SPACA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.72127556
2epithelial cilium movement (GO:0003351)9.66321374
3axonemal dynein complex assembly (GO:0070286)9.48645495
4motile cilium assembly (GO:0044458)9.46973596
5reproduction (GO:0000003)9.26849705
6cilium or flagellum-dependent cell motility (GO:0001539)8.88430599
7response to pheromone (GO:0019236)8.19935354
8regulation of cilium movement (GO:0003352)7.96217977
9cilium movement (GO:0003341)7.80200290
10sperm capacitation (GO:0048240)7.41121023
11single fertilization (GO:0007338)7.18499999
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.05142969
13synaptonemal complex organization (GO:0070193)6.94603499
14synaptonemal complex assembly (GO:0007130)6.86974892
15rRNA methylation (GO:0031167)6.86881454
16organic cation transport (GO:0015695)6.79733735
17negative regulation of inclusion body assembly (GO:0090084)6.76916990
18male meiosis (GO:0007140)6.70083041
19spermatogenesis (GO:0007283)6.66446429
20male gamete generation (GO:0048232)6.63938225
21piRNA metabolic process (GO:0034587)6.54083224
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.50223268
23protein targeting to Golgi (GO:0000042)6.23809456
24fertilization (GO:0009566)6.16286407
25microtubule depolymerization (GO:0007019)6.15594443
26gamete generation (GO:0007276)6.09886187
27establishment of protein localization to Golgi (GO:0072600)5.99005740
28phosphatidylethanolamine metabolic process (GO:0046337)5.96298569
29retrograde transport, vesicle recycling within Golgi (GO:0000301)5.84159300
30regulation of inclusion body assembly (GO:0090083)5.75817209
31rRNA modification (GO:0000154)5.74651226
32calcium ion-dependent exocytosis (GO:0017156)5.61630214
33cellular ketone body metabolic process (GO:0046950)5.58217560
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.49067745
35germ cell development (GO:0007281)5.41109454
36spermatid nucleus differentiation (GO:0007289)5.40717419
37chromosome condensation (GO:0030261)5.38413609
38DNA packaging (GO:0006323)5.17829933
39cell recognition (GO:0008037)5.09670623
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05545790
41ventricular system development (GO:0021591)4.97425591
42ketone body metabolic process (GO:1902224)4.90412019
43positive regulation of Rab GTPase activity (GO:0032851)4.81147894
44regulation of Rab GTPase activity (GO:0032313)4.81147894
45multicellular organismal reproductive process (GO:0048609)4.79936370
46seminiferous tubule development (GO:0072520)4.77400541
47microtubule severing (GO:0051013)4.74124507
48centriole replication (GO:0007099)4.73632204
49regulation of microtubule-based movement (GO:0060632)4.66118301
50glycerol ether metabolic process (GO:0006662)4.64289146
51chromosome organization involved in meiosis (GO:0070192)4.58478765
52male meiosis I (GO:0007141)4.57902323
53protein localization to Golgi apparatus (GO:0034067)4.56065795
54sexual reproduction (GO:0019953)4.45242411
55ether metabolic process (GO:0018904)4.28560470
56DNA methylation involved in gamete generation (GO:0043046)4.25150818
57sequestering of actin monomers (GO:0042989)4.24651403
58left/right pattern formation (GO:0060972)4.17295481
59single strand break repair (GO:0000012)4.08301470
60meiotic nuclear division (GO:0007126)4.07585907
61chaperone-mediated protein complex assembly (GO:0051131)3.98901562
62regulation of transcription involved in cell fate commitment (GO:0060850)3.95792794
63multicellular organismal development (GO:0007275)3.85865558
64negative regulation of Rho protein signal transduction (GO:0035024)3.82707294
65coenzyme catabolic process (GO:0009109)3.79236107
66glomerular visceral epithelial cell development (GO:0072015)3.75686954
67glomerular epithelial cell development (GO:0072310)3.75157724
68regulation of centriole replication (GO:0046599)3.74057008
69regulation of interleukin-13 production (GO:0032656)3.67756698
70response to acidic pH (GO:0010447)3.65670360
71meiosis I (GO:0007127)3.64265655
72histone H3-K9 demethylation (GO:0033169)3.62440084
73genitalia morphogenesis (GO:0035112)3.59393711
74regulation of ARF GTPase activity (GO:0032312)3.52396345
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.49949384
76positive regulation of macrophage activation (GO:0043032)3.46663730
77protein K11-linked deubiquitination (GO:0035871)3.43451978
78protein polyglutamylation (GO:0018095)3.39698199
79cellular response to pH (GO:0071467)3.38967872
80membrane protein intracellular domain proteolysis (GO:0031293)3.38492827
81monoubiquitinated protein deubiquitination (GO:0035520)3.37368043
82interferon-gamma secretion (GO:0072643)3.33298772
83protein depolymerization (GO:0051261)3.32724104
84amino-acid betaine transport (GO:0015838)3.30601468
85carnitine transport (GO:0015879)3.30601468
86musculoskeletal movement (GO:0050881)3.29407609
87multicellular organismal movement (GO:0050879)3.29407609
88regulation of spindle checkpoint (GO:0090231)3.25815800
89negative regulation of gene expression, epigenetic (GO:0045814)3.25754194
90meiotic cell cycle (GO:0051321)3.22146247
91nucleus organization (GO:0006997)3.18020769
92protein localization to cilium (GO:0061512)3.15487150
93regulation of T-helper 2 cell differentiation (GO:0045628)3.15285587
94carnitine transmembrane transport (GO:1902603)3.12704244
95protein refolding (GO:0042026)3.11957202
96microtubule polymerization or depolymerization (GO:0031109)3.10657584
97RNA localization (GO:0006403)3.08226992
98DNA conformation change (GO:0071103)3.01405533
99glycolytic process (GO:0006096)2.98267661
100cerebral cortex neuron differentiation (GO:0021895)2.97172040
101RNA destabilization (GO:0050779)2.96239222
