SPACA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.85840707
2behavioral response to nicotine (GO:0035095)6.02364933
3kynurenine metabolic process (GO:0070189)4.38948568
4tryptophan catabolic process (GO:0006569)4.29707100
5indole-containing compound catabolic process (GO:0042436)4.29707100
6indolalkylamine catabolic process (GO:0046218)4.29707100
7fucose catabolic process (GO:0019317)4.14659979
8L-fucose metabolic process (GO:0042354)4.14659979
9L-fucose catabolic process (GO:0042355)4.14659979
10cellular ketone body metabolic process (GO:0046950)4.06601286
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.00513780
12cellular response to ATP (GO:0071318)3.92283717
13nephron tubule morphogenesis (GO:0072078)3.67967683
14nephron epithelium morphogenesis (GO:0072088)3.67967683
15head development (GO:0060322)3.60961627
16ketone body metabolic process (GO:1902224)3.58209590
17negative regulation of mast cell activation (GO:0033004)3.50284368
18indolalkylamine metabolic process (GO:0006586)3.48959850
19neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.45174262
20protein polyglutamylation (GO:0018095)3.42660463
21tryptophan metabolic process (GO:0006568)3.42490190
22phosphatidylinositol acyl-chain remodeling (GO:0036149)3.36546261
23multicellular organism reproduction (GO:0032504)3.31434489
24amine catabolic process (GO:0009310)3.30368397
25cellular biogenic amine catabolic process (GO:0042402)3.30368397
26neuronal action potential (GO:0019228)3.25234786
27sperm motility (GO:0030317)3.24569101
28epithelial cilium movement (GO:0003351)3.22380121
29negative regulation of telomere maintenance (GO:0032205)3.21868317
30piRNA metabolic process (GO:0034587)3.20890951
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.20747363
32axon extension involved in axon guidance (GO:0048846)3.20747363
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17130802
34locomotory exploration behavior (GO:0035641)3.12083073
35DNA deamination (GO:0045006)3.11202183
36regulation of action potential (GO:0098900)3.11079564
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.09053188
38cornea development in camera-type eye (GO:0061303)3.06299908
39platelet dense granule organization (GO:0060155)3.06099857
40axoneme assembly (GO:0035082)3.02511282
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.00895429
42detection of light stimulus involved in sensory perception (GO:0050962)2.99095849
43detection of light stimulus involved in visual perception (GO:0050908)2.99095849
44indole-containing compound metabolic process (GO:0042430)2.98153460
45NAD biosynthetic process (GO:0009435)2.96920565
46gamma-aminobutyric acid transport (GO:0015812)2.96292585
47primary amino compound metabolic process (GO:1901160)2.93393971
48preassembly of GPI anchor in ER membrane (GO:0016254)2.91121451
49positive regulation of fatty acid transport (GO:2000193)2.89170404
50cilium or flagellum-dependent cell motility (GO:0001539)2.88319295
51lateral sprouting from an epithelium (GO:0060601)2.87873776
52alanine transport (GO:0032328)2.86452219
53vocalization behavior (GO:0071625)2.84189934
54regulation of cilium movement (GO:0003352)2.83656227
55negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82295727
56protein complex biogenesis (GO:0070271)2.80489632
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80264577
58mitochondrial respiratory chain complex I assembly (GO:0032981)2.80264577
59NADH dehydrogenase complex assembly (GO:0010257)2.80264577
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79030038
61positive regulation of prostaglandin secretion (GO:0032308)2.78901673
62extracellular negative regulation of signal transduction (GO:1900116)2.76303984
63extracellular regulation of signal transduction (GO:1900115)2.76303984
64sequestering of extracellular ligand from receptor (GO:0035581)2.74563238
65regulation of axon extension involved in axon guidance (GO:0048841)2.73214740
66cilium morphogenesis (GO:0060271)2.71736251
67renal tubule morphogenesis (GO:0061333)2.71136629
68nonmotile primary cilium assembly (GO:0035058)2.70556420
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70544049
70regulation of axon guidance (GO:1902667)2.69928608
71cerebellar Purkinje cell differentiation (GO:0021702)2.69413175
72positive regulation of triglyceride biosynthetic process (GO:0010867)2.68641909
73sulfation (GO:0051923)2.68492062
74urinary tract smooth muscle contraction (GO:0014848)2.67352553
75metanephric mesenchyme development (GO:0072075)2.67254855
76behavioral response to ethanol (GO:0048149)2.65406449
77cAMP catabolic process (GO:0006198)2.65114056
78reflex (GO:0060004)2.64224100
79DNA methylation involved in gamete generation (GO:0043046)2.63783993
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.63666231
81synaptic transmission, cholinergic (GO:0007271)2.62535528
82mitochondrial respiratory chain complex assembly (GO:0033108)2.62406073
83cilium movement (GO:0003341)2.62164233
84organic cation transport (GO:0015695)2.61668099
85centriole replication (GO:0007099)2.61413469
86axonal fasciculation (GO:0007413)2.60688926
87negative regulation of axon guidance (GO:1902668)2.60323755
88exploration behavior (GO:0035640)2.60304354
89negative regulation of reactive oxygen species metabolic process (GO:2000378)2.60193591
90regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60088499
91phosphatidylserine acyl-chain remodeling (GO:0036150)2.58467759
92acrosome reaction (GO:0007340)2.58152174
93protein-cofactor linkage (GO:0018065)2.57885777
94water-soluble vitamin biosynthetic process (GO:0042364)2.57000557
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56418715
96parturition (GO:0007567)2.55952370
97positive regulation of icosanoid secretion (GO:0032305)2.53555790
98serotonin metabolic process (GO:0042428)2.52729019
99regulation of microtubule-based movement (GO:0060632)2.52574906
100glutamate receptor signaling pathway (GO:0007215)2.52521038
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.50692477
102regulation of hippo signaling (GO:0035330)2.50652841
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49615213
104basic amino acid transport (GO:0015802)2.49541745
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.49498355
