ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	9.74161239
2	acrosome assembly (GO:0001675)	9.23493857
3	sperm-egg recognition (GO:0035036)	8.99164451
4	reproduction (GO:0000003)	8.42427714
5	cell-cell recognition (GO:0009988)	8.10914808
6	motile cilium assembly (GO:0044458)	7.83995894
7	sperm motility (GO:0030317)	7.77841002
8	epithelial cilium movement (GO:0003351)	7.58022060
9	acrosome reaction (GO:0007340)	7.20206280
10	axonemal dynein complex assembly (GO:0070286)	7.08015452
11	binding of sperm to zona pellucida (GO:0007339)	7.06791265
12	spermatid development (GO:0007286)	6.99305785
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.29349605
14	cilium movement (GO:0003341)	6.25459194
15	single fertilization (GO:0007338)	5.97049440
16	male meiosis (GO:0007140)	5.26718988
17	microtubule depolymerization (GO:0007019)	4.98883397
18	piRNA metabolic process (GO:0034587)	4.91567665
19	regulation of cilium movement (GO:0003352)	4.77426320
20	calcium ion-dependent exocytosis (GO:0017156)	4.72232012
21	organic cation transport (GO:0015695)	4.65567743
22	cell recognition (GO:0008037)	4.63587440
23	fertilization (GO:0009566)	4.46345366
24	ventricular system development (GO:0021591)	4.33608401
25	sperm capacitation (GO:0048240)	4.29683166
26	polyketide metabolic process (GO:0030638)	4.29601662
27	doxorubicin metabolic process (GO:0044598)	4.29601662
28	daunorubicin metabolic process (GO:0044597)	4.29601662
29	synaptonemal complex organization (GO:0070193)	4.00617894
30	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.83505917
31	spermatogenesis (GO:0007283)	3.77647003
32	male gamete generation (GO:0048232)	3.76655467
33	protein localization to cilium (GO:0061512)	3.72624293
34	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.64098597
35	germ cell development (GO:0007281)	3.60898312
36	synaptonemal complex assembly (GO:0007130)	3.56320697
37	fat-soluble vitamin biosynthetic process (GO:0042362)	3.55548609
38	gamete generation (GO:0007276)	3.51770282
39	inositol phosphate-mediated signaling (GO:0048016)	3.48691359
40	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.37874402
41	regulation of inclusion body assembly (GO:0090083)	3.37325242
42	DNA methylation involved in gamete generation (GO:0043046)	3.32552866
43	male meiosis I (GO:0007141)	3.27052496
44	negative regulation of inclusion body assembly (GO:0090084)	3.21463640
45	glycerol metabolic process (GO:0006071)	3.16650666
46	spermatid nucleus differentiation (GO:0007289)	3.16073357
47	GTP biosynthetic process (GO:0006183)	3.15126034
48	intraciliary transport (GO:0042073)	3.08197531
49	regulation of meiosis I (GO:0060631)	3.06053259
50	alditol metabolic process (GO:0019400)	3.02526912
51	centriole assembly (GO:0098534)	2.99503306
52	glycerol ether metabolic process (GO:0006662)	2.97289501
53	atrial cardiac muscle cell action potential (GO:0086014)	2.92606393
54	chromosome organization involved in meiosis (GO:0070192)	2.89027672
55	centriole replication (GO:0007099)	2.84489194
56	left/right pattern formation (GO:0060972)	2.83536238
57	negative regulation of skeletal muscle tissue development (GO:0048642)	2.83488329
58	meiotic nuclear division (GO:0007126)	2.79326291
59	ether metabolic process (GO:0018904)	2.76326486
60	lactate metabolic process (GO:0006089)	2.75783342
61	UTP biosynthetic process (GO:0006228)	2.72431573
62	nucleoside diphosphate phosphorylation (GO:0006165)	2.71809692
63	multicellular organismal reproductive process (GO:0048609)	2.70974303
64	aminoglycoside antibiotic metabolic process (GO:0030647)	2.70952610
65	glutamate receptor signaling pathway (GO:0007215)	2.69778707
66	regulation of microtubule-based movement (GO:0060632)	2.65652432
67	UTP metabolic process (GO:0046051)	2.63599478
68	regulation of beta-amyloid formation (GO:1902003)	2.61983999
69	meiotic cell cycle (GO:0051321)	2.60048969
70	potassium ion export (GO:0071435)	2.59857684
71	synapsis (GO:0007129)	2.58560565
72	response to epinephrine (GO:0071871)	2.57779056
73	polyol catabolic process (GO:0046174)	2.57480312
74	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.56630598
75	ATP hydrolysis coupled proton transport (GO:0015991)	2.56483053
76	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.56483053
77	response to gravity (GO:0009629)	2.56452346
