SPACA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.87974631
2regulation of cilium movement (GO:0003352)9.87190064
3acrosome assembly (GO:0001675)9.61374952
4motile cilium assembly (GO:0044458)9.25080412
5cilium movement (GO:0003341)9.23336003
6cilium or flagellum-dependent cell motility (GO:0001539)9.19152226
7binding of sperm to zona pellucida (GO:0007339)9.14148227
8multicellular organism reproduction (GO:0032504)9.01759029
9cell-cell recognition (GO:0009988)8.80909657
10spermatid development (GO:0007286)8.71194959
11plasma membrane fusion (GO:0045026)8.64515351
12reproduction (GO:0000003)7.72442292
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.34400190
14ventricular system development (GO:0021591)7.01164045
15sperm capacitation (GO:0048240)6.62583747
16organic cation transport (GO:0015695)6.57387698
17single fertilization (GO:0007338)6.54892325
18negative regulation of inclusion body assembly (GO:0090084)6.50091909
19neuron fate determination (GO:0048664)6.18674033
20piRNA metabolic process (GO:0034587)5.99692167
21spermatogenesis (GO:0007283)5.98983708
22male gamete generation (GO:0048232)5.96701238
23synaptonemal complex organization (GO:0070193)5.89442609
24regulation of microtubule-based movement (GO:0060632)5.80667249
25synaptonemal complex assembly (GO:0007130)5.67890214
26male meiosis (GO:0007140)5.64665688
27fertilization (GO:0009566)5.58440426
28microtubule depolymerization (GO:0007019)5.55795044
29regulation of inclusion body assembly (GO:0090083)5.54776466
30microtubule severing (GO:0051013)5.50999718
31gamete generation (GO:0007276)5.46097663
32chromosome condensation (GO:0030261)5.20000315
33DNA packaging (GO:0006323)4.87741377
34germ cell development (GO:0007281)4.82063325
35microtubule polymerization or depolymerization (GO:0031109)4.76956841
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.65847561
37protein polyglutamylation (GO:0018095)4.40753460
38nucleoside diphosphate phosphorylation (GO:0006165)4.38863709
39doxorubicin metabolic process (GO:0044598)4.35386083
40daunorubicin metabolic process (GO:0044597)4.35386083
41polyketide metabolic process (GO:0030638)4.35386083
42seminiferous tubule development (GO:0072520)4.33304361
43behavioral response to nicotine (GO:0035095)4.32802590
44multicellular organismal reproductive process (GO:0048609)4.32250663
45regulation of response to osmotic stress (GO:0047484)4.32050290
46male meiosis I (GO:0007141)4.28019665
47calcium ion-dependent exocytosis (GO:0017156)4.24930437
48cell recognition (GO:0008037)4.10975790
49glycerol ether metabolic process (GO:0006662)4.09584201
50left/right pattern formation (GO:0060972)4.02558185
51negative regulation of cell aging (GO:0090344)4.02494296
52axoneme assembly (GO:0035082)3.99990029
53protein localization to cilium (GO:0061512)3.96987743
54spermatid nucleus differentiation (GO:0007289)3.96150994
55GTP biosynthetic process (GO:0006183)3.96118784
56chromosome organization involved in meiosis (GO:0070192)3.85729101
57ether metabolic process (GO:0018904)3.75778303
58hematopoietic stem cell proliferation (GO:0071425)3.70287370
59UTP biosynthetic process (GO:0006228)3.65516116
60meiotic cell cycle (GO:0051321)3.61947233
61sequestering of actin monomers (GO:0042989)3.61463216
62positive regulation of embryonic development (GO:0040019)3.61184442
63meiotic nuclear division (GO:0007126)3.60331583
64single strand break repair (GO:0000012)3.60057571
65nonmotile primary cilium assembly (GO:0035058)3.58172054
66cilium morphogenesis (GO:0060271)3.53033373
67multicellular organismal development (GO:0007275)3.50084748
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50060407
69midbrain development (GO:0030901)3.49666583
70RNA localization (GO:0006403)3.49063888
71DNA methylation involved in gamete generation (GO:0043046)3.47126952
72protein localization to chromosome, centromeric region (GO:0071459)3.39814437
73meiosis I (GO:0007127)3.38785886
74chaperone-mediated protein complex assembly (GO:0051131)3.36238526
75left/right axis specification (GO:0070986)3.35498330
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32808698
77ATP synthesis coupled proton transport (GO:0015986)3.32808698
78aldehyde catabolic process (GO:0046185)3.31958865
79spinal cord association neuron differentiation (GO:0021527)3.31749926
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31468675
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.31468675
82NADH dehydrogenase complex assembly (GO:0010257)3.31468675
83genitalia morphogenesis (GO:0035112)3.28282171
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27484472
85protein complex biogenesis (GO:0070271)3.25163643
86glycolytic process (GO:0006096)3.25052182
87CTP metabolic process (GO:0046036)3.23124325
88CTP biosynthetic process (GO:0006241)3.23124325
89positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.22773383
90UTP metabolic process (GO:0046051)3.21530174
91sexual reproduction (GO:0019953)3.19833709
92cell differentiation in spinal cord (GO:0021515)3.12225117
93cilium organization (GO:0044782)3.10472251
94nucleus organization (GO:0006997)3.10276683
95nuclear pore complex assembly (GO:0051292)3.09069888
96interferon-gamma secretion (GO:0072643)3.08729872
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05548666
98hepatocyte differentiation (GO:0070365)3.03302930
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02135557
100microtubule bundle formation (GO:0001578)3.01221654
101negative regulation of T cell differentiation in thymus (GO:0033085)3.00829844
102mitochondrial respiratory chain complex assembly (GO:0033108)2.99939015
103cilium assembly (GO:0042384)2.97330784
104fucose catabolic process (GO:0019317)2.96421409
105L-fucose metabolic process (GO:0042354)2.96421409
106L-fucose catabolic process (GO:0042355)2.96421409
107smoothened signaling pathway (GO:0007224)2.93842022
108neuronal action potential (GO:0019228)2.93604048
109intraciliary transport (GO:0042073)2.89867503
110heterochromatin organization (GO:0070828)2.89497568
111regulation of spindle checkpoint (GO:0090231)2.88591904
112platelet dense granule organization (GO:0060155)2.84985703
113regulation of cilium assembly (GO:1902017)2.84938330
114spinal cord motor neuron differentiation (GO:0021522)2.83021621