106positive regulation of action potential (GO:0045760)2.49197736
107peristalsis (GO:0030432)2.48754521
108postsynaptic membrane organization (GO:0001941)2.48436764
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48132634
110retinal cone cell development (GO:0046549)2.47943529
111inner ear receptor stereocilium organization (GO:0060122)2.47924604
112protein import into peroxisome matrix (GO:0016558)2.47131595
113regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47111331
114phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.46683696
115respiratory chain complex IV assembly (GO:0008535)2.46138383
116spinal cord motor neuron differentiation (GO:0021522)2.45917615
117cilium organization (GO:0044782)2.45816337
118proline transport (GO:0015824)2.45641133
119rhodopsin mediated signaling pathway (GO:0016056)2.45593183
120glomerular filtration (GO:0003094)2.44627934
121regulation of triglyceride biosynthetic process (GO:0010866)2.44472669
122synaptic transmission, glutamatergic (GO:0035249)2.44441239
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44252091
124protein localization to cilium (GO:0061512)2.43867789
125central nervous system projection neuron axonogenesis (GO:0021952)2.43523103
126regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43118432
127endoderm formation (GO:0001706)2.42335499
128positive regulation of defense response to virus by host (GO:0002230)2.41662411
129regulation of mesoderm development (GO:2000380)2.41558899
130kidney mesenchyme development (GO:0072074)2.41087346
131histone H3-K4 trimethylation (GO:0080182)2.40731761
132mannosylation (GO:0097502)2.39859345
133chondrocyte proliferation (GO:0035988)2.39371100
134mesenchymal cell differentiation (GO:0048762)2.36449288
135membrane depolarization during action potential (GO:0086010)2.34840283
136calcium ion import (GO:0070509)2.32386740
137cell proliferation involved in metanephros development (GO:0072203)2.31769545
138bone trabecula formation (GO:0060346)2.30864009
139presynaptic membrane assembly (GO:0097105)2.30778001
140dendritic spine morphogenesis (GO:0060997)2.30668018
141regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.30342191
142regulation of glutamate receptor signaling pathway (GO:1900449)2.29645784
143ganglion development (GO:0061548)2.29411583
144nucleus localization (GO:0051647)2.28917942
145neuron recognition (GO:0008038)2.27909339
146chondrocyte development (GO:0002063)2.27806398
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27711233
148dendritic spine organization (GO:0097061)2.27172089
149negative regulation of systemic arterial blood pressure (GO:0003085)2.27088098
150positive regulation of smoothened signaling pathway (GO:0045880)2.26782249
151dendrite morphogenesis (GO:0048813)2.26394566
152mesenchymal cell development (GO:0014031)2.26262256
153mesenchymal-epithelial cell signaling (GO:0060638)2.25774844
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.25532476
155renal filtration (GO:0097205)2.24290309
156interkinetic nuclear migration (GO:0022027)2.23683599
157heart morphogenesis (GO:0003007)2.23042778
158regulation of mesenchymal cell proliferation (GO:0010464)2.22973079
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.22565252
160regulation of translation, ncRNA-mediated (GO:0045974)2.22565252
161negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.22565252
162G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.22167454
163paraxial mesoderm development (GO:0048339)2.20905736
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.19677461
165positive regulation of mesenchymal cell proliferation (GO:0002053)2.18366420
166regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17988778
167craniofacial suture morphogenesis (GO:0097094)2.15775282
168negative regulation of stem cell proliferation (GO:2000647)2.15087211
169negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.14771197
170neural crest cell development (GO:0014032)2.14635823
171establishment of nucleus localization (GO:0040023)2.13228291
172neuronal ion channel clustering (GO:0045161)2.12497876
173negative chemotaxis (GO:0050919)2.10844816
174cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.10709807
175somite development (GO:0061053)2.10349675
176regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.10345190
177negative regulation of chondrocyte differentiation (GO:0032331)2.09802206
178cell communication by electrical coupling (GO:0010644)2.08964428
179negative regulation of catenin import into nucleus (GO:0035414)2.08612422
180negative regulation of keratinocyte proliferation (GO:0010839)2.07632192
181exocrine pancreas development (GO:0031017)2.07088129
182mesenchymal cell differentiation involved in renal system development (GO:2001012)2.06299659
183mesenchymal cell differentiation involved in kidney development (GO:0072161)2.06299659
184startle response (GO:0001964)2.06110075
185artery development (GO:0060840)2.06057690
186neuron-neuron synaptic transmission (GO:0007270)2.05664387
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.05584068
188embryonic appendage morphogenesis (GO:0035113)2.05326822
189embryonic limb morphogenesis (GO:0030326)2.05326822
190auditory behavior (GO:0031223)2.05210167
191positive regulation of heat generation (GO:0031652)2.05164426
192neuron cell-cell adhesion (GO:0007158)2.04845220
193response to auditory stimulus (GO:0010996)2.03701204
194palate development (GO:0060021)2.03643730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.63000616
2GBX2_23144817_ChIP-Seq_PC3_Human3.37034543
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30136762
4VDR_22108803_ChIP-Seq_LS180_Human3.02657087
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42863396
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24121531
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20947992
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.17550986
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16811612
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13735168
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.11604312
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10233489
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08216726
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08216726