78	cellular ketone body metabolic process (GO:0046950)	2.55638082
79	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.53070372
80	cilium morphogenesis (GO:0060271)	2.53045166
81	cilium assembly (GO:0042384)	2.51545634
82	single strand break repair (GO:0000012)	2.50572129
83	cellular component assembly involved in morphogenesis (GO:0010927)	2.46690916
84	microtubule polymerization or depolymerization (GO:0031109)	2.45787169
85	cilium organization (GO:0044782)	2.45046795
86	fructose metabolic process (GO:0006000)	2.44731983
87	cellular response to epinephrine stimulus (GO:0071872)	2.43042197
88	visual behavior (GO:0007632)	2.41951365
89	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.40008606
90	cellular extravasation (GO:0045123)	2.37325029
91	meiosis I (GO:0007127)	2.37080536
92	phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	2.36471330
93	chaperone-mediated protein complex assembly (GO:0051131)	2.33831128
94	negative regulation of epidermal cell differentiation (GO:0045605)	2.33121477
95	axoneme assembly (GO:0035082)	2.32482817
96	* cell wall macromolecule catabolic process (GO:0016998)	14.6705823
97	* cell wall macromolecule metabolic process (GO:0044036)	14.6705823
98	fusion of sperm to egg plasma membrane (GO:0007342)	13.7681402
99	plasma membrane fusion (GO:0045026)	10.9530929
100	multicellular organism reproduction (GO:0032504)	10.5161517

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	5.50869016
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.57689096
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.83048449
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.69973315
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.66570578
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.62490316
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60526157
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.42996469
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.41090529
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.40551988
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.25544435
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11391655
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.10880446
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.03337682
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.99018027
16	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.94758134
17	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.88753140
18	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.88675939
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87352433
20	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.86834950
21	FUS_26573619_Chip-Seq_HEK293_Human	1.79591687
22	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.75438535
23	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.75407845
24	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.73947534
25	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.72801082
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70467310
27	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.68212096
28	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.67595503
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.65630747
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64396177
31	KDM2B_26808549_Chip-Seq_REH_Human	1.62954191
32	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.60453107
33	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.60376728
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59410747
35	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.57996473
36	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.56072193
37	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.55898091
38	P53_22387025_ChIP-Seq_ESCs_Mouse	1.52792878
39	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.51692584
40	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.50178635
41	P300_18555785_Chip-Seq_ESCs_Mouse	1.48555144
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48358156
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47451561
44	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.46962156
45	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.46923917
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45480649