115cellular component assembly involved in morphogenesis (GO:0010927)2.81653566
116electron transport chain (GO:0022900)2.80471088
117mitochondrion degradation (GO:0000422)2.80306919
118protein refolding (GO:0042026)2.76461162
119pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.76307175
120determination of left/right symmetry (GO:0007368)2.75820286
121guanosine-containing compound biosynthetic process (GO:1901070)2.75408805
122microtubule-based movement (GO:0007018)2.74486463
123neuronal stem cell maintenance (GO:0097150)2.72410583
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72224400
125respiratory electron transport chain (GO:0022904)2.69917059
126DNA replication-dependent nucleosome organization (GO:0034723)2.68609577
127DNA replication-dependent nucleosome assembly (GO:0006335)2.68609577
128aminoglycoside antibiotic metabolic process (GO:0030647)2.68522583
129establishment of tissue polarity (GO:0007164)2.67803440
130establishment of planar polarity (GO:0001736)2.67803440
131membrane protein intracellular domain proteolysis (GO:0031293)2.67506224
132positive regulation of gastrulation (GO:2000543)2.65412571
133cornea development in camera-type eye (GO:0061303)2.64072150
134protein K11-linked deubiquitination (GO:0035871)2.61133901
135presynaptic membrane assembly (GO:0097105)2.60952795
136water-soluble vitamin biosynthetic process (GO:0042364)2.60220595
137mitotic sister chromatid cohesion (GO:0007064)2.59348413
138cellular ketone body metabolic process (GO:0046950)2.57396908
139pyrimidine nucleobase catabolic process (GO:0006208)2.57237997
140determination of bilateral symmetry (GO:0009855)2.57053231
141response to pheromone (GO:0019236)2.57010677
142negative regulation of telomere maintenance (GO:0032205)2.56731288
143transmission of nerve impulse (GO:0019226)2.54618499
144cell projection assembly (GO:0030031)2.54579383
145viral transcription (GO:0019083)2.52443547
146centriole replication (GO:0007099)2.51195159
147neurotransmitter catabolic process (GO:0042135)2.50936709
148specification of symmetry (GO:0009799)2.49445567
149retinal ganglion cell axon guidance (GO:0031290)2.48640199
150positive regulation of Notch signaling pathway (GO:0045747)2.46634002
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.46008051
152translational termination (GO:0006415)2.44462689
153presynaptic membrane organization (GO:0097090)2.41730243
154photoreceptor cell maintenance (GO:0045494)2.41299925
155centriole assembly (GO:0098534)2.39946764
156primary amino compound metabolic process (GO:1901160)2.38252997
157gamma-aminobutyric acid transport (GO:0015812)2.36756600
158neurotransmitter metabolic process (GO:0042133)2.36429301
159oligosaccharide biosynthetic process (GO:0009312)2.36412412
160indolalkylamine metabolic process (GO:0006586)2.35759404
161thalamus development (GO:0021794)2.35124068
162retinal cone cell development (GO:0046549)2.34600942
163exogenous drug catabolic process (GO:0042738)2.33343691
164lateral sprouting from an epithelium (GO:0060601)2.32899315
165phenol-containing compound catabolic process (GO:0019336)2.32597466
166detection of light stimulus involved in sensory perception (GO:0050962)2.32062894
167detection of light stimulus involved in visual perception (GO:0050908)2.32062894
168positive regulation of oligodendrocyte differentiation (GO:0048714)2.30375877
169somite development (GO:0061053)2.30133621
170nephron tubule morphogenesis (GO:0072078)2.29973840
171sperm motility (GO:0030317)12.5790458
172fusion of sperm to egg plasma membrane (GO:0007342)11.5460307
173cell wall macromolecule metabolic process (GO:0044036)10.7231200
174cell wall macromolecule catabolic process (GO:0016998)10.7231200
175acrosome reaction (GO:0007340)10.4955515
176epithelial cilium movement (GO:0003351)10.1848579
177axonemal dynein complex assembly (GO:0070286)10.1582210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.61831539
2ZNF274_21170338_ChIP-Seq_K562_Hela3.34423004
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.14145021
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84415031
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84408655
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.74092757
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60579851
8GBX2_23144817_ChIP-Seq_PC3_Human2.45378748
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35494967
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34768586
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22989135
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.21606917
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21321608
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19572268
15VDR_22108803_ChIP-Seq_LS180_Human2.16359586
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16185368
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13714527
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.09229832
19EZH2_22144423_ChIP-Seq_EOC_Human2.03594413
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02541269
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01274924
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01247684
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97214016
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95153010
25FUS_26573619_Chip-Seq_HEK293_Human1.92363861
26EWS_26573619_Chip-Seq_HEK293_Human1.88399617
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84677548
28TAF15_26573619_Chip-Seq_HEK293_Human1.82166252
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79138126
30GATA3_21867929_ChIP-Seq_CD8_Mouse1.76973238
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75062566
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73122368
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72881257
34P300_19829295_ChIP-Seq_ESCs_Human1.69651128
35RNF2_27304074_Chip-Seq_NSC_Mouse1.68827345
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.67458697
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.67383960
38SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63122893
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61863200
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61229037
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55996432
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55996432