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04241331
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.02916444
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92768486
18IGF1R_20145208_ChIP-Seq_DFB_Human1.92760343
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90675143
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89989152
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89079099
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87079429
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84194129
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82293254
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.79362100
26ER_23166858_ChIP-Seq_MCF-7_Human1.77644251
27SMAD4_21799915_ChIP-Seq_A2780_Human1.77199400
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74868738
29DROSHA_22980978_ChIP-Seq_HELA_Human1.72564746
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71091393
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.66637334
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.65794201
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63476589
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62563241
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62424268
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61398207
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.60244511
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59661308
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59139643
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58675181
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57412442
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.56996450
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.56351673
44P300_19829295_ChIP-Seq_ESCs_Human1.55932438
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55072723
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54447576
47IRF1_19129219_ChIP-ChIP_H3396_Human1.53916695
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51743785
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50314184
50TP53_22573176_ChIP-Seq_HFKS_Human1.49667482
51TP53_16413492_ChIP-PET_HCT116_Human1.48117696
52ERA_21632823_ChIP-Seq_H3396_Human1.47534497
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46845604
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45496654
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45421606
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43904203
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.42809990
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41384798
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.41384798
60TP53_18474530_ChIP-ChIP_U2OS_Human1.41267014
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40606408
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39648012
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38404792
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36586280
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36041989
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35241309
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34380596
68AR_21572438_ChIP-Seq_LNCaP_Human1.34042353
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33854983
70TAF15_26573619_Chip-Seq_HEK293_Human1.33781978
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.33155449
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.32695242
73STAT3_23295773_ChIP-Seq_U87_Human1.32391210
74CBP_20019798_ChIP-Seq_JUKART_Human1.31766890
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31766890
76TAF2_19829295_ChIP-Seq_ESCs_Human1.31663141
77HOXB7_26014856_ChIP-Seq_BT474_Human1.31141821
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.31068318
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30846119
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30353978
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30147095
82AHR_22903824_ChIP-Seq_MCF-7_Human1.29169006
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.28867645
84FUS_26573619_Chip-Seq_HEK293_Human1.28212171
85NANOG_20526341_ChIP-Seq_ESCs_Human1.27355296
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26022217
87BCAT_22108803_ChIP-Seq_LS180_Human1.25937614
88AR_25329375_ChIP-Seq_VCAP_Human1.24746894
89NANOG_19829295_ChIP-Seq_ESCs_Human1.24654213
90SOX2_19829295_ChIP-Seq_ESCs_Human1.24654213
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23156760
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22238478
93MYC_19829295_ChIP-Seq_ESCs_Human1.22026718
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21678978
95OCT4_20526341_ChIP-Seq_ESCs_Human1.21282314
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21171871
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.20992462
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20913442
99TCF4_23295773_ChIP-Seq_U87_Human1.20676158
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.20589910
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19605586
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19605586
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.19457924
104MYC_18940864_ChIP-ChIP_HL60_Human1.17910796
105RUNX2_22187159_ChIP-Seq_PCA_Human1.17701461
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17483753
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.16786214
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16361380
109NCOR_22424771_ChIP-Seq_293T_Human1.16277370
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15249193
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.14859522
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14707090
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.14681339
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13609780
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13409090
116AR_19668381_ChIP-Seq_PC3_Human1.12733628
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12667521
118AR_20517297_ChIP-Seq_VCAP_Human1.12659835
119REST_21632747_ChIP-Seq_MESCs_Mouse1.11782776
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.10919526
121P53_22387025_ChIP-Seq_ESCs_Mouse1.09399221
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09346074
123TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09014517
124TCF4_18268006_ChIP-ChIP_LS174T_Human1.08457387
125RNF2_27304074_Chip-Seq_NSC_Mouse1.08280180
126P53_21459846_ChIP-Seq_SAOS-2_Human1.07917784
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07506447
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06871870
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06363908
130EWS_26573619_Chip-Seq_HEK293_Human1.05647478
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05118973
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.04860843
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04653472
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.04472045
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04309979
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.03966887
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03966541
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03861282
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03158496
140AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02407909
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01981624
142SMAD3_21741376_ChIP-Seq_HESCs_Human1.01966737
143ZNF274_21170338_ChIP-Seq_K562_Hela1.01588910
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01174720
145NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00962977
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00962977
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00620825
148NFE2_27457419_Chip-Seq_LIVER_Mouse1.00546774
149IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00485844
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.99587270
151TCF4_22108803_ChIP-Seq_LS180_Human0.98791016
152FOXH1_21741376_ChIP-Seq_ESCs_Human0.98669878
153RAC3_21632823_ChIP-Seq_H3396_Human0.97742235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.99054443
2MP0004859_abnormal_synaptic_plasticity3.29923097
3MP0000566_synostosis2.89300855
4MP0000569_abnormal_digit_pigmentation2.85370326
5MP0003136_yellow_coat_color2.69704694
6MP0003195_calcinosis2.68454774
7MP0003121_genomic_imprinting2.47764588
8MP0003646_muscle_fatigue2.45689304
9MP0005551_abnormal_eye_electrophysiolog2.38838480
10MP0003787_abnormal_imprinting2.31395010
11MP0008875_abnormal_xenobiotic_pharmacok2.30363306
12MP0001986_abnormal_taste_sensitivity2.26100834
13MP0003385_abnormal_body_wall2.24719468
14MP0005171_absent_coat_pigmentation2.19645171
15MP0003011_delayed_dark_adaptation2.10159083
16MP0005410_abnormal_fertilization2.09825681
17MP0001299_abnormal_eye_distance/2.06819246
18MP0002653_abnormal_ependyma_morphology2.04586108
19MP0005503_abnormal_tendon_morphology2.04270316
20MP0009250_abnormal_appendicular_skeleto1.98522211
21MP0004885_abnormal_endolymph1.97222911
22MP0008872_abnormal_physiological_respon1.97103701
23MP0004133_heterotaxia1.88745024
24MP0002837_dystrophic_cardiac_calcinosis1.88623524
25MP0009046_muscle_twitch1.81960778
26MP0002938_white_spotting1.81810527
27MP0005377_hearing/vestibular/ear_phenot1.80878076
28MP0003878_abnormal_ear_physiology1.80878076
29MP0009780_abnormal_chondrocyte_physiolo1.75863113
30MP0000049_abnormal_middle_ear1.75386806
31MP0006072_abnormal_retinal_apoptosis1.75056681
32MP0002876_abnormal_thyroid_physiology1.73612498
33MP0004043_abnormal_pH_regulation1.70833886
34MP0001485_abnormal_pinna_reflex1.68698155
35MP0000534_abnormal_ureter_morphology1.68673308
36MP0006292_abnormal_olfactory_placode1.67962964
37MP0010030_abnormal_orbit_morphology1.67862427
38MP0003635_abnormal_synaptic_transmissio1.66106994
39MP0003941_abnormal_skin_development1.64365341
40MP0005084_abnormal_gallbladder_morpholo1.63841233
41MP0005253_abnormal_eye_physiology1.61524417
42MP0004142_abnormal_muscle_tone1.60071779
43MP0002638_abnormal_pupillary_reflex1.57880653
44MP0003755_abnormal_palate_morphology1.56839959
45MP0000516_abnormal_urinary_system1.56413583
46MP0005367_renal/urinary_system_phenotyp1.56413583
47MP0001486_abnormal_startle_reflex1.54968772
48MP0001970_abnormal_pain_threshold1.52950017
49MP0010386_abnormal_urinary_bladder1.52606804
50MP0002733_abnormal_thermal_nociception1.52119388
51MP0001501_abnormal_sleep_pattern1.50805288
52MP0003935_abnormal_craniofacial_develop1.50580075
53MP0002928_abnormal_bile_duct1.48650138
54MP0005174_abnormal_tail_pigmentation1.47201291
55MP0003942_abnormal_urinary_system1.46381053
56MP0004742_abnormal_vestibular_system1.45260299
57MP0005645_abnormal_hypothalamus_physiol1.45029756
58MP0003880_abnormal_central_pattern1.43957781
59MP0000762_abnormal_tongue_morphology1.43590182
60MP0005257_abnormal_intraocular_pressure1.43217707
61MP0002249_abnormal_larynx_morphology1.42650581
62MP0000427_abnormal_hair_cycle1.41194500
63MP0003045_fibrosis1.40885535
64MP0004145_abnormal_muscle_electrophysio1.40868328
65MP0001188_hyperpigmentation1.40372320
66MP0005167_abnormal_blood-brain_barrier1.39111718
67MP0003937_abnormal_limbs/digits/tail_de1.36868358
68MP0002233_abnormal_nose_morphology1.35817196
69MP0009745_abnormal_behavioral_response1.33987830
70MP0005623_abnormal_meninges_morphology1.33324364
71MP0002116_abnormal_craniofacial_bone1.31525397
72MP0002063_abnormal_learning/memory/cond1.31523300
73MP0002735_abnormal_chemical_nociception1.30579309
74MP0000778_abnormal_nervous_system1.29768019
75MP0004272_abnormal_basement_membrane1.29732394
76MP0005248_abnormal_Harderian_gland1.29676638
77MP0001919_abnormal_reproductive_system1.26942368
78MP0000230_abnormal_systemic_arterial1.26680773
79MP0001502_abnormal_circadian_rhythm1.25981470
80MP0005670_abnormal_white_adipose1.25614592
81MP0005646_abnormal_pituitary_gland1.24127821
82MP0002572_abnormal_emotion/affect_behav1.22365657
83MP0002109_abnormal_limb_morphology1.21602126
84MP0004147_increased_porphyrin_level1.20581646
85MP0001270_distended_abdomen1.16126751
86MP0002064_seizures1.15716912
87MP0000432_abnormal_head_morphology1.14954890
88MP0005389_reproductive_system_phenotype1.13414719
89MP0000163_abnormal_cartilage_morphology1.12339426
90MP0002163_abnormal_gland_morphology1.10412053
91MP0001293_anophthalmia1.10130644
92MP0002108_abnormal_muscle_morphology1.09344219
93MP0000428_abnormal_craniofacial_morphol1.08704956
94MP0003283_abnormal_digestive_organ1.07793474
95MP0002896_abnormal_bone_mineralization1.07597076
96MP0009703_decreased_birth_body1.07373707
97MP0002115_abnormal_skeleton_extremities1.06901316
98MP0002177_abnormal_outer_ear1.06294775
99MP0001968_abnormal_touch/_nociception1.05904597
100MP0001905_abnormal_dopamine_level1.05685892
101MP0005379_endocrine/exocrine_gland_phen1.05438947
102MP0005423_abnormal_somatic_nervous1.05235613
103MP0002557_abnormal_social/conspecific_i1.04504411
104MP0000372_irregular_coat_pigmentation1.04384883
105MP0000026_abnormal_inner_ear1.04223011
106MP0002160_abnormal_reproductive_system1.04202990
107MP0005386_behavior/neurological_phenoty1.04179018
108MP0004924_abnormal_behavior1.04179018
109MP0001346_abnormal_lacrimal_gland1.03068861
110MP0005195_abnormal_posterior_eye1.02968112
111MP0004484_altered_response_of1.02658326
112MP0003137_abnormal_impulse_conducting1.02625473
113MP0002184_abnormal_innervation1.01091521
114MP0003698_abnormal_male_reproductive1.00918930
115MP0002067_abnormal_sensory_capabilities1.00904936
116MP0010368_abnormal_lymphatic_system1.00414233
117MP0002693_abnormal_pancreas_physiology0.99908173
118MP0002932_abnormal_joint_morphology0.99273315
119MP0003938_abnormal_ear_development0.97877640
120MP0002138_abnormal_hepatobiliary_system0.97055832
121MP0003123_paternal_imprinting0.95935425
122MP0002277_abnormal_respiratory_mucosa0.95681504
123MP0003252_abnormal_bile_duct0.95584271
124MP0005448_abnormal_energy_balance0.95396918
125MP0005409_darkened_coat_color0.94455864
126MP0005508_abnormal_skeleton_morphology0.93774842
127MP0008775_abnormal_heart_ventricle0.93267234
128MP0009764_decreased_sensitivity_to0.92959547
129MP0002736_abnormal_nociception_after0.92844717
130MP0001963_abnormal_hearing_physiology0.91694426
131MP0004270_analgesia0.90959361
132MP0008438_abnormal_cutaneous_collagen0.90799893
133MP0008995_early_reproductive_senescence0.90517649
134MP0002272_abnormal_nervous_system0.90482794
135MP0004085_abnormal_heartbeat0.88352231
136MP0000955_abnormal_spinal_cord0.88268465
137MP0002752_abnormal_somatic_nervous0.87401563
138MP0002229_neurodegeneration0.87266652
139MP0001440_abnormal_grooming_behavior0.86983508
140MP0004130_abnormal_muscle_cell0.86018662
141MP0002234_abnormal_pharynx_morphology0.85614741
142MP0002113_abnormal_skeleton_development0.85517238
143MP0008877_abnormal_DNA_methylation0.85504401
144MP0002734_abnormal_mechanical_nocicepti0.84985822
145MP0008961_abnormal_basal_metabolism0.83325566
146MP0004215_abnormal_myocardial_fiber0.83219415
147MP0004858_abnormal_nervous_system0.82658335
148MP0000751_myopathy0.82644915
149MP0002102_abnormal_ear_morphology0.82513965
150MP0005187_abnormal_penis_morphology0.82479426
151MP0006276_abnormal_autonomic_nervous0.82353322
152MP0000631_abnormal_neuroendocrine_gland0.82263358
153MP0001765_abnormal_ion_homeostasis0.81795820
154MP0003115_abnormal_respiratory_system0.81777449
155MP0005083_abnormal_biliary_tract0.81398141
156MP0004134_abnormal_chest_morphology0.81224873
157MP0001929_abnormal_gametogenesis0.80548865
158MP0000733_abnormal_muscle_development0.80462827
159MP0001984_abnormal_olfaction0.80319076
160MP0005085_abnormal_gallbladder_physiolo0.80304275
161MP0002909_abnormal_adrenal_gland0.80136661
162MP0000613_abnormal_salivary_gland0.79761700
163MP0003879_abnormal_hair_cell0.79716373
164MP0001177_atelectasis0.79663653
165MP0009697_abnormal_copulation0.78529537
166MP0003119_abnormal_digestive_system0.77027202
167MP0002114_abnormal_axial_skeleton0.75230654
168MP0000767_abnormal_smooth_muscle0.74490330

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.66548276
2Molar tooth sign on MRI (HP:0002419)4.66548276
3Pancreatic cysts (HP:0001737)4.58819975
4Pancreatic fibrosis (HP:0100732)4.39872274
5Congenital stationary night blindness (HP:0007642)4.28448253
6Type II lissencephaly (HP:0007260)4.18366466
7Nephronophthisis (HP:0000090)3.95091089
8True hermaphroditism (HP:0010459)3.83674984
9Attenuation of retinal blood vessels (HP:0007843)3.66930906
10Abnormality of the renal medulla (HP:0100957)3.39170118
11Cystic liver disease (HP:0006706)3.19615749
12Polydipsia (HP:0001959)3.16091118
13Abnormal drinking behavior (HP:0030082)3.16091118
14Cerebellar dysplasia (HP:0007033)3.15002640
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07168231
16Short 4th metacarpal (HP:0010044)3.07168231
17Febrile seizures (HP:0002373)2.99501224
18Tubular atrophy (HP:0000092)2.96394197
19Cutaneous finger syndactyly (HP:0010554)2.94883087
20Absent eyebrow (HP:0002223)2.91484683
21Midline defect of the nose (HP:0004122)2.88791948
22Abnormality of the renal cortex (HP:0011035)2.84976450
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84837132
24Abnormality of alanine metabolism (HP:0010916)2.84837132
25Hyperalaninemia (HP:0003348)2.84837132
26Progressive cerebellar ataxia (HP:0002073)2.78576437
27Pendular nystagmus (HP:0012043)2.76815290
28Abnormality of the nasal septum (HP:0000419)2.76124184
29Congenital, generalized hypertrichosis (HP:0004540)2.74376349
30Abolished electroretinogram (ERG) (HP:0000550)2.73948979
31Inability to walk (HP:0002540)2.73611163
32Medial flaring of the eyebrow (HP:0010747)2.69338508
33Large for gestational age (HP:0001520)2.66505269
34Shallow orbits (HP:0000586)2.60519059
35Cutaneous syndactyly (HP:0012725)2.53921628
36Focal motor seizures (HP:0011153)2.52829035
37Bell-shaped thorax (HP:0001591)2.51505123
38Sclerocornea (HP:0000647)2.51122276
39Broad metatarsal (HP:0001783)2.51068273
40Polyuria (HP:0000103)2.49757233
41Abnormal rod and cone electroretinograms (HP:0008323)2.48190058
42Congenital sensorineural hearing impairment (HP:0008527)2.46671967
43Bile duct proliferation (HP:0001408)2.46053451
44Abnormal biliary tract physiology (HP:0012439)2.46053451
45Mesomelia (HP:0003027)2.45580061
46Concave nail (HP:0001598)2.44169903
47Genetic anticipation (HP:0003743)2.42331083
48Severe muscular hypotonia (HP:0006829)2.41727928
49Congenital hepatic fibrosis (HP:0002612)2.38867815
50Bony spicule pigmentary retinopathy (HP:0007737)2.37743857
51Progressive inability to walk (HP:0002505)2.35320937
52Patellar aplasia (HP:0006443)2.34738267
53Clumsiness (HP:0002312)2.33036104
54Aplasia/Hypoplasia of the patella (HP:0006498)2.32129458
55Decreased circulating renin level (HP:0003351)2.31973601
56Decreased central vision (HP:0007663)2.31377379
57Lissencephaly (HP:0001339)2.31170056
58Keratoconus (HP:0000563)2.29114369
59Increased corneal curvature (HP:0100692)2.29114369
603-Methylglutaconic aciduria (HP:0003535)2.26766692
61Hepatoblastoma (HP:0002884)2.25759065
62Retinal dysplasia (HP:0007973)2.23414864
63Furrowed tongue (HP:0000221)2.22668508
64Action tremor (HP:0002345)2.20997041
65Abnormality of the parietal bone (HP:0002696)2.20294746
66Rib fusion (HP:0000902)2.19978885
67Narrow palate (HP:0000189)2.19409761
68Hypoplastic ischia (HP:0003175)2.16794620
69Male pseudohermaphroditism (HP:0000037)2.16530744
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15914386
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14705166
72Abnormal respiratory motile cilium morphology (HP:0005938)2.13093197
73Abnormal respiratory epithelium morphology (HP:0012253)2.13093197
74Spinal cord lesions (HP:0100561)2.12138195
75Syringomyelia (HP:0003396)2.12138195
76Morphological abnormality of the middle ear (HP:0008609)2.11183434
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10986459
78Anencephaly (HP:0002323)2.06964722
79White forelock (HP:0002211)2.06606100
80Mesangial abnormality (HP:0001966)2.06436678
81Abnormal urine output (HP:0012590)2.06049792
82Abnormality of the 4th metacarpal (HP:0010012)2.06036527
83Gait imbalance (HP:0002141)2.05998014
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.05283814
85Asymmetry of the thorax (HP:0001555)2.05241078
86Limited hip movement (HP:0008800)2.04747366
87Tachypnea (HP:0002789)2.04465911
88Abnormality of the right ventricle (HP:0001707)2.03675191
89Follicular hyperkeratosis (HP:0007502)2.03482937
90Turricephaly (HP:0000262)2.00638255
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00242900
92Congenital primary aphakia (HP:0007707)1.98610089
93Epileptic encephalopathy (HP:0200134)1.98548542
94Myelomeningocele (HP:0002475)1.96440326
95Supernumerary ribs (HP:0005815)1.93866024
96Lip pit (HP:0100267)1.92297475
97Trigonocephaly (HP:0000243)1.91661115
98Chorioretinal atrophy (HP:0000533)1.91075122
99Urethral obstruction (HP:0000796)1.90562304
100Hypoplasia of the maxilla (HP:0000327)1.90511834
101Coronal craniosynostosis (HP:0004440)1.90225933
102Nephrogenic diabetes insipidus (HP:0009806)1.89576107
103Patchy hypopigmentation of hair (HP:0011365)1.89147749
104Hypoplasia of the pons (HP:0012110)1.89071078
105Broad-based gait (HP:0002136)1.88694420
106Microglossia (HP:0000171)1.88523523
107Focal seizures (HP:0007359)1.87961993
108Abnormality of the ischium (HP:0003174)1.87592376
109Anterior segment dysgenesis (HP:0007700)1.87335845
110Postaxial foot polydactyly (HP:0001830)1.86580019
111Ketoacidosis (HP:0001993)1.86128079
112Abnormality of the pons (HP:0007361)1.85755283
113Increased number of teeth (HP:0011069)1.85448321
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.85122211
115Optic disc pallor (HP:0000543)1.84986557
116Optic nerve hypoplasia (HP:0000609)1.84384928
117Narrow nasal bridge (HP:0000446)1.83195956
118Atrial fibrillation (HP:0005110)1.82458946
119Renal duplication (HP:0000075)1.82414415
120Hemiparesis (HP:0001269)1.82408549
121Mitochondrial inheritance (HP:0001427)1.82372229
122Abnormality of renal excretion (HP:0011036)1.79915175
123Absent frontal sinuses (HP:0002688)1.79175211
124Renal hypoplasia (HP:0000089)1.78903056
125Ketosis (HP:0001946)1.78704880
126Macroorchidism (HP:0000053)1.78079108
127Smooth philtrum (HP:0000319)1.77894014
128Hyperventilation (HP:0002883)1.77356968
129Aplasia involving bones of the extremities (HP:0009825)1.76697126
130Aplasia involving bones of the upper limbs (HP:0009823)1.76697126
131Aplasia of the phalanges of the hand (HP:0009802)1.76697126
132Thyroid-stimulating hormone excess (HP:0002925)1.75932585
133Protruding tongue (HP:0010808)1.75292325
134Omphalocele (HP:0001539)1.74498147
135Severe visual impairment (HP:0001141)1.74060263
136Agitation (HP:0000713)1.73871337
137Broad thumb (HP:0011304)1.73289479
138Pachygyria (HP:0001302)1.72664506
139Bulbous nose (HP:0000414)1.72637442
140Mixed hearing impairment (HP:0000410)1.72113496
141Hypoplastic labia majora (HP:0000059)1.72087492
142Tracheomalacia (HP:0002779)1.71644113
143Bilateral microphthalmos (HP:0007633)1.71446668
144Birth length less than 3rd percentile (HP:0003561)1.71423345
145Occipital encephalocele (HP:0002085)1.71117680
146Long eyelashes (HP:0000527)1.70789342
147Aqueductal stenosis (HP:0002410)1.68559515
148Prolonged QT interval (HP:0001657)1.68005750
149Absent thumb (HP:0009777)1.67649109
150Increased CSF lactate (HP:0002490)1.67541517
151Abnormality of incisor morphology (HP:0011063)1.66498913
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.66277311
153Progressive microcephaly (HP:0000253)1.65211144
154Primary atrial arrhythmia (HP:0001692)1.65016041
155Broad finger (HP:0001500)1.64279462
156Excessive salivation (HP:0003781)1.63362466
157Drooling (HP:0002307)1.63362466
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63115323
159Supernumerary bones of the axial skeleton (HP:0009144)1.62831182
160Abnormality of the pubic bones (HP:0003172)1.62680174
161Atrophic scars (HP:0001075)1.62569352
162Acute necrotizing encephalopathy (HP:0006965)1.62038947
163Broad phalanx (HP:0006009)1.61566992
164Chronic hepatic failure (HP:0100626)1.59802670
165Bradycardia (HP:0001662)1.59713024
166Anal stenosis (HP:0002025)1.59285599
167Broad toe (HP:0001837)1.58761388
168Broad long bones (HP:0005622)1.58746441
169Dental malocclusion (HP:0000689)1.58407842
170Labial hypoplasia (HP:0000066)1.57608913
171Abnormality of the calf musculature (HP:0001430)1.56429292
172Broad phalanges of the hand (HP:0009768)1.56353261
173Hypoventilation (HP:0002791)1.55676372
174Obsessive-compulsive behavior (HP:0000722)1.55566550
175Tubulointerstitial nephritis (HP:0001970)1.54920085
176Gaze-evoked nystagmus (HP:0000640)1.54737472
177Abnormality of the nasolacrimal system (HP:0000614)1.54080005
178Submucous cleft hard palate (HP:0000176)1.53694765
179Absent/shortened dynein arms (HP:0200106)1.53685412
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.53685412
181Long nose (HP:0003189)1.53199753
182Broad ribs (HP:0000885)1.52316016
183Abnormality of the phalanges of the hallux (HP:0010057)1.51888881
184Anophthalmia (HP:0000528)1.51751955
185Renal dysplasia (HP:0000110)1.51669505
186Absent speech (HP:0001344)1.51512410
187Abnormality of the labia majora (HP:0012881)1.51301700
188Preaxial foot polydactyly (HP:0001841)1.51036417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.96383422
2TLK13.62566437
3INSRR3.41649722
4WNK42.85268818
5NTRK32.83760387
6GRK12.76438946
7LATS12.63204374
8MAP4K22.61601292
9CAMK1G2.52935541
10CAMK1D2.52003957
11BRD42.47299115
12EPHA42.46652144
13TAOK32.43739161
14CASK2.33743080
15SIK12.33551958
16SIK32.32425893
17ACVR1B2.25412567
18PINK12.16513386
19DDR22.13759137
20AKT31.97473030
21CDK121.86206673
22SIK21.83139097
23TNIK1.81449855
24MAPK151.77337982
25WNK11.68604104
26ZAK1.66863611
27RIPK41.62231826
28NUAK11.61861266
29DMPK1.59954718
30SGK21.53157739
31TXK1.50375547
32ERBB31.49829956
33MKNK21.43464019
34MAP3K41.42494209
35ADRBK11.39710946
36OXSR11.38208011
37MAP2K71.35917805
38TAOK21.34702783
39PLK21.30591530
40BCKDK1.29636691
41PNCK1.29226194
42SGK31.27941967
43YES11.24601467
44CDC42BPA1.21194636
45EPHA31.20259655
46STK381.19486405
47TGFBR11.18296445
48NEK61.10653195
49MAPKAPK31.10434715
50NEK21.05883738
51MAPK131.05350552
52FGFR21.04894106
53PLK41.02837286
54SGK4941.02436097
55SGK2231.02436097
56WNK31.01765721
57SGK11.00154313
58RIPK10.99422435
59CAMK10.96811187
60CDK30.95764277
61STK390.95033034
62PDGFRA0.93627725
63MUSK0.93307207
64PIK3CA0.92268985
65EPHB20.92008375
66FER0.90664449
67DAPK20.89699727
68FGFR10.88852734
69EIF2AK20.87605802
70MARK20.86868618
71DYRK20.86331541
72MAP2K60.86314056
73IKBKB0.85811591
74PRKD30.85623903
75FRK0.85134994
76PRKCH0.84821351
77PRKCE0.84505984
78MAP3K130.82441754
79PRPF4B0.82144943
80CHUK0.82120024
81STK38L0.82053819
82OBSCN0.80388554
83PRKAA20.79343119
84PDGFRB0.78435019
85TGFBR20.77608014
86PTK2B0.77406806
87NTRK20.75973213
88CAMK40.74697105
89MKNK10.73648391
90RPS6KA60.71085972
91MAP3K140.70085414
92MARK30.67748205
93CDK190.66645486
94ERBB20.66164484
95STK110.63909530
96DYRK1A0.63280882
97PRKG10.61629723
98KIT0.61035144
99TNK20.60766158
100RPS6KA50.60467553
101STK30.60215299
102IRAK10.58633881
103PHKG10.58555657
104PHKG20.58555657
105MAP3K110.58402152
106PAK30.57941733
107PTK20.57606518
108MAP2K20.57013950
109LATS20.56837790
110CAMKK20.56821447
111MARK10.56295788
112LIMK10.54859734
113PKN10.54705237
114MINK10.54562641
115GRK70.53495349
116MAP2K40.53315035
117CSNK1A1L0.50590416
118PRKCG0.50342145
119PRKCQ0.50037305
120JAK10.49142939
121GSK3B0.48128841
122MAPK80.47877642
123CAMK2A0.47823029
124CDK50.47329484
125MAPK100.47166658
126PAK60.46287337
127CDK80.46188413
128PRKACA0.46107634
129TTN0.45561132
130MAP3K70.44240376
131ROCK10.42190466
132FGFR30.42020012
133MAPKAPK50.41744752
134RPS6KA30.41729900
135TRPM70.41706950
136MAPK70.41555629
137PRKCZ0.41294669
138BMPR1B0.40149764
139PRKCI0.39924527
140PRKAA10.39488750
141IGF1R0.38973340
142IRAK40.38627306
143CAMKK10.37724484
144CSNK1G30.37401487
145CSNK1G20.35897523
146TIE10.35573671
147SRC0.35505242
148CSNK1A10.34989249
149PRKCA0.34611117
150GRK50.32499297
151SYK0.32046375
152MAP2K10.31306698
153IKBKE0.30173613
154MAPK110.28946708

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06725297
2Linoleic acid metabolism_Homo sapiens_hsa005913.02690036
3Phototransduction_Homo sapiens_hsa047442.80671795
4Nicotine addiction_Homo sapiens_hsa050332.75233422
5Nitrogen metabolism_Homo sapiens_hsa009102.49471007
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32812205
7Oxidative phosphorylation_Homo sapiens_hsa001902.18035652
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12785192
9Caffeine metabolism_Homo sapiens_hsa002322.10991522
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09355135
11Circadian entrainment_Homo sapiens_hsa047132.02212560
12Selenocompound metabolism_Homo sapiens_hsa004502.01427838
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.01370941
14Ether lipid metabolism_Homo sapiens_hsa005652.01171318
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99514838
16Butanoate metabolism_Homo sapiens_hsa006501.92200019
17Glutamatergic synapse_Homo sapiens_hsa047241.88437648
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83603828
19Insulin secretion_Homo sapiens_hsa049111.73123126
20Dilated cardiomyopathy_Homo sapiens_hsa054141.71804381
21Type II diabetes mellitus_Homo sapiens_hsa049301.70136732
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.69871979
23Morphine addiction_Homo sapiens_hsa050321.69134203
24Tryptophan metabolism_Homo sapiens_hsa003801.66619688
25Long-term potentiation_Homo sapiens_hsa047201.66385993
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65287580
27Amphetamine addiction_Homo sapiens_hsa050311.63810399
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62950663
29GABAergic synapse_Homo sapiens_hsa047271.60366885
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60187429
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56714291
32Axon guidance_Homo sapiens_hsa043601.54344174
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53037031
34Taste transduction_Homo sapiens_hsa047421.51274573
35Parkinsons disease_Homo sapiens_hsa050121.51125289
36Calcium signaling pathway_Homo sapiens_hsa040201.47937042
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46469137
38Cardiac muscle contraction_Homo sapiens_hsa042601.45224142
39Renin secretion_Homo sapiens_hsa049241.43091016
40Arachidonic acid metabolism_Homo sapiens_hsa005901.40246729
41Cocaine addiction_Homo sapiens_hsa050301.40244561
42Sulfur relay system_Homo sapiens_hsa041221.39028741
43Olfactory transduction_Homo sapiens_hsa047401.38854764
44RNA polymerase_Homo sapiens_hsa030201.37973615
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37325031
46cAMP signaling pathway_Homo sapiens_hsa040241.36813510
47Salivary secretion_Homo sapiens_hsa049701.36492853
48Fanconi anemia pathway_Homo sapiens_hsa034601.34580271
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33085542
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30617490
51Adherens junction_Homo sapiens_hsa045201.28638942
52Basal cell carcinoma_Homo sapiens_hsa052171.28158635
53Synaptic vesicle cycle_Homo sapiens_hsa047211.27626315
54ABC transporters_Homo sapiens_hsa020101.24107593
55Homologous recombination_Homo sapiens_hsa034401.23734164
56Cholinergic synapse_Homo sapiens_hsa047251.23206580
57Dopaminergic synapse_Homo sapiens_hsa047281.22124463
58Long-term depression_Homo sapiens_hsa047301.21871806
59Oxytocin signaling pathway_Homo sapiens_hsa049211.18619599
60Basal transcription factors_Homo sapiens_hsa030221.16906105
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16567464
62Wnt signaling pathway_Homo sapiens_hsa043101.15831488
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14870162
64Hedgehog signaling pathway_Homo sapiens_hsa043401.13737855
65ECM-receptor interaction_Homo sapiens_hsa045121.13538254
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12967173
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.09521783
68Asthma_Homo sapiens_hsa053101.08919161
69Chemical carcinogenesis_Homo sapiens_hsa052041.06466364
70Huntingtons disease_Homo sapiens_hsa050161.05341433
71Alzheimers disease_Homo sapiens_hsa050101.05333142
72Gastric acid secretion_Homo sapiens_hsa049711.04447135
73Melanogenesis_Homo sapiens_hsa049161.04236013
74GnRH signaling pathway_Homo sapiens_hsa049121.03547543
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02882816
76Serotonergic synapse_Homo sapiens_hsa047261.02398255
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.96415556
78Ovarian steroidogenesis_Homo sapiens_hsa049130.96284969
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96097937
80Regulation of autophagy_Homo sapiens_hsa041400.94918253
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.93566198
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92714880
83Focal adhesion_Homo sapiens_hsa045100.92068920
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92057098
85Peroxisome_Homo sapiens_hsa041460.90972038
86Rap1 signaling pathway_Homo sapiens_hsa040150.89663899
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88977828
88Proteoglycans in cancer_Homo sapiens_hsa052050.86885776
89Hippo signaling pathway_Homo sapiens_hsa043900.86731162
90Circadian rhythm_Homo sapiens_hsa047100.85917302
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85067616
92Protein digestion and absorption_Homo sapiens_hsa049740.84028934
93Lysine degradation_Homo sapiens_hsa003100.83856256
94Dorso-ventral axis formation_Homo sapiens_hsa043200.82954039
95Gap junction_Homo sapiens_hsa045400.82513395
96Melanoma_Homo sapiens_hsa052180.82277378
97Protein export_Homo sapiens_hsa030600.82277193
98MAPK signaling pathway_Homo sapiens_hsa040100.82098921
99ErbB signaling pathway_Homo sapiens_hsa040120.80312545
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76944571
101MicroRNAs in cancer_Homo sapiens_hsa052060.76297684
102Pancreatic secretion_Homo sapiens_hsa049720.75028041
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74626869
104Glioma_Homo sapiens_hsa052140.74058145
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73805422
106Estrogen signaling pathway_Homo sapiens_hsa049150.73722600
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72645769
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72616091
109Glycerolipid metabolism_Homo sapiens_hsa005610.71608181
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71346826
111Fatty acid biosynthesis_Homo sapiens_hsa000610.71219312
112Graft-versus-host disease_Homo sapiens_hsa053320.70676895
113RNA degradation_Homo sapiens_hsa030180.70174369
114Mineral absorption_Homo sapiens_hsa049780.70054464
115Prostate cancer_Homo sapiens_hsa052150.69744676
116Retinol metabolism_Homo sapiens_hsa008300.69311507
117Allograft rejection_Homo sapiens_hsa053300.68660210
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68575883
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68473997
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67696631
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.66806091
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66034181
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65987873
124Ras signaling pathway_Homo sapiens_hsa040140.65285615
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63347875
126African trypanosomiasis_Homo sapiens_hsa051430.63243547
127Renin-angiotensin system_Homo sapiens_hsa046140.61902921
128Autoimmune thyroid disease_Homo sapiens_hsa053200.61552997
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60879746
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60726169
131Thyroid hormone synthesis_Homo sapiens_hsa049180.59395953
132TNF signaling pathway_Homo sapiens_hsa046680.58706334
133Tight junction_Homo sapiens_hsa045300.58456037
134Propanoate metabolism_Homo sapiens_hsa006400.58283861
135TGF-beta signaling pathway_Homo sapiens_hsa043500.58138844
136Inositol phosphate metabolism_Homo sapiens_hsa005620.57453860
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57430235
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57062318
139Glucagon signaling pathway_Homo sapiens_hsa049220.56245150
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55833475
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55557250
142Endometrial cancer_Homo sapiens_hsa052130.55357766
143Choline metabolism in cancer_Homo sapiens_hsa052310.55046153
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.55043444
145Amoebiasis_Homo sapiens_hsa051460.54478276
146Type I diabetes mellitus_Homo sapiens_hsa049400.54323587
147Collecting duct acid secretion_Homo sapiens_hsa049660.53979760
148Rheumatoid arthritis_Homo sapiens_hsa053230.52792574
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52660716
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51593335
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.51502375
152Pathways in cancer_Homo sapiens_hsa052000.50804321
153Histidine metabolism_Homo sapiens_hsa003400.49720466
154Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49019883
155beta-Alanine metabolism_Homo sapiens_hsa004100.46312440
156Metabolic pathways_Homo sapiens_hsa011000.45972508
157Sulfur metabolism_Homo sapiens_hsa009200.43045750
158Fat digestion and absorption_Homo sapiens_hsa049750.42226979
159Purine metabolism_Homo sapiens_hsa002300.40215405
160NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38252800
161SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34717320
162Vitamin digestion and absorption_Homo sapiens_hsa049770.33270011
163Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30927278

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