47	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.45077335
48	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45074262
49	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.44409528
50	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.42996626
51	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.42038038
52	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.41880912
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41705035
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40293448
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40293448
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38556855
57	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.36854271
58	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35201101
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33402573
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.33369281
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33369281
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.33355564
63	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.32751588
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32360749
65	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.32081572
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.30894473
67	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.30782054
68	PU1_27457419_Chip-Seq_LIVER_Mouse	1.29497504
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29443353
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29275241
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28424358
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25934535
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24914155
74	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23749430
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23183625
76	P300_19829295_ChIP-Seq_ESCs_Human	1.22876857
77	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.22656734
78	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21037678
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18627724
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.18062119
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.16047136
82	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.14739775
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13326360
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13258760
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12583137
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11974897
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10884991
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.09136681
89	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.08373969
90	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07747831
91	AR_25329375_ChIP-Seq_VCAP_Human	1.07363314
92	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07039757
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.06508539
94	GF1_26923725_Chip-Seq_HPCs_Mouse	1.06306120
95	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05950161
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04124864
97	VDR_22108803_ChIP-Seq_LS180_Human	1.03864103
98	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.03456975
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03209713
100	STAT1_17558387_ChIP-Seq_HELA_Human	1.03136183

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.14635829
2	MP0008004_abnormal_stomach_pH	4.72758322
3	MP0003698_abnormal_male_reproductive	3.79975513
4	MP0002736_abnormal_nociception_after	3.57446365
5	MP0001929_abnormal_gametogenesis	3.24276106
6	MP0008877_abnormal_DNA_methylation	3.14865652
7	MP0001502_abnormal_circadian_rhythm	3.06883651
8	MP0001968_abnormal_touch/_nociception	2.94199420
9	MP0009046_muscle_twitch	2.40128440
10	MP0008872_abnormal_physiological_respon	2.11344529
11	MP0002837_dystrophic_cardiac_calcinosis	2.10249707
12	MP0001440_abnormal_grooming_behavior	2.07927973
13	MP0002161_abnormal_fertility/fecundity	2.00370645
14	MP0004859_abnormal_synaptic_plasticity	1.98801086
15	MP0002210_abnormal_sex_determination	1.93384838
16	MP0003329_amyloid_beta_deposits	1.88935771
17	MP0003635_abnormal_synaptic_transmissio	1.85627979
18	MP0001984_abnormal_olfaction	1.84401113
19	MP0003941_abnormal_skin_development	1.83904439
20	MP0005535_abnormal_body_temperature	1.75097044