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55996432
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.55946650
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55310547
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55310547
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55083146
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54697182
49REST_21632747_ChIP-Seq_MESCs_Mouse1.54299634
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52119096
51CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52075239
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.51981819
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47264699
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.46749628
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46521942
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.45932039
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.45083363
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44758916
59AR_25329375_ChIP-Seq_VCAP_Human1.44549398
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43878126
61SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43676662
62MYC_18940864_ChIP-ChIP_HL60_Human1.43024431
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42877952
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41691731
65BCOR_27268052_Chip-Seq_Bcells_Human1.40953567
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.39725738
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39494422
68SPI1_26923725_Chip-Seq_HPCs_Mouse1.37807644
69ER_23166858_ChIP-Seq_MCF-7_Human1.37765521
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37359476
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37196814
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37099090
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35460473
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34871361
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34540786
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33652315
77IGF1R_20145208_ChIP-Seq_DFB_Human1.33529563
78AR_21572438_ChIP-Seq_LNCaP_Human1.33059773
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.32378965
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32321195
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32307121
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31500001
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.31116728
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31010077
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30600070
86SMAD4_21799915_ChIP-Seq_A2780_Human1.30466736
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.30375162
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.29420401
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29420401
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.28744363
91RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28312624
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28093988
93WDR5_24793694_ChIP-Seq_LNCAP_Human1.27905923
94P53_21459846_ChIP-Seq_SAOS-2_Human1.27208731
95SOX2_19829295_ChIP-Seq_ESCs_Human1.26557627
96NANOG_19829295_ChIP-Seq_ESCs_Human1.26557627
97STAT1_17558387_ChIP-Seq_HELA_Human1.25065182
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24552351
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24260551
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23997740
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22501486
102CTCF_20526341_ChIP-Seq_ESCs_Human1.22413658
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21548520
104TCF4_22108803_ChIP-Seq_LS180_Human1.21529542
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21118862
106DROSHA_22980978_ChIP-Seq_HELA_Human1.20376947
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19755405
108STAT3_23295773_ChIP-Seq_U87_Human1.18923567
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.18427693
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.18393346
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.17484585
112ERG_20517297_ChIP-Seq_VCAP_Human1.17463974
113BCAT_22108803_ChIP-Seq_LS180_Human1.16787178
114PHF8_20622854_ChIP-Seq_HELA_Human1.16664612
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16600615
116ESET_19884257_ChIP-Seq_ESCs_Mouse1.16395436
117SMC4_20622854_ChIP-Seq_HELA_Human1.16105717
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15921842
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15774323
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15759850
121TP53_22573176_ChIP-Seq_HFKS_Human1.14911749
122EST1_17652178_ChIP-ChIP_JURKAT_Human1.14270184
123RNF2_27304074_Chip-Seq_ESCs_Mouse1.14260267
124MYC_27129775_Chip-Seq_CORNEA_Mouse1.13365262
125AR_20517297_ChIP-Seq_VCAP_Human1.13266910
126BCL6_27268052_Chip-Seq_Bcells_Human1.12244140
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11677241
128KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11080115
129CBP_20019798_ChIP-Seq_JUKART_Human1.11057035
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11057035
131TCF4_23295773_ChIP-Seq_U87_Human1.10872966
132CTCF_26484167_Chip-Seq_Bcells_Mouse1.10098782
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.09928688
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09640018
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09616440
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09572006
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09487757
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09435222
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08815311
140RARA_24833708_ChIP-Seq_LIVER_Mouse1.08119982
141GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08063215
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07977132
143E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07771379
144RUNX2_22187159_ChIP-Seq_PCA_Human1.07487745
145CSB_26484114_Chip-Seq_FIBROBLAST_Human1.07289286
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07225480
147NANOG_20526341_ChIP-Seq_ESCs_Human1.06716839
148SMAD4_21741376_ChIP-Seq_EPCs_Human1.06201943
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06170785
150NCOR_22424771_ChIP-Seq_293T_Human1.05898182
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04638322
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04312902
