SPACA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.98340893
2spermatid development (GO:0007286)9.38921622
3cilium movement (GO:0003341)8.85826275
4motile cilium assembly (GO:0044458)8.74839499
5regulation of cilium movement (GO:0003352)8.03345416
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.87189548
7single fertilization (GO:0007338)7.83575322
8sperm capacitation (GO:0048240)7.74660170
9male meiosis (GO:0007140)7.30807146
10piRNA metabolic process (GO:0034587)6.98109170
11synaptonemal complex organization (GO:0070193)6.90082490
12synaptonemal complex assembly (GO:0007130)6.88303857
13fertilization (GO:0009566)6.46183803
14spermatogenesis (GO:0007283)6.19710973
15male gamete generation (GO:0048232)6.17472471
16microtubule depolymerization (GO:0007019)5.93878352
17negative regulation of inclusion body assembly (GO:0090084)5.84595054
18organic cation transport (GO:0015695)5.78874760
19gamete generation (GO:0007276)5.67781663
20spermatid nucleus differentiation (GO:0007289)5.63107467
21ventricular system development (GO:0021591)5.57735413
22cell recognition (GO:0008037)5.39126906
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.29887700
24calcium ion-dependent exocytosis (GO:0017156)5.25904656
25germ cell development (GO:0007281)5.19714287
26regulation of inclusion body assembly (GO:0090083)5.15095049
27microtubule severing (GO:0051013)5.10493769
28chromosome organization involved in meiosis (GO:0070192)4.82050835
29male meiosis I (GO:0007141)4.74036024
30regulation of microtubule-based movement (GO:0060632)4.68057195
31glycerol ether metabolic process (GO:0006662)4.51340872
32DNA methylation involved in gamete generation (GO:0043046)4.51249828
33L-fucose catabolic process (GO:0042355)4.49256689
34fucose catabolic process (GO:0019317)4.49256689
35L-fucose metabolic process (GO:0042354)4.49256689
36multicellular organismal reproductive process (GO:0048609)4.47014440
37seminiferous tubule development (GO:0072520)4.42685144
38protein K11-linked deubiquitination (GO:0035871)4.30456146
39sexual reproduction (GO:0019953)4.17870282
40ether metabolic process (GO:0018904)4.16238293
41meiotic nuclear division (GO:0007126)4.14151277
42DNA deamination (GO:0045006)4.09327430
43left/right pattern formation (GO:0060972)4.08826477
44behavioral response to nicotine (GO:0035095)4.07208633
45indolalkylamine metabolic process (GO:0006586)4.03326824
46genitalia morphogenesis (GO:0035112)3.98259948
47single strand break repair (GO:0000012)3.87289224
48water-soluble vitamin biosynthetic process (GO:0042364)3.81558342
49respiratory chain complex IV assembly (GO:0008535)3.78958152
50chromosome condensation (GO:0030261)3.76268981
51meiosis I (GO:0007127)3.69130154
52multicellular organismal development (GO:0007275)3.66386553
53monoubiquitinated protein deubiquitination (GO:0035520)3.61294738
54response to pheromone (GO:0019236)3.58426862
55protein polyglutamylation (GO:0018095)3.56609450
56DNA packaging (GO:0006323)3.51646022
57platelet dense granule organization (GO:0060155)3.47366703
58protein complex biogenesis (GO:0070271)3.42334210
59cellular ketone body metabolic process (GO:0046950)3.42087875
60detection of light stimulus involved in visual perception (GO:0050908)3.40642748
61detection of light stimulus involved in sensory perception (GO:0050962)3.40642748
62dopamine transport (GO:0015872)3.40100305
63chaperone-mediated protein complex assembly (GO:0051131)3.37739501
64tryptophan metabolic process (GO:0006568)3.35642473
65cytochrome complex assembly (GO:0017004)3.34576554
66DNA double-strand break processing (GO:0000729)3.32194765
67indole-containing compound catabolic process (GO:0042436)3.30406449
68indolalkylamine catabolic process (GO:0046218)3.30406449
69tryptophan catabolic process (GO:0006569)3.30406449
70mannosylation (GO:0097502)3.28836877
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27250847
72sequestering of actin monomers (GO:0042989)3.26929953
73protein-cofactor linkage (GO:0018065)3.21328449
74mitochondrial respiratory chain complex I assembly (GO:0032981)3.17422006
75NADH dehydrogenase complex assembly (GO:0010257)3.17422006
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17422006
77glycerophospholipid catabolic process (GO:0046475)3.16257022
78microtubule polymerization or depolymerization (GO:0031109)3.13965746
79meiotic cell cycle (GO:0051321)3.09934099
80regulation of action potential (GO:0098900)3.09669427
81alditol metabolic process (GO:0019400)3.07820350
82GTP biosynthetic process (GO:0006183)3.06277849
83nucleoside diphosphate phosphorylation (GO:0006165)3.05574467
84ketone body metabolic process (GO:1902224)3.05503065
85mitochondrial respiratory chain complex assembly (GO:0033108)3.03978527
86indole-containing compound metabolic process (GO:0042430)3.03062835
87synapsis (GO:0007129)3.00982573
88microtubule-based movement (GO:0007018)3.00073702
89protein localization to cilium (GO:0061512)2.99857246
90negative regulation of telomere maintenance (GO:0032205)2.99687520
91primary amino compound metabolic process (GO:1901160)2.99274572
92kynurenine metabolic process (GO:0070189)2.95473751
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95343630
94cilium organization (GO:0044782)2.92440157
95replication fork processing (GO:0031297)2.91110025
96regulation of spindle checkpoint (GO:0090231)2.86532315
97cellular component assembly involved in morphogenesis (GO:0010927)2.85615495
98intraciliary transport (GO:0042073)2.84996988
99cornea development in camera-type eye (GO:0061303)2.82224025
100polyol catabolic process (GO:0046174)2.82084963
101protein refolding (GO:0042026)2.81397735
102cilium assembly (GO:0042384)2.81268882
103proteasome assembly (GO:0043248)2.81146977
104interferon-gamma secretion (GO:0072643)2.80535846
105preassembly of GPI anchor in ER membrane (GO:0016254)2.79933534
106protein K6-linked ubiquitination (GO:0085020)2.79497679
107centriole assembly (GO:0098534)2.78659253
108glycolytic process (GO:0006096)2.77702886
109glycerol metabolic process (GO:0006071)2.76046601