102microtubule nucleation (GO:0007020)2.95236386
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92241166
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92241166
105receptor recycling (GO:0001881)2.89780019
106peptidyl-threonine dephosphorylation (GO:0035970)2.88656811
107cranial nerve morphogenesis (GO:0021602)2.86391364
108polyamine biosynthetic process (GO:0006596)2.85892370
109mitotic sister chromatid cohesion (GO:0007064)2.84011326
110polyol catabolic process (GO:0046174)2.81488003
111alditol metabolic process (GO:0019400)2.81146753
112homeostasis of number of cells within a tissue (GO:0048873)2.80616045
113mitotic G1 DNA damage checkpoint (GO:0031571)2.78324946
114regulation of interleukin-5 production (GO:0032674)2.78239612
115actin filament capping (GO:0051693)2.76583453
116cell differentiation involved in metanephros development (GO:0072202)2.74355974
117nucleoside diphosphate phosphorylation (GO:0006165)2.74293442
118axoneme assembly (GO:0035082)2.73720559
119regulation of somitogenesis (GO:0014807)2.71427912
120cilium organization (GO:0044782)2.69558748
121regulation of cilium assembly (GO:1902017)2.66790108
122microtubule-based movement (GO:0007018)2.65136845
123chromatin silencing (GO:0006342)2.65103962
124meiotic cell cycle process (GO:1903046)2.64853773
125nucleosome disassembly (GO:0006337)2.63602476
126protein-DNA complex disassembly (GO:0032986)2.63602476
127negative regulation of organelle assembly (GO:1902116)2.62529211
128cellular component assembly involved in morphogenesis (GO:0010927)2.59357386
129cilium morphogenesis (GO:0060271)2.59021485
130cilium assembly (GO:0042384)2.57244517
131centriole assembly (GO:0098534)2.55268131
132intraciliary transport (GO:0042073)2.53112475
133synapsis (GO:0007129)2.51588735
134lactate metabolic process (GO:0006089)2.47238256
135peptidyl-glutamic acid modification (GO:0018200)2.46279822
136glycerol metabolic process (GO:0006071)2.40158716
137cell wall macromolecule metabolic process (GO:0044036)14.8321367
138cell wall macromolecule catabolic process (GO:0016998)14.8321367
139fusion of sperm to egg plasma membrane (GO:0007342)13.6242193
140sperm motility (GO:0030317)13.4647365
141acrosome reaction (GO:0007340)12.2055744
142sperm-egg recognition (GO:0035036)11.7590638
143acrosome assembly (GO:0001675)11.7354623
144binding of sperm to zona pellucida (GO:0007339)10.6758608
145multicellular organism reproduction (GO:0032504)10.6445178
146cell-cell recognition (GO:0009988)10.5650813
147plasma membrane fusion (GO:0045026)10.3573998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.81241478
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.31757002
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.92225985
4EZH2_22144423_ChIP-Seq_EOC_Human3.65090864
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61186703
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41000964
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.32290062
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17231183
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97026767
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83347010
11DROSHA_22980978_ChIP-Seq_HELA_Human2.38401696
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.32545376
13LXR_22292898_ChIP-Seq_THP-1_Human2.32382182
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31865946
15VDR_22108803_ChIP-Seq_LS180_Human2.31602832
16CTCF_27219007_Chip-Seq_Bcells_Human2.31550762
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.25420694
18P68_20966046_ChIP-Seq_HELA_Human2.14957803
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.13080129
20ERA_21632823_ChIP-Seq_H3396_Human2.06514579
21ZNF274_21170338_ChIP-Seq_K562_Hela2.06382446
22BCL6_27268052_Chip-Seq_Bcells_Human2.04371680
23SMC4_20622854_ChIP-Seq_HELA_Human2.04203271
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.97928688
25RAC3_21632823_ChIP-Seq_H3396_Human1.94504115
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90306331
27* E2F1_20622854_ChIP-Seq_HELA_Human1.90144799
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89005154
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.88963739
30TP63_22573176_ChIP-Seq_HFKS_Human1.84754008
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83462482
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77250543
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75761129
34* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72765230
35STAT1_17558387_ChIP-Seq_HELA_Human1.72199382
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.71606965
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.71394291
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70362783
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65212983
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.63977742
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61851258
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61575962
43TAF2_19829295_ChIP-Seq_ESCs_Human1.58733481
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58458763
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.58194740
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57805198
47MYC_19829295_ChIP-Seq_ESCs_Human1.56397464
48OCT4_20526341_ChIP-Seq_ESCs_Human1.56159098
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.52904363
50P300_27268052_Chip-Seq_Bcells_Human1.49859510
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46775510
52KDM2B_26808549_Chip-Seq_REH_Human1.43668652
53SA1_27219007_Chip-Seq_Bcells_Human1.43516763
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43118062