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04145001
154GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03848138
155SPI1_20517297_ChIP-Seq_HL60_Human1.02610396
156STAT1_20625510_ChIP-Seq_HELA_Human1.02201226
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02176713
158MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02147589
159STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00942479
160MYC_19829295_ChIP-Seq_ESCs_Human1.00582234
161FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00458437
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00292518
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00080881
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.99961642
165SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99610794
166SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98349177
167LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98330479
168FLI1_21867929_ChIP-Seq_CD8_Mouse0.96948742
169CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96868320
170HOXB7_26014856_ChIP-Seq_BT474_Human0.96165600
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96074965
172TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95565890
173IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94437687
174CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94410436
175IRF1_19129219_ChIP-ChIP_H3396_Human0.94313079
176KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94069044
177CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93483266
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93431523
179RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92942456
180EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92942456
181GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92935240
182RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91906208
183MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91762336
184GF1_26923725_Chip-Seq_HPCs_Mouse0.91758531
185KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91728665
186SCL_19346495_ChIP-Seq_HPC-7_Human0.91534235
187SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88326989
188TP63_22573176_ChIP-Seq_HFKS_Human0.88286950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.19782340
2MP0001929_abnormal_gametogenesis4.77550135
3MP0003011_delayed_dark_adaptation3.91507453
4MP0000566_synostosis3.38095642
5MP0002653_abnormal_ependyma_morphology3.19528229
6MP0008875_abnormal_xenobiotic_pharmacok3.17590716
7MP0002161_abnormal_fertility/fecundity2.80142583
8MP0002210_abnormal_sex_determination2.76136135
9MP0004142_abnormal_muscle_tone2.71685569
10MP0008877_abnormal_DNA_methylation2.68657929
11MP0004742_abnormal_vestibular_system2.56788696
12MP0001145_abnormal_male_reproductive2.48203750
13MP0009379_abnormal_foot_pigmentation2.27234324
14MP0005670_abnormal_white_adipose2.12377052
15MP0005551_abnormal_eye_electrophysiolog2.08638706
16MP0003283_abnormal_digestive_organ2.04269588
17MP0005410_abnormal_fertilization14.5698975
18MP0000653_abnormal_sex_gland1.99981593
19MP0001485_abnormal_pinna_reflex1.99902820
20MP0002938_white_spotting1.98938051
21MP0003880_abnormal_central_pattern1.96113433
22MP0002638_abnormal_pupillary_reflex1.95605499
23MP0005075_abnormal_melanosome_morpholog1.86737231
24MP0010030_abnormal_orbit_morphology1.85468303
25MP0004264_abnormal_extraembryonic_tissu1.84922212
26MP0002102_abnormal_ear_morphology1.83423562
27MP0002249_abnormal_larynx_morphology1.77542812
28MP0009745_abnormal_behavioral_response1.73113895
29MP0001968_abnormal_touch/_nociception1.70562325
30MP0006276_abnormal_autonomic_nervous1.60020084
31MP0006292_abnormal_olfactory_placode1.59478870
32MP0002735_abnormal_chemical_nociception1.59365374
33MP0001486_abnormal_startle_reflex1.58240815
34MP0009046_muscle_twitch1.58167435
35MP0004885_abnormal_endolymph1.56560264
36MP0000026_abnormal_inner_ear1.52502659
37MP0002272_abnormal_nervous_system1.51995639
38MP0002736_abnormal_nociception_after1.50911375
39MP0000778_abnormal_nervous_system1.49635573
40MP0001529_abnormal_vocalization1.49622962
41MP0004043_abnormal_pH_regulation1.48731066
42MP0000631_abnormal_neuroendocrine_gland1.46196423
43MP0002876_abnormal_thyroid_physiology1.44063776
44MP0003195_calcinosis1.43184214
45MP0005623_abnormal_meninges_morphology1.43147672
46MP0006082_CNS_inflammation1.41980379
47MP0000569_abnormal_digit_pigmentation1.41343857
48MP0002572_abnormal_emotion/affect_behav1.40404711
49MP0008789_abnormal_olfactory_epithelium1.39645643
50MP0002557_abnormal_social/conspecific_i1.38672856
51MP0006072_abnormal_retinal_apoptosis1.34481515
52MP0002254_reproductive_system_inflammat1.32781356
53MP0001905_abnormal_dopamine_level1.32023824
54MP0002234_abnormal_pharynx_morphology1.28536137
55MP0000372_irregular_coat_pigmentation1.27543413
56MP0003878_abnormal_ear_physiology1.27265047
57MP0005377_hearing/vestibular/ear_phenot1.27265047
58MP0008057_abnormal_DNA_replication1.27008504
59MP0002160_abnormal_reproductive_system1.26541119
60MP0000383_abnormal_hair_follicle1.24296656
61MP0001970_abnormal_pain_threshold1.24107399
62MP0002064_seizures1.21261147
63MP0002734_abnormal_mechanical_nocicepti1.20089177
64MP0005646_abnormal_pituitary_gland1.19165821
65MP0008872_abnormal_physiological_respon1.19150832
66MP0001986_abnormal_taste_sensitivity1.18469421
67MP0005423_abnormal_somatic_nervous1.17453329
68MP0002837_dystrophic_cardiac_calcinosis1.17100665
69MP0002132_abnormal_respiratory_system1.16699069
70MP0002063_abnormal_learning/memory/cond1.14361250
71MP0005645_abnormal_hypothalamus_physiol1.12810942
72MP0003183_abnormal_peptide_metabolism1.10118545
73MP0005195_abnormal_posterior_eye1.08803375
74MP0001835_abnormal_antigen_presentation1.08709574
75MP0001348_abnormal_lacrimal_gland1.08665406
76MP0002405_respiratory_system_inflammati1.08569624
77MP0005084_abnormal_gallbladder_morpholo1.07932922
78MP0002733_abnormal_thermal_nociception1.06749475
79MP0002067_abnormal_sensory_capabilities1.05402532
80MP0003635_abnormal_synaptic_transmissio1.02449535
81MP0002282_abnormal_trachea_morphology1.01999567
82MP0001963_abnormal_hearing_physiology0.99306757
83MP0002752_abnormal_somatic_nervous0.99288263
84MP0003937_abnormal_limbs/digits/tail_de0.98838847
85MP0000955_abnormal_spinal_cord0.96425667
