
14Nephronophthisis (HP:0000090)4.30202838
15Abnormal rod and cone electroretinograms (HP:0008323)4.24031504
16Chronic hepatic failure (HP:0100626)4.10639044
17Attenuation of retinal blood vessels (HP:0007843)3.82802033
18Abnormality of macular pigmentation (HP:0008002)3.81103734
19Pancreatic cysts (HP:0001737)3.72663860
20Abnormal spermatogenesis (HP:0008669)3.69065956
21Bony spicule pigmentary retinopathy (HP:0007737)3.68183865
22Recurrent otitis media (HP:0000403)3.31505800
23Recurrent sinusitis (HP:0011108)3.27108436
24Abnormality of the renal medulla (HP:0100957)3.20873882
25Potter facies (HP:0002009)3.20108668
26Facial shape deformation (HP:0011334)3.20108668
27Gastrointestinal atresia (HP:0002589)3.02606028
28True hermaphroditism (HP:0010459)2.96098477
29Medial flaring of the eyebrow (HP:0010747)2.88789986
30Progressive cerebellar ataxia (HP:0002073)2.86962827
31Congenital stationary night blindness (HP:0007642)2.84156349
32Molar tooth sign on MRI (HP:0002419)2.81978630
33Abnormality of midbrain morphology (HP:0002418)2.81978630
34Tubular atrophy (HP:0000092)2.76105047
35Recurrent bronchitis (HP:0002837)2.75724007
36Esophageal atresia (HP:0002032)2.75032188
37Febrile seizures (HP:0002373)2.72339755
38Type II lissencephaly (HP:0007260)2.68816337
39Large for gestational age (HP:0001520)2.68462017
40Tubulointerstitial nephritis (HP:0001970)2.67052233
41Azoospermia (HP:0000027)2.62050204
42Hyperkalemia (HP:0002153)2.61249579
43Renovascular hypertension (HP:0100817)2.51356263
44Impulsivity (HP:0100710)2.50461955
45Tubulointerstitial abnormality (HP:0001969)2.48423363
46Focal motor seizures (HP:0011153)2.47300375
47Rib fusion (HP:0000902)2.41660493
48Hypoplastic ischia (HP:0003175)2.35499886
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.33916556
50Abnormality of the nasal septum (HP:0000419)2.22541019
51Cholecystitis (HP:0001082)2.20403587
52Abnormal gallbladder physiology (HP:0012438)2.20403587
53Intestinal atresia (HP:0011100)2.17739495
54Tubulointerstitial fibrosis (HP:0005576)2.16005635
55Hypoplasia of the fovea (HP:0007750)2.12339173
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.12339173
57Gonadotropin excess (HP:0000837)2.09889824
58Retinal dysplasia (HP:0007973)2.08646737
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06232147
60Atonic seizures (HP:0010819)2.05910514
61Abnormality of the ischium (HP:0003174)2.01409777
62Dyschromatopsia (HP:0007641)2.00554731
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4488225
64Dynein arm defect of respiratory motile cilia (HP:0012255)12.8005976
65Absent/shortened dynein arms (HP:0200106)12.8005976
66Occipital encephalocele (HP:0002085)1.96108162
67Pendular nystagmus (HP:0012043)1.95614535
68Renal Fanconi syndrome (HP:0001994)1.94910263
69Polydipsia (HP:0001959)1.94604303
70Abnormal drinking behavior (HP:0030082)1.94604303
71Portal hypertension (HP:0001409)1.94230434
72Sclerocornea (HP:0000647)1.92184976
73Enlarged epiphyses (HP:0010580)1.91306903
74Delayed CNS myelination (HP:0002188)1.89138543
75Postaxial foot polydactyly (HP:0001830)1.88098762
76Decreased central vision (HP:0007663)1.86517476
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.84770761
78Thyroid-stimulating hormone excess (HP:0002925)1.84048389
79Congenital hepatic fibrosis (HP:0002612)1.82748016
80Stage 5 chronic kidney disease (HP:0003774)1.81908373
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80753882
82Photophobia (HP:0000613)1.79918036
83Generalized aminoaciduria (HP:0002909)1.79349726
84Choroideremia (HP:0001139)1.79234671
85Narrow forehead (HP:0000341)1.79024482
86Bulbous nose (HP:0000414)1.75255624
87Abnormality of potassium homeostasis (HP:0011042)1.74452294
88Optic nerve hypoplasia (HP:0000609)1.73551368
89Abnormality of renal excretion (HP:0011036)1.73386904
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72419505