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.42726021
56CBP_20019798_ChIP-Seq_JUKART_Human1.42325647
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42325647
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42036663
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41478529
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.41424518
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40594578
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.40580384
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39365760
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39301690
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37774274
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36914792
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36710146
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.35282353
69* P53_21459846_ChIP-Seq_SAOS-2_Human1.32109002
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28996011
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27718272
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27296880
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27105447
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.23890269
75RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23360405
76KLF5_25053715_ChIP-Seq_YYC3_Human1.22805170
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.22250163
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22200912
79REST_21632747_ChIP-Seq_MESCs_Mouse1.21819191
80CEBPB_22108803_ChIP-Seq_LS180_Human1.21128384
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.21076695
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19867938
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.19769892
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19151032
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18983875
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18632570
87GF1_26923725_Chip-Seq_HPCs_Mouse1.18507598
88FUS_26573619_Chip-Seq_HEK293_Human1.17417649
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.16556147
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.16532454
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16415786
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16109149
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.15885974
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14692830
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14613139
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14460811
97OCT4_19829295_ChIP-Seq_ESCs_Human1.14319325
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14298748
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13944900
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13540803
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12741839
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12524258
103KLF4_19829295_ChIP-Seq_ESCs_Human1.12414517
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.12276401
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.12052341
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.11950360
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.10725323
108EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10612509
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10475650
110ER_23166858_ChIP-Seq_MCF-7_Human1.10334129
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09932189
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09340465
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09169660
114RBPJ_21746931_ChIP-Seq_IB4_Human1.08899900
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08553989
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08510847
117ERG_20517297_ChIP-Seq_VCAP_Human1.08205747
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08078944
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.07842806
120GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07197031
121ESET_19884257_ChIP-Seq_ESCs_Mouse1.05838567
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05626898
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05134306
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.04916290
125LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03966615
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.03719958
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03426127
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02791719
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.02388487
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.01907625
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01753955
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01753955
133RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01678080
134CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01348291
135* CTCF_21964334_Chip-Seq_Bcells_Human1.01189722
136ETV1_20927104_ChIP-Seq_GIST48_Human1.01185449
137NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01111140
138TP53_18474530_ChIP-ChIP_U2OS_Human1.00786744
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.00719957
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00466789
141E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00105543
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00089676
143CTCF_20526341_ChIP-Seq_ESCs_Human0.97852258
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.97781804
145* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97531174
146FLI1_21867929_ChIP-Seq_CD8_Mouse0.96717452
147RUNX_20019798_ChIP-Seq_JUKART_Human0.96643964
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.96250054
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95721638