86MP0001346_abnormal_lacrimal_gland0.96246703
87MP0001293_anophthalmia0.96068471
88MP0005257_abnormal_intraocular_pressure0.95524661
89MP0004510_myositis0.94798735
90MP0002909_abnormal_adrenal_gland0.94351889
91MP0003646_muscle_fatigue0.93206588
92MP0004924_abnormal_behavior0.90723909
93MP0005386_behavior/neurological_phenoty0.90723909
94MP0002332_abnormal_exercise_endurance0.90692969
95MP0008961_abnormal_basal_metabolism0.89056917
96MP0009785_altered_susceptibility_to0.88721091
97MP0009780_abnormal_chondrocyte_physiolo0.87418321
98MP0004133_heterotaxia0.84457515
99MP0001502_abnormal_circadian_rhythm0.84422493
100MP0010094_abnormal_chromosome_stability0.83254655
101MP0003890_abnormal_embryonic-extraembry0.83157789
102MP0003718_maternal_effect0.81968671
103MP0003938_abnormal_ear_development0.81880544
104MP0003122_maternal_imprinting0.81003497
105MP0001765_abnormal_ion_homeostasis0.80491987
106MP0003119_abnormal_digestive_system0.79395528
107MP0004957_abnormal_blastocyst_morpholog0.78638802
108MP0004858_abnormal_nervous_system0.78611646
109MP0003436_decreased_susceptibility_to0.77984693
110MP0006035_abnormal_mitochondrial_morpho0.77920548
111MP0008058_abnormal_DNA_repair0.77730200
112MP0009115_abnormal_fat_cell0.77393481
113MP0002751_abnormal_autonomic_nervous0.77370009
114MP0002184_abnormal_innervation0.76583563
115MP0002882_abnormal_neuron_morphology0.75741159
116MP0005671_abnormal_response_to0.74363575
117MP0005025_abnormal_response_to0.74176780
118MP0005253_abnormal_eye_physiology0.73632862
119MP0005391_vision/eye_phenotype0.73203783
120MP0003786_premature_aging0.73151159
121MP0002092_abnormal_eye_morphology0.71275283
122MP0001849_ear_inflammation0.70571003
123MP0000358_abnormal_cell_content/0.69257579
124MP0005394_taste/olfaction_phenotype0.67765600
125MP0005499_abnormal_olfactory_system0.67765600
126MP0000313_abnormal_cell_death0.66986988
127MP0003448_altered_tumor_morphology0.65609712
128MP0001324_abnormal_eye_pigmentation0.64185307
129MP0005380_embryogenesis_phenotype0.64071367
130MP0001672_abnormal_embryogenesis/_devel0.64071367
131MP0002970_abnormal_white_adipose0.63541376
132MP0005397_hematopoietic_system_phenotyp0.62168449
133MP0001545_abnormal_hematopoietic_system0.62168449
134MP0003121_genomic_imprinting0.60011062
135MP0005000_abnormal_immune_tolerance0.59160671
136MP0003984_embryonic_growth_retardation0.57848030
137MP0002088_abnormal_embryonic_growth/wei0.56496737
138MP0002723_abnormal_immune_serum0.55319776
139MP0005389_reproductive_system_phenotype0.54862637
140MP0002928_abnormal_bile_duct0.54626375
141MP0008007_abnormal_cellular_replicative0.54385769
142MP0002277_abnormal_respiratory_mucosa0.53853404
143MP0003111_abnormal_nucleus_morphology0.51586012
144MP0003136_yellow_coat_color0.49363893
145MP0003077_abnormal_cell_cycle0.49153526
146MP0002420_abnormal_adaptive_immunity0.48519851
147MP0001819_abnormal_immune_cell0.48222784
148MP0000678_abnormal_parathyroid_gland0.46981981
149MP0008995_early_reproductive_senescence0.45791566
150MP0001800_abnormal_humoral_immune0.45528387
151MP0000689_abnormal_spleen_morphology0.45112792
152MP0002398_abnormal_bone_marrow0.44963758
153MP0004019_abnormal_vitamin_homeostasis0.44022383
154MP0005647_abnormal_sex_gland0.44006600
155MP0005387_immune_system_phenotype0.43731196
156MP0001790_abnormal_immune_system0.43731196
157MP0005266_abnormal_metabolism0.43102895
158MP0002452_abnormal_antigen_presenting0.42910899
159MP0002148_abnormal_hypersensitivity_rea0.42733952
160MP0002419_abnormal_innate_immunity0.42398353
161MP0000716_abnormal_immune_system0.42224696
162MP0002269_muscular_atrophy0.41996096
163MP0001984_abnormal_olfaction0.41682302
164MP0006036_abnormal_mitochondrial_physio0.41680984
165MP0003186_abnormal_redox_activity0.41266901
166MP0002429_abnormal_blood_cell0.40635025
167MP0005636_abnormal_mineral_homeostasis0.40576357
168MP0001270_distended_abdomen0.40449671
169MP0000049_abnormal_middle_ear0.40227893
170MP0000858_altered_metastatic_potential0.39993410
171MP0002932_abnormal_joint_morphology0.39060300
172MP0004381_abnormal_hair_follicle0.37922358
173MP0002127_abnormal_cardiovascular_syste0.37416079

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39374610
2Abnormal respiratory epithelium morphology (HP:0012253)8.70882805
3Abnormal respiratory motile cilium morphology (HP:0005938)8.70882805
4Rhinitis (HP:0012384)8.18612686
5Abnormal ciliary motility (HP:0012262)7.84440764
6Nasal polyposis (HP:0100582)7.19618404
7Chronic bronchitis (HP:0004469)7.11900747
8Abnormality of the nasal mucosa (HP:0000433)5.90954610
9Infertility (HP:0000789)5.69620892
10Bronchitis (HP:0012387)4.89365085
11Bronchiectasis (HP:0002110)4.78532618
12Pancreatic cysts (HP:0001737)4.47279300
13Hypoplasia of the pons (HP:0012110)4.02878968
14Abnormality of the pons (HP:0007361)3.79081678
15Recurrent sinusitis (HP:0011108)3.60019578
16Nephronophthisis (HP:0000090)3.47184597
17Male infertility (HP:0003251)3.46567779
18Recurrent bronchitis (HP:0002837)3.41007976
19Recurrent otitis media (HP:0000403)3.20473825
20Congenital, generalized hypertrichosis (HP:0004540)3.14563947
21Impulsivity (HP:0100710)3.07444583
22Occipital encephalocele (HP:0002085)2.91699137
23Sclerocornea (HP:0000647)2.90402991
24Chronic hepatic failure (HP:0100626)2.88934359
25Type II lissencephaly (HP:0007260)2.88175768
26Male pseudohermaphroditism (HP:0000037)2.80712917
27Tubulointerstitial nephritis (HP:0001970)2.79286926
28Bilateral microphthalmos (HP:0007633)2.79038919
29Molar tooth sign on MRI (HP:0002419)2.69381064
30Abnormality of midbrain morphology (HP:0002418)2.69381064
31Abnormality of the renal cortex (HP:0011035)2.64174454
32Gait imbalance (HP:0002141)2.58175195
33Abnormality of the renal medulla (HP:0100957)2.53673119
34Congenital stationary night blindness (HP:0007642)2.53405890
35Congenital primary aphakia (HP:0007707)2.52381199
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.48573589
37Abnormal spermatogenesis (HP:0008669)2.45431742
38Furrowed tongue (HP:0000221)2.42570625
39Abnormal number of erythroid precursors (HP:0012131)2.31328742
40Bile duct proliferation (HP:0001408)2.31131934
41Abnormal biliary tract physiology (HP:0012439)2.31131934
42Abnormality of the lower motor neuron (HP:0002366)2.30752057
43Nephrogenic diabetes insipidus (HP:0009806)2.24928123