91Congenital malformation of the right heart (HP:0011723)1.72387218
92Double outlet right ventricle (HP:0001719)1.72387218
93Spastic tetraparesis (HP:0001285)1.70774652
94Hyperventilation (HP:0002883)1.70319399
95Abnormality of the hepatic vasculature (HP:0006707)1.70052525
96Gaze-evoked nystagmus (HP:0000640)1.68344092
97Abnormality of the renal cortex (HP:0011035)1.67984135
98Failure to thrive in infancy (HP:0001531)1.66655764
99Intellectual disability, moderate (HP:0002342)1.66422606
100Amelogenesis imperfecta (HP:0000705)1.66307329
101Congenital primary aphakia (HP:0007707)1.65994083
102Gait imbalance (HP:0002141)1.65869148
103Aplasia/Hypoplasia of the lens (HP:0008063)1.64008213
104Abnormality of renal resorption (HP:0011038)1.63261719
105Heterotopia (HP:0002282)1.63044149
106Astigmatism (HP:0000483)1.62869951
107Delusions (HP:0000746)1.62767987
108Short ribs (HP:0000773)1.59987452
109Chronic sinusitis (HP:0011109)1.58787164
110Renal dysplasia (HP:0000110)1.57800892
111Postaxial hand polydactyly (HP:0001162)1.57758115
112Bile duct proliferation (HP:0001408)1.57751964
113Abnormal biliary tract physiology (HP:0012439)1.57751964
114Abnormality of saccadic eye movements (HP:0000570)1.57250122
115Oculomotor apraxia (HP:0000657)1.56579477
116Facial cleft (HP:0002006)1.50590067
117Abnormality of the dental root (HP:0006486)1.47141289
118Taurodontia (HP:0000679)1.47141289
119Abnormality of permanent molar morphology (HP:0011071)1.47141289
120Asymmetric septal hypertrophy (HP:0001670)1.46782547
121Hemorrhage of the eye (HP:0011885)1.46289001
122Abnormality of the lower motor neuron (HP:0002366)1.46149664
123Tongue fasciculations (HP:0001308)1.45601208
124Fibular hypoplasia (HP:0003038)1.44634621
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.43317701
126Pancreatic fibrosis (HP:0100732)1.43301121
127Abnormal urine output (HP:0012590)1.42946734
128Easy fatigability (HP:0003388)1.42282654
129Microglossia (HP:0000171)1.42208772
130Bell-shaped thorax (HP:0001591)1.40770537
131Cerebellar dysplasia (HP:0007033)1.40562365
132Nephrogenic diabetes insipidus (HP:0009806)1.40063106
133Abnormality of molar morphology (HP:0011070)1.36686795
134Abnormality of molar (HP:0011077)1.36686795
135Abnormality of the neuromuscular junction (HP:0003398)1.36576680
136Fatigable weakness (HP:0003473)1.36576680
137Neurofibrillary tangles (HP:0002185)1.36332298
138Abnormality of ocular smooth pursuit (HP:0000617)1.35830243
139Abnormality of the dental pulp (HP:0006479)1.35639349
140Cystic liver disease (HP:0006706)1.35571683
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.35354434
142Absent epiphyses (HP:0010577)1.35354434
143Bundle branch block (HP:0011710)1.33204440
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.32422670
145Absent frontal sinuses (HP:0002688)1.31680440
146Genital tract atresia (HP:0001827)1.31570973
147Muscle fibrillation (HP:0010546)1.31563639
148Deformed sella turcica (HP:0002681)1.31494894
149Abnormality of dentin (HP:0010299)1.31247402
150Vaginal atresia (HP:0000148)1.28839622
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.27556486
152Exercise-induced myalgia (HP:0003738)1.24337021
153Poor coordination (HP:0002370)1.23255193
154Median cleft lip (HP:0000161)1.23242521
155Polyuria (HP:0000103)1.23163301
156J-shaped sella turcica (HP:0002680)1.22923980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.08656826
2PDK48.08656826
3TESK16.71748354
4PDK25.22976517
5PRKD34.68441412
6ICK4.46431912
7FRK3.60861990
8BMPR1B2.92449056
9INSRR2.85585488
10MAP4K22.77260829
11PLK22.67897611
12PTK2B2.47387173
13NUAK12.40688158
14BRD42.24076630
15WNK42.21727992
16STK392.17538508
17STK382.05896163
18MAP3K91.89989270
19DDR21.82880753
20MAPK131.71422040
21NEK21.67342866
22EIF2AK31.64266120
23PNCK1.62635329
24ADRBK21.62126740
25CDK31.61549344
26ACVR1B1.49312557
27TAF11.44712219
28DYRK1B1.42584106
29EPHA41.42043506