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95372706
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95240486
152GATA1_19941826_ChIP-Seq_K562_Human0.94275527
153AR_25329375_ChIP-Seq_VCAP_Human0.94027215
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93838077
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.91910374
156BCOR_27268052_Chip-Seq_Bcells_Human0.90303614
157P53_22387025_ChIP-Seq_ESCs_Mouse0.90019734
158SOX2_21211035_ChIP-Seq_LN229_Human0.89489068
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89352018
160SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89290772
161PHF8_20622854_ChIP-Seq_HELA_Human0.89135030
162NANOG_20526341_ChIP-Seq_ESCs_Human0.87223465
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86686336
164NFYB_21822215_ChIP-Seq_K562_Human0.85732500
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.85618861
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85602266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04489972
2MP0001929_abnormal_gametogenesis5.52790937
3MP0008877_abnormal_DNA_methylation3.65592443
4MP0000678_abnormal_parathyroid_gland3.56527082
5MP0001348_abnormal_lacrimal_gland3.53282502
6MP0002210_abnormal_sex_determination3.29366007
7MP0002161_abnormal_fertility/fecundity3.25783086
8MP0001145_abnormal_male_reproductive2.86951740
9MP0005670_abnormal_white_adipose2.74383127
10MP0000653_abnormal_sex_gland2.48255839
11MP0002249_abnormal_larynx_morphology2.36833569
12MP0002653_abnormal_ependyma_morphology2.16392240
13MP0005410_abnormal_fertilization16.7069918
14MP0002160_abnormal_reproductive_system1.98561303
15MP0003718_maternal_effect1.96902512
16MP0004233_abnormal_muscle_weight1.75388847
17MP0003646_muscle_fatigue1.62203735
18MP0003136_yellow_coat_color1.60617824
19MP0004510_myositis1.52324534
20MP0005423_abnormal_somatic_nervous1.45246631
21MP0005310_abnormal_salivary_gland1.37005167
22MP0001485_abnormal_pinna_reflex1.35826320
23MP0009053_abnormal_anal_canal1.31131054
24MP0005409_darkened_coat_color1.26238654
25MP0001968_abnormal_touch/_nociception1.25379747
26MP0001765_abnormal_ion_homeostasis1.20295878
27MP0005623_abnormal_meninges_morphology1.17277214
28MP0001486_abnormal_startle_reflex1.16844556
29MP0000681_abnormal_thyroid_gland1.13105666
30MP0005379_endocrine/exocrine_gland_phen1.12550932
31MP0006292_abnormal_olfactory_placode1.07955613
32MP0002234_abnormal_pharynx_morphology1.06519851
33MP0002735_abnormal_chemical_nociception1.06501676
34MP0002138_abnormal_hepatobiliary_system1.04145192
35MP0005083_abnormal_biliary_tract1.04024717
36MP0002127_abnormal_cardiovascular_syste1.03779134
37MP0001188_hyperpigmentation1.02911601
38MP0000026_abnormal_inner_ear1.02510902
39MP0004859_abnormal_synaptic_plasticity1.02117625
40MP0002282_abnormal_trachea_morphology1.00901180
41MP0005248_abnormal_Harderian_gland0.97126134
42MP0001963_abnormal_hearing_physiology0.96458419
43MP0005451_abnormal_body_composition0.96199486
44MP0005389_reproductive_system_phenotype0.94763474
45MP0000003_abnormal_adipose_tissue0.92362699
46MP0005375_adipose_tissue_phenotype0.92043545
47MP0000049_abnormal_middle_ear0.89732380
48MP0005395_other_phenotype0.89656828
49MP0000467_abnormal_esophagus_morphology0.87419909
50MP0001984_abnormal_olfaction0.86540217
51MP0001879_abnormal_lymphatic_vessel0.82501767
52MP0005377_hearing/vestibular/ear_phenot0.80620966
53MP0003878_abnormal_ear_physiology0.80620966
54MP0005647_abnormal_sex_gland0.78926870
55MP0003115_abnormal_respiratory_system0.76608076
56MP0000566_synostosis0.76264079
57MP0003172_abnormal_lysosome_physiology0.71604298
58MP0005636_abnormal_mineral_homeostasis0.71409088
59MP0002229_neurodegeneration0.71346393
60MP0001666_abnormal_nutrient_absorption0.69282157
61MP0008058_abnormal_DNA_repair0.66684713
62MP0005367_renal/urinary_system_phenotyp0.65396639
63MP0000516_abnormal_urinary_system0.65396639
64MP0003119_abnormal_digestive_system0.64136266
65MP0009046_muscle_twitch0.57869641
66MP0004085_abnormal_heartbeat0.57425128
67MP0008995_early_reproductive_senescence0.57045496
68MP0004782_abnormal_surfactant_physiolog0.55922990
69MP0010368_abnormal_lymphatic_system0.55040411
70MP0005666_abnormal_adipose_tissue0.54356966
71MP0002733_abnormal_thermal_nociception0.53846935
72MP0000470_abnormal_stomach_morphology0.53421822
73MP0002254_reproductive_system_inflammat0.52787908
74MP0000955_abnormal_spinal_cord0.52387091
75MP0004381_abnormal_hair_follicle0.51023316
76MP0008569_lethality_at_weaning0.50870727
77MP0002269_muscular_atrophy0.50263670
78MP0003329_amyloid_beta_deposits0.50140795
79MP0003011_delayed_dark_adaptation0.49653077
80MP0005167_abnormal_blood-brain_barrier0.49381597
81MP0006036_abnormal_mitochondrial_physio0.49316239
82MP0000358_abnormal_cell_content/0.48422010
83MP0001324_abnormal_eye_pigmentation0.48066516
84MP0002932_abnormal_joint_morphology0.47234020
85MP0005595_abnormal_vascular_smooth0.46454828
86MP0002067_abnormal_sensory_capabilities0.45935351
87MP0003950_abnormal_plasma_membrane0.45753231
88MP0003699_abnormal_female_reproductive0.44057861
89MP0000015_abnormal_ear_pigmentation0.44005213
90MP0003137_abnormal_impulse_conducting0.43251776
91MP0001970_abnormal_pain_threshold0.43163114
92MP0002557_abnormal_social/conspecific_i0.42771231
93MP0005535_abnormal_body_temperature0.41971455
94MP0003091_abnormal_cell_migration0.41608274
95MP0000013_abnormal_adipose_tissue0.41320923
96MP0004036_abnormal_muscle_relaxation0.40999027
97MP0002928_abnormal_bile_duct0.40852980
98MP0000249_abnormal_blood_vessel0.40799850
99MP0000462_abnormal_digestive_system0.40683513
100MP0000230_abnormal_systemic_arterial0.40185975