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75439965
111axoneme assembly (GO:0035082)2.74883838
112neuronal action potential (GO:0019228)2.74872966
113pseudouridine synthesis (GO:0001522)2.73887151
114UTP biosynthetic process (GO:0006228)2.71366262
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.71231797
116serotonin metabolic process (GO:0042428)2.70680873
117lactate metabolic process (GO:0006089)2.70029580
118positive regulation of macrophage activation (GO:0043032)2.69976372
119negative regulation of mast cell activation (GO:0033004)2.69304185
120peristalsis (GO:0030432)2.68826042
121regulation of neurotransmitter uptake (GO:0051580)2.68731322
122meiotic cell cycle process (GO:1903046)2.67971758
123carnitine transport (GO:0015879)2.67803275
124amino-acid betaine transport (GO:0015838)2.67803275
125cilium morphogenesis (GO:0060271)2.67568892
126nucleus organization (GO:0006997)2.64702841
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64064691
128UTP metabolic process (GO:0046051)2.61462184
129adaptation of signaling pathway (GO:0023058)2.61052792
130negative regulation of organelle assembly (GO:1902116)2.61029938
131tachykinin receptor signaling pathway (GO:0007217)2.60406878
132regulation of hexokinase activity (GO:1903299)2.60035352
133regulation of glucokinase activity (GO:0033131)2.60035352
134centriole replication (GO:0007099)2.59981737
135regulation of centriole replication (GO:0046599)2.59703654
136C4-dicarboxylate transport (GO:0015740)2.59213733
137anterograde synaptic vesicle transport (GO:0048490)2.58480061
138kidney morphogenesis (GO:0060993)2.57683819
139carnitine transmembrane transport (GO:1902603)2.54562532
140inositol phosphate catabolic process (GO:0071545)2.52627321
1413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52068408
142purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52068408
143regulation of telomere maintenance (GO:0032204)2.52010024
144retinal cone cell development (GO:0046549)2.50475442
145photoreceptor cell maintenance (GO:0045494)2.48910680
146auditory receptor cell stereocilium organization (GO:0060088)2.47729315
147photoreceptor cell development (GO:0042461)2.47620400
148phasic smooth muscle contraction (GO:0014821)2.46863203
149neuronal action potential propagation (GO:0019227)2.46361176
150calcium ion import (GO:0070509)2.44597073
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43843693
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43843693
153transmission of nerve impulse (GO:0019226)2.43485146
154recombinational repair (GO:0000725)2.42911903
155double-strand break repair via homologous recombination (GO:0000724)2.42619791
156startle response (GO:0001964)2.41852770
157rhodopsin mediated signaling pathway (GO:0016056)2.41644780
158mitotic sister chromatid cohesion (GO:0007064)2.41385221
159fucosylation (GO:0036065)2.40025150
160peptidyl-glutamic acid modification (GO:0018200)2.38694088
161protein import into peroxisome matrix (GO:0016558)2.38640994
162S-adenosylmethionine metabolic process (GO:0046500)2.38250210
163reciprocal DNA recombination (GO:0035825)2.37373937
164reciprocal meiotic recombination (GO:0007131)2.37373937
165reflex (GO:0060004)2.36195417
166tRNA processing (GO:0008033)2.35778458
167peptidyl-histidine modification (GO:0018202)2.35736905
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.33755411
169regulation of translation, ncRNA-mediated (GO:0045974)2.33755411
170negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.33755411
171negative regulation of skeletal muscle tissue development (GO:0048642)2.33643518
172negative regulation of heart rate (GO:0010459)2.33477170
173fusion of sperm to egg plasma membrane (GO:0007342)14.4376664
174cell wall macromolecule catabolic process (GO:0016998)13.9135380
175cell wall macromolecule metabolic process (GO:0044036)13.9135380
176sperm motility (GO:0030317)13.6723923
177acrosome assembly (GO:0001675)12.8813823
178multicellular organism reproduction (GO:0032504)12.0023709
179sperm-egg recognition (GO:0035036)11.8628699
180acrosome reaction (GO:0007340)11.2352009
181plasma membrane fusion (GO:0045026)10.9718902
182cell-cell recognition (GO:0009988)10.7687709
183cilium or flagellum-dependent cell motility (GO:0001539)10.7254714
184binding of sperm to zona pellucida (GO:0007339)10.6146571
185epithelial cilium movement (GO:0003351)10.4748446
186reproduction (GO:0000003)10.2637780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.21828564
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.87852659
3EZH2_22144423_ChIP-Seq_EOC_Human3.91777176
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34855650
5GBX2_23144817_ChIP-Seq_PC3_Human2.99767669
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81900946
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80845898
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.56045911
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53863359
10VDR_22108803_ChIP-Seq_LS180_Human2.48018771
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41481269
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30866266
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26101870
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20347490
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.10139788
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05144678
17IGF1R_20145208_ChIP-Seq_DFB_Human2.04197972
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01032605
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00629539
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.97950331
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.97166409
22P300_19829295_ChIP-Seq_ESCs_Human1.97062447
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96279220
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95987919
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95001142
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91800630
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89421363
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.85656853