30MKNK21.36042767
31PBK1.28664779
32PDK11.25388858
33PIK3CG1.21438667
34FGFR21.09817553
35MARK11.02414809
36PAK31.01683421
37TYRO30.93810090
38PRKCE0.92927109
39VRK20.89108316
40IRAK10.87750280
41DYRK30.86997320
42VRK10.85260188
43TNIK0.84906431
44MAPK150.83893143
45LATS10.83283058
46TSSK60.82277030
47FGFR30.81696264
48PDPK10.80569476
49ARAF0.80454554
50WNK10.75861775
51BCKDK0.74725309
52ZAK0.74642223
53MAP3K130.72956357
54LMTK20.69481240
55CCNB10.69370548
56EEF2K0.68551635
57DAPK20.68366830
58EIF2AK10.67860911
59TGFBR10.67690448
60PASK0.66968434
61CHEK20.66779712
62CASK0.66235359
63NTRK30.63911696
64PINK10.63457802
65STK30.63111921
66RIPK40.61915926
67TTK0.61871491
68TESK20.61626136
69AKT30.60534074
70NME10.58526231
71STK38L0.57432605
72CAMK10.53374855
73IRAK20.52046160
74ROCK10.51578443
75CDK70.50446295
76MAP2K60.49569168
77OXSR10.48477482
78SGK10.46297566
79PRKAA20.44974196
80WEE10.43850858
81MUSK0.42093343
82BRSK20.40437412
83TIE10.40398028
84FGFR10.39340765
85PLK40.39134925
86MST1R0.38336268
87CHEK10.37537402
88GRK10.36083853
89PAK10.36061656
90PRKCG0.35861888
91NTRK20.35588037
92CSNK1G10.33098207
93CAMK1G0.32841517
94EPHB20.30674578
95PHKG20.30086347
96PHKG10.30086347
97DYRK20.29595017
98PIK3CA0.28836515
99ATM0.27337474
100SRPK10.26496667
101ATR0.26250648
102MAP3K100.26070726
103PAK20.25754720
104ADRBK10.25547747
105MAP3K120.24592912
106MTOR0.23688213
107DYRK1A0.23572475
108MARK20.23036938
109TAOK30.22303417
110MAPKAPK50.22032006
111SIK20.22004524
112NEK60.21742863
113PRKAA10.20915346
114CAMKK10.19399427
115RPS6KB10.19305723
116BRSK10.18897240
117PRKCZ0.18037951
118PAK40.17671650
119PLK10.15382008
120PRKCQ0.14191145
121PRKG20.13499276
122CDK150.13170309
123MARK30.11208915
124CSF1R0.10542711
125CDK180.10491887
126RPS6KA10.10351379
127CDC70.09493869
128ZAP700.09436793
129CDK11A0.09400510
130MAP2K70.08998225
131CSNK2A10.08852819
132CDK120.08095459
133PKN10.07460070
134MAP3K40.07243070
135BRAF0.07031801
136STK100.06263146
137GSK3B0.05991002
138CDK140.05790091
139YES10.05467273
140STK110.04852034
141PDGFRB0.04797632
142CAMK2A0.04722045
143PIM10.04378696
144CSNK2A20.04200458
145PRKACG0.04173828
146RIPK10.03627449
147CDK20.03491257
148PRKG10.03297188
149PRKCD0.03181216
150CDK60.02836685
151MAPK80.02828274
152CDK10.02411557
153EGFR0.01524963
154AURKA0.01161586
155PRKCB0.00482889
156PRKCA0.00402880
157PRKACA-0.0351290
158RPS6KA3-0.0348699
159WNK3-0.0328989
160PRKDC-0.0250823
161MAP3K5-0.0073075
162CSNK1D-0.0057361

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.12344455
2Fatty acid biosynthesis_Homo sapiens_hsa000614.50489236
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.24253764
4Vitamin B6 metabolism_Homo sapiens_hsa007503.52505669
5Pyruvate metabolism_Homo sapiens_hsa006203.43123452
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09281500
7Linoleic acid metabolism_Homo sapiens_hsa005913.02123275
8Butanoate metabolism_Homo sapiens_hsa006502.84049970
9Propanoate metabolism_Homo sapiens_hsa006402.69804147
10Glucagon signaling pathway_Homo sapiens_hsa049222.58811592
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.51718950
12Basal transcription factors_Homo sapiens_hsa030222.50803869
13Olfactory transduction_Homo sapiens_hsa047402.46923147
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29204617
15Phototransduction_Homo sapiens_hsa047442.28724436
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19623865
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19220243
18Pentose phosphate pathway_Homo sapiens_hsa000302.11966279
19Selenocompound metabolism_Homo sapiens_hsa004502.10843935
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03218956
21Glycerolipid metabolism_Homo sapiens_hsa005611.98158206
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88389071
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81691759
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80239155