21	MP0004233_abnormal_muscle_weight	1.73442519
22	MP0001145_abnormal_male_reproductive	1.72703547
23	MP0002734_abnormal_mechanical_nocicepti	1.70100252
24	MP0000653_abnormal_sex_gland	1.66571506
25	MP0009745_abnormal_behavioral_response	1.63593725
26	MP0005623_abnormal_meninges_morphology	1.62213045
27	MP0004215_abnormal_myocardial_fiber	1.61312723
28	MP0001486_abnormal_startle_reflex	1.61141525
29	MP0002064_seizures	1.60031415
30	MP0002102_abnormal_ear_morphology	1.57794049
31	MP0002063_abnormal_learning/memory/cond	1.56450754
32	MP0002127_abnormal_cardiovascular_syste	1.52373237
33	MP0003011_delayed_dark_adaptation	1.51566541
34	MP0002572_abnormal_emotion/affect_behav	1.48019165
35	MP0004484_altered_response_of	1.46754237
36	MP0001485_abnormal_pinna_reflex	1.44942143
37	MP0005551_abnormal_eye_electrophysiolog	1.44635293
38	MP0004264_abnormal_extraembryonic_tissu	1.41703881
39	MP0001348_abnormal_lacrimal_gland	1.40766024
40	MP0002733_abnormal_thermal_nociception	1.35500096
41	MP0004742_abnormal_vestibular_system	1.35484739
42	MP0000462_abnormal_digestive_system	1.34189002
43	MP0002254_reproductive_system_inflammat	1.29535603
44	MP0002735_abnormal_chemical_nociception	1.26551972
45	MP0002557_abnormal_social/conspecific_i	1.23114730
46	MP0004270_analgesia	1.20959563
47	MP0000751_myopathy	1.17808635
48	MP0005365_abnormal_bile_salt	1.16707513
49	MP0001501_abnormal_sleep_pattern	1.14220598
50	MP0002272_abnormal_nervous_system	1.13606206
51	MP0001970_abnormal_pain_threshold	1.12385913
52	MP0005646_abnormal_pituitary_gland	1.10101563
53	MP0002067_abnormal_sensory_capabilities	1.09634238
54	MP0003880_abnormal_central_pattern	1.07658425
55	MP0001765_abnormal_ion_homeostasis	1.04714908
56	MP0002249_abnormal_larynx_morphology	1.02025976
57	MP0008875_abnormal_xenobiotic_pharmacok	1.00966028
58	MP0000566_synostosis	0.99159292
59	MP0004134_abnormal_chest_morphology	0.96858192
60	MP0000026_abnormal_inner_ear	0.89514192
61	MP0005647_abnormal_sex_gland	0.89171019
62	MP0006276_abnormal_autonomic_nervous	0.88860070
63	MP0003879_abnormal_hair_cell	0.86422092
64	MP0000604_amyloidosis	0.85459520
65	MP0004858_abnormal_nervous_system	0.85236097
66	MP0001963_abnormal_hearing_physiology	0.84288727
67	MP0009780_abnormal_chondrocyte_physiolo	0.82558440
68	MP0002066_abnormal_motor_capabilities/c	0.81886138
69	MP0006292_abnormal_olfactory_placode	0.81371041
70	MP0005386_behavior/neurological_phenoty	0.81006691
71	MP0004924_abnormal_behavior	0.81006691
72	MP0003183_abnormal_peptide_metabolism	0.80867559
73	MP0004883_abnormal_blood_vessel	0.79980458
74	MP0002282_abnormal_trachea_morphology	0.79070593
75	MP0002160_abnormal_reproductive_system	0.78869503
76	MP0002139_abnormal_hepatobiliary_system	0.78768853
77	MP0003690_abnormal_glial_cell	0.76811305
78	MP0005381_digestive/alimentary_phenotyp	0.75065447
79	MP0005253_abnormal_eye_physiology	0.74860287
80	MP0002069_abnormal_eating/drinking_beha	0.74271610
81	MP0005379_endocrine/exocrine_gland_phen	0.73932122
82	MP0003137_abnormal_impulse_conducting	0.71896969
83	MP0001986_abnormal_taste_sensitivity	0.71769078
84	MP0001664_abnormal_digestion	0.71106048
85	MP0009697_abnormal_copulation	0.71077413
86	MP0005165_increased_susceptibility_to	0.69404800
87	MP0002132_abnormal_respiratory_system	0.68868865
88	MP0002653_abnormal_ependyma_morphology	0.67608310
89	MP0005310_abnormal_salivary_gland	0.67374543
90	MP0002928_abnormal_bile_duct	0.66676974
91	MP0005499_abnormal_olfactory_system	0.65874140
92	MP0005394_taste/olfaction_phenotype	0.65874140
93	MP0001529_abnormal_vocalization	0.62690196
94	MP0003959_abnormal_lean_body	0.61476614
95	MP0002876_abnormal_thyroid_physiology	0.60745216
96	MP0001905_abnormal_dopamine_level	0.60578983
97	MP0001663_abnormal_digestive_system	0.60431043
98	MP0003787_abnormal_imprinting	0.59895934
99	MP0004019_abnormal_vitamin_homeostasis	0.56974219
100	MP0002234_abnormal_pharynx_morphology	0.56700296

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	7.38695589
2	Abnormal respiratory motile cilium morphology (HP:0005938)	7.35306207
3	Abnormal respiratory epithelium morphology (HP:0012253)	7.35306207
4	Abnormal ciliary motility (HP:0012262)	6.66628605
5	Rhinitis (HP:0012384)	5.96633004
6	Chronic bronchitis (HP:0004469)	5.62726992
7	Ventricular fibrillation (HP:0001663)	4.06070937