29FUS_26573619_Chip-Seq_HEK293_Human1.80705633
30ZNF274_21170338_ChIP-Seq_K562_Hela1.79514949
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78369840
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.78244504
33STAT1_17558387_ChIP-Seq_HELA_Human1.76257917
34BCAT_22108803_ChIP-Seq_LS180_Human1.72642532
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72296818
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.72281502
37EWS_26573619_Chip-Seq_HEK293_Human1.71285488
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71157488
39KDM2B_26808549_Chip-Seq_REH_Human1.70339043
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66493556
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66079493
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64782288
43TP53_22573176_ChIP-Seq_HFKS_Human1.63875448
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63077065
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.61232582
46AR_25329375_ChIP-Seq_VCAP_Human1.57884064
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57315619
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.57106802
49MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56417457
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.53790953
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53790953
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.53111421
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52502931
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.50846206
55CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49184948
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46613512
57CBP_20019798_ChIP-Seq_JUKART_Human1.46472600
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46472600
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46212689
60SMAD4_21799915_ChIP-Seq_A2780_Human1.45521935
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44953970
62STAT3_23295773_ChIP-Seq_U87_Human1.44489338
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43794525
64P53_22387025_ChIP-Seq_ESCs_Mouse1.43645273
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43221301
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.42808592
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.42778217
68TCF4_23295773_ChIP-Seq_U87_Human1.41797996
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.41465611
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.40690320
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.40221369
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40195351
73FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39802953
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39637990
75RNF2_27304074_Chip-Seq_NSC_Mouse1.39520244
76P300_18555785_Chip-Seq_ESCs_Mouse1.36817747
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.36292395
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34707525
79AR_20517297_ChIP-Seq_VCAP_Human1.34185269
80SOX2_19829295_ChIP-Seq_ESCs_Human1.33888405
81NANOG_19829295_ChIP-Seq_ESCs_Human1.33888405
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.31354023
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31268821
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.31075350
85TCF4_22108803_ChIP-Seq_LS180_Human1.31044976
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30961798
87MYC_18940864_ChIP-ChIP_HL60_Human1.30224017
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30154416
89TAF15_26573619_Chip-Seq_HEK293_Human1.29995477
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29844961
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29011076
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28175095
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.27793748
94REST_21632747_ChIP-Seq_MESCs_Mouse1.27577714
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.27259162
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26998718
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26785664
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26235287
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.25911164
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24729423
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23268852
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.21526906
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.21162768
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20466239
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.20383086
106AR_21572438_ChIP-Seq_LNCaP_Human1.20279426
107GATA3_21867929_ChIP-Seq_TH1_Mouse1.19746042
108VDR_23849224_ChIP-Seq_CD4+_Human1.19632415
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.19487108
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18955507
111RUNX2_22187159_ChIP-Seq_PCA_Human1.18497502
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18057807
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17557699
114PU1_27457419_Chip-Seq_LIVER_Mouse1.16489059
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16066493
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.15821621
117NCOR_22424771_ChIP-Seq_293T_Human1.15413590
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15171106
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15171106
120P53_21459846_ChIP-Seq_SAOS-2_Human1.15099451
121GF1_26923725_Chip-Seq_HPCs_Mouse1.14915801
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14472711
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.14163305
124HOXB7_26014856_ChIP-Seq_BT474_Human1.13350871
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13208686
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13150742
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12899978
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.12221692
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.11436200
130ELK1_19687146_ChIP-ChIP_HELA_Human1.09135055
131IRF1_19129219_ChIP-ChIP_H3396_Human1.08970362
132RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08516781
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.08242088
134SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06720929
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06218162
136CDX2_22108803_ChIP-Seq_LS180_Human1.06079263
137SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05825080
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.05694520
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05669938
140ZFX_18555785_Chip-Seq_ESCs_Mouse1.05561118
141RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04713739
142HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04612118
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.02582636
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01429917
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00855507
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98535451
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.97025290
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96813728
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.95152888
150* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93816607
151NFYB_21822215_ChIP-Seq_K562_Human0.93082016
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92787507
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90190596
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89966926
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89142990
156ER_23166858_ChIP-Seq_MCF-7_Human0.88890295
157SOX9_26525672_Chip-Seq_HEART_Mouse0.88303512
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.87424800
159TBL1_22424771_ChIP-Seq_293T_Human0.87149606
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87122273
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86781297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08595862
2MP0001929_abnormal_gametogenesis5.47987794
3MP0008877_abnormal_DNA_methylation4.19568707
4MP0002210_abnormal_sex_determination3.42546750
5MP0002161_abnormal_fertility/fecundity3.25600065
6MP0000569_abnormal_digit_pigmentation2.90857519
7MP0003880_abnormal_central_pattern2.90021138
8MP0001145_abnormal_male_reproductive2.88739871
9MP0003787_abnormal_imprinting2.61695036
10MP0000653_abnormal_sex_gland2.52268720
11MP0005623_abnormal_meninges_morphology2.49224335
12MP0003195_calcinosis2.48236658
13MP0002653_abnormal_ependyma_morphology2.32870483
14MP0002837_dystrophic_cardiac_calcinosis2.30093023
15MP0004147_increased_porphyrin_level2.15416990
16MP0001501_abnormal_sleep_pattern2.05337368
17MP0005670_abnormal_white_adipose2.04457687
18MP0008872_abnormal_physiological_respon2.03306324
19MP0005646_abnormal_pituitary_gland2.00721653
20MP0008875_abnormal_xenobiotic_pharmacok2.00505773
21MP0005410_abnormal_fertilization16.0724338
22MP0009745_abnormal_behavioral_response1.85644856
23MP0000372_irregular_coat_pigmentation1.55580335
24MP0010386_abnormal_urinary_bladder1.51761657
25MP0002138_abnormal_hepatobiliary_system1.51437757
26MP0006292_abnormal_olfactory_placode1.47329068
27MP0004043_abnormal_pH_regulation1.45030701
28MP0002282_abnormal_trachea_morphology1.43421211
29MP0006276_abnormal_autonomic_nervous1.40806288
30MP0001486_abnormal_startle_reflex1.39580369
31MP0000631_abnormal_neuroendocrine_gland1.39375043
32MP0002938_white_spotting1.38943984
33MP0009046_muscle_twitch1.37034544
34MP0002160_abnormal_reproductive_system1.36956996
35MP0005379_endocrine/exocrine_gland_phen1.36832159
36MP0001765_abnormal_ion_homeostasis1.36169651
37MP0004142_abnormal_muscle_tone1.35918445
38MP0002909_abnormal_adrenal_gland1.31280700
39MP0003121_genomic_imprinting1.31217690
40MP0002557_abnormal_social/conspecific_i1.28845853
41MP0002572_abnormal_emotion/affect_behav1.28303157
42MP0003718_maternal_effect1.27740008
43MP0005645_abnormal_hypothalamus_physiol1.27236590
44MP0005174_abnormal_tail_pigmentation1.26592882
45MP0002163_abnormal_gland_morphology1.25418676
46MP0005084_abnormal_gallbladder_morpholo1.23267711
47MP0001485_abnormal_pinna_reflex1.22284219
48MP0009780_abnormal_chondrocyte_physiolo1.21246204
49MP0001970_abnormal_pain_threshold1.19575351
50MP0002064_seizures1.17301242
51MP0004885_abnormal_endolymph1.13976283
52MP0005647_abnormal_sex_gland1.13299101
53MP0002733_abnormal_thermal_nociception1.11315554
54MP0002102_abnormal_ear_morphology1.08476892
55MP0002735_abnormal_chemical_nociception1.08325746
56MP0003122_maternal_imprinting1.07945388
57MP0004924_abnormal_behavior1.06114839
58MP0005386_behavior/neurological_phenoty1.06114839
59MP0004145_abnormal_muscle_electrophysio1.05287853
60MP0003011_delayed_dark_adaptation1.03871872
61MP0002693_abnormal_pancreas_physiology1.02314546
62MP0001905_abnormal_dopamine_level0.99727681
63MP0005365_abnormal_bile_salt0.98436106
64MP0009697_abnormal_copulation0.98084104
65MP0002234_abnormal_pharynx_morphology0.98003024
66MP0005167_abnormal_blood-brain_barrier0.96720337
67MP0004233_abnormal_muscle_weight0.96209723
68MP0005332_abnormal_amino_acid0.93859612
69MP0008058_abnormal_DNA_repair0.93704409
70MP0002067_abnormal_sensory_capabilities0.93226695
71MP0003635_abnormal_synaptic_transmissio0.92512652
72MP0000230_abnormal_systemic_arterial0.92367431
73MP0002876_abnormal_thyroid_physiology0.92272024
74MP0002277_abnormal_respiratory_mucosa0.91763457
75MP0002751_abnormal_autonomic_nervous0.90131430
76MP0001502_abnormal_circadian_rhythm0.89566887
77MP0002063_abnormal_learning/memory/cond0.89131896
78MP0003646_muscle_fatigue0.89064519
79MP0003136_yellow_coat_color0.87728332
80MP0001919_abnormal_reproductive_system0.87418884
81MP0010329_abnormal_lipoprotein_level0.86528234
82MP0000613_abnormal_salivary_gland0.86281750
83MP0000015_abnormal_ear_pigmentation0.83855812
84MP0001984_abnormal_olfaction0.82636846
85MP0003283_abnormal_digestive_organ0.81447953
86MP0001944_abnormal_pancreas_morphology0.80268469
87MP0000383_abnormal_hair_follicle0.79140859
88MP0002229_neurodegeneration0.78235849
89MP0002184_abnormal_innervation0.78021463
90MP0001293_anophthalmia0.77841874
91MP0005423_abnormal_somatic_nervous0.76938305
92MP0004019_abnormal_vitamin_homeostasis0.74755374
93MP0005171_absent_coat_pigmentation0.73264816
94MP0005389_reproductive_system_phenotype0.72399799