44Amyotrophic lateral sclerosis (HP:0007354)2.23984963
45Dyschromatopsia (HP:0007641)2.19061741
46Cerebellar dysplasia (HP:0007033)2.18970711
47Abnormal rod and cone electroretinograms (HP:0008323)2.11002163
48Abnormal drinking behavior (HP:0030082)2.10880027
49Polydipsia (HP:0001959)2.10880027
50Septo-optic dysplasia (HP:0100842)2.09922840
51Acute necrotizing encephalopathy (HP:0006965)2.08351664
52Spastic tetraparesis (HP:0001285)2.05942653
53Abnormality of cells of the erythroid lineage (HP:0012130)2.01609838
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7113759
55Dynein arm defect of respiratory motile cilia (HP:0012255)11.0290884
56Absent/shortened dynein arms (HP:0200106)11.0290884
57Tubulointerstitial abnormality (HP:0001969)1.99352779
58Large for gestational age (HP:0001520)1.99044811
59Vaginal atresia (HP:0000148)1.98585891
60Postaxial foot polydactyly (HP:0001830)1.97842305
61Genital tract atresia (HP:0001827)1.97387162
62Mitochondrial inheritance (HP:0001427)1.95776978
63Concave nail (HP:0001598)1.95536776
64Supernumerary spleens (HP:0009799)1.92508674
65Decreased circulating renin level (HP:0003351)1.90422482
66Medial flaring of the eyebrow (HP:0010747)1.89197363
67Attenuation of retinal blood vessels (HP:0007843)1.88992615
68Facial cleft (HP:0002006)1.88528974
69Preaxial hand polydactyly (HP:0001177)1.86406599
70Nephroblastoma (Wilms tumor) (HP:0002667)1.84918784
71Bifid tongue (HP:0010297)1.84756089
72Retinal dysplasia (HP:0007973)1.81379418
73Hemiparesis (HP:0001269)1.80719389
74Renal cortical cysts (HP:0000803)1.80663604
75Tubular atrophy (HP:0000092)1.80531841
76Congenital hepatic fibrosis (HP:0002612)1.80121196
77Abnormal gallbladder physiology (HP:0012438)1.80020706
78Cholecystitis (HP:0001082)1.80020706
79Abolished electroretinogram (ERG) (HP:0000550)1.79276060
80Chronic sinusitis (HP:0011109)1.78216816
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77615822
82Acute encephalopathy (HP:0006846)1.76794057
83Abnormal mitochondria in muscle tissue (HP:0008316)1.75931402
84Abnormality of the labia minora (HP:0012880)1.75170694
85Progressive macrocephaly (HP:0004481)1.74861211
86Gonadotropin excess (HP:0000837)1.72807408
87Abnormality of the dental root (HP:0006486)1.72264297
88Taurodontia (HP:0000679)1.72264297
89Abnormality of permanent molar morphology (HP:0011071)1.72264297
90Abnormality of dentin (HP:0010299)1.72183977
91Anophthalmia (HP:0000528)1.71450561
92Absent septum pellucidum (HP:0001331)1.70071120
93Poor coordination (HP:0002370)1.69805686
94Optic nerve hypoplasia (HP:0000609)1.68826783
95Optic disc pallor (HP:0000543)1.68362978
96Embryonal renal neoplasm (HP:0011794)1.67860145
97Maternal diabetes (HP:0009800)1.65305401
98Lissencephaly (HP:0001339)1.64716504
99Polyuria (HP:0000103)1.63193425
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62241011
101Abnormality of alanine metabolism (HP:0010916)1.62241011
102Hyperalaninemia (HP:0003348)1.62241011
103Constricted visual fields (HP:0001133)1.61425336
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60561151
105Multiple enchondromatosis (HP:0005701)1.59889469
106Increased CSF lactate (HP:0002490)1.58130374
107Polyphagia (HP:0002591)1.57597219
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.56216736
109Abnormality of the dental pulp (HP:0006479)1.55949160
110Absent frontal sinuses (HP:0002688)1.55787857
1113-Methylglutaconic aciduria (HP:0003535)1.55753485
112Abnormality of the phalanges of the hallux (HP:0010057)1.55095035
113Hyperventilation (HP:0002883)1.55067640
114Specific learning disability (HP:0001328)1.54964964
115Retinitis pigmentosa (HP:0000510)1.54646413
116Focal motor seizures (HP:0011153)1.54159186
117Chronic otitis media (HP:0000389)1.54098732
118Oculomotor apraxia (HP:0000657)1.53508422
119Abnormality of molar morphology (HP:0011070)1.52143098
120Abnormality of molar (HP:0011077)1.52143098
121Abnormal lung lobation (HP:0002101)1.51884106
122Cleft eyelid (HP:0000625)1.51071782
123Postaxial hand polydactyly (HP:0001162)1.49565919
124Short humerus (HP:0005792)1.49280432
125Orchitis (HP:0100796)1.49018335
126Heterotopia (HP:0002282)1.47586542
127Sensory axonal neuropathy (HP:0003390)1.46591194
128Median cleft lip (HP:0000161)1.39533573
129Aplasia/hypoplasia of the humerus (HP:0006507)1.39143531
130Neoplasm of the heart (HP:0100544)1.37867402
131Azoospermia (HP:0000027)1.36870058
132Tubulointerstitial fibrosis (HP:0005576)1.36593232
133Pendular nystagmus (HP:0012043)1.34294883
134Impaired proprioception (HP:0010831)1.33800971
135Pancreatic fibrosis (HP:0100732)1.32753125
136Decreased central vision (HP:0007663)1.32670073
137Short thorax (HP:0010306)1.32496751
138Myositis (HP:0100614)1.31916082
139Hemorrhage of the eye (HP:0011885)1.31814596
140Upper motor neuron abnormality (HP:0002127)1.30845370
141Short ribs (HP:0000773)1.30657808
142Hand muscle atrophy (HP:0009130)1.29821962
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.29021299
144Stage 5 chronic kidney disease (HP:0003774)1.29004670
145Hypochromic microcytic anemia (HP:0004840)1.28702807
146Anencephaly (HP:0002323)1.26182137
147Villous atrophy (HP:0011473)1.25630734
148Abnormality of small intestinal villus morphology (HP:0011472)1.25630734
149Rib fusion (HP:0000902)1.25410829
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.25082031
151Choroideremia (HP:0001139)1.24791122
152Neoplasm of striated muscle (HP:0009728)1.24660224
153True hermaphroditism (HP:0010459)1.24645919
154Hepatoblastoma (HP:0002884)1.23597568
155Abnormality of renal excretion (HP:0011036)1.23375773
156Sloping forehead (HP:0000340)1.22803907
157Aplasia/Hypoplasia of the lens (HP:0008063)1.21847978
158Truncal obesity (HP:0001956)1.21449459
159Cystic liver disease (HP:0006706)1.19638397
160Ependymoma (HP:0002888)1.17983689
161Aplasia/Hypoplasia affecting the retina (HP:0008061)1.17065939
162Broad distal phalanx of finger (HP:0009836)1.16782951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.41260822
2PDK36.17882058
3PDK46.17882058
4INSRR4.34755466
5PRKD34.25545343
6ICK4.03451524
7PDK24.02850828
8CDK123.44596006
9FRK3.02030831
10WNK32.82139478
11GRK52.46284252
12TLK12.39249284
13MAP4K22.20072646
14DAPK22.18918243
15GRK62.18399284
16ERN12.09263768
17PINK12.00618393
18BMPR1B1.91128092
19DYRK1B1.91032464