8	Infertility (HP:0000789)	3.86756452
9	Focal motor seizures (HP:0011153)	3.84996420
10	Nasal polyposis (HP:0100582)	3.81214060
11	Renal cortical cysts (HP:0000803)	3.43703879
12	Medial flaring of the eyebrow (HP:0010747)	3.36395549
13	Bronchiectasis (HP:0002110)	3.23926062
14	Bronchitis (HP:0012387)	3.17705943
15	Gait imbalance (HP:0002141)	3.13654710
16	Congenital primary aphakia (HP:0007707)	3.02916493
17	Abnormality of the nasal mucosa (HP:0000433)	2.95499482
18	Nephronophthisis (HP:0000090)	2.92532397
19	Bundle branch block (HP:0011710)	2.68242133
20	Abnormality of renal resorption (HP:0011038)	2.63040465
21	Widely patent fontanelles and sutures (HP:0004492)	2.62736743
22	Generalized aminoaciduria (HP:0002909)	2.61179208
23	Hepatic necrosis (HP:0002605)	2.60860487
24	Recurrent sinusitis (HP:0011108)	2.60519247
25	Abnormality of the renal cortex (HP:0011035)	2.60089651
26	Cholecystitis (HP:0001082)	2.59616117
27	Abnormal gallbladder physiology (HP:0012438)	2.59616117
28	Cerebellar dysplasia (HP:0007033)	2.54834510
29	Supernumerary spleens (HP:0009799)	2.54148959
30	Nephrogenic diabetes insipidus (HP:0009806)	2.51437231
31	Visual hallucinations (HP:0002367)	2.51241701
32	Neurofibrillary tangles (HP:0002185)	2.33621534
33	Tubulointerstitial nephritis (HP:0001970)	2.30198779
34	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.28722383
35	Abnormality of the renal medulla (HP:0100957)	2.27615031
36	Vaginal atresia (HP:0000148)	2.23888467
37	Proximal tubulopathy (HP:0000114)	2.22488084
38	Male infertility (HP:0003251)	2.22348418
39	Genital tract atresia (HP:0001827)	2.20653698
40	Diplopia (HP:0000651)	2.18760952
41	Abnormality of binocular vision (HP:0011514)	2.18760952
42	Type II lissencephaly (HP:0007260)	2.17341319
43	Cerebral inclusion bodies (HP:0100314)	2.14795322
44	Polygenic inheritance (HP:0010982)	2.12352494
45	Chronic sinusitis (HP:0011109)	2.12004626
46	Tongue fasciculations (HP:0001308)	2.05212929
47	Hypoglycemic coma (HP:0001325)	2.01869931
48	Impaired smooth pursuit (HP:0007772)	2.01015869
49	Vascular calcification (HP:0004934)	2.00385654
50	Hemiparesis (HP:0001269)	2.00351381
51	Absent/shortened dynein arms (HP:0200106)	10.3647154
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.3647154
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.1925732
54	Epileptic encephalopathy (HP:0200134)	1.96529508
55	Abnormality of the costochondral junction (HP:0000919)	1.96065037
56	Congenital sensorineural hearing impairment (HP:0008527)	1.95560101
57	Hepatocellular necrosis (HP:0001404)	1.94610445
58	Poor coordination (HP:0002370)	1.93213533
59	Abnormality of ocular smooth pursuit (HP:0000617)	1.92087465
60	Muscle fibrillation (HP:0010546)	1.91987368
61	Limb ataxia (HP:0002070)	1.90515701
62	Decreased muscle mass (HP:0003199)	1.90329948
63	Methylmalonic acidemia (HP:0002912)	1.88375071
64	Thin bony cortex (HP:0002753)	1.88086112
65	Abnormality of the neuromuscular junction (HP:0003398)	1.87399577
66	Fatigable weakness (HP:0003473)	1.87399577
67	Pachygyria (HP:0001302)	1.83618930
68	Heart block (HP:0012722)	1.83118666
69	Molar tooth sign on MRI (HP:0002419)	1.80683824
70	Abnormality of midbrain morphology (HP:0002418)	1.80683824
71	Cardiovascular calcification (HP:0011915)	1.79937518
72	Recurrent otitis media (HP:0000403)	1.76794108
73	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76514726
74	Dicarboxylic aciduria (HP:0003215)	1.76514726
75	Methylmalonic aciduria (HP:0012120)	1.74797360
76	Type 2 muscle fiber atrophy (HP:0003554)	1.73186309
77	Broad foot (HP:0001769)	1.70731644
78	Bile duct proliferation (HP:0001408)	1.70546941
79	Abnormal biliary tract physiology (HP:0012439)	1.70546941
80	Left ventricular hypertrophy (HP:0001712)	1.70023541
81	Decreased central vision (HP:0007663)	1.69438365
82	Abnormal spermatogenesis (HP:0008669)	1.69003049
83	Poor suck (HP:0002033)	1.68516434
84	Opisthotonus (HP:0002179)	1.67902739
85	Aplasia/Hypoplasia of the lens (HP:0008063)	1.65602283
86	Delayed epiphyseal ossification (HP:0002663)	1.62875871
87	Impulsivity (HP:0100710)	1.62423548
88	Enlarged epiphyses (HP:0010580)	1.62419968
89	Abnormal atrioventricular conduction (HP:0005150)	1.61962747
90	Generalized muscle weakness (HP:0003324)	1.61025093
91	Abnormality of saccadic eye movements (HP:0000570)	1.59252698