101MP0004264_abnormal_extraembryonic_tissu0.40020144
102MP0001545_abnormal_hematopoietic_system0.39783864
103MP0005397_hematopoietic_system_phenotyp0.39783864
104MP0001293_anophthalmia0.39709489
105MP0002102_abnormal_ear_morphology0.39341195
106MP0000534_abnormal_ureter_morphology0.38407147
107MP0001764_abnormal_homeostasis0.37641847
108MP0010094_abnormal_chromosome_stability0.37455300
109MP0009278_abnormal_bone_marrow0.37212460
110MP0002572_abnormal_emotion/affect_behav0.37100479
111MP0002139_abnormal_hepatobiliary_system0.36902950
112MP0001849_ear_inflammation0.36495248
113MP0009115_abnormal_fat_cell0.35722086
114MP0002136_abnormal_kidney_physiology0.35343155
115MP0000613_abnormal_salivary_gland0.33113593
116MP0004019_abnormal_vitamin_homeostasis0.33073713
117MP0001730_embryonic_growth_arrest0.32619152
118MP0000569_abnormal_digit_pigmentation0.31417218
119MP0003111_abnormal_nucleus_morphology0.30111196
120MP0005551_abnormal_eye_electrophysiolog0.29826023
121MP0001873_stomach_inflammation0.29691925
122MP0000537_abnormal_urethra_morphology0.28679906
123MP0002736_abnormal_nociception_after0.28625468
124MP0010307_abnormal_tumor_latency0.28600646
125MP0005253_abnormal_eye_physiology0.27402266
126MP0004043_abnormal_pH_regulation0.27150609
127MP0005360_urolithiasis0.26759319
128MP0008875_abnormal_xenobiotic_pharmacok0.26636403
129MP0006035_abnormal_mitochondrial_morpho0.26156921
130MP0002971_abnormal_brown_adipose0.25595911
131MP0000604_amyloidosis0.25104698
132MP0003879_abnormal_hair_cell0.24891032
133MP0005365_abnormal_bile_salt0.24520252
134MP0001661_extended_life_span0.24413672
135MP0002796_impaired_skin_barrier0.24406359
136MP0004811_abnormal_neuron_physiology0.24107307
137MP0003866_abnormal_defecation0.23473096
138MP0005391_vision/eye_phenotype0.22992653
139MP0003861_abnormal_nervous_system0.22664963
140MP0003942_abnormal_urinary_system0.22012741
141MP0002132_abnormal_respiratory_system0.21767784
142MP0002169_no_abnormal_phenotype0.21350199
143MP0002873_normal_phenotype0.21018931
144MP0003633_abnormal_nervous_system0.20985795
145MP0003045_fibrosis0.20375508
146MP0003183_abnormal_peptide_metabolism0.20116158
147MP0003948_abnormal_gas_homeostasis0.19466371
148MP0002822_catalepsy0.19349542
149MP0002084_abnormal_developmental_patter0.19334966
150MP0004133_heterotaxia0.18911932
151MP0002152_abnormal_brain_morphology0.18132245
152MP0001119_abnormal_female_reproductive0.18009643
153MP0003252_abnormal_bile_duct0.17961056
154MP0000313_abnormal_cell_death0.17871779
155MP0003787_abnormal_imprinting0.17855689
156MP0001664_abnormal_digestion0.17834586
157MP0003936_abnormal_reproductive_system0.17628294
158MP0004742_abnormal_vestibular_system0.17624263
159MP0002909_abnormal_adrenal_gland0.17385100
160MP0005319_abnormal_enzyme/_coenzyme0.17346928
161MP0008961_abnormal_basal_metabolism0.16560822
162MP0002092_abnormal_eye_morphology0.15070414
163MP0004270_analgesia0.14828247
164MP0003631_nervous_system_phenotype0.14673409

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.18354663
2Abnormal respiratory motile cilium morphology (HP:0005938)9.13828297
3Abnormal respiratory epithelium morphology (HP:0012253)9.13828297
4Severe visual impairment (HP:0001141)8.17393410
5Rhinitis (HP:0012384)7.69955978
6Chronic bronchitis (HP:0004469)7.46658733
7Abnormal ciliary motility (HP:0012262)7.07751980
8Infertility (HP:0000789)6.93849163
9Nasal polyposis (HP:0100582)6.55862115
10Abnormality of the nasal mucosa (HP:0000433)5.38255330
11Hyperkalemia (HP:0002153)4.85064846
12Attenuation of retinal blood vessels (HP:0007843)4.79989074
13Bony spicule pigmentary retinopathy (HP:0007737)4.78823746
14Bronchitis (HP:0012387)4.57270235
15Bronchiectasis (HP:0002110)4.55140681
16Male infertility (HP:0003251)4.39675806
17Chronic hepatic failure (HP:0100626)4.28869103
18Nephronophthisis (HP:0000090)4.25778101
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02112518
20Resting tremor (HP:0002322)3.98552408
21Abnormal rod and cone electroretinograms (HP:0008323)3.96742301
22Hypoplastic ischia (HP:0003175)3.89397012
23Enlarged epiphyses (HP:0010580)3.77925101
24Abnormality of macular pigmentation (HP:0008002)3.66247279
25Abnormal spermatogenesis (HP:0008669)3.55704581
26Facial shape deformation (HP:0011334)3.46561957
27Potter facies (HP:0002009)3.46561957
28Cone-rod dystrophy (HP:0000548)3.44739511
29Abnormality of the ischium (HP:0003174)3.40939157
30Recurrent otitis media (HP:0000403)3.29286209
31Progressive sensorineural hearing impairment (HP:0000408)3.25851026
32Abnormality of the renal medulla (HP:0100957)3.18912807
33Recurrent sinusitis (HP:0011108)3.15688291
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.09784228
35Aplasia/Hypoplasia of the earlobes (HP:0009906)3.06906265
36Hypoalphalipoproteinemia (HP:0003233)2.88101150
37Tubulointerstitial nephritis (HP:0001970)2.82149972
38Impulsivity (HP:0100710)2.78694047
39Tubular atrophy (HP:0000092)2.76179447
40Hypoplasia of the thymus (HP:0000778)2.74328509
41Abnormality of the aortic arch (HP:0012303)2.73523975
42Postural instability (HP:0002172)2.71506286
43Unilateral renal agenesis (HP:0000122)2.69997681
44Recurrent bronchitis (HP:0002837)2.64344570
45Abnormality of potassium homeostasis (HP:0011042)2.63532059
46Amelogenesis imperfecta (HP:0000705)2.62941899
47Flattened epiphyses (HP:0003071)2.62806498
48Medial flaring of the eyebrow (HP:0010747)2.58782776
49Cholecystitis (HP:0001082)2.58266410
50Abnormal gallbladder physiology (HP:0012438)2.58266410
51Abnormality of the costochondral junction (HP:0000919)2.58195562
52Abnormality of midbrain morphology (HP:0002418)2.54985106
53Molar tooth sign on MRI (HP:0002419)2.54985106
54Azoospermia (HP:0000027)2.52281440
55Tubulointerstitial abnormality (HP:0001969)2.49271083
56Portal hypertension (HP:0001409)2.43173449
57Neoplasm of the heart (HP:0100544)2.39884018
58Atelectasis (HP:0100750)2.38497845
59Abnormality of the hepatic vasculature (HP:0006707)2.36138274
60Abnormality of chloride homeostasis (HP:0011422)2.34100996
61Renovascular hypertension (HP:0100817)2.33505336
62Truncal obesity (HP:0001956)2.31183143
63Abnormality of dental color (HP:0011073)2.28939418
64Hyponatremia (HP:0002902)2.28830291
65Widely patent fontanelles and sutures (HP:0004492)2.27522509
66Gonadotropin excess (HP:0000837)2.23595737
67Focal segmental glomerulosclerosis (HP:0000097)2.20491428
68Insulin-resistant diabetes mellitus (HP:0000831)2.19675399
69Generalized aminoaciduria (HP:0002909)2.18332964
70Abnormality of the epiphysis of the femoral head (HP:0010574)2.15457363
71Dyschromatopsia (HP:0007641)2.14127913
72Abnormality of femoral epiphyses (HP:0006499)2.09388803
73Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.09388803
74Tubulointerstitial fibrosis (HP:0005576)2.09089030
75Abnormality of the femoral head (HP:0003368)2.09039439
76Ventricular tachycardia (HP:0004756)2.05979742
77Progressive hearing impairment (HP:0001730)2.05903014
78Menstrual irregularities (HP:0000858)2.01930918
79Abnormality of the parathyroid morphology (HP:0011766)2.01515062
80Choroideremia (HP:0001139)2.00974683
81Absent/shortened dynein arms (HP:0200106)13.0503913
82Dynein arm defect of respiratory motile cilia (HP:0012255)13.0503913
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0125564
84Flat capital femoral epiphysis (HP:0003370)1.97697704
85Progressive cerebellar ataxia (HP:0002073)1.94894278
86Hypophosphatemic rickets (HP:0004912)1.93997255
87Spastic tetraparesis (HP:0001285)1.90762611
88Hypoparathyroidism (HP:0000829)1.86999918
89Stage 5 chronic kidney disease (HP:0003774)1.85106298
90Heterotopia (HP:0002282)1.84318831
91Epiphyseal dysplasia (HP:0002656)1.83244040
92Decreased central vision (HP:0007663)1.82937626
93Hyperuricemia (HP:0002149)1.81835171
94Increased purine levels (HP:0004368)1.81835171
95Congenital malformation of the right heart (HP:0011723)1.81143513
96Double outlet right ventricle (HP:0001719)1.81143513
97Osteomalacia (HP:0002749)1.80773330
98Polyuria (HP:0000103)1.79432303
99Tetany (HP:0001281)1.78067186
100Bradycardia (HP:0001662)1.77431385
101Abnormal drinking behavior (HP:0030082)1.77037582
102Polydipsia (HP:0001959)1.77037582
103Abnormality of the pubic bones (HP:0003172)1.76896087
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76678370
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75112643
106Vertebral clefting (HP:0008428)1.74596717
107Occipital encephalocele (HP:0002085)1.74404536
108Glomerulosclerosis (HP:0000096)1.73792397
109Abnormality of renal excretion (HP:0011036)1.71542296
110Hemorrhage of the eye (HP:0011885)1.68515405
111Postaxial foot polydactyly (HP:0001830)1.67358920
112Abnormality of the renal cortex (HP:0011035)1.63715588
113Fatigable weakness (HP:0003473)1.61211913
114Abnormality of the neuromuscular junction (HP:0003398)1.61211913
115Congenital hepatic fibrosis (HP:0002612)1.59898711
116Easy fatigability (HP:0003388)1.57794184
117Short ribs (HP:0000773)1.56373470
118Bundle branch block (HP:0011710)1.55339068
119Aplasia/Hypoplasia of the lens (HP:0008063)1.53175407
120Abnormality of permanent molar morphology (HP:0011071)1.51160094
121Abnormality of the dental root (HP:0006486)1.51160094
122Taurodontia (HP:0000679)1.51160094
123Chronic sinusitis (HP:0011109)1.47656886
124Neurofibrillary tangles (HP:0002185)1.47579756
125Bell-shaped thorax (HP:0001591)1.47260629
126Cerebellar dysplasia (HP:0007033)1.46053831
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.46015927
128Renal dysplasia (HP:0000110)1.45707657
129Oculomotor apraxia (HP:0000657)1.45156005
130Abnormal biliary tract physiology (HP:0012439)1.43560560
131Bile duct proliferation (HP:0001408)1.43560560
132Congenital primary aphakia (HP:0007707)1.41687279
133Postaxial hand polydactyly (HP:0001162)1.41495663
134Gait imbalance (HP:0002141)1.40982686
135Asymmetric septal hypertrophy (HP:0001670)1.39036726
136Abnormality of the dental pulp (HP:0006479)1.38903148
137Abnormality of molar morphology (HP:0011070)1.38424385
138Abnormality of molar (HP:0011077)1.38424385
139Sensory axonal neuropathy (HP:0003390)1.37831819
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37237426
141Absent epiphyses (HP:0010577)1.37237426
142Abnormality of the lower motor neuron (HP:0002366)1.35812608
143Abnormal urine output (HP:0012590)1.35645465
144Abnormality of dentin (HP:0010299)1.30780547
145Fibular hypoplasia (HP:0003038)1.30258162
146Loss of speech (HP:0002371)1.28989039
147Abnormality of saccadic eye movements (HP:0000570)1.28952003
148Short femoral neck (HP:0100864)1.28584767
149Facial cleft (HP:0002006)1.26500408
150Cerebral inclusion bodies (HP:0100314)1.26445243
151Cystic liver disease (HP:0006706)1.21455520
152Generalized muscle weakness (HP:0003324)1.20963481
153Myoglobinuria (HP:0002913)1.20004995
154Deformed sella turcica (HP:0002681)1.19847846
155Vascular calcification (HP:0004934)1.19704397
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18955252
157Short thorax (HP:0010306)1.18339471
158Amyotrophic lateral sclerosis (HP:0007354)1.18043143
159Abnormality of ocular smooth pursuit (HP:0000617)1.18043004
160Nephrogenic diabetes insipidus (HP:0009806)1.17816928
161Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.16286283
162Hypercholesterolemia (HP:0003124)1.15632946
163Exercise-induced myalgia (HP:0003738)1.15236921
164Rhabdomyolysis (HP:0003201)1.14803662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.80624783
2PDK37.80624783
3TESK17.33714927
4PDK25.03082975
5PRKD34.83361118
6DDR24.72239125
7ICK4.70478115
8INSRR3.65374000
9MAP4K23.45684310
10BRD43.06423665
11PLK22.35288872
12PTK2B2.29259905
13WNK42.12263957
14STK382.01865727
15STK392.00761765
16NEK21.75921158
17PNCK1.59746866
18DYRK1B1.53730738
19PIK3CG1.39641520
20CDK71.25884143
21PDK11.24104673
22RPS6KA21.05269546
23MAP3K90.98802692
24EEF2K0.94089455
25SIK20.91144012
26KSR20.90714354
27LMTK20.90178049
28IRAK10.88040354
29TYRO30.83767924
30MAP3K110.83205056
31PDPK10.82619203
32DYRK30.78931071
33KDR0.77241161
34PRKAA20.76126187
35CAMK1D0.75663058
36WNK10.74670277
37EPHA20.73335261
38TESK20.73164420
39MAPK150.72692895
40SIK10.72662484
41PASK0.71286133
42RIPK40.70115641
43MET0.69224211
44STK30.67787815
45LATS20.65312226
46AKT30.64082550
47NTRK30.62894590
48RPS6KL10.62783445
49RPS6KC10.62783445
50TTK0.62440057
51ROCK10.61426218
52CHEK20.59964853
53CCNB10.58090204
54MAP2K60.56481776
55RPS6KA60.55830295
56MAP3K20.55387412
57CAMK10.54406252
58MAP3K70.53789446
59IRAK20.49546663
60UHMK10.48753809
61MAP3K100.47342556
62MAP3K80.46824557
63NME10.46496840
64CDK30.46138109
65TIE10.45674245
66MAPK10.44627521
67TNK20.44136333
68CAMK1G0.43972441
69PINK10.42437860
70PAK10.41762802
71PAK20.38538099
72MUSK0.37462612
73CHEK10.34396431
74PAK40.34207097
75PLK40.32606787
76STK38L0.31626362
77MST1R0.31481723
78PRKG20.30995431
79SGK2230.30499265
80SGK4940.30499265
81MTOR0.30174590
82NTRK20.29022540
83MARK20.28481595
84CHUK0.27568386
85LATS10.27346253
86ARAF0.26849146
87PRKCG0.26763011
88ATM0.25614382
89PRKAA10.25139945
90MAPK100.23707525
91SGK10.23310753
92CDK120.22496988
93MAPK140.22451609
94CAMKK10.22347308
95RIPK10.22146863
96ERBB20.21482061
97ATR0.19449179
98FER0.19120516
99CAMK40.18365880
100RPS6KB10.17793012
101BLK0.17519874
102MAPKAPK50.16615051
103MAP3K130.16485155
104STK100.15555634
105AKT10.15545013
106PRKCZ0.15459961
107PRKCQ0.14329425
108MAPK110.13861196
109BRSK20.13295393
110TLK10.12817651
111NEK60.12767816
112RPS6KA10.12629090
113GRK60.12347317
114FRK0.11976632
115WEE10.11164975
116MARK10.10285093
117CDK150.09046464
118PLK10.08850407
119EPHB10.07695275
120IKBKB0.07369017
121CSF1R0.06792681
122CDC70.06224565
123CDK180.06148909
124CDK11A0.05901151
125GSK3B0.05353433
126BRSK10.05118725
127BRAF0.04999086
128CDK60.04793282
129PKN10.04425844
130PTK60.04355959
131PRKACG0.04285247
132CSNK2A10.04051744
133TRIB30.03951648
134PIM10.03082566
135PRKG10.03065428
136MARK30.02837817
137CSNK1D0.02118603
138STK110.02008342
139MAPK80.01564433
140PRKCA0.01520278
141PRKCB0.01492830
142MAP3K10.01347468
143CDK140.01117095
144CDK20.00985383
145CAMK2A0.00943315
146EGFR0.00519946
147RPS6KA3-0.0363653
148MAP2K2-0.0338917
149CDK4-0.0285085
150CDK1-0.0075073
151CSNK2A2-0.0063481
152PDGFRB-0.0021765
153PRKCD-0.0012123
154YES1-0.0005405

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.45905398
2Fatty acid biosynthesis_Homo sapiens_hsa000614.32825792
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.22053068
4Pyruvate metabolism_Homo sapiens_hsa006203.27840164
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22393483
6Olfactory transduction_Homo sapiens_hsa047403.09526433
7Linoleic acid metabolism_Homo sapiens_hsa005913.07808004
8Vitamin B6 metabolism_Homo sapiens_hsa007503.07131227
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80147226
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.70342490
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51195560
12Glucagon signaling pathway_Homo sapiens_hsa049222.44559753
13Propanoate metabolism_Homo sapiens_hsa006402.44331228
14Selenocompound metabolism_Homo sapiens_hsa004502.23683500
15Butanoate metabolism_Homo sapiens_hsa006502.18723817
16Glycerolipid metabolism_Homo sapiens_hsa005612.07191975
17Basal transcription factors_Homo sapiens_hsa030222.01273282
18Mineral absorption_Homo sapiens_hsa049782.00888871
19Fat digestion and absorption_Homo sapiens_hsa049751.99518452
20PPAR signaling pathway_Homo sapiens_hsa033201.86732601
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84984736
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77814871
23Phenylalanine metabolism_Homo sapiens_hsa003601.74773861
24Fructose and mannose metabolism_Homo sapiens_hsa000511.72882450
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.72580822
26Pentose phosphate pathway_Homo sapiens_hsa000301.58450707
27Allograft rejection_Homo sapiens_hsa053301.57871332
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55182622
29Autoimmune thyroid disease_Homo sapiens_hsa053201.53653330
30Type I diabetes mellitus_Homo sapiens_hsa049401.53173899
31Oocyte meiosis_Homo sapiens_hsa041141.52963972
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49966811
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.49889072
34Amphetamine addiction_Homo sapiens_hsa050311.48182692
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45460871
36Ether lipid metabolism_Homo sapiens_hsa005651.42557890
37Graft-versus-host disease_Homo sapiens_hsa053321.41641606
38Cardiac muscle contraction_Homo sapiens_hsa042601.34037176
39Fatty acid degradation_Homo sapiens_hsa000711.33091848
40Glutathione metabolism_Homo sapiens_hsa004801.32932509
41Carbon metabolism_Homo sapiens_hsa012001.32635043
42Dorso-ventral axis formation_Homo sapiens_hsa043201.31031456
43Fatty acid metabolism_Homo sapiens_hsa012121.26942795
44Arginine biosynthesis_Homo sapiens_hsa002201.23037389
45Arginine and proline metabolism_Homo sapiens_hsa003301.22860091
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21440013
47Fanconi anemia pathway_Homo sapiens_hsa034601.07590092
48Renin secretion_Homo sapiens_hsa049241.05623387
49Notch signaling pathway_Homo sapiens_hsa043301.05089502
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04829852
51Systemic lupus erythematosus_Homo sapiens_hsa053221.02264267
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.01311542
53Bile secretion_Homo sapiens_hsa049761.00575234
54Viral myocarditis_Homo sapiens_hsa054160.97891585
55Huntingtons disease_Homo sapiens_hsa050160.96397042
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95095794
57Antigen processing and presentation_Homo sapiens_hsa046120.93981339
58Purine metabolism_Homo sapiens_hsa002300.91361709
59mRNA surveillance pathway_Homo sapiens_hsa030150.88448365
60Sulfur metabolism_Homo sapiens_hsa009200.87368649
61Collecting duct acid secretion_Homo sapiens_hsa049660.86068134
62Thyroid hormone synthesis_Homo sapiens_hsa049180.85217252
63Renin-angiotensin system_Homo sapiens_hsa046140.85111353
64Hedgehog signaling pathway_Homo sapiens_hsa043400.84191338
65Influenza A_Homo sapiens_hsa051640.81130914
66Insulin secretion_Homo sapiens_hsa049110.80626311
67Arachidonic acid metabolism_Homo sapiens_hsa005900.80236090
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78431249
69Chemical carcinogenesis_Homo sapiens_hsa052040.78034607
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.77662716
71Retinol metabolism_Homo sapiens_hsa008300.77604661
72Phototransduction_Homo sapiens_hsa047440.74541437
73Tight junction_Homo sapiens_hsa045300.74032128
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72924343
75Estrogen signaling pathway_Homo sapiens_hsa049150.72787822
76Tyrosine metabolism_Homo sapiens_hsa003500.72729110
77Pancreatic secretion_Homo sapiens_hsa049720.71922697
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68590020
79Long-term potentiation_Homo sapiens_hsa047200.68338434
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68093050
81Biosynthesis of amino acids_Homo sapiens_hsa012300.65628096
82Protein digestion and absorption_Homo sapiens_hsa049740.65263188
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.64334920
84ABC transporters_Homo sapiens_hsa020100.61642738
85RNA transport_Homo sapiens_hsa030130.60866944
86Sulfur relay system_Homo sapiens_hsa041220.58186686
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55111531
88Acute myeloid leukemia_Homo sapiens_hsa052210.54386802
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53837260
90Alcoholism_Homo sapiens_hsa050340.53475970
91Salivary secretion_Homo sapiens_hsa049700.53218192
92Legionellosis_Homo sapiens_hsa051340.53163973
93Gastric acid secretion_Homo sapiens_hsa049710.52874170
94Inositol phosphate metabolism_Homo sapiens_hsa005620.52847296
95MAPK signaling pathway_Homo sapiens_hsa040100.51658751
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51433558
97Morphine addiction_Homo sapiens_hsa050320.51004830
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50579982
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47858575
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.47800927
101AMPK signaling pathway_Homo sapiens_hsa041520.47337890
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.46179893
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44119793
104Calcium signaling pathway_Homo sapiens_hsa040200.43955547
105Glutamatergic synapse_Homo sapiens_hsa047240.43195464
106ECM-receptor interaction_Homo sapiens_hsa045120.42961518
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40655025
108Endocytosis_Homo sapiens_hsa041440.40015626
109Choline metabolism in cancer_Homo sapiens_hsa052310.39875098
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39643508
111VEGF signaling pathway_Homo sapiens_hsa043700.38301636
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38064601
113Metabolic pathways_Homo sapiens_hsa011000.37776605
114N-Glycan biosynthesis_Homo sapiens_hsa005100.37537314
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.35211486
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.34669194
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32732093
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.31748941
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31711738
120Histidine metabolism_Homo sapiens_hsa003400.31333492
121Synaptic vesicle cycle_Homo sapiens_hsa047210.29729248
122Nicotine addiction_Homo sapiens_hsa050330.29718845
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29552599
124mTOR signaling pathway_Homo sapiens_hsa041500.28751211
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28473060
126Serotonergic synapse_Homo sapiens_hsa047260.28206153
127Taste transduction_Homo sapiens_hsa047420.26574460
128Nitrogen metabolism_Homo sapiens_hsa009100.26356371
129cAMP signaling pathway_Homo sapiens_hsa040240.26316846
130Salmonella infection_Homo sapiens_hsa051320.25973069
131Cholinergic synapse_Homo sapiens_hsa047250.25000958
132Cocaine addiction_Homo sapiens_hsa050300.23169881
133Oxytocin signaling pathway_Homo sapiens_hsa049210.22378114
134Pyrimidine metabolism_Homo sapiens_hsa002400.18166877
135Viral carcinogenesis_Homo sapiens_hsa052030.16775873
136Circadian entrainment_Homo sapiens_hsa047130.16678932
137HIF-1 signaling pathway_Homo sapiens_hsa040660.15077337
138Insulin resistance_Homo sapiens_hsa049310.12861083
139Vitamin digestion and absorption_Homo sapiens_hsa049770.12087397
140Basal cell carcinoma_Homo sapiens_hsa052170.10378841
141B cell receptor signaling pathway_Homo sapiens_hsa046620.09757236
142Type II diabetes mellitus_Homo sapiens_hsa049300.08287769

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