95MP0004134_abnormal_chest_morphology0.69711286
96MP0005636_abnormal_mineral_homeostasis0.67888593
97MP0008995_early_reproductive_senescence0.65552123
98MP0001764_abnormal_homeostasis0.64330063
99MP0002928_abnormal_bile_duct0.59214753
100MP0002736_abnormal_nociception_after0.55925142
101MP0001324_abnormal_eye_pigmentation0.55636346
102MP0004036_abnormal_muscle_relaxation0.54997413
103MP0005253_abnormal_eye_physiology0.52889255
104MP0003115_abnormal_respiratory_system0.52665941
105MP0002971_abnormal_brown_adipose0.52461745
106MP0000462_abnormal_digestive_system0.49769456
107MP0001968_abnormal_touch/_nociception0.48148061
108MP0005551_abnormal_eye_electrophysiolog0.47005678
109MP0005391_vision/eye_phenotype0.46757743
110MP0002796_impaired_skin_barrier0.46335018
111MP0004270_analgesia0.45857017
112MP0003699_abnormal_female_reproductive0.45388920
113MP0008057_abnormal_DNA_replication0.45330408
114MP0003879_abnormal_hair_cell0.45161219
115MP0009115_abnormal_fat_cell0.44570989
116MP0003633_abnormal_nervous_system0.42070579
117MP0004133_heterotaxia0.39257500
118MP0000427_abnormal_hair_cycle0.36724759
119MP0006072_abnormal_retinal_apoptosis0.35919345
120MP0000920_abnormal_myelination0.35059237
121MP0005377_hearing/vestibular/ear_phenot0.34733302
122MP0003878_abnormal_ear_physiology0.34733302
123MP0003950_abnormal_plasma_membrane0.34061828
124MP0004381_abnormal_hair_follicle0.33138044
125MP0010094_abnormal_chromosome_stability0.32131867
126MP0009250_abnormal_appendicular_skeleto0.31447528
127MP0001986_abnormal_taste_sensitivity0.31307591
128MP0002092_abnormal_eye_morphology0.31147481
129MP0003786_premature_aging0.28871493
130MP0003959_abnormal_lean_body0.28765512
131MP0008569_lethality_at_weaning0.28275642
132MP0005397_hematopoietic_system_phenotyp0.27751670
133MP0001545_abnormal_hematopoietic_system0.27751670
134MP0003631_nervous_system_phenotype0.27006623
135MP0001119_abnormal_female_reproductive0.26790845
136MP0009278_abnormal_bone_marrow0.26203796
137MP0003329_amyloid_beta_deposits0.26043255
138MP0002638_abnormal_pupillary_reflex0.25854431
139MP0002132_abnormal_respiratory_system0.25837129
140MP0000685_abnormal_immune_system0.25499195
141MP0003252_abnormal_bile_duct0.24196127
142MP0004742_abnormal_vestibular_system0.23485815
143MP0000579_abnormal_nail_morphology0.23106294
144MP0002295_abnormal_pulmonary_circulatio0.23044244
145MP0002272_abnormal_nervous_system0.22948627
146MP0005075_abnormal_melanosome_morpholog0.22312109
147MP0002169_no_abnormal_phenotype0.21426776
148MP0002254_reproductive_system_inflammat0.21345713
149MP0002873_normal_phenotype0.21241891
150MP0000003_abnormal_adipose_tissue0.20781904
151MP0000647_abnormal_sebaceous_gland0.20567750
152MP0001963_abnormal_hearing_physiology0.19527565
153MP0003861_abnormal_nervous_system0.19480040
154MP0000432_abnormal_head_morphology0.18589713
155MP0003045_fibrosis0.17975586
156MP0005388_respiratory_system_phenotype0.17807783
157MP0002133_abnormal_respiratory_system0.17807783
158MP0002152_abnormal_brain_morphology0.17445990
159MP0005375_adipose_tissue_phenotype0.17383992
160MP0003948_abnormal_gas_homeostasis0.17106212
161MP0002734_abnormal_mechanical_nocicepti0.16757961
162MP0005195_abnormal_posterior_eye0.16742944
163MP0002233_abnormal_nose_morphology0.16077914
164MP0001440_abnormal_grooming_behavior0.14889130

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.64009904
2Abnormal respiratory motile cilium morphology (HP:0005938)9.13805157
3Abnormal respiratory epithelium morphology (HP:0012253)9.13805157
4Abnormal ciliary motility (HP:0012262)8.04881939
5Rhinitis (HP:0012384)7.57689454
6Chronic bronchitis (HP:0004469)7.30608024
7Infertility (HP:0000789)6.23075918
8Nasal polyposis (HP:0100582)6.01388297
9Abnormality of the nasal mucosa (HP:0000433)4.87505767
10Type II lissencephaly (HP:0007260)4.47805204
11Bronchitis (HP:0012387)4.42476845
12Bronchiectasis (HP:0002110)4.34005615
13Pancreatic cysts (HP:0001737)4.23992220
14Nephronophthisis (HP:0000090)4.17201654
15Male infertility (HP:0003251)4.14828831
16Recurrent sinusitis (HP:0011108)3.91577297
17Congenital stationary night blindness (HP:0007642)3.76408901
18Hyperventilation (HP:0002883)3.52413251
19Abnormal spermatogenesis (HP:0008669)3.32575136
20Abnormality of the renal medulla (HP:0100957)3.25167371
21Hypothermia (HP:0002045)3.23260399
22Recurrent otitis media (HP:0000403)3.14073689
23Mitochondrial inheritance (HP:0001427)2.99265073
24Cerebellar dysplasia (HP:0007033)2.94801198
25Tubulointerstitial nephritis (HP:0001970)2.94761574
26Acute necrotizing encephalopathy (HP:0006965)2.91711865
27Progressive macrocephaly (HP:0004481)2.74065598
28Increased CSF lactate (HP:0002490)2.73378797
29Attenuation of retinal blood vessels (HP:0007843)2.67285313
30Hepatic necrosis (HP:0002605)2.62114373
31Retinal dysplasia (HP:0007973)2.61928772
32Lissencephaly (HP:0001339)2.58944949
33Abnormal mitochondria in muscle tissue (HP:0008316)2.57208817
34Hepatocellular necrosis (HP:0001404)2.56739293
35Renal cortical cysts (HP:0000803)2.56659910
36Abolished electroretinogram (ERG) (HP:0000550)2.51439530
37Recurrent bronchitis (HP:0002837)2.50389392
38Acute encephalopathy (HP:0006846)2.48632573
39Abnormal rod and cone electroretinograms (HP:0008323)2.43975869
40Lipid accumulation in hepatocytes (HP:0006561)2.42339730
41Gonadotropin excess (HP:0000837)2.41699461
42Medial flaring of the eyebrow (HP:0010747)2.41267984
43Pendular nystagmus (HP:0012043)2.41170090
44Tubular atrophy (HP:0000092)2.38861222
45Chronic hepatic failure (HP:0100626)2.37578824
46Molar tooth sign on MRI (HP:0002419)2.37106022
47Abnormality of midbrain morphology (HP:0002418)2.37106022
48Abnormality of the pons (HP:0007361)2.36562350
49Pachygyria (HP:0001302)2.33240629
50Tubulointerstitial abnormality (HP:0001969)2.31576790
51Decreased central vision (HP:0007663)2.29007257
52Aplasia/hypoplasia of the uterus (HP:0008684)2.28950094
53Hypoplasia of the pons (HP:0012110)2.23550657
54Keratoconus (HP:0000563)2.21283976
55Increased corneal curvature (HP:0100692)2.21283976
56Azoospermia (HP:0000027)2.20989282