92	Recurrent bronchitis (HP:0002837)	1.54358577
93	Fair hair (HP:0002286)	1.53207378
94	Hyperphosphatemia (HP:0002905)	1.52210367
95	Focal seizures (HP:0007359)	1.51306587
96	Abnormal EKG (HP:0003115)	1.50871627
97	Prolonged QT interval (HP:0001657)	1.50613242
98	Azoospermia (HP:0000027)	1.49679553
99	Buphthalmos (HP:0000557)	1.47032330
100	Syncope (HP:0001279)	1.44380970

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	6.02318098
2	PDK3	6.02318098
3	MAP3K6	4.68786156
4	RIPK4	3.76698271
5	PDK2	3.65123913
6	BMPR2	2.50067124
7	MAP2K4	2.42071617
8	EPHA4	2.28091942
9	MAP2K6	2.14347678
10	MAP3K12	2.11152359
11	PNCK	2.08715983
12	FRK	2.05069039
13	MAP2K3	1.89686220
14	MAP3K9	1.89535114
15	PBK	1.82288936
16	RIPK1	1.79746031
17	AKT3	1.77208695
18	LMTK2	1.64979611
19	PTK2B	1.61379023
20	MINK1	1.60246808
21	NTRK3	1.57970482
22	STK39	1.57518122
23	MUSK	1.51320045
24	PRKD2	1.38849093
25	ADRBK1	1.32339313
26	ADRBK2	1.30546165
27	PRKCG	1.23449110
28	DAPK2	1.22182550
29	OBSCN	1.20088433
30	MYLK	1.15136706
31	TESK1	1.13571535
32	TNIK	1.10566910
33	CDK8	1.04588349
34	CCNB1	1.03275479
35	WNK4	1.02818491
36	CASK	0.98305760
37	TTK	0.97216131
38	NME1	0.90373191
39	PRKCH	0.84506285
40	FES	0.84250947
41	ZAP70	0.80790941
42	NTRK2	0.79296578
43	PLK2	0.78381722
44	TYRO3	0.71683274
45	INSRR	0.70183841
46	MAP3K4	0.69367595
47	CAMK2A	0.69328818
48	PRKD3	0.68018433
49	IRAK1	0.67684372
50	MAP2K7	0.66668664
51	GRK6	0.65834436
52	STK38	0.63225419
53	MOS	0.61528293
54	PIK3CG	0.61397194
55	RET	0.60956518
56	DAPK1	0.58662964
57	GRK5	0.56667334
58	PRKCE	0.55349887
59	TAOK3	0.54359612
60	PLK4	0.51568811
61	SYK	0.51376549
62	PKN1	0.50982004
63	PDK1	0.50491159
64	NUAK1	0.49002048
65	PRKCA	0.46433859
66	MAP3K13	0.46375665
67	PDPK1	0.45483112
68	TIE1	0.43402938
69	MAP3K5	0.43137069
70	CAMK1G	0.43039822
71	PRKACA	0.42608701
72	BUB1	0.42017089
73	BRAF	0.41438308
74	OXSR1	0.40802195
75	ICK	0.38571924
76	MARK1	0.37102409
77	PRKG1	0.37016529
78	CHEK2	0.34309863
79	ROCK2	0.34031407
80	PAK4	0.30544881
81	CDK12	0.29639497
82	PRKCB	0.28239253
83	CLK1	0.26992943
84	PASK	0.24058498
85	PRKACG	0.23348865
86	WNK1	0.22570468
87	CDK5	0.21991535
88	CSNK1D	0.21122109
89	CDK15	0.20906292
90	CAMK1	0.20840428
91	HCK	0.19694059
92	CDK18	0.19100474
93	GRK1	0.18704290
94	PAK1	0.18555128
95	PRKD1	0.17890156
96	FYN	0.17606971
97	CSNK1G2	0.17343602
98	ERBB2	0.17044493
99	CDK11A	0.16637116
100	PAK6	0.15930357

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	2.89173240
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.66525463
3	Nicotine addiction_Homo sapiens_hsa05033	2.60119511
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59273423
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.40666844
6	Pentose phosphate pathway_Homo sapiens_hsa00030	2.40550667
7	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.37509680
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.35624245
9	Pyruvate metabolism_Homo sapiens_hsa00620	2.29470352
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.19462787
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19123699
12	Huntingtons disease_Homo sapiens_hsa05016	2.17697155
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.13476835
14	Collecting duct acid secretion_Homo sapiens_hsa04966	2.09160857
15	Cardiac muscle contraction_Homo sapiens_hsa04260	2.02862203
16	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.88398716
17	Amphetamine addiction_Homo sapiens_hsa05031	1.86156120
18	Parkinsons disease_Homo sapiens_hsa05012	1.74292767
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71244826
20	Gastric acid secretion_Homo sapiens_hsa04971	1.70656945
21	Alzheimers disease_Homo sapiens_hsa05010	1.66863325
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.65401786
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.60112886
24	Calcium signaling pathway_Homo sapiens_hsa04020	1.57912521
25	Long-term potentiation_Homo sapiens_hsa04720	1.56577076
26	Circadian entrainment_Homo sapiens_hsa04713	1.51377436
27	Renin secretion_Homo sapiens_hsa04924	1.49057698
28	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.40650318
29	Salivary secretion_Homo sapiens_hsa04970	1.40109723
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39726789
31	Morphine addiction_Homo sapiens_hsa05032	1.33663508
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29347216
33	Olfactory transduction_Homo sapiens_hsa04740	1.28673909
34	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.27737594
35	Insulin secretion_Homo sapiens_hsa04911	1.27326081
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.27305149
37	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.18854744
38	Carbon metabolism_Homo sapiens_hsa01200	1.18751691
39	Glucagon signaling pathway_Homo sapiens_hsa04922	1.17176219
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.15584832
41	Taste transduction_Homo sapiens_hsa04742	1.12757853
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.12682763
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.11931374
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.11025319
45	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.02677142
46	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.02607252
47	GABAergic synapse_Homo sapiens_hsa04727	1.01314047
48	Oocyte meiosis_Homo sapiens_hsa04114	0.99207254
49	African trypanosomiasis_Homo sapiens_hsa05143	0.97410067
50	Fatty acid degradation_Homo sapiens_hsa00071	0.97142286
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96863244
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.96552294
53	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.96292714
54	Long-term depression_Homo sapiens_hsa04730	0.92696773
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.90744299
56	Bile secretion_Homo sapiens_hsa04976	0.88118021
57	PPAR signaling pathway_Homo sapiens_hsa03320	0.85297222
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.83654507
59	Mineral absorption_Homo sapiens_hsa04978	0.82455365
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.79526496
61	Serotonergic synapse_Homo sapiens_hsa04726	0.77125462
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76237356
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.73634550
64	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72806978
65	Metabolic pathways_Homo sapiens_hsa01100	0.72322991
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68250167
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67683311
68	Butanoate metabolism_Homo sapiens_hsa00650	0.65540193
69	Phototransduction_Homo sapiens_hsa04744	0.65005358
70	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.64834083
71	Cocaine addiction_Homo sapiens_hsa05030	0.63344673
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61541063
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60185904
74	Fatty acid elongation_Homo sapiens_hsa00062	0.59629060
75	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.58952307
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55991967
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52056154
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.50554245
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48278251
80	Sulfur relay system_Homo sapiens_hsa04122	0.47756326
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46325869
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.45170822
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44666650
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43992655
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42135576
86	Cholinergic synapse_Homo sapiens_hsa04725	0.41476522
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40511386
88	Purine metabolism_Homo sapiens_hsa00230	0.40043058
89	Estrogen signaling pathway_Homo sapiens_hsa04915	0.40011178
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38297034
91	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38285269
92	Pancreatic secretion_Homo sapiens_hsa04972	0.38039591
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37638650
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37115261
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36944537
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35852988
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33144514
98	Glutathione metabolism_Homo sapiens_hsa00480	0.32770084
99	GnRH signaling pathway_Homo sapiens_hsa04912	0.32635409
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31885102

SPACA5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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