25PPAR signaling pathway_Homo sapiens_hsa033201.77045701
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.75435053
27Oocyte meiosis_Homo sapiens_hsa041141.73707405
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.73654900
29Allograft rejection_Homo sapiens_hsa053301.71674120
30Caffeine metabolism_Homo sapiens_hsa002321.64009462
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.60727636
32Amphetamine addiction_Homo sapiens_hsa050311.59231574
33Autoimmune thyroid disease_Homo sapiens_hsa053201.58641302
34Fat digestion and absorption_Homo sapiens_hsa049751.57548823
35Nitrogen metabolism_Homo sapiens_hsa009101.57129301
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52440840
37Fructose and mannose metabolism_Homo sapiens_hsa000511.50207804
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48677942
39Fanconi anemia pathway_Homo sapiens_hsa034601.45446442
40Mineral absorption_Homo sapiens_hsa049781.45185146
41Carbon metabolism_Homo sapiens_hsa012001.44567003
42Cardiac muscle contraction_Homo sapiens_hsa042601.43944459
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41933220
44Ether lipid metabolism_Homo sapiens_hsa005651.40681053
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37219924
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34878720
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32872081
48Fatty acid metabolism_Homo sapiens_hsa012121.30766821
49Tryptophan metabolism_Homo sapiens_hsa003801.26379743
50Fatty acid degradation_Homo sapiens_hsa000711.24942277
51Dorso-ventral axis formation_Homo sapiens_hsa043201.22363497
52Huntingtons disease_Homo sapiens_hsa050161.18967826
53Glutathione metabolism_Homo sapiens_hsa004801.16927099
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16894695
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.12850458
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.10567492
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.10395742
58Nicotine addiction_Homo sapiens_hsa050331.08539155
59Renin secretion_Homo sapiens_hsa049241.07125844
60Morphine addiction_Homo sapiens_hsa050321.06617896
61Asthma_Homo sapiens_hsa053101.05155903
62Type I diabetes mellitus_Homo sapiens_hsa049401.04521499
63Oxidative phosphorylation_Homo sapiens_hsa001901.03497268
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02741673
65Serotonergic synapse_Homo sapiens_hsa047261.02224075
66mRNA surveillance pathway_Homo sapiens_hsa030151.01844115
67Renin-angiotensin system_Homo sapiens_hsa046141.01181340
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99972494
69Systemic lupus erythematosus_Homo sapiens_hsa053220.99617703
70Glutamatergic synapse_Homo sapiens_hsa047240.97919960
71Homologous recombination_Homo sapiens_hsa034400.97878952
72Purine metabolism_Homo sapiens_hsa002300.97762492
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96751560
74Biosynthesis of amino acids_Homo sapiens_hsa012300.95282301
75Retinol metabolism_Homo sapiens_hsa008300.95272608
76Antigen processing and presentation_Homo sapiens_hsa046120.94117525
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91760344
78Collecting duct acid secretion_Homo sapiens_hsa049660.90676323
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89942377
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86908703
81GABAergic synapse_Homo sapiens_hsa047270.85505658
82Hedgehog signaling pathway_Homo sapiens_hsa043400.85202750
83RNA transport_Homo sapiens_hsa030130.80640029
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79294263
85Insulin secretion_Homo sapiens_hsa049110.79245096
86RNA polymerase_Homo sapiens_hsa030200.76723829
87Long-term depression_Homo sapiens_hsa047300.76695893
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.76255947
89Chemical carcinogenesis_Homo sapiens_hsa052040.75892055
90Arachidonic acid metabolism_Homo sapiens_hsa005900.75737931
91Long-term potentiation_Homo sapiens_hsa047200.74603112
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71443250
93Estrogen signaling pathway_Homo sapiens_hsa049150.70928088
94Thyroid hormone synthesis_Homo sapiens_hsa049180.69168006
95Graft-versus-host disease_Homo sapiens_hsa053320.68031118
96Bile secretion_Homo sapiens_hsa049760.67056010
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63708932
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60424157
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60242329
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.57266437
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57082288
102Parkinsons disease_Homo sapiens_hsa050120.56481065
103One carbon pool by folate_Homo sapiens_hsa006700.56315896
104Folate biosynthesis_Homo sapiens_hsa007900.55458269
105Sphingolipid metabolism_Homo sapiens_hsa006000.55250145
106Arginine and proline metabolism_Homo sapiens_hsa003300.53144243
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52612745
108Calcium signaling pathway_Homo sapiens_hsa040200.51559730
109Synaptic vesicle cycle_Homo sapiens_hsa047210.51286802
110Pancreatic secretion_Homo sapiens_hsa049720.51077625
111AMPK signaling pathway_Homo sapiens_hsa041520.50180998
112Alcoholism_Homo sapiens_hsa050340.50161829
113ABC transporters_Homo sapiens_hsa020100.48706925
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48627972
115Legionellosis_Homo sapiens_hsa051340.47905794
116Steroid biosynthesis_Homo sapiens_hsa001000.47862483
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47854666
118Regulation of autophagy_Homo sapiens_hsa041400.47703548
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47693501
120Protein export_Homo sapiens_hsa030600.47287542
121Endocytosis_Homo sapiens_hsa041440.46817977
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46537836
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.46461672
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46264466
125Inositol phosphate metabolism_Homo sapiens_hsa005620.45978208
126Protein digestion and absorption_Homo sapiens_hsa049740.42412691
127Salivary secretion_Homo sapiens_hsa049700.42110903
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.40419349
129Metabolic pathways_Homo sapiens_hsa011000.39765814
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37514862
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36247347
132Gastric acid secretion_Homo sapiens_hsa049710.34238425
133Taste transduction_Homo sapiens_hsa047420.34131066
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33183110
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32854291
136Sulfur metabolism_Homo sapiens_hsa009200.31885250
137VEGF signaling pathway_Homo sapiens_hsa043700.30514997
138Peroxisome_Homo sapiens_hsa041460.29439641
139Dopaminergic synapse_Homo sapiens_hsa047280.29161230
140cAMP signaling pathway_Homo sapiens_hsa040240.28971087
141N-Glycan biosynthesis_Homo sapiens_hsa005100.26408815
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25593725
143Cholinergic synapse_Homo sapiens_hsa047250.25533282
144Cocaine addiction_Homo sapiens_hsa050300.25510576
145Circadian entrainment_Homo sapiens_hsa047130.23997822
146Pyrimidine metabolism_Homo sapiens_hsa002400.19634209
147Viral carcinogenesis_Homo sapiens_hsa052030.18817036
148Salmonella infection_Homo sapiens_hsa051320.18716219
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17252341
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14207007
151Wnt signaling pathway_Homo sapiens_hsa043100.11574892
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09832682
153B cell receptor signaling pathway_Homo sapiens_hsa046620.09105957
154HIF-1 signaling pathway_Homo sapiens_hsa040660.08051136
155Insulin resistance_Homo sapiens_hsa049310.06098045

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