57Broad-based gait (HP:0002136)2.17462222
58Increased hepatocellular lipid droplets (HP:0006565)2.17219368
59Methylmalonic aciduria (HP:0012120)2.16596828
60Gaze-evoked nystagmus (HP:0000640)2.16227958
61Sclerocornea (HP:0000647)2.13810556
62Furrowed tongue (HP:0000221)2.08940209
63Oligodactyly (hands) (HP:0001180)2.08077016
64Methylmalonic acidemia (HP:0002912)2.07210006
65Optic disc pallor (HP:0000543)2.06500111
66Abnormality of the dental pulp (HP:0006479)2.05653273
67Inability to walk (HP:0002540)2.05402738
68Dyschromatopsia (HP:0007641)2.03873393
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6653198
70Dynein arm defect of respiratory motile cilia (HP:0012255)13.5024712
71Absent/shortened dynein arms (HP:0200106)13.5024712
72Decreased circulating renin level (HP:0003351)1.96331973
73Taurodontia (HP:0000679)1.96057942
74Abnormality of permanent molar morphology (HP:0011071)1.96057942
75Abnormality of the dental root (HP:0006486)1.96057942
76Fibular aplasia (HP:0002990)1.94985696
77Abnormality of the renal cortex (HP:0011035)1.94291222
78Postaxial foot polydactyly (HP:0001830)1.93071769
79Large for gestational age (HP:0001520)1.92155776
80Impulsivity (HP:0100710)1.91652697
81Severe muscular hypotonia (HP:0006829)1.90746747
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90695437
83Renal Fanconi syndrome (HP:0001994)1.90210486
84Hyperalaninemia (HP:0003348)1.89499513
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89499513
86Abnormality of alanine metabolism (HP:0010916)1.89499513
87Polyuria (HP:0000103)1.88735181
88Stomatitis (HP:0010280)1.88487805
89Anencephaly (HP:0002323)1.87890569
90Stage 5 chronic kidney disease (HP:0003774)1.87068911
91Abnormality of molar (HP:0011077)1.86765474
92Abnormality of molar morphology (HP:0011070)1.86765474
93Ketosis (HP:0001946)1.86438864
94Stomach cancer (HP:0012126)1.85651807
95Colon cancer (HP:0003003)1.85395938
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.85323592
97Congenital malformation of the right heart (HP:0011723)1.84908334
98Double outlet right ventricle (HP:0001719)1.84908334
99Abnormality of B cell number (HP:0010975)1.83356541
100Abnormality of dentin (HP:0010299)1.82645346
101Spastic tetraparesis (HP:0001285)1.81206064
102Increased serum lactate (HP:0002151)1.80060327
103Thyroiditis (HP:0100646)1.79554736
104Congenital hepatic fibrosis (HP:0002612)1.79216243
105Glycosuria (HP:0003076)1.78974131
106Abnormality of urine glucose concentration (HP:0011016)1.78974131
107Febrile seizures (HP:0002373)1.78945681
108Hemiparesis (HP:0001269)1.78937197
109Abnormality of the labia minora (HP:0012880)1.78774272
110Bell-shaped thorax (HP:0001591)1.77838143
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.77573605
112Tubulointerstitial fibrosis (HP:0005576)1.76426743
113Focal motor seizures (HP:0011153)1.74695251
114Fibular hypoplasia (HP:0003038)1.74642724
115Abnormality of renal excretion (HP:0011036)1.73578580
116Male pseudohermaphroditism (HP:0000037)1.73125591
117Absent speech (HP:0001344)1.71967351
118Microglossia (HP:0000171)1.70823020
119Hypomagnesemia (HP:0002917)1.70643161
120Cerebral edema (HP:0002181)1.70618070
121Polydipsia (HP:0001959)1.69830519
122Abnormal drinking behavior (HP:0030082)1.69830519
1233-Methylglutaconic aciduria (HP:0003535)1.69823004
124Abnormal albumin level (HP:0012116)1.68355105
125Hypoalbuminemia (HP:0003073)1.68355105
126Bony spicule pigmentary retinopathy (HP:0007737)1.67745238
127Ketoacidosis (HP:0001993)1.66289396
128Heterotopia (HP:0002282)1.63160332
129Choroideremia (HP:0001139)1.62906409
130Vascular calcification (HP:0004934)1.59398998
131Renal dysplasia (HP:0000110)1.52147928
132Pancreatic fibrosis (HP:0100732)1.49481246
133Absent frontal sinuses (HP:0002688)1.48184766
134Postaxial hand polydactyly (HP:0001162)1.46679000
135Short ribs (HP:0000773)1.46240512
136Cholecystitis (HP:0001082)1.45846806
137Abnormal gallbladder physiology (HP:0012438)1.45846806
138Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.44797512
139Cardiovascular calcification (HP:0011915)1.44109223
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.44102391
141Chronic sinusitis (HP:0011109)1.43876642
142Asymmetric septal hypertrophy (HP:0001670)1.42223539
143Hypoplasia of dental enamel (HP:0006297)1.41902166
144Cystic liver disease (HP:0006706)1.41379407
145Optic nerve hypoplasia (HP:0000609)1.40900441
146J-shaped sella turcica (HP:0002680)1.39901702
147Facial cleft (HP:0002006)1.39840686
148Tongue fasciculations (HP:0001308)1.39399622
149True hermaphroditism (HP:0010459)1.36934396
150Median cleft lip (HP:0000161)1.35790445
151Abnormality of the lower motor neuron (HP:0002366)1.34046036
152Gait imbalance (HP:0002141)1.32791668
153Bile duct proliferation (HP:0001408)1.32223075
154Abnormal biliary tract physiology (HP:0012439)1.32223075
155Congenital primary aphakia (HP:0007707)1.29832959
156Aplasia/Hypoplasia of the lens (HP:0008063)1.29209310
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.27811874
158Neurofibrillary tangles (HP:0002185)1.27730819
159Abnormal urine output (HP:0012590)1.26385129
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.24835376
161Muscle fibrillation (HP:0010546)1.23994437
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.23744379
163Nephropathy (HP:0000112)1.23006371
164Constricted visual fields (HP:0001133)1.21759042
165Oculomotor apraxia (HP:0000657)1.18410226
166Amyotrophic lateral sclerosis (HP:0007354)1.17304974
167Cone-rod dystrophy (HP:0000548)1.17281612
168Peripheral hypomyelination (HP:0007182)1.16947703
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.16282803
170Short thorax (HP:0010306)1.15953999
171Abnormal connection of the cardiac segments (HP:0011545)1.15784140
172Abnormal ventriculo-arterial connection (HP:0011563)1.15784140
173Transposition of the great arteries (HP:0001669)1.15784140
174Upper limb muscle weakness (HP:0003484)1.11929168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.15803650
2PDK49.15803650
3PDK26.06899225
4FRK4.79377703
5TESK14.65753684
6MAP4K23.96281902
7PRKD33.61767250