20GRK11.82008396
21MAP3K41.81567616
22ADRBK21.77047215
23NME11.75788118
24CSF1R1.70637087
25TYRO31.64791899
26PTK2B1.61365151
27STK101.58654028
28WNK41.55477392
29MAPK151.53732321
30TTK1.52075658
31NEK21.48429922
32CASK1.47343787
33MAPK131.45810757
34VRK11.43943205
35ZAK1.43506247
36WNK11.42412653
37STK381.41783102
38CAMKK21.40832003
39VRK21.36915087
40PNCK1.33493737
41NUAK11.29983500
42DYRK21.29852844
43EPHB21.25302926
44STK391.21641118
45STK38L1.20182729
46MAP2K71.15663400
47BCR1.15071957
48MARK11.14641041
49MAP2K61.13088129
50PAK31.11637862
51MUSK1.11369709
52PDK11.10702747
53STK161.08228055
54MATK1.07558272
55DYRK31.05734341
56TGFBR11.05127093
57BCKDK1.01277110
58RIPK41.00410477
59GRK70.99722668
60PLK40.96060900
61MKNK20.95545119
62TESK20.94568301
63TGFBR20.92691841
64OXSR10.92276241
65PRKG20.91528082
66CHEK20.89117615
67PAK40.86931723
68MKNK10.83020996
69PKN10.81350251
70PRKCE0.80510508
71MOS0.77232633
72PASK0.76692360
73CCNB10.76087940
74FGFR20.75704388
75TNIK0.72594364
76NTRK30.69880862
77EPHA40.69575060
78MAPK70.69397113
79TAOK30.67190128
80PLK30.65325562
81STK240.64919734
82STK30.63594969
83TIE10.61913860
84ITK0.60480070
85MAP2K40.60067295
86MARK20.60029616
87PRKACA0.57784289
88ACVR1B0.57155616
89WEE10.57062220
90MAP3K120.56810998
91KIT0.56595013
92PDPK10.56300454
93PLK10.56213381
94CAMK2A0.54697381
95TRIM280.54123983
96CSK0.53852755
97RPS6KA50.52188622
98CAMKK10.51961364
99MAP3K100.51642605
100PAK10.51506728
101CHEK10.51161090
102CAMK10.50949535
103PRKG10.50205749
104IRAK10.49332335
105MINK10.48716897
106MAPKAPK30.48441790
107PHKG10.48317658
108PHKG20.48317658
109NTRK20.48302688
110ZAP700.48059307
111CSNK1A10.47929823
112ERBB20.45200614
113PLK20.44144320
114PRKCI0.43741348
115PIK3CA0.43338029
116UHMK10.42706924
117CSNK1G20.42256965
118IRAK20.40475276
119TAF10.40458203
120CDK70.37903665
121EEF2K0.37638416
122PRKACB0.37050864
123PAK60.36729592
124MST40.35742553
125PRKCD0.35356301
126ADRBK10.34564285
127PRKCA0.33267257
128RPS6KA60.33075079
129EPHA30.32550983
130CSNK1G10.31822238
131MAPKAPK50.31122434
132EPHA20.30541515
133MAP4K10.30126047
134ATM0.29980639
135STK110.29483951
136CSNK1G30.29431425
137ERBB30.29372647
138CAMK2B0.28716362
139IRAK40.27191233
140PAK20.26820257
141PRKCQ0.26408764
142PIM10.25864848
143AURKA0.24211774
144CAMK40.24045533
145BTK0.23698579
146MTOR0.22738990
147NEK90.22574371
148NTRK10.22546351
149BUB10.22055483
150ATR0.20819433
151IGF1R0.19920619
152SYK0.19496098
153PIM20.19038771
154CLK10.18992460
155PRKCG0.18726433
156BRSK10.16294311
157BRSK20.15686814
158HIPK20.14823370
159LMTK20.12854533
160TRIB30.12814415
161AURKB0.11798654
162CDK20.11187771
163CSNK2A10.11136835
164TEC0.09999940
165PRKAA10.09722191
166PRKACG0.09153966
167MAP3K50.08482196
168RPS6KA10.08412987
169MAPK40.08187514
170TAOK10.08086764
171FGFR30.07954175
172LCK0.07820519
173IKBKB0.07802924
174YES10.07513600
175CDK40.07188903
176CDK150.07150921

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.10525476
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.96335492
3Linoleic acid metabolism_Homo sapiens_hsa005913.49274286
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.45953883
5Oxidative phosphorylation_Homo sapiens_hsa001903.10095239
6Fructose and mannose metabolism_Homo sapiens_hsa000513.08925520
7Fatty acid biosynthesis_Homo sapiens_hsa000613.01831679
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68758684
9Parkinsons disease_Homo sapiens_hsa050122.56829379
10Ribosome_Homo sapiens_hsa030102.51606311
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49788477
12Caffeine metabolism_Homo sapiens_hsa002322.48587619
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.40664211
14Phototransduction_Homo sapiens_hsa047442.37534291
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.36132396
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27683910
17Arachidonic acid metabolism_Homo sapiens_hsa005902.27215737
18Nicotine addiction_Homo sapiens_hsa050332.17884312
19Basal transcription factors_Homo sapiens_hsa030222.04877902
20Antigen processing and presentation_Homo sapiens_hsa046122.00413122
21Butanoate metabolism_Homo sapiens_hsa006502.00187799
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00186960
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.98100868
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97588219
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85555938
26Ether lipid metabolism_Homo sapiens_hsa005651.84935849
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78508029
28Alzheimers disease_Homo sapiens_hsa050101.77268727
29Protein export_Homo sapiens_hsa030601.71449414
30Other glycan degradation_Homo sapiens_hsa005111.69808660
31Fanconi anemia pathway_Homo sapiens_hsa034601.67877099
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65879732
33Selenocompound metabolism_Homo sapiens_hsa004501.65659890
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64615841
35Pyruvate metabolism_Homo sapiens_hsa006201.63220179
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62115277
37Nitrogen metabolism_Homo sapiens_hsa009101.60572779
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60015730
39Histidine metabolism_Homo sapiens_hsa003401.56546355
40Basal cell carcinoma_Homo sapiens_hsa052171.55005004
41Glucagon signaling pathway_Homo sapiens_hsa049221.51201941
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.49531235
43Pentose phosphate pathway_Homo sapiens_hsa000301.49529043
44Glycerolipid metabolism_Homo sapiens_hsa005611.47119990
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46022761
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43577282
47PPAR signaling pathway_Homo sapiens_hsa033201.43484828
48Tryptophan metabolism_Homo sapiens_hsa003801.40809568
49Taste transduction_Homo sapiens_hsa047421.40785657
50Galactose metabolism_Homo sapiens_hsa000521.40368812
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38988658
52Steroid biosynthesis_Homo sapiens_hsa001001.38470556
53beta-Alanine metabolism_Homo sapiens_hsa004101.33965208
54DNA replication_Homo sapiens_hsa030301.27270891
55Peroxisome_Homo sapiens_hsa041461.24605773
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24131896
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.22840014
58RNA polymerase_Homo sapiens_hsa030201.21917755
59Legionellosis_Homo sapiens_hsa051341.21530263
60Mineral absorption_Homo sapiens_hsa049781.15120751
61Tyrosine metabolism_Homo sapiens_hsa003501.13279174
62Olfactory transduction_Homo sapiens_hsa047401.12808874
63Sulfur relay system_Homo sapiens_hsa041221.10886352
64Phenylalanine metabolism_Homo sapiens_hsa003601.06876969
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06578946
66Chemical carcinogenesis_Homo sapiens_hsa052041.05675190
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01799349
68Primary bile acid biosynthesis_Homo sapiens_hsa001201.00249863
69mRNA surveillance pathway_Homo sapiens_hsa030150.99636681
70RNA transport_Homo sapiens_hsa030130.99486611
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99229703
72Huntingtons disease_Homo sapiens_hsa050160.98902000
73Purine metabolism_Homo sapiens_hsa002300.95570858
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95223608
75Morphine addiction_Homo sapiens_hsa050320.93646093
76Glutathione metabolism_Homo sapiens_hsa004800.92078479
77Propanoate metabolism_Homo sapiens_hsa006400.90604262
78Insulin secretion_Homo sapiens_hsa049110.90376034
79Pyrimidine metabolism_Homo sapiens_hsa002400.89255762
80Dorso-ventral axis formation_Homo sapiens_hsa043200.88800549
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88766102
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.84450931
83Serotonergic synapse_Homo sapiens_hsa047260.83933118
84Oocyte meiosis_Homo sapiens_hsa041140.82478942
85Carbon metabolism_Homo sapiens_hsa012000.81656919
86Proteasome_Homo sapiens_hsa030500.79453897
87Glutamatergic synapse_Homo sapiens_hsa047240.78778507
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77523720
89Hedgehog signaling pathway_Homo sapiens_hsa043400.75958661
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74506868
91Circadian entrainment_Homo sapiens_hsa047130.74075652
92GABAergic synapse_Homo sapiens_hsa047270.73462588
93Inositol phosphate metabolism_Homo sapiens_hsa005620.72925791
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71890084
95Base excision repair_Homo sapiens_hsa034100.70597132
96Cocaine addiction_Homo sapiens_hsa050300.70497242
97B cell receptor signaling pathway_Homo sapiens_hsa046620.69826799
98Fat digestion and absorption_Homo sapiens_hsa049750.69219310
99Ovarian steroidogenesis_Homo sapiens_hsa049130.67088013
100Regulation of autophagy_Homo sapiens_hsa041400.66514626
101Homologous recombination_Homo sapiens_hsa034400.65720070
102Cardiac muscle contraction_Homo sapiens_hsa042600.64644553
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.64329471
104Salivary secretion_Homo sapiens_hsa049700.64218006
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63687377
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62472333
107Renin-angiotensin system_Homo sapiens_hsa046140.61579597
108Collecting duct acid secretion_Homo sapiens_hsa049660.59861819
109Folate biosynthesis_Homo sapiens_hsa007900.59278986
110Hippo signaling pathway_Homo sapiens_hsa043900.58047298
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56324826
112Calcium signaling pathway_Homo sapiens_hsa040200.55429230
113Measles_Homo sapiens_hsa051620.54487768
114Primary immunodeficiency_Homo sapiens_hsa053400.53891101
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53409258
116Amphetamine addiction_Homo sapiens_hsa050310.52651881
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50114373
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48386346
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48268840
120RNA degradation_Homo sapiens_hsa030180.47778028
121Influenza A_Homo sapiens_hsa051640.47597254
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46130627
123Dopaminergic synapse_Homo sapiens_hsa047280.45482646
124One carbon pool by folate_Homo sapiens_hsa006700.45295939
125Circadian rhythm_Homo sapiens_hsa047100.45270267
126Fatty acid degradation_Homo sapiens_hsa000710.44706383
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41361050
128Leishmaniasis_Homo sapiens_hsa051400.40190284
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39495668
130Metabolic pathways_Homo sapiens_hsa011000.39363238
131Arginine and proline metabolism_Homo sapiens_hsa003300.38244653
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.37789191
133Herpes simplex infection_Homo sapiens_hsa051680.37672023
134Mismatch repair_Homo sapiens_hsa034300.37391652
135Toxoplasmosis_Homo sapiens_hsa051450.37175951
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36427286
137AMPK signaling pathway_Homo sapiens_hsa041520.35758266
138ABC transporters_Homo sapiens_hsa020100.35023486
139cAMP signaling pathway_Homo sapiens_hsa040240.34987955
140Malaria_Homo sapiens_hsa051440.34552201
141Melanogenesis_Homo sapiens_hsa049160.34033666
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33963653
143VEGF signaling pathway_Homo sapiens_hsa043700.33805953
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33644158
145Endocytosis_Homo sapiens_hsa041440.33444698
146Salmonella infection_Homo sapiens_hsa051320.32724179
147Retinol metabolism_Homo sapiens_hsa008300.32148440
148Fatty acid metabolism_Homo sapiens_hsa012120.31964433
149Systemic lupus erythematosus_Homo sapiens_hsa053220.30759551
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30538064
151Bile secretion_Homo sapiens_hsa049760.30216832
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29631024
153Cell cycle_Homo sapiens_hsa041100.28350497
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28204520
155Nucleotide excision repair_Homo sapiens_hsa034200.27896275
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27862148
157African trypanosomiasis_Homo sapiens_hsa051430.26137579
158T cell receptor signaling pathway_Homo sapiens_hsa046600.25979960
159RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24603747
160Renin secretion_Homo sapiens_hsa049240.24530520
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.23570086
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23494499
163Lysosome_Homo sapiens_hsa041420.23241667
164Biosynthesis of amino acids_Homo sapiens_hsa012300.21385239
165Osteoclast differentiation_Homo sapiens_hsa043800.19606439
166Viral carcinogenesis_Homo sapiens_hsa052030.18671016

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