8ICK3.27561224
9ADRBK22.97298331
10ZAK2.89314137
11GRK12.75799030
12STK392.59440727
13WNK42.39351123
14NUAK12.32117267
15PTK2B2.11633633
16TAOK32.07400332
17MAPK131.96909041
18TLK11.94479959
19MAP3K41.79099805
20TNIK1.74027864
21PNCK1.73776866
22MST41.63247123
23DAPK21.51475236
24ACVR1B1.49405546
25STK381.45986844
26VRK21.45397163
27DYRK21.35296758
28VRK11.33800168
29TRIM281.27539305
30BCKDK1.25569397
31CSNK1G11.22386831
32MKNK21.22029318
33INSRR1.20048898
34DYRK1B1.18643899
35PDK11.14314473
36MAP3K91.14114755
37TXK1.12212077
38NLK1.10903282
39PAK31.10591396
40ADRBK11.10183560
41CSNK1G31.08811775
42NEK21.08479830
43CSNK1G21.08289646
44TGFBR11.02459821
45PRKCE1.01150437
46WNK10.94289439
47TEC0.87331942
48PLK20.84959510
49PLK30.83616102
50LMTK20.82767713
51NTRK30.80637332
52CSNK1A1L0.78622563
53TSSK60.78553158
54CAMK1G0.76172617
55CDK80.75415100
56NME10.74919810
57EIF2AK30.74523195
58PRKCI0.71526368
59FGFR20.71059568
60ERBB30.68461006
61CAMKK20.67948516
62GRK50.67610277
63MAPK150.63454505
64TYRO30.59356130
65ITK0.59095511
66IRAK10.58231371
67CSNK1A10.58057431
68BCR0.57964414
69PDPK10.57640427
70TRPM70.57348362
71DYRK30.57328483
72MAP2K60.56085887
73NTRK20.55182017
74TNK20.54361234
75PASK0.53557736
76CASK0.52758525
77PKN10.52132238
78IKBKB0.51604170
79RPS6KA50.51523125
80STK38L0.49373124
81GRK70.47653347
82CHEK20.46777753
83PINK10.45580058
84TTK0.43794246
85STK240.43015789
86STK30.42938560
87MAPKAPK30.42883773
88TIE10.42607730
89EPHA40.41450670
90CCNB10.41226071
91SGK20.40121384
92KIT0.36542705
93CHEK10.35852893
94SYK0.35573317
95CAMK40.32530129
96FER0.32492461
97AKT30.32315960
98EPHA30.31735037
99RIPK40.31011247
100PAK10.30587209
101MAP3K140.30103697
102ATM0.28904685
103WNK30.27600638
104PRKCQ0.26665733
105WEE10.24936940
106MAPKAPK50.24473235
107EPHA20.24415389
108OXSR10.23706922
109ATR0.23672961
110PRKCG0.22637909
111MUSK0.22510292
112NEK60.22065214
113MAP2K70.21123637
114BRSK20.21002837
115PLK40.20991137
116CAMK2A0.20044115
117MARK20.17380192
118OBSCN0.17208147
119BRAF0.15944759
120CAMK1D0.15941821
121PAK20.15922212
122PRKAA10.15401733
123BMPR1B0.15329347
124IRAK20.13799630
125PHKG10.12712113
126PHKG20.12712113
127PRKCZ0.12604734
128MTOR0.11581315
129PIK3CG0.11174680
130PLK10.09684667
131MARK30.09556704
132CAMKK10.09445341
133EEF2K0.09234949
134RPS6KB10.08982953
135PRKG10.08913482
136PRKACG0.08564933
137STK100.08105562
138CSNK2A20.07715640
139BRSK10.07563003
140PRKG20.07083344
141PRKDC0.06704975
142CSNK2A10.06533292
143GSK3B0.06443496
144CSNK1E0.05952072
145MARK10.05706064
146CSNK1D0.05691308
147PRKACA0.05511426
148EIF2AK20.05003572
149PRKCA0.04712726
150PRKCD0.04522123
151CDC42BPA0.04138520
152CAMK10.03809267
153GSK3A0.03644075
154NTRK10.03577150
155TESK20.03342883
156CAMK2G0.03272799
157CAMK2B0.03254866
158PRKCB0.03225001
159MAPK80.02853603
160PRKACB0.02585088
161EGFR0.02560509
162CAMK2D0.02560253
163SRC0.02040364

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.09819757
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.02155076
3Pyruvate metabolism_Homo sapiens_hsa006203.81212027
4Fatty acid biosynthesis_Homo sapiens_hsa000613.58163951
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.07786949
6Propanoate metabolism_Homo sapiens_hsa006403.00286213
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91230529
8Linoleic acid metabolism_Homo sapiens_hsa005912.89568010
9Oxidative phosphorylation_Homo sapiens_hsa001902.72875692
10Glucagon signaling pathway_Homo sapiens_hsa049222.62228286
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.58002165
12Protein export_Homo sapiens_hsa030602.43207846
13Butanoate metabolism_Homo sapiens_hsa006502.34256729
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28913578
15Basal transcription factors_Homo sapiens_hsa030222.26326069
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.24524154
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23752792
18Pentose phosphate pathway_Homo sapiens_hsa000302.14234398
19Homologous recombination_Homo sapiens_hsa034402.13632707
20Parkinsons disease_Homo sapiens_hsa050122.11654755
21Nitrogen metabolism_Homo sapiens_hsa009102.10048877
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04348593
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99508001
24Proteasome_Homo sapiens_hsa030501.97550223
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97423255
26Glycerolipid metabolism_Homo sapiens_hsa005611.96673743
27Ether lipid metabolism_Homo sapiens_hsa005651.91236125
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89823008
29Mineral absorption_Homo sapiens_hsa049781.81876407
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74398439
31Fanconi anemia pathway_Homo sapiens_hsa034601.72934791
32RNA polymerase_Homo sapiens_hsa030201.72203057
33Nicotine addiction_Homo sapiens_hsa050331.71942188
34Amphetamine addiction_Homo sapiens_hsa050311.71528669
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71458405
36Tryptophan metabolism_Homo sapiens_hsa003801.71226536
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.70525826
38PPAR signaling pathway_Homo sapiens_hsa033201.67397304
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59672358
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.55937384
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54846948
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54752908
43Oocyte meiosis_Homo sapiens_hsa041141.54703569
44One carbon pool by folate_Homo sapiens_hsa006701.48015377
45Dorso-ventral axis formation_Homo sapiens_hsa043201.47537149
46Primary immunodeficiency_Homo sapiens_hsa053401.46418831
47Peroxisome_Homo sapiens_hsa041461.45600428
48Selenocompound metabolism_Homo sapiens_hsa004501.38030785
49Renin secretion_Homo sapiens_hsa049241.37163048
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30050349
51Cardiac muscle contraction_Homo sapiens_hsa042601.28575365
52Alzheimers disease_Homo sapiens_hsa050101.24152611
53Carbon metabolism_Homo sapiens_hsa012001.22796856
54RNA degradation_Homo sapiens_hsa030181.22648901
55Fat digestion and absorption_Homo sapiens_hsa049751.22356961
56Huntingtons disease_Homo sapiens_hsa050161.21115698
57Caffeine metabolism_Homo sapiens_hsa002321.19482239
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18363315
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16737643
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.09752030
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07943210
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04784977
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02712659
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.00860736
65Morphine addiction_Homo sapiens_hsa050320.98354631
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95297363
67Fructose and mannose metabolism_Homo sapiens_hsa000510.94907814
68Fatty acid metabolism_Homo sapiens_hsa012120.94176373
69Regulation of autophagy_Homo sapiens_hsa041400.93730206
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93655485
71Purine metabolism_Homo sapiens_hsa002300.93399426
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92383880
73Glutathione metabolism_Homo sapiens_hsa004800.90658511
74Fatty acid degradation_Homo sapiens_hsa000710.90401793
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88808713
76Long-term potentiation_Homo sapiens_hsa047200.88377011
77Taste transduction_Homo sapiens_hsa047420.87531666
78Asthma_Homo sapiens_hsa053100.87205992
79Non-homologous end-joining_Homo sapiens_hsa034500.86593413
80Calcium signaling pathway_Homo sapiens_hsa040200.85259124
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84152345
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.84102504
83Collecting duct acid secretion_Homo sapiens_hsa049660.82359129
84Antigen processing and presentation_Homo sapiens_hsa046120.81843745
85Biosynthesis of amino acids_Homo sapiens_hsa012300.78821219
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78716731
87Folate biosynthesis_Homo sapiens_hsa007900.78574037
88Type I diabetes mellitus_Homo sapiens_hsa049400.77446469
89Arachidonic acid metabolism_Homo sapiens_hsa005900.75829810
90Chemical carcinogenesis_Homo sapiens_hsa052040.73513119
91Insulin secretion_Homo sapiens_hsa049110.73132364
92Thyroid hormone synthesis_Homo sapiens_hsa049180.72809791
93ABC transporters_Homo sapiens_hsa020100.71299003
94Pyrimidine metabolism_Homo sapiens_hsa002400.69423853
95Inositol phosphate metabolism_Homo sapiens_hsa005620.68353006
96Salivary secretion_Homo sapiens_hsa049700.68244101
97Estrogen signaling pathway_Homo sapiens_hsa049150.66650774
98Serotonergic synapse_Homo sapiens_hsa047260.65753397
99Hedgehog signaling pathway_Homo sapiens_hsa043400.63572333
100beta-Alanine metabolism_Homo sapiens_hsa004100.63477071
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63308536
102Ovarian steroidogenesis_Homo sapiens_hsa049130.62140996
103GABAergic synapse_Homo sapiens_hsa047270.61872030
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61541790
105Renin-angiotensin system_Homo sapiens_hsa046140.61417003
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60409959
107Bile secretion_Homo sapiens_hsa049760.60373533
108Steroid biosynthesis_Homo sapiens_hsa001000.59465276
109Pancreatic secretion_Homo sapiens_hsa049720.59192710
110cAMP signaling pathway_Homo sapiens_hsa040240.57162093
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56891423
112Cocaine addiction_Homo sapiens_hsa050300.56776450
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54471521
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54341965
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54146537
116mRNA surveillance pathway_Homo sapiens_hsa030150.52876432
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52298003
118Histidine metabolism_Homo sapiens_hsa003400.51068810
119Gastric acid secretion_Homo sapiens_hsa049710.50782545
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50346160
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50149971
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.47223376
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47051420
124Fatty acid elongation_Homo sapiens_hsa000620.46412386
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46069291
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.43992975
127Sulfur metabolism_Homo sapiens_hsa009200.43443306
128Metabolic pathways_Homo sapiens_hsa011000.41278427
129Systemic lupus erythematosus_Homo sapiens_hsa053220.41007303
130Dopaminergic synapse_Homo sapiens_hsa047280.40562349
131Protein digestion and absorption_Homo sapiens_hsa049740.39335225
132Synaptic vesicle cycle_Homo sapiens_hsa047210.38676310
133Retinol metabolism_Homo sapiens_hsa008300.38550326
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38545324
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38465003
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.38433651
137Vitamin digestion and absorption_Homo sapiens_hsa049770.37513076
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.37021265
139Endocytosis_Homo sapiens_hsa041440.36283580
140Circadian entrainment_Homo sapiens_hsa047130.35120480
141Circadian rhythm_Homo sapiens_hsa047100.35084194
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32511521
143Glutamatergic synapse_Homo sapiens_hsa047240.32411271
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30775056
145Sphingolipid metabolism_Homo sapiens_hsa006000.30470767
146Wnt signaling pathway_Homo sapiens_hsa043100.30162432
147Basal cell carcinoma_Homo sapiens_hsa052170.27141083
148Olfactory transduction_Homo sapiens_hsa047400.25444480
149VEGF signaling pathway_Homo sapiens_hsa043700.24719620
150Tight junction_Homo sapiens_hsa045300.24559828
151B cell receptor signaling pathway_Homo sapiens_hsa046620.23433798
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.22931422
153RNA transport_Homo sapiens_hsa030130.22630391
154Salmonella infection_Homo sapiens_hsa051320.22351632
155Legionellosis_Homo sapiens_hsa051340.21285373
156Phototransduction_Homo sapiens_hsa047440.20105734
157Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18361902

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »